LOCUS       NZ_CP022098            22170 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3769233
            Orig. end                         :: 3791403
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22170
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="proteusin"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(PoyD or TIGR03793)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22170
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PoyD or TIGR03793)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="proteusin"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22170
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12170](+)"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
     gene            801..2666
                     /locus_tag="CYFUS_RS15550"
                     /old_locus_tag="CYFUS_003076"
     CDS             801..2666
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002623368.1"
                     /locus_tag="CYFUS_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003076"
                     /product="ATP-binding protein"
                     /protein_id="WP_232537580.1"
                     /transl_table=11
                     /translation="MLRSWLWEQLDSMLSESLRRAEPSELIRYRIMVGAACFFSLINGV
                     FLLRSFSQGNFPYAAILASFGYVGTLVLARRGRTPIAPAMVLLATLTLGLVITTFTSRK
                     PTGGDHAVNMLLPVLAVYLVGPRLGLSITLALFVTLGLIHPYYRSQVGIDPSTLTLSGL
                     WFSHVFAGISSLGVWALSSLHSTARDAAQATIERTVRELRDSQSKLNSVFESTDDIVVS
                     IDSQARLLTANSAARFIYEHRGGIVLEPGMPLFQHEAPEIRKAWDARLVQVLQGQRLRF
                     EQTYQDQQGLLVLDTSVHPIVEEGGRVVGMTIFGRDVTARRQAEARLGEMHRTLVDVSR
                     QAGMAEVATGVLHNVGNTLNSVNISTSLVIDQLRKSRVTSLARVATLLREHLADLPAFF
                     ARDAQGQQLPPFLIALSAQLQEERAAMLREMYSLGESVEHINSIVSMQQKHARAAGAVE
                     HVAVPQLIDEALRLHAVSFDRQRIQVECDYAEVPPIFVDRHKLLQILINLVSNARHALV
                     ASPKTDKRMGIHVRRAPDPGHLHIEVTDNGVGIAPENLGRMFSQGFTTKKMGHGFGLHI
                     SALAAAEMKGRLSCSSPGLEQGATFLLDLPMQTEVPPVQEDAEPS"
     gene            complement(2670..3326)
                     /locus_tag="CYFUS_RS15555"
                     /old_locus_tag="CYFUS_003077"
     CDS             complement(2670..3326)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.4"
                     /locus_tag="CYFUS_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003077"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_095985939.1"
                     /transl_table=11
                     /translation="MTTKRPPDEVATAYDVWSEVYDTQANATRDLDAAILHDQEPSLFR
                     GDVLEIGCGTGKNTEWLAPQARSLLALDASEKMLNRARERPGVQHVQFFLQDLRERWPA
                     AEASRDTVTCNLVLEHIEELSFVFSEARRVLRPGGALFVCELHPFRQLQGKQAYFVDPD
                     TGALQNVRSHLHDVSEYLNAAADAGFVLVRARDCRDPGAPRSDVPRLLALLWRRA"
     cand_cluster    2855..14954
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2855..14954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[7854:9954](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      7855..9954
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            3608..4948
                     /locus_tag="CYFUS_RS15560"
                     /old_locus_tag="CYFUS_003078"
     CDS             3608..4948
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="CYFUS_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003078"
                     /product="cytochrome P450"
                     /protein_id="WP_095985940.1"
                     /sec_met_domain="p450 (E-value: 9.3e-74, bitscore: 248.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQADPHAPSPENLPLPPGRTGLPLLGETLDFLRSSRAFTEQRR
                     NQYGPVFRSHVLGSPAAFLTGPDAIQWIFAGEGKYLKNRWTPGVRRLLGANSLSLLEGE
                     EHLERRRLLAPHFSYATMRGFVPAIESLATRHFERWAALPGDFTLWPAMRELAFEIALS
                     LIFGQDTVDVPFLMRHFQAWTAGLFVPLAVNLPWTKFGRALAAKKAMITYLDQLVAERQ
                     KRTEQPPDLLGSLLRHRDGEEPLPRETIVEELQLLLFAGHDTTVTATSNLMLLLAQHPD
                     VLQKGREAVADMEGPLTLDGLRAMPYLVQLIHEGMRLIPPIGGAFRVTTRDVAFKGFRI
                     PKGWMVPVSIRTAHAGDHWPLPERFDPERFGSENNEQRKPGTFIPFGGGPRICLGQHFA
                     MVEMSVMLALLLKHYTWELVPGQDLSYLLVPFPQPRSGIQLRLRRRS"
     gene            complement(4993..5766)
                     /locus_tag="CYFUS_RS15565"
                     /old_locus_tag="CYFUS_003079"
     CDS             complement(4993..5766)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015346652.1"
                     /locus_tag="CYFUS_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003079"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_232537581.1"
                     /transl_table=11
                     /translation="MSTTASAISPSSAAPTSSSLPEGELQEGAQGPEVQRLQTVLVRLK
                     YLTARADGDFGPKTKTALQAFQSDWRLTPDGVYGPGTRAALLKALVPVYKPTVVSRPSP
                     NHEPRRGTDIDVILLHHTASNRASVDLATLRKGSGPNRVSAHYLVAPGGTLYQLVQDSR
                     AAWHAGVSSLRGETKPSVNLRSIGIELTNDGSGTTPFTEEQYRILERLVPYLARTYRVP
                     KENILGHRDVAPGRKTDPADNFDWARVRRAVDAVL"
     gene            5948..7432
                     /locus_tag="CYFUS_RS15570"
                     /old_locus_tag="CYFUS_003080"
     CDS             5948..7432
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002623372.1"
                     /locus_tag="CYFUS_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003080"
                     /product="glutamate-cysteine ligase family protein"
                     /protein_id="WP_095985942.1"
                     /transl_table=11
                     /translation="MGQALDKEEFTPEDVARFSARLEESLEALERVLARPGFGVGPRTL
                     GAELEAHLVDRGGRALGVCGEVLARARDRQLTVELGRFNVEFNAGVVSLAGRPFREFGE
                     DLTRMLARLRRAAGEVGGRVALVGVLPTLRLEDLEPSVLSPFARYRALQHGLRSHRARP
                     FRLHIEGEETLSLEMEYVSAASACTSMQYHLKVDPVDFARAHNAAQLAIAPVLALCGNS
                     PLFLGRRLWHETRIPLYRQATDGRSSEEESMELPSRTGFGHGWVRQGAHELFAQGVALH
                     SPLLPVVGQESPLEVVAGGGVPSLSELRMHQGTLYPWNRAVYDPSGGGHVRVEMRALPS
                     GPSVPDMLANGAFALGLTLSLMKEVEGLVTRMPFRCARTNFYRAAREGLDAPLYWPGLP
