LOCUS       NZ_CP022098            23270 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Cystobacter fuscus strain DSM 52655 chromosome, complete genome.
ACCESSION   NZ_CP022098
VERSION     NZ_CP022098.1
KEYWORDS    RefSeq.
SOURCE      Cystobacter fuscus
  ORGANISM  Cystobacter fuscus
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Cystobacter.
REFERENCE   1  (bases 1 to 12349744)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12349744)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 10:04:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,093
            CDSs (total)                      :: 10,016
            Genes (coding)                    :: 9,906
            CDSs (with protein)               :: 9,906
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 26 of 110
            Pseudo Genes (incomplete)         :: 101 of 110
            Pseudo Genes (internal stop)      :: 1 of 110
            Pseudo Genes (multiple problems)  :: 17 of 110
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:24:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1479558
            Orig. end                         :: 1502828
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23270
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="7"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23270
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23270
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13270](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13270)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    77..87
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    248..266
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.22"
                     /tool="antismash"
     misc_feature    421..436
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.19"
                     /tool="antismash"
     misc_feature    428..441
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.69"
                     /tool="antismash"
     misc_feature    655..669
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 23.72"
                     /tool="antismash"
     misc_feature    739..753
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            complement(1203..2054)
                     /locus_tag="CYFUS_RS06200"
                     /old_locus_tag="CYFUS_001235"
     CDS             complement(1203..2054)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631742.1"
                     /locus_tag="CYFUS_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001235"
                     /product="hypothetical protein"
                     /protein_id="WP_095984389.1"
                     /transl_table=11
                     /translation="MHLSTRLRALGALLSLGVCALFGVPTAHAANSTACSGGGFALTLP
                     NGTPLVIKAKGGGDRIEVPSQSLPSHGILKVRGKYVDFDVDVSTFAVYNYTLKATSNPL
                     DITGGVTTMLFTRKEPILGTTTLDGSSMRVENKDGGVRLIREGQSLKMKIQANDCAQGG
                     IFQLEPEWATETGTIDFVHTLGPNVFYFTNPYTGKINFGNLDLIRGKDSPQVAAKLVQD
                     EHETVWRVTSGGRMGGVLGEDAVENSPAATPCTKNCQAQNQVHGRYDVPDPVYESDGDG
                     ED"
     CDS             2082..2303
                     /gene="allorf_01481640_01481861"
                     /locus_tag="allorf_01481640_01481861"
                     /protein_id="allorf_01481640_01481861"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVLKRIPRWLDPAVVRLTPVSGAYKYNRRQKQWMSWWGAGSGGVH
                     FRQGMDLECADEHRCGCFVGMLWPAWCV"
     CDS_motif       2082..2150
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVLKRIPRWLDPAVVRLTPVSGA"
                     /locus_tag="allorf_01481640_01481861_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2151..2303
                     /prepeptide="core"
                     /locus_tag="allorf_01481640_01481861_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.60"
                     /molecular_weight="5889.7"
                     /monoisotopic_mass="5885.7"
                     /core_sequence="YKYNRRQKQWMSWWGAGSGGVHFRQGMDLECADEHRCGCFVGM
                     LWPAWCV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVLKRIPRWLDPAVVRLTPVSGA"
                     /leader_location="[2081:2150](+)"
     misc_feature    2130..2143
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.38"
                     /tool="antismash"
     misc_feature    complement(2209..2220)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            2457..2906
                     /locus_tag="CYFUS_RS06205"
                     /old_locus_tag="CYFUS_001236"
     CDS             2457..2906
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620501.1"
                     /locus_tag="CYFUS_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001236"
                     /product="MaoC family dehydratase"
                     /protein_id="WP_095984390.1"
                     /transl_table=11
                     /translation="MRYFEDFQVGQIHELGTYEVTREEILTFARQYDPQPFHLDEEAGQ
                     RSIYGSIIASGWQTAAICHRLLVRAVLEDSASMGSPGLDELRWLRPVRPGDTLSARIEV
                     LEVTPSRSKPDRGSVKTRMEVRNQQGEVVMTELASVLFRRQPATT"
     misc_feature    complement(2957..2972)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            2967..3992
                     /locus_tag="CYFUS_RS06210"
                     /old_locus_tag="CYFUS_001237"
     CDS             2967..3992
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012472.4"
                     /locus_tag="CYFUS_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001237"
                     /product="aldo/keto reductase"
                     /protein_id="WP_232537403.1"
                     /transl_table=11
                     /translation="MIDYTRLGKTGAEVSRVCLGAMTMGTLMDRDESFRTLDFFAEQNG
                     NFIDTANCYSWWVGKGENVGDESEVMLGEWMQARRNRERVFLATKCGARIPDSRAIRDA
                     DGTPRWAEVPSNYEGASRRVILGAVRDSLRRLRTDYIDLYYVHVDDRKTPLEETLGTMN
                     ELVASGVVRHLGYSNVRTWRLERIRAICERNGWAQPVAVQQEYSFLRPAAGANLGIAVH
                     ADDEFFDYLAEDPSMTLLAYSPLLKGIYASREKRLAYYNWPLYDTPDSAARLERLEVVG
                     KRLGIDGNTLVLAWMLHRKPAIIPVVGGSRFNHFRENLAALDVRLDRETIDYLEGGSAG
                     A"
     gene            4048..4275
                     /locus_tag="CYFUS_RS06215"
                     /old_locus_tag="CYFUS_001238"
     CDS             4048..4275
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001238"
                     /product="hypothetical protein"
                     /protein_id="WP_198316473.1"
                     /transl_table=11
                     /translation="MTYAEYPDDEREAVVAAHPRTEHFKEDIIQAFYDGIKHKPRTTFG
                     NVKADVIADKEPLFIRGNFCRVIRESAWRG"
     CDS_motif       4048..4098
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTYAEYPDDEREAVVAA"
                     /locus_tag="CYFUS_RS06215_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4099..4275
                     /prepeptide="core"
                     /locus_tag="CYFUS_RS06215_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.60"
                     /molecular_weight="6740.6"
