LOCUS       NZ_CP022753            25314 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Nocardiopsis gilva YIM 90087 chromosome, complete genome.
ACCESSION   NZ_CP022753
VERSION     NZ_CP022753.1
KEYWORDS    RefSeq.
SOURCE      Nocardiopsis gilva YIM 90087
  ORGANISM  Nocardiopsis gilva YIM 90087
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     The complete genome sequence of Nocardiopsis gilva YIM 90087
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2017) Yunnan University, School of Medicine, 2
            North Cui Hu Road, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 208.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002263495.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 21:04:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,549
            CDSs (total)                      :: 5,470
            Genes (coding)                    :: 5,345
            CDSs (with protein)               :: 5,345
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 61 of 125
            Pseudo Genes (incomplete)         :: 66 of 125
            Pseudo Genes (internal stop)      :: 5 of 125
            Pseudo Genes (multiple problems)  :: 6 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5945264
            Orig. end                         :: 5970578
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25314
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25314
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25314
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15314](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(239..799)
                     /locus_tag="CDO52_RS26030"
                     /old_locus_tag="CDO52_26015"
     CDS             complement(239..799)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017539874.1"
                     /locus_tag="CDO52_RS26030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26015"
                     /product="histidine kinase"
                     /protein_id="WP_198345793.1"
                     /transl_table=11
                     /translation="MDLMPYVDNLRRQLVVAAEAGNEDARAVAERLAAALEPAARLALL
                     DALSEAADEITRDFAPGSVEVRLRGGQTDFIVTPPPTDEPVDGPSDGGLASPRPSSGEA
                     AAEAGPVAESQPHDAEDGGTSRVTLRLPVHLKPQVEEAARREGLSVNAWLVRAVAAGLD
                     TGARRPDRGAGRQVGRGYTGWVR"
     misc_feature    complement(668..670)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(962..>1180)
                     /locus_tag="CDO52_RS29620"
                     /pseudo=""
     CDS             complement(962..>1180)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017365.5"
                     /locus_tag="CDO52_RS29620"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="proline racemase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GITFKGILHERVRSAGRDAVIPLIEGRAWITGVNQHILPDALFPC
                     GYTVGDMWGGSFFWVRKAPGQARGLQR"
     gene            complement(1199..1330)
                     /locus_tag="CDO52_RS29175"
     CDS             complement(1199..1330)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS29175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_017618490.1"
                     /transl_table=11
                     /translation="MSTYVITGATGNAPGTSSMTSPGPVLGRGRDGFGGRVGETHRE"
     gene            complement(1355..2827)
                     /locus_tag="CDO52_RS26035"
                     /old_locus_tag="CDO52_26020"
     CDS             complement(1355..2827)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618489.1"
                     /locus_tag="CDO52_RS26035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26020"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_017618489.1"
                     /transl_table=11
                     /translation="MTQVRDDRLDTALLRLIGVTLLGGIMGILDSTMVTVAADTLSQAF
                     GSSLSVISWASTGYLLALTVTIPITSWAVRRFGVKRLWLFGLVLFVAASLASALSWSVE
