LOCUS       NZ_CP023257            21612 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain TLO3 chromosome, complete genome.
ACCESSION   NZ_CP023257
VERSION     NZ_CP023257.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4072939)
  AUTHORS   Zhang,X.
  TITLE     Oral bacillus subtilis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4072939)
  AUTHORS   Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2017) Key Laboratory of Oral Diseases of Gansu
            Province, Northwest University for Nationalities, No. 1
            Xibeixinchun, Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-APR-2017
            Assembly Method                   :: SOAPec v. MAY-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 136.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002290305.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:20:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,325
            CDSs (total)                      :: 4,204
            Genes (coding)                    :: 4,004
            CDSs (with protein)               :: 4,004
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 140 of 200
            Pseudo Genes (incomplete)         :: 65 of 200
            Pseudo Genes (internal stop)      :: 36 of 200
            Pseudo Genes (multiple problems)  :: 37 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:53:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3675995
            Orig. end                         :: 3697607
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023257.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="9"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11612](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11612
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     misc_feature    complement(115..129)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.21"
                     /tool="antismash"
     gene            complement(207..3893)
                     /gene="narG"
                     /locus_tag="CLD04_RS19435"
                     /old_locus_tag="CLD04_19435"
     CDS             complement(207..3893)
                     /GO_component="GO:0009325 - nitrate reductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008940 - nitrate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009061 - anaerobic respiration [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="narG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391609.2"
                     /locus_tag="CLD04_RS19435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19435"
                     /product="nitrate reductase subunit alpha"
                     /protein_id="WP_095844019.1"
                     /transl_table=11
                     /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTRDDRDWENVYRNRWQ
                     YDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGASFS
                     WYIYSPLRVKYPYVRGVLINLWREALQEHQNPLEAWKSIVENPEKAKSYKQARGKGGFV
                     RAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPMLSFY
                     DWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEARYKGAK
                     VISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEYAKQYTD
                     FPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGTMGSRWDG
                     QQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLPIKKMNLNG
                     EETYVTTVFDLILANYGVNRGIGEQQAVSYDDPEPFTPAWQEQMTGIKKEAVVKIAREF
                     AQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGWAHYVGQEKLR
                     PAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPIAASSRYKHHAD
                     YNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQLQEKKLKFAIEDP
                     DNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDSIRPEEIKWREQAP
                     EGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFIHPFAPAISAPWESK
                     SDWDIFKALSKAVSDLAEEVNMEPVKEVVATPLLHDTMQELAQPFGKINDWSKGECEAI
                     PGKTMPNIQVVERDYKHIFHKMTALGPNAALKPSGTKGMSWSIADEYESLKQRLGEITS
                     DSVAKGCPNISEAKQAAEAILALSSTSNGKVAVKAWESLENITNLKLKDLAEEREEECF
                     TFEQITAQPKTVITSPAFSGSEKGGRRYSPFTTNVEKLIPWRTLTGRQSYYVDHELMME
                     FGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKWSVHSMYFDSLPMLTLFRGG
                     PTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHRIPKGMAFMHHAQDRHINVPG
                     TKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYYGPTGNQRDLNVVIRKLKEVDW
                     LED"
     misc_feature    complement(3959..3974)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(3983..3996)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    3983..3997
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.64"
                     /tool="antismash"
     gene            complement(4084..4560)
                     /gene="arfM"
                     /locus_tag="CLD04_RS19440"
                     /old_locus_tag="CLD04_19440"
     CDS             complement(4084..4560)
                     /codon_start=1
                     /gene="arfM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391610.1"
                     /locus_tag="CLD04_RS19440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19440"
                     /product="Crp/Fnr family transcriptional regulator ArfM"
                     /protein_id="WP_003243032.1"
                     /transl_table=11
                     /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSFL
                     HSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSDIL
                     ILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS"
     misc_feature    complement(4618..4633)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            4704..5423
                     /gene="ywiC"
                     /locus_tag="CLD04_RS19445"
                     /old_locus_tag="CLD04_19445"
     CDS             4704..5423
                     /codon_start=1
                     /gene="ywiC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391611.1"
                     /locus_tag="CLD04_RS19445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19445"
                     /product="YwiC-like family protein"