                     /monoisotopic_mass="6736.5"
                     /core_sequence="HPRTEHFKEDIIQAFYDGIKHKPRTTFGNVKADVIADKEPLFI
                     RGNFCRVIRESAWRG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTYAEYPDDEREAVVAA"
                     /leader_location="[4047:4098](+)"
                     /alternative_weights="6758.6"
                     /alternative_weights="6776.7"
                     /alternative_weights="6794.7"
     gene            complement(4331..4654)
                     /locus_tag="CYFUS_RS06220"
                     /old_locus_tag="CYFUS_001239"
     CDS             complement(4331..4654)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013375584.1"
                     /locus_tag="CYFUS_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001239"
                     /product="hypothetical protein"
                     /protein_id="WP_095984392.1"
                     /transl_table=11
                     /translation="MFKTLAVGLLSSSALVADVSVDQPTSEQFEIPSSGLTFWAGKTFD
                     SPYINYQTVSSECTNLPFDAWAGLNMISGDRILAYTGPDCTGIAFGFSFHSFNYAAKSF
                     KPR"
     misc_feature    4739..4753
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     misc_feature    complement(4741..4752)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     misc_feature    complement(5043..5059)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.96"
                     /tool="antismash"
     gene            5160..7304
                     /locus_tag="CYFUS_RS52375"
                     /old_locus_tag="CYFUS_001240"
     CDS             5160..7304
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024709.4"
                     /locus_tag="CYFUS_RS52375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001240"
                     /product="DUF4082 domain-containing protein"
                     /protein_id="WP_095984393.1"
                     /transl_table=11
                     /translation="MRRFHHSASRLCLFLSLGIIMGCTQGTPAVHESRSTASGLASEIS
                     IFGTSVSPSSLEDSDTASVELGVKFRSSVPGAVTGIRFYKGSAANAGTHVGSLWNRAGQ
                     RLASATFTNETATGWQTVRFASPVSITANTTYVASYLAPRGRYSATVGYFAGQDATNGP
                     LTALASGVDGQNGVYVYGSGGFPTQSYQNTHYFVDVLFLPTPDTSAPSAPGSLVATASA
                     PGSIQLTWDAATDDVGVTAYLIFRDGDEVASVSGTTRGYRDLGLAASTLYHYTVKARDF
                     AGNVGAASNTASATTSDQQPPDGLNLPRVPWEGGPAFYARFPAMAGTPWLSEDFFPIGY
                     WGAYTDEERRIATDKAHGINTFLETYAGNGSSAGWMRQHGIWNLAGSGLGGEAVGTTFY
                     DETDMWAGPGWDPWTGNVATYDVCIPDDPRRCGFTIYNALYQELNNPNAFIYANVGKGA
                     LMWWSDEQREIGINGADGPDPRANWRFGMVTGDIYFYTDGNIGGEAPNWFGIPANEVRR
                     AANYGEILMTNLRSASGAGNNGEPRIPLGVIVELGGQAQGSVITADQVEGAVWSTLIHE
                     ARMLGYFSHVFSDSTANPFSTDVLNDSRAEYQATRERVKKINAEVTALARILNTQSYVW
                     QFNPSLSTMLKYRDGAAYVFAMQKRQFTSGTYTFTLPAELPASGTLEVLGENRSISYSG
                     GRFTDSFSAEYSHHSYRIPD"
     gene            complement(7390..8781)
                     /locus_tag="CYFUS_RS06230"
                     /old_locus_tag="CYFUS_001241"
     CDS             complement(7390..8781)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020826.4"
                     /locus_tag="CYFUS_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001241"
                     /product="FAD-binding protein"
                     /protein_id="WP_095984394.1"
                     /transl_table=11
                     /translation="MMSEKTRTSLVRDLQRLLEGEVTEEPEVLERYSQDFGRTVRRMPA
                     ALARPRDAEEVARIVRYAHARDLPVASRAMGHSMRGQSLCEGGIVIDMRALRGLEEISP
                     DARTFVSQPGVLWREVVAASTAHGLTPPVLTSYPHASVGGTLSACGWGTASVRYGAQLD
                     HCVELEVVIGTGEHLRCNREQEPELFDHVRGGMGQFGLMTKIRYQLRRYHSTVRTYVLE
                     YDDLGAWLEDSRTLVVRDEADHLDCALQQKPDGQGVRWTGVITASLEREAPEDRDGQRL
                     LAGLRFARHISTQDVPTAAFVSQASNPEKPPLPGEAYPWMVTFMPWSRVQPFLELCIRR
                     IPPAALGSANGPMRLWPAFRRVTQVPMLQMPREEIMAMLSICPATTQEGLPIMMSVMSK
                     LSDVGMEVGARRHLGTWVHFDRARWRMHFGEAWPTINRLKRTYDPKGILNPGFIDFEPE
                     SALAS"
     gene            complement(8778..10004)
                     /locus_tag="CYFUS_RS06235"
                     /old_locus_tag="CYFUS_001242"
     CDS             complement(8778..10004)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF018434.4"
                     /locus_tag="CYFUS_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001242"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_095984395.1"
                     /sec_met_domain="MGT (E-value: 2.6e-36, bitscore: 124.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYLFCSLDNFGFLFSSLGIAEALRRRGHEIAFVTDLKLAGVVER
                     AGFQRIPRGEPDGSSFLVEISGHPMDTMRQVRHVERALERFPADVLVTQQLALGPYVVA
                     ERKALPVATVGMASYLWPHGPPPEEAEQREKLVRRYRGFYLAYALVREMLGMERRAHDI
                     HESPLVGDLFLLRSVPELEGNVETLPPQVHFVGDCLWEPPGPPDAELDTWLAAARESGE
                     PLLYVQPGRAFNKRAFWRSLVEALTGQPVRVVAAVGRMDREVEQVPENFFVRPHVSQGA
                     ILPHARAVVSNATTTSVLGALTHGLPLLLIPGGGGAEQPDITQRCVRVQAGLHLEDNEA
                     EPARLLEMVRELLGREELRTAAARLQSTFQRAGGHERAAHLLEELGRRRAPVWREPPSA
                     TQTPARGET"
     gene            complement(10001..13270)
                     /locus_tag="CYFUS_RS06240"
                     /old_locus_tag="CYFUS_001243"
     CDS             complement(10001..13270)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CYFUS_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001243"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_095984396.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-106, bitscore:
                     356.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.2e-63, bitscore:
                     214.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMRPEASEVVEGVNPEGPGWHKGTTLSERVRHLGPPPPPGTTAE
                     AGKDKARATRRLARWRSRAPLDRDELFAQRLALDGATEEQLLQLLGESTETLAARLGPP
                     PEWQTRLARLYTHPVAAEPPARAIPGSPLATPTFLVLAEPLIDESRARLVRALGAVVTR
                     HPDAPFEPESAATLCMPFLCKRLLSQLTRTLALELNVAREEERLQGDNAEERFRGFTES
                     LRQREVALALFAEYPVLARRLVICADNWFISSLEMLERLAADHRELGASLGLPLALDRL
                     SACELGKGDAHRGGRTVAILTFASGARVVYKPRSLAADVHFHQLVGWLNARSEAPHLRP
                     VGAIDRGAYGWMEFVAQRSCATREEVARFYARLGSWLALMYALEATDVHFENIIAVGEH
                     PCLVDLESLFHAHFAVGETRGAEDLAERAKDDSVMRMGLLPQRGWSGEGSEGIDFSALG
                     STAGQLTPRAAQVWEQTGTDEMRMTRRRVEVAASANRPTLKGEDVNFLDFNEPFQEGFS
                     QMYRLLLAHREALLAPDGPLERFAPDETRVILRPTYFYHLLERESCHPDHLRDGLDLER
                     FLDRLWGTIDQIPYTRPLIPHEHEDLWHLDVPFFGSRPGSRDVWSSSGQRLAEFFPRTG
                     LELSRDRIQRLSEEGLTQQLWFIRASFTSLSVMAGGGRMPSYALSVSHEAPRREPLLEK
                     AEAIGDRLAALAFRGQSDASWLGLTPVGERYWTLSSLDVDLYSGLSGIMLFLAYLGHLT
                     GQPRHTALARETLSTVRRRTGGGSFSPRNLGATGDLGVIHSLVHLGALWNQPELWDEAE
                     ALLSRRLRMLIAEDKSLDVFTGVAGCGTLMLELHRCRPSPQALELARQCGERLLTAAHK
                     TEKGLGWVTPLGPLPLTGFSHGAAGIAWFLLALGTETGDPRFQEAARRALAYERAEFSP
