LOCUS       NZ_CP022098            22163 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3148744
            Orig. end                         :: 3170907
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="14"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12163](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12163)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(684..1169)
                     /locus_tag="CYFUS_RS13060"
                     /old_locus_tag="CYFUS_002585"
     CDS             complement(684..1169)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012472.4"
                     /locus_tag="CYFUS_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002585"
                     /product="aldo/keto reductase"
                     /protein_id="WP_232537537.1"
                     /transl_table=11
                     /translation="MGSVRPTAFEYSLFTRKPEQNVFPVLSELGIGVTAYGVLAHGLFS
                     GKAKSAEKGGHRSHLPWFHPGNFEQNMKLVDALAAIAAENQVTASQMAIAWALAKRTDL
                     VPVVGARTMEQLESTLAALRLQLSAEDVARIEAAVPPEAVAGTRYLPQLMKMLDSER"
     gene            complement(<1207..1413)
                     /locus_tag="CYFUS_RS52635"
                     /pseudo=""
     CDS             complement(<1207..1413)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012472.4"
                     /locus_tag="CYFUS_RS52635"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEPLMTTPSRTLGDNGPSVFPIALGSEALTHGDGLRLIHEAIDRG
                     VDLIDTADFYGAGGDEMLIGKALE"
     misc_feature    complement(1414..1432)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    1417..1435
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.32"
                     /tool="antismash"
     gene            1476..2057
                     /locus_tag="CYFUS_RS13065"
                     /old_locus_tag="CYFUS_002586"
     CDS             1476..2057
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037152.4"
                     /locus_tag="CYFUS_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002586"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_095985514.1"
                     /transl_table=11
                     /translation="MPRTGLSAAELRTKAIDVALEHIRAHGFEKVRLTDVARELGVSHV
                     ALYAHFANKEALLDAVLERWLEETSVALEKVCASNRKPAQKLEQWFVNQYAMKRDRALH
                     DRATYSAFETATAAKKPFVKAYLARRSAQLVGLLDEAGFGSPQRHAEVLLDGMAGFFHP
                     RLILESAEQNREPELKRVLQTLLRGLERGA"
     gene            complement(2231..3307)
                     /locus_tag="CYFUS_RS13070"
                     /old_locus_tag="CYFUS_002587"
     CDS             complement(2231..3307)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017532.4"
                     /locus_tag="CYFUS_RS13070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002587"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_157758416.1"
                     /sec_met_domain="PhyH (E-value: 1.9e-18, bitscore: 66.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDAVPRNLEEALPLVKGMVPEFLRERIPPTVKERIRSMMGVPGP
                     GVKPVVEDDSTPVTEFLSARGIQLRQLKAYRQENFPHDGPKMWLDTPDAERRIDDKLRA
                     GLITAGEAEMCRKFSRDGYVVVEKLFDDAFLDRLWAAFLRDIQSGRVPLEPEKPGEDRS
                     EWGRVLNIHNYVPEMAELLFHERLKQRISLLVGREAIPFQTIPSFRGSEQLPHSDAIHM
                     TTYPLGFLSAAWVAFEDIHPDSGPLVYYPGSHRLPYFLSKETGIGPTEYKEQGRNPYTN
                     KYEPFIQKKIDELGLKPAYFTPKKGDVLIWHHNLLHGGSRRRERSHTRKSVVCHFYASN
                     VICYHDLSGDPAGVGVRA"
     misc_feature    3437..3448
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            3603..3878
                     /locus_tag="CYFUS_RS13075"
                     /old_locus_tag="CYFUS_002588"
     CDS             3603..3878
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002588"
                     /product="hypothetical protein"
                     /protein_id="WP_095985516.1"
                     /transl_table=11
                     /translation="MLVPVTYSFTSVGSYVLNLTSPAGTQALVGIPRKQPWTSVSVNGV
                     TVWREVQFVDGAAGVSQAGADSAYIKFLSWLCLRLKGSPGQVILTV"
     gene            4000..5058
                     /locus_tag="CYFUS_RS13080"
                     /old_locus_tag="CYFUS_002589"
     CDS             4000..5058
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002589"
                     /product="hypothetical protein"
                     /protein_id="WP_095985517.1"
                     /transl_table=11
                     /translation="MWKFFLLILMAWLSGIPGAGGLVLLVMFFLYLAYSIRYRGYYGRL
                     SKEETKSLRLASAVDNNGMRSQWDVIPWPGTSKHVIRKWTWDRIALDTTIQNAMSEASK
                     ALTHASGELSKWIGEKAAGSSINPYSGTLAVIDQEHQKSHNPKTALALLHRVSSGYESW
                     TNQAICTLGGTFIICAEAYKGEVKTAFQGKKKQEPRMKSGTVAETSRLTWKMGQLFLNP
                     GTASIANFLNAVFARINPWDKHAIVTYKEKEYYAPTTMFGASATIMKVMNLCEALGLSD
                     EQKVFVGYSVAMHWIDKYLNDNSWFLGGMFTPDRHSLIEALQGMYAHIENDPRKAAAVL
                     VEMYEKADEARK"
     gene            5178..6506
                     /locus_tag="CYFUS_RS13085"
                     /old_locus_tag="CYFUS_002590"
     CDS             5178..6506
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002590"
                     /product="hypothetical protein"
                     /protein_id="WP_095985518.1"
                     /transl_table=11
                     /translation="MTSFRRPSTYHLVLALLAGTAGIACGSEPIPDSGPLSTLPDVCPS
                     GLVADNRYPLIQDSPYAADYRLRVFGQVDFQGQTYKVVNALPWDYLASHVQAGKTFPVT
                     ETPSYYVVDSNFELPYLPCLMDEVAWTPGNKNKGWAIGSNDDPAALVAKNGAGRPFLYH
                     VVTDNEYGYFTYTEPLPGDPIRYSGFRPTWVVHEEGALHPMYYLDPARPDRHGFSWPRH
                     GDKWELNFGLFVDSAGKVYVPKKAPLAVPQWDTYLECVVINMANAPIPTTRTQFPGNES
                     YYAADTFIPGYAAPPAVGHRYWGQKGREMSEVAVWEDDGGPGLPSPGNYHKPYSGGCDT
                     KGYNFAHAEGFTWPELRAYRTAHGDAVTRDQLYSITVYKVARDGTARLLGTLSYEQQAN
                     GEWIPTGSGPEAHSLNDRNGRWIINGPIFPDRGERAVAVLRNL"
     gene            complement(6563..7171)
                     /locus_tag="CYFUS_RS13090"
                     /old_locus_tag="CYFUS_002591"
