LOCUS       NZ_CP022098            23231 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6270044
            Orig. end                         :: 6293275
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23231
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="30"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..23231
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13231](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13231
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(99..114)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    1012..1028
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.41"
                     /tool="antismash"
     misc_feature    complement(1479..1492)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    1687..1703
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 25.06"
                     /tool="antismash"
     gene            2265..2891
                     /locus_tag="CYFUS_RS25550"
                     /old_locus_tag="CYFUS_005044"
     CDS             2265..2891
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002632370.1"
                     /locus_tag="CYFUS_RS25550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005044"
                     /product="hypothetical protein"
                     /protein_id="WP_232537828.1"
                     /transl_table=11
                     /translation="MLRQLPLRCFPLTVGLALVSSLVGCAHAPGPREVATAYVRALEEN
                     RLEAASALTSLSPEERATFLTHYADTEARRARIAQVLAALPALRAQGPSLSLIESKDGW
                     RVVEESPQDAPRACLSRFLDATEAADWETAWSLLSSSLRARYTPERLREDFQREPLAAE
                     RVRRARLSVKGPVEVTEEGAAFPLGEQRAVRLTREAGEYRVEALE"
     gene            3019..4107
                     /locus_tag="CYFUS_RS25555"
                     /old_locus_tag="CYFUS_005045"
     CDS             3019..4107
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0140663 - ATP-dependent FeS chaperone
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002632369.1"
                     /locus_tag="CYFUS_RS25555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005045"
                     /product="Mrp/NBP35 family ATP-binding protein"
                     /protein_id="WP_095987607.1"
                     /transl_table=11
                     /translation="MSVSERDILAAMSKVMDPELHIDLVKAGMVKDVRVEGDKAKLKIE
                     LTTPACPMKGKIQADAEAALKQVPGLKTFDIEWGAQVRSAPAGMGGPQGQALLPQVKNV
                     ILVGAGKGGVGKSTVSVNLATALARDGATVGLLDADFYGPSVPLMTGITEKPTSPDGKT
                     LLPMEKHGLKVMSIGFLVEAEQALIWRGPMLHGALMQLIRDVRWGELDYLILDLPPGTG
                     DVALTLSQSVRAAGAVLVTTPQDVALADVVRAKQMFDKVHIPVLGIVENMSQFICPNCS
                     HATHIFNRGGGQKAAQMFSIPFLGEIPLDLKIRESGDAGVPVVLSAPDSPEALAFRTMA
                     RNIAGRVSTENMRVAVKLPVVR"
     gene            4139..4606
                     /locus_tag="CYFUS_RS25560"
                     /old_locus_tag="CYFUS_005046"
     CDS             4139..4606
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002632368.1"
                     /locus_tag="CYFUS_RS25560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005046"
                     /product="hypothetical protein"
                     /protein_id="WP_095987608.1"
                     /transl_table=11
                     /translation="MTTGKEPDKDFDPLLDEGQERGEGSRASFVPEFMRKVAVAGLGAL
                     FMTEEGLRAMAGQLKLPKEVLGYVLGQAEKTKDEVGRVVSEELRRFLQSEKLRDEVLKL
                     LSGMTIEVKAQIRLVPADKDDKEQAEPLRTKIAISELGTRRGGKKAAVKKE"
     gene            4612..5019
                     /locus_tag="CYFUS_RS25565"
                     /old_locus_tag="CYFUS_005047"
     CDS             4612..5019
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS25565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_005047"
                     /product="hypothetical protein"
                     /protein_id="WP_095987609.1"
                     /transl_table=11
                     /translation="MEDEAGRRDWRRHPLVRRLPLLLLLALGLWWWKGSDVPERELVWR
                     LEGPGWSDVRALDVQVKDAEGDLLKRVMLTFPSGPPASLTVKAELAAGTYEVWVFPRGQ
                     HGPSLPPRVERLTLGTEDLRVERNLRMAGSR"
     gene            5085..5933
                     /locus_tag="CYFUS_RS25570"
                     /old_locus_tag="CYFUS_005048"
     CDS             5085..5933
                     /EC_number="1.1.1.157"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553812.1"
                     /locus_tag="CYFUS_RS25570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005048"
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="WP_095987610.1"
                     /transl_table=11
                     /translation="MATEHVVVVGAGQMGSGIAQVALQAGLRVTLVDVSKEGLAKGADR
                     IRAGLKKLAEKGKLDEARLQAAYANLATAERATEVRDVDFAVEAVTENEELKRRIFVEL
                     DGVVKPGGIIATNTSSISITRIAAATKRPENVIGMHFMNPVPIMQLVEIIRGAATSEET
                     YQTTRALAEKMGKTTVVSKDFPGFIVNRILIPMLNEACFALMEGVGSVEDIDTAMKLGT
                     NQPMGPLQLADFIGLDTVLYIAEVLHEGLGDDKYRPSPLLRQYVDAGWYGKKSGRGFYK
                     Y"
     gene            5948..6724
                     /locus_tag="CYFUS_RS25575"
                     /old_locus_tag="CYFUS_005049"
     CDS             5948..6724
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (8-250). E-value: 2e-70. Score:
                     228.9. Matches aSDomain:
                     nrpspksdomains_CYFUS_RS25575_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002639611.1"
                     /locus_tag="CYFUS_RS25575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005049"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_095987611.1"
                     /transl_table=11
                     /translation="MAYENIRLDTEGAVAVLTIDRPKALNALNTQTFLEMESALLLLPS
                     QVRALIVTGGGDKAFVAGADIAEMATIGSAQAREFSALGHRVMHLLERLTIPTIAAVNG
                     FALGGGCELALACDLIYASDKAKLGLPEATLGVIPGFGGTQRLARAVGKMRAKELIFTA
                     DRLDAAKAKEIGLVLEVLPADQLLAHCKAVAAKLIKNGPMALSQAKRVIELGADQDLRT
                     ANELESQAFGVLFGSEDQKEGMKAFLEKRPAVFSGR"
     aSDomain        5972..6697
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CYFUS_RS25575_ECH.1"
                     /evalue="2.00E-70"
                     /label="CYFUS_RS25575_ECH.1"
                     /locus_tag="CYFUS_RS25575"
                     /protein_end="250"
