LOCUS       NZ_CP023257            20825 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain TLO3 chromosome, complete genome.
ACCESSION   NZ_CP023257
VERSION     NZ_CP023257.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4072939)
  AUTHORS   Zhang,X.
  TITLE     Oral bacillus subtilis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4072939)
  AUTHORS   Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2017) Key Laboratory of Oral Diseases of Gansu
            Province, Northwest University for Nationalities, No. 1
            Xibeixinchun, Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-APR-2017
            Assembly Method                   :: SOAPec v. MAY-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 136.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002290305.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:20:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,325
            CDSs (total)                      :: 4,204
            Genes (coding)                    :: 4,004
            CDSs (with protein)               :: 4,004
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 140 of 200
            Pseudo Genes (incomplete)         :: 65 of 200
            Pseudo Genes (internal stop)      :: 36 of 200
            Pseudo Genes (multiple problems)  :: 37 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:53:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1181232
            Orig. end                         :: 1202057
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023257.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20825
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20825
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20825
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10825](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10825
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(44..277)
                     /gene="gerPB"
                     /locus_tag="CLD04_RS06225"
                     /old_locus_tag="CLD04_06225"
     CDS             complement(44..277)
                     /codon_start=1
                     /gene="gerPB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388952.2"
                     /locus_tag="CLD04_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06225"
                     /product="spore germination protein GerPB"
                     /protein_id="WP_003233090.1"
                     /transl_table=11
                     /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGSY
                     VEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR"
     gene            complement(292..513)
                     /gene="gerPA"
                     /locus_tag="CLD04_RS06230"
                     /old_locus_tag="CLD04_06230"
     CDS             complement(292..513)
                     /codon_start=1
                     /gene="gerPA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388953.1"
                     /locus_tag="CLD04_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06230"
                     /product="spore germination protein"
                     /protein_id="WP_003233088.1"
                     /transl_table=11
                     /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNTG
                     DSLKVMNYQNATNVYDNDAVDQPIVANA"
     misc_feature    complement(925..939)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.18"
                     /tool="antismash"
     misc_feature    complement(926..941)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.96"
                     /tool="antismash"
     gene            complement(935..1105)
                     /gene="yisI"
                     /gene_synonym="pchI"
                     /locus_tag="CLD04_RS06235"
                     /old_locus_tag="CLD04_06235"
     CDS             complement(935..1105)
                     /codon_start=1
                     /gene="yisI"
                     /gene_synonym="pchI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388954.1"
                     /locus_tag="CLD04_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06235"
                     /product="aspartyl-phosphate phosphatase YisI"
                     /protein_id="WP_003233086.1"
                     /transl_table=11
                     /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEEM
                     IFGRYLENSRM"
     misc_feature    complement(1188..1208)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.84"
                     /tool="antismash"
     gene            complement(1251..2174)
                     /gene="yisJ"
                     /locus_tag="CLD04_RS06240"
                     /old_locus_tag="CLD04_06240"
     CDS             complement(1251..2174)
                     /codon_start=1
                     /gene="yisJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388955.1"
                     /locus_tag="CLD04_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06240"
                     /product="CotH kinase family protein"
                     /protein_id="WP_017696569.1"
                     /transl_table=11
                     /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKTSY
                     EISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPAVSYSFLTINGQPEGI
                     YLNIKNHQPAGKTSYGVKTADPRVPLSLFNNDSSAFVHEFFILIRTAGDDELAERIKLY
                     LDVKLFFLWLIGNACTNQGFYYTFCLNESGRLYVSPIETRSLAVQEWYDEDPLLTKGKT
                     LSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIKKSPFQ
                     IEKEQTNILREIEERQDFLQAHLARL"
     gene            2329..3234
                     /gene="mblK"
                     /locus_tag="CLD04_RS06245"
                     /old_locus_tag="CLD04_06245"
     CDS             2329..3234
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mblK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388956.1"
                     /locus_tag="CLD04_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06245"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_017696568.1"
                     /transl_table=11
                     /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLIE
                     CIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYRDH
                     AIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGTRIS
                     KDDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSTIQEPERLKV
                     ETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTPPKFLR
                     SGDKIDITIDPIGTLSNQIG"
     misc_feature    3267..3281
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.4"
                     /tool="antismash"
     gene            3350..3706
                     /gene="yisL"
                     /locus_tag="CLD04_RS06250"
                     /old_locus_tag="CLD04_06250"
     CDS             3350..3706
                     /codon_start=1
                     /gene="yisL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388957.1"
                     /locus_tag="CLD04_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06250"
                     /product="YisL family protein"
                     /protein_id="WP_003244937.1"
                     /transl_table=11
                     /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYILI
                     ILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLLLT
                     VLLGLHLPIGFQLF"
     gene            3874..6558
                     /gene="wprA"
                     /locus_tag="CLD04_RS06255"
                     /old_locus_tag="CLD04_06255"
     CDS             3874..6558
                     /codon_start=1
                     /gene="wprA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388958.1"
                     /locus_tag="CLD04_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06255"
                     /product="cell wall-associated protease WprA"
                     /protein_id="WP_095843617.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.3e-47, bitscore:
                     158.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRRKFSSFVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENGK
                     EQTGAMKEPEQVKWYKVTPGATDIQKHSHMALTVKSDSVLNVSVYPSKEKALKDETFEM
                     YRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGTKKQ
                     PSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAPFIVA
                     KLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQSVPSF
                     LKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLSSVHNEM
                     KGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAAATLSKMS
                     NVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSKRKLNDTLI
                     AVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQSDNGYSMTG
                     LNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSRVLEFALKYAA
                     DKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKGLDISAPGSDIP
                     SLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKTADDISFESVDGG
                     EEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNKLESTQTAVRGNAK
                     EGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYVKATKGDAKTSYKVVVVKGK
                     PSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADAKGTFSVKIKKQKAGT
                     VLYVTAADTDKKESKEAKVVVEK"
     gene            complement(6589..7170)
                     /gene="yisN"
                     /locus_tag="CLD04_RS06260"
                     /old_locus_tag="CLD04_06260"
     CDS             complement(6589..7170)
                     /codon_start=1
                     /gene="yisN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388959.1"
                     /locus_tag="CLD04_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06260"
                     /product="DUF2777 domain-containing protein"
                     /protein_id="WP_072692655.1"
                     /transl_table=11
                     /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDILL
                     ADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALLDS
                     LDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQHHY
                     SSEGTGDRFEWTASNGKRSIMYSAVQRGRK"
     misc_feature    complement(7153..7169)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            7316..9160
                     /gene="asnB"
                     /locus_tag="CLD04_RS06265"
                     /old_locus_tag="CLD04_06265"