     CDS             complement(6563..7171)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002591"
                     /product="hypothetical protein"
                     /protein_id="WP_157758417.1"
                     /transl_table=11
                     /translation="MTKPSEFPAPPPSLNELRERVHALDLMALGEPYASELSAEGRKIL
                     QGVSPKPIGRDDNDAPEADKAWSWGPLIGAVAIAWSVAEVLHPVVSLGTETLSKDGFKT
                     MFVAVLGAGLTLFAPGLLLSQRWLGPVTRSVFVVLTLLTSLAMGGIGLFVALFVSFADW
                     TSTSDGQFALMMLAGALVRFGLVGGLVAEEFAPEPPEPE"
     gene            complement(7227..8051)
                     /locus_tag="CYFUS_RS13095"
                     /old_locus_tag="CYFUS_002592"
     CDS             complement(7227..8051)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012745.4"
                     /locus_tag="CYFUS_RS13095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002592"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_095985520.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.6e-14,
                     bitscore: 53.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGPDNPRVLLSAAVMTKDSLRTLPECLDSLDFCDEIVVVDDHST
                     DGTWEYLQSRGAKVRAFQRKLDTFASHRRAMCAQARGEWVLIVDADEKALPGLGEEIRA
                     LLGRGSPRHDAYHVPQKNTLPDHWPRPVYFWTSQKRLLRLAKVRWEDSEWIHVPALHEG
                     KAGRLEHGLSHRSYDSVSHLLRKQISYAQSGAKHFHARGRRASLASAVSHTVGAFFKFY
                     LLKGLCRFGMGGLTVATALAFHVFAKYALLWEMNSGRASAGERARVPGDTHV"
     misc_feature    complement(8054..8063)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(8185..10038)
                     /locus_tag="CYFUS_RS13100"
                     /old_locus_tag="CYFUS_002593"
     CDS             complement(8185..10038)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631949.1"
                     /locus_tag="CYFUS_RS13100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002593"
                     /product="S9 family peptidase"
                     /protein_id="WP_095985521.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.3e-44, bitscore:
                     150.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNETRASSPRRAESFSAAQAVAAATDFAELRVGPAGLYYNEFRPQ
                     DARCRIWRWRDGDEPRCLTPEGFSVRSRVYEYGGGSFCLGPDWLVFVNEADQQLYRQPL
                     DGGDPVALTRGERRHGDLRQGRGVVLAVEETHAEGAVEHRLVAIGLEGGERLVLAEGAD
                     FYAAPVQSADGERLAWIEWQCPQQPWTRTRLCTLRRQADGGYGDPRCVAGDGEQAESLQ
                     QPRFSADGRLGCLSDRNGYWQPWMETAEGWAALPAMPADHAPAPWQGSASTWAPLDGER
                     YLATWFEDGFGRLGLCEKEDRPRDFSCGYTRFRGLDLDTRYFYAIVASPMSAPAVLAID
                     RQTCNAQVIAGGESPLPAECISRPRPIHYPCGGETAHGFFYPACSEDSRPPLVVFIHGG
                     PTSACYPVLDTRIQYWTQRGFAVADLNYRGSSNHGRAYREKLHEQWGVVDVEDACAVVG
                     YLAEQGLVDGGKAFIRGGSAGGYTTLCALTFHEVFRGGASLYGVSDPLALGRVTHKFEG
                     DYLDWLIGDPERDAERYRARTPLLHADRIEVPVIFFQGELDAVVVPQQSRDMLQALQSR
                     GVQAEGHFYPRERHGFRQAANLAHALDAEWRFYRHILDASR"
     gene            complement(10001..11164)
                     /gene="pqqE"
                     /locus_tag="CYFUS_RS13105"
                     /old_locus_tag="CYFUS_002594"
     CDS             complement(10001..11164)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631950.1"
                     /locus_tag="CYFUS_RS13105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002594"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_095985522.1"
                     /sec_met_domain="PF04055 (E-value: 2.4e-22, bitscore: 79.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.3e-06, bitscore: 26.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.9e-09, bitscore: 36.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-07, bitscore:
                     31.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNTGSNLAEVPPKPAVGLPLWLLAELTYRCPLQCPYCSNPLDFA
                     AQGKELTTEEWFSVLRQGREMGAAQLGFSGGEPLVRQDLAELIGEARRLGYYTNLITSG
                     MGLTEQKIRAFKDAGLDHIQISFQASDAQVNNMLAGSKKAFDQKLEMARMVKAHGYPMV
                     LNFVTHRHNIDKIDRIIELCVALEADFVELATCQFYGWAQLNRVGLLPTREQLERAERI
                     TNDYRARLAAEGKPVKLIFVTPDYYEERPKACMNGWGSLFLTVTPDGTALPCHSARQLP
                     VKFPNVRDHSLHHIWYDSFGFNRFRGYEWMPEPCRSCNEKEKDFGGCRCQAFMLTGDAS
                     NTDPVCGKSPRHDLILKAREEARTATAAIGELTFRNERNSRLITKKG"
     gene            complement(11136..11411)
                     /gene="pqqD"
                     /locus_tag="CYFUS_RS13110"
                     /old_locus_tag="CYFUS_002595"
     CDS             complement(11136..11411)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631951.1"
                     /locus_tag="CYFUS_RS13110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002595"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_095985523.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.4e-33, bitscore:
                     111.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.6e-15, bitscore: 54.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFDRNLTPRWRQGYRFQYEPAQKAHVLLYPEGMIKLNESAAAIG
                     GLIDGVRSVQTIINALDQRYPGVPELGEDVEQFMEVARAQHWIELG"
     aSDomain        complement(11142..11408)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CYFUS_RS13110_PqqD_RRE.1"
                     /evalue="1.80E-35"
                     /identifier="RREFam006.1"
                     /label="CYFUS_RS13110"
                     /locus_tag="CYFUS_RS13110"
                     /protein_end="90"
                     /protein_start="1"
                     /score="111.6"
                     /tool="antismash"
                     /translation="SFDRNLTPRWRQGYRFQYEPAQKAHVLLYPEGMIKLNESAAAIGG
                     LIDGVRSVQTIINALDQRYPGVPELGEDVEQFMEVARAQHWIEL"
     gene            complement(11408..12163)
                     /gene="pqqC"
                     /locus_tag="CYFUS_RS13115"
                     /old_locus_tag="CYFUS_002596"
     CDS             complement(11408..12163)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631953.1"
                     /locus_tag="CYFUS_RS13115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002596"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_095985524.1"