                     ERRNWRDLRAVAAEGGFMTTLCHGAPGIGLARLLSLPYLDTPEVREELRVALETTRVQG
                     FGGNHSLCHGDLGNLEVLTLAARTLADSELERECDRLAGAIVASFDRVGLLCGVPTGVE
                     TPGLMTGLAGIGYALLRLAEPSRIPSLLAFEPPRPIGAREP"
     gene            complement(13245..14336)
                     /locus_tag="CYFUS_RS06245"
                     /old_locus_tag="CYFUS_001244"
     CDS             complement(13245..14336)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001244"
                     /product="hypothetical protein"
                     /protein_id="WP_095984397.1"
                     /transl_table=11
                     /translation="MVDSHLDVRLASEAVREDMRRIARMLPPVLGFQFECRLGSPASRV
                     DLLPRLLLTDGSCDALLGLGDTPPTLPEVARDHPTWRALGDFCREWRKPGGALNTGVMD
                     VFLEFDLDHPPPEVPEPCVFMDFARPVRQTREFAERGLDLLLGDRLPASTRRRLAACYE
                     ALPPEARIYSVGVMFPRGTSALRLCLSGASLPRWLSYLERIGWPGQPGEVEAALGRLPE
                     LADQLSLDIDVGETLGEKVGFEFAIQAPIGSSQPRWETLLGHLVERGLGLPDKREAILA
                     WVGHMQQRSQPESWPKELSRIARELNGRGLSLFLRRLSHLKVVHQPGRPLEAKVYLETL
                     HRWLHYSDAQQGYVLDDDAPRGV"
     misc_feature    14473..14491
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.14"
                     /tool="antismash"
     misc_feature    14474..14490
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            complement(14484..14660)
                     /locus_tag="CYFUS_RS06250"
                     /old_locus_tag="CYFUS_001245"
     CDS             complement(14484..14660)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002635010.1"
                     /locus_tag="CYFUS_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001245"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_095984398.1"
                     /transl_table=11
                     /translation="MKKTIQAWKDEDFRLSLTEEERAQLPANPAGIVELSDEALDSLLS
                     GGKQVSSCCWESC"
     CDS_motif       complement(14577..14660)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKTIQAWKDEDFRLSLTEEERAQLPAN"
                     /locus_tag="CYFUS_RS06250_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14484..14576)
                     /prepeptide="core"
                     /locus_tag="CYFUS_RS06250_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="2976.3"
                     /monoisotopic_mass="2974.4"
                     /core_sequence="PAGIVELSDEALDSLLSGGKQVSSCCWESC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKTIQAWKDEDFRLSLTEEERAQLPAN"
                     /leader_location="[14576:14660](-)"
                     /alternative_weights="2994.3"
                     /alternative_weights="3012.3"
                     /alternative_weights="3030.4"
     gene            complement(14718..16988)
                     /locus_tag="CYFUS_RS06255"
                     /old_locus_tag="CYFUS_001246"
     CDS             complement(14718..16988)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="CYFUS_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001246"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_095984399.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.6e-30, bitscore:
                     104.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSGRAPSSIASSLWRRLFPPRPPLVLQATATDCGAACLARILA
                     HAGRPTSVAECQDRLGVTRDGVRPRMFVDAARELGLRAKVFSTDLEHLGQIRLPAIAHW
                     NFNHFVVIEQWSPKGAELFDPVVGRRHVSAQEFSKGFTGVVLTFEPGPEFMTGGPLPSP
                     WSTFLRPLLGNRAVKGLALQVLAASLLLQVLGLAVPLMTQVLVDHVLPLRGFSMMALLG
                     VGMVAVTLSQAVTGYLRNVLLVSLKGRFDEHLLLGMLGHLLRLPFRFFMQRTSGDLLAR
                     LSSAGMIREVLTNQTLTTVLDGSLMVTYLAILSFQAPLFGAVVFGLGVLQLMLVLMTAG
                     RMRELLNRGLTTEAEFQSFTVQAFKGMALVKASAAEELTLRFWSSLFHRQLDASLERGH
                     LTAFINALLNALRTFAPLALLWLGAIQVLDGKMGLGTMLALNAIAAAVLTPLAQLVTTG
                     QQLHLAGAHISRILDVLEAEPEPQPVTTRPTPRLRGHIHLENVGFRYGRGSAPVLSGLS
                     FTIEPGQKVAVVGRSGCGKSTLGSLLLGLLEPTEGRILYDGLPLRELDVRQVRAQFGVV
                     MQEPLLFSGSLRENVSLNAPGIALGQVEEALRLAALEQEVQRMPMRHETWIGEGGAGLS
                     GGQRQRLALARALASRPTLLLLDEATSHLDTATEAQVDANLGIMSCTRIIIAHRLSTVR
                     SADLILVLDQGRLVEQGTHDTLMKRNGLYAALARGQAADATPTPPREARGETDLAQEPG
                     ARA"
     gene            complement(16992..17609)
                     /locus_tag="CYFUS_RS06260"
                     /old_locus_tag="CYFUS_001247"
     CDS             complement(16992..17609)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001247"
                     /product="hypothetical protein"
                     /protein_id="WP_095984400.1"
                     /transl_table=11
                     /translation="MAEGAPENGTSAANQVVYRPEAIAAHRQAREHFRASQYTSSRTLA
                     LLWATSLASVAFGVALVAVPVPAHVSGTAIVVPAAPSPGAGGEGLMLVAFFPPEARTRL
                     AAGQRLLVDVSGKGVRLESHIKEVEQSVVSPEAALERFGLKGDSRQGPNGPTACAFAVF
                     APPGTEGLSATDWLGSTFRVEVEVGQQRLLTSLPILARFLKG"
     CDS             complement(17647..17766)
                     /gene="allorf_01497205_01497324"
                     /locus_tag="allorf_01497205_01497324"
                     /protein_id="allorf_01497205_01497324"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPEAEAPGGATRRNGSSPVKSTECSSQFPIFDLISTEAP"
     CDS_motif       complement(17737..17766)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPEAEAPGGA"
                     /locus_tag="allorf_01497205_01497324_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17647..17736)
                     /prepeptide="core"
                     /locus_tag="allorf_01497205_01497324_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.50"
                     /molecular_weight="2993.3"
                     /monoisotopic_mass="2991.5"
                     /core_sequence="TRRNGSSPVKSTECSSQFPIFDLISTEAP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPEAEAPGGA"
                     /leader_location="[17736:17766](-)"
                     /alternative_weights="3011.3"
                     /alternative_weights="3029.3"
                     /alternative_weights="3047.3"
                     /alternative_weights="3065.4"
                     /alternative_weights="3083.4"
                     /alternative_weights="3101.4"
                     /alternative_weights="3119.4"
                     /alternative_weights="3137.4"
     misc_feature    complement(17666..17679)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(17672..17681)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.31"
                     /tool="antismash"
     misc_feature    complement(17678..17692)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(17927..19861)
                     /locus_tag="CYFUS_RS06265"
                     /old_locus_tag="CYFUS_001248"
     CDS             complement(17927..19861)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013375493.1"
                     /locus_tag="CYFUS_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001248"
                     /product="S9 family peptidase"