                     GQLLAVQPVRQLLPRLLARAREGLVAAGVDPEDVEPLFELLEGRLRTGRTGARWQLDML
                     ARLEADRPRNEALTAMFERYLAHSEEGMPVHTWPDV"
     misc_feature    7571..7581
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            7855..9954
                     /locus_tag="CYFUS_RS15575"
                     /old_locus_tag="CYFUS_003081"
     CDS             7855..9954
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="CYFUS_RS15575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003081"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_095985943.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.1e-197, bitscore:
                     657.3, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.7e-12, bitscore: 45.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKSAGLSASLGAHEAPRDAEPPAYPFRSGAIDMVFLCMPYASVE
                     RPSLALGTLAAVLNREGITTRSIHANLEFMARIGRLVYETINSTEITLQIGEWTFSEAV
                     FGPQPDIDGFVDGLVHRGYPRDGLREMLLGVRAEATKLVDDLAHQVLALKPGIVGCSSV
                     FQQHCASLALLRRIRELAPSVVTMLGGPNCEGEMGAATHQQYPWVDFVVSGEADSLLPE
                     LCRRIFTHGPGMAMELLPHGVLGPASRGADAAGINAGAPADAGRALIPRLDELPVPDFD
                     DYFEQLAASPLYEYVIPGLPIETSRGCWWGAKHHCTFCGLNGSGMEFRAKSQERVREEV
                     LQLSARYGIKKFLAVDNILDNKYFSKVLPFLAESGDMLWFYETKANLRREQVELLSRAG
                     VRWIQPGIEALDDGLLGLLRKGCSTVINVQLLKWAYDYGIWVVWNHLYGAPGEKPEWYE
                     RVADWLPLIVHLQPPSGGALTSIRFDRFSPYFNKPESFGLNLKPCWGYGQAYPVAPEQL
                     ARQAYFFFDDNPPRPPPLRLMERMADWASRFYASRSSLTALLRRSENAPVLEMSADGPR
                     LKIRDTRPCAVAPLHELTELEARVCHALDGALGAQALVQSLRRAGCDARDAEIEQVLQR
                     LVELKIVGDFGGRYLCLATDEHPVPYRSFGDFAGGLLSVNARRAQMSPEAPWDVSLSEL
                     FAASQ"
     gene            10001..10435
                     /locus_tag="CYFUS_RS15580"
                     /old_locus_tag="CYFUS_003082"
     CDS             10001..10435
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: TIGR03793"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03793.1"
                     /locus_tag="CYFUS_RS15580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003082"
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_095985944.1"
                     /sec_met_domain="TIGR03793 (E-value: 2.3e-18, bitscore:
                     64.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTPAPAPKPMSRRELEARIIAKAWKDPAYKQRLTSDPRGVLQ
                     EELQAIDPAIKLPGALQIQVHEENPNLFHLVLPRNPNDVKLSEVVGDNLEAVAPQTIVV
                     LVAAAIAVVVNAAAAANVNAAANVNAAANANSVANANSVV"
     gene            10602..12170
                     /locus_tag="CYFUS_RS15590"
                     /old_locus_tag="CYFUS_003083"
     CDS             10602..12170
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: PoyD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Proteusin_Epimerase_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04517.1"
                     /locus_tag="CYFUS_RS15590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003083"
                     /product="radical SAM family RiPP maturation amino acid
                     epimerase"
                     /protein_id="WP_095985946.1"
                     /sec_met_domain="PoyD (E-value: 2.7e-144, bitscore: 480.4,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Proteusin_Epimerase_RRE (E-value: 2.9e-24,
                     bitscore: 84.1, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHSPRDSQSNEMTYPEGMSMTEAQPATVSAHAWPPLTIGQAKRV
                     LEWWSSSAAFRERVMADPERAGHEYKLGFNPDLIRPLWDDGYHKDPANEGRPTHPVVEA
                     YRAFFRKKTQWREQVKKECAPDEPRFKAWRARQIARNAMENGQYDNGIIHAPFAIELND
                     GCSVGCWFCGVGATKFVETWRYTEENAALWRSVLKVMNAKIGAAARWGFCYWATDPLDN
                     PDYEHFAGDFADITGMYPQTTTAQGHKDPERVRKLLAVSESRGCLINRFSVLTEPLLRQ
                     IHAEYTPDELTRVEIVAQMRDATVPKANAGAFRALAKTRGNVLSMEQRKLAQLAGATRA
                     AADAGQEPTTVTVPQPGTIACVSGFLMNMVKRSIKLISPCRASEKWPLGYIVFEERTFT
                     DAADLQRSIEEMMATHMPLELKPEDPIRINPSFRLEPAPNGFRVMSPMTGVEFMRPDKA
                     EFIGSIGQLVGSGERTAGQIALSTLFQYGVPEVSTLGTLGAMFELGLLVDAQGRIAGEL
                     PGGAR"
     aSDomain        11859..12155
                     /aSDomain="Proteusin_Epimerase_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing epimerase in a proteusin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CYFUS_RS15590_Proteusin_Epimerase_RRE
                     .1"
                     /evalue="8.20E-27"
                     /identifier="RREFam010.1"
                     /label="CYFUS_RS15590"
                     /locus_tag="CYFUS_RS15590"
                     /protein_end="518"
                     /protein_start="419"
                     /score="84.1"
                     /tool="antismash"
                     /translation="LKPEDPIRINPSFRLEPAPNGFRVMSPMTGVEFMRPDKAEFIGSI
                     GQLVGSGERTAGQIALSTLFQYGVPEVSTLGTLGAMFELGLLVDAQGRIAGELP"
     gene            12167..13351
                     /locus_tag="CYFUS_RS15595"
                     /old_locus_tag="CYFUS_003084"
     CDS             12167..13351
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017026.4"
                     /locus_tag="CYFUS_RS15595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003084"
                     /product="methyltransferase"
                     /protein_id="WP_095985947.1"
                     /transl_table=11
                     /translation="MTPRLSTAVDGLRDHLDRVGFRQLYKYIATVNHYAVIPSLVTRDT
                     APAVHRFFDTVLEGAAEFALLQCLMTGRAAKHASLPDKDRVLADALVEAGLLRASPDGR
                     EVSGADRQLISAFGVDLLIDRRIHFGGDVHEVYIGPDSYWMLYYIDVASIRRDHRAVDL
                     CTGSGIAALYLSLFSDHVLATDIGDVPLALVEVNRRLNRREASVEIRRQDLRDTLEGRE
                     RFDLLTCNPPFVAIPPGYQGTLYAQGTGVDGLDYMRDIVARLPRVLNPGGSAYLVADLC
                     GDAHGPHFFGELERFAADDGMRIDAFIDHVLPASAQVGAMSSFLKRAARLPAEADVAAD
                     VVAFQRDTLRAEHYYLTTLHLRTAAPNPGLRVMRRGALPKSRSEDTWPALLLSS"
     gene            13324..15183
                     /locus_tag="CYFUS_RS15600"
                     /old_locus_tag="CYFUS_003085"