                     /sec_met_domain="TIGR02111 (E-value: 9.3e-126, bitscore:
                     417.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTPLTRAEFEQALRAKGAYYHIHHPYHVAMYEGRATREQIQG
                     WVANRFYYQVNIPMKDAAILANCPDREIRREWIQRLLDHDGAPGEDGGIEAWLRLGQAV
                     GLDPDQMRSQELVLPGVRFAVDAYVNFARRASWQEAASSSLTELFAPQIHQSRLDSWPR
                     HYPWIDPSGYEYFRTRLGQARRDVEHGLAITLAHYTTYEGQQRMLEILQFKLDILWTML
                     DAMSMAYELNRPPYHTVTNQRAWHKGIAL"
     gene            complement(12172..13083)
                     /gene="pqqB"
                     /locus_tag="CYFUS_RS13120"
                     /old_locus_tag="CYFUS_002597"
     CDS             complement(12172..13083)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019097150.1"
                     /locus_tag="CYFUS_RS13120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002597"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_095985525.1"
                     /transl_table=11
                     /translation="MYIQILGSAAGGGFPQWNCNCANCKGYRDGTLRAKARTQSSIALS
                     DDGVHWILCNASPDIRAQLQSFAPMQPARALRDTGINAIILLDSQIDHTTGLLSLREGC
                     PHQVWCTDMVHQDLTTGFPLFKMLSHWNGGLQWNRIGLEGSFTIEACPNLKFTPFPLRS
                     AAPPYSPHRFDPHPGDNLGLVVEDPRTGGKLFYAPGLYQVDAALKQHMADADCLLVDGT
                     LWSDDEMQRRGVGTRTGREMGHLCQNGPGGMLELLDGFEKPRKVLIHINNTNPILDEDS
                     PERAELERRGVEVAFDGMSIEL"
     gene            complement(13153..13224)
                     /gene="pqqA"
                     /locus_tag="CYFUS_RS13125"
     CDS             complement(13153..13224)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008365141.1"
                     /locus_tag="CYFUS_RS13125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_076606242.1"
                     /transl_table=11
                     /translation="MWTKPAYTDLRIGFEVTMYASNR"
     gene            complement(13379..15847)
                     /gene="pqqF"
                     /locus_tag="CYFUS_RS13130"
                     /old_locus_tag="CYFUS_002598"
     CDS             complement(13379..15847)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR02110.1"
                     /locus_tag="CYFUS_RS13130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002598"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqF"
                     /protein_id="WP_095985526.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 1.5e-31, bitscore:
                     108.5, seeds: 24, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M16_C (E-value: 3.5e-06,
                     bitscore: 26.3, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESSDQGRESLVLAHGLRVRLRHEPRLRRAAAWLRVEAGSHDVD
                     AQWPGLAHFLEHLVFLGTERFPREQGLMAFVQHHGGQVNARTSERTTDYFFELPQAVFG
                     EGLERLCDMLARPRLAIEDQQREREVLHAEFIAWSRDTQAQHLFCLAGGVSARHPLRAF
                     HAGNRDSLPVASPEFQQALHDFHRRYYRTGQMTLQLVGPQPPRILAGLATDADAALAAG
                     PRNANAPVETLLGDPGEPPPTSDPRRLNLLFACDGLPPGTDEALRFLEPWAGSAHPGGL
                     LAELRRLGWAQSLSLSPLYQYADQALVNFEVQLTEAGQQSRAEAQTLCFDWLKYFQSHA
                     GWEPLREEYRLLRSRQSQTEGALELARRLAHGESSELPDEAVPALRALLERFTPQALLA
                     PGAQALDEPPLLPPFGPWRLPPRNRFLRGQHRPTQAGPRIAALEQGELEPNRGLEGGVH
                     LRWRLANRHHAALWHMLDASLRRLGEEARQAGVQLEFSRLGLDWQLRLYGVREPIPAIL
                     EQAEELLQRPTPESWHQASPPPRQQVPIRELLAQWPEHALGHHRPARNDSSELHPEALQ
                     RLWQQARWDGLVLGFDEADRLALDAVAARLPGSASNDLRQPSTLPGRANWSQVTCGSDE
                     HALLVWCPAPSVSIEDEAAWRALAQLIQVPFYQRLRTELQLGYAVFSAFRQLAGRPGLL
                     FGVQSPGSDCAALWGHIAEFLDALPERLAQWPGTRLREQCAALADSLDGGNLGLAQRLE
                     MQWQARLTDPSSDYSNTLRLRESAKLRESVGQLDGSTLVEAAHRLLASQVSWTALATGP
                     CPGASWYEAV"
     gene            complement(15994..16725)
                     /locus_tag="CYFUS_RS13135"
                     /old_locus_tag="CYFUS_002599"
     CDS             complement(15994..16725)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002599"
                     /product="hypothetical protein"
                     /protein_id="WP_095985527.1"
                     /transl_table=11
                     /translation="MKALALALLLLCSPALAATPRNALLDVSADVLEPGESQIDLFFGQ
                     LAFGVLPRVQLSSQIAPYLITLLNLSAKVQVLDRPELRVSVEGGAYWLAIGRLVDANVL
                     SIPVAVRGTVPLSDNLNLHLGAGYHRFAFDFAGTSTDSNALHVETTLARHDSRGAFLLT
                     AKAPLLNIQHARSQSGIDNRPLEGSLALDGISSWSVMLARDHLFGKTGHVRFGIGYRHR
                     PGILLVESIGPVVVNFNLYWR"
     gene            complement(16722..17243)
                     /locus_tag="CYFUS_RS13140"
                     /old_locus_tag="CYFUS_002600"
     CDS             complement(16722..17243)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002600"
                     /product="hypothetical protein"
                     /protein_id="WP_095985528.1"
                     /transl_table=11
                     /translation="MSRWFLLGGVLLAGQAGAVPLRAGVDVALLLRQEAPGHRTGLLSG
                     GPRVVFELGRYLALSGDYRFAWSSEGTLAHVVTRYHRFSVRPELHLPVRTTDFVIAAGP
                     ALTVFHSSLGGGGTHVSTTAARLGISGGAAVDIHLEPLTLRTGMDLVWAAQRLDVSVGI
                     GALFTFGEEP"
     gene            complement(17240..18370)
                     /locus_tag="CYFUS_RS13145"
                     /old_locus_tag="CYFUS_002601"
     CDS             complement(17240..18370)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS13145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_002601"
                     /product="hypothetical protein"
                     /protein_id="WP_157758418.1"
                     /transl_table=11
                     /translation="MKNTNRVETFRARRRWRSLLGPVLLGLGMQGCAPEDASGTVMAYV
                     FARDETTGRYALGRHPVENLESLRGLRGRDVDFRMGSELTPSSYERGSPFALEYTREAD
                     GTLVPADMHSLYALSLYRSMDRTATLLRAHGHVPRRRLDVLYYPRLDNILIGDGRAELT
                     DNAAYFSVGPSFLIVPSFLLDGLPMMLNEGVVAHEFGHAVIHQEMFGDLESIPGEGDAS
                     WDITRRDLSAMHEGVADLFGLIVTGDPDYVLATVDADRDMAEPRDYTSRQRQEALLGEG
                     FEPHAHGSLLARAVHELWPKDDQGRISPEGRSRLLTATLATLRELKFEKDTFTLASFPN