                     /protein_id="WP_095984401.1"
                     /sec_met_domain="PF00561 (E-value: 7.5e-06, bitscore: 24.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.1e-50, bitscore:
                     171.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFRSTLVRVLAAATLVPALALAAPNATPAPAVPRPSKQYTVEQF
                     MTTTKLSGASFSPDEKRVLFSSNESGIFNAYTLPLSGGKAKALTHSKTDSTYAVSFFPK
                     DERILFTRDQGGNEANHLFVRTPDGKERDLSPGDKLKAMFVSWSDDDSAFYVLTNERDA
                     RFFDLYRYDAKTYARTLVYQNDTGLSFEAVSPDGRWIAFNKVRTTNDADIHLYDVEKKE
                     LKHITPHQGDAFFQASSFDPNSSALYFLTNQGSEFKRVARYTLTTGVMEEVERADWDVM
                     YTYFSRKGGFRVTAINEDGRTVIRVHDQKTGKLLELPQLPAGDITSVRISDSEKRMAFY
                     HNGDRSPSNLFVYDFGTKKVSRLTDARNKQMDPEDLVEAQVVRFKSFDGMEIPNILFKP
                     HQATADAKAPAIVWVHGGPGGQTRKGYSPVIQYLVNHGYVVLGINNRGSSGYGKSFFAA
                     DDQKHGHEPLLDCVEARKYLASLPYVDAERIGIAGGSYGGYMTLAALAFHPDAFKAGID
                     IFGVSNWLRTLQSIPPWWESQREALYKEIGDPAKQEQMLRDISPLFHAEKISKPLLVLQ
                     GANDPRVIQPESDEIVQAVKKNGIPVEYVIFPDEGHGFTKKKNEVEAYSRMLGFLNAHL
                     RDSGPTPVN"
     gene            20122..20310
                     /locus_tag="CYFUS_RS06270"
                     /old_locus_tag="CYFUS_001249"
     CDS             20122..20310
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001249"
                     /product="hypothetical protein"
                     /protein_id="WP_095984402.1"
                     /transl_table=11
                     /translation="MDRLRAAEVYVAVVEAGSFSAAARALVMNSGALRGLPTPCTQANA
                     RSNKTKPFRKDDRPAGI"
     CDS_motif       20122..20157
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDRLRAAEVYVA"
                     /locus_tag="CYFUS_RS06270_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       20158..20310
                     /prepeptide="core"
                     /locus_tag="CYFUS_RS06270_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.50"
                     /molecular_weight="5073.7"
                     /monoisotopic_mass="5070.7"
                     /core_sequence="VVEAGSFSAAARALVMNSGALRGLPTPCTQANARSNKTKPFRK
                     DDRPAGI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDRLRAAEVYVA"
                     /leader_location="[20121:20157](+)"
                     /alternative_weights="5091.8"
                     /alternative_weights="5109.8"
                     /alternative_weights="5127.8"
                     /alternative_weights="5145.8"
                     /alternative_weights="5163.8"
                     /alternative_weights="5181.9"
     gene            20334..20849
                     /locus_tag="CYFUS_RS06275"
                     /old_locus_tag="CYFUS_001250"
     CDS             20334..20849
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="CYFUS_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CYFUS_001250"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_095991836.1"
                     /transl_table=11
                     /translation="MDAREDQDRAFVDWLAPHLATLRRIARAFAPPEDQYDLMQELMLA
                     VWNARPSFQARSAATTFVYRVAHNTALTWKRGETRRRRRREAIEVEMLWRAEQDRAEPE
                     AGLLERLYAAIRVLPPLDRSLILLSLDGLAYAEIARLHGLSETNVGARLTRIRRRVTSL
                     VEGADDGF"
     gene            20839..21438
                     /locus_tag="CYFUS_RS06280"
                     /old_locus_tag="CYFUS_001251"
     CDS             20839..21438
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001251"
                     /product="hypothetical protein"
                     /protein_id="WP_095984403.1"
                     /transl_table=11
                     /translation="MDFDKLEAAWRSPANTPDDRAQAYLMEELMRTLKARRRRELLFYA
                     IPATAMTIFTAITVQAIAAGRMDVGREWASLVMLAMCWLVLAAVLVVGFLLRSRGRSGG
                     SPVRDTLTTMLVANRRARANVKIFWMMLPVFLAPMLVGVQQLREVGKATDRDAWQMLFV
                     FGVALVASVGWNTARYVWVLKPEQRRLEALLAEYEA"
     gene            <21478..21654
                     /locus_tag="CYFUS_RS06285"
                     /pseudo=""
     CDS             <21478..21654
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026917.4"
                     /locus_tag="CYFUS_RS06285"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="Imm52 family immunity protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GEVSPLPPPVRTEPVEDKGTLIVLAPERLRASNPEHLSLGRGVQE
                     VLDSKGLLRPVLS"
     gene            complement(21713..22309)
                     /locus_tag="CYFUS_RS06290"
                     /old_locus_tag="CYFUS_001252"
     CDS             complement(21713..22309)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001252"
                     /product="hypothetical protein"
                     /protein_id="WP_095984405.1"
                     /transl_table=11
                     /translation="MPISAEELLSVVRKYWRSDHEFDGKLERSPELKRFQALWKQELKK
                     LDQWRVLMRELRAALPQFEIGHATATSTSCFRCTVFTDRQSVEASHEDGPRERRWGVVG
                     CLSILAPIYTVYGLQYDYKGKDVIAAKVFFDPLPPEMQALAEVVGRKIEAMFGAEALPR
                     EIAETRIPLIVDLLEPPATTLFHALFATDPENVAV"
     gene            complement(22314..22871)
                     /locus_tag="CYFUS_RS50365"
                     /old_locus_tag="CYFUS_001253"
     CDS             complement(22314..22871)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CYFUS_RS50365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CYFUS_001253"
                     /product="hypothetical protein"
                     /protein_id="WP_157758274.1"
                     /transl_table=11
                     /translation="MALDGRFLGDGRDDVPGAWLTLLIQGDTVGISRQLAWMSALLRLP
                     GVLLPVVSGCSINQYQPSHFQFTTIVEKTEAGADGWRAACIHATVVNKSTLEPYFCKFG
                     VGMPIATEKFGLMSEPLAQRIAADCANEALREVIASPASPLPGLVCRQFTSTFNVVLNR
                     AVLGSRVTAWCEEETKPIRVDF"
ORIGIN
        1 cacctcaccc ggttcctcgc cctcaccggg ctcctccacc tccggcgcgg cgccgaacca
       61 cttcccgccc accgcatgcc ctgtcaccag cgaggccagc ggatcccacg actccgtggg
      121 caaccacgtg ggcagcatct tgcgcaccat cccgaatccc gcggtgggct gtaccacctg
      181 gctgggagtg ggctgggact gtgagggatt ggggatctcc gcgcgcgtgg gcgcgagcca
      241 gttggtgaac tggatgcgca gacagtcccc gacgttggcg cgcagggtca gtggccgcgg
      301 gcgcttgtcc aagcgcagcc gtgcgttgcc gggcccgatg ggcttggacg cgtcgatggc
      361 ctccacgtcc cgcttcaggg cgtacatcat ccccgagggg ttgtacgcgc cgaaccggtt
      421 gtaggtgtag acctgatcca acgccaccac gttcgcggtg agggtgcgcg cacacgacac
      481 ccgcgtgcca gccgtgggcg ctggccccac caggggcatg tcttgcgagg ccatgggctg
      541 gactccggag gagaccgcct cctcctgccc ggtgtcggtg gtgtcgccct ggcaggccaa
      601 ccccaccgcg aatagcgtgg ccagaagcgc ccggcgtgac accggatgcc aaccgggccg
      661 ccaggcccta tcgagtcttt gtcgtgccga catttgttcc gtcctgaatg agccgtgtac
      721 ccgccattcc tgagagcttt ctcaagctga gagtcttctt gggaatgtgt ctcttcggag
      781 aaaacccttg caggccatag caagtgcttt cctggcgaca gtgagtgacg gtgaaccatt
      841 aatgagatga agtcagcgaa gtaaagcctg tccgtaacca cgcgaactca ctggcagtgg