                     /protein_id="WP_014481214.1"
                     /transl_table=11
                     /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLA
                     VYPVTLALKKKQSKPYQKWMCYYGFPACCFLMISVFHKPPLIWVGVSLLPLFLIHMYFA
                     RRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVI
                     RERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTIGILE
                     IVNACFFLAVMCLFITR"
     gene            complement(5455..6171)
                     /gene="fnr"
                     /locus_tag="CLD04_RS19450"
                     /old_locus_tag="CLD04_19450"
     CDS             complement(5455..6171)
                     /codon_start=1
                     /gene="fnr"
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391612.1"
                     /locus_tag="CLD04_RS19450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19450"
                     /product="fumarate/nitrate reduction transcriptional
                     regulator Fnr"
                     /protein_id="WP_003227573.1"
                     /transl_table=11
                     /translation="MNFLSVRPSDSDLISSDLHELLESISTKRKMEKHTYLFREGMDAE
                     ELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLV
                     INKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYG
                     VERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLR
                     CEIECENCPLEICNID"
     gene            complement(6270..7457)
                     /gene="narK"
                     /locus_tag="CLD04_RS19455"
                     /old_locus_tag="CLD04_19455"
     CDS             complement(6270..7457)
                     /codon_start=1
                     /gene="narK"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391613.2"
                     /locus_tag="CLD04_RS19455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19455"
                     /product="nitrate transporter NarK"
                     /protein_id="WP_010886631.1"
                     /transl_table=11
                     /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEIS
                     LVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGGFF
                     LGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKSTVQ
                     MYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAFVAFT
                     IYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFAGLTLS
                     GIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAMGGLGGF
                     FPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQSIN"
     misc_feature    complement(7522..7537)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            complement(7593..9263)
                     /gene="argS"
                     /locus_tag="CLD04_RS19460"
                     /old_locus_tag="CLD04_19460"
     CDS             complement(7593..9263)
                     /EC_number="6.1.1.19"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391614.1"
                     /locus_tag="CLD04_RS19460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19460"
                     /product="arginine--tRNA ligase"
                     /protein_id="WP_041334658.1"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLEFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     gene            complement(9260..9688)
                     /gene="ywiB"
                     /locus_tag="CLD04_RS19465"
                     /old_locus_tag="CLD04_19465"
     CDS             complement(9260..9688)
                     /codon_start=1
                     /gene="ywiB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391615.1"
                     /locus_tag="CLD04_RS19465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19465"
                     /product="DUF1934 domain-containing protein"
                     /protein_id="WP_003243604.1"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     misc_feature    9895..9910
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            10001..10132
                     /gene="sboA"
                     /locus_tag="CLD04_RS19470"
                     /old_locus_tag="CLD04_19470"
     CDS             10001..10132
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="sboA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391616.1"
                     /locus_tag="CLD04_RS19470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19470"
                     /product="subtilosin A"
                     /protein_id="WP_003222002.1"
                     /sec_met_domain="Subtilosin_A (E-value: 9.1e-29, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       10001..10030
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="CLD04_RS19470_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       10031..10132
                     /prepeptide="core"
                     /locus_tag="CLD04_RS19470_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[10000:10030](+)"
     gene            10089..10241
                     /gene="sboX"
                     /locus_tag="CLD04_RS19475"
                     /old_locus_tag="CLD04_19475"
     CDS             10089..10241
                     /codon_start=1
                     /gene="sboX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054594.1"
                     /locus_tag="CLD04_RS19475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19475"
                     /product="bacteriocin-like protein SboX"
                     /protein_id="WP_010886632.1"
                     /transl_table=11
                     /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIHT
                     QPFFI"
     gene            10266..11612
                     /gene="albA"
                     /locus_tag="CLD04_RS19480"
                     /old_locus_tag="CLD04_19480"
     CDS             10266..11612
                     /codon_start=1
                     /gene="albA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391617.1"
                     /locus_tag="CLD04_RS19480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19480"
                     /product="subtilosin maturase AlbA"