                     TLVTHLSAGEREAACAVLLKRMEPLASTLTACEVTP"
     misc_feature    18384..18398
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            complement(18442..19170)
                     /locus_tag="CYFUS_RS13150"
                     /old_locus_tag="CYFUS_002602"
     CDS             complement(18442..19170)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-152). E-value: 3.8e-14. Score:
                     44.9. Matches aSDomain:
                     nrpspksdomains_CYFUS_RS13150_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002627944.1"
                     /locus_tag="CYFUS_RS13150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_002602"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_095985530.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1.2e-30, bitscore:
                     106.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSLKGKTAIITGGGSGIGFAIAERYTREGAQVVLAGRNQQRLDK
                     AVEKLGRAARGVVTDVADEAQVERLIDSVPRIDLLVTCAGGAVFGPVEQVPRKSWSELF
                     DARFFGQLSACHHAVPKMPPGSAIVLCSGVAGHAALVNYSGGAALCGAVNAMGRSLAVE
                     LAPKGIRVNVLSPGLTRGTDIDWQVPPEKLDAFMSSLMERIPLKRTATAREMADAAFFL
                     ATNAYATGVVLDIDGGWTAV"
     aSDomain        complement(18715..19149)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CYFUS_RS13150_PKS_KR.1"
                     /evalue="3.80E-14"
                     /label="CYFUS_RS13150_PKS_KR.1"
                     /locus_tag="CYFUS_RS13150"
                     /protein_end="152"
                     /protein_start="7"
                     /score="44.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAIITGGGSGIGFAIAERYTREGAQVVLAGRNQQRLDKAVEKLGR
                     AARGVVTDVADEAQVERLIDSVPRIDLLVTCAGGAVFGPVEQVPRKSWSELFDARFFGQ
                     LSACHHAVPKMPPGSAIVLCSGVAGHAALVNYSGGAALCGA"
     CDS_motif       complement(19054..19143)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CYFUS_RS13150_0001"
                     /evalue="2.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="CYFUS_RS13150"
                     /protein_end="39"
                     /protein_start="9"
                     /score="17.0"
                     /tool="antismash"
                     /translation="IITGGGSGIGFAIAERYTREGAQVVLAGRN"
     misc_feature    19197..19211
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.77"
                     /tool="antismash"
     misc_feature    complement(20798..20811)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(21059..21073)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.71"
                     /tool="antismash"
ORIGIN
        1 agccggtagg cgtagcgcgg cagcggcacg accgcacgct ggtacttgag ggcgagctgg
       61 accggctcgg tggcggccag gtcgacggcc tcggcgtccc ccagtgcgag cgccacctgc
      121 tccaggatgg agtcgtgaca cgcctgggcg gcctggacgt ctccggccgc gaagtcctgg
      181 tccgacgtcc gcaggcagtg ctcgggctgc gaggtggggg cgaggtccac ctccacgtgc
      241 tcgggcagat ccgtggcggc ggcaccatgg aggtcgttgt ctcggacccc ggccagcatc
      301 gccaccgtcc acgcgtcgcg agccgtcggc aggtggaagg gcaggttgtc cacgaggacc
      361 ttctgtccgg ccgtcggcgc gggaggcagc gctccgtccg gccagcccgc ccgcgccagc
      421 gcggcggcgg tgagccgctc gtggcagccc tccgtcaccg gcgtctcgat ggtgtacgcg
      481 cgggccgcgg ttgtaccgag gaggagggcg gccagcagcg tcgaagcagc cagcggaagg
      541 tagcggcgga gggagggcac gtgtggagac cgacggggcc tgactgtacc accgggcggg
      601 gattgggagg aattggcccc ggggcgcgag gtcacggctg ctcgcggagc aggccagggt
      661 gtcaccctgg aagacccgcc agattagcgc tcgctgtcga gcatcttcat caactgcggc
      721 aggtaccggg tcccggcgac cgcctcgggc ggaaccgccg cttcgatgcg cgcgacgtct
      781 tccgcgctca actgaaggcg cagggccgcg agcgtgctct cgagctgctc catggtccgc
      841 gcgccgacca ccggcaccag gtccgtccgt ttcgccaacg cccaggcgat ggccatctgc
      901 gacgcggtca cctggttctc cgcggcgatg gcggccagcg cgtcgaccag cttcatgttc
      961 tgctcgaaat tccccgggtg gaaccacggc agatgcgacc ggtgaccacc cttctccgcc
     1021 gacttcgcct tgccgctgaa caggccgtgc gcgagcacgc cgtaggccgt cacgccgatg
     1081 ccgagctcgc tcaacaccgg gaacacgttc tgctcgggct tgcgcgtgaa cagcgagtac
     1141 tcgaatgccg tcgggcgaac ggagcccacc gaacttcacc gacaacttca ccttgtcgcg
     1201 ccggccttcg agcgccttgc cgatcaacat ctcgtcacca ccggcgccgt agaaatcggc
     1261 ggtgtcgatg aggtccactc cgcgatcgat ggcttcgtgg atgagccgca gcccgtcacc
     1321 gtgggtcagc gcctccgagc cgagcgcgat gggaaaaacc gaagggccgt tgtcgccgag
     1381 cgttctggat ggggtcgtca tcagtggctc cattcgttac tgtttacaaa atacgtaagt
     1441 tgtaataaac cgctcgtcaa gggaatcgcc acgccatgcc ccgcaccgga ctttccgccg
     1501 ctgaactcag gaccaaggcc atcgacgtcg cgctcgaaca catccgcgcg cacgggttcg
     1561 agaaggtgcg gctcaccgac gtggcccggg agctcggcgt cagccacgtc gcgctctacg
     1621 cgcatttcgc gaacaaggaa gcgctgctcg acgcggtgct cgaacggtgg ctcgaggaga
     1681 cgagcgtcgc cctcgagaaa gtctgcgcgt cgaatcgcaa accggcgcag aagctcgagc
     1741 agtggttcgt gaaccaatac gcgatgaaac gcgatcgcgc gctccatgat cgcgccacct
     1801 attcggcgtt cgagacggcc accgcggcga agaagccgtt cgtgaaggcc tatctcgcgc
     1861 ggcggagcgc acagctcgtc ggtctgctcg acgaagccgg tttcggttca ccgcaacgcc
     1921 acgccgaggt gctgctcgac ggcatggccg gcttctttca tccccgcttg attctcgaga
     1981 gcgccgagca gaatcgcgag ccggagctca agcgggtgct gcagacgctc ctgcgcgggc
     2041 tcgaacgagg agcgtgagtt gctccagggc acctttgggc tgggctgagg ccctgctccc
     2101 cgaggtgggt gcgtgcgttg gtcagcgcac cgaggcgggg agctcttccg ccttgaggcg
     2161 gacccgaagg tcttgacgtc caactgtagt cgtaggccgc ccgcgcctca ccacgcgggc
     2221 gcggcctggc tcaggccctt accccgacac ccgctggatc gcccgagagg tcgtggtagc
     2281 agatgacgtt gctggcgtag aagtggcaca ccaccgactt gcgcgtgtgc gagcgctcgc
     2341 ggcgccgcga gccgccgtgg agcaggttgt ggtgccagat gaggacgtcg cccttcttcg
     2401 gggtgaagta ggcaggcttg agccccagct cgtcgatctt cttctggatg aagggctcgt
     2461 acttgttggt gtacgggttg cggccctgct ccttgtactc agttggcccg atgcccgtct
     2521 ccttcgagag gaagtagggc agccgatggc tccccgggta gtacaccagt ggccccgagt
     2581 ccgggtggat gtcctcgaag gcgacccagg ccgcggacaa gaagcccagc gggtaggtcg
     2641 tcatatggat ggcatctgag tgcggcagtt gctccgaacc ccggaacgag gggatggtct
     2701 ggaaggggat ggcctcgcgc cctaccaaca gggagatgcg ctgcttcagg cgctcgtgga