      901 aaccgggcgc gcgggcttgt ctgagagttc tctgaggaat ggcccgcctg gaatcacgcg
      961 agccttcggc tccagcgtta ccagtgggga ctccaacggg gacgggggct ggcgcgggct
     1021 cgaggcgatt cgtcacgacg aggtgaactc ccgccccagc tccatccagc aaacgcactc
     1081 gccggctgag aatcctttca ggattcccgc cggcgtctgg cttaaaaacc tctcaggaat
     1141 ccccctcggg cggggtgctc ttccgggcga gcacggcccg aggggaattt tgaagaaagc
     1201 cgctagtcct cgccgtcgcc gtcgctctcg tagacgggat ccggcacgtc atacctgcca
     1261 tggacctggt tctgcgcctg gcagttcttg gtgcacgggg tggcggcggg ggagttctcc
     1321 accgcgtcct cacccagcac gccgcccatg cggccaccgg acgtgacacg ccagaccgtc
     1381 tcgtgctcat cctggacgag cttcgcggcg acctgggggc tgtccttgcc ccggatcaga
     1441 tccaggttgc cgaagttgat cttcccggtg tagggattgg tgaaataaaa cacgttcgga
     1501 cccagcgtat ggacgaagtc gatcgttccc gtctcggtgg cccactccgg ctccagctgg
     1561 aagatgccac cctgggcaca gtcattggcc tggatcttca tcttgaggct ctggccctcg
     1621 cggatcagcc gcacgccgcc gtccttgttc tccacccgca tggagctgcc atcgagcgtc
     1681 gtcgtcccga ggatcggctc cttgcgcgtg aagagcatcg tggtcacccc acccgtgatg
     1741 tccagggggt tgctcgtggc cttgagcgtg tagttgtaga cagcgaacgt cgagacatcg
     1801 acgtcgaagt cgacgtactt accgcggacc ttcaaaatgc catgtgaggg caggctctgg
     1861 ctgggaacct cgatcctgtc ccctcctccc ttggccttga tgacgagggg tgtgccattg
     1921 ggcagcgtca gggcgaagcc gcctcccgag caggcggttg agttggcggc gtgcgcggtg
     1981 ggaactccga acagtgcaca gactccaagc gagagcagcg cgcccagggc acgcagtcga
     2041 gtcgagagat gcatggtgtt ttttccgggg gattgttgtg agtggtgctg aaacgaatac
     2101 cgcgatggct ggatccagcc gtggtcagac taacgcctgt ttccggcgca tacaaataca
     2161 atcgaagaca aaagcaatgg atgagctggt ggggtgctgg ctccggcgga gttcatttcc
     2221 gtcagggaat ggacctggag tgcgcggacg agcaccggtg tgggtgcttc gtcggcatgc
     2281 tttggccagc ttggtgcgta tgaaagatgc ttaccactca gcaaccaaga agtaggggga
     2341 ctcattcggt ttctgccaag gggggctcgg aacgagtcct ctgacacctt cccggagcga
     2401 tatgtcagaa ggacggacga ggagaagagg ggtccattcc gtcccccgag gaacacatgc
     2461 gctacttcga ggacttccag gtcggtcaga tacacgaact cggtacgtac gaggtgacgc
     2521 gcgaggagat cctcacgttc gcccgtcagt acgacccgca acccttccac ctggacgagg
     2581 aggcgggcca acgctccatc tacgggagca tcatcgcgag cggttggcag accgcggcca
     2641 tctgccaccg gttgctggtg cgcgccgtgt tggaggactc cgccagcatg ggctcgccgg
     2701 gcctggacga gctgcgctgg ctgcggccgg tgcggcccgg ggacacgctc tccgcgcgca
     2761 tcgaggtgct cgaggtcacg ccctcgcgca gcaagccgga tcgcggcagc gtcaagacgc
     2821 gcatggaggt gcgcaaccag cagggcgagg tggtaatgac ggagctcgcc agcgtgctct
     2881 tccgccgcca acccgcgacg acgtgagtcg gttcggggcg gagtgggagg cgcgggggta
     2941 cacatgttgg aatggggaga atggaaatga ttgattacac gagactgggc aagacggggg
     3001 cggaggtgag ccgggtgtgt ctcggggcca tgacgatggg aaccctcatg gacagggacg
     3061 aatcattccg cacgctggac ttcttcgccg agcagaacgg aaacttcatc gatacggcga
     3121 actgctattc ctggtgggtg gggaagggag agaacgtcgg ggatgagagc gaggtcatgc
     3181 tcggggagtg gatgcaggcg cggaggaacc gggagcgggt attcctcgcg accaagtgcg
     3241 gcgcccgcat tcccgactcg cgggccatcc gcgacgcgga tggaaccccg cgctgggccg
     3301 aggtcccatc gaactacgag ggcgcctcgc gccgggtcat cctcggggcg gtccgcgaca
     3361 gtctccgccg gctgcgcacc gattatatcg acctctatta tgtccatgtc gatgaccgca
     3421 agacgccact cgaggaaacc ctcggcacga tgaatgagct cgttgcctcc ggcgtggttc
     3481 gccatcttgg atacagcaac gtccgtacct ggcggctcga gcggatacgc gcgatctgcg
     3541 agcgcaacgg ctgggcgcaa ccggtcgcgg tccagcagga gtatagtttc ctgcggcccg
     3601 ccgccggcgc caatctgggc atcgcggttc atgcggatga cgagttcttc gactacctcg
     3661 cggaggaccc ctcgatgacc ctgctcgcgt actcaccctt gttgaagggt atctacgcga
     3721 gcagggaaaa gcggctcgcg tactacaact ggcccctcta cgacacgccg gattcagccg
     3781 cgcgcctcga acggctcgag gtggttggaa agcggttggg catcgacggc aataccctgg
     3841 tgcttgcttg gatgctgcac cggaagccgg cgatcattcc ggtcgtgggt ggcagccggt
     3901 tcaaccattt ccgggagaat ctcgccgcgc ttgacgttcg gctcgatcgg gaaacgattg
     3961 attacctgga gggtggaagc gcgggggcat gaagccaggc cgcgtctcac ggtgcctggc
     4021 gcgcggtgcc cgccgcatag cgcttgcgtg acctacgccg agtaccccga cgacgagcgt
     4081 gaggcggtgg tcgccgccca tccccggacc gagcacttca aggaagacat catccaggcg
     4141 ttctacgatg gcatcaagca caagccgcgg accaccttcg gcaacgtcaa ggcggacgtg
     4201 atcgcggaca aggagccgct gttcatccgc ggcaacttct gccgtgtcat tcgggaatcg
     4261 gcctggcgag ggtagccccc cgggttcttg gaacccgggg ccctttgtct tggtgcggct
     4321 gcggcctggc tcagcggggc ttgaagctct tcgccgcgta attgaaggaa tggaagctga
     4381 acccgaacgc gatgccggtg cagtcgggtc cggtgtaggc gaggatgcgg tcaccgctga
     4441 tcatgttcag gccggcccag gcgtcgaatg gcaggttggt gcactcggac gacacggtct
     4501 ggtagttgat gtacgggctg tcgaaggtct tcccggccca gaaggtgaga cccgagctgg
     4561 ggatctcgaa ctgctcggag gtgggctggt cgacgctgac gtcggcgacg agcgcggagg
     4621 aagagaggag gccgacggcc agggtcttga acatgggatg tattcctttc gttggagtgg
     4681 cttcattgcc gctcgagcaa ggcgaccggg atggataccg gtagcgccca tcttcctctg
     4741 attaccgttt tcggcacgga aagcaagctt ttggacgatg ggctggagca cacgagcaag
     4801 aggtgctcgg ctgccattga gtcaggccag atgcatgcag gaatgaatag cgaatatgca
     4861 aagctgacta tggttgagcg cgccgcgcgg gtggatactc gatgggggga cggcgccgcc
     4921 tccctctcat tcattcgcgt tcgaggacgg tccccgaacc gcgcggaact cagcgccgct
     4981 tccggaggcc gtagtccgac agcccctgct cgaaacgctc gaaggcgcga tggataccgg
     5041 cgatggtctc ttgaaacgat aatctggttt ttctcagtgg ctgttcgtgc catgattcgc
     5101 accttttccg tgtggctttc ggagacccca catcgcaacc gagttgcaga ggaagagaga
     5161 tgcgtcggtt tcaccattcc gcgtcgcgtt tgtgtctgtt cctgtcgcta ggcatcatca
     5221 tgggctgcac ccagggcacg cccgctgtcc atgaatccag gtccaccgcg agtggcctcg
     5281 cgagcgaaat cagtattttc ggcacgagcg tgtcgccctc ctcgctcgag gattcggaca
     5341 cggcttccgt cgagctgggc gtgaagttcc gctccagcgt ccccggcgcc gtcaccggca
     5401 tccgcttcta caagggcagt gcggccaacg cgggcacgca tgtcgggagc ctctggaacc
     5461 gcgccgggca gcggctcgcc tccgcgacgt tcaccaacga gaccgcgacc gggtggcaga
     5521 cggtgcgctt cgcctcgccc gtgagcatca cggccaatac cacctatgtc gcctcctacc
     5581 tcgcaccgcg cggccgttac tccgcgacgg tcggctactt cgccgggcag gacgcgacga
     5641 atggccccct caccgcgctg gcgtccgggg tggatggcca gaacggcgtc tatgtctatg
     5701 gaagcggcgg cttccccacg cagagctatc agaacaccca ttacttcgtg gacgtgctct
     5761 tcctccccac ccccgacacg agcgctccct ccgctccggg ttcgctcgtc gccaccgcct
     5821 ccgctccggg gagcatccag ctcacctggg acgcggccac ggacgatgtc ggggtgacgg
     5881 cctatctcat cttccgtgat ggcgatgagg tcgcctcggt gtctgggacg acgcgcggct
     5941 acagggacct gggcctcgcg gcttccacgc tctaccacta cacggtgaag gcccgggact
     6001 tcgctggcaa tgtcggcgct gcctccaaca cggcctcggc caccacgtcc gaccaacagc
     6061 cacctgacgg gttgaacctg ccccgtgttc cctgggaggg cgggcctgcc ttctacgcac
     6121 gcttcccggc catggcgggc acgccctggc tgtcagagga cttcttcccc atcggctact
     6181 ggggagcgta cacggacgaa gagcggcgca tcgccaccga caaggcgcac ggcatcaata
     6241 ccttcctgga gacctatgcc ggcaacggct cgtccgcggg atggatgcgc cagcatggca
     6301 tctggaacct cgccggctcg ggtctgggcg gtgaggcggt gggaacgacc ttctacgatg
     6361 agacggatat gtgggctgga cccggatggg atccgtggac cggcaatgtg gccacctatg
     6421 acgtgtgcat cccggacgac ccgcgccgct gtggcttcac catctacaac gcgctgtatc