     CDS             13324..15183
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CYFUS_RS15600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003085"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_095985948.1"
                     /sec_met_domain="DUF4135 (E-value: 7.1e-83, bitscore:
                     278.0, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGAAALVVTTPDMMLHELLREEPDRATERMSEALRQRWQAQLGP
                     GRLARRLAWAAEGSSGPSTAPAHGEALLAAALENPEAPVLSGGLDPAAPIPFEEVLLPL
                     LVAARSELEREAGAALRLFTPSALASLERGLLVLLSHLALPVLGSEFSLRRALAGRLPW
                     LERPGSTDDYRSFVTAMRSGELGLLLREYPGLARLLAIAARGWVTAHGRLMVRLGRDWP
                     DLRASFGFSDGECRVEGIATSCSDPHDGGQSVAILHLTGARPLVYKPRPLDMDDGLREL
                     LGWANSAGFPWPFREVGLLPRQGYGWMEHVAAAPCDDEAAVTRFYVRSGALFCLWWLLQ
                     GTDIHHENLIANGEQPVIVDAETLLHPRPFPGVARGLGPGAGRGDDAEGDFARALRESG
                     FLPSGMAVDLSCWGTGGGLDTPFLVTRCRAVNSDAMAVCHEPFHVAPRPNLPVLHGRSV
                     PAAPHAEAIIDGFTAMFRLVLRERAGFLAVLDRFAGRGGRFVARATNVYGLLLGASLLP
                     EWLREGPARGVLYEQLRRAAVEETHRPACWPLLDAELAALEQLDVPRFTSRCDLPSPCW
                     PTPLDEARARVVSASEDALERHVAALRRALSRLVGETPCPEAT"
     gene            15196..16281
                     /locus_tag="CYFUS_RS15605"
                     /old_locus_tag="CYFUS_003086"
     CDS             15196..16281
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_003086"
                     /product="hypothetical protein"
                     /protein_id="WP_157758461.1"
                     /transl_table=11
                     /translation="MSVEQQVRTVLHLLTGNAPRSASGPGGPGNFAPAARAMVAATGGF
                     QSPGPSPVETPDWMTDSCIQALGLGEKETCGVMGSDVALKVYVEKKLPKSRLGKPVPKV
                     VSLDGMAPILTDVVEIGKVRLQSNTQRIRPALPGFSVSRAEDPPNTGTFGLVVRKKGQA
                     SPFYLLSNCHAIAASGLANKGDIIIQPGAADEGVATADRIGALSEWVPFDFTPNSTQNN
                     IDAAIAQLDDNVASAAIALLGVPTGVNTTLTRGMYVQKVGRTTSLSVARITDVDLVLNL
                     SYPTASGLQLATMRDQVLVTFYSNPGDSGSSVLDMDNKVVGLHVAGSSVVGIFCKIGNV
                     LERLGLEVVTQDNLGTPVTTG"
     gene            16294..16557
                     /locus_tag="CYFUS_RS15610"
                     /old_locus_tag="CYFUS_003087"
     CDS             16294..16557
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_003087"
                     /product="hypothetical protein"
                     /protein_id="WP_095985950.1"
                     /transl_table=11
                     /translation="MASEQEARRLLSAVSGHLTALPNVIGVGVVPAEGKSSEACIAVYV
                     RSKVPKAALKPEELVPETVKGQVDGVSLQAPTRVIEVGDLRF"
     gene            complement(16547..18199)
                     /locus_tag="CYFUS_RS15615"
                     /old_locus_tag="CYFUS_003088"
     CDS             complement(16547..18199)
                     /NRPS_PKS="Domain: Abhydrolase_1 (279-390). E-value:
                     1.8e-09. Score: 29.5. Matches aSDomain:
                     nrpspksdomains_CYFUS_RS15615_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF023568.4"
                     /locus_tag="CYFUS_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003088"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_095985951.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.6e-09, bitscore:
                     36.4, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.3e-06, bitscore: 25.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMPSWARLLFAGQPTLFYRVTMLDRVCVEQWTTYHGEEQGELHRL
                     TFLAEVDPAAMGSGGAKLRLRGELWCTPALEPVRYSLQGDNVRLQLRFSANQVDVLLPD
                     GSTQSLDRAGATFLSDGNFPATLALIYAAMSGGAAPPPVEHLKLKLFVANTLVTVPYET
                     SPAEDLVASSGRWHRTSHRTEVLLDESGVMLEARSPDSGFSATLIRQGPPVPDWPDPLV
                     PGAPPLAYRPPQSARFRLEDVEIAGPVTPLGATLSIPPGKGPFPAVLFISGSGTHDRHG
                     IAGEIDLGSHEVMDDLAAHGFVGLRFDTRGAGTTGLGADFLDRGLGADITDARACLAYL
                     SARPEAAGQPLFLIGHSQGATIAMVLAGESSSEPGVRGVVLMAAMGRDLDEVLADQILA
                     HGQRLGLSEAQIEAQQADTRKVAELIRSGSPWDAEQLPHHLLATFRTRTWYEEFLRHPT
                     SELIGKVRCPMLLCQGGEDFQVSPERDAERLLAAACRSGRDCTYALFPGLDHLFKRTRG
                     QSSLAEYFEPRPVAPEFLARLRTWLASRAGLKT"
     aSDomain        complement(17030..17362)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CYFUS_RS15615_Abhydrolase_1.1"
                     /evalue="1.80E-09"
                     /label="CYFUS_RS15615_Abhydrolase_1.1"
                     /locus_tag="CYFUS_RS15615"
                     /protein_end="390"
                     /protein_start="279"
                     /score="29.5"
                     /tool="antismash"
                     /translation="HGIAGEIDLGSHEVMDDLAAHGFVGLRFDTRGAGTTGLGADFLDR
                     GLGADITDARACLAYLSARPEAAGQPLFLIGHSQGATIAMVLAGESSSEPGVRGVVLMA
                     AMGRDLD"
     CDS_motif       complement(17099..17155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CYFUS_RS15615_0001"
                     /evalue="8.40E-04"
                     /label="NRPS-te1"
                     /locus_tag="CYFUS_RS15615"
                     /protein_end="367"
                     /protein_start="348"
                     /score="12.0"
                     /tool="antismash"
                     /translation="QPLFLIGHSQGATIAMVLA"
     gene            complement(18196..18630)
                     /locus_tag="CYFUS_RS15620"
                     /old_locus_tag="CYFUS_003089"
     CDS             complement(18196..18630)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022338.4"
                     /locus_tag="CYFUS_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003089"
                     /product="PH domain-containing protein"
                     /protein_id="WP_095985952.1"
                     /transl_table=11
                     /translation="MHVYQMAPHGSRGVLWVIFVTLLLVLVVLLLALRAPKFEISNEGL
                     RIRGSPFGREIPAAALRLESARIVNLRESPDLAPKWRTMGVGLPGYRAGWFRLQNGEKA
                     LVFLGRGEEALYIPTSEGYALLIAPEDLAGCLRTLKGAPA"
     misc_feature    18790..18804
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.46"
                     /tool="antismash"