                     SLVLFRVVQGAGAGILDPLVLVILARAAGPSRAGRVMGMMGVVLSLGPVLGPVLGGLLL
                     DSMGWRSMFYINLPIGIVAFMLALRVIPTDPPGEQDARTPLDIVGFLLLAPGFAATVLA
                     LTQAGEHAEFAAPAVLAPLSIGLALLFGYVVHALRVRTTEPLIDVRLFTSRSFAASVTV
                     QGLVGLGTYAGLFALPLYYQIIHDHGAGGAGLLVAPLGLGSAFAMPIAGRLSDRLGARS
                     LVQGGAVLAAAGAFALTRIGAESGEAWSALAALVIGFGLGAVGAPTMGSLYRTLPAEKV
                     PQGSSVLYNLNQLGGALGVACAALILAAAGAGGVSGGIGGFQQVNWFLLAVAVVILAAS
                     PLLPGRLQEIPSTALDTASDADPAGERQQAHR"
     gene            2973..3638
                     /locus_tag="CDO52_RS26040"
                     /old_locus_tag="CDO52_26025"
     CDS             2973..3638
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618488.1"
                     /locus_tag="CDO52_RS26040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26025"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_017618488.1"
                     /transl_table=11
                     /translation="MNAAKTSETGSRSSPRGRIDKRQAILDAAFRVFARDGYGQSCVRE
                     IADEARVAKPTVYNHLGDKETLFHEALQAAVGRTVDRSLAALDKLRGSEGDLRATLEEV
                     GHLLLQNHCCAESQALRRLLNAEAARFPDLLNEIQSAGAQRIQNALADRLARLALAKRL
                     NIADPEQASEQFLALLTGPMELRSRLGTRQVPDTELRSVAGAARDTFLLAYAPQGEAD"
     gene            3719..4069
                     /locus_tag="CDO52_RS26045"
                     /old_locus_tag="CDO52_26030"
     CDS             3719..4069
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="CDO52_RS26045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26030"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_083919840.1"
                     /transl_table=11
                     /translation="MATALIADPDKGLGLETARRLIAAGHTVFLGSRDPEQDRSAAEET
                     GGRAVQLDVTSDASVRDTANTIADQTGHLDVLVNNAGITGPLQPHTRDTHPIGIGLRRF
                     VSELSRASAHAC"
     gene            complement(5226..5693)
                     /locus_tag="CDO52_RS26050"
                     /old_locus_tag="CDO52_26035"
     CDS             complement(5226..5693)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618486.1"
                     /locus_tag="CDO52_RS26050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26035"
                     /product="PPC domain-containing DNA-binding protein"
                     /protein_id="WP_017618486.1"
                     /transl_table=11
                     /translation="MRSHELTPGRTFGVVFDHGENFFETLNAFCRTNNVRQGYIPMFIA
                     GFAHVDIVGTCEQLTDPLAPVWSKVHLTNVEAVGGGTIAHDEANDTISPHVHVSVGLKE
                     HSATGHTSHLLAAEVQFLTEMVLVEITSPQMRRIPNPALYDVPLLHFDREE"
     gene            complement(5748..6761)
                     /locus_tag="CDO52_RS26055"
                     /old_locus_tag="CDO52_26040"
     CDS             complement(5748..6761)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618485.1"
                     /locus_tag="CDO52_RS26055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26040"
                     /product="asparaginase"
                     /protein_id="WP_017618485.1"
                     /transl_table=11
                     /translation="MQNQVPRRRVAVYGMGGTIAMAGVGGVVPSLSAAQLLDAVPGLAD
                     TGIDIEVNDFRRLPGASLGFADLTALAVDIDKRLASGDVDGIVVTQGTDTIEETSYLLD
                     LFHTAPQPVVVTGAMRNPTLAGADGPANLLAAVQTAAHPGSRDHGVLVVLADEIHAARH
                     VRKTHATSGHTFQSPNTGPLGHLVEGNPHFLSRLPAARATLDLTALHTDPRVALVTVVF
                     GDDGALVHDLAAWADGLVVAAFGVGHVPQGLVPVLSELAEHIPVVLASRAGSGPGLSST
                     YGFPGSESDLLEQGLIRAGFLDPLKSRILLWSLLATGHDGGSIAEVFRRAGAYGQG"
     gene            complement(6799..8256)
                     /locus_tag="CDO52_RS26060"
                     /old_locus_tag="CDO52_26045"
     CDS             complement(6799..8256)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601114.1"
                     /locus_tag="CDO52_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26045"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_026125764.1"
