LOCUS       NZ_CP022098            10831 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 11205424
            Orig. end                         :: 11216255
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="55"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5831](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    164..176
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     misc_feature    complement(1012..1030)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    1449..1465
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.74"
                     /tool="antismash"
     gene            complement(1502..2467)
                     /locus_tag="CYFUS_RS45360"
                     /old_locus_tag="CYFUS_008967"
     CDS             complement(1502..2467)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025388.4"
                     /locus_tag="CYFUS_RS45360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008967"
                     /product="DUF4238 domain-containing protein"
                     /protein_id="WP_157759030.1"
                     /transl_table=11
                     /translation="MKCHFVPQGYLRRFTNEKNLLECCDLHRDYQLTRTQSTKATAQIE
                     DWYVLRKPQDTPVLEYVGEKDIEEAFVSLYEKDLPAALDRLERQSITFSDKELLARFVA
                     IQLHRAPISREYYRQVKRQDAKQVLSHEKTLQRNAGIARGFLGTLVSGITLEPFLMEST
                     WVLVRRTGTTPFITSDNPIHAHNHPQNQNHLAQVQDFMAARGQSFSDAELKARKGGYGV
                     SVSPQHVLYINTSLPRNPADIWVETGSWDEARVQQYNDLVFRSCLSCVYTVTKELALSY
                     AQRHTRGEIQNDLFVDDPFQETIQSPNTSGQESQGPEPST"
     misc_feature    complement(2484..2497)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.5"
                     /tool="antismash"
     misc_feature    2674..2687
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.05"
                     /tool="antismash"
     misc_feature    3242..3251
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            3787..4194
                     /locus_tag="CYFUS_RS45370"
                     /old_locus_tag="CYFUS_008968"
     CDS             3787..4194
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017559.4"
                     /locus_tag="CYFUS_RS45370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008968"
                     /product="FixH family protein"
                     /protein_id="WP_157759031.1"
                     /transl_table=11
                     /translation="MRLPARLAHVLLSVLLACACSPGSEPGTAPDAGGDTASGLVRLEA
                     GFEGTLQPRGNRLRIHVTDTAGTPVEATRVSVSLWMPGHGHGAPAPAVTREARGDYLAT
                     VDFTMPGTWTVTIQVDTEGRSDTLELSVEAP"
     misc_feature    4174..4176
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4233..4246)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            4276..5004
                     /locus_tag="CYFUS_RS45375"
                     /old_locus_tag="CYFUS_008969"