                     /protein_id="WP_041334655.1"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1081.0, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 5.1e-29,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-07, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.1e-44, bitscore:
                     150.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.5e-06, bitscore: 24.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-21, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.3e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-09, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIAHPTKDAEQHRKFMEYEQNVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     aSDomain        10281..10556
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CLD04_RS19480_Subtilosin_rSAM_RRE.1"
                     /evalue="3.40E-31"
                     /identifier="RREFam018.1"
                     /label="CLD04_RS19480"
                     /locus_tag="CLD04_RS19480"
                     /protein_end="97"
                     /protein_start="5"
                     /score="98.4"
                     /tool="antismash"
                     /translation="MFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLNKTAYE
                     LCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQ"
     gene            11625..11786
                     /gene="albB"
                     /locus_tag="CLD04_RS19485"
                     /old_locus_tag="CLD04_19485"
     CDS             11625..11786
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391618.1"
                     /locus_tag="CLD04_RS19485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19485"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbB"
                     /protein_id="WP_041334652.1"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGI
                     RARKADSR"
     gene            11783..12502
                     /gene="albC"
                     /locus_tag="CLD04_RS19490"
                     /old_locus_tag="CLD04_19490"
     CDS             11783..12502
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="albC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391619.1"
                     /locus_tag="CLD04_RS19490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19490"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_003227564.1"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     gene            12495..13805
                     /gene="albD"
                     /locus_tag="CLD04_RS19495"
                     /old_locus_tag="CLD04_19495"
     CDS             12495..13805
                     /codon_start=1
                     /gene="albD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391620.1"
                     /locus_tag="CLD04_RS19495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19495"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbD"
                     /protein_id="WP_095844020.1"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTMFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     WMFLLHAAIFACVCLSAALMPAATLPLCAVHMLWAVVIDFPVFLQAPPQQSRMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAAFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGLPIS
                     VLTFLQCIELLLAGAFIRLTADEKRPSFSWQTEQQLWSSFSKYRSYLFCLPLFLATLTG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     gene            13795..14955
                     /gene="albE"
                     /locus_tag="CLD04_RS19500"
                     /old_locus_tag="CLD04_19500"
     CDS             13795..14955
                     /codon_start=1
                     /gene="albE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391621.1"
                     /locus_tag="CLD04_RS19500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19500"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbE"
                     /protein_id="WP_095844150.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 3.5e-05,
                     bitscore: 21.8, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLK
                     EQIIDDFGCAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPS
                     SLSFEAVEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRKDRIKAIHP
                     KRFHDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSERIPVNRHVFETETRS
                     AAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYD
                     VMNNLLLVSICTDQLHEIDIPPRVLEAVSTFHTDERELEQAKQFLRNELLLQFDSPEGL
                     LAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     gene            14960..16240
                     /gene="albF"
                     /locus_tag="CLD04_RS19505"
                     /old_locus_tag="CLD04_19505"
     CDS             14960..16240
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="albF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391622.1"
                     /locus_tag="CLD04_RS19505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19505"
                     /product="pitrilysin family protein"
                     /protein_id="WP_095844021.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.5e-13, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKSFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAQRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYYAERKIIPACPPALSQKMMLGDEERMEDTWTGLQIGALPGQNDLLTIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     gene            16237..16938
                     /gene="albG"
                     /locus_tag="CLD04_RS19510"
                     /old_locus_tag="CLD04_19510"
     CDS             16237..16938
                     /codon_start=1
                     /gene="albG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391623.1"
                     /locus_tag="CLD04_RS19510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19510"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbG"
                     /protein_id="WP_095844022.1"
                     /transl_table=11
                     /translation="MKKNTVFTLLLLLIGMAAYSFGWVQAVAEAAAHYIQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILATIQQIGSFIYKR
                     FSYRSTASLDL"
     gene            complement(16944..18320)
                     /gene="ywhL"
                     /locus_tag="CLD04_RS19515"