                     /transl_table=11
                     /translation="MPQPLKALRPGHSIGAWFGAELRHWRLQRGMSQKELGQRVWISGS
                     MIGKIETAERACPSSLAYKLDEILDTGGVLSRAWPLLDAHQRQAVSLAPEAVSGPTAVT
                     GPNVSLHGAAEPGGEGYLKTASGRFFAGARIEVQISRATRREDKIRIEEPPAAVTPVQA
                     QLLVGIHDDADGPAMVAIDARRKRRRLRQAPGTADISIPGAYVLDDLTTGLLWAASSLD
                     RALLFDDALISERKSELDNFEKFPRSSAGRDMAAELTAVSQLWMGSDFCARYILRQSSR
                     LTSTPDFWTRERTGEEASTWLLFAHKYSYLKALSERFPTGATRSFCIPELLVGSSPQAE
                     RFLIVLAAALMESFGIRIQVCSDPEYSTVEGFVLDPYRWAIIASWLGTDGIWHVDTTDS
                     MATVREYTDITAYASAHSVIDAPTPHERLRAFADYLNVEWSWLVRRCAELSTYGIAGLL
                     VPSSRLLSTTGIDRACRFLGKAALVKR"
     misc_feature    complement(7264..7266)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8471..9700
                     /gene="fxlM"
                     /locus_tag="CDO52_RS26065"
                     /old_locus_tag="CDO52_26050"
     CDS             8471..9700
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618483.1"
                     /locus_tag="CDO52_RS26065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26050"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_017618483.1"
                     /sec_met_domain="PCMT (E-value: 3.1e-46, bitscore: 156.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSENATIDPGRAEELRDQAVTQLVTDGTIVSQRVEAAMRAVPRER
                     FAPEAALEDVYSPYGAVITKRDEHRVAVSSVSAAQIQAMMLEQADLRPGHRVLEIGSGG
                     YNAALLAEIVGPGGAVTTIDIDPEVTERATRLLKENGYERVRVVRADAAQGVPEHAPYD
                     RILVTAGAWDIPPAWMDQLAAGGRLVVPLRMRNLTRSISFLKSGDHLTSTSARICGFVP
                     MQGAEEHRETLVLVNGTEEIALRFDDEVPADPHQLDNAILHPRVETWTGVTVGLQEVID
                     TLQLYLATHLPGFCIMAVDPNLDTGLVSPNNPRFSLAAVDDDTFAYLVTRRTPEEQSVE
                     YGIHAYGPHGAAFADAVSEHVRTWAREQRGGPGPRIDVYPVSADVAADLVITKMHTRVT
                     FTWPPATAAG"
     misc_feature    complement(9726..9741)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.31"
                     /tool="antismash"
     gene            9739..9903
                     /locus_tag="CDO52_RS26070"
                     /old_locus_tag="CDO52_26055"
     CDS             9739..9903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618482.1"
                     /locus_tag="CDO52_RS26070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26055"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_017618482.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.4e-16, bitscore:
                     57.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATSTPIDDEFALNVEVVVSTHPNGKLMCNTGDGCGNTCQQGASA
                     CNSFVGDPA"
     misc_feature    complement(9767..9782)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.25"
                     /tool="antismash"
     gene            10001..13054
                     /locus_tag="CDO52_RS26075"
                     /old_locus_tag="CDO52_26060"
     CDS             10001..13054
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618481.1"
                     /locus_tag="CDO52_RS26075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26060"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_094932769.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.7e-199,
                     bitscore: 660.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.1e-19,
                     bitscore: 66.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-11, bitscore:
                     42.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRSPYGYRWSGAAQLRASTTPHDLTVPHDPFDDASITPGREWL
                     ASVWEREEVRDALATVNPALCDHITTTLSRQDATPRRVRKTVLSLVAYLLRWQRPTPLA
                     TFAGVASLSIGDHPDAVRGTDHRIVARPDSDWLSDVIDRLHGCRALLERLRVVTDNTGH
                     VRGERFVTSGHSADGQTHLAAPEEVSISHSPPVAAALDAARTPVPYAQLRDLLAQRFPK