     gene            19353..19817
                     /locus_tag="CYFUS_RS50600"
     CDS             19353..19817
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS50600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157758462.1"
                     /transl_table=11
                     /translation="MTLTTALVLASSGCAHSQRPESRIHVVSEQSEGVGSALGSGGSGG
                     YDCNDEFKKCMKVCWDKRYPWPHNKRQSGWYHERCEQDCNRAFNEYEDEKKKEEERQGK
                     LTFSHMDEAIDWIKNHKAEVMIGTVVIVAGVAFVLSTGGYGTLILAPLAL"
     gene            19823..20227
                     /locus_tag="CYFUS_RS15630"
     CDS             19823..20227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002623376.1"
                     /locus_tag="CYFUS_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_332468374.1"
                     /transl_table=11
                     /translation="MKMIYNKDFDVDSVLEILRVIDEKYQEGSPEDEALRIAAVALFYV
                     RESQKINDYREFFRKFYTPAADYIVPSHEFATREEADEWLASGNATEGELVKIAGEGFR
                     VIPLRDAKGLRFRPTPLPEELDKMNPPGSE"
     misc_feature    complement(19824..19838)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.9"
                     /tool="antismash"
     misc_feature    complement(19829..19845)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            complement(20236..20781)
                     /locus_tag="CYFUS_RS15635"
                     /old_locus_tag="CYFUS_003092"
     CDS             complement(20236..20781)
                     /GO_component="GO:0031966 - mitochondrial membrane
                     [Evidence IEA]"
                     /GO_process="GO:0033617 - mitochondrial cytochrome c
                     oxidase assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014667.4"
                     /locus_tag="CYFUS_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_003092"
                     /product="SCO family protein"
                     /protein_id="WP_095985955.1"
                     /transl_table=11
                     /translation="MSTLRPGSALPVGGAFDLVDHDGRPVTHETFRGAYALVFFGFTHC
                     RVVCPRALGRLSTVLGLLGPDAARMQPLYITVDPERDHPSVMKAFLARWPGFLGLTGSR
                     EQIEAAKAAFHVFARRRDDPEDPNGYAVPHTAITYVIDPEGVCVDHFTDALSADEVAER
                     LRTLIARNHRLNASEAGE"
     misc_feature    21294..21306
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    21363..21377
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    21829..21844
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    21942..21953
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 gggatcccga tcagctcgac gtggcctggg cggtgcggat gagcatgagc cttcccttct
       61 tcttcgagcc cgtgcgactc gaggatggtc agggccacac gagcttcatc gtggacggtg
      121 gcgtgctcag caacttcccc gtcgacatcc tcgatgacga gagcgcccat ccgcggtggc
      181 ccacgttcgg actcaagctg gtggagcgga cgcgggcgga tggccgggag gaggtggtgc
      241 cgtgccgcat ccaggggccc gtctcgctgc tcaaggcggt gatctccacc atgctcgagg
      301 cgcacgacac gcgctacatc gagcagaaga acttcgatcg caccatcgcc atccccaccc
      361 tgggcgtgaa gaccacggac ttcggtctgc gcgaggaaca ggtccacgcg ctgtaccagg
      421 cgggctacac ggccgccgag cggttcctcc agacgtggga cttccagggg tggatccgga
      481 ggtaccgcca gtccgagccg ccgagccagg agacggcggg cgagagggcc cgggagggta
      541 tcacggccct ggcggcgtcg atgtgagggg ggtccgttcg tgggaggagg cgcgtgatgg
      601 ctcctccacg agcgcctggc tggcggcttc ccgtccgccc cttgggaaaa atcctgtccc
      661 cgaggacaat cgcccgagcc gcgccgcgag cccatccccg cgagtgccgc cacgcagcca
      721 tggcgaacct ccccatgccc gagacactcc cctccgccca tccgccaccc gagcctcggg
      781 aggaggcttc cgcgcccccc atgctccgct cctggctctg ggagcagctg gactcgatgc
      841 tctcggagtc cctgcggcgg gcggagccct cggagctcat ccgctaccgg atcatggtcg
      901 gcgccgcctg cttcttctcg ctgatcaacg gggtgttcct gctgcgctcc ttctcgcagg
      961 gcaacttccc gtatgcggcc atcctcgcca gcttcggcta cgtggggact ttggtgttgg
     1021 cgcgcagggg ccgcacgccc atcgcgcccg cgatggtcct gctggcgacc ctgaccctgg
     1081 ggctggtgat caccaccttc acgagcagga aacccacggg cggcgatcat gccgtgaaca
     1141 tgttgctgcc cgtcctcgcg gtgtacctgg tggggccacg actggggttg tccatcaccc
     1201 tcgccctgtt cgtgacgctg ggcctcatcc acccgtatta ccggtcgcag gtgggcatcg
     1261 atcccagcac cctcaccctc agcggcctct ggttcagcca tgtgttcgcg ggcatctcct
     1321 ccctgggcgt gtgggccctg agctcgctgc acagcaccgc gcgcgacgcg gcgcaggcca
     1381 ccatcgagcg gacggtgcgg gagcttcgcg acagccagag caagctcaac agcgtcttcg
     1441 agagcaccga cgacatcgtg gtctcgatcg attcacaagc gcgcctgctc accgcgaact
     1501 cggccgcgag gttcatctac gagcaccgcg gcggcatcgt gctcgagccc gggatgccgc
     1561 tcttccagca tgaggcgccc gagatccgca aggcctggga tgcccggctc gtccaggtgc
     1621 tccagggcca gcgcctgcgc ttcgagcaga cctaccagga ccagcagggc ctgttggtgc
     1681 tggacaccag cgtgcatccc atcgtggagg agggaggccg ggtcgtgggg atgacgatct
     1741 tcggccgtga tgtcaccgcc cggaggcagg ccgaggcccg gttgggggag atgcaccgca
     1801 ccctggtgga cgtgtcgcgc caggcgggca tggccgaggt cgccacgggc gtgctccaca
     1861 acgtgggcaa caccctcaac agcgtgaaca tctccaccag cctcgtcatc gatcagctcc
     1921 gcaagtcccg ggtgacgagc ctcgcccggg tcgccaccct gctgcgtgag cacctcgccg
     1981 acctccccgc cttcttcgcc cgggatgccc agggccagca gctgccgccc ttcctcatcg
     2041 cgctgtccgc gcagctccag gaggagcggg cggccatgct ccgggagatg tattccctgg
     2101 gggagagcgt cgagcacatc aactccatcg tcagcatgca gcagaagcac gcgcgggccg
     2161 cgggcgccgt ggagcatgtg gccgtgccgc agctcatcga cgaggcgttg cgcctgcatg
     2221 ccgtctcctt cgatcgtcaa cgcatccagg tcgagtgcga ctacgccgag gtgcccccca
     2281 tcttcgtgga tcggcacaag ctgctgcaga tcctgatcaa cctggtgagc aacgcgcggc
     2341 acgcgctggt ggcgagtccg aagacggaca agcggatggg catccacgtg cggcgcgcac
     2401 ccgatccggg gcatctgcac atcgaggtga ccgacaatgg ggtgggcatt gctccggaga
     2461 acctggggcg catgttctcc cagggcttca ccacgaagaa gatggggcac ggcttcggcc
     2521 tgcacatcag cgccctggcc gccgccgaga tgaaggggcg gctgtcctgc tccagtcctg
     2581 gtctggagca gggtgccacc ttcctcctcg atctgccgat gcagaccgag gtccccccgg
     2641 tccaggagga cgcggaaccc tcatgagggt caggcccttc gccagagcag ggcgagcagc
     2701 cggggtacgt ccgagcgcgg tgcacccggg tcccggcaat ccctcgctcg caccagcacg
     2761 aagcccgcgt ccgcggccgc gttcaggtac tccgagacgt cgtgcaggtg gctgcggacg