     CDS             7316..9160
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388960.2"
                     /locus_tag="CLD04_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06265"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_041345115.1"
                     /sec_met_domain="GATase_7 (E-value: 2.1e-46, bitscore:
                     154.8, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 6.4e-99, bitscore:
                     329.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHVL
                     FGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSDTE
                     VLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTNEGSSFLFGSE
                     IKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGVFKGIKEIRPAHALTFSKDGLNIWR
                     YWNVESEKHTDSFNDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAIAAGHF
                     EKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTETFGTTHHKCVISQKDLVD
                     HLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFHMADVESG
                     FPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKARRQLFYLN
                     MLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNREKGILRKALE
                     GILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRKQLDQLLETEG
                     SSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER"
     gene            complement(9266..9769)
                     /gene="bstH"
                     /locus_tag="CLD04_RS06270"
                     /old_locus_tag="CLD04_06270"
     CDS             complement(9266..9769)
                     /codon_start=1
                     /gene="bstH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054576.1"
                     /locus_tag="CLD04_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06270"
                     /product="DinB family protein"
                     /protein_id="WP_072692640.1"
                     /transl_table=11
                     /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFHI
                     IDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELVSV
                     PWKTGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSYCRNA
                     GAIR"
     misc_feature    9748..9762
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.73"
                     /tool="antismash"
     gene            10001..10825
                     /gene="farP"
                     /locus_tag="CLD04_RS06275"
                     /old_locus_tag="CLD04_06275"
     CDS             10001..10825
                     /codon_start=1
                     /gene="farP"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388961.1"
                     /locus_tag="CLD04_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06275"
                     /product="farnesyl diphosphate phosphatase"
                     /protein_id="WP_072692639.1"
                     /sec_met_domain="phytoene_synt (E-value: 5.1e-30, bitscore:
                     102.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.9e-34,
                     bitscore: 117.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQASW
                     AVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGNQHLWKAFDHAYRTFTLESEPFREF
                     IAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQLVR
                     FLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEECQDA
                     LPLFPQYSQKTVKAALHLHRAVIEKIRAKQHDVFQHHFALTETEVKQILSDI"
     gene            complement(10856..12223)
                     /gene="yisQ"
                     /locus_tag="CLD04_RS06280"
                     /old_locus_tag="CLD04_06280"
     CDS             complement(10856..12223)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="yisQ"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388962.1"
                     /locus_tag="CLD04_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06280"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_014476390.1"
                     /transl_table=11
                     /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTLM
                     LSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSIGA
                     NFFISLAISAVVFFAAVPLLHMMGLSNALMPDAKVFLQVVGGLSFIQALIMTFSAILKS
                     YGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAMIVIV
                     NKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGAQALTT
                     KVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIAAATSVL
                     MTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDAKFPVYMA
                     MISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWIQKGMA"
     gene            12347..13210
                     /gene="yisR"
                     /locus_tag="CLD04_RS06285"
                     /old_locus_tag="CLD04_06285"
     CDS             12347..13210
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="yisR"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388963.1"
                     /locus_tag="CLD04_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06285"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_015715646.1"
                     /transl_table=11
                     /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQGT
                     LYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTTKGGSNWS
                     ELQQEKGSFEEPARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILFEEL
                     MLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQQVLG
                     VTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPIEYRKI
                     VSRKVQ"
     gene            13228..14241
                     /gene="degA"
                     /gene_synonym="iolQ"
                     /locus_tag="CLD04_RS06290"
                     /old_locus_tag="CLD04_06290"
     CDS             13228..14241
                     /codon_start=1
                     /gene="degA"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /gene_synonym="iolQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388964.1"
                     /locus_tag="CLD04_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06290"
                     /product="transcriptional regulator DegA"
                     /protein_id="WP_017696562.1"
                     /transl_table=11
                     /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEMA
                     YTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQILICSTDYDPKK
                     ETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEHITIAMISQDKPLLPMDIVVID
                     DVRGGYVAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLIIQTR
                     FYLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFDNTILA
                     EMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSPLNT"
     misc_feature    14378..14387
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(14398..14409)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            14450..15478
                     /gene="iolX"
                     /gene_synonym="yisS"
                     /locus_tag="CLD04_RS06295"
                     /old_locus_tag="CLD04_06295"
     CDS             14450..15478
                     /codon_start=1
                     /gene="iolX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="yisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388965.1"
                     /locus_tag="CLD04_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06295"
                     /product="scyllo-inositol 2-dehydrogenase"
                     /protein_id="WP_017696561.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.2e-33, bitscore:
                     114.4, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.8e-27,
                     bitscore: 93.8, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHQVRCAVLGLGRLGYYHAKNFVTSVPGAKLVSVGDPLKGRAEQ
                     VAREFGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTLSL
                     EESRAVSEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGAPPA
                     EFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALTYIEF
                     DSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDIIPDFQT
                     RFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRSGRPVQLDVKRAYT
                     GM"
     gene            complement(15528..16037)
                     /gene="bstC"
                     /locus_tag="CLD04_RS06300"
                     /old_locus_tag="CLD04_06300"
     CDS             complement(15528..16037)
                     /codon_start=1
                     /gene="bstC"
                     /gene_functions="other (smcogs) SMCOG1250: DinB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388966.2"
                     /locus_tag="CLD04_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06300"
                     /product="DinB family protein"
                     /protein_id="WP_026113686.1"
                     /transl_table=11
                     /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDVL
                     LHMCRADYIWLNVLSGVAYQEIIDSAGKLESAQGNMAAIKQHAAELESQYHDFFSRQTN
                     LEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLGHSGVPTDYMYYLYE
                     KRESKG"
     gene            complement(16087..16749)
                     /gene="yisU"
                     /locus_tag="CLD04_RS06305"
                     /old_locus_tag="CLD04_06305"
     CDS             complement(16087..16749)
                     /codon_start=1
                     /gene="yisU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388967.1"
                     /locus_tag="CLD04_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06305"
                     /product="LysE/ArgO family amino acid transporter"
                     /protein_id="WP_015252394.1"
                     /transl_table=11
                     /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQQ
                     GAWQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYMGW
                     VTWNSRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEKWLF
                     MAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLFCN"
     gene            16816..18270
                     /gene="yisV"
                     /locus_tag="CLD04_RS06310"
                     /old_locus_tag="CLD04_06310"
     CDS             16816..18270
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (121-462). E-value: 1e-35.
