LOCUS       NZ_CP022098            10846 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5857472
            Orig. end                         :: 5868318
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10846
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="28"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10846
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10846
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5846](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5846)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(295..3366)
                     /locus_tag="CYFUS_RS23835"
                     /old_locus_tag="CYFUS_004707"
     CDS             complement(295..3366)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014081.4"
                     /locus_tag="CYFUS_RS23835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004707"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_157758613.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.7e-08, bitscore:
                     33.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAREVEQDILMHPPRSHRSMFAISQSLLAISAFFLLTGAKGQDPG
                     GASSPVAPSNGVYRGATLAAPSFTGSPAAGRINGLLDPVREFTLTLTEGTNMAAAPSPD
                     ATRIALALQGALYVVPISGGEARRISTWSMEVTHAVWSPDGSRIAFQNYDTEGNYHIWT
                     IAPDGSNATRVTTGPFDDREPSWSADGSRLIFSSDRSGDMQYKIWSIGIADGQYQQLTT
                     GAGAESHPALSPDGTKLLLVENGGVVLVDLVTGARTSRGAGSAPAWTPDGSGVISQGGG
                     SWSVNGVPVNAASEDLFPFPARFLPDGRFLYTGDGKIRLRTTTGESVSDVPFSAQIALR
                     RPVFTPKAQHRLDDLDWRTVKGISAPILSPNGEKVAFVALNDIWVLSINGDGQPVRLTD
                     TRDYKASPGWSPDGSFVYFSTDRDSGGVLAVDKVELSSRKRSRLVLLTGISMAYPSLSP
                     SGRQLAYWTGGGRVEVYDLAARTSTVIVNPSLGTGVSRPSWSSDERLLAVCDAERVNNR
                     FREGYNKLRIIDINNKTAVFHAVGPTPASISERNEAGPVWSPDGRKMAFIMDSLLYVMP
                     VNLDGSPSGPAAQLTTYAADMPSWGPDSNTLLFMASGHLRTLNLSSRATHDIALDMQYK
                     QATPAGITIIHAGGLWDGVTATLQYNKDIIIDKNRIIAIEPHGTRSADTANKYIDASGL
                     TVMPGLWDSHVHPLDVFNNQAYGLAWAEMLAWGVTSTLSMGGDLYQSVEVREALDAGVL
                     VGPRAFIAPPLYDGSRVFYPSARAVRNEQVAELEMSRMKPFDVDLLKAYVRAPIPVMEI
                     VARTAHELGLPSFSHFLSPGIQTGLLGTSHLSATERLGYSWSISTRYQDVRELRTHGLF
                     NMVATTGSSQNDPVVRGGGLVTMGTDFPLAPAGSGLHTIMREEATTLGAFEVLKTVTIN
                     GALNARVGNELGSIEPGKLADLIAIRGNPLENVANVGNIVYVVKNGLATTPEEIRARFT
                     TTRALTQRAKALDAFAKACRKEPEWCHPPAMAGH"
     misc_feature    complement(3283..3285)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3581..4222)
                     /locus_tag="CYFUS_RS23840"
                     /old_locus_tag="CYFUS_004709"
     CDS             complement(3581..4222)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620704.1"