     CDS             4276..5004
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024834.4"
                     /locus_tag="CYFUS_RS45375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008969"
                     /product="cytochrome c"
                     /protein_id="WP_095990895.1"
                     /transl_table=11
                     /translation="MTPNDTSSAPNASPGQPSRKLLLAAVAGLMGLGSAGCGQPDEPPP
                     SQGVPDPEPQGPHVVSRSTVEGGLTFERFSADCEQRGGFVQTHAVCSGNNSCKGVSYNR
                     FDYSLTEHTCKALNSCGGMSCIELPADSGKTGEEVYKNSCGPVCHSHTNTTAFVYYVAP
                     GTAPDTARQQFLSRSRLYQQSIVAFGIHGMSADGVLSANMPAFHAKYSRKEIERVVDYV
                     RQLELEVEAYEVMGPAAPVP"
     gene            5001..5831
                     /locus_tag="CYFUS_RS45380"
                     /old_locus_tag="CYFUS_008970"
     CDS             5001..5831
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626551.1"
                     /locus_tag="CYFUS_RS45380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008970"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_095990896.1"
                     /sec_met_domain="DUF692 (E-value: 2.7e-85, bitscore: 285.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPVPTPRADALGLGLRLPHLEALKQAWPESVAYVEIISENYLG
                     AAAPPRRHLAWVRERVPVVLHGVGLNLLGHEPLDEAYLDEVCRLADAMDAPFVSDHLCW
                     VRAGGLSHHDLLPTPFRADLIDFAAERAAWVQRRLGRPFGLENLSSYVSFPESDLTEWE
                     FYASVVREAGCYFMLDLNNIYVSGRNHGFDPRGYLDAIDFGRVLQVHLAGHEPEPDGTL
                     VDTHGQPVDGAVWELYAQAWRRGGPFPTLLEWDTNVPPLARAVEELERAAGVRA"
     gene            5828..6640
                     /locus_tag="CYFUS_RS45385"
                     /old_locus_tag="CYFUS_008971"
     CDS             5828..6640
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="CYFUS_RS45385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008971"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_157759032.1"
                     /transl_table=11
                     /translation="MSPSRAPPEWLAGFQERFGATLRTPLDASSGTLRPVEQGTGRGLY
                     NRQYWFRLFEVLQGEYPLTARLLGLFPFNLLVQRFAREHPPREWDLRLAGRGFGSWLRT
                     QVSSLPAGLPAAALAEATDIDTAWSEVWMAPEVPAWAPSPEELATLEERFLRASPACRL
                     LEESWPLVALRRTLGPDADARRQPLPPPLPTRQHWMLLRHGEALIQVPLSPVRARLLWA
                     LRTKTFGAALAEVEASLPLSEQEALVAHIGTWLAEGLRWGFWVGTADR"
     gene            6703..6882
                     /locus_tag="CYFUS_RS45390"
                     /old_locus_tag="CYFUS_008972"
     CDS             6703..6882
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS45390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_008972"
                     /product="hypothetical protein"
                     /protein_id="WP_095990898.1"
                     /transl_table=11
                     /translation="MLSTTALHWLPAERLVALYHQPGRLVRPGGMFLNGDNIPFSHRPS
                     PFQRLAEQARRAAV"