     2761 agagcagctc cgccatctcc ggcacgtagt tgtggatgtt gagcacgcgc ccccactcgg
     2821 agcggtcctc acccggcttc tccggctcca gtgggacgcg gcccgactgg atatcgcgca
     2881 ggaacgcggc ccaaagcctg tcgaggaacg cgtcatcgaa gagcttctcc acgacgacat
     2941 agccatcgcg tgagaacttg cggcacatct cggcttcccc ggcggtgatg aggccagcgc
     3001 gcagtttgtc gtcaatgcgc cgttcggcgt ccggcgtgtc gagccacatc ttcggcccgt
     3061 catgggggaa gttctcctgc cggtacgcct tgagctggcg gagctggatg ccccgggccg
     3121 agaggaactc ggtgacgggc gtcgaatcat cctccaccac gggcttcacg ccggggcctg
     3181 ggacgcccat catgctccgg attcgctcct tgacggtggg aggaatccgc tctcggagga
     3241 actcgggaac catacccttc acgagcggca gggcctcctc gaggttgcgc gggacagcgt
     3301 ctttcatggt cggggggatc cggtcgatga cgaagcgcgg aacgacgctc ttcagcaggc
     3361 tgagcgctgg aggaaggggg tgcttggagt tcatagttgt gggcacgcct cccggccgag
     3421 cgtgctggat tgaggggtaa aggaacgccg gccctggttt tgcccgagga cagggagaat
     3481 gtccacatat gggggattgg tacgggaaaa gactcacata ccagccgccg gcacatgccg
     3541 gtcctggcgg accatccggg acggaagaag cgagtcaggc gttctgcctc ccatcgaccg
     3601 tgatgctggt acccgtcacg tactcgttca cgtcggttgg cagctacgtg ctgaacctga
     3661 cgtcaccggc cggcacgcag gccctggtgg gaatccccag gaagcagccc tggacgtcgg
     3721 tcagcgtcaa cggtgtcacg gtgtggcgcg aggtgcagtt cgtggatggg gcagccgggg
     3781 tcagccaggc tggcgccgac agcgcgtaca tcaagttcct ctcctggctc tgcctccgtt
     3841 tgaagggttc ccctggacaa gttattttga cggtgtaatc atgaattcca atgagaatct
     3901 gaacgagcag aaggctgccc tgctcgagcg ggctaccggc ggctgacctt caacccattc
     3961 ccctcaggtt cagacggaac cagtacaagg agaagacaga tgtggaagtt cttcctcttg
     4021 atcctcatgg cctggctttc gggcattccc ggagcaggcg gcctcgtgct cctcgtgatg
     4081 ttcttcctct atctggcgta ttcaatcaga tacagaggct attacggcag actgtccaag
     4141 gaggagacga agtcacttcg cctcgcatcc gctgtcgata ataatggcat gcgctcccaa
     4201 tgggacgtca ttccgtggcc gggaacttcc aaacacgtca ttcgcaagtg gacttgggac
     4261 agaatcgcac tggacacgac gattcagaac gccatgagtg aagcgtcaaa ggcgctcacg
     4321 catgcctccg gcgaactttc caagtggata ggcgagaaag ctgcgggctc atcgataaac
     4381 ccctacagcg ggacgttggc ggtgatcgac caggagcacc agaagtccca taacccgaag
     4441 acggcgctcg ctcttctaca cagggtatct tcgggatatg agtcctggac caaccaggcc
     4501 atctgcacgc tgggcggcac cttcatcatt tgcgctgagg cgtacaaggg cgaggtcaag
     4561 actgctttcc aaggcaagaa aaagcaggag ccgcgcatga agtccggcac ggttgccgaa
     4621 acgtctcggc tcacctggaa aatgggtcag ctcttcctga atcctggcac cgcctccatc
     4681 gccaatttcc tgaatgccgt cttcgcacgg atcaatccgt gggataagca cgccatcgtc
     4741 acgtacaagg agaaggagta ctacgcgccg acaacgatgt ttggtgcctc cgcgaccatc
     4801 atgaaggtga tgaatctctg cgaagccctg ggcttgagcg acgaacagaa ggtattcgtt
     4861 ggttatagcg tggccatgca ctggatcgac aagtacctga acgacaactc gtggttcctt
     4921 ggggggatgt ttacccctga tcgccactcc ttgattgagg cgctgcaagg tatgtacgct
     4981 cacatcgaga atgacccgcg caaggctgcc gctgtgctgg tagagatgta tgaaaaagca
     5041 gacgaagcga ggaagtaagc tcctcttttg ctacgtggga aggccctggc aggggatggc
     5101 tccgtcactc accatggcca acgcgggccg ctccagaacg cgctttctcc ctgttttctg
     5161 tcgatgtacg gtttgccatg acctcattcc gtagaccatc cacgtaccac ctcgtactcg
     5221 cgctgctcgc cgggaccgcg ggcatcgcat gcggctccga gccgatcccc gactccggcc
     5281 cgctgtccac gctccccgac gtctgcccga gtggcctcgt cgccgacaat cgctacccgc
     5341 tcatccagga cagcccctac gccgcggact atcggctccg cgtgttcggg caggtggatt
     5401 tccaggggca gacctacaag gtcgtgaacg ccctgccctg ggactacctc gcctcgcacg
     5461 tccaggcggg caagacgttc cccgtgaccg agacgccctc gtactacgtc gtcgacagca
     5521 atttcgagct gccgtacctg ccctgcctca tggacgaggt cgcctggacg ccgggaaaca
     5581 agaacaaggg ctgggccatc ggctcgaacg acgatcccgc cgccctggtc gcgaaaaacg
     5641 gcgccggccg acccttcctc taccacgtgg tcacggacaa cgagtacggg tacttcacgt
     5701 acaccgaacc gctcccaggt gatccgatcc gctactccgg gttccgtccg acatgggtcg
     5761 tccacgagga gggcgcgttg cacccgatgt actacctcga cccggccagg cccgaccgcc
     5821 atggcttctc ctggccacgg cacggcgaca agtgggagct gaacttcggg ctcttcgtcg
     5881 actccgccgg caaggtctac gtgcccaaga aggcgccgct ggccgtcccg cagtgggaca
     5941 cgtacctgga gtgcgtcgtc atcaacatgg ccaacgctcc cattccgacg acccgcacgc
     6001 agttccccgg caacgagtcg tattacgccg cggatacctt catcccgggg tacgccgcgc
     6061 cccccgctgt cggccaccgc tactggggac agaaggggcg cgagatgagc gaagtcgccg
     6121 tctgggagga cgatggtggg ccgggcctgc ccagcccggg caactaccac aagccctatt
     6181 ccggcgggtg cgatacgaaa ggctacaact tcgcgcacgc cgagggcttc acgtggccgg
     6241 agctccgcgc ctaccgcacc gcgcacggag acgccgtcac ccgggaccag ctctacagca
     6301 tcacggtcta caaggtcgcc agggacggaa ccgccaggct gctcgggacc ctctcctacg
     6361 agcagcaggc caatggcgag tggatcccca ccggctctgg cccagaagcc cactcgctca
     6421 acgaccgcaa cgggcgctgg atcatcaacg gcccgatctt cccggatcgc ggcgagcgcg
     6481 ccgtcgccgt gctgcgaaac ctctaatctt gcggtcgttg cagcggctca tcggcgaggt
     6541 gctgcgcgcc gcctgacagg actcactcgg gctcgggcgg ctcgggtgcg aactcctccg
     6601 cgaccaggcc gcccaccagg ccgaagcgca ccagcgcgcc cgccaacatc atcagcgcga
     6661 actgtccgtc gctcgtgctc gtccagtcag cgaaactgac gaagagcgcg acgaagaggc
     6721 caatgcctcc catggcgagg ctcgtcagca gggtgaggac gacgaacacg ctccgggtca
     6781 cgggcccgag ccaacgctgg ctcagcagca gtcccggcgc gaaaagggtg agacccgcgc
     6841 cgagcaccgc gacgaacatc gtcttgaagc cgtccttgga gagagtctcg gtgccgagcg
     6901 aaacgaccgg atggagcacc tcggcgacgc tccaggcgat ggccacagcg ccgatgagcg
     6961 gaccccagga ccaggccttg tcggcctccg gggcgtcgtt gtcatccctg ccaatgggct
     7021 tcggggacac gccctggagg atcttccggc cctcggcgga cagttcgctc gcgtagggct
     7081 cgcccagggc catcaggtcg agcgcgtgca cccgctcccg cagttcgttc aaggacgggg
     7141 gcggggcggg gaactcggag ggcttcgtca tggaggcggc ccagcatacc gtacatgttg
     7201 accctacctg tgccgagcgg gcggtcctac acgtgggtgt ctccgggcac ccgcgcgcgc
     7261 tcgcccgcgc tcgcccggcc cgagttcatc tcccacaaga gcgcgtactt ggcgaagacg
     7321 tggaacgcga gcgcggtggc caccgtcagt ccgcccatgc cgaagcggca caggcccttg
     7381 agcaggtaga acttgaagaa ggcgcccacc gtgtggctga cggcgctcgc cagcgaagcg
     7441 cggcgcccac gcgcatggaa gtgtttggcg ccgctctggg cgtagctgat ctgcttgcgc
     7501 agcaggtggg agaccgagtc gtaggagcgg tgggacagcc cgtgctcgag ccggcccgcc
     7561 ttgccctcgt ggagcgcggg cacgtggatc cactccgagt cctcccagcg caccttggcc