                     /protein_start="8"
                     /score="228.9"
                     /tool="antismash"
                     /translation="DTEGAVAVLTIDRPKALNALNTQTFLEMESALLLLPSQVRALIVT
                     GGGDKAFVAGADIAEMATIGSAQAREFSALGHRVMHLLERLTIPTIAAVNGFALGGGCE
                     LALACDLIYASDKAKLGLPEATLGVIPGFGGTQRLARAVGKMRAKELIFTADRLDAAKA
                     KEIGLVLEVLPADQLLAHCKAVAAKLIKNGPMALSQAKRVIELGADQDLRTANELESQA
                     FGVLFGSEDQKEGMKAFLEK"
     misc_feature    complement(6779..6799)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.56"
                     /tool="antismash"
     gene            6826..7968
                     /locus_tag="CYFUS_RS25580"
                     /old_locus_tag="CYFUS_005050"
     CDS             6826..7968
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002639613.1"
                     /locus_tag="CYFUS_RS25580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005050"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_095987612.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.6e-37, bitscore:
                     127.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.7e-27, bitscore:
                     94.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2e-54, bitscore:
                     183.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFEPSDIQREIQRVCREFAARELTPNARKWDEHHQWPTEAVKKL
                     AELSLMGVAVPEEYGGAGLDNVCYAMAMEEISRGCASTGVIMSVNNSLYCDPVKRYGTE
                     EQKKEFLTPFARGEKLGCFGLTEPEAGSDAAAQKTTAVRKGDEYIINGSKNWITNGPKA
                     DAIVLFTMTNKEAGNRGITAFLVPTNTPGFIRAEPDKKMGISAAHSCSMFFEDMRVPAR
                     NMLGKEGDGFKVAMSTLDGGRIGIAAQALGIARAAFEEAVRYSGERKSFGKPIREHQAI
                     QFMIADMATEIDAARLLVLRAALLKDQGVRHSAESAMAKLYASEMASRVANKALQVHGG
                     MGYSKEMDVERHVRDARITEIYEGTSEIQRIVISANLLKD"
     gene            7983..8474
                     /locus_tag="CYFUS_RS25585"
                     /old_locus_tag="CYFUS_005051"
     CDS             7983..8474
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002632363.1"
                     /locus_tag="CYFUS_RS25585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005051"
                     /product="AgmX/PglI C-terminal domain-containing protein"
                     /protein_id="WP_095987613.1"
                     /transl_table=11
                     /translation="MKRPLITMAVVLSAGLALAQGAAGKKSASVATDAGTPAAEPGGSG
                     KKAAPPARPQPPDVTKLPFTPDSIRMVMNYYSRDIQECYEEILARKGSNVEEGRILTTF
                     TISPDGFVRNAQVAKAGTTIKNERLNECVVNVLTSITFPEPSDKKEHPIEYPFNLKAIK
                     "
     gene            8485..9630
                     /locus_tag="CYFUS_RS25590"
                     /old_locus_tag="CYFUS_005052"
     CDS             8485..9630
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940421.1"
                     /locus_tag="CYFUS_RS25590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005052"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_095987614.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.2e-29, bitscore:
                     102.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.7e-25, bitscore:
                     87.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.4e-51, bitscore:
                     171.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLELTETQTLIRDTARKFARERVAPQARTFDREETFATELYREL
                     ASLGLMGVNISAKYGGAEAGVVAYSLAMMEMSAACASTSVTMAVTNMCAELIHTYGTDA
                     QREKFVTRLTSGEAVAGSFALSEPHAGSDPRAMRTTAVRRGDTWVLNGSKQWITSGEFA
                     GVMVVWAQTGGQGGKGISAFIVEGGTPGLHVGKHEDKMGLRASNTVSLTFEDCAIPADN
                     LLGKEGDGFKLAMIALDGGRIGIASQACGVARAALDASVRYAKDRKAFGQAIGGFQGLS
                     FMMANMATELQAAELLTLRAATLKEEGKPFTREASMAKLFASEMSNRAVDKAVQIHGGY
                     GYIDEFPVERYFRDARVQTIYEGTSEVQRLVIARETFKLFG"
     misc_feature    9706..9723
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     gene            9773..9931
                     /locus_tag="CYFUS_RS50920"
                     /old_locus_tag="CYFUS_005053"
     CDS             9773..9931
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS50920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_005053"
                     /product="hypothetical protein"
                     /protein_id="WP_157758653.1"
                     /transl_table=11
                     /translation="MDHDKKTPKPDSKLSLKKETLRALADSEVSVREGAKAMSFTRPPT
                     WSRPPTW"
     gene            10001..13231
                     /locus_tag="CYFUS_RS25595"
                     /old_locus_tag="CYFUS_005054"
     CDS             10001..13231
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014398018.1"
                     /locus_tag="CYFUS_RS25595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005054"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_095992222.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.4e-177,
                     bitscore: 588.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.9e-07,
                     bitscore: 29.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-66, bitscore:
                     224.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESRPLPSFTASGFFALRTPLLAFDALVEWARGVESADAVSGIT
                     LEDALKRDRRVLRERLMRWVADPVVREALFLASPVLDESLGVWASEPESERGQKVERSL
                     VRYFARMAGRATPFGLFAGLSVGRMDSRTRLCVSERSTLRRHTRLDMDYVCALVEQVRV
                     LPEVRDALLYVPNTSLYRAAGRWRYLEMRVRGRERSYHLVGVEPTPYLDATLEAARDGA
                     KLEALAAGLVASDPEVSLEEALTYLETLVAEQLLVPTWAPPLTGPEPVPYLLEGARDVP
                     GLAPLRQCLSAVHETLSRMDAGAPGHAPELYRELARGLEVLPTPIELPRLFQVDTFRPV
                     SEATLGAQVVEEMLRGVQVLQSITPPEGDEHLLNRFRTLFLERYENRAVPLMEALDEEG
                     GIGFALSRGRGTGTGPLLAGFLFPGEDASGGARSRWESRHQYLLRRLEALWASGLQELV
                     LTPEDLEAMKAPVTSPLPDAFGVVGTVVARSAQAVDQGEFQVTLEQLHGPSGALYLGRF
                     CHGDPQLERCVREHLRAEEALRPDAVFAEIVHLPQGRMGNVICRPQLRRHDIAFLGQSG
                     AERAECISVADLWVSVEGERVVLRSRRLGKEVIPRLSNAHNYASYGLGVYRFLCMMQNP
                     HRMGLRFQWGPLGQARFLPRVVHGRTVLSLATWRVDEETLRQWRKTRGAERFAAVQHLR
                     ARLRLPRWVRLVDEDNRLPVDLDNVLSVETFVHLVKDRSFLQLEELFPGPDALCVEGGD
                     GHYVHEVVVPFVRQASSRGSASSALIPHAVPRRFPPGSEWLYLKLYGGSATLDRLMSGV