                     /locus_tag="CYFUS_RS23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004709"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_095987316.1"
                     /transl_table=11
                     /translation="MNPIPLPHRFGGWKLFLMLAALLMGAAGAAYLIGPDAVEGSRRVI
                     RVTARTSFVLFLAAFTASSFASLLPGPFTQALLRERRIVGLSFAFSHLLHAIAIYAFGQ
                     LNPEFWPGRSTLTNLPGTIGYVAILLLAVTSHRGLARRMGSTAWRRLHVTGMWVIAAVF
                     TYSYFKRVPMNYWYAVPSALLFTAVVVRLIARRAQALRRGTRSPLAPTAA"
     gene            complement(4237..5004)
                     /locus_tag="CYFUS_RS23845"
                     /old_locus_tag="CYFUS_004710"
     CDS             complement(4237..5004)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="CYFUS_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004710"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_095987317.1"
                     /transl_table=11
                     /translation="MTATLRALQLAWAAHVRDPSRPPPPGVAPERLALYRALCVNGVES
                     LLTGSFPRLYMLLGEAGWRRAIEDFYRRHRCDTPLFPQVAGEFAAWLAEPDTALPPWAA
                     ELADYEWSRHALLFAEATAAPVPVAGLALDVPLALSPLAHVRGYHWPVHMESALPPDTD
                     APPAAPTLLLLRRDADHVLRTDLLSPFAYRLLQAIATGADSARAHLSALAHESGTAAAD
                     MLAHGQVLLAELWSARIVVTASAPADADPFHPE"
     gene            complement(5001..5846)
                     /locus_tag="CYFUS_RS23850"
                     /old_locus_tag="CYFUS_004711"
     CDS             complement(5001..5846)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620706.1"
                     /locus_tag="CYFUS_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004711"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_095987318.1"
                     /sec_met_domain="DUF692 (E-value: 1.2e-118, bitscore:
                     394.5, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTLHTASAGLGLRRGMLTDLLALTPDAVDFLECAPDNWIGVGG
                     SFGKVLDELSTRFPITCHGLSLSLGGTDPLDRRLLVRTREFIDRHAVTLYSEHLSYCAA
                     DGQLYDLLPLPFTEEAVRHVAARISQVQDMLGRRIAVENISYYAVPTPAMSESEFINAV
                     LAEADCDLLLDVNNVFVNACNHGYDAFGFLDQLPPDRVASYHVAGHIDRADGLKIDTHG
                     AAVRGLVWTLLDHAYARFGVRPTLLERDFNFPPIAELLAEVARIRDTQATHLPRPELVP
                     "
     gene            complement(5901..6401)
                     /locus_tag="CYFUS_RS23855"
                     /old_locus_tag="CYFUS_004712"
     CDS             complement(5901..6401)
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620707.1"
                     /locus_tag="CYFUS_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004712"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_095987319.1"
                     /transl_table=11
                     /translation="MSHSESRNRKPLVGAIGVALAGGVLLSTQALAMQPLTLGAMAVAS
                     AGEGGCGEAGCGASHTTAKTGTTAKTGTTAAPAAEGKCGEGKCGEGKCGDASFARTDSN
                     HDGKVSRAEFLAVAAKRAADFDRIDSDHDGYISEQEAHDFLRAAYEANGKTLPKGRFAN