                     /old_locus_tag="CLD04_19515"
     CDS             complement(16944..18320)
                     /codon_start=1
                     /gene="ywhL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391624.1"
                     /locus_tag="CLD04_RS19515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19515"
                     /product="YncE family protein"
                     /protein_id="WP_095844023.1"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDIPEGFKVDSAEAS
                     AAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGNGA
                     VSVIHTEEIDQVVYYAAQSDRCPDFSQMTVEDLLIVPPFYGSPLTVTGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDANTGQLVESIIDSFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVGAGPSAIAM
                     "
     misc_feature    18287..18304
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(18359..19714)
                     /gene="ywhK"
                     /locus_tag="CLD04_RS19520"
                     /old_locus_tag="CLD04_19520"
     CDS             complement(18359..19714)
                     /codon_start=1
                     /gene="ywhK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391625.1"
                     /locus_tag="CLD04_RS19520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19520"
                     /product="YncE family protein"
                     /protein_id="WP_095844024.1"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANSNDQSVSVIDTNTHSIVTTIALPYNPAGIEITPDKSAVFVSHPNNNV
                     ISVIDYDTLTVTASILLDQPPRLIRFIPNHEFAYVFTGTAVSVIGIDTLTVDRSIPVEG
                     YDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAYVLEQEF
                     FFNYLTVIDLNTFAISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPNGAGVIGN
                     VPQSARDFAFTPNGEFLYATHVLEQSITVYNTDDYSVETVISLGVSPGAITI"
     gene            complement(19711..19941)
                     /locus_tag="CLD04_RS22430"
                     /old_locus_tag="CLD04_19525"
     CDS             complement(19711..19941)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009968328.1"
                     /locus_tag="CLD04_RS22430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19525"
                     /product="hypothetical protein"
                     /protein_id="WP_024572000.1"
                     /transl_table=11
                     /translation="MQIPPFIILYMSYFIINILVRSAKKPQFFLSLHRMFGDIFSKRSF
                     YPQQFVQANTLPFHILLYLREQCMSEKEVKE"
     misc_feature    19895..19911
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            19944..21089
                     /locus_tag="CLD04_RS19530"
                     /old_locus_tag="CLD04_19530"
     CDS             19944..21089
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391626.1"
                     /locus_tag="CLD04_RS19530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19530"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_095844025.1"
                     /transl_table=11
                     /translation="MSGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDRREYVLAIQFFKKAESKLVFVKDKIDKAEFFFKMSEVYYYMKQTYVSMDY
                     ARQAFEIYSEQTTYDIRMIQCQSLFGANFLDLKQYEKAIAHFQKAFTLAKTEQQPQLMG
                     RTLYNIALCKQNQNSFESAIEYVKKSIQVFEGSKMLPSLPQAFFLITQIYFKLGKIDNA
                     CEYHKKGKEYSAAAGDTVYLTEFEFLESLYLSGPDEERIEKCFVFLESKMMYADIEDFA
                     LDVAKYYHQQENYKKASHYFLKVEEARQHIQGGVNLYEMEV"
     gene            21073..21192
                     /locus_tag="CLD04_RS19535"
                     /old_locus_tag="CLD04_19535"
     CDS             21073..21192
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003326489.1"
                     /locus_tag="CLD04_RS19535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_19535"
                     /product="PhrC/PhrF family phosphatase-inhibitory
                     pheromone"
                     /protein_id="WP_014665774.1"
                     /transl_table=11
                     /translation="MKWKYKLLLACLAVSAVFITVEVSNSSTEHFDVAQRAMI"
ORIGIN
        1 gctttccttt tttcaatgtc cagccgcctt tatatttgtc ctggtcctcc cattgcttcg
       61 ggtagccgat gcccggcttt gtttctacat tattgaagta catatattcc gcaccggaac
      121 ggtttgtcca cgtgtttttg caagtgacgc tgcacgtgtg gcagccgatg catttatcca
      181 agttcatgac cataccgatt tgcgctttaa tcttcaagcc aatcgacctc cttcagcttg
      241 cggatgacga cattcaggtc gcgctgattc cccgttgggc cgtaatagtt aaagccgtag
      301 ctgagctggg cgtagccccc gatcatctgt gtcggcttga cgtgaatcct tgtcgggctg
      361 ttatgggtgc ctccgcggtt atttgtcagt ttcgtgccgg gcacgttgat gtggcggtcc
      421 tgggcatggt gcataaacgc cattccttta ggaatccgat gagacaaaac ggctctcgcg
      481 acgactacgc catttcggtt aaagcattca atccaatcgt tgtctttgat atccgtgtcc
      541 tctgcatcat ctttattcat ccacacggtc ggcccaccgc ggaacagcgt cagcatcggc
      601 agagaatcaa aatacatgct gtggacagac catttattat gcggcgtcaa ataattgagg
      661 acgatttctt ttccctcttg atcaggccgc ttgctcagaa acgggcgatg ctggaggatc
      721 ggtttgaatg tcgccatcgt ttcaccgaat tccatcatca gttcatgatc gacataatag
      781 gattgtctgc ctgtcagcgt ccgccacggg attaattttt caacattcgt cgtaaacggc
      841 gaatacctgc gccctccttt ttcagagccg gaaaacgctg gagacgtgat caccgttttc
      901 ggctgggctg taatttgttc gaacgtaaag cattcttcct cgcgttcttc cgccaggtct
      961 ttcagcttca ggttcgtgat gttttcaagt gattcccatg ctttgacggc gacctttcca
     1021 ttcgaagtgg atgatagggc taaaatcgct tctgccgcct gctttgcttc acttatattt
     1081 ggacatccct ttgcgacgct gtccgaggtg atttctccca atctctgttt gagtgattca
     1141 tattcatcgg ctattgacca gctcatccct tttgttccgc tcggctttaa agcagcgtta
     1201 ggaccgagtg cggtcatttt atgaaaaatg tgtttgtaat cccgttcaac gacttggatg
     1261 ttcggcatcg tttttcccgg aatggcttca cattcgccct tgctccagtc attgattttg
     1321 ccgaatggct gggccaattc ctgcatggtg tcgtggagga gcggcgtcgc aaccacttct
     1381 ttcaccggct ccatattgac ttcttctgcc agatcggaaa cggcttttga cagcgccttg
     1441 aaaatatccc agtctgactt cgattcccac ggagctgaga tcgccggagc aaatggatga
     1501 atgaacggat gcatatctgt gctgctgaga tcgtgttttt cataccatgt cgccgccggc
     1561 agcacgatat cggaatacag cgccgtaccc gccattcgaa aatcaagatt gattaataag
     1621 tcgagctttc cttccggcgc ctgctcccgc catttgattt cttcaggacg gatgctgtcg
     1681 ctgtcgtcat tcatcaagcc gttcgtcgtc cctaacaaat gcttgagaaa atattcatgc