     gene            6975..7808
                     /locus_tag="CYFUS_RS45395"
                     /old_locus_tag="CYFUS_008973"
     CDS             6975..7808
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS45395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_008973"
                     /product="hypothetical protein"
                     /protein_id="WP_157759033.1"
                     /transl_table=11
                     /translation="MNVLARIGLLVWLSWGIGGCLLSDDVCTPADTTYSCCVKQHLGDA
                     SQCNALEAEVRVLEPTVHPSTPRTHGTAVAVGTVVAAATLSSDGEIFSEKLRAAVEKIL
                     QECAIQAHETVNRRRIGGDPTREQCEEILKWDPSGQPITRAMKLGEEKHAEAIECARNR
                     LSQLLPGRFSLEQRYRHTPTTGQLELVSPKQHQESMRKNQGRDMKGTLVPDIVIHAQGN
                     PLKTQFVYDFKFPCLFSNRPKWTVYKEGPYRDQTQGTVYEKVFGPALRVTPWEIN"
     misc_feature    7779..7781
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7808..8692
                     /locus_tag="CYFUS_RS45400"
                     /old_locus_tag="CYFUS_008974"
     CDS             7808..8692
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023304.4"
                     /locus_tag="CYFUS_RS45400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008974"
                     /product="type VI immunity family protein"
                     /protein_id="WP_232537182.1"
                     /transl_table=11
                     /translation="MNGRYPHFKGHTPAGLHILRDGLVMNFFIQRPHRQIGGSIVRALA
                     VYRQHVGLEKLGFYTGYEGYDLRLDAKALSDIHEQLINADGCVIQLWEHDDQWSGYRFD
                     YRGRMLGTDTYIRSPDAVSCASFWLPTEYLEEQGPARVKELAMALARELPLTSGYANLA
                     FNGMMDTFRVGPLIHDLCFRYPGLDIVDDNVTYDLGTRPKGAYWLNFYGQPLLDKLGGV
                     AGLRERLTLPGISVEQLQPDKVLVQLGEWPEADGELRPYRQLARVLEPHLYQEARPVLP
                     AEVMRRWERRFLD"
     gene            complement(8696..9607)
                     /locus_tag="CYFUS_RS45405"
                     /old_locus_tag="CYFUS_008975"
     CDS             complement(8696..9607)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS45405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_008975"
                     /product="hypothetical protein"
                     /protein_id="WP_095990901.1"
                     /transl_table=11
                     /translation="MNGRVWGAVAVGVLLALPLVGLLWTSVSPQRAGTWRRLPMISPDE
                     RLARPSFLEACASSAECDPPLACFSDRRYDRQTCNGSDCLIDADCALGSVCRWNPVGDG
                     TKTAIASCTFVGVREEGESCLRLPRRDEGACERGLVCADWCARRCGLWPFNSCPEGYFC
                     AEDDPNGPVCLPTCEGRVCPEGEQCVREATPGVSVCARVHGPNCQREPCAEGLTCKVDT
                     SPVRPGEAWMECVTPCTGEGSFASPCPGFSACLFGTCHDICSLGEEDPCAPDYICVPMH
                     GDSGVCAWAPQLPEPVDAPRGK"
     gene            complement(9624..10601)
                     /locus_tag="CYFUS_RS45410"
                     /old_locus_tag="CYFUS_008976"