                     IVD"
     gene            6766..7563
                     /locus_tag="CYFUS_RS23860"
                     /old_locus_tag="CYFUS_004713"
     CDS             6766..7563
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620708.1"
                     /locus_tag="CYFUS_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004713"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_095987320.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.6e-19, bitscore:
                     68.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKTMLAALVATALIPVAACSGPVPTDPAAPTVILVHGAFADGS
                     SWNKIIPRLEARGVPALAVQNPLTSLQDDVAATRRAIAAAPGKVVLVGHSWGGTVITEA
                     GDDDKVVALVYVSAFAPDAGENSAQQGEPFPTAPGLTRLQDRDGFLWLPAEAVAEDFAQ
                     DLDPATARLIYSTQGPLKASALSEPVARAAWKHKPNWYVLSREDRMLAPQLQSATAQRI
                     GARLHSIQASHVSMLSHPGEVADVILEAAGVKPADPSPAKVGG"
     gene            7565..8257
                     /locus_tag="CYFUS_RS23865"
                     /old_locus_tag="CYFUS_004714"
     CDS             7565..8257
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014713.4"
                     /locus_tag="CYFUS_RS23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004714"
                     /product="cytochrome c biogenesis CcdA family protein"
                     /protein_id="WP_095987321.1"
                     /transl_table=11
                     /translation="MWAFVLAALAGVATILSPCVLPMLPIVLARGAGGDRREPLLIVVG
                     FVASFAAGGIAIGALAASSGQFEAGVRVAALVVLLLAGLACVWPTPFERLQQRWLAGSR
                     LFAWQPRAAGAGGALLVGVSLGIAWTPCAGPVLASVLALAASAQATARASALLGVYALG
                     AVTPLLALIYGGRWASARLRPLQRHTAWVRRGFGVCAVAMALLQLWQLDAALTARLLPW
                     LPSISTGL"
     gene            8260..8799
                     /locus_tag="CYFUS_RS23870"
                     /old_locus_tag="CYFUS_004715"
     CDS             8260..8799
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620710.1"
                     /locus_tag="CYFUS_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004715"
                     /product="thioredoxin family protein"
                     /protein_id="WP_095987322.1"
                     /transl_table=11
                     /translation="MPTYLRAFLIVAIVTVFTVLAWSSSRADEARPATLTTAPDFSGGG
                     EWINSPPLSMSRLRGKVVLVEFWTYSCINCLRVAPHVSQWHARYADQGLVVVGVHTPEY
                     GYERVNANVHEAVQRLGIHYPVVQDNGYRIWNAYGNQYWPALYLIDREGRVVYRHFGEG
                     AYDRTEAQIQALLAAR"
     gene            8815..9606
                     /locus_tag="CYFUS_RS23875"
                     /old_locus_tag="CYFUS_004716"
     CDS             8815..9606
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620711.1"
                     /locus_tag="CYFUS_RS23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_004716"