     2821 ttctggaggg cgccggtgtc cgggtccacg aagtacgcct gcttgccctg gagctgccgg
     2881 aaggggtgca gctcgcagac gaagagcgcg ccgcctggcc tgagcactcg cctcgcctcg
     2941 gagaagacga aggacagctc ctcgatgtgc tccagcacca ggttgcaggt gacggtgtcg
     3001 cgagaggcct ccgcggcggg ccagcgctcg cgcaggtcct gcaggaagaa ctggacgtgt
     3061 tgaacccccg ggcgctcgcg ggcgcggttc aacatcttct ccgaggcatc gagcgcgagc
     3121 aggctgcggg cctggggggc gagccactcg gtgttcttcc cggtgccgca gccgatctcc
     3181 aggacgtcac ctcggaagag ggacggctcc tggtcgtgga ggatggcggc gtcgaggtca
     3241 cgcgtggcgt tggcctgggt gtcgtacacc tcggaccaga cgtcgtacgc ggtcgccact
     3301 tcgtcggggg gacgcttcgt ggtcatcttc atctcctccg tggggaggtg acgaaggctc
     3361 gccaccttcc cgtgtctggg gcctcgcggc ccacgggttc aggtgacgta gctttgttcg
     3421 ccccctcgag gaggaggccc gcagcagcgt cactgctgcg gtccagcggt cgtctggcta
     3481 ccacgccctc gaggggggtg tcaaagcgct ccgtttcctc ggggaggggg ctctctttcc
     3541 cgtgaggtag gattgtaatc tttcatctcc aagggccact tcctcccatg gcccggagac
     3601 gcgcgacatg actgcccagg ccgatcccca cgctccctct cccgagaacc ttccgcttcc
     3661 gcccggcagg acgggactcc cgctgctcgg ggagacattg gacttcctgc gctccagccg
     3721 tgccttcacc gagcaacggc ggaaccagta cggccccgtc ttccgctcgc acgtgctggg
     3781 ctcgcccgcc gcgttcctga ccggcccgga cgccatccag tggatcttcg cgggagaggg
     3841 caagtacctg aagaaccgct ggacgccggg agtccgccgg ctgctcggag ccaacagcct
     3901 gtcgctgctc gagggcgagg agcacctgga gcggcgccgc ctgctcgcac cccacttcag
     3961 ctacgcgacg atgcgcgggt tcgtgcccgc catcgagtcg ctcgccacgc ggcacttcga
     4021 gcgctgggcg gcgctcccgg gggacttcac cctgtggccc gccatgcgcg agctggcctt
     4081 cgagatcgcc ctgtcgctca tcttcggcca ggacaccgtg gacgtgccgt tcctgatgcg
     4141 ccacttccag gcgtggacgg cggggctctt cgtccccctg gcggtgaacc tgccctggac
     4201 gaagttcgga cgggcgctcg ccgcgaagaa ggcgatgatc acctatctgg atcagctcgt
     4261 cgccgagcgg cagaagcgga ccgagcaacc gccggatctg ctgggctcgc tgctgcggca
     4321 ccgggacggg gaggagcccc tgccgcgaga gacgatcgtc gaggagctgc agttgctgct
     4381 cttcgccgga cacgacacca ccgtcaccgc cacctccaac ctgatgctgc tcctggccca
     4441 gcacccggac gtgctccaga agggccgcga ggcggtggcg gacatggagg gccccctcac
     4501 gttggatggg ctgcgggcga tgccctacct cgtgcagttg atccacgagg gaatgcgcct
     4561 cattccgccc atcggtgggg ccttccgcgt caccacgcgg gacgtggcct tcaagggctt
     4621 tcgcatcccc aagggatgga tggtgcccgt gagcatccgg acggcgcacg cgggcgatca
     4681 ctggcccctc ccggagcgct tcgatcccga gcgcttcggc tccgagaaca acgagcagcg
     4741 caagccgggc acgttcatcc cctttggggg gggaccgcgc atctgcctgg ggcagcactt
     4801 cgcgatggtg gagatgagcg tgatgctggc gctgctgctc aagcactaca cgtgggaact
     4861 cgtgccgggg caggatctct cgtacctcct ggtgcccttc ccccagcccc ggagcggcat
     4921 ccagctgcgg ttgcgccggc ggagctgaga ccacgcgcct gcctgagccg cgccgcccgg
     4981 tgaagcgtca cgtcagagga cggcgtccac ggctcggcgc acacgggccc agtcgaagtt
     5041 gtcggcgggg tccgtcttgc ggcccggggc cacgtcacgg tggccgagga tgttctcctt
     5101 gggtacccgg tacgtacggg ccaggtacgg cacgagccgc tccaggatgc ggtactgctc
     5161 ttccgtgaag ggcgtcgtgc cggagccgtc gttggtgagc tcgatgccga tggagcgcag
     5221 gttgacgctg ggcttcgtct ccccgcgcag cgaggacacc ccggcatgcc aggcggctcg
     5281 cgagtcctgc accagttggt agagcgtccc tccgggtgcc accaggtagt gcgcgctcac
     5341 gcgattgggg ccgctgccct tgcgcagcgt ggccaggtcc acgctggctc ggttggaggc
     5401 ggtgtggtgc aggaggatga cgtcgatgtc cgtgccccgg cgcggctcgt ggttgggaga
     5461 gggccgggag accaccgtcg gcttgtagac gggcaccagg gccttgagga gcgccgcgcg
     5521 cgtgccgggc ccatagacgc cgtccggggt gagccgccag tcgctctgga aggcctggag
     5581 cgcggtcttc gtcttcggcc cgaagtcccc atccgcccgg gctgtcaggt acttgagccg
     5641 cacgagcacc gtctggagtc gttgcacctc gggtccttgc gcgccctctt ggagctcacc
     5701 ctcgggcagc gacgaggagg tcggagcggc ggaggaggga gatatggcgg aagcagtagt
     5761 ggacatgggt tcgatcatac cgggaagcca ttcggcgagc cgctggctgg cggccaactg
     5821 tccagccgag cgctgaagga cacgcccgcg agagttggct cgcccacggc attggccgcc
     5881 agcccatggg gggctccctc tgctggaggg aggctcccta tcttgaatgt gacgacagga
     5941 ggcctccgtg ggtcaggccc tcgacaaaga ggagttcact ccggaagacg tggcgcgctt
     6001 ctcggcgcgg ctggaggagt cgctcgaggc gctggagcga gtccttgccc gtccaggctt
     6061 tggcgtgggg cctcgcacgt tgggtgccga actggaggcg cacctcgtgg accgtggagg
     6121 gcgcgccctg ggtgtctgcg gggaggtgct cgcgcgtgcc cgtgatcgtc aactgacggt
     6181 ggagctgggc cgcttcaacg tcgagttcaa cgcgggggtg gtgtcgctgg ccgggaggcc
     6241 gttccgcgag ttcggggagg atttgacgcg catgctcgcg cggctgcgac gcgccgcggg
     6301 cgaggtcggc ggccgggtag cgctcgtggg cgtgctgccg accctgcggc tggaggatct
     6361 ggaaccgagc gtgctgtctc ccttcgcccg ctaccgcgcc ctccagcatg gcttgcggag
     6421 ccaccgcgcg cgtcccttcc ggctccacat cgagggcgag gagacgctca gcctcgagat
     6481 ggagtacgtc agcgcggcga gcgcttgcac ctcgatgcag taccacctga aggtggatcc
     6541 ggtggacttc gcgcgagcgc acaacgccgc ccagctcgcc atcgccccgg tgctcgcgct
     6601 ctgcggcaac tcgcccctct tcctcgggcg ccggttgtgg cacgagacgc gcatcccgct
     6661 ctaccgccag gcgacggacg ggcgctcgag cgaggaggag tcgatggagc ttccctcgcg
     6721 cacgggcttt ggccacggct gggtgcggca gggcgcgcac gaactcttcg cccagggggt
     6781 ggcactccat tcccccctgc tcccggtcgt gggccaggaa tcaccgctcg aggtcgtggc
     6841 cggtggtggg gtaccgagcc tgagtgagct gcggatgcat cagggcaccc tctatccctg
     6901 gaaccgcgcg gtgtacgacc cctcgggtgg tggccatgtg cgggtggaga tgcgtgcgct
     6961 cccctcgggg cccagcgtgc cggacatgct ggccaatgga gccttcgcgc tcggactcac
     7021 cctgtcgctg atgaaggagg tggaggggct cgtgacgcgg atgccgttcc gctgcgcgcg
     7081 cacgaacttc taccgcgcgg cgcgcgaggg gctggacgcg cccttgtact ggccgggcct
     7141 ccctggccag ctcctcgcgg tccagcccgt ccggcaactc ctgccccgcc tgctggcgcg
     7201 ggcgcgggag gggctcgtcg cggcgggggt ggacccggag gatgtggagc cgctcttcga
     7261 gctcctcgag ggccggctgc gcacgggccg caccggagcg cgctggcagc tcgacatgct
     7321 cgcacggctc gaggcggacc ggccccggaa cgaggcgctc accgcgatgt tcgagcgcta
     7381 cctggcgcat tccgaggaag gcatgccggt gcatacctgg ccggatgtgt gaggatccgg
     7441 tttcatccat acctgccaac agccattccc atcccagtca gtgatgctgg ctcttctttc
     7501 gctgcaatgg cctggcggcg cccctctgag acagtctccg cgagcgtttg gagccggagt
     7561 ccctaccaga ttcaatgtca cggttgggcc acggacttga aaccgctggt tgggcatcag
     7621 aatccgtacg gcttgttcta tacttgacgg attaccagac ggaacggcag ccgggcccac