     CDS             complement(9624..10601)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011556405.1"
                     /locus_tag="CYFUS_RS45410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_008976"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_095990902.1"
                     /transl_table=11
                     /translation="MSLLEVKGLRRDFGALRAVDDVSFELEAGTVLGFIGPNGAGKSTT
                     MRILATLDTPTAGEVLLDGYSLVDTPDKVRPLIGYMPDRYGTYEDVTVFEFLDFFARAY
                     GLTGPVRARRLASVMEFTGLGPLADKLTHSLSKGMKQRVALGRTLLHDPKLLILDEPAD
                     GLDPRARIELRELLRALADQGKAVLISSHILTELAEICDTCAIIEQGRLLATGKVADVL
                     AQAAGTAVVELLVRLFPGAEGEAEWARAERLLWEQPHVKEIAREGQALRVRLEQEGAAA
                     EWGDEVAARLLRVLVEAGVPVCAFGHRERNLEDAFMRVTRGRVA"
ORIGIN
        1 aactcaccga tggtgcacat tgcacctgga atagtctcaa tgacttcttt caatgctttc
       61 cagccactgt ctgagagatt tctgatttta tcgtcaggct caaggcactc cgcgattaga
      121 acccgaagct gcttctttag aaacacaaat ggaaattgac tcatttccat ttgcaacgtg
      181 cgcgtcaggg gaagcacagg cctgatagat acaggtgaca cacacagaag tggcgaggag
      241 tgctctggga gcctcatgag ccctaccgga aaattcgtaa aggcgtgcac gcgatttgcc
      301 ctgtacatca ccttgaggct ctcttcgcca atgactttct gtagatgacg cgaaatacga
      361 tccagttgac gccaaacctc tttcgagttg attctggggg aggctatgac aagcttttcg
      421 atgctggcca gggcttgaaa tgcttcatca ggaacatcct ccgccatgat acccaatcca
      481 ctcgtcgcca cagctcggtg cgcaacgcac tgctggatga ttcttctttc cagctcaaga
      541 ttggcactcg acggcttgaa tttctttcca tacgccattt gttgatactt gcgcggaact
      601 ccgggtagac caatggcgac tggcaattga atttctgcct ttatttcgct gatgatcttc
      661 tcatacacct ctcgcgtggc ctcttctttc gagagcttgc ggcgctccat ctctgcaatc
      721 gcgtagatca tgcttcgcac atgcaaccgg aaaagctggg cgttgcgcgt gtcgccaagc
      781 tcagagaaag gaatgccgtc agttcgtctt agttggtgtg catcgagaat tgatgggaga
      841 acgttatggc ctgcaagttc tttcgggagt ttagggggcg ggacctcaat ccgaccgtaa
      901 gaggagccat caatcgctgt taaggctaag ggtagttgag tgagcacttt ccaatgatgg
      961 gcgcgcagtt catcgttcaa cttatcgaag acagccaccc ctaatggagg catggttttt
     1021 tcagccagta tttgcgcccg tgattcagac tctggtgagc atatgattaa tgtgggatga
     1081 cgcgccgcga ggccattaag cagcatctcg ttgtctagaa gagataccgg agcgatcatt
     1141 atattgtgcg agagatccag atttcggaac ttgtacaaca acgtggcact ccaatcgatg
     1201 gtgtcgccca gcgaacgggg caattggagg cagtagtcaa tcgcgggaag aataggctct
     1261 agagccaaat cgaagccgtg aggaagcgtt gtgttgccag aaacggcctc ctctgaactc
     1321 acgacgggga cttgttcgtg tgttccagac gggtcatcga atagaatgag atataagaga
     1381 tctagtgggt ccagcttcgc tggtgcaagc atagtagagt cctcaacgct gactgccaag
     1441 gtgcaacaga gtagtttact tacataagcg gttcagctcc gcttgttgct tagtcgtgaa
     1501 ctcatgtact cggctctggt ccttggctct cctgtcctga cgtattaggg ctttggatag
     1561 tctcctggaa ggggtcgtcg acgaagagat cgttctgaat ttcgccgcgc gtgtgccttt
     1621 gagcgtagct caacgcaagt tccttcgtta cagtgtagac gcaactcagg catgacctga