                     /product="response regulator"
                     /protein_id="WP_269770258.1"
                     /transl_table=11
                     /translation="MAASVAAAVAILPTDDTMAHTDHILIVDDDREIRRMVGEYLQRNG
                     LRTTLAADGREMRAALDTSDVDLIVLDVMMPGEDGLSLCRNLRAGKHRNVPVVMLTARD
                     EETDRIVGLEMGADDYVVKPFSARELLARINAVIRRSRMMPPNLQVTEAGRLIGFGQWR
                     LDTTARHLLDEDGTAYPLSGAEFRLLRVFLDHPQRVLSRDQLLNLTRGRDAELFDRSID
                     LLVSRLRQRLRDDAREQAYIKTVRSEGYVFCQPVVLLGENT"
     misc_feature    complement(10171..10185)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    10560..10573
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
ORIGIN
        1 cgaagatgtc gccgtggggt tcctgctgct gctccttcga cgtcaaggga tgcgatctcg
       61 acatggaagg agtaccacta gcggcagaaa ccagttccca ccaccccgaa atgcaggttg
      121 agcaggggca ttccgccgct tggttggctg ctgaaaaaga gacgggaccc ctgccgctcc
      181 ccccaacatt cgcggttcga tcccacagcc ttacccatct ggtagtgggc cgtctggggg
      241 tcgaaggcct ttttcagcac ccgggcgggc tcggggaacg gaaacgccgg acgctcaatg
      301 gccagccatg gctggcggat ggcaccactc cggctccttc ctgcaggcct tggcgaacgc
      361 atcgagcgcc ttcgctcgct gcgtcaatgc cctggtcgtg gtgaatcgcg ccctgatctc
      421 ctctggcgtg gtcgccagac cgttcttgac cacgtacacg atgttcccaa cattcgctac
      481 gttctcgaga ggattgccgc ggatggcgat cagatcggcg agcttgccgg gctcgatgct
      541 tcccaactcg ttgccgacgc gcgcgttgag cgcaccgttg atggtcacgg tcttcagcac
      601 ctcgaaagcg cccagtgtcg tggcctcctc tcgcatgatg gtgtgcagtc cgctgcccgc
      661 gggcgccaac gggaaatccg tacccatcgt gaccagacct ccgccgcgga caaccggatc
      721 gttctgcgag gagcccgtgg tggcaaccat gttgaacagt ccgtgggtgc gaagctcgcg
      781 gacgtcctgg tagcgagtgg atatcgacca cgaatagccc agccgctcag tcgcggacag
      841 gtgcgacgtg cccagcaggc cggtctggat tcccggagag aggaagtgcg aaaagctcgg
      901 cagaccgagt tcgtgggccg tacgtgcgac gatctccatc actggaatgg gagcccgcac
      961 gtaggccttg agcagatcga cgtcgaaggg cttcatcctg ctcatctcga gctcggcgac
     1021 ctgctcgttg cgcacggctc tggcggacgg gtagaaaact cgcgagccat cgtagagcgg
     1081 cggtgcgatg aacgcccgag ggcccaccag gactccagca tccagcgcct cgcggacctc
     1141 gacgctctga tacagatctc cgcccatgga aagcgtcgac gtcacccccc aggcgagcat
     1201 ctcggcccag gcgagtccgt aggcctgatt gttgaagacg tcgagaggat ggacatgtga
     1261 atcccagagc cccggcatga cggtcaaacc ggacgcatcg atgtacttgt tcgcggtgtc
     1321 cgcggatctc gttccgtgcg gctcgatcgc gatgatgcga ttcttgtcga tgatgatgtc
     1381 cttgttgtac tggagggtcg cggtcacgcc gtcccagaga ccgcccgcgt ggatgatggt
     1441 gatgccggcg ggcgtggcct gcttgtactg catgtcgaga gcgatgtcgt gcgtggccct
     1501 gctcgagagg ttgagcgtgc gcaggtgacc gctcgccatg aagaggagcg tattggaatc
     1561 cggtccccac gagggcatgt ccgctgcgta tgtggtcaac tgagcggcgg gaccgctcgg
     1621 cgagccatca agattgaccg gcatgacata cagcaacgaa tccatgatga acgccatctt
     1681 gcgtccatcg ggcgaccaca cggggcctgc ttcattccgc tcggaaatgc tcgcgggcgt