                     ADPARIMAMLDDLIAHRVLLTSLWAPMTRIDALGHVCEELAAANAQDIDEIADVVERLE
                     AIHRQLIRPTPTTLRERTAPVIDQMHTLTGIAPTPLTVDTIVDCQVRLPHHVVRAAEEA
                     ADVLTRLSSHPFGAPPWRDYHARFRERYGPGALVPVLDLVSDSGLGLPAGYLGSGRGRT
                     PRPLTDRDTALLALVQRAMAKGSDEIVLTEPLIDELAPEDDVLTVPRVELCGEIHAATL
                     HALAEGDFSLVVTAAPRPTSSMAGRFAHLLPDDDQQRLAASYHSPQPDTLVAQLSFPPR
                     KRRNANIARTTRLLPWAIPLAEHHSTGPDVIPLSDLAVTADARHFHLLRISTGQRVEAH
                     VTHALEPATHTPPLARFLAEITHSRCAAYGPFDFGAAAHLPYLPRVRYNTTILSAARWL
                     LDADNLPRATAPTPEWEESFTRWRRHWRVPDQVALVEHDRRLPLNLSHPVHRRLLRQRL
                     GTHDWVELREAAAPEQMGWLGHPHEALFTLTRPEPITPPPLIPLPVRPVSTQEAHLPGG
                     DVVHAQLYAHPQRFDEIITAYLPELGCLLHARDAWWFHRHCDMTRRDTDQYLAFYLRVP
                     PALSYGQAVETVHTWAQDLRRHRLLSRLALATYQPQTGRYGYGPALQAAEEVFAADSAA
                     AVAQIRAARRSHTAPQPLAAASMVDLVTSFTDHGLQWLSDDMPHTAGPVDQSLRRQALH
                     LAAPDGDRTALYALNSGDEVAAAWQTRAAALADYHKHLASERDPHTVLRSLLHLHHVRA
                     LGVSPNQETLTIRTARVVARSHTARTAR"
     aSDomain        10466..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CDO52_RS26075_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.70E-21"
                     /identifier="RREFam001.1"
                     /label="CDO52_RS26075"
                     /locus_tag="CDO52_RS26075"
                     /protein_end="248"
                     /protein_start="155"
                     /score="66.6"
                     /tool="antismash"
                     /translation="VVTDNTGHVRGERFVTSGHSADGQTHLAAPEEVSISHSPPVAAAL
                     DAARTPVPYAQLRDLLAQRFPKADPARIMAMLDDLIAHRVLLTSLWAP"
     gene            13051..14283
                     /locus_tag="CDO52_RS26080"
                     /old_locus_tag="CDO52_26065"
     CDS             13051..14283
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618480.1"
                     /locus_tag="CDO52_RS26080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26065"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_051060717.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-46, bitscore:
                     157.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNASSIPATDPAAVLDRLVQRLSAPHPPNAPGEGQSLAQGAAGTA
                     LLHIERAHTRQGTWDQAHRWITAATTGQVSAADTTGLFLGAPAIAFMLHAAAAGTSRYA
                     DALSTVDHHVSALAHRRVHNAMSRIHSGALATFGEYDVFYGLTGIGAYLLHRDPSSSAL
                     QRVLDYLVALTRPVMANGQTRPGWWVAHDPHRRTSPHFPGGHGNLGVAHGITGPLLLLS
                     QALRRGVTVDGHQEAITTISAHLDHWQQNTDPGPWWPEHLTAHDLATGTTHQPGPTRPS
                     WCYGTPGIARAGQLAALAIGDTHRQRFFECALDRCLSDPVQVERLTDASLCHGWAGLYQ
                     TVWRMARDATFPTLADHLPRLAAQLLRHADPTNVTAPGLLEGQAGAALPLITSVEDREP
                     VSGWDACLLID"
     gene            14316..15314
                     /locus_tag="CDO52_RS26085"
                     /old_locus_tag="CDO52_26070"
     CDS             14316..15314
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618479.1"
                     /locus_tag="CDO52_RS26085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26070"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_017618479.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-46, bitscore:
                     157.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERAVLQVLGGNPLPDVAAHLRMDPTELDTAVGVFRCGGRDALCQ
                     RASARWWQVYVEFTEWETAESYAVDHLAPLLRRWEAEQDITGWWFIRKYPCWRLRLRPR
                     GPQSPARIRAALDDLVNAGRIRRWWTGIYEPETAAFGGHVGIAIAHNLFHADSRAVLDL
                     STRDHTTIGRRELSILLCTALMRGAGLEWYEQGDVWDRVRHERPTPPDVTPERLRPMVN
                     ALQTLLLADTAPDGLMFGPDGPLKFAATWATASDQAGRDLRAAVRNGTLERGLRRILSY
                     LVIFHWNRLGLSGRDQSALSWAARTAILDAPTPNHDGPGGNLPQAPPEAVG"
     gene            15910..17487
                     /locus_tag="CDO52_RS26090"
                     /old_locus_tag="CDO52_26075"
     CDS             15910..17487