     1681 aaacgaggtc gttgtactgc tgcaccctgg cctcgtccca actaccagtc tccacccaga
     1741 tgtctgctgg atttctaggc aggcttgtgt tgatgtaaag cacatgctga ggagagacgc
     1801 ttacgccata cccgcctttt cgagccttga gttctgcatc actgaaagat tggccgcgcg
     1861 cggccatgaa gtcctgcacc tgcgcaaggt ggttctggtt ctgcgggtgg ttgtgagcgt
     1921 gaatggggtt gtcgctcgta atgaatggcg tggtccctgt cctcctgaca agcacccaag
     1981 tagactccat tagaaatggc tcaagagtta tcccgctcac gagcgttccc aggaagccgc
     2041 gcgcaattcc tgcattgcgc tgcaaggttt tctcatgaga aagcacctgc ttggcatcct
     2101 gacgtttcac ctgccggtaa tactccctgg agatgggggc tcggtgcagt tgaatagcca
     2161 caaatcttgc caggagttcc ttgtctgaga aggtgatact ctggcgctcc aagcgatcca
     2221 gagccgcagg caagtccttc tcgtaaagag acacgaaagc ctcttcaatg tccttctctc
     2281 ctacatactc aaggacaggc gtgtcctgtg gcttgcgcag cacgtaccag tcttcgattt
     2341 gcgccgtcgc cttcgtcgat tgagtcctgg tgagctgata atcccggtgg aggtcgcagc
     2401 actcaagaag gttcttctcg ttggtgaacc ggcgcaaata tccctgtggg acgaagtggc
     2461 atttcatggc tgaaaagcct ccctgcaaga tcttgcagca caagacaagc tcggccagaa
     2521 agcagaggag cacccttgcc ctcttttggg tgctgatgaa atggtacgaa cgttgccgct
     2581 catctcaacc agtttcgggt tcatgcgtgt agcgtggtgc tccttacgct gaagtcggct
     2641 actaccgatg aatgatgtgc tactgcggct cccattttca cccaaaaggc aagctgacct
     2701 aagcgctcgc gcccggccgc atttctccac caccccggtg acttcaggaa cctgtggcag
     2761 tgcggatcat cccggcggcg ccagcacgac accactgcca cgctcaagcg cgcgtcccgg
     2821 ccctgcatgt ggtaactgca ccagtcccgg gttttcccca tgctgtacct cctgacagaa
     2881 gaagtccgcc acctcctttc aacaaccttc cctccctcct ttactgcgcc ttcgtttcgg
     2941 ctggctgctt ggttagccag tccctcaagg cattcacatc gacactcacc acgaaaagcc
     3001 cgtcaaacag acgagggctc ggcaggatgt ccgccgcaac gacgcaatat cgaagtagta
     3061 gtagaactgg gcagcagagc cagtaggaga ccttggggca aggtgctcag ttgcttcgtc
     3121 ccattgaggc gcatacgggg accaaaaaag gaccaagttg aatggactcc cctgcactca
     3181 cccggacaga tgcgcgcccc gttctcagag ggaaaacggg gatgtgcctc tggtcccgag
     3241 tgaaggcggc ctcgccctcg gcggcttcga ttcccgccgc ctccactccg gatctcccag
     3301 aaaggattca gctttccggg agactgtagc aagagatgta gcaagacccc gggcgccatc
     3361 aggcgcttca cagggctttc ttttcggccg aaactgcaag gggcagccgg acgagatggt
     3421 cgcgctcgtg gcgctggacc ttgagcttgg cgacctcggc gcagagggcc tcccacgtga
     3481 atgagagcgg ggtaacgcca gggctgcccg agccgtgctg ccggtcggtg gagaggccac
     3541 tgggacaccg cacaatgctt gaggagtctt tctaccggcc gttcgcacca ctctggctgc
     3601 accccggcgt ccacgggctc cggcagttgc ggggaccacg cgcacacccc ggagtccccg
     3661 tgaacagctt gccgcacccc gtctggacgg agcgcggcaa gctgtttcga gtctgacacc
     3721 tgcccggctt tgcgtctcct ctccgagccc tggtgaatca tccgggctag tctgcgggcc
     3781 atggccatgc gtcttcccgc tcgcctcgcc catgtcctgc tttccgtcct gctcgcctgc
     3841 gcgtgctctc ccgggtccga gcctggcacc gctcccgatg ccggaggaga caccgcgagc
     3901 gggctggtgc ggctcgaggc gggcttcgag gggacgctgc aaccgcgcgg caacaggctc