     1741 tggcccgacc gcgtgaaaca ccgccgtctt gttgttgatg tcgatgatcc tgagcttgtt
     1801 gtatccctcc ctgaaccggt tgttcacccg ctcggcgtca cagacagcga gcagccgctc
     1861 atcggatgac cacgaagggc ggctgacacc cgttccgagc gaaggattca cgatgacggt
     1921 gctcgtgcgt gccgcgagat catagacctc cacccggccc cccccggtcc aataggcgag
     1981 ctgccggccg ctgggcgaaa gcgagggata cgccatcgag atgccggtga ggaggacaag
     2041 ccggctgcgc ttgcgagagg acaactccac cttgtcgacg gcgagaacac cgccactatc
     2101 cctgtccgtg gagaagtaga cgaagctgcc gtcgggcgac catccaggac tggctttgta
     2161 gtccctcgtg tcggtcagcc ggaccggctg gccgtcgccg ttgatgctca gcacccagat
     2221 gtcgttgagc gcgacgaagg cgaccttctc cccgttcgga gacaggatcg gagctgaaat
     2281 gcccttcacg gtacgccagt caagatcgtc gaggcgatgc tgcgccttcg gcgtgaaaac
     2341 aggccggcgc agcgcgatct gggcgctgaa gggaacatcg ctgacactct cacccgtggt
     2401 tgtacggagc ctgatcttgc cgtcgccggt gtacaagaag cggccgtccg gcagaaagcg
     2461 cgccgggaac ggaaacaggt cctcgctggc ggcattcacg gggactccgt tcacgctcca
     2521 agagccgcca ccctgcgaga tcacgccgct tccatcgggt gtccacgcgg gcgcgctgcc
     2581 agccccgcga gaggtgcgtg cacccgtgac gaggtccacc aggacgacgc caccattctc
     2641 gacgagcagc agcttcgtgc catcagggct cagcgcggga tggctttcgg ctcccgctcc
     2701 cgtggtcagc tgctgatact gaccgtcggc aatgccgatg ctccagatct tgtattgcat
     2761 gtcgccgctg cggtcagaag aaaagatgag gcgcgagccg tcggcgctcc aactcggctc
     2821 gcgatcatcg aacgggccag tcgtgacgcg agtggcattc gagccatcgg gagcgatcgt
     2881 ccagatgtga taattgcctt cggtgtcgta gttctggaac gcgatgcgcg agccgtcagg
     2941 cgaccatacc gcgtgcgtga cttccatgct ccaggtggaa attcgccttg cctctcctcc
     3001 ggagatcggc accacgtaga gcgcgccctg cagcgccagc gcgatccgcg tcgcgtctgg
     3061 agacggcgct gccgccatgt tggtaccttc cgtgagagtg agcgtgaact ctctgacggg
     3121 atcgagcaga ccattgatcc tgcccgccgc cggcgagccc gtaaacgatg gcgcggccag
     3181 cgtcgctccc cgatagacgc cgttcgaggg ggcaacgggg gatgatgcgc cgcccgggtc
     3241 ctggcccttg gcgcccgtga gaaggaagaa tgccgaaatg gctaacagac tttgagaaat
     3301 ggcgaacatg cttcgatggg aacgcggagg atgcatgagg atgtcctgtt ctacttcgcg
     3361 cgccacgggg cgcacgtctg aagcctaaat aagatcagcg cggtccgagc gccacgatct
     3421 tcttgccaac atactgctgg cgattgtgat tcacgtcgtc ggcgatgaag atggttgttg
     3481 ccgccgccgc gggtgcggag ctcgtggtca tgcggagcct ttcctgtctt tgtggactcg
     3541 acgcggcggc gggtgcggcg ctgggcattc ctccggcacg tcaagcggcg gtcggagcca
     3601 agggagaccg ggtgccgcgc cggagggcct gggcacgcct ggcgatcagc cgcaccacca
     3661 ccgcggtgaa cagcagcgcc gaaggcacgg cgtaccagta gttcatcggc acgcgcttga
     3721 agtacgaata ggtgaacacc gccgcgatca cccacatgcc ggtgacgtgc agccgtcgcc
     3781 aggcggtcga gcccatgcgc cgggcaaggc cgcgatgcga ggtcaccgcc agcagcagga
     3841 tggccacgta gccgatcgtg ccgggcaggt tggtcaaggt ggagcggccg ggccagaact
     3901 cgggattgag ctggccgaag gcgtagatcg cgatcgcgtg cagcaggtgc gagaacgcga
     3961 acgacaggcc gacgattcga cgctcgcgca gcaacgcctg ggtgaacggg ccgggcagca