                     Score: 115.5. Matches aSDomain:
                     nrpspksdomains_CLD04_RS06310_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="yisV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388968.2"
                     /locus_tag="CLD04_RS06310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06310"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_072557141.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.7e-34, bitscore:
                     115.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSQWQPSRKSDIPLHRQIEQYMKDKILHGEWAVGTKIPSQRTL
                     ADMFQVNRSTVTAAIDELTSQGLLEGRRGGGTKVVNSTWSVLAAEPPLDWSDYVRSGIH
                     RANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGALSLGYEQPKGN
                     RQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYLQSLH
                     VFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQRRKEII
                     SLSKKEQLPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGTFSKTVSPGLRIGWLAG
                     PEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRDAAVHFLE
                     RYAGDIATWRIPAGGFYIWVTFHKNLPVSHFFYGLLKRQVLVNPGYIYDGEDRNSIRLS
                     YSYASLGDLETGIKAAAETARCLMMS"
     aSDomain        17179..18201
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLD04_RS06310_Aminotran_1_2.1"
                     /evalue="1.00E-35"
                     /label="CLD04_RS06310_Aminotran_1_2.1"
                     /locus_tag="CLD04_RS06310"
                     /protein_end="462"
                     /protein_start="121"
                     /score="115.5"
                     /tool="antismash"
                     /translation="DIIRLGTGELSPDLVPADTIGRMFQQINPGALSLGYEQPKGNRQL
                     REAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYLQSLHVFQ
                     SAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQRRKEIISLS
                     KKEQLPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGTFSKTVSPGLRIGWLAGPEP
                     VIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRDAAVHFLERYA
                     GDIATWRIPAGGFYIWVTFHKNLPVSHFFYGLLKRQVLVNPGYIYDGEDRNSIRLSYSY
                     A"
     gene            complement(18278..18916)
                     /gene="yisX"
                     /locus_tag="CLD04_RS06315"
                     /old_locus_tag="CLD04_06315"
     CDS             complement(18278..18916)
                     /codon_start=1
                     /gene="yisX"
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388970.1"
                     /locus_tag="CLD04_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06315"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_014479410.1"
                     /transl_table=11
                     /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGEDI
                     ERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVGMN
                     VAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSNTVLQQTHFDGCELEGA
                     SFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV"
     gene            19122..19928
                     /gene="yisY"
                     /locus_tag="CLD04_RS06320"
                     /old_locus_tag="CLD04_06320"
     CDS             19122..19928
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-254). E-value:
                     2.9e-34. Score: 110.7. Matches aSDomain:
                     nrpspksdomains_CLD04_RS06320_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="yisY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388971.1"
                     /locus_tag="CLD04_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06320"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_041335509.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-26, bitscore: 91.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-17, bitscore:
                     61.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGHYVKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNELP
                     KRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGCAIAIR
                     YMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKSDRPKTLADLGKQ
                     FFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGRKDRI
                     APFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS"
     aSDomain        19188..19883
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLD04_RS06320_Abhydrolase_1.1"
                     /evalue="2.90E-34"
                     /label="CLD04_RS06320_Abhydrolase_1.1"
                     /locus_tag="CLD04_RS06320"
                     /protein_end="254"
                     /protein_start="22"
                     /score="110.7"
                     /tool="antismash"
                     /translation="PIIFLHGWPLNHKMFEYQMNELPKRGFRFIGVDLRGYGQSDRPWE
                     GYDYDTMADDVKAVIYTLQLENAILAGFSMGCAIAIRYMARHEGADVDKLILLSAAAPA
                     FTKRPGYPYGMRKQDIDDMIELFKSDRPKTLADLGKQFFEKKVSPELRQWFLNLMLEAS
                     SYGTIHSGIALRDEDLRKELAAIKVPTLILHGRKDRIAPFDFAKELKRGIKQSELVPFA
                     NSGHGAFYEE"
     gene            complement(19956..20555)
                     /gene="cysC"
                     /locus_tag="CLD04_RS06325"
                     /old_locus_tag="CLD04_06325"
     CDS             complement(19956..20555)
                     /EC_number="2.7.1.25"