     6481 aggagctgaa caacccgaat gccttcatct acgcgaacgt gggcaagggc gcgctgatgt
     6541 ggtggtcgga cgagcagcgg gagattggca tcaacggagc ggatggcccg gatccgaggg
     6601 cgaactggcg gttcggcatg gtcaccggcg acatctactt ctacacggat ggcaacattg
     6661 gcggtgaggc gcccaactgg ttcggcattc ccgcgaacga ggtgcgccgg gccgccaact
     6721 acggtgaaat cctgatgacg aacctgcgga gcgcgtcggg cgccggcaac aatggcgagc
     6781 cgcgcatccc gctgggcgtc atcgtggagc ttggcggaca ggcccagggc agtgtcatca
     6841 ccgccgacca ggtggagggg gcggtgtggt cgacgctcat ccacgaggcg cgcatgctcg
     6901 ggtacttctc gcacgtcttc tccgactcca ccgcgaaccc attctccacc gatgtcctca
     6961 acgactcgcg ggcggagtac caggcgacgc gcgagcgcgt gaagaagatc aacgccgagg
     7021 tgaccgcgct ggcccggatt ctcaacaccc agtcctatgt gtggcagttc aacccgagcc
     7081 tgagcacgat gctcaagtac cgcgatggcg cggcctacgt cttcgccatg cagaagcggc
     7141 agttcaccag cgggacctac accttcaccc tcccggcgga gctccccgcg agcgggaccc
     7201 tcgaagtgct gggcgagaac cgctccatct cctactccgg cggcaggttc accgactcct
     7261 tctcggcgga gtactcgcac cactcgtacc gcatcccgga ctgagcaggt gacgcgggcc
     7321 ccgcggcgga acggtctccg tcgcggggcg gctttttcgg gcgcgtgggc ctgcttcgcg
     7381 ggcgacggct cacgacgcga gcgcggactc cggctcgaag tcgatgaagc cggggttgag
     7441 gatgcccttc ggatcgtagg tgcgcttgag gcggttgatg gtgggccacg cctcgccgaa
     7501 gtgcatgcgc cagcgcgccc gatcgaagtg gacccaggtg cccagatgac gtcgggcgcc
     7561 gacctccatt cccacgtcgc tcagcttgct catcacggac atcatgatgg ggagtccttc
     7621 ttgcgtggtc gccgggcaga tgctgagcat cgccatgatt tcttcccggg gcatctggag
     7681 catcggcacc tgggtgacac gccggaacgc gggccacagg cgcatgggtc cgttggcgct
     7741 tccgagcgcc gccgggggga tgcgccggat gcacagctcc aggaagggct ggacgcggga
     7801 ccagggcatg aacgtcacca tccagggata ggcctcgccc gggagcgggg gcttctcggg
     7861 gttgctcgcc tgcgagacga aggccgcggt gggcacgtcc tgcgtggaga tgtggcgagc
     7921 gaagcgcagt ccggcgagca gccgctggcc gtcgcggtcc tccggggcct ccctctccag
     7981 cgaagcggtg atgacacccg tccaccggac gccctgtccg tcgggcttct gctggagggc
     8041 gcagtcgagg tggtcggcct cgtccctcac caccagggtg cggctgtcct ccagccaggc
     8101 cccgaggtcg tcgtactcga gaacgtaggt cctcacggtg gagtggtagc ggcgcagttg
     8161 gtagcggatc ttcgtcatga ggccgaactg ccccatgccg ccacgcacgt ggtcgaacag
     8221 ctccggctcc tgctcgcggt tgcagcgcag gtgctcgccc gtgccgatga cgacctccaa
     8281 ctccacgcaa tggtcgagct gcgctccgta ccgcacggac gccgtacccc agccgcaggc
     8341 ggagagcgtc cctcccacgg acgcgtgcgg gtagctcgtg agcaccggcg gggtgagtcc
     8401 gtgggccgtc gaggcggcga ccacctcccg ccagagcact cctggctggg acacgaaggt
     8461 ccgcgcgtcc ggggagatct cctcgagccc gcgcagcgcc ctcatgtcga tcacgatgcc
     8521 cccctcgcac agggactggc cccgcatcga gtgacccatg gcgcgcgagg ccacgggaag
     8581 gtcccgcgcg tgggcgtagc gcacgatgcg cgcgacctcc tcggcgtcac ggggccgcgc
     8641 gagggccgct ggcatccggc gcacggtgcg gccaaagtcc tgggagtagc gctccaggac
     8701 ctccggctcc tccgtgactt ctccttcgag caggcgctga agatccctga ccaggctggt
     8761 gcgcgtcttc tccgacatca tgtctctcca cgagcaggcg tctgcgtggc gctcgggggc
     8821 tcgcgccaca cgggcgcgcg ccgtcggccc agctcctcca ataggtgggc ggcccgctcg
     8881 tggccgccgg cccgctggaa ggtgctctgg agccgggccg ccgcggtccg cagctcctca
     8941 cgcccgagca gctcccgcac catctccagg aggcgcgcgg gctcggcctc gttgtcctcg
     9001 aggtgcaggc ccgcctggac gcgcacacag cgctgggtga tatccggctg ctcggcaccg
     9061 cccccgccgg gaatcagcag cagcggcagc ccgtgggtga gcgcgcccag cacggacgtc
     9121 gtcgtcgcgt tggagacgac ggcgcgcgcg tggggcagga tggctccctg ggacacgtgg
     9181 ggtcggacga agaagttttc gggcacctgc tccacctcgc ggtccatgcg cccgacggcg
     9241 gccaccacgc gcacgggctg ccccgtgagt gcctccacca ggctgcgcca gaaggcccgc
     9301 ttgttgaagg cgcgcccggg ctgcacgtag agcaggggct cgcccgactc ccgcgccgcc
     9361 gccagccacg tgtccagctc cgcgtcggga ggacccgggg gctcccagag acaatccccc
     9421 acgaagtgca cctggggcgg cagtgtctcc acgttcccct ccagctcggg cacgctgcgc
     9481 agcaggaaca gatctccgac gaggggactc tcgtggatgt cgtgcgcgcg ccgctccatg
     9541 ccgagcatct cgcgcaccag cgcgtaggcc aggtagaagc cccggtagcg ccgcaccagc
     9601 ttttcacgct gctcggcctc ctcgggagga ggtccgtggg gccacaggta gctggccatc
     9661 cccacggtgg ccacgggcag ggccttgcgc tccgcgacga cgtacggtcc gagcgcgagc
     9721 tgctgcgtca cgaggacgtc cgcggggaag cgctccaggg cccgctcgac gtggcggacc
     9781 tggcgcatcg tgtccatggg gtggccggag atctccacga ggaagctgct gccatccggc
     9841 tcgccgcggg ggatgcgctg gaagcccgcg cgctccacca ccccggccag tttgaggtcc
     9901 gtgacgaagg cgatctcatg cccccgacgc cgcagggcct cggcgatccc cagggacgag
     9961 aacaggaagc cgaagttgtc gagcgagcag aagaggtacc tcatggctca cgggctccga
    10021 tggggcgcgg cggctcgaac gcgaggaggg atgggatgcg cgatggctcg gcgagccgga
    10081 gcagcgcgta gccgatgcca gccagtcccg tcatgaggcc gggggtctcc acgcccgtgg
    10141 gcacgccaca gagcagtccc acccggtcga agctggcgac gatggccccg gcgagccggt
    10201 cgcactcccg ttccagctcg gagtccgcca acgtccgcgc ggcgagcgtc agcacctcca
    10261 ggttgccgag gtcgccatgg cacagcgagt ggttgccgcc gaagccctgg acccgcgtgg
    10321 tctccaacgc cacccggagc tcttcgcgca cctcgggtgt atccaggtag ggcagcgaga
    10381 gcagccgcgc caacccgatg cctggagctc catgacagag cgtggtcatg aagcctccct
    10441 ccgcggcgac ggcccggaga tccctccagt tgcgtcgctc gggggagaac tcggcgcgct
    10501 cgtacgcgag ggcccgccgc gccgcctcct ggaagcgggg gtcgcccgtc tcggtgccga
    10561 gcgccagcag gaaccaggcg atgcccgcgg ctccatgcga gaagcctgtc aggggcagag
    10621 ggcccagggg ggtcacccac ccgagtccct tctccgtctt gtgcgccgcc gtcaacagac
    10681 gctccccaca ctggcgggcc agctcgagcg cttggggcga ggggcggcag cggtgcagct
    10741 cgagcatgag cgtgccgcag cccgcgactc cggtgaagac atcgagggac ttgtcctcgg
    10801 cgatgagcat cctcagccgc cgggacagca gtgcttcggc ctcgtcccac agctcgggct
    10861 ggttccagag ggcccccagg tgcaccaggg agtggatgac gcccagatct cccgtggccc
    10921 ccaggttgcg cggggagaag gagccacccc ccgttctccg gcgcaccgtg gacagggtct
    10981 cgcgcgccag cgccgtgtgc cgtggctggc ccgtgaggtg ccccagatag gccaggaaga
    11041 gcatgatgcc ggacaggccg ctgtacaggt ccacgtccag cgacgacagc gtccagtagc
    11101 gctcgcccac cggggtgagg ccgagccatg aggcgtccga ctgaccccgg aaggccagtg
    11161 cggcgagccg gtctccgatg gcctccgcct tttccaacag cggttcccga cggggggcct
    11221 cgtgcgacac actgagcgcg tagctcggca tccgcccgcc ccccgccatc accgacagcg
    11281 aggtgaagga ggcccggatg aaccagagct gctgagtcag cccctcctcc gacagccgct
    11341 ggatgcggtc gcgagagagc tccagtcccg tgcgggggaa gaactccgcc agccgctggc
    11401 ccgagctgct ccacacatcg cgcgagcccg gccgggagcc gaagaacggc acgtcgaggt
    11461 gccagagatc ctcgtgctcg tggggaatca gcggtcgggt gtaggggatc tgatcgatcg
    11521 tgccccagag ccgatcgagg aaccgctcca ggtccaagcc gtcgcgcagg tggtccgggt
    11581 ggcagctctc ccgctccagc aggtggtaga agtacgtggg ccgcaggatg acgcgcgtct
    11641 cgtccggggc gaaccgctcg aggggcccgt cgggggcgag gagcgcttcg cggtgcgcga
    11701 gcagcagccg gtacatctgg gagaagccct cctggaaggg ctcgttgaag tccaggaagt
    11761 tgacgtcctc gcccttcagg gtgggccggt tggcgctggc ggcgacctcc acccgccgac
    11821 gcgtcatccg catctcgtcc gtgccggtct gttcccagac ctgggcggcg cggggggtga
    11881 gctgcccggc cgtggagccg agtgcgctga agtcgattcc ctccgagccc tctcccgacc
    11941 agccgcgctg gggcagcagt cccatgcgca tcaccgagtc atccttcgcg cgctcggcca
    12001 gatcttccgc gccccgcgtc tcccccacgg cgaagtgcgc atggaagagg gactccaggt
    12061 ccaccaggca ggggtgctcc cccacggcga tgatgttctc gaagtggacg tctgtcgctt