                     LGDTLRHVLDSGAVDRWFFLRYEDPNVHLRLRFHGTPARLESEVWPALRAACEASLEEG
                     TGWRVQLDTYEREVERYGGPVGIELAEEIFSADSEAVLALLQAYPGDEGAEVRWRMALK
                     GMDALLEDLGLSLEDKLRVEERARAAFHAEFRVDKRFEEQLAQRYRRESRELEALMAAS
                     PDVRGPARPGLLALRRRGERLRPVVERLRQTEREGRLTVAVERLAESFLHMHVNRLLSE
                     DQRAQELILHDFLVRLYRSRLARMKKDS"
     aSDomain        10517..10777
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CYFUS_RS25595_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-09"
                     /identifier="RREFam001.1"
                     /label="CYFUS_RS25595"
                     /locus_tag="CYFUS_RS25595"
                     /protein_end="259"
                     /protein_start="172"
                     /score="29.3"
                     /tool="antismash"
                     /translation="YVPNTSLYRAAGRWRYLEMRVRGRERSYHLVGVEPTPYLDATLEA
                     ARDGAKLEALAAGLVASDPEVSLEEALTYLETLVAEQLLVPT"
     gene            complement(13242..13934)
                     /locus_tag="CYFUS_RS25600"
                     /old_locus_tag="CYFUS_005055"
     CDS             complement(13242..13934)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002632359.1"
                     /locus_tag="CYFUS_RS25600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005055"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_095987615.1"
                     /transl_table=11
                     /translation="MATRRPTRREKTPRAPRSPSPASSRRRSPEQAREAILEAAEPLLS
                     ERGPDGVGLQAVARAAGVSHALVTHYFGTYEALVREVFQRRARLLADGFWQRMLESREP
                     PDIGQWLELFSPILQDEGNVRLMAWALLTGRGEHLSLDQGPRRVMDVLEAQVGRVAAVQ
                     GQPPPSREALEMTLLVGLCAAQGYTLARHVLLPGLGRTEDAQADARFRAVLAALLDAAL
                     GLEPPRGR"
     gene            14391..16100
                     /locus_tag="CYFUS_RS25605"
                     /old_locus_tag="CYFUS_005056"
     CDS             14391..16100
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002639616.1"
                     /locus_tag="CYFUS_RS25605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005056"
                     /product="30S ribosomal protein S1"
                     /protein_id="WP_002621058.1"
                     /transl_table=11
                     /translation="MQQNVNQQIGEVGDEDFAAMFEASLKERGGEGILKEGEIVKGTVV
                     QVTKDYAIVDIGYKSEGQVPISEFTSPRGEVSVKAGDPVEVLLESRENDTGMVVLSKEK
                     ADKMRIWDEISAACERDEIVKGTIVGRVKGGLSVDIGVKAFLPGSQVDIRPVRNLDQYI
                     SKEFEFKVIKFNKKRGNIVLSRRVLLEKQREEMKKETLKNLKEGAVLKGVVKNLTDYGA
                     FIDLGGIDGLLHITDMSWGRIGHPSEMFNVGDEVRVVVLKFDPAQERVSLGLKQIQEDP
                     WHRADEKYPVGTRVKGKVVSITDYGAFIEIEQGVEGLVHVSEMSWTKRLKHPSKMLEVG
                     QEVEAVVLDIDPKAKRIALGMKQIEQNPWTLLEDKYPIGSVIKGQIRNVTDFGVFVGVE
                     EGVDGLVHVSDISWTQRIKHPGEMFKKGDEVEAVVLNIDVENERFSLGIKQLQPDPWDT
                     LSERTPVGSRVKGKVTKVTDFGAFVEIEPGIEGLVHVSELKEERVENPRDVVQEAQDVE
                     VKIIDINTQDRKVALSMKALIGEGEDYREYLRRQAEGSKARLGDVMASKLKK"
     gene            16326..17504
                     /locus_tag="CYFUS_RS25610"
                     /old_locus_tag="CYFUS_005057"
     CDS             16326..17504
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014397003.1"
                     /locus_tag="CYFUS_RS25610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005057"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_095987616.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 9.2e-05, bitscore:
                     21.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAREVVIVGAARTPIGTFQGSLAKLTAPQLGAIAIKAALERSGVS
                     PDQVSETIMGCVLQAGVGQAPARQAAIFAGIPESVPAVTLNKVCGSGLKAVIAGAQAIA
                     LGDAEVVVAGGMESMSNAPYLSHALRGGARMGHVEFKDALIHDGLWDVYGNVHMGSCAE
                     ECSTSQGIPRSAQDEYALESTRRAIEAQKAGLFTREIVPVTVPGGKGGDVVVSEDDGPK
                     SARPEKIPTLKPVFKKDGTVTAANASSINDGAAALVLMSAERAKAEGRTVLGRITGYAG
                     AARKPVEFTIAPADAINSLLKRAQLKASDVDLWEINEAFAVVAIANNKLLGLDPAKVNP
                     RGGAVVLGHPIGASGARVLVTLLHEMKDLDKKRGVASLCIGGGEGIALMVER"
     gene            17600..18298
                     /locus_tag="CYFUS_RS25615"
                     /old_locus_tag="CYFUS_005058"
     CDS             17600..18298
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553803.1"
                     /locus_tag="CYFUS_RS25615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005058"
                     /product="CoA transferase subunit A"
                     /protein_id="WP_095987617.1"
                     /transl_table=11
                     /translation="MNKIIPSADEAVRDIPDGCTLMSGGFGLCGNPENLIAAIHRKGTK
                     GLTIISNNCGTTELGLGILLNAKQVKKIVASYVGENKEFERQFISKELEVELNPQGTLA
                     ERIRAGGCGIGGFFTPSGAGTELSKGKETRMIDGRLHVLETPLKADFTIVRAWKADTWG
                     NLVFNKTARNFSPMMCMAGRTTIVEAEHIVPAGEIGPDEVHLPGIFVHRIIQAKGLQKW
                     IERRTVQKKA"
     gene            18308..18964
                     /locus_tag="CYFUS_RS25620"
                     /old_locus_tag="CYFUS_005059"
     CDS             18308..18964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553802.1"
                     /locus_tag="CYFUS_RS25620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005059"
                     /product="CoA transferase subunit B"
                     /protein_id="WP_095987618.1"
                     /transl_table=11
                     /translation="MPLNREQIAQRIAQELRDGYYVNLGIGMPTLVANYVPKGMDIMLH
                     SENGILGMGPWPLEGEEDPDLINAGKETVTVVKGAAYFDSALSFGMIRGGHIDMAVLGA
                     MEVSEQGDLANWMIPGKMVKGPGGAMDLAVGAKRVFVAMEHANKEGKSKILKQCTLPLT
                     GLKCVNHIVTEYAFLDVTSEGLVLREVAPGVTVEQVRSLTEASFKTAPDLREMKI"
     gene            18982..20271
                     /locus_tag="CYFUS_RS25625"
                     /old_locus_tag="CYFUS_005060"
     CDS             18982..20271
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002621062.1"
                     /locus_tag="CYFUS_RS25625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005060"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_095987619.1"
                     /transl_table=11
                     /translation="MLPDTPIELTIERLGQLGEGVASYEGRTVFVPGAFPGDRVRVRLE
                     QEGKVMRGHLVGEVLVPSPDRKPSPCAISARCGGCDWLELNESAQRAAKQEIVLSALEH