                     /GO_function="GO:0004020 - adenylylsulfate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000103 - sulfate assimilation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cysC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388972.1"
                     /locus_tag="CLD04_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLD04_06325"
                     /product="adenylyl-sulfate kinase"
                     /protein_id="WP_017696558.1"
                     /transl_table=11
                     /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLAN
                     AVDEKLYRKGIQSYVLDGDSIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMILT
                     AFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKELYKKARNGKIKHFTGIDS
                     PYEAPLSPDFIIESDQTSISDGADLIINALQNRGII"
     misc_feature    complement(20549..20559)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(20778..20787)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
ORIGIN
        1 ggaaacagat tgatcataca tgttcttcac ctctttcata tgattaacgg ccaggaggct
       61 ggagcgggac caatgaacct gtgtcgggct cctgcagctg gagcggttgc cctgagccag
      121 aaacttctgg tgccggctct acatagcttc ctgtattata caaatttgac agtgacttga
      181 ttgatccggc gctcccgatt tgcagaatgg aggagttgct gattgattcc agccggagat
      241 agttgatttg aatggtttga ttaatataga agttcatgag cctcactcct tttacgcatt
      301 ggccacgatc ggctgatcaa ccgcatcatt gtcatacaca ttcgtcgcgt tttgataatt
      361 catcaccttg aggctgtcgc cggtattaaa gctgccagca ccggcaaacg ttctgacctg
      421 agcctgagga gaaatcgtaa tgcagtcccc gatgtgaacg actccgctcg taccaatcgc
      481 attaatttta aacgctccga caatggccgg catacgagca catcctttgt tgaaaaattg
      541 aaaaaagaca ggtaaagtga aatgacaatt ctgatttcaa ttgggctatt cacgatagct
      601 tatgacaaac gcacatatgt gtgagagata tttaaagggg atatatcggc tcttggtgaa
      661 agcgttttat ttttcgggcc gttatgttta aacatggcaa aagaggatgt tgggtataaa
      721 ttgaacggaa atgcggcgaa ggatgccgct atccgcctat ggtgattttt gtttatttct
      781 ttggtgtttt tgcgtgtaga atgctttttg gagtatgtcg tgctgcggta ttcgattttt
      841 gggctggcac attctcgccc tgaggtatat cccagaagtg ctgagcaaaa agcggagtta
      901 catgtggtgt attctactcg ttatagaaaa tgatttacat acgggagttt tcaagatatc
      961 tcccaaaaat catttcttct ttaatccggg tattcagcag gatatcgagc tcttggctgc
     1021 attgaatcgt ttcctttgaa ttcatgccgt atttttgtgc ggtttcaatt agtgtgatcc
     1081 tcatttcttc aattttactg ttcattacgc tatctccaat tctagatttt attttgatat
     1141 aaatacagga tatcgttagt ataatctatt ttggctcaaa aggttgcctt tcgtcaattt
     1201 gactaaaaaa gcgacaattt ttgctgcggc cttttttaat ggagaaagga ctaaagtctt
     1261 gctaagtgtg cttgcaaaaa gtcctgccgt tcctcaattt ctctaagtat gttggtctgc
     1321 tccttttcga tctgaaaggg gctttttttg ataaaaggat catcagcagc actttgacaa
     1381 atgtcaaggt gccattcgtt gatgagagga gataatcgtt caatagtaaa cgaccgcttc
     1441 agcacgtttt tcattaatgt gtgatattgc gaccggaagg cgggaatgga tagaagcctt
     1501 gacgaaagcg tctttccttt tgtcagaagc gggtcttcgt cataccattc ttgtacggca
     1561 agcgatcttg tctctatcgg ggaaacgtaa agccggccgg attcgtttaa acaaaatgtg
     1621 tagtaaaagc cttgattggt gcaggcgttg ccgatcagcc acaaaaaaaa cagcttgaca
     1681 tccagataca atttaatcct ttcagccaat tcgtcatctc cggctgtgcg gatcagtatg
     1741 aaaaattcat gtacgaatgc cgaggaatca ttgttaaaaa gggacaacgg aacccttgga
     1801 tcggccgtct tcactccgta actcgtttta ccggctggct gatggttctt gatgtttaaa
     1861 taaatgcctt caggctggcc attgatggtc agaaagctgt acgagacagc gggagcaggt
     1921 acgccgatct ggtcaaaaaa acaataggcg agtctgcgcc gcatcaggga cggatcatcc
     1981 tgttctgcat tcaaaaaaag tgtcctttca ccaagcagag acttttccca gctgatttca
     2041 taggatgtct tttccgctct gtcacgctgt gtgagaagaa tgggagaaac agatcgatct
     2101 gttacgaaaa gccccttggc agtacctttc cttttcagct gctcccgatg aaaaaataaa
     2161 tgcacgcgct ccatattctt tcctccttct caaaacgaca tttgtatgat atgtagagca
     2221 agcccgtcct gaaacgaaat gaaaacggaa atgagaaaaa gggatttcag cattcgacag
     2281 agaatacatg aaggagcatt ctgatttaaa agatgatgga ggaataacat gaaatttgcg
     2341 acaggggaac tttacaaccg aatgtttgtc ggcctgatca ttgatgatga gaaaattatg
     2401 gatttgcaaa aggctgaaaa aaaactgttt gaacttgaga cgattccggg atcgctgatt
     2461 gaatgtatcg cagaagggga taaattcgtt gcgcatgcaa ggcagctggc cgagtgggca
     2521 aagaaaccga atgatgagct gggatcattt atgtattcat tatctgaggt gaagctccat
     2581 gcacccattc cgaagccatc aaaaaatatc atctgcatcg gcaaaaacta ccgggatcac
     2641 gcgattgaaa tgggaagcga ggctgatatt ccggagcatc cgatggtatt tacaaaatcg
     2701 ccggtaacgg ttacggggca tggtgatatc gtaaagagcc atgaagaggt tacctctcag
     2761 cttgattatg agggagaact tgctgtcgtg atcggaaaaa gcgggacccg catttcaaaa
     2821 gacgatgcat atgaccatgt tttcggatat acgattgtga atgatatcac ggcgcgtgat
     2881 ctgcaaaaaa ggcataagca gttttttatc ggaaaaagct tggatacgac atgtccgatg
     2941 gggcccgtgc ttgtacataa atcaacgatt caggagccag agcgcctcaa ggttgaaaca
     3001 agagtcaacg gcgagctgcg ccaatccggt tcggcaagcg atatgatctt ttccattccg
     3061 gaattaattg aaaccctctc aaaggggatg acgcttgaag cgggcgacat cattgccacc
     3121 ggtacgccgt ctggtgtcgg caaggggttt acgcctccaa aattcttgcg gtcaggtgac
     3181 aaaattgata ttacaattga cccgatcgga acgctgtcaa accaaattgg ctgaataaaa
     3241 ctcgagggcg gacccggacc cgcccgtttt ttctgacaat catctttgtg gcagaggaca
     3301 agttcatggt actataagtg gggtaattta tctgataggg ggaacatata tgacacacct
     3361 acatattacg acatgggtgg tagcgctgat tctgcttttc gtcagctact cgctgtattc
     3421 gtcaggaagt gcaaagggcg caaaaatcac tcatatgatt ctgcggttat tctatatcct
     3481 tattattttg acaggagctg agctgtttgt ccgtttcgcc aactggaacg gagaatacgc