     7681 tcagccgcag gcgccgcgcg gtggtgatga attcccaaga aaagtttctc caccatcttc
     7741 tttgtatggt acgacgaggc cgcaaccggt tggcttgtcc gggattgcgt cgagagagcg
     7801 cgtaggggca ggaaaccttg tacgccgcat aagaccgcgg gggggaaagg tcgaatgagc
     7861 aagagcgcag ggttgtcggc ttcgcttgga gcgcatgagg ccccacggga tgctgaaccc
     7921 ccagcgtatc cgttccgctc cggcgccatt gatatggtgt tcttgtgcat gccctatgcg
     7981 tccgttgagc ggccgtcgct cgctctcggc acgctggccg cggtgttgaa tcgggaggga
     8041 atcaccaccc ggtccatcca tgccaatttg gagttcatgg cccgcatcgg ccggctggtc
     8101 tacgaaacca tcaacagtac agagatcacc ctccagatcg gagagtggac cttttccgag
     8161 gcggtgttcg gaccccagcc tgacattgac ggcttcgtcg acgggctggt tcaccgcggc
     8221 tatcccaggg acgggctgag ggagatgctg ctgggcgtgc gcgccgaggc cacgaaactc
     8281 gtggatgatc tggcccacca ggttctggcg ctgaagccag ggattgtcgg ttgcagctcg
     8341 gtcttccagc agcattgcgc ctcgctcgcg ctgctccgcc gcatccggga actggctccc
     8401 tcggtggtga ccatgttggg agggccgaat tgcgaggggg agatgggcgc cgccacgcac
     8461 cagcagtacc cgtgggtgga cttcgtcgtc tccggcgagg ccgactcgct gctgccagag
     8521 ctctgccggc ggatcttcac ccatggtcct gggatggcga tggagctgct gccccatggc
     8581 gtcctcggtc ctgcctctcg aggtgccgac gccgcgggaa tcaatgccgg agcgccggcc
     8641 gatgccgggc gtgcgctgat ccccagactc gacgaactgc cagtgccgga tttcgatgac
     8701 tacttcgagc agttggcggc ctcgccgctg tacgagtatg tcattccagg cctgccgatc
     8761 gagacctccc gcggctgctg gtggggcgcc aagcaccatt gcaccttctg cggcctgaac
     8821 ggttccggca tggagttccg cgccaagtcg caggagcgtg tacgagagga ggttctccag
     8881 ctctcggccc gctacggcat caagaagttc ctcgcggtcg acaacatcct cgacaacaag
     8941 tacttctcaa aggtcctgcc tttcctcgcc gagtccggcg acatgctgtg gttctacgaa
     9001 accaaggcga atctccgccg ggagcaggtg gagttgttgt cccgagccgg ggtgcgttgg
     9061 atccagccgg gcatcgaggc gttggacgat gggctgctgg ggttgctgcg caagggctgc
     9121 tcgaccgtca tcaatgtgca gctgctgaaa tgggcctatg actacggtat ctgggtggtt
     9181 tggaaccatc tgtacggcgc gccgggggag aagcccgagt ggtacgagcg tgtcgccgac
     9241 tggctgccat tgatcgtgca tctgcagcca ccgtcgggtg gtgccttgac cagcatccgc
     9301 ttcgaccgtt tcagccccta cttcaacaag ccggagagct tcggcctgaa cctcaagccc
     9361 tgctggggtt acggacaggc ctatccggtg gcgcccgagc agttggcgcg gcaggcttat
     9421 ttcttcttcg acgacaaccc gccccgcccg ccgccactgc ggctgatgga gcggatggcg
     9481 gactgggcga gccggttcta tgcctcgcgc tccagtctga ccgcactgct ccggcgcagc
     9541 gagaacgcgc cggtgctgga gatgagcgcc gacggccccc gcttgaagat ccgcgacacc
     9601 cggccctgtg ccgtggcgcc gctgcacgag ttgaccgagc tggaagcacg ggtctgccat
     9661 gccctcgacg gcgcgcttgg agcgcaagcg ctggtgcaga gcctgcgccg cgccggatgt
     9721 gacgcgcggg acgcggagat cgagcaggtc ctccagcggt tggttgagct gaagatcgtc
     9781 ggggatttcg gcggaaggta cctctgcctc gccaccgacg agcacccggt tccctatagg
     9841 tcgttcggtg atttcgccgg cggtctgctc agtgtcaacg cccgccgggc gcagatgagc
     9901 cccgaggcac cctgggatgt ctcgttgagt gagttgttcg ccgcctccca gtagccgtag
     9961 cagcgtccgt cccgcgacac cgccacgaaa ggaacagcag atgaccacca ccacgcccgc
    10021 ccccgcgccg aagccgatga gccggcgcga attggaagcc cgtatcatcg ccaaggcctg
    10081 gaaggacccg gcctacaagc agcgcctgac cagcgatccc aggggggtgc tgcaggagga
    10141 gttgcaggcc atcgacccgg cgatcaagct gcccggcgcc ctgcagatcc aggtgcacga
    10201 ggagaacccc aacctcttcc acctagtgtt gccgcgcaat ccgaacgacg tcaagctgag
    10261 cgaggtggtg ggcgacaacc tcgaggcggt ggcgccccag accatcgtcg tgctggtggc
    10321 ggcggccatc gccgtggttg tcaacgccgc ggccgcggcc aacgtcaacg ccgcggccaa
    10381 cgtcaacgcc gcggccaacg ccaacagcgt ggccaacgcc aactccgtcg tttgaggggg
    10441 accgcccccc cagcatcccg cttccctcgc attcaggcga gcggggtgtc gaacctccag
    10501 cgggtggtcg tcgcctgatc acccgcagtc cccaaccgag cccctagagg aggggcaccc
    10561 ccgagcccgg gccctcccac gccccagaag atgagttgcc catggaccac agccctcgcg
    10621 attcgcagag caacgaaatg acctacccgg aggggatgag catgactgaa gcgcagcccg
    10681 ctacggtgtc cgcgcatgcc tggccgccgc tgacgatcgg tcaggccaag cgcgtgctgg
    10741 aatggtggtc gtcctccgcc gcattccgcg aacgggtcat ggccgatccg gagcgcgccg
    10801 ggcatgagta caagctgggg ttcaaccccg acctgatccg cccgctctgg gacgacggct
    10861 accacaagga cccggccaac gaagggcggc ccacgcatcc ggtggtcgag gcctaccgcg
    10921 cgttcttccg gaagaagacg cagtggcgcg agcaggtcaa gaaggagtgc gctcccgacg
    10981 aaccgcgctt caaggcctgg cgagcccgcc agatcgcgcg aaacgccatg gagaatggcc
    11041 aatacgacaa cggcatcatc cacgcccctt tcgccatcga gctgaacgat ggttgctcgg
    11101 tcggctgctg gttctgcggg gtcggcgcga cgaagttcgt cgaaacctgg cgctacacgg
    11161 aggagaacgc agcgctgtgg cgctcggtgc tgaaggtgat gaacgccaag atcggcgccg
    11221 ccgccaggtg gggcttctgc tactgggcga ccgacccgct ggacaacccg gattatgagc
    11281 acttcgctgg cgacttcgcc gacatcacgg gcatgtaccc gcagacgacc accgctcagg
    11341 gccacaagga ccccgagcgg gtccgcaagc tgctcgcggt ctcggaatcg cgtggctgtc
    11401 tgatcaaccg cttctcggtc ctgaccgagc cgctgttgcg gcagatccac gcggagtaca
    11461 cgccggacga gctgacccgg gtcgagatcg tcgcccagat gcgcgacgcg acggtgccca
    11521 aggccaatgc cggcgccttc cgggcgctgg ccaagacccg cggcaatgtc ctgtcgatgg
    11581 agcagcggaa gctggcgcaa ctggccggag ccacccgcgc cgcggccgac gcggggcagg
    11641 agccgacgac ggtgacggtg ccgcagcccg ggaccatcgc ctgcgtctcg ggcttcctga
    11701 tgaacatggt caagcgctcc atcaagttga tcagcccctg ccgggcctcc gagaagtggc
    11761 cgctcggcta catcgttttc gaggagcgca ccttcaccga cgccgccgac ctgcagcgtt
    11821 cgatcgagga gatgatggcc acccacatgc cgctcgagct caagccggag gatccgatcc
    11881 gtatcaaccc gagcttccgg ttggagccgg cgcccaatgg cttccgcgtg atgtcgccga
    11941 tgacgggcgt ggagttcatg cgccccgata aggccgagtt catcggctcg atcggccagc
    12001 tcgtcggctc gggggagcgc acggcggggc agatcgcgtt gtcgaccctg ttccagtatg
    12061 gcgtgcccga ggtgagcacg ctcggcaccc tgggcgcgat gttcgagctg gggctgctgg
    12121 tcgacgcaca gggccgcatt gccggcgaac tcccgggtgg ggcgcgatga cgccgcggct
    12181 ctccaccgcc gtcgacgggc tgcgcgacca ccttgaccgg gttggctttc gccagctcta
    12241 caagtacatc gcgacggtga accactatgc cgtgattccc tccctggtca cgcgcgacac
    12301 ggcccccgcg gtccaccgct tcttcgacac ggtgctggag ggcgcggcgg aattcgccct
    12361 gctgcagtgt ctgatgaccg ggcgcgccgc gaagcatgcc tccctgccgg acaaggatcg
    12421 ggtattggcc gacgcgctgg tggaggccgg gttgctgcgg gcaagcccgg acgggcgcga