     4021 gcgaggcgaa cgaggacgcg gtgaacgcgg ccaggaacag aacgaaggag gtacgggcgg
     4081 tgacgcggat cacgcggcgg ctgccttcca ctgcgtcggg gccgatcagg taggcggcgc
     4141 ccgcggcacc catcagcagc gcggccagca tcaggaacaa tttccagccg ccgaagcggt
     4201 ggggcagggg gatcgggttc atggcgagga ctccattcat tcggggtgga aggggtcggc
     4261 gtcggcggga gcactggccg tcacgacgat gcgcgcggac cacagctcgg cgagcagcac
     4321 ctgcccgtgt gccagcatgt cggccgccgc cgtgccgctc tcgtgtgcca gcgcggagag
     4381 atgtgcccgc gcgctgtcgg ctccggtggc gatggcctgc aacaggcgat aggcgaacgg
     4441 cgagaggagg tcggtgcgca gcacatggtc cgcgtcgcgc cgcagcaaca gcagggtggg
     4501 cgcggccggc ggtgcgtcgg tgtcgggagg cagtgccgac tccatatgca ccggccagtg
     4561 atagccgcgc acgtgggcca gtggcgacag cgccagcggc acgtccagag ccagcccggc
     4621 cacggggacg ggtgcggcgg tggcctcggc gaacagcagc gcatgccggc tccattcgta
     4681 gtcggccagt tccgctgccc acggcggtag cgccgtgtcg ggctcggcca gccacgcggc
     4741 gaactcgccg gcgacctgcg ggaacagcgg cgtatcgcag cgatgccggc ggtagaagtc
     4801 ctcgatggcg cgacgccacc cggcctcgcc caacagcatg tacaggcgcg ggaagctgcc
     4861 ggtgagcagc gactcgacgc cgttcacgca cagggcgcgg tatagcgcca gccgttccgg
     4921 ggccacgccc ggtggcggcg gtcgcgaggg atcgcgcaca tgcgccgccc aggccagttg
     4981 cagcgcgcgc agcgtggcgg tcatggcacg agctccggcc gtggcaggtg cgtggcctgt
     5041 gtgtcgcgga tgcgtgccac ctcggccagc agctcggcga tcggcgggaa attgaagtcg
     5101 cgttcgagca gggtcgggcg cacaccgaag cgtgcgtagg catggtcgag cagggtccac
     5161 accaggcccc tcaccgcggc gccgtgggta tcgatcttga ggccgtcggc ccggtcgatg
     5221 tggccggcga cgtggtacga ggccacgcga tcgggcggca gctggtcgag gaatccgaag
     5281 gcgtcgtagc cgtggttgca ggcgttgacg aagacgttgt tcacgtccag cagcaggtcg
     5341 cagtcggcct cggccagcac cgcgttgatg aattcgctct cgctcatcgc cggcgtgggc
     5401 accgcgtagt aggagatgtt ctccaccgcg atgcgccggc ccagcatgtc ctgcacctgc
     5461 gagatgcgcg cggcgacatg gcgcacggct tcctcggtga acggcagcgg cagcaggtcg
     5521 tagagctggc cgtcggccgc gcaatagctc aggtgctcgc tgtagagcgt gaccgcgtgg
     5581 cggtcgatga attcgcgcgt gcgcaccagc agccggcggt ccagcgggtc ggtgccgccc
     5641 agcgacagcg acaggccatg gcaggtgatc ggaaagcgcg tggacagttc gtccagcacc
     5701 tttccgaagg aaccgcccac gccgatccag ttgtccggcg cgcattccag gaaatcgacc
     5761 gcatctggcg tcagggcgag cagatcggtg agcatgccgc ggcgcaggcc gagcccggcc
     5821 gaggcggtgt gcagggtggg attcatctcg ttgctccgcc ggggcgccgc cgcgcggagg
     5881 cggcggcgcg gggtgtttgt tcagtcgacg atgttggcga agcggccctt cggcagggtc
     5941 ttgccgttcg cctcgtaggc cgcgcgcagg aagtcgtgcg cctcctgctc gctgatgtag
     6001 ccgtcgtggt cactgtcgat gcggtcgaag tcggccgcgc gcttggcggc cacggcgagg
     6061 aactccgcgc gcgagacctt gccgtcgtgg ttgctgtcgg tgcgggcgaa ggaggcatcg
     6121 ccgcacttgc cttcgccgca cttgccttcg ccacacttgc cctcggcggc cggcgctgcg
     6181 gtggtgcccg tcttggcggt agtgcccgtc ttggcggtgg tgtggctggc gccgcatccg
     6241 gcttcgccac acccgccttc gccagcgctg gccacggcca tcgcgccgag ggtcagtggt