     3541 cggcaaaatg attctgggca ttatcaccat cggcctgatg gaaatgctcc tcatccgcaa
     3601 gaaaaaagaa aaatcaacag gaggcctgtg ggtcggcttc gtcattgtcc ttttgctgac
     3661 agtgctgctc ggtctgcatt tgccaatcgg ttttcaattg ttttaataga aaaacctatg
     3721 aacccggctc tttgatagag ttgggttttt ttatatttat ccctttatat tccaaatcat
     3781 ttaaaataac cttaaaattc cctgtaagcg gtatctcgtc ctatgaaatt atgatacctt
     3841 caaggagatt cattattttg caggagggat aacatgaaac gcagaaaatt cagctcgttt
     3901 gtggcggcag tgcttatttt tgcactgatt ttcagccttt tttctccggg aaccaaagct
     3961 gcagcggccg gcgcgatcga tcaggcggct gctctggaaa acggcaaaga gcagacaggc
     4021 gccatgaagg agccggaaca ggtgaaatgg tacaaagtga ccccgggagc aacggatatt
     4081 cagaaacact cacatatggc actgaccgta aagagtgatt cagtactgaa tgtatctgta
     4141 tatccaagta aggaaaaagc gcttaaagat gagacgtttg agatgtaccg ttctttcaca
     4201 gcggaggatg gaaaaagcga agtcattttt ccatacgcgt ggagcggccc ttactatgta
     4261 aaagttgaat acctcggaga agaagagcca gaggacggcg gaacggcaga agcagctgcg
     4321 gaagccaagt atacgattgg gtataaaggc accaaaaaac agccgtcaga tttagaagag
     4381 gaagaagctt gtccggttga aatgagtgtc gatcagaaga aatcaggaaa aggcatcctg
     4441 gataagttga gatcgattcg tgatgagcag ctgagccaaa cagcagaagg caaagaactg
     4501 acaagccttt attacaaagc agcaccgttt atcgttgcaa aactcgcact caataaaaca
     4561 gcaagaaatg aaatctatca ggatcttgtg acattaaagc cgttatttga cgatgtgtca
     4621 gaaaacggag catcatcttc gtataaggtc actgaaaagg atcaaaaagc gatcaaccgg
     4681 ctatatgata aagctttaca atcagtcccg tcattcctta aagaggagat aaagaaacaa
     4741 gcggaccgac taaatatgaa gcagctgcaa ggcaaaacag ccggagccat tttaacagaa
     4801 aacaatattg cagcaaaaag tgaagttcag acaacaaagg ttattttcaa ggtgaaggac
     4861 aataaaagcc tctcatccgt acataatgaa atgaagggct tttctgcaag cgcgcaatcg
     4921 aaaaaagaca tatctaatgt gaaaaaggca aagaaactgt ttgacaatct gtattcattt
     4981 gaacttccga aagatgagaa acagaacggc gcatatacgg caagcgccaa aagggtcaaa
     5041 agcgctgctg cgacactatc caagatgtcc aatgtagagt ttgcggaacc cgtgcaggaa
     5101 tacaaaagcc tggcaaacga tattcagtac ccttatcaat ggccgcttaa aaacaacggt
     5161 gaaaacggcg gtgtcaaaaa tgcggatgtg aaatatgagc ctgccaacac attgctgtcc
     5221 aaacgcaagc ttaacgatac actcattgca gtagtagaca caggcgttga cagcacgctt
     5281 gccgatttaa aaggaaaagt aagaacagat ctcggacaca attttgtcgg acggaataac
     5341 aatgcaatgg atgatcaggg gcatgggacg catgtcgcag gcattattgc ggcccaaagc
     5401 gataacggct attcaatgac tggattgaat gccaaagcaa aaatcatccc tgtaaaagtg
     5461 cttgattccg caggttccgg agatactgaa caaattgctc tcggcatcaa atatgctgct
     5521 gacaaaggag caaaggtgat taatttaagt ttaggcggag gctacagccg cgtacttgaa
     5581 tttgctttga agtacgcagc tgacaaaaat gtgttgattg ccgcagccag cgggaatgat
     5641 ggagaaaatg ccttatctta tcctgcatct tctaaatatg tgatgtcagt cggcgcaacg
     5701 aaccgcatgg atatgaccgc tgatttctct aactatggaa aaggtctgga catctctgct
     5761 ccagggtctg atatcccgag cttagtgccg aacggaaatg tcacgtacat gagcggaacg
     5821 tctatggcga cgccgtatgc tgccgctgct gcaggattgc tgtttgctca aaatcctaag
     5881 ctgaaaagaa cagaagttga ggatatgttg aaaaagacgg cagatgatat ttcctttgaa
     5941 agtgtcgatg gcggagaaga agagttgtat gacgattatg gcgatccgat tgaaattccg
     6001 aagacacctg gtgtagactg gcattcaggc tacgggcggc tgaatgtcat gaaggctgtc
     6061 agcgcagctg atttacagct taaggtcaac aagctggaaa gcactcaaac agctgtcaga
     6121 ggaaacgcga aggaaggcac acttatcgag gtaatgaacg gcaaaaagaa actcggcagc
     6181 gccaaagccg gaaaagacaa tgcgttcaag gttaatatcg cgactcaaaa acaggatcaa
     6241 gtactgtatg tgaaagcaac aaaaggcgat gcgaaaacat cgtataaagt tgtcgtcgtc
     6301 aaaggaaaac cttccggcac accgaaagta aacgcggtga aaacgaagga tacggcagta
     6361 aaagggaagg caaacagcaa agcgatgatc agagtgaaaa acaaatcaaa gaaagtcatt
     6421 gcttctgcca aagctgacgc aaaaggaacg ttttcggtga aaatcaaaaa acaaaaagcc
     6481 ggaacggtgc tgtacgtcac ggctgcggat acagataaaa aagaaagcaa ggaagcaaaa
     6541 gttgttgttg aaaagtaacc aaaaagcggt gctcgatgca ccgctttttt atttgcgccc
     6601 ccgttggact gctgaataca taatggatcg ctttccgttt gaagcggtcc attcaaaacg
     6661 gtctcctgtc ccttcgctgc tgtagtgatg ctgcatcgcg cattgtgcgg tgtcatttga
     6721 aaagtgataa aaggacacac cctgccccgc cgaagtattc gaaaagactc ctttattata
     6781 agaaaagacg caatcgaata ccgataagcc gaagctgtgc aagtgctgca gaaatgcgag
     6841 aaaggtttcg tcgtcaagtg aatccaaaag cgccataagc ggccgcttga ctgatttctc
     6901 atagcggatg cgttctccgc cggaaaggga gatgttttct gcaccgcatg ccaaaaccaa
     6961 cttgtcctga aagccggctt gctcccactt tcctttatga tggatccaga ttgggctgtg
     7021 ttggagactg tccgccagca gtatatcgcc ttcaccgttt tcgattaagc agatgccgtc
     7081 ttcaatgagg atggtgccgt attcccactt tcgttcctct gtatataaca attgtttccg
     7141 tttcatccat gctgtctcct ttttcttcat tcctctcttt tctttccaat tcaagcctgt
     7201 cccatacaac tcttttatgg acaaatcaac tatctgccta tagatgcata aacttactaa
     7261 ggtgctgaaa caaacgaaat tgttacgaaa gaaacgggat tggagctgat gtcacatgtg
     7321 tggaattacg ggttgggtcg attttaaaaa gcagctcgtc caggaaaaac aaacgatgga
     7381 cagaatgaca gacactcttt ccaaacgagg gcctgatgat tcaaacgttt ggggggagca
     7441 ccatgtttta ttcggacata aaagacttgc agttgttgat attgaaggcg gacgccagcc
     7501 gatggcgtgc acctataaag gggataccta caccattatt tacaatggcg agctttataa
     7561 cacggaagat ttgcgcaaag aattgcgggc gcggggccat caattcgagc gtacgtcaga
     7621 taccgaggtg cttctgcaca gctacatcga atggcaggaa gactgtgtcg accatctcaa
     7681 tggcatattc gctttcgctg tgtgggatga aaagcgtaat ctgctgtttg ccgcgagaga
     7741 ccgtctcggc gtaaagccgt ttttttacac gaatgaaggc tcttcatttc tcttcgggtc
     7801 ggaaatcaaa gcaatcctcg cgcaccctga tataaaagcg cgagtggaca gaacgggact