                     LGHLKRDAFAVRPLLVAPWDFGYRRRAVLHPLKDELTYFGRRSHDRVPVEVCPALMPAL
                     AELPGKLGPLLKPLSREAEEVHLLAEGSKAAFAVLLKGQVAPRYVEACEAAVRALRLEG
                     AVLVPKEGSPRIIGKPVLRSLSPLVPEVPLFLRPDAFSQAHGEANVGLVTAAVHELAPR
                     ETDSVLELYSGNGNFTFPLAASAASVLGVESSSVSVDLAQRSAREGGVANVRFVQGDSR
                     KVCEGLIREGKRFDLALVDPPRTGAPGLAKWLTALGVKRVVYVACDPGALARDAAALAQ
                     AGYAPRALQVVDMFPQTHHVESVMSFERAA"
     gene            20327..21415
                     /locus_tag="CYFUS_RS25630"
                     /old_locus_tag="CYFUS_005061"
     CDS             20327..21415
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022470.4"
                     /locus_tag="CYFUS_RS25630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005061"
                     /product="DUF2855 family protein"
                     /protein_id="WP_198316064.1"
                     /transl_table=11
                     /translation="MSMGWDFLVARDNLERVFLEPSSDPVEQPLAPGEAVLTVERFALT
                     ANNITYGVMGEALGYWRCFPTAPDWRGRIPAWGYARVSRSSSPEAPVGLRFFGLVPMST
                     HFVARLQRTGSGYLDAATHRAGLSPFYNRYTRVEVDESFDNHRALLRPLFTTSFLLDDM
                     LYEAEHAGTRTVILSSASSKTAMGLAWLLSRHGMKVVGLTSRKNLALLGGLGLYQQLVP
                     YDAMAGLWVETPAVFVDFAGDPAVVRGIHRQLKDGLRQSTLVGGTHQRTPPPAKGDPLP
                     GPTPTFFFAPDRLRKRVTDWGLETFESRLAEAMKAFVAASSWLRIEHHRGPEALKAVYR
                     DVVTGQARPEAGHIIWPDPASR"
     gene            21522..22316
                     /locus_tag="CYFUS_RS25635"
                     /old_locus_tag="CYFUS_005062"
     CDS             21522..22316
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022696.4"
                     /locus_tag="CYFUS_RS25635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_005062"
                     /product="DUF3050 domain-containing protein"
                     /protein_id="WP_095987620.1"
                     /transl_table=11
                     /translation="MNPAPLSRLLSATDAPRQALLRHPVYERLSDLNALHTFMGAHVFA
                     VWDFMSLLKTLQRQLTCVEVPWAPPADIECARMINEIVLGEETDEVRPGVYQSHFELYR
                     EAMREVGADEDAVLRFVESLRSGHSLERALEHAPVAARAFVSHTLATTRLRPHQVAAAF
                     LLGRESLLPAVFERILTAVKPLGTGCASLRLYLERHIQLDGEEHGVRAEQLLCRLCGED
                     PERWREAREAALSALRARAELWDGVLGALDATVPSRGRMNVG"
ORIGIN
        1 aaggcgccgc gacggaggac gggcggggcg agtcgatctg ggatcgcttc tccaagacgc
       61 ccggcaaggt gggtgacggg acgaacggcg acgtggcgtg tgatcactat caccgctatc
      121 gcgaggacat cgccctgatg aagagcctgg ggatgcaggc ctaccgcttc tcggtggcgt
      181 ggccgcgcat cctgcccacg ggccggggca aggtgaatca gaaggggctc gacttctaca
      241 accgcctggt ggacgggttg ctcgaggcgg gcatcacccc gttcgtgacg ctctaccact
      301 gggatctccc ccagacgctg caggatcagg gcggctggcc ccggcgctcc accgccgagg
      361 cgttcgtcga gtacacggaa gtcgtcgcgc gcgcgctcgg ggatcgggtg aagaactgga
      421 tcacccacaa cgagccctgg tgcatcagcc tgctcagcca cgagaagggc ctgcacgcgc
      481 cgggcatcaa ggacttccgg ctggcactcg cggcgagcca ccacgtgctg ctgtcgcacg
      541 gctgggcggt gcccgtcatc cgcgccgcga gcccgggcgc ccaggtgggc atcacgctga
      601 acctgtcgcc cgcggagccc gcctcgccga gcgccgccga ctacgacgcg ttccgccacc
      661 acgacggcta cttcaaccgc tggttcctgg atccgctgta cgggcgtcac tacccggcgg
      721 acatgatcgc ggactacatc aaggccggac acctgccgtc cgagggcttc acggtggtgc
      781 agccggggga cctcgaggcg atcgcggtgg acaccgactt cctgggcgtc aactactaca
      841 accgcgcggt gctgcgcagc gacaaggtgt ccgaggagag gaaccacccg cgcacggtgc
      901 acctcgcgcc cgagtcggag tggacggaga tgggctggga ggtccacccg gacagcctgc
      961 gcaagctgct cacgcggctg cacgtcgact acgggccgcg caagttgtac gtgacggaga
     1021 acggggcaag cttctcgacc ccgccggatg cccagggccg ggtgcccgac gtgaagcggc
     1081 tcaacttcct gcgcgaccac ttcctcgcgg cccgcaaggc catggacgcg ggcgcgccgc
     1141 tggccggcta cttcgtctgg tccttcatgg acaacttcga gtgggatcgc ggctacctgc
     1201 agcgcttcgg catcgtctgg gtggactaca agacccagca gcgcatcccc aaggacagcg
     1261 cgctctggta ccgggacgtc atcaaggcca acggcgtgca ggtgccctga gatgccgtca
     1321 agcgcccgag aagacgctgg gcccatcctt catgcacgga cgagttgaag ggctctcctg
     1381 caggtatccg cggcccagct gttgggggga aatctcttgc cgagcaccgt caggagttgg
     1441 aggagggagg gcttcccaca gggcaactct ccgtcccatt gctccggaac aagattcccc
     1501 tgagcgtcgg ggacgcgact cgtcaagccg aacaatgcac cgcattcata acgggtaaag
     1561 gagtcgtcct ggtgcgccgc gcccgacccg cagatggggc aggagccagg gagtcgctcc
     1621 gccttcagct ctcgtaaccg caaccacact ccgattccag actcgggcaa cttgggggcg
     1681 ggtcggttgc tcaccccttg caacagccta ccgacgggga cccactctgg atggcggagg
     1741 caccaactgc ccacgagttc tagcgccctc tcggcggaca cgttccaaca agggggaaca
     1801 gcctcccacc ccctgggctt ctcctgctcc tccggctctg gaggggcgta ggcgcccagg
     1861 caggcgtaga ccaccgtgcc ttccggaaag tccatccccg agttctcggg cgcgatcgga
     1921 gctgaaccac agatggggca gtgagggggc ggctcctcgt tggtcggcag ttctggcagg
     1981 gccgcgctca gacgcaactg ccttgggtcc gagagatccg tcccgggtgg cagatggggg
     2041 aagatggcat ctgtcatgtt cgagtccttc attctggaca gaaccgacaa aagacacctg
     2101 gcgaagcagg caccgcaacc cacttcgagg ggccttgaac cgggcggccc tacatggccg
     2161 cgctgcgtcg cgcgtcgtgg gggtctttcc ccttgagctc gggcgtcgtc tctccagcgg
     2221 cgcggcacgg gggtttccgc taacctcgga ggtccctcgt gcccatgctc cgccagcttc
     2281 ccctccgctg ctttccgctc accgtcggcc tcgcgctggt gtcgtccctc gtgggctgtg
     2341 cccatgctcc gggcccccgc gaggtggcca cggcctatgt ccgggccctg gaggagaacc
     2401 ggctggaggc cgcttccgcc ctgacgagcc tctcccccga ggagcgcgcc acgttcctca
     2461 cgcactacgc ggacacggag gcacggcgcg cccggatcgc ccaggtgctc gcggcccttc
     2521 ccgcgctccg ggcccagggc ccctcgctgt ccctcatcga gtcgaaggat ggctggcggg
     2581 tcgtcgagga gtccccccag gacgcgcccc gggcctgtct gtcgcggttc ctcgacgcga
     2641 cggaggccgc cgactgggag accgcctggt cgctcctgtc ctcctctctg cgggcccggt
     2701 acaccccgga gcggctgcgg gaggacttcc agcgcgagcc cctggcggcc gaacgggtgc
     2761 gccgggcgcg actctcggtg aagggcccgg tggaggtgac ggaggagggg gcggcgttcc
     2821 ccctgggaga gcaacgggcg gtgcggctca cgcgggaagc gggcgagtac cgggtggagg
     2881 cgctcgaatg aggcggcgtg catccgggcc ggtggaagat tagaggaggt tgacaccacc
     2941 gggcccgctg gctattgcgc gccccatccg agggccgtcc cccgccctcg gggttccaca
     3001 aggattcagg tactccagat gagcgtttcc gagcgcgaca tcctcgcggc gatgtcgaag
     3061 gtgatggatc ccgagctgca catcgacctc gtgaaggccg ggatggtcaa ggacgtccgc