     1741 ccttttcctg agcttgagat cagatttgcc cgccatacaa agagattcct tgggaaattc
     1801 acttcattgt caggatcttc aatcgcgaat ttcagttttt tctcttggag ctgtgaggcc
     1861 acgtacgcac ctacgtcttc aggtgttgct gcccctgctt tttcagcttc tttatacaga
     1921 tcgatgccat tttgattgaa agtcgggtaa gacggaagcc accctagccg cgccgccagc
     1981 acattgtaat cagcgtggtg cttgtagcgg gatgacgcag caatcggtga tgccaaatca
     2041 ctgatcggct ggtcctcata acgccactga tctgtcgcaa agtagaaaaa tgaagtgccg
     2101 ttttgcagct tgggcacgcc ctcccagtcc tttgcagttg caatcgtctg ccatccttca
     2161 gcaggtcgga gcttttcctg cccgacgtaa tgggcccagc ctccgccatt tacgccttgg
     2221 gcgcctacaa gcaaaacaag atttaacact gctcggtaga tcgtgtcgga gttgaaccag
     2281 tggttaatgc cggctcctac gataatcata gaccggccgt ctgtatcgat cgcattttga
     2341 gcaaactctc tggcaatctt aacgacagct tcttttttga ttcctgtcat ttgttcctgc
     2401 caggcaggcg taaacggctc aggatcatca taggagacag cttgttgttc gccgatgccc
     2461 cgatttacgc cgtagttagc cagtatcaag tcaaacacgg tcgtgacgta cgtctcttca
     2521 ccgttcaggt tcattttttt aataggaaga tcccgctcga gcactttgtt tccgtcattt
     2581 gaaaaataag gaatgcgcac cgtgccgatt tcatcctcta ttccgagcac agagagacgg
     2641 ggttcaatcg gttccccggt ttcttcatca atcatgtgca ggttccattt ctgctgcccg
     2701 tcccagcgcg agcccattgt cccttggggt atggcaaatg aacttgtctg ttcatcccaa
     2761 accgcaggct tccactgatc atgctttgtc ttccgcccga tgtccttcgc atgcagaaac
     2821 cgtcccgctg tgtatacgcc attttctttt gacagggtga cgagaaatgg aaaatcagtg
     2881 tattgcttcg cgtactcaat aaaacgttca gtttcttggt tcacgtaaaa ttcctgcaga
     2941 atgacgtgac ccatcgccat cgcaagcgcc ccgtcagtcc cttggcgaat actcagccag
     3001 tcatccgcga actttgagga ttccgcaaaa tccggactga tcgaaatgac cttagcgcct
     3061 ttatagcggg cctccgccaa aaaatgcgcg tcaggcgttc tcgttaacgg aacgttggag
     3121 ccccatgtga tgatatagcc ggaattgtac caatcactgc tttccggaac gtccgtctgg
     3181 tcaccccaaa tttgcgggga tgccggagga agatccgcat accagtcata aaaactgagc
     3241 atagggcctc cgattaacga cataaaccgg gagcctgatg catggctgat catggacatg
     3301 gccggaatcg gagaaaaacc gacgtttctg tcaggcccgt atttcatcac tgtatacagc
     3361 agagaggctg aaatcagctt cagcacctcc ggccattcag cgcgcacaaa accgcctttc
     3421 cctctcgcct gtttatagga cttcgctttt tcagggtttt cgacgatcga tttccaggct
     3481 tccaatggat tttgatgttc ttgcagtgcc tcccgccata aattaatcag tacaccgcgc
     3541 acgtatggat atttcacacg cagcgggctg tagatatacc atgaaaaact ggccccccgc
     3601 gggcagcctc tcggttcaaa atcaggcata tccgggcctg ttgatggata attcaaattt
     3661 tgcccttccc acgtgacaat tccgtttttc acataaatat tccagctgca agaccctgta
     3721 cagttaacgc cgtgggtgga gcgaacgact ttgtcgtact gccatctgtt tctgtataca
     3781 ttctcccaat cgcgatcgtc gcgggtggtt tggctatgtt tatttgaatg gtgttcgata
     3841 ggagagaaat aattcaatct cctaaacaac ggactccttt tctttttctt catgagagtt
     3901 cactccttcc gagtcaggtg atgctaagtt cactataaac agagacagcg tgtttccttg
     3961 tgaactatgt cacacactcc gcttttttca caaaatgttc acacaaagga gaaggaaggc
     4021 tgcgttcagg cagaacgctt gggtcattag ccgcctttca aagatcaaaa aaaccggctc
     4081 tatttaagaa ccgggctcgg cgttttcatc ctgtgatgta tgcagatacc gcaaaaataa
     4141 ttgataggaa caaaaaacat tttgctgaag catagccaaa aagttcattt gcagctgcgg
     4201 atgataagac atcattttct taaatatgta atatgggatg ttgagaatca gaatgtctga
     4261 agtggcattg actgagataa agggcgataa ataaagcccg cctttttcat caatcggaaa
     4321 cacatcgcct ttttcccaca gcgcaacggt tttcgaccct tcagggagcc ttgtgtccat
     4381 aaaacggaca ctgcctttta atacaatata aacagattga gaatgaagaa aagatggaga
     4441 ctgatcacac gaaccgcgga taaacgtgcc gtttttcagc aaggtttcga caatggatag
     4501 aggcacttca ttaaacatag gaagttgttt cagaaataat aaatagtcac actgattcat
     4561 aggaaaacct cctgtgctaa ggatagcttt agtgtagctc gactgagcct gtacagcagt
     4621 gatgtatttc acagcctgta tgatgaatgt cacttatcag gagggtgaat gcatttataa
     4681 tgaaagaaaa aaggaggatt tcgatgaagg cgctgattcc gaagcagcac ggggcgtggg
     4741 cgatgctgct gatcccattt ttactcggca tggtcaaggg aggccccgtt atttggcata
     4801 ttccgctctt ccttggttgg cttttcctat acttagcggt ttatcccgtt acgcttgcct
     4861 taaaaaagaa acaaagcaaa ccatatcaaa agtggatgtg ttattacggt tttcccgcct
     4921 gctgcttttt gatgatctcg gtctttcata agccgcctct catctgggtg ggcgtttctt
     4981 tactgccgct gtttctcata catatgtatt ttgcccgcag aaaaaacgaa cgagccttat
     5041 tgaatgatgt tgcaggtgtc ttgttctttt gttcgggcgg gtttgcgagc tgctggctgg
     5101 ggatgggaac ccttgacggc tgggcttggt ttattttctt gcagtctgct ttatttttta
     5161 tcgggagttc cttttatgtg aaatcggtga tccgcgagag aaaaaacagg gcatttgcat
     5221 actggtcatg gggatatcac ctgctgctcc cctttttatc cgctcttttc ggagcaggat
     5281 gggcgtttct cgcttttatc ccgagcagct tgcgggcatg gttttttcat ggaagggatt
     5341 ggcccgtaaa aacgattggc attcttgaaa tcgtgaatgc ctgcttcttt cttgccgtca
     5401 tgtgcctgtt tatcacaagg taaaaaaaca aggacaccgc tgtccttgtt tttttcagtc
     5461 aatattgcaa atctccagcg ggcaattttc acactcaatc tcacatcgta aatagtcccg
     5521 cttgtgcaaa ataattttcc cggattcgtc tatcgaaata accccttttt tgcggagatc
     5581 tccgagcata cgattgacgc tttcccgtgc agccgcgcaa aactttgcca aatcctgatt
     5641 tgtcaggaca atgttaatca gaatgccgtc gcttcgctcc actccgtagc tgtttgataa
     5701 acggataagg gtggaataga gcgccccctt tttgccatga agaagcagat ccctgatttt
     5761 ggactgaatc ttccggaggt gcgtgctcat ccatttcatg aactcaaatg tcaaagcgcc
     5821 gttttggatt aattcttttt ccagcttatt tttattaatg acgagcacct cgccatcctc
     5881 tagcactttt gcactgagca tataccttgg ttcttcagtg aaaagtgtta attctccgac
     5941 gatatcatgc ttttggcaga ttctaagcgt caggtctttt ccgtcagatg tcagcttgcc
     6001 gatttcaatg agtcctgatt gaatcagata aagctcttct gcatccattc cttctcgaaa
     6061 caaatacgtg tgtttttcca tttttctttt cgtgctgatc gattccagca attcatgcag
     6121 atcgctggat ataagatcac tatcagatgg tcgaacagag agaaaattca tgagctcacc
     6181 tcgaagaaag tcacgttgtg tgtttattgt aacgtgaatt gatttgtacc catcgagaaa
     6241 aaactaacaa tcttgtgaat gccccagtgt tagttgatgc tctggctgtt tctctccgtg
     6301 tgtgttttca ttctttcctg ccaatacatc catatgacaa ggacaaagct ggctaacgcc
     6361 acctctgaaa gcgccataaa cccgatcgcg tactggcctg ttgcctgaaa cacactcgcc
     6421 aatatgagcg gaggaaaaaa gccgcctaat ccgcccatgg cagacacaat cccattggca
     6481 atccccgctt gcttcgaaaa atagaaaggc accagtttaa aaacagtccc gtttcctatg
     6541 cctgagcaga cggccacggt taatgatcca aacgtataaa ggccgattgt cggcgagaac
     6601 gataggataa tgcctgataa tgtaagcccg gcaaaaacaa acatcaagat gcggagcggg
     6661 ctcattttat cagccaggaa tccgcccgca ggcctgagca gcgtagaaac cgcaataaag