     3961 cgcatccacg tgacggacac cgccgggaca ccggtggagg ccacgcgggt ttctgtcagc
     4021 ctgtggatgc ccggacacgg ccatggtgcg cccgcgcccg ccgtcacccg cgaggcgcgc
     4081 ggggactatc tggccactgt ggacttcacc atgccgggca cgtggaccgt caccatccag
     4141 gtggacacgg aggggcgcag cgacaccctc gagttatccg tggaagcccc gtgagcgtgt
     4201 gacgttttgt cgcggagcca cgcccgagcc gctgacgtag ggtgactctc cttccatata
     4261 gctcaaggag aagccatgac gccgaatgac acctcctccg ccccgaacgc cagccctggg
     4321 cagccatccc ggaagctcct gctggccgcc gtggccggcc tcatggggct cggctccgct
     4381 ggctgcggcc agcccgacga gccgcctcct tcccagggcg tacccgatcc ggagccgcag
     4441 gggccccacg tcgtgagccg gagtaccgtc gagggagggc tgaccttcga gcgcttctcc
     4501 gctgactgcg agcagcgcgg cggcttcgtg cagacgcatg ccgtgtgttc tggcaacaac
     4561 tcctgcaaag gcgtctccta caaccgcttc gactactcgc tcacggaaca cacctgcaag
     4621 gcgctcaact cctgcggtgg catgagctgc atcgagctcc ccgcggactc gggcaagacg
     4681 ggcgaggagg tctacaagaa ctcgtgcggc cctgtgtgcc acagtcatac caacaccacg
     4741 gcattcgtgt actacgtggc accgggcacc gctccggaca ccgcccggca gcaattcctc
     4801 agccgttccc ggctctacca gcagtccatc gtggcctttg gcatccacgg gatgagcgcc
     4861 gacggggtcc tgtccgccaa catgcctgcg tttcacgcga agtactcgcg caaggaaatc
     4921 gagcgcgtcg tcgactacgt gcgccagttg gagctcgagg tcgaggccta tgaggtcatg
     4981 gggcccgccg ccccggtccc atgagccgtc cggtccccac gccgagggcg gatgccctgg
     5041 ggctcgggct gcgcctgccc cacctggaag cgctcaagca ggcgtggccg gaatcggtgg
     5101 cctacgtgga aatcatcagc gagaactacc tgggggcggc ggcgcccccc cggaggcacc
     5161 tcgcgtgggt gcgcgagcgc gtgcccgtgg tgctccatgg cgtgggcctg aacctgctgg
     5221 gccatgagcc gctggacgag gcctacctcg acgaggtgtg ccggttggcg gacgcgatgg
     5281 acgctccctt cgtgagcgac cacctgtgct gggtgcgcgc cggaggactg tcgcaccatg
     5341 acctgcttcc aacgcccttc cgggcggatc tgatcgactt cgccgccgag cgggccgcgt
     5401 gggtgcagcg ccggctgggc aggcccttcg ggctggagaa cctctcctcg tacgtttcct
     5461 ttcccgagtc ggacctgacc gagtgggagt tctacgcctc cgtcgtccgg gaggcggggt
     5521 gctacttcat gctcgacctg aacaacatct acgtttcggg gaggaatcac ggcttcgacc
     5581 cccgcggcta cctggatgcc atcgacttcg gccgggtcct ccaggtgcac ctcgcggggc
     5641 acgagcccga gccggacgga acgctcgtgg acacccacgg ccagcccgtg gatggggcgg
     5701 tgtgggagct ctacgcccag gcgtggcgcc ggggagggcc cttcccgacg ctgctggagt
     5761 gggacacgaa cgtgccgcct ctggctcgcg cggtagagga gctggagcgc gccgccgggg
     5821 ttcgcgcgtg agcccctcgc gtgcgccccc ggagtggctc gccggtttcc aggagcggtt
     5881 cggtgccaca ctgcggacgc cactcgatgc ctcgtcgggc acgctgcgcc cggtggagca
     5941 gggcacgggg cgggggctct acaaccggca atactggttc cggctcttcg aggtgctcca
     6001 gggcgagtac ccgctcacgg cccgactcct cgggctgttc ccattcaacc tgctcgtcca
     6061 gcgcttcgcg cgcgagcatc ccccccggga gtgggatctg cggctggcgg gccggggctt
     6121 tggaagctgg ctccggacgc aggtgtcctc gctgcccgcg gggctgcccg ccgcggccct
     6181 cgccgaggcg acggacatcg acacggcctg gagcgaggtg tggatggcgc cggaggtgcc