    12121 cgagcgcgta catcaaggcc agccagctcc ccagccgcgc gtagaagcgc gccacctcct
    12181 cgcgcgtggc gcaggagcgc tgcgccacga actccatcca tccgtacgcc ccccggtcga
    12241 tcgcgcccac ggggcgcagg tgtggtgcct cgctcctcgc gttgagccac ccgaccagct
    12301 ggtggaagtg cacgtccgcc gccagcgagc gcggtttgta gacgacgcgt gctcccgagg
    12361 cgaacgtgag gatggccacc gtgcggcccc cgcggtgcgc atcgcccttg ccgagctcac
    12421 aggcgctcag ccgatccagt gcgagtggga ggccgaggct cgcgccgagt tcccggtggt
    12481 ccgccgccag ccgctccagc atctccaggg aggagatgaa ccagttgtcc gcgcagatga
    12541 cgagcctgcg agccaggacg ggatattcgg cgaagagggc gagtgccact tcccgctggc
    12601 gcaggctctc ggtgaagccg cggaaccgct cctccgcgtt gtctccctgg agccgttcct
    12661 cctcgcgggc gacgttcaac tccagcgcca gcgttcgcgt cagttgcgag agcagccgct
    12721 tgcagaggaa gggcatgcac agggtcgccg cgctctctgg ctcgaaaggg gcgtccgggt
    12781 gccgtgtcac caccgcgccc agggctcgca ccaggcgggc ccggctctcg tcgatgagcg
    12841 gctcggcgag gaccaggaag gtgggcgtgg cgagaggcga tccgggaatg gcccgcgcgg
    12901 gtggctccgc cgccaccggg tgcgtgtaga ggcgggccag tcgcgtctgc cattcgggag
    12961 gggggccgag ccgcgccgcc agcgtctccg tggactcgcc gagtagctgg agcagttgct
    13021 cctcggtcgc gccgtccagc gcgagccgtt gcgcgaagag ctcgtcgcgg tccaggggtg
    13081 ctcgggagcg ccaccgggca agtcggcggg tggcccgggc cttgtccttc ccggcttcgg
    13141 ccgttgtgcc aggcggtggt ggagggccca ggtgccggac acgctccgac aaggtcgtcc
    13201 ccttgtgcca gcccggacct tccgggttca ctccctccac gacctcagac gcctcggggc
    13261 gcatcgtcat caagcacgta tccttgctgg gcgtcactgt agtgcagcca gcggtgcagg
    13321 gtctccaggt agaccttggc ctccagcggc ctgccaggtt ggtggacgac cttgaggtgg
    13381 ctcagccgcc gcaagaagag gctcaggcca cgtccgttca gctcgcgcgc gatgcggctc
    13441 agttccttcg gccaggactc cggctggctt cgctgctgca tgtggcccac ccaggcgagg
    13501 atcgcctctc gcttgtcggg caatcccaat ccccgctcga cgaggtgtcc cagcagcgtc
    13561 tcccagcggg gctggctcga gccgatgggt gcttggatgg cgaactcgaa gccgaccttc
    13621 tcgcccaggg tctcgcccac gtcgatgtcc agggagagct ggtccgccag ctccgggagt
    13681 cgcccgagcg ccgcctccac ctcaccgggc tggccgggcc agccgatgcg ctcgagataa
    13741 gacagccacc gaggcaggct cgcgcccgac aggcacaggc gcaaggcgga cgtgccccgg
    13801 gggaacatga cccccaccga gtagatccgt gcctctgggg gcagcgcttc gtaacaggcg
    13861 gcgagccgtc gccgggtgct ggcggggagc ctgtcgccga gcagcaggtc caggccccgc
    13921 tcggcgaatt cccgcgtctg gcgcaccggg cgtgcgaagt ccatgaagac gcagggctcg
    13981 ggcacctctg gcggcgggtg gtcgaggtcg aactcgagga agacatccat cacgcccgtg
    14041 ttcagcgcgc caccaggctt cctccactcc cggcagaagt ccccgagtgc ccgccaggtg
    14101 gggtggtcgc gtgccacttc agggagcgtg ggcggggtgt cgccaaggcc gagcaaggca
    14161 tcacaacttc cgtccgtcag cagcaggcgc ggcagcaggt ccactcggga cgcaggggag
    14221 ccgagacggc actcgaactg gaaacccagc acgggcggca gcatgcgtgc gatgcggcgc
    14281 atgtcctcgc gcactgcctc cgaggcgagc cggacatcga gatgggagtc gaccaacctg
    14341 aggtttactt ccatcgactc gtgcatggtg ggacaggtcc tcgaggcgac ttccgcctcg
    14401 agagggtggc gaggcggact ggaagacggc tcagctcgca gtccgctcgc cggggttgtt
    14461 cgtggagggg gaattacaaa cgactagcag ctttcccaac agcacgacga cacctgctta
    14521 ccgccagaca gcaggctgtc cagggcctcg tcagagagct ccacgatacc ggccgggttg
    14581 gccggcagct gagcgcgctc ctcctcggtc agggacagac ggaaatcctc atccttccac
    14641 gcctggatcg tcttcttcat gtgttgctcc ttggttctcc ttgcctggaa ccactccagg
    14701 aagggagctt cgcggcgtca ggcccttgct cctggctcct gcgccagatc cgtttcgccc
    14761 cgggcctcgc gtggaggcgt gggggtcgca tccgctgcct ggccacgggc cagggcggca
    14821 taaagtccat tgcgcttcat gagcgtgtca tgcgttccct gctcgacgag ccgtccctga
    14881 tccagcacga ggatgaggtc cgcgctgcgc acggtgctca accggtgcgc gatgatgatg
    14941 cgtgtgcatg acatgatacc caggttcgcg tccacctgcg cttccgtggc ggtatccaga
    15001 tggctggtgg cctcgtcgag cagcagcagg gtcgggcgcg acgccagtgc gcgcgccagc
    15061 gccagccgtt gacgctgacc gccggacagc cccgctccac cctcgccgat ccacgtctcg
    15121 tggcgcatcg gcatccgctg gacttcctgc tccagcgccg cgaggcggag ggcctcctcc
    15181 acctggccca gtgcgatccc gggtgcgttg agcgagacat tttcccggag cgagccgctg
    15241 aagagcagcg gctcctgcat caccacgccg aactgggcgc gcacctggcg cacgtccagc
    15301 tcccgcagcg gcagaccgtc atagaggatg cgtccctcgg tgggctcgag gagtccgagc
    15361 aggaggctgc ccagggtgct cttgccgcag ccgctgcgac ccaccaccgc caccttctgt
    15421 ccgggctcga tggtgaagga gaggcccgag agcaccgggg cgctccccct gccatagcgg
    15481 aagcccacgt tctccaggtg gatgtgcccg cgcagccgcg gagtgggccg ggtcgtcacc
    15541 ggctggggct ctggctcggc ctcgagcaca tccaggatgc gcgagatgtg ggcccccgcc
    15601 aggtgcaact gctgcccggt ggtgaccagc tgcgccagcg gcgtgaggac ggcggcggcg
    15661 atggcgttca gcgccagcat cgtgcccagg cccatcttcc cgtcgagcac ctggattgct
    15721 ccgagccaca gcagcgccag cggcgcgaag gtgcgcaggg cgttgagcag cgcgttgatg
    15781 aaggccgtca gatggccccg ctccagcgac gcgtcgagct gccggtggaa cagtgacgac
    15841 cagaagcgca gcgtcagctc ctccgccgcg gaggccttga ccagggccat tcccttgaag
    15901 gcctggacgg tgaagctctg gaactcggcc tcggtggtga ggccacggtt gagcagctcg
    15961 cgcatgcggc cggccgtcat gagcaccagc atcaactgga gcacccccag gccgaacacc
    16021 accgcgccga agagcggcgc ctggaaggag aggatggcga ggtaggtgac catcagcgag
    16081 ccatcgagca cggtggtcag cgtctggttg gtcagcacct cccggatcat ccccgcgctg
    16141 ctcagccgcg cgagcagatc cccgctggtg cgctgcatga agaagcggaa gggcagccgc
    16201 agcaggtggc ccagcattcc gagcaacaga tgttcatcga agcgtccctt gagggacacg
    16261 agcagcacgt tgcgcaggta gcccgtcacc gcctgggaga gggtgacggc caccatgccc
    16321 acgcccagca gggccatcat gctgaagccg cgcagcggca ggacatggtc caccagcacc
    16381 tgggtcatca acggcactgc cagccccagc acctgcagga gcagcgaggc ggccaggacc
    16441 tggagcgcca gccccttcac ggcccggttg cccagcagcg ggcgcaggaa cgtgctccac
    16501 ggggagggca ggggtcctcc ggtcatgaac tccggacccg gctcgaacgt cagcaccacg
    16561 cccgtgaagc ccttgctgaa ctcctgggcg gacacgtggc gccgccccac caccggatcg
    16621 aagagctccg cgcccttcgg cgaccactgt tcgatgacga cgaagtggtt gaagttccag
    16681 tgggcgatcg ccggcagccg gatctgcccg aggtgctcga ggtcggtgga gaagaccttg
    16741 gcccggagtc ccagctcgcg cgccgcatcc acgaacatgc ggggccggac tccgtcccgg
    16801 gtcacgccca gccgatcctg gcactccgcc acggaggtgg gccgtccggc gtgggcgagg
    16861 atgcgcgcca gacacgccgc gccacagtcg gtcgccgtgg cctggagcac cagcggcggg
    16921 cggggaggaa agagccgccg ccacaagctg ctcgcaatag aggagggagc gcgtccagat
    16981 ccggtcatgg ctcacccctt caggaaacgc gcgaggatgg ggagagacgt gagaaggcgt
    17041 tgctggccca cctcgacttc gacacgaaag gtgctgccga gccaatccgt cgcggagagc
    17101 ccctccgtcc caggcggcgc gaacacggcg aaggcgcacg cggtgggtcc gttgggacct
    17161 tgtctggagt cgcccttcag cccgaagcgc tccagcgccg cctccggact caccacggac
    17221 tgctccacct ccttgatatg gctctccagg cgaacgccct ttccactcac gtccaccagg
    17281 agtcgctggc cggccgccag gcgcgtacgt gcctcgggtg gaaagaaggc cacgagcatc
    17341 agcccttctc cgcccgctcc aggcgatggc gccgccggca cgacgatggc cgtgcccgac
    17401 acatgtgccg gaacgggaac cgccacgagt gccacgccga aagccacact cgccagcgag
    17461 gtggcccaga gcagcgcgag ggtccgggac gaggtgtatt gggatgcacg gaagtgctcg
    17521 cgggcctggc ggtgggccgc gatggcttcg gggcggtaga caacctggtt cgcggccgac
    17581 gttccgttct caggtgcgcc ctcggccatg tacgaagcac ccctttcatg tttcacgacc
    17641 ggaacgtcac ggtgcttccg tggagattaa gtcaaaaatc ggaaactgag aagagcactc