     3121 gtggagggcg acaaggcgaa gctgaagatc gagctgacca cgcccgcctg cccgatgaag
     3181 gggaagatcc aggcggacgc ggaagcggcg ctcaagcagg tgccgggcct caagacgttc
     3241 gacatcgagt ggggcgcgca ggtgcgctcg gcgcccgccg gcatgggcgg tccccagggc
     3301 caggcgctgc tgccccaggt gaagaacgtc atcctggtgg gcgcgggcaa gggtggggtg
     3361 ggcaagagca cggtgtcggt gaacctggcc acggccctgg cgcgcgatgg cgccacggtg
     3421 ggcctgctcg acgcggactt ctacggcccg tcggtgcccc tgatgacggg catcaccgag
     3481 aagcccacga gcccggacgg caagacgctg ctgcccatgg agaagcacgg cctcaaggtg
     3541 atgtcgatcg gcttcctcgt ggaggcggag caggcgctca tctggcgtgg gcccatgctg
     3601 cacggggcgc tgatgcagct catccgcgac gtgcgctggg gcgagctgga ctacctcatc
     3661 ctggacctgc ccccgggcac gggcgacgtg gcgctgacgc tgtcccagtc ggtgcgggcc
     3721 gcgggcgcgg tgctggtgac gacgccgcag gacgtggcac tcgcggacgt ggtgcgtgcc
     3781 aagcagatgt tcgacaaggt tcacattccc gtgctgggca tcgtggagaa catgagccag
     3841 ttcatctgcc cgaactgctc gcacgccacg cacatcttca accggggtgg cggccagaag
     3901 gcggcgcaga tgttcagcat ccccttcctg ggagagattc ccctggactt gaagatccgc
     3961 gagtcgggtg acgcgggcgt gcccgtggtg ctcagcgcgc cggacagccc cgaggccctg
     4021 gccttccgga cgatggcgcg caacatcgcc ggccgcgtct ccaccgagaa catgcgcgtg
     4081 gcggtgaagc tcccggtggt acgctagtcg cctccccgtc cccccacgag gccccccgat
     4141 gacgaccggc aaggaacccg acaaggactt cgatccgctg ctcgacgaag ggcaggagcg
     4201 gggagagggg tctcgcgcga gtttcgtgcc cgagttcatg cgcaaggtgg ccgtggcggg
     4261 gctgggcgcc ctcttcatga cggaggaggg gctgcgcgcg atggccggcc agctcaagct
     4321 gcccaaggag gtgctcggct acgtgctcgg gcaggcggag aagacgaagg acgaggtggg
     4381 tcgggtcgtc tccgaggagc tgcggcgctt cctccagtcg gagaagctgc gcgacgaggt
     4441 gctcaagctc ctgtcgggga tgaccatcga ggtgaaggcg cagatccgcc tggtgcccgc
     4501 ggacaaggac gacaaggagc aggccgagcc cctgcgcacc aagatcgcca tctccgagct
     4561 gggcacgcgc cgcggcggca agaaggccgc cgtgaagaag gagtagggcg ggtggaggac
     4621 gaggcggggc ggagggactg gcgtcggcat cccctcgtgc ggcggctgcc gttgctgctg
     4681 ctgctggcgc tgggcctgtg gtggtggaag ggctcggacg tgcccgagcg cgagctggtg
     4741 tggcggctgg agggcccggg ttggagtgac gtccgcgcgc tcgacgtgca ggtgaaggac
     4801 gcggagggcg acctgctcaa gcgcgtgatg ctcaccttcc cgagcggccc cccggcgtca
     4861 ctcaccgtga aggcggaact ggccgccggg acgtacgagg tctgggtgtt tccccgggga
     4921 cagcacggac cgtccctgcc gccccgagtg gagcgcctga cacttggaac cgaggatctc
     4981 cgggtggagc ggaacctgag gatggccggg agtcgttgac cggtgggggg gcgggggcta
     5041 tagcccgccc ggttccaaac cgctcgaaag aggtcgcgaa cgccatggca acggagcacg
     5101 tcgtcgtcgt cggggcagga cagatggggt cgggcatcgc ccaggtggcg ttgcaggcgg
     5161 gcctgcgcgt cacgctggtg gatgtgtcga aggagggtct cgccaagggg gccgatcgca
     5221 tccgcgcggg cctcaagaag ctcgcggaga agggcaagct ggacgaggcc cggctccagg
     5281 cggcgtacgc gaacctggcc accgccgagc gcgccaccga ggtgcgggac gtggacttcg
     5341 ccgtcgaggc ggtgacggag aacgaggagc tcaagcgccg catcttcgtg gagctggacg
     5401 gcgtggtgaa gccggggggc atcatcgcca ccaacacctc gtccatctcc atcacccgca
     5461 tcgccgcggc gaccaagcgc cccgagaacg tcatcggcat gcacttcatg aacccggtgc
     5521 cgatcatgca gctggtggag atcatccggg gcgcggccac ctccgaggag acgtaccaga
     5581 cgacgcgggc gctcgcggag aagatgggca agacgacggt ggtgtccaag gacttcccgg
     5641 gcttcatcgt caaccgcatc ctcatcccca tgctcaacga ggcgtgcttc gcgctgatgg
     5701 agggtgtggg ctcggtggag gacatcgaca cggcgatgaa gctgggcacc aaccagccca
     5761 tgggcccgct gcagctcgcg gacttcatcg gcctggacac cgtgctctac atcgccgagg
     5821 tgctccacga gggcctgggc gacgacaagt accgcccgag ccccctgctg cgtcagtacg
     5881 tggacgcggg ctggtacggc aagaagagcg gccgcggttt ctacaagtac taggacggga
     5941 caacaccatg gcctacgaga acatccggct ggacaccgag ggcgccgtcg ccgtcctcac
     6001 catcgaccgc cccaaggcgc tcaacgccct caacacccag acgttcctcg agatggagtc
     6061 ggcgctgctg ctcctgccct cgcaggtgcg cgcgctcatc gtcaccggcg ggggcgacaa
     6121 ggccttcgtg gcgggggcgg acatcgcgga gatggccacc atcggctcgg cacaggcgcg
     6181 ggagttctcc gcgctcggcc accgcgtcat gcacctgctc gagcggctca ccatcccgac
     6241 gatcgccgcg gtgaacggct tcgcgctcgg cggcgggtgt gagctcgcgc tcgcgtgcga
     6301 cctcatctac gcgtcggaca aggcgaagct ggggctgccc gaggccaccc tcggcgtcat
     6361 cccgggcttt ggcggcaccc agcgcctggc gcgcgcggtg ggcaagatgc gcgcgaagga
     6421 gctcatcttc accgccgacc ggctggacgc ggccaaggcc aaggagattg gcctcgtgct
     6481 cgaggtgctc ccggccgacc agctcctcgc gcactgcaag gcggtggcgg ccaagctcat
     6541 caagaacggc ccgatggccc tctcccaggc caagcgcgtc atcgagctgg gcgccgatca
     6601 ggatctccgc acggccaacg agctggagag ccaggcgttc ggagtgctct tcggctccga
     6661 ggaccagaag gaaggcatga aggccttcct cgagaagcgc ccggcggtct tctccggccg
     6721 gtagacggcc cggcgggtgc tcgggcgccc cgcctttcag ccaaccctgt atccgggaca
     6781 catggcccat actatgtacc cggcgtcttt ctccccagga gtgccatgaa cttcgagccg
     6841 agcgacatcc agcgtgagat ccagcgggta tgccgcgagt tcgccgcgcg cgagctgacc
     6901 cccaacgccc gcaagtggga cgagcaccac cagtggccca ccgaggcggt gaagaagctc
     6961 gcggaactgt ccctgatggg cgtggcggtg cccgaggagt acggcggcgc gggcctggac
     7021 aacgtctgct acgccatggc catggaggag atcagccgcg gctgcgcctc cacgggcgtc
     7081 atcatgagcg tgaacaactc gctctactgc gatccggtca agcgctacgg caccgaggag
     7141 cagaagaagg agttcctcac gccgttcgcc cggggcgaga agctcggctg cttcggcctc
     7201 accgagcccg aggcgggcag cgacgctgcc gcccagaaga ccacggcggt gcgcaagggt
     7261 gacgagtaca tcatcaacgg ctcgaagaac tggatcacca acggccccaa ggccgacgcc
     7321 atcgtgctgt tcacgatgac gaacaaggaa gcgggcaacc ggggcatcac cgcgttcctg
     7381 gtgcccacca acaccccggg cttcatccgg gccgagcccg acaagaagat gggcatcagc
     7441 gcggcgcact cgtgcagcat gttcttcgag gacatgcgcg tgccggcccg gaacatgctg
     7501 ggcaaggagg gcgatggctt caaggtggcg atgagcacgc tggacggcgg gcgcatcggc
     7561 atcgcggcgc aggcgctggg cattgcgcgt gcggccttcg aggaggcggt gcgctactcg
     7621 ggcgagcgca agagcttcgg caagcccatc cgcgagcacc aggccatcca gttcatgatc
     7681 gccgacatgg ccacggagat cgacgcggcg cgcctgctgg tgctgcgcgc ggcgctgctc
     7741 aaggatcagg gcgtgcgcca ctccgccgag agcgccatgg ccaagctcta cgcgagcgag
     7801 atggccagcc gcgtggcgaa caaggccctg caggtgcacg gcggcatggg ctactcgaag
     7861 gagatggacg tggagcgcca cgtgcgcgac gcgcgcatca ccgaaatcta cgaggggacg
     7921 agcgagatcc agcgcatcgt catctcggcc aacctgctca aggactaggg agtcgacgac
     7981 ccatgaagcg accgttgatc acgatggcgg tggtgttgtc ggccggcctg gcgctggcgc
     8041 agggcgcggc gggcaagaag agcgcatccg tggccacgga cgcgggaacc ccggccgccg
     8101 agccgggtgg ctcggggaag aaggccgcgc cgccggcccg gccgcagccg ccggacgtca