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618478.1"
                     /locus_tag="CDO52_RS26090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26075"
                     /product="class I SAM-dependent DNA methyltransferase"
                     /protein_id="WP_017618478.1"
                     /transl_table=11
                     /translation="MAVTQQEIESRLWDAADELRVAMPEAQYSSVVFPLMFWKYLSDTW
                     EHHHQEFLAENEGLDDLLSAEEAREIEYRDYQSFEIPVIHPGTVRERRASWSSILATIT
                     QPGLGHRVRASLQAIETANPDKFSRLFGSMTWTSEEVLSGEVLAAVMQAMDRTPKMHEG
                     NMSYDVLGGAYEYLLKRFSDGSGTRAGQFFTPREVVELIVEVLDPKGFESVYDPTCGSG
                     GMLIASANLLKARGGRGYTLRLHGQEAVPDTAGVARMNLFMHNLTQFQIEIGDTLKDPR
                     FNKPDGSLAKFDVIVANPPYSLKWNPWTNDPRALGGVAPQSSADWAFVQHMIASMGPKK
                     GRAGVVLPHGVLFRGGQEAAIRQRVLDDDLLEAVIGLPANLFYSTSIPTCILVFRAPGT
                     KAEERRKGVLFIDASKRFTKSKNRNVLTEADIADVVTAYHSKFDSEGNPVDPDGDGGIA
                     ARFVPAAEIVANGYDLNIGRYIKQAAVEQEDLGTLIDAYNIARAERQKSEQRMLAVLAD
                     AGIEGFDE"
     gene            17480..18646
                     /locus_tag="CDO52_RS26095"
                     /old_locus_tag="CDO52_26080"
     CDS             17480..18646
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013579.5"
                     /locus_tag="CDO52_RS26095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26080"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_017618477.1"
                     /transl_table=11
                     /translation="MSDWKRTTLGEVMTQVSRAVRVEDLTEARYAGVRWHAGGVYERET
                     VPAEKIKGKTLYRIKHDDIVYNRMWATKASFGVVKNDADGCFVTNDFPVFKVNPEAILP
                     EYVEAIFHTASFQSEASSRAVGTTERRRLHVRDFVNISVMLPSLPTQERIVEIIGAVDD
                     QIAALEAEAEAVVRVRTGLVRRSADTGQVPIGSLGVVSQGKGLPKEFQGKRTGEVSWYK
                     IADMAGPGNEFGYTLADTRLTPSEVAEIGGVVVEAGAVTFPRVGAAVLTEKKRIVEVPG
                     ALDENHLVITPGEGTNSEYLLAVMENFALSSLVRPGAVPSLNMGLIRSTEVPWSWTENQ
                     SLGTALGGLRAESRALAAEAARLRTARAALLSGLLDRSIDIESAEPEV"
     gene            18650..21727
                     /locus_tag="CDO52_RS26100"
                     /old_locus_tag="CDO52_26085"
     CDS             18650..21727
                     /EC_number="3.1.21.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009035 - type I site-specific
                     deoxyribonuclease activity [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623406.1"
                     /locus_tag="CDO52_RS26100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_26085"
                     /product="type I restriction endonuclease subunit R"
                     /protein_id="WP_017618476.1"
                     /transl_table=11
                     /translation="MAKGIREREFQNLMIQWSLPMGWEFTAGRSLARETTQTVVAGQLR
                     DAIVRLNPGVIDGFDVDAVVEEVVATVNVVEGGLVRANEQVLHLLRGRKEFRDADGVWH
                     TLKVIDFEHPTANTLVVSDEVTITVPGKTSRRFDLVYWVNGLPLVVVEVKSPTAKSAWA
                     DAAREINDVYATEYPWFFTPNVFAVASDGLNLRFGAAGAPTTLWHPFRSTADDENLSGQ
                     ADVQRSVELLMSPATILDMLANFVLFDTSGGGADNKYLSRYPQMEAAHLIHKRVLEGGA
                     KGLIWHHQGSGKTLLMVFTASLLLTDPRTESPTIILLSDRLQLVRQTSGVFTSAMGDAY
                     FHQPATGRELRSLLADDVRGVISTTVHKFADAGKNLSTRGNIIVLVDEAHRTQSTRSKS
                     LAGQMRAALPNAKFFGMTGTPIRNLATDTFALFGEQTDPDRVLHRYSVSRSLLDGATVP
                     VMLDPHPVSFEMNDQALQAEFDQFADDFDLDDPDREALSRKFGRLTSVFASPDRIHAVC
                     QHIVDHYLSGAYRNGLKAQVVAYNRELAVAYTDKINELLAGFEASQVLDEVGKHDRITA
                     EVNISVSDSKDENPAMRPFQLSEAEEEEQKRRFLTPDDPLCFLVVTAKLMTGFDAPNEG
                     GLYLDKPLKAHTLFQTITRPNRPWVSPTGFVKTSGVVVDYIGLAEEVQRAVADPTSKGA
                     GKGGGFVTDLTELVAEFRTTFARIEDLLADVDGLDLTVHGYESVRAINVFLDANPGAAE
                     AFAKDYRLLARLYPLINTDKRIAKYRDGIGLFGSVYTTLFKKSSEEERKERLSELGPMV
                     LEIINAHVHSFSVVASQRESLVLDARGIALLKELMSLVRPKPGKDDSDDKTPPSAAEIL