     7621 aggcgcagca gccgcttctg cgaggtccag aagtagaccg gccgcggcca gtggtccggc
     7681 agggtgttct tctggggcac gtggtaggcg tcatgccgag gcgagccccg gccgagcagc
     7741 gcgcggatct cctcgcccag tccgggcagg gccttctcgt cggcgtccac gatgagcacc
     7801 cactcgccgc gcgcctgggc gcacatcgcc cggcgatgcg aggcgaaggt gtcgagcttg
     7861 cgctggaagg cgcgtacctt ggccccgcgg gactggaggt actcccaggt gccatcggtg
     7921 gagtgatcat cgacgacgac gatctcatcg cagaagtcga gcgagtcgag gcactccggg
     7981 agggtgcgca ggctgtcctt ggtcatcacc gctgcgctga gcaggacgcg ggggttgtcg
     8041 gggccgatca tgacgccgcc ttctagtgcg ctcccggcca cgtcaggaag gaatctcgtc
     8101 ctcacggagt attgccatgg acctggtccg catcatcttc gccatcatcc ggctacaccc
     8161 ccggtatcgt ccacgccgtc tacatcatcg cgaagcgtcg aggatgtgcc ggtagaagcg
     8221 ccattcggca tccagggcgt gggccaggtt cgccgcctga cggaagccat ggcgctcccg
     8281 cgggtagaaa tgcccctcgg cctgcacgcc ccggctttgc agtgcttgca acatgtcgcg
     8341 gctctgctgc ggtaccacca cggcatccag ctcgccctgg aagaagatca ccggcacctc
     8401 gatgcgatcg gcatgcaata gcggtgtccg tgcgcggtag cgctcggcgt cgcgctcggg
     8461 gtcgccgatc agccagtcga ggtaatcgcc ttcgaacttg tgcgtcaccc ggcccagggc
     8521 caggggatcg ctgacgccat acagactggc gccaccgcga aatacctcgt ggaacgtcag
     8581 cgcgcagagc gtggtgtagc cgccagcgct gccgccgcgg atgaatgcct tgccaccgtc
     8641 gaccaggccc tgctcggcca ggtagccgac cacggcgcag gcatcttcga cgtccaccac
     8701 gccccattgc tcatggagct tttcacggta ggcgcggcca tggttgctgc tgccgcggta
     8761 gttcaggtcg gcgacggcga agccgcgctg ggtccagtac tggatgcgcg tatcgagtac
     8821 cggatagcag gccgaggtcg gcccgccatg gatgaacacc accagcggcg gacggctgtc
     8881 ctcgctgcag gcgggataga agaagccatg ggcggtttcg ccgccgcagg ggtagtggat
     8941 cggccgcgga cggctgatgc actcggcggg caggggcgat tcgccgcctg cgatgacctg
     9001 cgcgttgcag gtctggcggt cgatcgccag caccgccggg gcgctcatcg gcgaggcgac
     9061 gatggcgtag aaatagcggg tgtccaggtc caggccgcgg aaacgggtgt agccgcagct
     9121 gaaatcccgc gggcgatctt ctttttcaca caggcccagg cggccgaagc cgtcctcgaa
     9181 ccaggtggcc aggtagcgct cgccgtccag cggtgcccag gtgctggcgc tgccctgcca
     9241 gggcgccggg gcgtgatcgg ccggcatcgc tggcagcgcg gcccagcctt cagcggtttc
     9301 catccagggt tgccaatagc cgttgcggtc ggacagacag ccgagccggc catcggcgct
     9361 gaaacgcggt tgctgcaggg attcggcctg ctcgccgtcg ccggccacgc accgtgggtc
     9421 gccgtagccg ccatcggcct ggcgtcgaag cgtgcacagc cgcgtgcgcg tccagggctg
     9481 ctgggggcac tgccattcga tccaggccag gcgctcgccg tctgcactct gcacgggcgc
     9541 ggcatagaag tcggcgcctt cggccaatac gaggcgttcg ccaccttcca ggccgatggc
     9601 caccaggcgg tgttccaccg cgccttcggc atgggtctcc tcgacggcca gcaccacgcc
     9661 gcgcccctgg cgcaggtcgc catggcgccg ctcgccccgg gtcagcgcaa ccggatcgcc
     9721 gccgtcgagc ggttggcgat agagctgctg gtccgcctcg ttgacgaaca ccagccagtc
     9781 cggccccaga cagaaggagc caccgccgta ctcgtagacc cggctgcgca cgctgaagcc
     9841 ctccggcgtc aggcagcgcg gctcgtcacc gtcacgccag cgccagatcc ggcagcgggc
     9901 gtcctgggga cggaattcgt tgtagtacag cccggcgggg ccgacccgca gttcggcgaa
     9961 gtcggtggcg gcggcaacgg cctgggcggc gctgaaggat tcagcccttc ttggtgatga
    10021 ggcgcgagtt tcgttcattg cgaaatgtca gttctcctat ggccgcagtg gctgttctgg
    10081 cttcttcgcg ggccttgaga atgaggtcgt ggcgtggaga cttgccacac accggatcgg
    10141 tgttgctggc atcgcccgtc agcatgaagg cctggcaacg gcagccgccg aagtcctttt
    10201 ccttttcgtt gcaggaacgg cacggctcgg gcatccactc gtagccacgg aagcggttga
    10261 agccgaagga gtcgtaccag atgtggtgca ggctgtgatc gcgcacgttg gggaacttca
    10321 ccggtagctg gcgcgcgcta tggcatggca gcgcggtgcc atccggggtg acggtcagga
    10381 acaggctgcc ccagccattc atgcaggcct tgggccgctc ttcgtaatag tcgggggtga
    10441 cgaagatcag cttgaccggt ttgccctcgg cggcgagcct ggcgcgatag tcgttggtga
    10501 tgcgttcggc gcgctcgagc tgttcgcggg tcggcagcag gccgacgcgg ttgagctggg
    10561 cccagccgta gaactgacag gtggccagct cgacgaaatc cgcctccagc gccacgcaca
    10621 actcgatgat gcgatcgatt ttatcgatgt tgtgccggtg ggtgacgaag ttcagcacca
    10681 tggggtagcc atgggccttg accatgcgcg ccatctcgag cttctggtcg aaggctttct
    10741 tcgacccggc gagcatgttg ttgacctgcg cgtcgctggc ctggaaggaa atctggatgt
    10801 ggtccagccc cgcgtccttg aaggcgcgga tcttctgctc ggtcaggccc atgccggagg
    10861 tgatcaggtt ggtgtagtaa cccaggcgcc gggcctcgcc gatcagttcg gccagatcct
    10921 ggcgtaccag gggttcgcca ccggagaagc ccagctgcgc cgcgcccatc tcacggccct
    10981 ggcgcagcac ggaaaaccac tcttcggtgg tcaattcctt gccctgggcg gcgaagtcca
    11041 gggggttgga gcagtagggg cactgcagcg ggcagcggta ggtgagctcg gcgagcagcc
    11101 atagcggcag gccgacggcg ggcttcggcg gcacttcagc caagttcgat ccagtgttgt
    11161 gcacgggcga cctccatgaa ttgctcgacg tcttcaccga gctcggggac gccggggtac
    11221 cgctggtcca gcgcgttgat gatcgtctgc acggagcgga cgccgtcgat cagaccgccg
    11281 atggcggcgg cgctctcgtt gagcttgatc attccttcgg gatagagcag gacgtgagcc
    11341 ttctgggccg gttcgtactg gaaccgatag ccctgacgcc agcggggtgt caggttgcga
    11401 tcgaagctca tagggcgatc cccttgtgcc aggcgcgctg gttggtgacg gtgtggtagg
    11461 gcgggcggtt cagctcgtag gccatgctca tggcgtcgag catggtccag aggatgtcca
    11521 gcttgaactg caggatctcc agcatgcgct gctggccctc gtaggtggtg tagtgagcga
    11581 gggtgatcgc caggccgtgc tcgacgtcgc gccgggcctg gcccagacgg gtgcggaagt
    11641 actcgtagcc gctcggatcg atccatgggt agtgccgcgg ccagctgtcc aggcgcgact
    11701 ggtggatctg cggggcgaac agctcggtca gcgagctgct ggccgcttcc tgccaactgg
    11761 cgcggcgggc gaagttgacg taggcgtcga ccgcgaagcg tacgccgggc agcaccagtt
    11821 cctgggagcg catctggtcg ggatccaggc ccacggcctg gccgaggcgg agccaggcct
    11881 cgatgccgcc gtcctcgcca ggggcgccgt cgtggtcgag caggcgttgg atccactcgc
    11941 ggcggatctc ccggtccggg cagttggcca ggatcgcggc atccttcatc gggatgttga
    12001 cctgatagta gaagcggttg gcgacccagc cctggatctg ctcgcgggtc gcgcggcctt
    12061 cgtacatcgc cacgtgatag gggtggtgga tgtggtagta ggcgcccttg gcgcgcaggg
    12121 cctgttcgaa ttcggcgcgg gtcagcggtg tcttgtcgct catggtcact cctacagctc
    12181 gatgctcatg ccgtcgaagg cgacttccac gccccggcgc tcgagctcgg cacgctcggg
    12241 cgagtcttcg tcgaggatgg ggttggtgtt gttgatgtgg atcagcacct tgcgtggctt
    12301 ctcgaagccg tcgagcagtt ccagcatgcc gccgggaccg ttctggcaca ggtggcccat
    12361 ctcgcggccg gtacgggtac cgacgccgcg gcgctgcatc tcgtcgtccg accacagcgt
    12421 gccgtcgacc agcaggcagt cggcgtcggc catgtgctgc ttgagcgcgg cgtcgacctg