     8161 ccaagctgcc cttcaccccg gactccatcc gcatggtgat gaactactac tcgcgggaca
     8221 tccaggagtg ctacgaggag atcctcgcga ggaagggcag caatgtggag gagggccgca
     8281 tcctgacgac cttcaccatt tctcccgacg gcttcgtgcg caacgcccag gtggccaagg
     8341 cgggcacgac gatcaagaac gagcggctca acgagtgcgt ggtgaacgtg ctcaccagca
     8401 tcacgttccc cgagccctcg gacaagaaag agcacccgat cgagtacccg ttcaacctca
     8461 aggccatcaa gtaggaagcc ccccgtgaac ctcgaactca ccgagaccca gacgctcatc
     8521 cgggacaccg cgcgcaagtt cgcgcgcgag cgggtggcgc cccaggcgcg caccttcgat
     8581 cgggaggaga ccttcgccac ggagctgtac cgggagctgg cctcgctggg gctcatgggg
     8641 gtgaacatct ccgcgaagta tgggggcgcc gaggcgggcg tcgtggcgta ctcgctggcg
     8701 atgatggaga tgtcggcggc gtgcgcgtcg acgtcggtga ccatggccgt caccaacatg
     8761 tgcgccgagc tcatccacac gtacggcacc gacgcgcagc gcgagaagtt cgtgacgcgg
     8821 ctgacgtcgg gcgaggcggt ggcgggctcg ttcgcgctct ccgagccgca cgcgggctcg
     8881 gatccgcgcg ccatgcgcac cacggcggtg cggcgtgggg acacgtgggt gctcaacggc
     8941 agcaagcagt ggatcacctc gggtgagttc gcgggggtga tggtggtgtg ggcgcagacg
     9001 ggagggcagg ggggcaaggg catctccgcc ttcatcgtgg agggcggcac gccggggctg
     9061 cacgtgggca agcacgagga caagatgggc ctgcgcgcgt ccaacacggt gagcctcacc
     9121 ttcgaggact gcgccattcc cgcggacaac ctcctgggca aggaggggga tggcttcaag
     9181 ctggcgatga tcgccctgga cggtgggcgg attggaatcg cctcgcaggc gtgtggcgtg
     9241 gcccgggcgg cgctggacgc gagcgtgcgc tacgcgaagg accgcaaggc gttcggccag
     9301 gcgattggag ggttccaggg cctgagcttc atgatggcga acatggccac ggagcttcag
     9361 gcggcggagc tgctcacgct gcgcgcggcg accctcaagg aggagggcaa gccgttcacc
     9421 cgcgaggcgt ccatggcgaa gctgttcgcc agcgagatgt ccaaccgcgc ggtggacaag
     9481 gcggtgcaga tccacggcgg ctacggctac atcgacgagt tccccgtgga gcgctacttc
     9541 cgcgacgccc gcgtgcagac catctacgag ggcaccagcg aggtgcagcg cctcgtcatc
     9601 gcccgcgaga cgttcaagct gttcggctga agcgcggagg tgacacgtca ctcgtcgagc
     9661 ccatcgggga acggctcctc gtcagtcatt gcatcggtat tgtaactgtt gacagggtgt
     9721 gaagggtttt ttactctttc ctgagttccc cgttgttctc ccggaggaag tcatggacca
     9781 cgacaagaag acgcccaagc cggactcgaa gctgtcgctc aagaaggaga cgctgcgcgc
     9841 tctcgccgat tccgaggtct cggtgcgcga aggcgcgaag gcgatgagct ttactcgtcc
     9901 tccgacgtgg tctcgtcctc cgacgtggtg agctgaagtg gtgggaacag cctgagtgag
     9961 cactcctgct cctcggctgt tgcccctcgt gaccgcgtcc atgactgaat cccggccact
    10021 gccgagcttt accgcttcgg gattcttcgc cctccgcacc cccctgcttg cctttgacgc
    10081 cctcgtggag tgggcccggg gagtggagtc ggccgacgcg gtctctggaa tcaccctgga
    10141 agatgcactg aagcgggacc ggcgcgtgct gcgtgagcgg ctgatgcgct gggtcgcgga
    10201 tcccgtggtg cgcgaggccc tcttcctcgc ctcaccggtg ctcgacgaga gcctgggcgt
    10261 gtgggcgtcc gagccggagt cggagcgcgg acagaaggtg gagcgctccc tggtgcgcta
    10321 tttcgcgcgc atggcgggcc gcgccacccc cttcggattg ttcgcgggcc tctccgtggg
    10381 ccggatggat tcacggaccc ggttgtgtgt ctccgagcgc tccactcttc gccgccacac
    10441 ccggctggac atggactacg tctgtgccct ggtagagcag gtacgcgtcc tccccgaggt
    10501 ccgcgatgcc ttgctctacg tgcccaacac cagtctctac cgtgccgcgg gacggtggcg
    10561 ctatctggag atgcgggtgc gcgggcgcga gcgctcctat cacctggttg gcgtggagcc
    10621 cacgccctat ctggatgcca cgctggaggc ggcccgggac ggcgcgaagc tggaggcact
    10681 ggcggccggg ctggtggcga gtgatcccga ggtgtcgctc gaggaggccc tgacctacct
    10741 cgagacgttg gtggccgagc agctcctggt tcccacctgg gcgccccctc tgactggccc
    10801 cgagcccgtg ccctacctgc tcgagggcgc gcgggacgtg cccggtctgg cccccctgag
    10861 gcagtgcttg tccgccgtcc acgagaccct gtcccggatg gatgccggag ccccggggca
    10921 tgcgcccgag ctctatcgcg agctggcacg tggcctggag gtcctgccca ctcccatcga
    10981 gctgccccgc ctcttccagg tggacacctt ccggccagtg tccgaggcca ccctgggtgc
    11041 gcaggtggtg gaggagatgc tgcgcggcgt ccaggtgctc cagtccatca ctccgcccga
    11101 gggcgacgaa cacctgctca accgcttccg caccctcttc ctcgagcgct atgagaaccg
    11161 cgcggtgccg ctgatggagg cgctggacga ggagggtggc atcggcttcg cgctctcccg
    11221 gggacggggg acggggaccg gccccttgct ggcgggcttc ctctttcccg gggaggacgc
    11281 gagcggcggc gcgcggagcc gttgggagtc ccgccatcag tacctgctgc gccgactgga
    11341 ggcgctctgg gcctcggggc tccaggaact ggtgctcact ccagaggatc tggaggccat
    11401 gaaggctccg gtgaccagcc ccctgccgga tgccttcggg gtggtgggca cggtggtggc
    11461 ccgctccgcc caggcggtgg accagggcga gttccaggta accctcgagc aacttcatgg
    11521 tccctcgggt gccctgtacc tgggacgctt ctgccacgga gatccacagc tggagcgctg
    11581 cgtgcgcgag cacctgcgcg ccgaggaggc cctgcggccg gacgccgtct tcgcggagat
    11641 cgtccatctg ccgcagggcc gcatgggcaa cgtcatctgc aggccccagc tgcggcgcca
    11701 cgacatcgcc ttcctcgggc agtcgggcgc cgagagagcc gaatgcatct ccgtggcgga
    11761 tctctgggtc tccgtggagg gggagcgcgt cgtcctgcgc tcgcggcgcc tgggcaagga
    11821 ggtcatcccc cggctgagca acgcccacaa ctacgcgtcc tatggtctgg gcgtgtaccg
    11881 cttcttgtgc atgatgcaga acccccaccg catggggctt cgcttccaat ggggtcccct
    11941 gggacaggcg cgtttcctgc ctcgggtggt ccatggtcga accgtgctct cgctggcgac
    12001 gtggcgcgtg gacgaagaga ccctgcggca gtggaggaag acgcggggcg ccgagcgctt
    12061 cgccgccgtc cagcacctgc gggctcggct ccgactgccg cgctgggtgc gtctggtgga
    12121 cgaggacaac cggttgcccg tggatctgga caatgtcctg agcgtggaga cgttcgtgca
    12181 tctggtgaag gaccgctcct tcctccaact ggaggagctc ttcccgggtc ccgacgcgct
    12241 ctgcgtggag ggcggggatg gccactacgt gcatgaggtg gtggtgccct tcgtccgcca
    12301 ggcctcctcc aggggctccg cttcatcggc gctcattccc cacgccgtgc cccgccgctt
    12361 tcctccgggc tccgagtggc tgtatctcaa gctgtacggc ggctcggcca cgctggatcg
    12421 gttgatgagc ggcgtgctgg gagacaccct gcgccatgtg ctggattcgg gggcggtgga
    12481 tcgctggttc ttcctgcgct acgaggatcc gaacgtgcac ctgcggctgc gcttccacgg
    12541 gacgcccgcg cgcctggagt cggaggtgtg gcccgcgctg cgcgccgcgt gcgaggccag
    12601 tctggaggag gggacgggtt ggcgtgtgca gctcgacacc tacgagcgcg aagtggagcg
    12661 ctatggcgga ccggtcggca tcgaactggc cgaggaaatc ttcagcgccg acagcgaggc
    12721 cgtgctggca ttgctccagg cctaccccgg ggatgaaggg gcggaagtgc gctggcgcat
    12781 ggccctcaag ggcatggatg cgctgctgga ggacctggga ctgagcttgg aggacaagtt
    12841 gcgtgtggaa gagcgggccc gcgcggcctt ccatgccgag ttccgggtgg acaagcgttt
    12901 cgaggagcag cttgctcagc gctaccgccg ggagagccgg gaattggagg ccctgatggc
    12961 ggcttccccg gatgtacgcg gtccagcgcg gccggggttg ctggcgttgc ggcgccgcgg
    13021 cgagcggctg cggcccgtgg tggaacgact gcgccagacc gagcgggagg gccgtctcac
    13081 cgtcgcggtg gaacggctgg cggagagctt cctccacatg cacgtcaacc gcctgctgtc
    13141 ggaggatcaa cgcgcccagg aactcatcct ccatgatttc ctggtgcggc tgtaccgttc