     7861 ttctgaaatt ttcgggcttg gaccgtccag aaccccgggc actggcgtat ttaaaggcat
     7921 aaaagaaatc cgcccggctc acgcgctgac attttccaaa gacggactta atatttggcg
     7981 ttattggaat gttgaaagcg aaaaacatac ggacagtttt aatgatacgg ttgccaatgt
     8041 cagatcgtta tttcaggacg cggtgacgcg gcagcttgtg tcggatgtgc cggtttgcac
     8101 attcttatca ggcggtctgg actcaagcgc aattacagcg attgcggcgg gccattttga
     8161 aaaggaagga aaagcaccgc ttcatactta ttcgattgat tacgaagaga acgataaata
     8221 ttttcaagca agcgcttttc agccgaatga tgacggacca tggattgaaa aaatgacaga
     8281 gactttcggc acaacgcacc acaaatgcgt catcagccaa aaagatctcg ttgatcattt
     8341 ggaggaagct gtactggtca aagacttgcc gggaatggcg gatgtcgact catccctgct
     8401 gtggttttgc cgggaaatca aaaaggactt tgtcgtcagc ctgtcgggag agtgcgcgga
     8461 tgagattttc ggcgggtatc cgtggtttca tatggctgac gtcgagtctg gctttccatg
     8521 gatgagatca acggaggagc ggatcaagct gctttctgac tcatggcaga aaaaattgaa
     8581 tctgaaagaa tacgtaaatg ccaaatatga agaaaccttg gcagaaacgc cattattaga
     8641 cggagaaacg ggtgtggata aagcaagaag acagctgttc tatttaaata tgctttggtt
     8701 tatgacgaac cttttggatc ggaaggatcg catgagcatg ggggcgagcc tggaagtgcg
     8761 ggtgccgttc gccgatcacc ggcttgtgga atatgtttgg aatattccgt gggaaatgaa
     8821 aatgcatgac aatcgggaaa aaggcatttt gcgcaaagcg cttgagggca ttttgcctga
     8881 tgacattctg tatcgcaaaa aaagcccgta tccgaaaaca caccatccgg aatatacaaa
     8941 aggcgtgagc gaatggctga aaacgatcag aagccaaaag gactccgtgc tccatacctt
     9001 gctggacaga aaacaattag atcagctttt agaaacggaa ggctcctcct tcaaggtgcc
     9061 gtggttcggg cagctcatga aggggcctca gctgatcgcc catcttgctc aaattcatac
     9121 atggtttgaa gcgtatcgca ttgatattga cgagaggtag gttcaatgca aatgtgatta
     9181 aaagccagag atgtatagat ttaaataaga aggatagatg agcagggaaa tatatgctct
     9241 atctatcctt ttttgtacaa cagcactatc gaattgcccc cgcattcctg caataagaat
     9301 gaataggttt taatgttctg ccgataaaac tagctgatac cgggcttaac tttaattccc
     9361 tagcccatac agaaagttga ccaatatggt gaatttcgtg agcgatgata tggtgtaata
     9421 tttcatctcg cgtatataaa acacctgtct tccaaggaac gcttacaagt tcatctttta
     9481 tttgatctga atgtgtttgt aaaacatcaa ttatttcagt tcggaatgta tttgagagag
     9541 atttcacttt attgagtgtt tgataatcag cgaactgaac agcgatatct tcttttcctt
     9601 ggatagcacg aatccaacta tattccacat caataatatg aaaaagggta tataaaatat
     9661 tctctactcc gccaagacgg tttttaagta attcttcagt ggttagttga tgacaccaag
     9721 taaaccattg atctctaacc tgccagttat attcaaaaaa tttcatcact gaactcactc
     9781 caatactatc atgtatcata acaattagcc cttttttccg tgattcctct attattgaag
     9841 tgatgattga gaaatgttta cattctacct gttgtatggc attaaaaata ataatgcata
     9901 tctcgtcgat gatgctgtgc gtcttgttac ttttacaaag taagaatcgg cattttcttc
     9961 atatacaatt aggaaaaaac atactagact tgaagaagca gtgatacata ggagtgagaa
    10021 aatgaaagag ataaaagaag cttaccagca atgcggacag attgttggcg aatacgcgcc
    10081 agcctgtttc aaagcattat catatctccc gctaaagcaa agacaagcct cttgggcagt
    10141 attgtcgttt tgccacacgg cggccagtgc agacgaaaag gtattgcccg catttgaagc
    10201 taaagctgat catgtttacc aaaggacaaa taacggtaat caacatctat ggaaggcttt
    10261 tgatcatgcg tatcggacct ttacattgga aagcgaacct tttcgggagt ttattgccgc
    10321 acaaaaagaa gacgccaagc cgtatgatga ccttgatgaa ctgctcatgt acgcatatcg
    10381 gacgggcggt gctgccggat tgatgctgct gccgatactg acacgccgaa aacaagatca
    10441 gctcaaacaa gcagccgtct ctctcggctt ggccatacag ctggttcgct tcttaagtga
    10501 tcttggcaca gatcagcaaa aaaaccgcat tccccgtcag gtaatgcagc aattcggcta
    10561 tacagaggct gatctccaaa aaggcaccgt gaataaggcg ttcacaatga cgtgggagta
    10621 tatcgctttt gaagcagaag cctaccttga agagtgtcag gatgccttgc cgctatttcc
    10681 gcagtattct caaaaaacgg tgaaagccgc tcttcatttg caccgggctg ttatagaaaa
    10741 aatccgggcg aagcagcacg atgtatttca acatcacttc gctctcacag agaccgaagt
    10801 gaagcagatt ctctctgata tctaaaaaaa cacccggcct tgattgagcc gggtgttatg
    10861 ccataccttt ttgaatccaa atacgtgagc gccatcttct gtacattaag attccccgga
    10921 cccattcatc cgcgataaaa gaaatccaaa tgccggcaag accgaaaccg aggtggatgc
    10981 cgaaaagata agcaagcggg aggccgatgc cccacattga aatcattgcc atgtaaaccg
    11041 ggaatttcgc atcccccgcg gcccgcagag agttaatgat aatgacatta aacgagcggc
    11101 ctggttcaag gataatggtc atggcaatca ataggcttgc agttgctata atgtcagggc
    11161 tttgtgtgaa gagtccgatc aggtcttttg aaaagatcgt catcaaaaca gaggtagccg
    11221 cagcaattcc gagtgcccaa tataagctct tcatgcagcg ctcataagcg gcatcaaatt
    11281 gtttgccgcc gatataacgg ccgattaaga tttgtgtacc ctggctgatc gcagtgccga
    11341 acagcaaaat aaacatcgta atattttgcg tatacacttt tgttgtcaac gcctgcgcgc
    11401 ccatgatggc gataaaatac gtgacaatca tttgcgaaag gttgtatgaa agctgctctc
    11461 ccgcagaagg aatgccgatt ttcagcagct tgcgcaaatg ctctttatgc atatgaaaga
    11521 cttttttcag cgacatcttc agctggatgc gtttgttgac aatcacaatc atcgcgatta
    11581 atccgatgac gcgggcgata gatgtggaca tggccacacc ggcaacgccg agaacaggaa
    11641 agccgaacaa accgaaaatc acaacaaagt ttccggcaat gtttaaaatg ttcatgccga
    11701 tagtgacaaa cattgtatct tttgtgtagc cgtagctttt taagatcgcg ctgaatgtca
    11761 tgattaaagc ctgaataaag gacagacctc cgacaacttg taaaaagact ttcgcatcag
    11821 gcatcagtgc gtttgataat cccatcatat gaagcagagg gacagccgcg aaaaagacga
    11881 cggcgctgat ggccaggctg atgaagaagt tggcgccgat tgacacataa gcgacttcca
    11941 tggcttcttt cttttgccgt gagcctagaa attgcgaaat gataacggtc gttcctgttg
    12001 cgataaagct gaacatcacg ataattaaat ttaaaatctg gttgctgacg ccgactgctg
    12061 ccacgctgtt atccgagtat tggctgagca tcagtgtatc ggcattaccc ataaacatat
    12121 ataatgagac ctcaatgaag atcggccaag taagcgaaaa taatgagaac gttttgtcag