     6721 ccagccgtcc gcaagccggc atctgcagga ttcagcccaa aatgctccac cagaaagttc
     6781 ggcagataga tagtgaaggc gacaaaggca ccgaacgtaa taaaataaaa caggctcaga
     6841 aaccatagca catgatttcg gtaaacggct ttgatttgag tcttaacaga aactttgacc
     6901 ttcttctcat gcctgtcgcc aaacaatacg tgcagtaagg caaagacagc cagcaaaatc
     6961 agatacatct gcacggttga tttccaaccg acggcttgag cgataaccgg cgctgcaaat
     7021 gtcgtaacgg ctgtcccgat atttcctgca ccgtaaatcc cattgacgac accgtgcttt
     7081 tctttcggat aatatttcgg gagggaggtc actccaatgg aaaacaccgc tcccccgatc
     7141 cctaagaaaa agccgcctgc gattaaatca aacagagaat ccgcgatact gatccaaaat
     7201 acaggaaata aaagcaggat gaagctgacc ataaacatga gccgcgcgcc aaacctgttc
     7261 gttaaatacc ctaaaggaat gcggagaagc gacccgagga tcacaggaat tgccgtcacc
     7321 aaagaaatct cacccttgct taaatgaata tctaatgtga tttgggaaat gagtgatgaa
     7381 atcagcaccc aaaccataaa ccctgccacc aagcttaatg actgtaacga taattgaatg
     7441 tgttgacggt tgatcatttg gcttgcccct ttcaatgatt caataatcag tcttatcata
     7501 caaaaactcg gcaaacagga ttgtgaatta catcacacgt ttttctcata aaaaaaggac
     7561 aaagcccgaa gactttgtcc ttttgatcgt gattacattt tttccggagc cgatacgccg
     7621 atcagctgaa gcgcattgtt cagcgtaatt tgcgttgcct tcattaaagc caggcgcgcg
     7681 cggcttttct cttcattttc agggtcgatg actttctctg cgttgtagaa gctgtgcaga
     7741 gcagaagcca gatcataaat atagtttgtg acacggtgcg gaattcgttt ttccgctgct
     7801 tccgccactg cctctgggaa gccgccgatc gttttcagca gatcgtattc tttttctgat
     7861 tgaatatggc tgaaatcaag atctgccgcc ggtttaagtc cctgctcttc cccttggcga
     7921 agcatgctgc aaatacgggc atgcgcgtat tgtgcataat acacagggtt ttcgttagat
     7981 gttgatacag caagatctaa gtcaaaatcc atatgggtgt ccgcacttcg catcgcaaag
     8041 aagtaacgaa cggcatccaa gccgacttct tcaatcaggt cacgcatcgt tacggcttta
     8101 ccggtccgtt tgctcatttt cattttctcg ccgtttttgt aaagatgaac gagctgaatg
     8161 atttctactt caagcgttcc tttttcatag cccagcgctt caattgccgc tttcatacgc
     8221 gggatgtagc cgtggtgatc ggcgccccaa acgttgatca gcttatcaaa gccgcggtca
     8281 agcttgtcct tatgatacgc gatatcagga agaaggtacg tgtacgtgcc gtccttcttg
     8341 atcaatacgc ggtctttatc atcgccgaaa gtcgtggaac ggaaccaagt cgcgccgtct
     8401 tcttcataga catggccttt ttcgcggagc gcttcaagcg ccttgtcaat ttttccattt
     8461 tggtacagtg aagtttctga ataccacaca tcaaacggca cacggaagtt ttccaagtcc
     8521 ttgcgcagct tttccagctc gtatttcagg ccgtattcac ggaaaaactc gaggcgttca
     8581 ctttcctctt cgttaacgaa acgatcaccg tattcctcag cgagacgctt tccgatcgca
     8641 atgatatcct cgccgcggta gccatcctcc ggcatcggtt tttccaatcc gagtgcttca
     8701 aagtaacgga cttcaacaga aagcgccaga ttgttgattt ggtttcccgc atcgttaatg
     8761 tagtattcgc ggcttacatc gtaacccgct tttgaaagca cgttgcacaa ggaatcgccg
     8821 acagccgccc cgcgcgcatg cccgaggtga aggtctcccg tcggattcgc tgatacgaat
     8881 tctacctgaa ctcgttcacc gtttccgatg tttgtttccc cgtatgcttc ccccgcttcc
     8941 agtacagacg gaatcagctt tgttaaatat tgattgttca tatagaaatt gataaaaccc
     9001 gggccggcga tatccagttt ttcaatcgaa gcctttcctt tatcaaaatg agcgacaatc
     9061 tcttcagcga tttgacgcgg cgcttttttt gccactcttg ccaactgcat cgccatattc
     9121 gttgagtagt cgccgtgtgt tttatctttc ggtgtttcta aaacaacatt gggaatctgg
     9181 ctttcttcag ccagtcccgc tttcagaacg gccgctttga tttcttcttt cagcacgtcc
     9241 ttcatttgtt ccgcaatgtt catgcgtgag ttcctccctc atacgtgatc gtcatattat
     9301 gtaaatgctc ctgctcgtct ccgacatgca tgtcatatgc gatgctgata cggccttttt
     9361 cttcatcgag atcagattga atcgattttg tgcttgtttt cagctcaagc tcaccaaatg
     9421 acattttata tttagcaatt gtggaagctc ccgttacgaa acgctgattc attttgacag
     9481 cgcctgacct catgaccagg acttcgcctt cgcttacttt cacaatcgtt ttgactttgc
     9541 ctaagtcgtg ttcttcataa taagatagat acactttatt ttgttttaca tagtaaaatc
     9601 cggtggtgcg gaattcgatg acttcttggt ttccgtcatc ctcgatcaca gacttcacat
     9661 ggagtgttat cggtgtctct tgcttcattc tgacacgtcc ttttcatcat tccactttga
     9721 cttgaatagt ataatcattc ggtttgtaaa cttcaactgc ttctatctta ccatcattgc
     9781 tcatcagatt tgaagataaa cctcataaaa agcatttcct tatatagaag agaaaatcat
     9841 atcactaatt acctttagga aatgttacat ttttccgaaa tctatcattt ccttttcaca
     9901 tttttttcaa aatatatgca ttgaattagt aatttgatag ttttaagata aaagtacaac
     9961 atagatctgc tagaaaaaca aaaaaaggga ggattcaatt atgaaaaaag ctgtcattgt
    10021 agaaaacaaa ggttgtgcaa catgctcgat cggagccgct tgtctagtgg acggtcctat
    10081 ccctgatttt gaaattgccg gtgcaacagg tctattcggt ctatgggggt aaggatctcc
    10141 caaaagggca tagtcattct actatgccct ttttaagtaa attacaattt ttaactaaaa
    10201 tctacctctt ggatatacat acacaaccgt ttttcatttg aatcatatgt ataggggatg
    10261 gtattttgtt tatagagcag atgtttccat ttattaatga aagtgtaaga gttcaccagc
    10321 ttcctgaggg cggcgtgtta gaaatcgact acttgcgcga taatgtctcc atttctgact
    10381 ttgagtattt ggatctcaac aaaacggctt acgagctctg catgcgcatg gatggccaaa
    10441 aaacagctga gcagatttta gctgagcaat gtgcagtgta tgatgaatca ccggaagacc
    10501 ataaagattg gtattacgac atgcttaaca tgctccagaa caagcaggtg atccagcttg
    10561 gaaaccgggc cagccgccat acaatcacca cgagcggcag caatgaattt ccgatgcccc
    10621 tgcacgccac ctttgaactg acgcaccgct gtaatttgaa atgcgcccac tgttatttgg
    10681 aaagctcacc tgaagcgctc ggcaccgtgt cgattgagca attcaaaaaa acggctgata
    10741 tgctgtttga taacggtgta ttgacatgcg aaatcacagg cggagaaatt tttgtccatc
    10801 caaacgccaa tgagattctt gactatgtgt gtaaaaagtt caaaaaagtc gctgtcttaa
    10861 caaacggaac actcatgcga aaagagagcc tggagctttt gaagacttac aagcaaaaaa
    10921 tcatcgtcgg catttctctt gatagtgtca attccgaggt ccatgactcc tttagaggga
    10981 gaaaaggctc ttttgcccaa acttgtaaaa cgataaaatt gttgagtgac cacggtatat
    11041 ttgtcagagt cgccatgtct gtcttcgaaa aaaacatgtg ggaaatccac gatatggccc
    11101 aaaaggttcg ggatctcggg gcgaaggcat tttcttacaa ttgggttgac gatttcggaa
    11161 gaggcaggga tattgcccat ccaacgaaag acgccgagca gcaccgcaag tttatggaat
    11221 acgagcaaaa tgtgattgat gagtttaaag atctgattcc gattattccc tatgagagaa
    11281 aacgcgcggc aaattgcggc gctggctgga agtccattgt gatcagcccg ttcggcgaag
    11341 tacgtccttg cgccctcttt ccaaaggaat tttcattggg aaatattttt catgattcct
    11401 atgaaagcat ctttaactcc cctctcgtcc ataaactgtg gcaagcgcag gcgccgcggt
    11461 tcagtgaaca ttgcatgaaa gacaaatgcc cgttcagcgg ctattgcgga ggctgttact
    11521 taaaagggct gaactctaac aaatatcacc gaaaaaacat ttgctcttgg gcgaaaaatg
    11581 aacaattaga agacgtggtc cagcttattt aggagggaaa cgatttgtca ccagcacaaa
    11641 gaagaatttt actgtatatc ctttcattta tctttgtcat cggcgcagtc gtctattttg