    13201 ccgtctggcg cggatgaaga aggactcctg agcgaggacc ttcagcgccc tcggggaggt
    13261 tccaatccga gggcggcatc gaggagcgcg gcgagcacgg cgcgaaagcg cgcgtcggcc
    13321 tgagcgtcct cggttcgccc gagccccggc agcagcacgt gccgggcgag cgtgtacccc
    13381 tgcgccgcgc acagtcccac gagcagcgtc atctccaggg cctcgcgaga ggggggcggc
    13441 tgcccttgca cggcagcgac ccggcccacc tgcgcctcca gcacatccat cacccggcgc
    13501 ggaccctggt ccagggacag gtgctcgccg cgcccggtga gcagcgccca cgccatcagc
    13561 cggacgttcc cctcgtcctg gaggatcggc gagaagagct ccaaccactg gccgatgtcg
    13621 gggggctccc tggactcgag catccgttgc cagaagccat ccgccagcag ccgggcccga
    13681 cgctggaaca cctcgcgcac cagcgcctcg taggtgccga agtagtgcgt gacgagcgca
    13741 tggctcaccc ccgcggcgcg cgccaccgct tgcagtccca ccccgtccgg cccccgttca
    13801 ctcagcagcg gctcggccgc ctcgaggatg gcctcccgcg cctgctccgg ggagcggcgc
    13861 cgcgaggacg cgggggaggg ggagcgggga gcacgcggag tcttctcgcg gcgggtgggg
    13921 cgcctggtgg ccatcgcgca cgaacctacc ttccgccccc tcccgccatg cgtccctcat
    13981 tggcggggat gacaacgagc cgacgcttgt tggcagccgt gacagcgaat gcgcgcgaaa
    14041 aacccggggt ccgctctgga tccgagccgc tcggctgatc gccctgcgac cagggaccaa
    14101 tgatccgcat gcatcgagac ccaccaggac ctacagtccc gccaaggcac gaaacctcct
    14161 tatgagcctc ttcgtgggtc acgaaggacg cttggcgccg cgacggtatt gacagatcca
    14221 gaagcctggc cgcgtgctcc cttgactgcc ggtccaaccg gtgtctaggg tgcgcggctt
    14281 cgagtcagct ccactgtggt gctgatcgcg ggccactcgt agctccccgc gagtggccga
    14341 cgtccaacaa ccgggggcag tagcaccgtt tcccaaggat tccctaccaa atgcagcaga
    14401 atgtgaacca gcagatcgga gaggtcggcg acgaggattt tgccgcgatg ttcgaggcct
    14461 cgctcaagga gcgagggggc gaaggcatcc tcaaggaagg cgagatcgtc aagggcaccg
    14521 tcgttcaggt gaccaaggac tatgccatcg tcgacatcgg ctacaagtcc gagggccagg
    14581 ttccgatctc cgagttcacc agccctcgtg gcgaggtctc cgtcaaggcg ggcgacccgg
    14641 tcgaggtcct cctggagagc cgcgagaacg acaccggcat ggtcgtcctc tccaaggaga
    14701 aggccgacaa gatgcgtatc tgggacgaga tcagcgccgc gtgcgagcgc gatgagatcg
    14761 tcaagggcac catcgtgggc cgcgtgaagg gtggcctctc ggtcgacatc ggcgtcaagg
    14821 cgttcctgcc cggcagccag gtggatatcc gcccggtgcg caacctcgac cagtacatct
    14881 cgaaggaatt cgagttcaag gtcatcaagt tcaacaagaa gcgcggcaac atcgtgctct
    14941 cccgccgcgt gctgctcgag aagcagcgcg aggagatgaa gaaggagacc ctcaagaacc
    15001 tcaaggaggg tgcggtcctc aagggcgtgg tcaagaacct caccgactac ggcgccttca
    15061 tcgacctggg cggcatcgac ggcctgctcc acatcaccga catgtcgtgg ggccgcatcg
    15121 gtcacccctc cgagatgttc aacgtgggcg atgaggtccg cgtcgtcgtc ctcaagttcg
    15181 accccgcgca ggagcgcgtc agcctgggcc tgaagcagat ccaggaggat ccgtggcacc
    15241 gcgccgacga gaagtacccg gtcggcacgc gcgtcaaggg caaggtcgtc tccatcaccg
    15301 actacggcgc gttcatcgag atcgagcagg gcgtcgaggg tctggtgcac gtgtccgaga
    15361 tgtcctggac caagcgcctc aagcacccga gcaagatgct ggaggtcggc caggaggtcg
    15421 aggccgtcgt cctcgacatc gatcccaagg ccaagcgcat cgcgctcggc atgaagcaga
    15481 tcgagcagaa cccctggacg ctgctcgagg acaagtaccc gatcggctcg gtcatcaagg
    15541 gtcagatccg caacgtcacc gacttcggcg tgttcgtcgg cgtcgaggag ggcgtggacg
    15601 gcctggtgca cgtgtccgac atctcgtgga cccagcgcat caagcacccg ggcgagatgt
    15661 tcaagaaggg cgacgaggtc gaggcggtgg tgctcaacat cgacgtcgag aacgagcgct
    15721 tcagcctggg catcaagcag ctccagccgg acccctggga cacgctcagc gagcgcaccc
    15781 cggtgggcag ccgcgtgaag ggcaaggtca ccaaggtgac ggacttcggc gccttcgtgg
    15841 agatcgagcc cggcatcgag ggcctcgtgc acgtctccga gctgaaggag gagcgtgtcg
    15901 agaacccgcg tgacgtggtg caggaggccc aggatgtcga ggtgaagatc atcgacatca
    15961 acacccagga ccggaaggtc gccctgtcga tgaaggccct catcggcgag ggtgaggact
    16021 accgcgagta cctccgccgc caggccgagg gatccaaggc gcgcctcggc gacgtcatgg
    16081 cgagcaagct caagaagtag tcggcttcat ccctcgcacg agggatggca cggcggccgg
    16141 gttccccagc gggagcccgg ccgtttgttt tcacgcactc gtgcgaggct gacctcgtgc
    16201 gtcatgacgg agagggggga agtgggcttg accccctcgg gaggcacggt gataagggcc
    16261 gtgcccgagg ttattgaacc tcgtcctttt tcagcttttc tcagcactct ccccggaggc
    16321 ggatcatggc acgtgaagtg gtcatcgtgg gcgcggcgcg aactcccatt gggacgtttc
    16381 agggctccct cgccaaactg accgcaccgc agctcggcgc gatcgccatc aaggccgccc
    16441 tggagcgctc gggcgtgtcg cccgaccagg tgagcgagac catcatgggc tgcgtgctcc
    16501 aggcgggcgt ggggcaggct cccgcgcgtc aggccgccat cttcgcgggc atcccggaga
    16561 gcgtccccgc ggtcaccctc aacaaggtgt gcggctcggg cctcaaggcg gtgatcgccg
    16621 gcgcccaggc catcgcgctc ggtgacgccg aggtggtggt ggccggcggc atggagtcca
    16681 tgagcaacgc gccctacctg agccacgccc tgcgcggcgg cgcccgcatg ggccacgtgg
    16741 agttcaagga cgcgctcatc catgacggcc tgtgggacgt gtacggcaac gtgcacatgg
    16801 gtagctgcgc cgaggagtgc tcgaccagcc agggcattcc ccgctcggcc caggacgagt
    16861 acgcgctcga gtccacccgg cgcgccatcg aggcccagaa ggccggcctg ttcacgcgtg
    16921 aaatcgttcc cgtcaccgtg cccggcggca agggcggcga cgtggtggtg agcgaggacg
    16981 acggccccaa gagcgcccgg ccggagaaga tccccacgct caagcccgtg ttcaagaagg
    17041 acggcacggt gacggccgcc aacgcctcgt ccatcaacga cggcgccgcg gcgctggtgc
    17101 tcatgagcgc cgagcgcgcc aaggccgagg gccgcacggt gctcggccgc atcaccggct
    17161 atgccggggc cgcgcgcaag ccggtggagt tcaccatcgc ccccgcggac gccatcaact
    17221 ccctgctcaa gcgcgcccag ctcaaggcca gcgacgtgga cctgtgggag atcaacgagg
    17281 ccttcgccgt ggtggccatc gccaacaaca agctgctcgg cctggatccc gccaaggtca
    17341 atccccgcgg cggcgcggtg gtgctcggcc accccattgg cgcctcgggc gcgcgcgtgc
    17401 tggtgacgct gctgcacgag atgaaggacc tggacaagaa gcggggcgtg gcgtcgctgt
    17461 gcattggtgg cggcgagggc atcgcgctga tggtggagcg ctaatccata cggactcgct
    17521 ctcccacggg gagaggaggg cggggcgggg gcccgacgtg agcaaggccc tggccccgtt
    17581 ctcatgaagg aggggtttca tgaacaagat catcccgagc gcggacgagg ccgttcgcga
    17641 catcccggat ggctgtacgc tgatgagtgg cggcttcggc ctgtgtggca atcccgagaa
    17701 cctgatcgcg gccatccacc gcaagggcac caaggggttg accatcatct ccaacaactg
    17761 cggcaccacc gagctggggt tggggatcct cctcaacgcg aagcaggtga agaagatcgt
    17821 cgccagctac gtgggggaga acaaggagtt cgagcggcag ttcatctcca aggagctgga
    17881 ggtggagctc aacccccagg gcacgctcgc cgagcgcatc cgcgccggag gctgcggcat
    17941 cggcggcttc ttcacgccgt cgggcgcggg caccgagctg tccaagggca aggagacccg
    18001 gatgatcgac gggcgcctgc acgtgctgga gacgccgctc aaggcggact tcaccatcgt
    18061 gcgcgcgtgg aaggcggaca cctggggcaa cctggtgttc aacaagaccg cccgtaactt
    18121 ctcgccgatg atgtgcatgg cgggcaggac gacgatcgtc gaggccgagc acatcgtgcc
    18181 ggccggggag atcggcccgg atgaggtgca cctgcccggc atcttcgtgc accgcatcat