    12481 gtacaggcca ggcgcataga acagcttgcc gccagtgcgt gggtcctcga ccaccaggcc
    12541 caggttgtcg ccggggtgcg ggtcgaaacg gtgcggcgaa tagggcggcg cggcgctgcg
    12601 cagcgggaag ggggtgaact tcaggttcgg gcaggcttcg atggtgaagc tgccttcgag
    12661 cccgatgcgg ttccactgaa ggccaccgtt ccagtggctg agcatcttga acagcgggaa
    12721 gcccgtggtc aggtcctggt ggaccatgtc ggtgcaccag acctgatgcg ggcagccttc
    12781 gcgcaggctc aagaggccgg tggtgtggtc gatctggctg tcgagcagga tgatcgcatt
    12841 gatcccggtg tcgcgcaggg ccctggccgg ttgcatcggt gcgaaggact gcaattgagc
    12901 gcgaatgtcg ggcgaggcgt tgcacaggat ccaatgcacg ccgtcatcgg acagggcaat
    12961 ggaggactgg gtgcgggcct tggcgcgcaa ggtaccgtcg cggtaaccct tgcagttggc
    13021 gcagttgcag ttccactgtg ggaaaccacc gccggcggct gaacctagaa tctgaatgta
    13081 cataaccact cactcgtgcg gcggctgaaa caagaacgcc ccggcgaacc gaggcgttgt
    13141 actgcgggca gctcagcggt tggaggcgta catggtgact tcgaagccga tgcgcaggtc
    13201 ggtgtaagcg ggcttggtcc acataggaaa tgctccttct gagggtggtt gtaaattcgg
    13261 ccttcacatc caggccacct ccaggtggag atgtcccgat gcttgggccg tatgttactg
    13321 aatctctccc ctcgtggact taattttatt gatggtcctc atgcattcct ggcaggagtc
    13381 agactgcctc ataccaagac gcacccgggc aaggcccggt cgccagcgcg gtccagctca
    13441 cctggctggc caacagtcga tgagccgcct cgaccagcgt cgacccatcc agttgaccga
    13501 ccgattctct caatttcgcc gattctctca atctcaatgt attggaataa tccgacgaag
    13561 ggtcggtcaa tcttgcttgc cactgcatct cgagtcgctg cgccagcccg aggttgccgc
    13621 cgtcgaggct gtcggccagc gccgcgcatt gctcgcgcag tcttgtcccc ggccattgcg
    13681 cgagacgctc gggcagggca tcgaggaatt cggcgatgtg cccccacaag gccgcacagt
    13741 cgctgccggg tgactgcaca ccaaacaaca gtccggggcg gccggccagc tggcggaatg
    13801 cgctgaacac cgcatagccc aactggagtt cggttcgcag gcgctggtag aagggcacct
    13861 ggatcaactg ggcgagtgcg cgccaggccg cctcgtcctc gatcgacacg ctcggtgccg
    13921 gacaccacac cagcagtgca tgttcgtccg aaccgcaggt cacctggctc cagttggctc
    13981 ggccgggcag tgtggacggc tggcggagat cgttcgaggc gctgcccggc aggcgcgcgg
    14041 ccacggcgtc cagggcgagc cggtcggctt cgtcgaagcc cagcaccaga ccatcccagc
    14101 gcgcctgctg ccacagccgt tgcagcgctt cggggtgcag ctcgctgctg tcgttgcgcg
    14161 ccgggcggtg gtggcccagc gcatgctcgg gccactgggc gagcagctcg cggatcggta
    14221 cctgctggcg cggagggggg ctggcctggt gccagctctc aggtgtcggg cgttgcagca
    14281 attcctctgc ctgttcgagg atcgccggga tcggctcgcg tacgccgtac aggcgcaatt
    14341 gccagtccag acccaggcgt gagaattcca gttgcacacc agcctggcgg gcttcttcgc
    14401 cgagccggcg caggctggcg tcgagcatgt gccacagcgc ggcgtgatgc cggttggcca
    14461 ggcgccagcg caggtgcacg ccgccctcca ggccgcggtt cggttcgagc tcgccctgct
    14521 ccagggccgc gattcgagga ccggcctggg tcggccggtg ctggccacgc aggaaacggt
    14581 tgcgcggcgg caggcgccag ggaccgaacg gcggcagcag gggcggttcg tccagcgcct
    14641 gggcgccggg ggcgagcagt gcctggggcg tgaaacgttc gagcaatgct cgcaaggccg
    14701 ggacggcttc gtccggcagt tccgaagatt ctccatgggc caggcgccgg gccagctcca
    14761 gcgcaccctc ggtctgcgac tggcggctgc gcagcaggcg atactcctcg cgcaggggct
    14821 cccaaccggc atgggactgg aagtacttca gccagtcgaa gcacagtgtc tgggcctccg
    14881 cccgggattg ctgtccggct tcggtcagct gcacttcgaa gttgaccagg gcctggtcgg
    14941 cgtactggta cagcggactc agcgacaggc tctgggccca gcccaggcgt cgcagttcgg
    15001 ccagcaatcc gccgggatga gcggatccgg cccacggttc caggaaacgc agcgcctcgt
    15061 ccgtgccggg cggcaggccg tcgcatgcga acagcaggtt gagccgtcgc gggtcgctgg
    15121 tcggcggagg ctcgcccggg tcgcccagca gcgtctccac gggtgcattg gcgttgcgcg
    15181 ggcccgcggc cagtgcggca tcggcgtccg tggccagccc cgcgagaatc cgcggcggct
    15241 gcggcccgac caattgcaag gtcatctgcc cggtgcggta gtagcgccga tggaagtcgt
    15301 gcagcgcctg ctggaactcg gggctggcca ccggcaggct gtcgcggttg ccggcatgga
    15361 aggcgcgcag cggatggcgg gccgagactc cgccggccag gcagaacagg tgctgggcct
    15421 gggtatcgcg cgaccaggcg atgaactcgg catgcagcac ttcgcgctcg cgttgctggt
    15481 cttcgatggc caggcgcggc cgggccagca tgtcgcacag ccgctccagg ccctcgccga
    15541 acaccgcctg gggcaactcg aagaaatagt cggtggtgcg ttcgctggtg cgcgcgttga
    15601 cctgtccacc atggtgctgg acgaaggcca tcaacccttg ttcgcgcggg aagcgctccg
    15661 tgccgaggaa caccaggtgc tcgaggaagt gcgccagccc cggccactgc gcgtcgacgt
    15721 cgtggctgcc ggcctcgacc cgcagccatg cggcggcacg acgcaggcgg ggctcatgac
    15781 gcaggcgcac gcgcaagcca tgggcgagga caaggctttc gcggccctgg tcgctggatt
    15841 cggtcatggt ggttcccggg agaaatggac cgttaccggg acatgctagc ggatccggct
    15901 cccctgtgtc gggcgctcat cctgggcgcg cggcgcactc ggagcgccgc gccgccactc
    15961 cctcgcggcg aggagcgggg cgcggcgtgg ggttcagcgc cagtagaggt tgaagttcac
    16021 caccacgggc ccgatcgact cgaccaggag gatgccgggc cggtggcgat agccgatgcc
    16081 gaagcgcacg tggcccgtct tcccgaagag gtgatcgcgc gcgagcatca cgctccagga
    16141 ggagatgcca tccagcgcga gcgagccctc cagtggccgg ttgtcgatgc cgctctggga
    16201 gcgcgcgtgc tggatgttga gcaggggggc cttcgcggtg agcaggaagg cgccgcgcga
    16261 gtcgtgacgc gccagcgtgg tctccacgtg cagcgcgttg ctatcggtcg acgtcccggc
    16321 gaagtcgaag gcgaagcgat ggtagcccgc gcccaggtgg aggttcaggt tgtccgagag
    16381 gggcaccgtg ccacgcacgg ccacgggaat ggagagcacg ttggcgtcga cgagccggcc
    16441 gatggccagc cagtacgccc cgccctccac ggacacgcgc agctccgggc gatccaacac
    16501 ctgcaccttg gcggacaggt tgagcagggt gatgagatag ggcgcgatct ggctggagag
    16561 ctgaacgcgc ggcaggacgc cgaacgcgag ctggccgaag aagagatcga tctgggactc
    16621 cccgggctcg agcacgtccg cgctcacgtc cagcagggcg ttgcgtgggg tggcggcgag
    16681 cgcgggcgag cacaggagca gcagggcgag tgcgagggcc ttcacggttc ttctccgaag
    16741 gtgaagagcg cgccgatgcc cacggagaca tccaaccgct gggcggccca caccagatcc
    16801 atgccggtgc gcagggtgag gggctcgagg tggatgtcca ccgcggcgcc gccggagatg
    16861 ccgagccgcg cggcggtggt ggacacgtgc gtgccaccgc cgccgagcga ggagtggaac
    16921 acggtgaggg ccgggccggc ggcgatcacg aagtccgtgg tgcgcacggg caggtgcagc
    16981 tccggacgca cgctgaagcg gtggtagcgc gtgacgacgt gggccagggt gccctcggag
    17041 gaccaggcga agcggtagtc gccggacagc gccaggtagc gccccagctc gaacacgacg
    17101 cgtgggcctc cgctgagcag ccccgtgcga tgacccggcg cctcctgacg cagcagcagc
    17161 gccacgtcca cgcccgcgcg aaggggaacg gctccggcct gtccggccag cagcaccccg
    17221 ccgagcaaga accagcggct catggtgtca cctcgcaggc ggtgagggtg gaggccaggg
    17281 gctccatccg tttcaggagg acggcgcacg cggcctcgcg ctccccggcg ctcaggtggg