    12181 cgggtttttt caaagcagtt gatttgaaga cagcttgttt catagtgtct aacccctttc
    12241 gtaaataaaa tcaacgtttt aaagtgtacc tccatttcct tataataaaa agggatagaa
    12301 acgatacttc ttgtaaaaat ccgacttaaa aaggaggatg attcaaatgc ctcgcatcct
    12361 gtttacagtc ccgccttttc cggtatttat cgcagccggg gaaggggttt ttaaaaaagg
    12421 agaaacccat gtgaaacgtg tattctccgt gtttgatctg atatatgtca aacagggaac
    12481 gttatatata acggaaaatg aaacatcgtt ttctgttgaa ggcggcgagt acatcttgct
    12541 ttctcccggt cttgaacact acgggacgaa gggcagtgat gaagcaacct cctactattg
    12601 gcttcacttc gatgaacatc gttatgaatt tacgacaaag ggaggcagca actggtctga
    12661 gcttcagcag gaaaaaggga gcttcgaaga gccggcccgc tacggattgg ccttgccgag
    12721 aaaaggcaag gtgcagcgcc cgcagtttat ggcgcagcag tttgaaaagc tgatcgatta
    12781 ctccgcggaa aactctgatt tgccgctcag aaagcaaatt ttatttgagg agctgatgct
    12841 gcatcttcaa aaagaagcgt tccaaatacc gtctgcgaaa gagcgggtag cctgggaggc
    12901 ggcccggtac ttacaggagc actataagga aaagacgaca atcaaggatc tgtcgctcgc
    12961 ccttcactat catcaggatt atgtgagccg ctgcatgcag caggtgctcg gcgtaactcc
    13021 ggcacaatac acgaaccggg tgagaatgac ggaagcgaag cgtcttttat cctctacaaa
    13081 tgataaaatg ggcgttattg cggaaacggt cggaatggaa gatccgacat acttttcaaa
    13141 actctttaag cagatagaag gcatttcacc aattgaatac cggaaaattg tcagccggaa
    13201 agttcaataa ccagacgagg gatgaacatg aaaacaacaa tttacgatgt ggcaaaggcg
    13261 gcgggtgtct cgatcacaac tgtgtcccgt gtgataaaca atacggggag aatcagcgat
    13321 aaaacacggc agaaggtcat gaatgtcatg aatgaaatgg catacacgcc caatgttcac
    13381 gccgcggctt taacgggaaa acgaacgaat atgattgctc tcgtggcgcc tgatatttca
    13441 aatccgtttt acggcgaact ggccaaaagc attgaggaaa gagcggatga gctcggtttt
    13501 caaatcttga tttgcagcac cgattacgat ccgaaaaaag aaacaaagta tttttctgtt
    13561 ttgaagcaga aaaaggtgga tggcattatt tttgcaacag ggattgaaag ccatgacagt
    13621 atgtctgctt tggaggaaat cgccagtgaa cacattacga ttgccatgat ttctcaggat
    13681 aagccgcttc ttccgatgga tattgttgtg atagatgacg ttcgtggcgg atatgtggct
    13741 gccaagcatc ttctgtcact cggccacacg aacatcgcct gcattatcgg agacgggtca
    13801 acgacaggcg aaaaaaatag aatcaaaggc ttccgtcagg cgatggagga agcgggcgtg
    13861 cccattgatg aatcacttat catccaaacg cggttttact tggaaagcgg caaggaagaa
    13921 gcgggaaaat tgctcgacag gaacgctccg actgctattt ttgccttcaa cgacgtattg
    13981 gcttgtgccg ccatacaagc tgcgagaata agaggcataa aagtgccgga tgatctttct
    14041 atcattggtt ttgataatac gatactcgca gaaatggcgg ctccgcccct gacaaccgta
    14101 gcccagccga taaaagagat ggggcggagc gtcatcgaac tgctggcaga agcaatagag
    14161 ggaaaacgaa aggcgaaaca aaaaatagtg cttccgcctg agcttgtagt cagacattct
    14221 acatcaccgc tcaacacatg agcccgctaa tgagcgggtt ttttcattat gacagttgaa
    14281 gccaaaaaac atattgcgtg taaaccaaag gcagtgtaaa atgaaaccat cttttgagaa
    14341 agcgcttgcg caaaaatggt aaagcggata gaaccgctgt ttttttagct gttaagagaa
    14401 agcgctttct cgaagcgagc ctgaaatgag ataaaggaga ggatgggacg tggaacatca
    14461 agtaagatgt gcagtattgg gattaggaag gctcggttat tatcatgcga aaaatttcgt
    14521 caccagtgtg ccgggggcaa agctggttag tgtcggtgat ccgttaaaag ggagagcaga
    14581 gcaggttgcc agagaattcg gtatcgaaaa atggtcagag gacccttatg aagtgttaga
    14641 agatcccggc attgatgctg tcattatcgt aacgccgaca agcacacatg gtgatatgat
    14701 catcaaagca gccgagaacg gcaaacagat cttcgttgaa aaaccgctga cattaagcct
    14761 tgaggaatca agagcagttt ctgaaaaagt gaaagagaca ggtgtcatct gccaagtcgg
    14821 ctttatgaga cgattcgatc ccgcatacgc agatgccaaa cggcggatcg acgctggaga
    14881 aatcggcaaa cctatctatt ataaaggctt tacgcgcgac caaggcgcgc ctcccgcaga
    14941 atttatcaaa cacagcggtg gaattttcat cgactgttcc atccatgact atgatattgc
    15001 ccgttatttg ctaggggcgg aaatcacttc tgtttcagga cacggcagga ttctgaacaa
    15061 tccgtttatg gagcagtatg gcgatgtgga tcaggcactg acgtatattg aatttgactc
    15121 cggcgcagcg ggggacgtcg aggcaagcag aacctctcca tacggacatg acatccgggc
    15181 ggaggtgatc gggacagagg gcagtatttt catagggaca ttgagacatc aacatgtgac
    15241 catcctatcg gctaaaggga gcagttttga tatcattcca gactttcaaa ctcgttttca
    15301 tgaagcctac tgcttggagc ttcagcattt cgccgagtgt gtccggaatg gaaaaacacc
    15361 gattgtgact gatattgatg cgacgatcaa tttagaagtg ggcatcgcag caaccaattc
    15421 ctttcgaagc ggcaggccgg tacagctaga tgtgaagcgt gcttatacag gtatgtaaaa
    15481 gctaaaatgt tgcatttgag gctttccgca aaaaaagcaa ggacatttta gcccttgctt
    15541 tctcttttct catataaata gtacatataa tcagtaggta cgcctgaatg gcccagctgt
    15601 ctcagcatgg cggttacgtt ccctctgtgg taagtgccgt gattgacgac atgcaggatg
    15661 gtgtctgcat aggttgattc cagtgtacct agtttcggat gttgcattgt gaaggtctgt
    15721 tctaagttcg tctggcggct gaagaaatca tgatactgtg actccagctc ggcagcgtgc
    15781 tgtttaatcg ctgccatatt accttgcgcg gactctaatt tgcctgcgct gtctataatc
    15841 tcttggtagg ccactcccga aagaacattc agccaaatgt agtcagccct gcacatatga
    15901 agcagcacgt cgctgacaga aggaaatacg ctctttactt cttgataggc agtttcctcc
    15961 ggcaggtttt cgatatgggt aaatattttc ttgtttgccc aagaatgata gtcataaaac
    16021 tgttttgcat cagtcatcag catgccccct tttctaagaa attcgttttt ttcatctgtt
    16081 tctctttcaa ttgcaaaaga gtgacacccc aaaatatcct gccgctgccc acattaccgc
    16141 tgcagagcat ttgtttacga tcagcataag cctgccgctc gtatctatcg tctgaaacaa
    16201 ccgacccgct attgcaaggc tgatgaacca aatccaagac acagcgatgc aggcggccat
    16261 aaagagccat ttctcaagcc ccgaatattg aagagagctc gtgccgatga cgccgatcgt
    16321 gtccagaatg gcatgcgggt ttaaaagaga aacagcggcc gcaaacgcag cttgcttttt
    16381 tggtgtgaac gtatgtttct cgttttggct tgtgttcgga cggctgttcc aagtcaccca
    16441 gcccatataa agcaaaaata aaaatccgcc ggccatcatg actgtctcaa acacaggcag