    18241 ccaggccaag ggcctgcaga agtggatcga gcgccgtacc gtgcagaaga aggcttgaga
    18301 ggacgccatg cccctgaacc gtgagcagat cgcccagcgc atcgcccagg agctgcgcga
    18361 tggctattac gtgaacctgg gaatcggcat gccgaccctg gtggccaact acgtcccgaa
    18421 gggcatggac atcatgctcc actcggagaa cggcatcctc ggcatgggcc cctggcccct
    18481 ggagggtgaa gaggatccgg acctcatcaa cgccggcaag gagacggtga ccgtggtcaa
    18541 gggcgccgcc tacttcgact cggcgctgtc cttcgggatg atccgcggag gccacatcga
    18601 catggccgtg ctcggcgcca tggaggtgag cgagcagggt gacctggcca actggatgat
    18661 ccccggcaag atggtgaagg gcccgggggg cgccatggat ctggcggtgg gcgccaagcg
    18721 cgtcttcgtg gccatggagc acgccaacaa ggagggcaag tcgaagatcc tcaagcagtg
    18781 cacgctgccc ctcaccggcc tcaagtgcgt caaccacatc gtcaccgagt acgccttcct
    18841 ggatgtcacc tccgaggggc tcgtgctgcg cgaggtggcc cccggtgtga cggtggagca
    18901 ggtgcgctcg ctcaccgagg cctcgttcaa gaccgctccg gatcttcgcg agatgaagat
    18961 ctgaagacgc tccccgctcc cgtgctgccg gacactccca tcgagttgac catcgagcgc
    19021 ctcgggcaac tgggcgaggg tgtggcctcc tacgagggcc gcaccgtctt cgtgcccggg
    19081 gcgtttcccg gagaccgggt gcgcgtgcgc ctggagcagg agggaaaggt gatgcgcggg
    19141 cacctcgtgg gcgaggtgct ggtgccgtca cccgatcgca agccctcgcc ctgcgcgatc
    19201 agcgcgcggt gcgggggctg tgactggctg gagctgaacg agtccgccca gcgcgccgcg
    19261 aagcaggaga tcgtcctctc cgcgctcgag cacctgggcc acctgaagcg ggatgccttc
    19321 gccgtgcggc cgctgctcgt ggcgccgtgg gacttcggct accggcggcg cgcggtgctg
    19381 catccactca aggacgagct gacgtatttc gggcggcgca gtcatgaccg ggtgccggtg
    19441 gaggtgtgcc ccgcgttgat gccggcgctc gccgagttgc ccggcaagct cgggccgctg
    19501 ctcaagccct tgtcccgcga ggccgaggag gtgcacctgc tggccgaggg gagcaaggcc
    19561 gccttcgcgg tgctgctcaa ggggcaggtg gcgccccggt acgtcgaggc gtgcgaggcc
    19621 gcggtgcgtg cgctgcggct ggagggcgcg gtgctggtgc cgaaggaagg ctcgccgcgg
    19681 atcatcggca agcccgtgct gcgctcgctg tcgccgctgg tgcccgaggt gccgctgttc
    19741 ctgcgtccgg acgcgttctc ccaggcgcat ggcgaggcca acgtggggct cgtcacggcg
    19801 gccgtgcacg agctggcccc gcgcgagacg gactcggtgc tggagctgta ctcgggcaat
    19861 ggcaacttca ccttcccgct cgcggcgagc gcggcgagtg tgctcggggt ggagtcgtcc
    19921 tcggtctcgg tggacctggc ccagcgcagc gcgcgcgagg gcggggtggc caacgtacgc
    19981 ttcgtccagg gggactcccg caaggtgtgc gaggggctca tccgcgaggg caagcgcttc
    20041 gatctggccc tggtggatcc tccccgcacc ggtgcgccgg ggctcgcgaa gtggctcacc
    20101 gcactggggg tgaagcgcgt ggtgtacgtg gcgtgtgatc ccggcgcgct ggcgcgggac
    20161 gcggcggccc tcgcgcaggc gggctatgca ccccgggcgc tccaggtggt ggacatgttc
    20221 ccccagacgc accacgtgga atccgtgatg tctttcgagc gggcggcgta gagtcaccct
    20281 tcggacttca cgctccccac gagcaatcag agaagggtgt gtctgcatgt cgatgggttg
    20341 ggacttcctg gtcgcgcgag acaatctgga gcgggtcttc ctcgagccct cgtcggatcc
    20401 ggtggagcag cccctcgcgc cgggagaggc ggtgctcacg gtcgagcgct tcgcgttgac
    20461 ggccaacaac atcacctacg gggtgatggg cgaggcgctg ggctactggc gctgctttcc
    20521 caccgctccc gactggcggg gccggattcc cgcctggggc tacgcgcggg tctcgcgctc
    20581 ctcctccccg gaggcccccg tgggactgag gttcttcggc ctcgtgccca tgtcgacgca
    20641 cttcgtggcc cggctgcagc gcaccggcag tggctatctg gatgcggcga cgcaccgggc
    20701 gggcctgtcg cctttctaca atcgctacac gcgcgtcgag gtggacgagt ccttcgacaa
    20761 tcatcgcgcg ctgctgcggc cgctcttcac gacctcgttc ctgctggatg acatgctgta
    20821 cgaggcggag catgccggga cgcggaccgt catcctgtcg agcgcctcga gcaagaccgc
    20881 catgggcctg gcgtggttgc tctcgcggca cgggatgaag gtggtgggcc tcacgtcgcg
    20941 caagaacctc gccctgctcg gcggcctggg cctgtaccag cagctcgtcc cctatgacgc
    21001 gatggccggg ctgtgggtcg agacgcccgc ggtcttcgtc gacttcgccg gggacccggc
    21061 cgtggtgcgg ggcatccatc ggcagctcaa ggacgggctg cgccagagca ccctcgtggg
    21121 aggcacgcat cagcggacgc ctcccccagc gaagggcgac cccctgccgg ggcccacgcc
    21181 caccttcttc ttcgcaccgg atcggctgcg caagcgggtg acggactggg gactggagac
    21241 cttcgagtcc cggctggcgg aggccatgaa ggccttcgtg gccgccagct cctggctgcg
    21301 gatcgaacac catcggggcc ccgaggcact gaaggccgtc tatcgcgacg tcgtgacggg
    21361 ccaggcccgt cccgaggccg ggcacatcat ctggccggac cccgcctccc ggtgaaacgc
    21421 gcacgcgaga aggagacctt ctccgcgtca gcacgtctga ggagacatcc ggcccggggt
    21481 gggtagcgcc gcccccgcgt gggcgtctac acgccccggc catgaaccca gctcctctct
    21541 ccaggctcct gtccgccacg gacgcgccgc gccaggcgct cctgcggcat cccgtgtacg
    21601 agcggctctc ggacttgaac gccctgcaca ccttcatggg cgcccacgtg ttcgccgtgt
    21661 gggacttcat gagcctgctc aagacgctcc agcgccagct cacgtgtgtg gaggttccct
    21721 gggcgccccc ggcggacatc gagtgcgcgc ggatgatcaa cgagatcgtc ctgggcgagg
    21781 agacggacga ggtccggccc ggggtgtacc agagccactt cgagctgtac cgggaggcca
    21841 tgcgcgaggt gggcgcggac gaggacgcgg tgctgcgctt cgtcgagtcc ctgcgctccg
    21901 gtcactcgct ggagagggcg ttggagcacg cgcccgtggc ggcacgcgcc ttcgtgagtc
    21961 acaccctggc gacgacccgg ctgcgccccc atcaggtggc cgcggccttc ctcctcggcc
    22021 gggagtccct gctgcccgcg gtcttcgagc gcatcctcac ggccgtgaag ccgctgggca
    22081 ccgggtgcgc ctcgctgcgg ctgtacctgg agcggcacat ccagctcgac ggcgaggagc
    22141 atggcgtccg ggcggagcag ctcctgtgcc ggctgtgcgg agaggacccc gagcggtgga
    22201 gggaagcacg ggaggcggcc ctgtccgccc tgcgcgcccg ggcggagctg tgggacggcg
    22261 tgttgggagc cctggacgcc acggtgccct cgagaggccg gatgaacgtg gggtgagccc
    22321 ggggccctcc gggtctctgg aagtggggcg gggtggaggt tacaaagccc cgatggacgc
    22381 ccgcatcgtc gagttcgccg aggtcctccg ccagaacggt gtgcgggtga gcacgtccga
    22441 ggtagcggat gcgacccggg ccgccgcgga ggtggggctc caggacaagg ccgtcttccg
    22501 cgccgtcttg cgcaccacgt tgatcaagcg ggagcaggac ggggacgtgt tccagcgtgc
    22561 cttcgacttc ttcttctcgg ggacgtccag gcccttcgag gcgctcgagc cgtcgctcgc
    22621 cgggcggctc caggagcagg ggctgctcga gggcgagtcg ttgaggacgg tgctcgacga
    22681 gctgcaccgg cgccttcccg gaatgtcccc gctctcccag gcggtgctcg aggggaaccc
    22741 ggcggtgctg gcgcggctgt tccgcacggc ccagctccag ttggacttct cccggatgag
    22801 gggtccgctg cagatgggct tcttctcgcg gcggctgatg gtggcggcgg ggttggagag
    22861 ggcccgctcg gagctccagt ccttcgcgga cacgctgcgc gagcagggcc tggggccgga
    22921 cggcgtggag atcgtctcgc gccacatgga cggggccctg cgccaggtgg aggacgcggc
    22981 gcggcgcgag gtgaagcgcc aggcggacgc gcgcatcggc aagccctcgg gcggactgga
    23041 ggacaagccg ttgcaccggc tcagccaggc cgaggtgaag cagatgcagg cggcggtccg
    23101 cgccctggcg gagaagctca aggcccggct catgcgcaag cggcgctcgc ggcgcgaggg
    23161 cacgctccac gtgagccgca ccctgcgcca caacctgccg tggggtgggg tgccgatggt
    23221 gccctggttc c
//