     6301 tgcatcgcca gcgcctgcgt gctgagcagc acgccgccgg cgagggcgac gccgatcgcg
     6361 ccgacgaggg gtttgcgatt gcgggattcg gaatgggaca tggtaggttt tcctgcggga
     6421 cgttgcgttg acatggacgg ctcctcgcca tggcggcgtt gaatgggatg gtggctattg
     6481 aaagggcgcg aggtatccgc accgtgtcgg gtaggccgga gttttgtcag cgcttgtgtc
     6541 gcggacggcg gtcgatacat ttcgatacga aatgcccggc ggtgggcgac aggcacgggg
     6601 cgaggtcacg cgaccgcgca ccggcgtggc tggcgcgggc gttgtgtgtc gaaacgtagc
     6661 gccgcgccac gccgacacct tgtgtgacaa gaagccgtcc gcgcggaaac agcggcgata
     6721 cagtcgtggc ttgcaatgag cgctccttcc acaggagtgc tctcaatgat tcgcaagacg
     6781 atgctggccg cgctggtggc caccgccctg attccggtcg ccgcgtgctc gggtccggtg
     6841 cctactgatc cggccgcgcc cacggtgatc ctggttcatg gtgccttcgc cgacggttcg
     6901 agctggaaca agatcatccc acgcctggag gccagggggg tgcccgcctt ggcggtgcag
     6961 aacccgctga cctcgctgca ggacgacgtg gccgccacgc gtcgcgccat cgccgccgcg
     7021 ccgggcaagg tggtgttggt cggccattcc tggggcggca cggtcatcac cgaggccggc
     7081 gacgacgaca aggtggtcgc gctggtgtac gtgtccgcgt tcgcgcccga tgctggcgag
     7141 aactcggccc agcagggcga gcctttcccg accgcgccgg ggctgacgcg actgcaggat
     7201 cgcgacggct ttctgtggct gccggccgag gcggtggccg aggatttcgc gcaggacctc
     7261 gatccagcca ccgcgcgcct gatctacagc acccagggcc cgctgaaggc cagcgcgctg
     7321 tccgagccgg tcgcgcgggc ggcgtggaag cacaagccca actggtacgt gctcagccgc
     7381 gaggatcgca tgctcgcccc gcagttgcag tccgccaccg cgcagcgcat cggcgcgcga
     7441 ctgcattcga tccaggccag ccatgtctcg atgctgtccc atccgggcga ggtcgccgac
     7501 gtcatcctcg aggccgctgg ggtgaagccg gccgatccgt cgccggccaa ggtgggtggc
     7561 tgacatgtgg gctttcgtcc tggccgcgct ggctggcgtg gccaccatcc tctcgccgtg
     7621 cgtgctgccg atgctgccca tcgtgctggc gcgcggggcc ggcggcgacc gccgcgaacc
     7681 gctgctgatc gtcgtcggct tcgtcgcctc cttcgctgcc ggcggcatcg ccatcggcgc
     7741 gctggcggcg tcctccggcc agttcgaggc aggcgtgcgc gtggccgcgc tcgtggtgct
     7801 gctgctggcc gggctggcct gtgtgtggcc aacgccgttc gaacggttgc agcagcgctg
     7861 gctggccggc tcgcgcctgt tcgcctggca accgcgggcg gccggcgcgg gcggcgcgct
     7921 gctggtcgga gtctcgctcg gcatcgcctg gacgccatgc gccgggccgg tgctggcctc
     7981 ggtgctggcg ctggccgcca gcgcccaggc caccgcgcgc gccagcgccc tgctcggcgt
     8041 gtacgcgctc ggcgcggtca ctccgctgct ggccctgatc tacggcggtc gctgggccag
     8101 tgcccggctg cgcccgctgc aacgccacac cgcctgggtg cggcgcggct tcggcgtctg
     8161 cgccgtggcc atggccctgc tccagttgtg gcagctcgat gccgcgctca ccgcgcgact
     8221 gctgccatgg ctgccctcca tctccaccgg actgtgaaca tgcctaccta cctccgtgct
     8281 tttctcatcg tcgccatcgt caccgtgttc accgtgctgg cctggtcctc ctcccgcgcg
     8341 gacgaggcgc ggccggccac gctcaccacc gcgccggact tcagtggcgg cggcgagtgg
     8401 atcaacagcc cgccgctgag catgtcgcga ctgcgcggca aggtcgtgct ggtcgagttc
     8461 tggacctact cgtgcatcaa ctgcctgcgc gtggcgcctc acgtctcgca atggcacgcg
     8521 cgctacgccg accagggcct ggtcgtggtc ggtgtgcaca cgcccgaata cggctacgag