     6241 cgcctgggct ccctctccag aagagctcgc gacgctcgag gagcggttcc tgcgggcatc
     6301 ccccgcgtgc cgcctgctgg aggagagctg gcccctggtg gcgctccggc ggacgctggg
     6361 gccggacgcg gacgcgcggc gccagcccct gccgcccccc ctccccacgc gccagcactg
     6421 gatgttgctg cgccacgggg aggccctgat ccaggtgccg ctgtccccgg tgagggcgcg
     6481 cctgctatgg gccctgcgca cgaagacgtt cggcgccgcg ctcgcggagg tggaggcgtc
     6541 cctgccgctc tcggagcaag aggcgctcgt ggcgcacatc ggcacatggc tcgccgaggg
     6601 actgcggtgg ggcttctggg tggggacggc cgaccggtag ggcggagcag gcgagggccg
     6661 cgtgcgacac cgtgccgcat tccgtgtacg cagccgcgtg cggtgctgag caccacggcg
     6721 ctccactggc tgccggccga gcggctcgtg gcgctctacc accaaccggg acgactggtg
     6781 cgtccagggg gcatgttcct caacggcgac aacattccgt tctcgcaccg gcccagcccc
     6841 ttccagcggc tggcggagca ggcgcgccgg gcggcagtgt agcttccgct atccgggact
     6901 cgatatcgtt gatgacaacg tgacccatga accaggcacg cgccccaaag gcgcccactg
     6961 gctgaacttc ttacatgaat gtgcttgctc gaatcggact gctcgtgtgg ctctcgtggg
     7021 gcatcggagg ctgcctgctg tccgacgacg tgtgcacccc tgcggacacc acctattcct
     7081 gctgcgtcaa gcagcacctg ggcgatgcct cccagtgcaa cgcgctcgaa gccgaggtga
     7141 gagtcctcga gccgacggtt caccccagta cgccacgcac gcatgggaca gccgtggcgg
     7201 tgggcaccgt ggtcgcggcg gcgacgctct cgtccgatgg ggagatcttc tccgagaaac
     7261 tgcgcgcggc cgtggagaag atcctgcaag aatgcgccat ccaagcacac gagacggtga
     7321 atcgcagacg cattggcgga gacccgaccc gggagcaatg tgaagaaatc ttgaaatggg
     7381 acccgagtgg gcagcccatc acacgggcca tgaaattggg cgaggagaaa cacgccgagg
     7441 ccattgaatg cgccaggaat cgcctgagcc aacttttgcc aggacgcttc agtctggaac
     7501 aacgttatcg tcatactccg acgacaggtc aactcgagtt ggtgagcccg aagcaacacc
     7561 aggagtccat gaggaagaac caagggaggg acatgaaagg aacgctcgtt cctgacatcg
     7621 tcatccacgc ccaaggaaat ccgttgaaga ctcaattcgt ctatgacttc aagttcccgt
     7681 gcctgttcag taatcgcccc aagtggactg tctacaaaga aggtccctac cgggatcaaa
     7741 cccaagggac agtctacgag aaagtcttcg gccccgcgtt acgcgtcaca ccgtgggaga
     7801 tcaattgatg aacggtcgct atcctcattt taaaggccat acaccagccg ggctccatat
     7861 cttgcgcgat gggctcgtca tgaacttctt catccagcgc ccacaccggc agattggagg
     7921 ctccatcgtc cgcgcgttgg cagtctatcg tcaacatgtg ggtttggaga agctgggttt
     7981 ctacacgggt tatgagggat acgacctgcg gctagacgcc aaagcgctca gcgacatcca
     8041 tgaacaattg atcaacgcgg acggctgcgt catccaactc tgggaacatg atgaccagtg
     8101 gagtggatac cggttcgact acaggggccg gatgcttggc acggacacct acatacgttc
     8161 gcccgacgcg gtcagttgtg cttcgttctg gctgcccacc gagtacctgg aagagcaggg
     8221 cccggcacga gtgaaggaac tggcgatggc cctggcgcga gaacttccac tcacctcggg
     8281 ttacgccaat ctcgcattca atggcatgat ggacaccttt cgggtcggtc cgctgattca
     8341 tgacttgtgc ttccgctacc cgggactcga tatcgttgat gacaacgtga cctatgacct
     8401 gggcacgcgc cccaaagggg cctactggct gaacttctac gggcagcccc tcctggacaa
     8461 gctgggcggc gtggcgggac tgcgcgagcg gctgaccctg cccggaatct ccgtcgagca