                     DHIKAALEKGVEPESAKYTALAERIKLLRDRIIQNAQDALEFLSEALRVARAIVDAEKH
                     PDEAVVVLDDDHVGVLSRIIHDHAPSGLTVTERNLAEEIDQVVTRTLARSWDNAEARKR
                     GVRRATAAVFRRYRLKPVGEPYDSTVAYIEAHYLVD"
     gene            22238..22462
                     /locus_tag="CDO52_RS28980"
     CDS             22238..22462
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623408.1"
                     /locus_tag="CDO52_RS28980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_232524331.1"
                     /transl_table=11
                     /translation="MFGAVDARVSVVSLPGRITVWVRGGTFTWRDADGRHQTHAWTDPQ
                     GEPNQAVKPARAANSTSARRCLYVPQEGE"
     misc_feature    complement(22494..22508)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            23264..24625
                     /locus_tag="CDO52_RS27885"
     CDS             23264..24625
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_152471597.1"
                     /transl_table=11
                     /translation="MGDPRKIFLFLGTFSQEGLRSKLNVTDVWYVTKRMESSPENWEKI
                     AKILENPNLVGVLGKFGRGAYLRMGSDEHLEVANGMLENLSKVPHIIFIHEDIINGDAA
                     RNYVEPLPVADAKGELYRTSFDACMSQIPEEKTIITNDLLKKHEIQVASYKKNSELYVL
                     ADSFIEDLENNLLFRIYVPKGRLYSNEMSRLLDLFREWLTTVKKEKIRQDGYKTSRGQV
                     FEFFSERNLGKEEVAEEIREFGRFLDLCDYPDEAALVLQGIGVEKSGATELVGRYAKEV
                     RRLRIDIKQEREQRVMQIRHRMESEIVDEADRPEIHWRAVSNLVASMIPEVPGDLTNLM
                     TRYAIDENSERTPIQINQQIIGRACGEVSQNVAGTQHFGPDAQALIEMIRNHGGAEEAE
                     LVASVHEVSDEEARMSDRLTAKHKIKRFLLRARDNVETTAYSLAQSYIESQMGL"
ORIGIN
        1 ctcgatctgg atctgttcgg cgacccgcac gtcgacgtcc ttggcggcgt cgcgggggcg
       61 gacctcgacg gtcgtgtcgg agcggtcgcc ggcgttgatc tggacggcgc cgacgaggag
      121 gtcgatctcg gcggtaatgg gttcgggtgt gtcgaaagtt ggcatggctg tctccaggtc
      181 atggcggtgg tgggcgtctc cgctggtggg agacgtagtg gaaatggggc gggggcggct
      241 agcggaccca gccggtgtag cctcgtccga cctggcggcc cgcgccccga tcgggccgtc
      301 gagcgccggt gtcgagcccg gcggcaactg cgcgcaccag ccaggcgttg accgacagcc
      361 cttcgcggcg ggcggcctcc tcgacctgag gcttgaggtg gacgggcagg cgcagggtga
      421 cccgcgacgt gccgccgtcc tcggcgtcat gcggctgcga ctccgcaacg ggcccggcct
      481 ccgccgcggc ctcgcccgac gagggccgcg gcgacgcgag gcccccgtcg gagggaccgt
      541 cgaccggttc gtccgtcggc ggtggcgtca caatgaagtc agtctgaccc cctcgcagcc
      601 gaacctcgac cgaaccagga gcgaaatcgc gggtgatctc gtcggcggcc tcggaaagcg
      661 catccagtaa ggccagtcgc gcagccggct ccagcgccgc cgccagccgc tcagcgaccg
      721 cccgagcatc ctcgttgcca gcttcggcgg ccaccacgag ctggcggcgg aggttgtcca
      781 catacggcat cagatccatg acttcactat gacgtcatca tgacgtcacg tcaagccgaa
      841 tttgatgcac attgacgcca ccccgcgtct tccgatgaat cacttcaggc tgcccggaga
      901 ccccgatgac gggttcgccc tgtagttctg gcgtactgtg agggtcgtcg ccggacatcg
      961 gctaacgctg aagccctctg gcctgaccag gtgctttcct aacccagaag aagctgccac
     1021 cccacatgtc acccaccgtg tagccgcaag gaaacagggc gtcggggagg atgtgctggt
     1081 tgacgccggt gatccaggct cggccctcga tcaaggggat cacggcgtcg cgtccggcgg
     1141 accggacccg ctcgtgcagt atgcccttga acgtgatgcc gaggacgccc tggcgagatt
     1201 actcccggtg ggtttccccg acccgcccgc cgaacccgtc gcgcccacgt ccgagcaccg
     1261 gccccggcga ggtcatggac gaggtgcctg gcgcgttgcc ggtggctccg gtgatgacgt
     1321 acgtgctcac ctttctctcc ctgttcggga gcgcctacct atgcgcctgc tgtcgctcgc
     1381 ccgcaggatc cgcgtcggac gccgtgtcca gggccgtcga cgggatttcc tgcaggcggc
     1441 ccggcagcaa cgggctggcg gccaggatga ccacggccac cgccaagagg aaccagttga
     1501 cctgctggaa gccgccgatc ccgccggata ccccgcccgc tcccgcggcc gcgaggatca
     1561 gggcggcgca ggcgacgccg agtgcgccgc cgagctggtt gaggttgtag agcacggagc
     1621 tgccctgcgg caccttctcg gcgggcagcg tccggtacag ggatcccatg gtcggcgcac
     1681 ccacagcgcc cagaccgaat ccgatgacca atgccgccag ggccgaccac gcctccccgc
     1741 tctcggctcc gatgcgggtg agagcgaacg cgcccgccgc cgccagcacc gcgccgccct