    12481 ggtctcgggc gctgaccgcc aattgatctc ggccttcgga gtggacctgc tgatcgaccg
    12541 gcggatccac ttcggcggcg acgttcacga ggtctacatc gggccagaca gctactggat
    12601 gctctactac atcgatgtcg ccagcatccg ccgggaccat cgtgccgttg acctctgcac
    12661 cggcagcggc atcgccgcgc tctatctctc gctgttctcc gaccatgtcc tggccaccga
    12721 cattggcgac gtgcccctgg ccctggtcga ggtgaaccgc cgcctgaacc ggcgcgaggc
    12781 gtcggtggag atccgacgcc aggacctccg cgacaccctc gagggccggg aacggttcga
    12841 cctgctcacc tgcaacccgc ccttcgtggc catcccgccc ggctaccagg gcacgctcta
    12901 tgcccaggga accggcgttg acggcttgga ctacatgcgc gacatcgtcg cccgcctgcc
    12961 cagggtgctg aacccgggcg gctcggccta cctcgtcgcc gatctgtgcg gcgatgccca
    13021 cggtccgcac ttctttgggg aactggagcg cttcgccgcg gacgacggca tgcgaatcga
    13081 cgcgttcatc gaccatgtcc tgccggcctc ggcgcaggtc ggcgcgatgt cttccttcct
    13141 gaagcgtgcc gccaggctgc ccgccgaagc cgacgtcgcc gccgacgtgg tggcgttcca
    13201 gcgcgacacg ctgcgcgccg agcattacta cctgaccacg cttcacctgc ggaccgcggc
    13261 gccgaatccc gggctgcggg tgatgcgacg cggggccttg ccgaagagcc gctcggagga
    13321 cacatggccg gcgctgctgc tctcgtcgtg accacgcccg acatgatgct gcacgaactc
    13381 ctgcgagagg agccggaccg cgccacggaa cggatgagcg aggcgctccg tcagcgttgg
    13441 caggcacagt tgggaccggg ccgccttgcc cggcggctgg cctgggcggc ggaggggtct
    13501 tccggcccgt ccacggcccc agcccacggg gaggccttgc tggcggcggc gctggagaac
    13561 cccgaggccc ccgttctgtc cggcggcctc gaccccgcgg cgcccattcc cttcgaggag
    13621 gtgctcctgc ccctgctcgt tgccgcccgg tccgagctgg agcgggaggc cggtgcggcg
    13681 ctccgactct tcacgccgtc ggcgctggcc agtctggagc gtggcctgct cgtattgctc
    13741 tcccatctcg ccttgcccgt tctcgggtcc gagttctcgc tgcggcgggc gctcgccgga
    13801 cgattgccgt ggctcgagcg cccggggtcc accgacgatt accggtcctt cgtcaccgcg
    13861 atgcgctccg gggagctcgg actgctgttg cgggaatacc ccggcctggc ccgtctgctg
    13921 gcgatcgccg cacggggttg ggtgacagct catggccggc tcatggtgcg tctcggccgg
    13981 gactggcccg acctgcgcgc cagcttcggc ttctccgacg gcgagtgccg ggtggagggg
    14041 atcgcgacat cctgctccga ccctcatgac ggagggcaga gcgtggccat cctgcacctg
    14101 acgggggccc ggcccctggt ctacaagccg aggcccctcg acatggacga cggcctgcgg
    14161 gagttgctcg ggtgggcgaa cagcgcgggc tttccctggc cgttccgcga ggtaggcctg
    14221 ctgccccggc aagggtatgg atggatggag catgtggccg ccgccccgtg cgatgacgag
    14281 gcggccgtca cgcgtttcta tgtccgttcc ggggcgctgt tctgcttgtg gtggctcctg
    14341 cagggcaccg acatccacca cgagaacctg atcgcgaacg gtgagcaacc ggtgatcgtc
    14401 gatgccgaga cgctcctgca cccacgcccc ttcccgggcg tcgctcgcgg cctcggcccc
    14461 ggcgccggcc gcggtgacga cgcggaaggg gacttcgccc gggcgctgcg cgagagcggc
    14521 ttcctgccct ccggaatggc cgtggatctt tcctgctggg gtactggcgg agggctcgac
    14581 actcccttcc tggtgacccg gtgccgagcg gtcaactcgg acgccatggc cgtgtgccat
    14641 gagcccttcc atgtggcgcc gcggcccaac ctgcccgtgc tgcacggccg gagcgtgccg
    14701 gctgcacccc atgcggaggc gatcatcgac ggcttcaccg cgatgttccg gctggtgcta
    14761 cgcgagcgcg cgggcttcct ggcggtgctc gaccgtttcg ctggccgcgg cgggcgcttc
    14821 gtggcacggg cgaccaatgt gtatgggttg ttgctcggcg cctccctgct gcccgagtgg
    14881 ctgcgcgagg gtccggcccg gggggttctt tacgagcagt tgcgccgtgc ggcggtcgag
    14941 gaaacgcacc gtccggcatg ctggccgcta ctcgacgccg agctggccgc gctggagcaa
    15001 ctggacgtgc cccgcttcac cagccgttgc gatctgccct cgccatgctg gcccactccc
    15061 ctcgatgagg cccgcgccag ggtggtgagc gcgtcggagg atgcgctcga gcgacatgtg
    15121 gcggcgcttc ggcgggcgct gtcgcggctt gttggtgaga ccccttgccc cgaagccact
    15181 tgaaggagaa ccagaatgag cgtcgaacaa caggtcagga ccgtgctcca cctgcttact
    15241 gggaacgccc cgcgatcggc atcgggtccg ggggggcccg gcaacttcgc ccccgccgcc
    15301 cgggccatgg tggcggccac gggaggattt cagtcccctg gccccagccc ggtggagacg
    15361 ccggactgga tgaccgactc ctgcatccag gctcttgggc tgggcgagaa ggaaacctgc
    15421 ggggtcatgg ggagcgacgt cgcactgaag gtctatgtcg agaagaagtt gcccaaatcc
    15481 aggctcggca aacccgtgcc caaggtcgtg tccctggacg gcatggcgcc catcctcacc
    15541 gacgtggtgg agatcgggaa ggtccggctg caaagcaata cgcagcggat ccgcccggcg
    15601 ctgcccggct tctcggtgag ccgcgctgaa gacccaccga acaccggcac ctttggcctg
    15661 gtggtgcgca agaaggggca ggcctcgccg ttctacctgc tcagcaactg ccacgccatc
    15721 gcggcctccg gtctggccaa caagggcgac atcatcatcc agcccggcgc ggcggacgag
    15781 ggcgtggcca cggcggatcg aatcggggcc ctctccgagt gggtgccgtt cgacttcact
    15841 ccgaacagca cccagaacaa catcgacgcg gccatcgccc agttggatga caatgtcgcc
    15901 agcgcggcga tcgcgttgct cggcgtcccc accggtgtga acacgaccct gacccggggg
    15961 atgtacgtgc agaaggtcgg gcgaaccacc agcctcagcg tggcccgcat caccgatgtc
    16021 gacctcgtgt tgaacctgtc ctatcccacc gcgtcgggtc tacagctggc cacgatgcgc
    16081 gaccaggtgc tggtgacctt ctattccaat ccaggtgata gtggttccag cgtgctcgac
    16141 atggacaaca aagtcgtggg gttgcatgtg gctggttcca gcgtcgtcgg gatcttctgc
    16201 aagattggca acgtcctgga gcgcctcggt ctcgaggtgg tgacccagga caatctgggg
    16261 actccggtca ccaccggctg aggggagggc accatggcca gcgaacagga ggcaaggcgg
    16321 ttgttgtccg ccgtttccgg gcacctgacg gccctgccga acgtcatcgg cgtcggcgtc
    16381 gtgccggccg agggcaagag ctccgaggcc tgcatcgccg tctatgtccg gtcgaaggtc
    16441 cccaaggcgg cgctcaagcc cgaggagctc gtgccagaga cggtgaaagg tcaggtcgat
    16501 ggtgtgtcgc tccaggcgcc gacccgggtg atcgaggtcg gcgacctcag gttttgagcc
    16561 cggcgcggct ggccagccac gtgcgcagcc gcgccaggaa ctcgggtgcc acgggccgag
    16621 gctcgaagta ctccgccaga ctggactgcc cacgggtgcg cttgaagagg tggtccaggc
    16681 cgggaaacag ggcataggtg cagtcccgcc cggagcggca cgccgccgcc agcaggcgtt
    16741 cggcatcccg ttcgggcgag acctggaagt cctcgccgcc ctggcacagc agcatgggac
    16801 agcggacctt gccaatcagc tcactcgtcg gatggcggag gaactcctcg taccaggtcc
    16861 gggtccggaa ggtggccagg aggtggtgcg ggagctgctc cgcgtcccag gggctcccgg
    16921 agcggatcag ctccgccacc ttgcgggtgt cggcttgctg ggcttcgatt tgcgcctcgc
    16981 tgaggcccaa ccgctggcca tgggcgagga tctgatcggc caacacctcg tccaggtcgc
    17041 gccccatcgc cgccatcagc accaccccgc gtaccccggg ctcgctcgac gactcgcccg
    17101 ccagcaccat cgcgatcgtc gcgccctggc tgtggccgat caggaagagc ggctggcccg
    17161 cggcctccgg gcgggcggac aggtaggcaa ggcaggcgcg ggcatcggtg atgtcggcgc
    17221 caaggccgcg gtcaagaaag tcggcaccga gccccgtggt gccggcaccg cgggtgtcga
    17281 agcgcagacc gacgaagccg tgcgcggcga ggtcgtccat cacctcgtgg ctgccgagat