     8581 cgcgtgaacg ccaacgtgca cgaggcggtg cagcgcctgg gcatccacta tccggtggtg
     8641 caggacaacg gctaccggat ctggaacgcc tacggcaacc agtactggcc cgcgctctac
     8701 ctgatcgaca gagagggcag ggtagtgtac cgccatttcg gcgagggcgc ctacgaccgc
     8761 accgaggcgc agatacaggc cctgctggcc gcgcgctgac actggcgggt taacatggcg
     8821 gcgtccgtgg cggcggccgt cgccatcctt cccacggacg acaccatggc ccatacagac
     8881 cacatcctca tcgtcgacga cgaccgcgag atccgtcgca tggtcggcga gtacctgcag
     8941 cgcaacggct tgcgcaccac gctcgccgcc gatggccgcg agatgcgcgc ggcgttggac
     9001 accagcgacg tcgacctgat cgtgctcgac gtgatgatgc cgggcgagga cggtctgtcc
     9061 ctgtgccgca acctgcgcgc cggcaagcac cgcaacgtgc cggtggtgat gctcaccgcg
     9121 cgcgacgagg agaccgatcg catcgtcggc ctggagatgg gtgcggacga ctacgtggtc
     9181 aagccgttct ccgcgcgcga gctgctggcg cgcatcaacg cggtgatccg gcgctcgcgc
     9241 atgatgccgc ccaacctgca ggtcaccgag gccggccggc tgatcggctt cggccagtgg
     9301 cggctggaca ccaccgcgcg ccacctgctc gacgaggacg gcaccgccta tccgctcagc
     9361 ggcgcggagt tccgtctgct gcgcgtgttc ctcgaccacc cgcagcgcgt gctcagccgc
     9421 gaccaactgc tcaacctcac ccggggccgc gacgccgagc tgttcgaccg ctccatcgac
     9481 ctgctcgtca gccgcctgcg ccagcgcctg cgcgacgacg cgcgcgagca ggcctacatc
     9541 aagaccgtgc gcagcgaggg ctacgtgttc tgccagcccg tggtcctgct cggcgagaac
     9601 acatgaacgc caccccgagc accggctggc gacgcctgct gccacgcact ctcggcgcgc
     9661 gcctgaccct gatcctgttc accggcttgc tgctcgcgca cgcgctgtcc ttcgcgctgc
     9721 tgttctccga gcgctacgtg gccgcgcgtt cgatgatgct caccaacctg gatcaggacg
     9781 tggccgtcag cgtggccctg ctcgaacgcc tgagcccggc cgagcgcgcg cgatgggcgc
     9841 cgcgcctgga gcggcgcacc taccgctacc tgctcggccc cgcgcggccc ggtgtgccgc
     9901 tgaccagtga ccgcgcgcgc gaggtcaccg ccctgatcga ccgcagcctg aaccatcgct
     9961 acgccctgcg ggcgcgcacg gtgtccacct cgccggagcg cttcgaggtg gaactcaccc
    10021 tggccgatgg ccagccgttg accatcgagg tcacaccctc ggtgatgccg atcgcgcgct
    10081 ggttgccggt ggtgctggcg gcgcagctgg cgctgctgct gttgtgcgcg tggttggcgg
    10141 tgcgcctggc gacgcggccg ctggtgcaac tggccgacgc ggtcgagcgg ctggacccgg
    10201 cccgcgcgca tccgccgctg ccgcaggaag ggccggtgga agtggtcaag gccgctaccg
    10261 cgttcaatgc gatgcaggcg cgcatcggcc actatctcgc ggagcggttg cagatcctgg
    10321 ccgcgatctc gcacgatctg cagactccga tcacgcgcat gaagctgcgc ctggaagcga
    10381 tggaggaggg cgccgagcgc gatcgcctga ttggcgacct ggagcagttg cagcagttgg
    10441 tgcgcgaggg catcgcctac gcgcgcagca cccatggagc caccggcccg gaggtgcggc
    10501 tggacctgca cgcattgctc gacagcgtgg tgtgcgacta ccaggacacg ggcaagccgg
    10561 tcacgctggg cgaatgcgcg cgcgtttcgt tgagcacgcg gccgccgaca ttgcggcgcg
    10621 tcgtcgagaa cctgatcgac aacgcggtga agtacggcgg cggcgccgag gtcggcatgc
    10681 gccggctcga cgacgggcgc gtggccgtgg acgtgtgcga ccgcggcccg ggcattcccg
    10741 aacaggagat gcaggcggtg ctgcaaccgt tctaccggct ggaaagctcg cgcaaccgcg
    10801 ataccggcgg caccggactg gggctggcca tcgctcagca actggc
//