    11701 tcaaaagcga ctatctgttt acgctgattt tcattgccat tgccattctg ttcgggattc
    11761 gcgcgcggaa ggctgactcg cgatgagcat tttggatata cacgatgtat ccgtttggta
    11821 tgaacgggac aacgtcatct tagaacaagt ggatttacat ttagaaaaag gcgccgttta
    11881 cgggttgctt ggggtaaacg gcgccggaaa aacgacactg attaatacgc tgacaggcgt
    11941 gaaccgcaat ttcagcgggc gctttacact gtgcggaatt gaagcggagg ccggcatgcc
    12001 gcagaaaaca tcagatcagc tgaagactca ccgttacttc gccgccgatt atccgctgct
    12061 atttacagaa attacggcga aggactatgt gtctttcgtc cattcgcttt atcaaaagga
    12121 tttttcagag cagcagtttg ccagtttggc cgaggccttt catttttcga aatacatcaa
    12181 caggagaatt tcggagcttt ccttggggaa caggcaaaag gttgtattga tgacaggctt
    12241 attgctgcgc gctcccctgt ttattttgga tgagccgctc gtcggtttgg atgtggaatc
    12301 gatagaggtt ttttatcaga aaatgcgcga gtactgtgaa gcaggcggga ccattttgtt
    12361 ttcttctcat ctgctcgatg tcgtgcaaag attttgtgat tatgcggcta ttcttcacaa
    12421 caaacagatc caaaaggtca ttccgattgg agaggagacc gatctgcggc gggaattttt
    12481 cgaggtgatc ggtcatgaat aacataatcc ccattatgtc tttgctgttc aaacagcttt
    12541 acagccggca agggaaaaag gacgccatcc gcattgccgc aggcctagtc attctggccg
    12601 tatttgaaat cgggctgatc cgccaggccg gcattgatga atcggtgttg cgcaaaacgt
    12661 atatcatact cgcgcttctc ttaatgaacg catatatggt gtttctttct gtgacatctc
    12721 aatggaagga atcttatatg aaactgagct gcctgctgcc gatttcttca cggagctttt
    12781 ggctcgccca gagtgtcgtt ttgtttgtcg atacctgttt gagaagaacg ttattctttt
    12841 ttattttacc gctgttctta tttggaaacg gaacgctgtc aggggcgcaa acaatgtttt
    12901 ggctcggcag gttttcgttt tttaccgttt actccattat tttcggagtt gtgctaagca
    12961 accacttcgt caaaaagaag aactggatgt ttctgctgca tgcggcgata ttcgcctgtg
    13021 tatgtctcag cgccgctttg atgccggccg ccacgcttcc gctttgcgca gttcatatgc
    13081 tgtgggcggt ggtcattgac tttcctgtct ttctgcaggc gcctccgcag cagagcagga
    13141 tgcattcatt tatgcggcga tctgagtttt cgttttacaa aagagaatgg aaccgattta
    13201 tctcttctaa agcgatgctg ttaaattacg cggtaatggc ggcgttcagc ggcttctttt
    13261 cgttccagat gatgaatacc ggcatcttca atcagcaagt gatttatatc gtgatttccg
    13321 cgcttttgct catctgctcg ccgatcgccc ttttgtactc gattgaaaaa aatgaccgga
    13381 tgctgctcat cacgcttccg atcaagcgga aaacgatgtt ttgggcgaaa tatcgctttt
    13441 attcaggcct attggcaggc ggatttctcc ttgtcgtgat gattgtgggt ttcatcagcg
    13501 gccttccgat ttcagttctc acttttttgc agtgcattga gttgctgctg gcgggagctt
    13561 ttatcaggtt aactgcggat gaaaaaaggc cctccttcag ctggcagacg gagcagcagc
    13621 tatggagcag tttctcaaaa tatcggtctt atctgttttg tcttccccta ttcttagcca
    13681 cattaaccgg caccgctgta tccttggcgg tcattccgat agccggtctg gtcatagtct
    13741 attacctgca aaaacaggat ggtggtttct ttgatacaag caaaagagaa cggcttggaa
    13801 gttaacctgc tgaagactca tcaattttca actatatcaa tcgccgcgag ctttctgaaa
    13861 ccgatcgaaa gcgcggcgga acctgaggaa gaaacgattt atttttacgg cgccgccgca
    13921 tacctgaagg agcaaatcat tgacgatttc ggttgtgctg ccggcagccg tttcatgtac
    13981 tcagcgaatc tcttttttga tcagcagctg aaaacctgcg ggacccgttt gattcaccca
    14041 ttatataacg ggaatcttca tgttgacgcc ctgatgaaaa cttttgcaga cttgtctttc
    14101 ccttcttctc tttcattcga agcagttgaa aaggccagga atgagctgct gctgaaaatc
    14161 gaaaagaaat tcactgatcc cttctcctac tcggcggcgc gcttggctga ggaggtcttc
    14221 ggaaacccga tgtacggcac aggcatgttt ggccggaaag acaggataaa ggcgattcat
    14281 cctaaacggt ttcacgacgc aacggacttt atcgttgatt tagtgtccca gcaaaaacag
    14341 ctgaacatat tgggacaagt acaagcatgt gatgttcggg gacatgcccc gcaaacgtcc
    14401 gctgtaacgt ccgaaagaat acccgtaaac cggcatgttt ttgaaacaga gacacgcagc
    14461 gctgcaggtc cttccgtctt gacactcgga tttgactgcg gagagatgaa agatgccagt
    14521 gattatatca aaatacagct aatagacgga ttactgggaa agtacggcca ttccgcttta
    14581 ttcaagcact tcagagagaa ggatctggca gtctatcacg ttatcacccg ttacgatgtc
    14641 atgaacaatt tgctgcttgt ttcaatatgt acagatcagc ttcatgagat agacattccc
    14701 ccgcgcgttt tggaagctgt ctcaactttt catacagatg agcgggaact agaacaggca
    14761 aagcagtttt tacgcaatga attgctgctg caattcgatt ctcccgaagg tctattggcc
    14821 tatatgggga tcctgcgccg cttctcctgc acgaaagaag ccttgctgga tggcatctca
    14881 gcggttacat gccgtgatgt attgcaattc atagcgacca tcaattatat cggagctcat
    14941 gtagtaaggg gatgaaaaga tggaaaagaa atcctttttt caacaactgg atgaacgaac
    15001 cgatatcaga tacacagaca gcggactaaa aatattcaga ttgaaattcc cccgcgccca
    15061 cctgcggctg tgcaatgtaa aaatcgattt tggaagccgg gatgtatgta tacgggcaga
    15121 atccggtgat acactgcttc cgtatggcac agcgcatttt ttagagcatc ttctcttctg
    15181 gcataacggc cgcaatctgt acagtgattt ttttgcgcat ggcgcgcttt taaacgcatt
    15241 cactacctac accgatacca atttcatgtt tacctcatta ccggatcggc tcagacaaac
    15301 gatccccatc ctgcttgatg ctttatggaa ccactcattt gacaagaaga ttgtcgctca
    15361 ggaaaaagct gtgattacaa gcgaaattca aacagcacac cttaaccatc agctctcata
    15421 tcattatcag ctgatcagca tgctttctcc ctcctcacca gctgccgttt tccccgcagg
    15481 cagaatcgaa gatattgagg cgcttgacat cagtgattta caaaaagcct ataaggctgc
    15541 ctaccaagcc caacggatga cgctgttttt gattgggggc tcagaaaata cagaaacgct
    15601 tttgcctcct cacctccagc tggaaaagcg tccggattat tatgctgaaa gaaaaatcat
    15661 tccggcatgc cctccagccc tctcacaaaa aatgatgctg ggtgatgagg agcggatgga
    15721 agatacatgg accggattac agatcggcgc acttcccggg caaaacgatc tgttgacgat
    15781 caagctttat tgggatatcg cggctcgtat actatttcaa ttagattcac cgttttttca
    15841 agagattcag caaacgtacc gcctggaaat cgatcgcttg tcagccgaga cttatatcta
    15901 tgaggatggc ggtttcttga tccttcacag tcaagggacc cattcttcag cttatatcga
    15961 tgtggcttca tactatgtca cacagaagaa agaacaggtt gccgcctggc ttcaatacgg
    16021 caaggactct ttgacagacg cgatcattta tgacagcgat tatgtgcgta aatgcttcga
    16081 gtgggcagcc gagtgtgaca ggtgcgattg ctcgtttctt gacatgtacc acatcattca
    16141 agatatggat gcgcaggttt tcttgtctct cattgatgca atggcatctt ctaacaaagc
    16201 gatcattcac gtttcccaga aagaggcgat cagacaatga aaaaaaacac tgtctttacc
    16261 cttttattgc tgcttatagg tatggcggct tattccttcg gctgggttca ggccgttgcc
    16321 gaagccgccg cccactatat acagatgatc aacaatgatg ctgtacggct cggactgctg
    16381 gcttgtaccg ctgccctcct gatgctgcct gcttttctct atcttcatta tgtcacccaa
    16441 tccgtgaaaa acatgacagc agcttttcag aaactcacac agtctcatca aagctgctgt
    16501 gactttcagc aacacaactt gtgcagccga tatgcagaag acgtcaaatc gctgcgtgac
    16561 agctataaaa acgtccgcca aacatacgtg atggctgccg tgttgtgcca agtcatcata
    16621 ttcggctgca tgttcgaaat cgttaaagcc gtccctttcc gccttcacac gccccctgcc