    17701 cgtgctcttg accgggctgg aaccgttacg gcgtgtggcc ccccctggtg cctccgcctc
    17761 gggcacatct cacgaggttc cacggcgtct tcgctccagg cgccagaccg cggccatttt
    17821 tgctccccca agcaggtgtg gaggcgaggg gggagcccca ggcatcgaag ccatctttcc
    17881 gggcccgccg gcctcctggg gccggtgggg cgggacgcca gtgacttcag ttcaccgggg
    17941 tcgggccgct gtccctcagg tgcgcgttca ggaagccgag catccgcgag taggcctcca
    18001 cctcgttctt cttcttggtg aagccgtggc cctcgtctgg gaagatgacg tactccaccg
    18061 ggatgccgtt cttcttcacc gcctgcacga tttcatccga ctcgggctgg atgacgcgcg
    18121 gatcattggc gccctgtagg acgagcagtg gcttggagat cttctccgcg tggaagaggg
    18181 gtgagatgtc gcgcagcatc tgctcctgct tcgccgggtc gccgatctcc ttgtagaggg
    18241 cctcacgctg gctctcccac cagggcggga tgctctggag cgtgcgcagc cagttggaga
    18301 caccgaagat gtcgatgccc gccttgaagg catccgggtg gaaggcgagc gcggccagcg
    18361 tcatgtagcc accgtagctg ccaccggcga tgccgatgcg ctcggcgtcc acgtagggca
    18421 gactggccag gtacttccgg gcctcgacgc agtccagcag cggctcgtgg ccgtgcttct
    18481 ggtcatccgc ggcgaagaag ctcttgccat agccggagct gccgcggttg ttgatgccca
    18541 gcacgacgta gccgtggttg acgaggtatt ggatgaccgg ggagtagccc ttgcgcgtct
    18601 gccccccggg gccgccgtgc acccagacaa tggcgggtgc cttggcgtcg gcggtggcct
    18661 gatgcggttt gaagaggatg ttgggaatct ccatcccgtc gaaggacttg aagcgcacca
    18721 cctgggcctc gacgagatcc tccgggtcca tctgcttgtt cctcgcgtcg gtgagacggc
    18781 tgaccttctt cgtgccgaag tcgtagacga agaggttcga cggggaacga tccccattgt
    18841 ggtagaaggc catccgcttc tcgctgtccg agatgcgcac cgaggtgatg tcccccgcgg
    18901 gcagctgcgg cagctccagg agcttgcctg tcttctgatc atgcacgcgg atgacggtgc
    18961 ggccgtcctc gttgatggcg gtgacgcgga agccgccctt gcgcgagaag tacgtgtaca
    19021 tcacgtccca gtcggcgcgc tccacctcct ccatcactcc ggtcgtcagc gtgtagcggg
    19081 ccacgcgctt gaactcggag ccctggttcg tgaggaagta gagggcgctg gagttcggat
    19141 cgaaagagct cgcctggaag aacgcgtcgc cctggtgcgg ggtgatgtgc ttgagttcct
    19201 tcttctccac gtcgtagagg tggatgtccg cgtcgttggt ggtccgcacc ttgttgaagg
    19261 cgatccacct tccatcgggc gagaccgcct cgaaggagag accggtgtcg ttctggtaga
    19321 cgagcgtgcg cgcatacgtc ttcgcgtcgt agcggtagag gtcgaagaac cgcgcgtcgc
    19381 gctcgttggt gaggacgtag aaggccgagt cgtcatcgct ccagctcacg aacatggcct
    19441 tcagcttgtc gccgggcgag aggtcgcgct ccttgccatc cggagtgcgc acgaagaggt
    19501 ggttggcttc gttgccaccc tggtcgcgcg tgaagaggat gcgctcgtcc ttggggaaga
    19561 agctcacggc gtaggtggag tccgtcttcg agtgggtgag cgccttcgcc ttcccgccac
    19621 tgaggggcag ggtgtatgcg ttgaagatgc cactctcgtt ggaggaaaag aggacgcgct
    19681 tctcgtccgg cgagaaggag gcgccggaga gcttcgtcgt cgtcatgaac tgctcgacgg
    19741 tgtactgctt ggagggccgg gggacagccg gggccggtgt cgcgttgggc gcagcgagtg
    19801 cgagggcggg cacgagcgtg gccgcggcca gtactcgcac gagggtggac cggaactgca
    19861 tgcattctcc gcgttggtgg gaagtggggt gaccaacacc gtacgaaaca ccctcctcct
    19921 gatttcccgc cagtcccccc ctgagaatct tcctgccttc cggtcttcga cgctgcggcg
    19981 ataggccagc gccactcggg cagccggcac cggctcgaaa ccagggaagt gcggggatga
    20041 acagggcccc agtgtattcc ctatcccgta ggcgataaat ccctgatggt ttcattcact
    20101 acaaaccagg agtttgcaat catggacaga ctgcgtgcgg cggaggtcta tgtggccgtg
    20161 gtcgaggccg gcagcttcag tgccgcggca cgggcgctgg tgatgaactc gggggcgctg
    20221 agggggctgc cgacgccgtg cacccaggcc aacgcgcgtt cgaataaaac gaaacccttc
    20281 cgtaaggatg accgcccggc cggcatctaa tcagcttgaa cacgggacgg atcatggacg
    20341 cgcgagagga tcaggacagg gctttcgtcg actggctggc gccgcacctg gcgaccttgc
    20401 gccggatcgc ccgcgcattc gcgcccccgg aagaccaata cgacctgatg caggagctga
    20461 tgctggcggt ctggaacgcc cgcccgagct tccaggcgcg cagcgccgcc acgaccttcg
    20521 tctaccgcgt ggcccacaac acggccctga cctggaagcg cggcgagacc cgccgtcgcc
    20581 gccgacgcga ggcaatcgag gtcgagatgc tgtggcgggc cgaacaggat cgcgccgagc
    20641 cggaggcagg cctgctggag cggctctacg cggcgatccg cgtgctgccg ccgctggacc
    20701 ggtcgttgat cctgctgtcg ctggacgggc tggcctacgc cgagatcgct cgtctgcacg
    20761 gcctttccga aaccaatgtc ggggcgcgcc tgacccgtat ccgccggcgc gtcaccagcc
    20821 tcgtggaggg cgccgacgat ggattttgac aagctcgaag ccgcctggcg ctcgccggcc
    20881 aacacgcccg acgaccgcgc ccaggcctat ctgatggagg aattgatgcg cacgctgaag
    20941 gcccgccgtc gccgcgaact cctgttctac gcgattccgg cgacggccat gacgatcttc
    21001 acggccatca cggtccaggc gatcgccgcc gggcggatgg atgtcggccg ggagtgggcg
    21061 tcgctggtca tgctggcgat gtgctggctg gtgctggcgg cggtgctggt cgtcggcttc
    21121 ttgctgcgaa gtcgaggtag atccggaggc tctccggtgc gggacaccct caccaccatg
    21181 ctggtcgcca atcgccgggc ccgcgccaac gtcaagatct tctggatgat gctgccggtg
    21241 ttcctcgcgc cgatgctggt gggcgtccaa cagctgcgcg aggtcggcaa ggccaccgac
    21301 cgcgacgcct ggcagatgct gttcgtattc ggcgtggcgc tggtcgccag cgtcggctgg
    21361 aacacggcgc ggtacgtctg ggtgctgaag cccgagcagc ggcgactgga ggcgttgctg
    21421 gcggaatacg aagcctgacc tttaccagcc gcatggccaa caccggcgcg aacgcgcggc
    21481 gaggtgtctc cgcttccgcc acctgtccgg actgagcccg tagaggacaa gggcaccctg
    21541 atcgttctcg caccagagcg tctcagggca tcgaacccag agcacctgtc gctcggtcgc
    21601 ggggttcagg aggtattgga ctcgaagggg ctacttcgcc ccgtactctc atagagaaac
    21661 ctcatgactc cctccctgga ggggggcagc gccggaagct cctcgatgtt gtctacacag
    21721 ccacgttttc aggatcagtc gcgaagagcg catgaaagag cgtggtagca ggcggctcca
    21781 gtagatccac gatgagcggg attcgagtct cggcgatctc gcgaggaagg gcctcagccc
    21841 cgaacatcgc ctcgatcttc ctgccaacga cctccgcgag tgcctgcatc tcgggcggaa
    21901 gcggatcgaa aaagaccttg gcggcgatca cgtctttacc tttgtagtcg tactgcaggc
    21961 catagaccgt atagataggc gccaggatgc tgaggcagcc gacaaccccc cagcggcgct
    22021 ctcgtggccc atcctcatga ctcgcctcca cggactgccg atccgtaaac acggtacagc
    22081 ggaaacagga agtagaggtg gccgtggcat gtccgatctc gaattgcgga agcgccgccc
    22141 tgagctcgcg catgagcacg cgccattgat ccagtttctt gagctcttgt ttccacaagg
    22201 cctggaacct cttcagctcg gggctccttt ccagcttgcc atcaaactca tggtccgaac
    22261 gccagtattt ccgaacgaca gaaagcaact cttccgctga aattggcatg ggcttagaag
    22321 tcaactcgga tgggctttgt ttcctcttca caccaggctg tcactctcga gccaagcacg
    22381 gcgcgattca aaacgacatt gaaggtgctc gtgaattgcc tacagacgag gccaggaagt
    22441 ggggatgcgg gggaggcgat cacctctctc aatgcctcgt tggcacaatc ggcggcgatt
    22501 cgctgagcaa gcggctcgga catcagtcca aacttttcgg tcgcgatggg cattcccact
    22561 ccgaacttgc aaaaataagg ctccaaggtc gatttgttta ctacggttgc atggatacac
    22621 gcggcacgcc agccatctgc tcctgcttcg gttttttcga cgatggtagt gaattggaag
    22681 tggctgggtt ggtattgatt gatgctgcat cccgagacaa ctggcagcag cacccccggc
    22741 aaccgcagga gcgcggacat ccacgcgagt tgccttgaaa tgcccacggt atcaccttgg
    22801 atcaaaaggg tcagccaagc gcccggcaca tcatcccgac catcaccgag gaatcggcca
    22861 tccaaggcca tgccccggag ccctccacga agaggagact ccggggcggg gcgaggcctc
    22921 agctccagtc ggagtggatg aagccggcgt cgggccggtc gcggcgctgg taggtgtggg
    22981 cgcccaaggc gtcgcgctgg gcctgggtga ggttctgcgg cagctccggg ctgcggtagc
    23041 tgtcgaagta ggccaggctc gcgccgagca ccggcacggg gatgcccagc cgcgtggcca
    23101 ctcccacggt gcgccgccac gcgggcgcca tcttcccgag caccggtgcc agcctttcgg
    23161 ccaccatcac cttgagagag gacaggttgc acgcgtcgag cgctccggcg atggacggta
    23221 cgattctctg acgccttctc gaggcacctt ctcggagctg agactgcgga
//