     8521 attgcagcca gacaaggtcc tggtgcagct cggcgagtgg ccggaagcgg acggcgagct
     8581 gcggccatac cgccaactgg cgcgcgtgct cgagccccac ctctaccagg aggcccgccc
     8641 cgtcctcccc gcggaggtca tgcgccgctg ggagcgccgc ttcctcgact gaagctcact
     8701 tcccgcgcgg agcgtccacg ggttccggca actgcggagc ccacgcgcac accccggagt
     8761 cgccgtgcat ggggacgcag atgtagtccg gggcacacgg gtcttcctct ccgaggctac
     8821 agatgtcgtg gcacgtcccg aacaggcatg cgctgaatcc cgggcacggc gaggcaaagg
     8881 agccctcgcc cgtacacggc gtgacacact ccatccacgc ctctccgggc cggaccggac
     8941 tcgtgtccac cttgcacgtc agtccttccg cgcagggctc acgctggcag ttcgggccat
     9001 gcacccgcgc gcataccgac acgcccggcg tcgcctcccg cacgcactgc tccccctccg
     9061 ggcacacacg gccctcgcac gtgggcaggc acaccggacc gttgggatcg tcctcggcgc
     9121 agaaataccc ttccggacac gagttgaagg gccagagtcc acaccgccgc gcgcaccagt
     9181 ccgcgcacac gagtccccgc tcacaggccc cctcgtcgcg ccggggcagg cgcaaacagg
     9241 actccccctc ctcgcgcacg cccacgaagg tgcaggacgc gatcgccgtc ttcgtcccat
     9301 cccccaccgg gttccaccgg cacaccgatc ccagagcgca atccgcgtcg atgaggcaat
     9361 cactgccatt acatgtctgg cggtcgtagc gccggtccga gaaacaggcc aggggaggat
     9421 cgcactccgc gctgctcgcg caggcctcga ggaacgaggg ccgcgccagg cgctcgtcgg
     9481 gggaaatcat cggcaaccgc cgccacgtcc ccgcccgctg cggcgagacg ctcgtccaca
     9541 acagccccac caggggcaat gccagcaaca cgcccaccgc caccgcgccc cagacccgcc
     9601 cgttcatccg cccacctccc gcctcacgcc acccggcccc gcgtcacccg catgaaggca
     9661 tcctccaggt tgcgctcgcg gtggccgaac gcgcacaccg gcacgcccgc ctccacgagc
     9721 accctcaaca gccgcgccgc cacctcgtct ccccactccg ccgccgcccc ctcctgctcc
     9781 agacgcacgc gcagcgcctg gccctcgcga gcgatctcct tcacgtgggg ctgctcccac
     9841 aacaaccgct cggcacgcgc ccactccgcc tccccctccg ctcctggaaa cagccgcacc
     9901 agcaactcca ccaccgccgt gcccgccgcc tgcgcgagca cgtccgccac cttgcccgtg
     9961 gccaagagcc gcccctgctc gatgatggcg cacgtgtcgc agatctccgc cagctcggtg
    10021 aggatgtggc tggagatgag caccgccttg ccctgatccg cgagcgcgcg cagcagctcg
    10081 cgcagctcga tgcgggcacg cggatccaaa ccgtccgccg gctcgtcgag gatgagcagc
    10141 ttcgggtcat gcaggagcgt gcgcccgagc gccacgcgct gcttcatccc cttggacagc
    10201 gagtgggtga gcttgtccgc caggggtccc aggccggtga actccatcac cgacgccagc
    10261 cgccgcgcgc gcaccgggcc cgtcaggccg taggcgcgcg cgaagaagtc gaggaactcg
    10321 aacacggtga catcttcata ggtgccatag cggtccggca tgtagccgat gagcggccgc
    10381 accttgtccg gcgtgtccac cagcgagtac ccatccagga gcacctcgcc cgcggtgggc
    10441 gtgtccaggg tggcgaggat gcgcatcgtg gtgctcttgc ccgcgccgtt gggcccgatg
    10501 aagccgagga cggtgcccgc ctccagctcg aacgacacgt cgtccaccgc gcgcagggcg
    10561 ccgaagtcgc gccgcagtcc cttcacctcg agcaggctca tccctccacc tcgtctcgcg
    10621 tccgcgtcat ggtccgtcca cccgtccccg caccagatgc gagccctcgt gcaggctcac
    10681 cggaatcgcc gccgagaagg tccaccccgg accctccagc ctcgcgagga accccccctc
    10741 gggcagaggc tcctggaaca ggcgcccgag caccggggag aggcgctgat ccacgtcctt
    10801 ggtggggcgc agctcctcgg tgacgtcgtc c
//