    16681 ctttcaatgg gacttgcgat gctactgatt ctgtatttat tgttttgcat gcgaacttat
    16741 ttgcggcagc ttttccggca cggcagcctg ttcagaaaag tgtttgcggg agcgctggca
    16801 gcagccggga tttggtggat gctcagtttc tctataagtg aactgctgtt tctgattatc
    16861 ctggctacca ttcagcaaat cggatcattt atttataaac gattctctta tcgcagcacc
    16921 gcttctcttg atctataaaa tagctacatc gcaatcgcag acggacccgc gccaaccgga
    16981 atcaccgtca cggctgtata atcacttgtg cggtacacgg ttacagcatt gtcgttgggc
    17041 tgtgccgcat aaatatactg tttgtccggc gttacggcga ggtcaaaagc gccggggaga
    17101 gacacgtttg caatgatcct ctgtctggcc gtattaacta catataagtt attaataaga
    17161 aacggttcac tatatggctc tagaaaataa gctctagtgc tatcgagaga aaatacaatc
    17221 gtcctcagcg tttcaaataa acggctgaag tcccctcccc tgcttaatgg agacaaacta
    17281 atctccgtta cacctttcgg ccacagctca ccattcaaca cgtacgcaaa atttccagcg
    17341 taaggagttg caattaaact gggaaattca aatgaatcta tgatactttc taccaactgc
    17401 ccagtatttg catcatattt atcaaccgac caactgcttc cattagcggt atagacatac
    17461 tgtccattcg gatcaagagc aaagtctaaa gcgccgggta tcggaatgac atcaatgacc
    17521 gattgagagg ccgtgttaat cacatatata gatccggcgg ccatcacgta tgcgaactca
    17581 tctgttggat caaattcgat ctttctcggc cctcctccaa cagtaatggt atttatgatg
    17641 gttaatgttt tattatcaat cactgagaca aggttggtat ttccatggag gacatacgtg
    17701 aatgctttat cgaaagtaac gcctagatta gttggcacgt cagaaaaagg gattgttttt
    17761 acaacagtgt ttaaatctgc atcaataacc gaaaccgtgc tgtctccagt attggcagta
    17821 aacacatacg attgagggtc tggtgatggc ggtaaaacaa gtgtcccggt caccgtaagc
    17881 ggactgccgt agaaaggcgg tacaatgagc agatcttcca ctgtcatttg actaaaatca
    17941 ggacagcggt cagactgtgc tgcataataa acaacttgat caatctcttc agtatgaatc
    18001 acagaaaccg ccccattgcc ttgtccatat tgatttcgca caggcgacac actgacaaga
    18061 agcgtaatgg tcccttgtac tctcacagca tatcgaacac cgatatcttc tggttccggc
    18121 ccagtctgga ttaagcaagg ctcactgata caggacaaat tgtctgtact ccatgtaaca
    18181 gccgctgacg cttctgccga atcaaccttg aagccctcag ggatatctat cggcacttga
    18241 aacggcgctt cccggctaat ttcctcatca caaaaacaga aacaattttc ctgtaaagca
    18301 gaaagatcat tctttttcat gatttcacgt ccttttagaa atgcacaaca tgcagcggtt
    18361 aaatcgtaat ggcacccggt gaaaccccaa gagatatcac agtctccacg gagtaatcat
    18421 ccgtgttgta aacagtgatg ctctgttcta gaacatgagt tgcatacaga aattcgccat
    18481 tcggggtaaa cgcaaagtct cttgccgact gcggaacatt tcctataacg cctgctccat
    18541 ttggactgac agaatataaa ttgccagtga agccgtcata taaatacacc tctgctccac
    18601 tcgtaaacat tcgatattcc ccttcatact ccagctcttg ggtgctgctg atggcaaacg
    18661 tatttaaatc aataaccgtc aaataattaa aaaagaattc ttgttctaat acataggcat
    18721 accgctccgg ccaatttgtt tctatggttg atacgataag ctctcgttca attgttcctg
    18781 tgacttcacc ggtagttagg tccacttttt gcactatacc aaaatttaga acataggcga
    18841 ataacccatt gggatcgatt gcaacatcat acccttccac aggaatcgac ctatccacag
    18901 ttaacgtatc aattccaatc acagaaaccg cagtaccggt gaaaacataa gcaaactcat
    18961 gattagggat aaatctaatc aatcgaggcg gctgatccag caatatagat gctgtcactg
    19021 ttaatgtgtc ataatcgatg acagaaatca cattattgtt gggatgtgag acaaacacag
    19081 cgcttttatc cggggtaatt tcaatacctg ccggattgta cggaagagca atcgttgtca
    19141 caatagaatg agtgtttgta tcaatcacag aaactgattg atcatttgaa ttcgctgtaa
    19201 acgcataaac gggttccggc tccggtacaa gcacaatcgt ccccgtcacc gataaaggac
    19261 tgccgtaaaa cggcggaaca acaacaaggt tctcaatcgt gatgtcactg atatccgggc
    19321 aatcatccgg ttcatcggaa taatagacga cttgatcgat ctctgcattg tgaatgacgg
    19381 aaacagcccc gtccccttgt ccatattgat ttcgcacagg tgagacactg acgagtagcg
    19441 taacggttcc ctgcaggcgc actgcaaatt gaacaccgac ctcatcaggc tcaggccccg
    19501 tttgaattaa gcaacggtca ctgacacaag aaaggctgtc tgcattccac gtcacgtttg
    19561 caacagcttc agccggatca acgacaaacc cttcaggtaa ttcaatcggt gcttgaaaca
    19621 tggcttctcg gcttgcttct ccctcacaaa aacataagca ctcttcttgt tctgctcctg
    19681 ctttttcttt aaaggaaagc ttgttttttc tcattccttc acttcctttt cagacataca
    19741 ctgctcacgc agatataaca gaatatggaa gggtaacgtg tttgcttgta caaattgctg
    19801 agggtaaaag cttctttttg aaaatatatc tccaaacatg cggtgtaacg aaagaaaaaa
    19861 ttgcggtttt tttgcgcttc tcacaagaat gttgatgata aaatatgaca tatatagaat
    19921 tatgaaggga gggatttgca aacgtgtcag gtgtcatatc ttcttcttcc atcggagaaa
    19981 agattaacga atggtatatg tacatacgcc gattcagcat acccgatgca gaatatttgc
    20041 gacgagaaat caagcaagag ctggatcaaa tggaagaaga tcaagacctt catttgtact
    20101 attcactaat ggagtttcgg cacaacctga tgcttgagta ccttgaaccg ttagaaaaaa
    20161 tgaggattga ggaacagccg agactgtctg atctgctgct tgagattgat aaaaaacagg
    20221 ctcgtttaac tggtctgctt gagtactatt ttaatttctt cagaggcatg tatgagctgg
    20281 atcgccgtga atatgtatta gccattcaat tctttaaaaa agctgagagc aagctggttt
    20341 ttgtgaaaga taaaatcgat aaagctgaat tctttttcaa aatgtcagaa gtctattatt
    20401 atatgaaaca aacttatgtc tccatggact atgcacgtca agcattcgaa atatacagtg
    20461 aacagactac atatgatatc agaatgattc aatgccagtc cttattcgga gccaactttt
    20521 tggatttaaa acaatacgaa aaagcaattg cccattttca aaaagccttt acacttgcaa
    20581 aaacagagca gcagccccaa ttaatgggaa gaacacttta taacatagca ctctgcaagc
    20641 aaaaccaaaa cagttttgaa tcagcgatag agtatgtaaa aaaatctatt caagtatttg
    20701 aaggatctaa aatgcttcct tcattgccac aagctttttt cctaattaca caaatttatt
    20761 ttaaattagg taagattgat aacgcctgtg aatatcataa aaaaggaaaa gagtattctg
    20821 cagctgcggg agataccgtg tatctaacgg agtttgaatt tttggaatct ttatacttgt
    20881 ctggaccgga tgaggaacgg atagaaaaat gttttgtttt tcttgaaagt aaaatgatgt
    20941 atgcagatat tgaggacttc gcacttgatg ttgctaaata ttatcatcaa caggaaaatt
    21001 acaaaaaagc atctcattac tttttaaagg ttgaagaagc aagacagcac attcaagggg
    21061 gggtgaattt atatgaaatg gaagtataaa ttattactcg cttgtttagc tgtgagtgct
    21121 gtatttatca cagtcgaagt atcaaattca tcaacagaac attttgatgt tgcgcaacgc
    21181 gccatgatct aaaccgccgt ccatcggcgg tttttttgtc ccctctttac ccagtctccc
    21241 aatccatgct atgatttttt caataatctt aaaaatagtg gaaatgcagc atgtctctaa
    21301 aaagtgtgag aacccacttt acacagtgga atcgagaaaa tgatgtgacg gagttcgaaa
    21361 cgtcgagcgc gacagtgttg aacagacagc tgagacgatc ggcgtaagcc cgactagaat
    21421 cgccaagacc ctgtccttca gaggggaagg agatcaggcg attctgattg tggcagccgg
    21481 cgatgccaag attaataaca aaaagttcag gcaaacattt ggctttaaag caagagtgct
    21541 ctctcctaat gaggtactgg agcagacagg ccatgaaatt ggaggtgttt gcccatttgg
    21601 gttggctcat ga
//