     1801 gtaccaggct gcgcgccccc agcctgtcgc tgagcctccc ggcgatgggc atcgcgaaag
     1861 ccgatcccag ccccagcggg gccaccagca gcccggcgcc gccagcgccg tgatcgtgga
     1921 tgatctggta gtagaggggc agcgcgaaga gccctgcata ggtgcccagg cccacgagcc
     1981 cctgcacggt cacgctcgcg gcgaagctgc ggctggtgaa gaggcgcacg tcgatcagcg
     2041 gctcggtcgt ccggacacgc agcgcgtgga ccacgtaccc gaaaagcagg gcgagtccga
     2101 tggagagcgg ggccagcacc gcgggcgcag cgaactccgc gtgctcgcct gcctgggtga
     2161 gcgcgaggac ggtcgcggcg aatccgggcg ccagcagcag gaagccaacg atgtcgagcg
     2221 gcgtgcgcgc gtcctgctcc ccgggcgggt cggtcgggat cacgcgcagc gcgagcatga
     2281 aggcgacgat gccgatgggc aggttgatgt agaacatcga gcgccagccc atggagtcga
     2341 gcaggaggcc gccaagcact gggccgagca ccggacccag tgacagcacg acgcccatca
     2401 tgcccataac ccgtcccgca cggctcgggc cggcggcccg agccaggatc accagcacca
     2461 gcgggtcgag aatgcctgcg ccggcgcctt ggaccacccg aaagagaacg aggctctcca
     2521 cgctccagga gagcgccgag gcgagcgagg ccgccacgaa gaggacgaga ccaaacagcc
     2581 acagccgctt cacgccgaat ctgcggacgg cccagctggt gatggggatg gtgacggtga
     2641 gcgcgagcag atagccggtc gaggcccaac tgatcacgct gagcgagctg ccgaacgctt
     2701 gggagagcgt gtcggctgcg acggtgacca tggtgctgtc gaggatcccc atgatcccgc
     2761 ccagcagagt cacaccgatc agccgtagga gcgcggtgtc caggcggtcg tctctgactt
     2821 gagtcatgcg gctcccattc cgctaccagt tcgtgcaatt tattgaacca atcggttcaa
     2881 gttaactaac ggaactaact cggggcaacc gaatttggaa atatcttgaa ccggatggtt
     2941 cagtctgagg agtagagcgg tacgatgccg ctgtgaacgc agccaagacc tcagaaacgg
     3001 ggagccgcag cagcccccgc gggcgcatcg acaaacggca ggcgatcctg gacgccgcgt
     3061 tccgagtctt tgcccgggac gggtacggac agtcctgcgt gcgcgagatc gcagatgagg
     3121 ccagggtggc caagcccacc gtttacaacc acctcggcga caaggagact ctcttccacg
     3181 aggccttgca ggcggccgtg ggccgaacag tcgatcgatc gctggccgcg ctcgacaagc
     3241 tgcgcggatc tgagggcgac ctgcgtgcca cgctggaaga ggtagggcac ctactgctgc
     3301 agaaccactg ctgcgccgaa tcgcaggcgc tacgccgact gctcaacgcc gaagccgcac
     3361 gcttccccga cctgttgaac gagatccaga gtgcgggagc ccagcgcatc cagaacgccc
     3421 tcgccgaccg cctggcccgg ctcgcactcg ccaagcggct gaacatcgcc gaccccgaac
     3481 aggcgagcga gcagttcctc gcgctactca ccggtcccat ggagctgcgt tcccggctcg
     3541 ggacccgaca ggtccccgac accgagctgc gttccgtggc cggagccgcc cgcgacacct
     3601 tcctgctcgc ctacgcgccc cagggcgagg ccgactgaac cggccgggag aacgcagggc
     3661 gagaagtgac gagcagcggc cggtgcgatc cgcatgtttt caagggagga cggtagtcat
     3721 ggccactgca ctgattgctg atccggacaa gggcctcggc ctagaaaccg cccgaaggct
     3781 gatcgccgct ggccacaccg tcttcctggg ttcccgagac ccggaacagg accggtcggc
     3841 agcggaggag acaggcgggc gcgccgttca actcgatgtg accagcgacg cctcagtccg
     3901 ggatacggcg aacacgatcg cggaccagac cggacacctc gacgtcctgg tcaacaacgc
     3961 cggaatcacc ggaccgctcc agccacacac gcgggacaca catcccatcg ggattgggct
     4021 tcgtcgattc gtttccgaac taagccgagc ttccgcacat gcgtgctaga agcccccaaa
     4081 gacagcgctt atgtgaagag agtaaccatg cagcttctga tgacgtgtgc ccggtgtaga
     4141 aagcgcatgt attcttggcg gcgtctacct tgtgcagcgc tgcacaaatg cgctggccag
     4201 cgaggacata ggcaaagccc cgacacggct tgggaggcag cgccggggct ttaccatctg
     4261 cggccgaccc cccctgcggg gtcggcctag ctcttggcca cgtcgatcaa gagcctgacc
     4321 agcacttcaa ggaatcgcca gaagtctggc agcttccaaa actggtcact gggcttcggc
     4381 tccatagccc tccttctgcc atacggttcc tagtgcaacc ggctgtcggt gaccgccagc
     4441 gctagcgacc cgtcggtcac ctgcggcagg gaggcgtcaa gcttccgcca aagccaacgt
     4501 atcgccactg gggctggccg aggactcaac cttttcgcga aactgcacgt cagggccaat
     4561 aatggccaat ttcgcagcgg ctcacgcgtt cctgaccagc acctttagga acccctttct
     4621 aacagggttg cagcccaccc ccacagaagt gttataagtc acattctaga gagctgtgct
     4681 catgccgccg actgtgctgg cacactctcg tgcgaccttg gtggcgaagg agtaggtggg
     4741 aggaggaaac cggatcgctt gtacatctac cgtttaatta gcttcgacca tgcgttcgca
     4801 cctgccgtgc caccgttgtg gtcacggcag gtcacggcca cgacgtcgcg gccctggccg
     4861 aggccacgag tgaaggcatg ccgttcgaag aggtcatcct cactaccggt ggtggtccac