    16501 ctcctgcaca atgacagata cgcccgcaac ggctaatacg attaacaggg tatcgcagac
    16561 tgaagcactg atgacagctg ggagagcccg ccaaatatgc ttttgccacg cgccttgctg
    16621 aaaaataaac acattctgca ctcccagcgg caaaattaag ccaaacgcga gcacaattcc
    16681 gtgaatgatt gcattcatgc tgaaaaagct cctttcacat tttttttcaa tcataagaga
    16741 gattgtcact aaagtctcca gccatttggt tgggttagaa accagccaaa tgtataatgt
    16801 gtaaaaaagg ggggcatgac cttgtcgcaa tggcagccaa gccgaaagtc ggatattccg
    16861 ctgcatcggc agatcgaaca atatatgaaa gacaagattc ttcacggaga gtgggctgta
    16921 gggacgaaaa tcccctcaca gagaacgctg gccgacatgt ttcaagtcaa ccgcagcaca
    16981 gtcacagcag ctatagatga actcacgtct caaggcttgt tagagggaag aagaggcggc
    17041 ggtacgaagg ttgtaaacag tacttggagc gtgctggcgg ctgagccacc gcttgattgg
    17101 agcgattacg tccgttcggg cattcatcgc gccaattctt ccatcattca agctattaat
    17161 cagaacgaac caagagcgga tatcatcaga ttaggaactg gagaactatc accggatctt
    17221 gtgcctgctg acacaattgg acggatgttt cagcaaatca atccgggcgc cctgtcttta
    17281 ggatatgagc agccgaaagg aaaccgtcag ctgcgggagg cagtggccga ccatttaaaa
    17341 ggaaagaaga tccatgtgtc accgtctgca attttaattg tgtccggtgc acttcaggca
    17401 cttcagctca tctcaattgg acttttaaaa cgagattctg tcattttgac ggagaagccg
    17461 tcctaccttc aatccttgca tgtatttcaa tcagctggga tgcggcttcg cggcttgccg
    17521 atggatgatg aaggggtcaa agcggggctt gtttcttcta atcgaaaaca atatggagga
    17581 cagctgcttt acacgattcc gtcgtttcat aatccgacag gcacagtcat gtcagagcag
    17641 cgaaggaaag agatcatcag cctgtcaaaa aaagagcagc tgcccatcat tgaggatgat
    17701 gcgtacggtg atttatggtt tgaagaaaaa cctccgcagc cgttgaaagc aatggatcat
    17761 gagggcaata ttctgtatct gggcacgttt tcaaaaacgg ttagccccgg tctgcgaatc
    17821 ggctggcttg ccggtccgga gccggttatt gaaaggctgg cggacattaa aatgcagaca
    17881 gactacggat caagcggcct gtcccagtgg gcggctgccg agtggctgtc acaggggtat
    17941 tatgaagagc atctgacttg ggtacgcagg aagcttaaag aaaggagaga cgccgccgtt
    18001 cattttcttg agcggtatgc cggggacatt gccacgtggc ggattcccgc aggcggcttt
    18061 tatatttggg tgacatttca caaaaacctg cctgtcagcc atttctttta tggattgctg
    18121 aaacggcagg tgcttgtgaa tcccggctac atttatgacg gtgaagaccg aaacagcatc
    18181 aggctgtcat attcctatgc atctcttgga gatttggaaa ctggcattaa agcggcagct
    18241 gaaacagcac gctgcctgat gatgtcctaa gctttggtta tacgatgaca gctcccagtg
    18301 ccctggcgaa ggcaatcgcg tgctctggtg cgattttgca gcctttcaat ttgtcgaggg
    18361 agacatgaag ctgttcaaaa cggcacgtgc tgatgtccat gttttgaagg gacgtgccgg
    18421 taaagctggc gccttctaat tcgcatccgt caaagtgtgt ctgctggagc accgtattgc
    18481 tgcattcact ttgcataaga gcacagtgat caaatcgaac ttgtttcata tttgagtacg
    18541 aaaatgagct gaaatgtccg tggcattcct cgaatgaaac atttcgcagc gttgcttccg
    18601 ccacattcat tccaaccatt tttgactgct taactgaagt tctgtgaatg acagccccgc
    18661 tgaaatcggc gtttgataaa tcacattttt caaagatcac atcggtcagt tcaatatgcc
    18721 gaaaagacac atcgataaag acgacatttc tgaataccgt tttttcaaca cagagtcttt
    18781 cgatatcttc tccgcagatg gtacaatctt caaacaaatg catgctgatt acatcatcct
    18841 gcgtcacggc atcatgaaaa tctgcggttt gcaggttttc cggtatgttc ggtttttgaa
    18901 ttgcgatttt attcatgtga tgacatcctt tgctgtccga aaaacagagg cttccgggtt
    18961 caatttaata gatcgttaag gaaattgata catatagtaa atcgtgaaga gccttttctt
    19021 ggtacagcag cccgcttgtt ttgtaagcat aaatggaaag cttcctatac gtcaaggcgt
    19081 ttacagggcg aaaaagccaa agggaacagg aggaatgcgg aatggggcat tacgtcaaaa
    19141 ccgaggagca tgtgacactg tttgtagagg atatcggaca tggaaggccg atcatctttt
    19201 tgcacgggtg gccgttgaat cataagatgt ttgaatatca aatgaatgag cttccgaaaa
    19261 ggggatttcg ttttatcggc gttgatttgc ggggatatgg gcaatctgac cgcccttggg
    19321 aaggctacga ttatgacacg atggccgatg atgtgaaagc agtcatttat acgctgcagc
    19381 ttgagaatgc gattcttgcc ggtttttcaa tgggctgcgc cattgcaatc cgttatatgg
    19441 caaggcatga aggagccgat gttgataagc tgattttact gtctgcggcg gcccccgcgt
    19501 ttacaaaacg cccgggatat ccgtacggga tgaggaagca ggatattgac gacatgattg
    19561 aactattcaa aagtgatcgg ccaaaaacgc ttgctgattt aggaaaacag ttttttgaga
    19621 aaaaagtgtc tccagagctt agacagtggt ttctcaattt gatgctggag gcctcctcct
    19681 acgggacgat ccactcgggc atcgcattaa gagatgaaga tctcagaaag gaacttgctg
    19741 caatcaaggt gccgacgctg atcctgcacg ggagaaagga tagaattgcg ccgtttgatt
    19801 ttgcgaaaga attgaagcgc ggcatcaaac agtcggaatt ggttccgttt gcaaacagcg
    19861 ggcacggagc attttatgag gaaaaagaga agattaacag tttgattgcg cagttctcca
    19921 actcataaga aaaaacccga cattgatcgg gttttttata taattcctct gttttgcagt
    19981 gcgttaatga tgagatcagc tccatcggaa atagaggtct ggtctgactc aatgatgaaa
    20041 tcgggtgaaa gcggcgcttc atacggagaa tcgatcccgg tgaaatgttt gatctttccg
    20101 tttcgcgctt ttttataaag ctcttttgga tcgcgctgtt cacaaacatg cagcgggcac
    20161 ttcacataaa tttcgaagaa ctcaccttta ggaaagagcg ctctaaccat gtcccgatcc
    20221 tctctgaatg gagaaataaa agccgttaaa atcatttgcc cgctgtcgac aaacagcttc
    20281 gccacttctc cgatccggcg gatgttttca atcctgtcac cagtctgaaa tccaagatct
    20341 ttgtttaagc cgtggcggat actatcaccg tcaagcacgt agctctgaat gcccttgcgg
    20401 taaagctttt catcgactgc attggccagc accgattttc cagagccgga caaacctgta
    20461 aaccagagga cgcagctttt gtgtccgttt aaggactgtc tgtcagactt tgagatggca
    20521 gcgggatgcc aaatgatgtt cggattgtgt gtcattgcaa ttccccgctg ttttgcttga
    20581 tggcaacagg ctgttggtga agtcccttga tcagcacggc tgcgacccca ggccggctga
    20641 attctttagg cggctttttg ccttggcgga gaagctctct cacttttgtg cctgataagt
    20701 ggatgtggtc tcttgagctg tgcggacatg ttttggaggt gcccatgttt ccgcattttc
    20761 ggcaataaaa gctttgctca aaaaacagcg gcttgatgcc cagctcttcc tctgtgaatg
    20821 attga
//