    17341 tcaccagcgt gttggggaac gaggcgaggg tgaaggtgtc cttctcgaac ttcagctcac
    17401 gcaacgtggc gagcgtggcc gtgagcagcc gcgagcgacc ctccggggag atgcggccct
    17461 ggtcatcctt gggccacagc tcatggacgg cccgggccag gagcgagccg tgggcatggg
    17521 gctcgaagcc ttcccccagg agggcttcct gccgctgcct cgaggtgtag tcccgcggct
    17581 cggccatgtc gcggtcggcg tcgacggtgg cgagcacgta gtccgggtct cccgtgacga
    17641 tcagtccgaa cagatccgcc acgccctcgt gcatggcgga caggtcgcgg cgggtgatgt
    17701 cccaggaggc atcgccctcg ccggggatgc tctccaggtc gccgaacatc tcctggtgga
    17761 tgacggcgtg cccgaactcg tgcgccacca cgccctcgtt gagcatcatg ggcaggccgt
    17821 cgagcaggaa ggaggggacg atcaggaagg acggccccac ggagaagtag gccgcgttgt
    17881 cggtgagctc cgcgcggcca tctccgatga ggatgttgtc caggcggggg tagtagagga
    17941 cgtccaggcg gcgccggggc acgtggccgt gggcgcgcag cagcgtggcc gtgcgatcca
    18001 tgctccggta caggctgagg gcatacaggg agtgcatgtc cgccgggacg agggtgccgt
    18061 ccgcctcgcg ggtgtactcc agcgcgaagg gcgagccgcg ctcgtagctg gagggcgtca
    18121 actcggagcc catgcggaag tcgacgtcgc ggccgcgcag ccccctcagc gactccaggt
    18181 tctccaccgg gtgccggccg agcgcgtacc ggcccgtggt ctcgtcgcgc gcgaagacgt
    18241 acgccatcac cgttccggag gcatcctccg gggcgcagcc ctgcatgccg aggcccagga
    18301 gcaccgggcc gagcaggctc ctccaccttc tccgggcacg gaaggtttca acgcggttcg
    18361 tgttcttcat gatgggggcg cggtggatag catttcccac gtgacaggga aatgactggc
    18421 gcccccggcg ccgagtgggg ctcagaccgc cgtccagccc ccatcgatgt cgagcaccac
    18481 gccggtggca taggcattcg tcgccaggaa gaaggcggca tccgccattt cacgcgccgt
    18541 cgccgtgcgc ttcaggggga tgcgctccat gaggctggac atgaacgcat cgagcttctc
    18601 ggggggcacc tgccagtcga tgtcggtgcc acgtgtcagt ccgggcgaca ggacgtttac
    18661 ccggatgccc ttgggggcca gctcgaccgc gagcgaacgc cccatggcgt tgaccgcgcc
    18721 gcacagggcc gcgcccccgg agtagttcac cagggccgca tggcccgcca cgcccgagca
    18781 cagcacgatg gcgctgcccg ggggcatctt cgggacggcg tgatggcagg cggagagctg
    18841 accgaagaag cgcgcgtcga acagctcact ccacgacttg cgtggcacct gctccaccgg
    18901 cccgaacacc gcgcctccgg cgcatgtcac cagcagatca atccggggca cggagtcgat
    18961 gagccgctcg acctgggcct cgtcggcgac gtccgtcacg acacctcgtg cggcccggcc
    19021 aagcttttcc accgccttgt ccagccgctg ctggttccgc ccggcgagca ccacctgtgc
    19081 tccctcgcgc gtgtagcgct ccgcgatggc gaaaccaata cccgagccac cgcccgtgat
    19141 gatggcggtc tttcctttca atgagcccat aatcctctcc atctggtgta agcgggatta
    19201 ttcaaaccat atcatgatca agagaaggac tccacgttct ggacatgtcc tggagcgaac
    19261 tacagacatg gagtcaggaa tgacggagga gggcggattg cccacgcaga gggtggaatc
    19321 cgtgggccgg gacgatttcc aagcaggagg ggtttcccct ttctccgtgg gcctccgggt
    19381 ccggaggctc cgcgttcagg agaggggaat cttgaggatg gccgtggcgc ccttgccggg
    19441 cccttcgctc tccaggctga tgctcccccc gaggatccgc gcctccagcg cgctggagtg
    19501 caggcccagc ccatgcccac cggtgcgtgt ggtgaagccc tggccgaaga gccggctacg
    19561 aatctccggc atgatgccca tgccattgtc gacaatctgg atgcgcgcgg tgttgccttc
    19621 cgtgtccagc cgcacgcgca ggtggcgctg cggctcgggc atgggattca tggcatgttt
    19681 ggcgttgctg atgaggttga tgaggatctg caacaccttg tgtttgtcca gacagacctt
    19741 ggggacgggg gagagctcct tggtgacggt gatgccgtgg cgctggagcg aggcccgctg
    19801 gaggctcagg gcatcctcga cgagccgtgc gaggtcgcac tcctcggtga cgagggtgct
    19861 gtgggcatag gtctgctgga cctggacgat ggcccggatg tgctcgatgt gcttgtccat
    19921 ggcggccatg ccctcctgga gcgaggcgcg ctcgcgcagg agctcctcgg tgagcgcgga
    19981 caggtagccg gggagctgcg cgccgcggat atcccgggcg aagaagcccg cgagatcgtc
    20041 gtgatgctcg tcgagcatgt gggtgacctg cttgagccgt cccaggcgcg aggcgttcat
    20101 cgtctcacgc accacctgga gattgatgac ggcgctggtg aggacgttgc ccacgttgtg
    20161 cagcacgttg gcggcgatct cggccatgcc cgcggcgcgc gcggcgtcca ccaggcgcac
    20221 ctgggtgcgc ttgagctcgc gcgtgcgctc ctccacgtgc ttctccagct cgtcgttgga
    20281 gcggcgcagg gcggcctcgg cgttctgcac gtcggcgtac agccgcgcgt tctcgatgga
    20341 gatggcggcc tgggaggcca ggtggccgag cagcgcgatg cggcccgggg tgaaggcatt
    20401 ggtggccagg gtgttctcca ggtacagcac cccgcggaac tcctcccggc gcagcagtgg
    20461 caggcagagc accgagcggg cgtggctctg ctcgagccag gcgtcggacg agaagggatg
    20521 gggttgggag gcgtcaccaa tgagcacgtg ctcgcgcgtg cgcttgacgt aggagatgac
    20581 ggtccagggc aggtaggact cggcgccgcc ggtggtgggc tgtccggaga cggtgcccga
    20641 cagcgccgcg atcgcgagct tgccgtcttg cggcaacagc aaggcgccgc gctgtgcccc
    20701 ggcgttctcc atggcgatgt gcaacagcga ggccaccagc cgctcgagga cgatttcctc
    20761 ggagatggcc tgctgggcct tcaccagggt gagcgcgtcg atccgcgtcg agctggtgtc
    20821 cgagacgttg cgcgcgccgg gctcgggagt ggccagcaaa ggccattccg attccatgtg
    20881 ctgcaccttg ccctgcgctc cccagcggag gtaggcctcg cgggccttgc gggcgtaggc
    20941 ctcggcgatg gtggggacgt gctgctcgcg ccagaagcgg gcggccagct cgtacgcgag
    21001 ggcggcccgc tggaggaagc cgtgctcgcg cgcggactgc acggcgtgct cgtaggcctg
    21061 gatcgcctcg tcccgctggc ccgtgagccg ggcgagctcc gcggcgacga gccgctcggg
    21121 ggcgaggaag gtcgagggac agtgccgggc ccactccgcc agttgttgct ggtgccgccc
    21181 tagctccgcg agggcctgct gccgcttctc gggcgtcatc ctcgcgcagc aggcggccag
    21241 ggccagggcg cggaagaggt gcaggtccat gagctggatg tgtccgagcg aggaccagct
    21301 cagctcctgg ctcttgttgg cgtactcgag tgcctccggg tacgcgccgc tcatgtagcg
    21361 cgactgcgcc ttgatgagcc agtaccagca gcgcatggtg ctcatgcgtt gcggcgtcaa
    21421 cccggcctcg aaggtctcct cgtcgaagtc ctcgccattc atcgtgccga acgaggccgt
    21481 gagaccgcgc agctgctgca catggcgttg ggtgaaatag atgatgtcgc ccgagtccag
    21541 gaagtcggct ccccgggtga agtgcaggtt cgccaccgac tcccggtaga cctcctccag
    21601 ctcgtgcccc aggaggaagc ggtccgtgac gatgtggttg cagcagtagc cggcgatctg
    21661 gctgtcactg ctctggagcg cctgttggaa ggcctcgcgg acgagcccca gcgcgatgga
    21721 caggggctgg gtccagtagc tgatgatctc caggccgtag agcgccttgg cccgcagggc
    21781 ggtgaacccc cggctctcgg cgagcgcgca cgcgagctgg ccgaaggcat ggccctccgg
    21841 gaagcgcttg aaggcggggc cgagcaccac tccgtaccag gagtagccgt gcacggaggc
    21901 ggccgtgttg ccatgacgga ggctgagcgc gaccatccgg ctgaggtgga ggatgagcag
    21961 attcgtgtcc gtgacgaacg cgggcgcata catggcgccc agcaggctca tcaccgcctc
    22021 catgtccgga tccgtcatgg ggggcagcgt gacgaggctc tcgatgggac gctctcccaa
    22081 cagggcccac acctccgcgt tggcggcctc cacctcctcc caggtggggt gcggggacat
    22141 gggcatgccc accagggcca gtc
//