    17341 cgatctcgcc agcgatgccg tggcggtcat gggtaccgga gccgctgatg aacaagacgg
    17401 cggggaaggg tcccttgccc ggcggtatcg agagggtggc cccgaggggc gtcacgggtc
    17461 cggcgatctc cacgtcctcc agccggaagc gggcgctctg gggcgggcgg taggcgaggg
    17521 gcggcgcccc gggtaccagc gggtccggcc aatcgggcac ggggggtccc tggcggatca
    17581 acgtggcgct gaagccggag tcgggactcc gcgcctccag catcaccccc gactcgtcca
    17641 gcaggacctc ggtccggtgg gaggtccgat gccagcggcc ggaggatgcc accagatctt
    17701 cggccggcga ggtctcgtag ggaaccgtga cgagcgtatt ggcgacgaac agtttcagct
    17761 tcaggtgctc gaccgggggc ggggcggccc ctcccgacat ggccgcgtag atcagtgcca
    17821 gggtagccgg gaagttgccg tccgagagga aggtggcgcc cgcgcggtcc aagctctggg
    17881 tggagccgtc cgggagcagg acgtccacct ggttcgcgga gaagcgcagt tgcaggcgga
    17941 cattgtcacc ttgcaggctg tagcgcaccg gttccagcgc cggggtacac cacagttcgc
    18001 cacggaggcg gagcttggcg ccaccgctgc ccatcgccgc cgggtcgacc tcggccagga
    18061 aggtcaggcg gtgcaactcc ccctgctcct ctccatggta ggtcgtccat tgttcgacgc
    18121 acacccggtc gagcatcgtc acccggtaga acagcgtcgg ctgcccggcg aaaagcaggc
    18181 gggcccagga cggcatcatg ctggagcgcc cttcaatgtc ctcaggcaac ccgccagatc
    18241 ctctggtgcg atcaacagcg cgtagccttc cgaggtgggg atgtagagcg cttcctcgcc
    18301 gcggccgagg aagaccaggg ccttctcgcc attctgcagg cggaaccatc ctgcccggta
    18361 gccaggcagc ccgactccca tggtgcgcca cttcggcgcc aggtccgggg attcacgcag
    18421 gttgacgatc cgcgctgact ccagccggag cgccgcggcc ggtatctctc gaccgaacgg
    18481 actgccccgg atacgcagcc cttcgttgga gatctcgaac tttggagccc gcagggcgag
    18541 cagcaacacc acgagcacga gtagcaacgt gacgaatatg acccacagca cgccgcgaga
    18601 gccgtggggt gccatctggt agacgtgcat caggatcctc cacgcggctg gccgccgcca
    18661 aggggggcgc ccgctgcggg atgcgtgcca gcggccacca gaaggaatgc cagctcctgc
    18721 caaaccgcct actgcttagt agtgcgacga cctcgcgtca tcaacccttc ggccattgag
    18781 gccttgagtg cacgacattt ggggatgggg gtgagtcgag ccgccggcct gagcggtgcc
    18841 cttggggttg ttccgtccag aaccgggcgg cttaccgcga ggctctttct gggcgcggtg
    18901 ctctgacggt ctgggggttg ccggacgatg ctggacggac ggtggccggg cctgcccgat
    18961 tcggtggctt tcccgcactt tgtgtggttc atgggcgtgg aagcagggaa gacgggactt
    19021 gtgtgccgtg cccaggtgct ccaccggccc acgagcagtc cgagcaggca ggccagcacg
    19081 gcctgtcgct gatgggggcg gtggaggggt tcgtgacgcg gatgccgttc gcgctgcgcg
    19141 cgcacgaacc cggaggatgt ggagccgttc ttcgaactcc tcgaggtccg actgcgcacg
    19201 ggccgtaccg gagcgcgctg gcagctcgat acccttgtgc ggctcgagtg tcggcctggc
    19261 ctgcccgagt ttggtagata gaggctgcgc gacgcggagt catcaagaga acttcgaggg
    19321 cgacaacgga ggctgccaag gaaatgagat ggatgaccct gacaactgcc ctggtactgg
    19381 ccagctcggg atgtgcccac tctcaacggc cagaatcccg aatccatgtt gtctccgaac
    19441 agtcagaggg agtcggctcc gcgctcggaa gtggtggttc tggtggctat gattgtaacg
    19501 atgaattcaa aaaatgcatg aaggtatgct gggataaacg ctatccgtgg ccacacaaca
    19561 agaggcagag cggctggtat cacgagcgct gtgagcagga ttgtaataga gcgttcaatg
    19621 agtatgagga cgagaagaag aaggaggagg agaggcaagg taaattgacg ttctcgcaca
    19681 tggacgaggc gattgattgg atcaagaatc acaaggccga ggtgatgatt ggaactgtcg
    19741 tcatcgtcgc tggcgttgca ttcgttctct caacaggtgg ttatggcact ttgattttgg
    19801 ctcctcttgc cctctgattt ggatgaaaat gatatataac aaagattttg atgttgactc
    19861 tgttctcgag atccttcgcg tcatagacga aaagtaccag gaaggctcgc cagaagacga
    19921 agcgctccga atcgccgcag tggcgttgtt ctacgtccga gagagccaga agataaacga
    19981 ttatcgtgag ttcttccgga agttctatac gcctgctgct gactacatag tgccttctca
    20041 tgagttcgca acgagagagg aggctgatga gtggctcgcc agtgggaatg ccaccgaggg
    20101 tgaactcgtc aagatagctg gcgaggggtt cagggtgatc ccgttgcgag atgcgaaggg
    20161 gttgaggttt cgtccgacac cccttccgga agagctagat aaaatgaatc ctcccggctc
    20221 cgagtaggca ctaggtcatt cgccagcttc ggacgcgttc aaccggtggt ttcgggcgat
    20281 gagcgtgcgc aggcgctcgg cgacctcgtc cgcggagagg gcgtccgtga agtggtcgac
    20341 gcagactcct tccgggtcga tcacgtaggt gatggccgtg tgcggcacgg cgtagccatt
    20401 gggatcctcg ggatcgtccc ggcgtcgggc gaagacgtgg aaggccgcct tggccgcttc
    20461 gatctgctcg cggctgccgg tcagaccgag gaaccccggc cagcgcgcga ggaacgcctt
    20521 catgaccgac gggtgatccc gctccggatc gaccgtgatg tacaggggct gcattcgcgc
    20581 ggcgtcgggg ccgagcaatc cgagcaccgt ggagaggcgt cccagggccc gtgggcagac
    20641 gacacggcag tgggtgaagc cgaagaacac cagggcgtag gctccacgga aggtctcgtg
    20701 ggtgacggga cgcccgtcgt gatcgacgag gtcgaaggcc ccacccaccg ggagcgcgga
    20761 acctggccgg agggtactca tgccccacct cccggccagg acagggtgta ggtgctgagt
    20821 tcgttgcgct ccagatgcag gtcgagcagg tgctcggtgc gccgtgcctc cacgcgccgc
    20881 ccctcatgca cttgttgccc atctcccgtg gcgaccacct ggccatccct ctggagttcc
    20941 cagctccccc ggtcccagat gttggccagg cggaggacgg aatcgccggg gcgattctcg
    21001 cgcacgccgg ccgtgaagtg cagcgtcgct cgcgcgtcgt cgtagtacgc ccggtggacc
    21061 tcgatggcgt cgccgacgat cgccaggttc ggttcggcga aatgacccgg cgcccagggc
    21121 tgctcgtaga gctgacgcag tccgtgcggc acgttcaggc tcgcgtacgc gaagaggaca
    21181 ttgccagtca ggggctcgac gcacgtgtag ttcccttccg cgtcgctcac ctcgtcatgg
    21241 cgcgggaaga agcggccgcc ctcatacacg gtgggtcgca tgtggcgctc cgcgtgacgc
    21301 tgtagcccct cgagcgtcgt ggcatccccc atctcggagg cccagaccgt cagccagcca
    21361 aaatcacagg tgtcgttctc gatggggcgc gcgccgaacg tccggggctt cggaggcctg
    21421 atggtgcgcg tgccatccgg accctcgagc acgtgcttgc cgagcacgga ggcgtagtac
    21481 ttctccacga actcgccgtt ccaggtgttc gcgagcgagg cgtaccaggc atcgccccac
    21541 ggcagctcgc ccgcgttggg cacgggcgtc ctcgtgtccg aggccgcgta gaggtacagg
    21601 tggccgttgt tggcgacggg tccgccgaac tgctcccacg cctgccggaa gccgcggctc
    21661 acctcgtccg cggtggagcc gcccttcaac agatcgtgca tccggaagcc gatgatcgcc
    21721 ggctggttgc agatctggaa gacgcagttc ggctcgcacg cgatccccag gtacccgttg
    21781 cgcaccatct gccagtacag gttttcgttc agcgagaact ggtcgtattc gaacttccgg
    21841 tcgagacccc ccggcttgcc accgtcgccc cagaatgggg tgaagtactc cagcgtcagc
    21901 gagccgggcg cggcgtagcg cgcgtcgtcg aacagcacgt tgtacatgag cgccatcgac
    21961 tgcacgtagg cgctgtacat gatgttgtcg tgcgccactg gatcccactg ctcgggacgg
    22021 cccgcgaggt gtgggttcca gatgccgccg gccttgctcg agtcgcgcca gtacatccag
    22081 acctcgggct cgaggatctt ggagatcaac cgctggaacg tgggccggag ggcaccgggc
    22141 gccgctggca gccgatggac atgggtcagc
//