     4921 tccttgagaa tcctaatgtc gtccggggcg agtgacagca tccgagcgaa gccacgaatc
     4981 gtgtgcggtg agccgggcca tcccggggca caccgcagtc aggtcggcgc ccctccggcg
     5041 ctcctcggcg gtgagccttg cgagctcgac caagagcggt ctggtggtgt cataccgcct
     5101 cagcaacccc tttgaccggc agcgttgcta cgacgacatg acgccagcct gcaacgtggt
     5161 tgatgccgtt atcggctagg acagagggaa gacaggtgtt gaggcgcgtg ttttagcgtc
     5221 cccatttatt cttcgcgatc gaagtgaagg agaggcacgt catagagcgc agggttcggt
     5281 atccgccgca tttgtggcga ggtgatctcg acgagaacca tctcggtgag gaactggacc
     5341 tcggcggcca ggaggtggct ggtgtgtccg gtagcgctgt gttccttgag gccgacggag
     5401 acgtggacgt ggggcgagat cgtgtcattg gcctcgtcgt gggcgatggt gccgccgccc
     5461 acggcctcga cgttggtcag gtggaccttt gaccagacgg gcgctagtgg atcggtgagc
     5521 tgctcacagg taccgacgat gtcgacgtgc gcgaagcccg cgatgaacat cgggatgtag
     5581 ccctggcgga cgttgttggt acggcagaac gcgttcagag tctcgaagaa gttctcgccg
     5641 tggtcgaaga cgacaccgaa ggtgcggccc ggggtcagtt catggctgcg cacgtcgttc
     5701 ctcgttcctt tccgtcgcgg agcagagggg agatggtggt ggccaggtca gccctggccg
     5761 taggctcctg ccctcctgaa cacctcggcg atcgatccac cgtcatgacc agtggccagg
     5821 agtgaccaga gcaggatgcg cgactttagt gggtccagga acccggcgcg gatcagcccc
     5881 tgttccagca ggtcgctttc ggagccgggg aacccgtagg tggaggacag gccggggccc
     5941 gagccggcac gcgaggcaag gacgaccggg atgtgttcgg ctagctcgct gagaaccgga
     6001 acgaggccct gcgggacgtg gccgacgccg aatgccgcga cgaccaggcc gtccgcccac
     6061 gcggcgagat cgtgaacgag ggcgccgtcg tcgccgaaca caacggtcac cagggccacg
     6121 cggggatcgg tgtgcagtgc agtgaggtcg agggtggcgc gggcggcggg cagacggctg
     6181 aggaagtgcg ggttgccttc gacgaggtgg cccaaggggc cggtattggg ggactgaaag
     6241 gtgtggccgc tggtggcgtg ggtcttgcgg acgtggcgcg cggcgtggat ttcgtcggcg
     6301 agcacgacga gcaccccgtg gtcccgcgaa cccgggtggg cggcggtctg cacggccgcg
     6361 agcaggttcg ctgggccatc ggctccggcc agggtggggt tgcgcatggc tcctgtgacg
     6421 acgaccggct gcggcgcagt gtggaacagg tcgagcaggt agctggtctc ctcgatggtg
     6481 tcggtgccct gggtgaccac gatgccatcg acgtcacctg aggccagtcg cttgtcgatg
     6541 tcgactgcaa gagcggtcag atctgcgaag cccagcgatg caccgggcag gcgccgaaag
     6601 tcgttgacct cgatgtcgat accggtgtca gcgagcccgg gaacagcgtc gaggagctgg
     6661 gcggcagaca acgaggggac gacgccgccc acgccagcca tcgcgatggt gccgcccatg
     6721 ccgtacaccg ctacccggcg acgaggaacc tggttctgca tttccgcttc cttccgcgcc
     6781 gattcctgtg cgggcagcct aacgctttac caaggccgct tttccgagga atctgcaggc
     6841 gcggtcgatc ccggtggtgc tgagaagtcg gcttgatggg acgagcaatc ccgcgattcc
     6901 ataggtgctg agctcggcgc atcggcgcac caaccaagac cattccacgt tcagatagtc
     6961 cgcgaacgca cgcagccgct cgtggggcgt gggagcgtcg atgactgagt gtgcgctggc
     7021 gtaggcggtg atgtcggtgt actcgcgcac cgtcgccatg ctgtcggttg tgtccacatg
     7081 ccagatgccg tccgtgccca gccaactggc gatgatcgcc caacggtagg gatcgagcac
     7141 gaacccctca accgtgctgt actcgggatc gctgcatacc tgaatccgga tcccgaagga
     7201 ctccatcaat gctgccgcaa ggacgatcag gaaccgttcg gcctggggtg aagatccgac
     7261 gagtaactcg gggatgcaaa atgagcgcgt cgctccggtc gggaacctct cggacagggc
     7321 cttgaggtag ctgtacttgt gggcgaacaa cagccacgtg ctggcctcct cgccggtgcg
     7381 ctcacgcgtc cagaagtcag gggtggaggt gaggcgggag gattggcgga ggatgtatcg
     7441 ggcgcagaag tccgagccca tccacaactg ggagaccgca gtcagctccg cggccatgtc
     7501 ccgtccggcc gaggaacgag gaaacttctc gaagttgtcg agttcggact tgcgctcgga
     7561 gatcaacgca tcatcgaaca gaagcgctct gtccaaggag ctcgccgccc acagcagacc
     7621 tgtggtgagg tcatcgagga catacgcccc gggaatgctg atgtcggccg tgccgggtgc
     7681 ttgtcggagt cggcggcgtt tcctgcgggc atcgatcgcg accatcgcgg ggccgtccgc
     7741 atcgtcgtgg attccaacca ggagttgggc ttggacgggc gtcacggcag cgggcggttc
     7801 ctcaatgcgg atcttgtcct cccgccgagt cgctcgactg atctgcactt cgatccgtgc
     7861 accagcgaag aagcggcccg aggcagtttt cagatagccc tccccgccgg gttcggccgc
     7921 accgtgcagt gacacgttcg gcccggtcac tgccgtgggc cccgagacag cttcgggagc
     7981 caggctcaca gcttggcgct ggtgggcgtc caaaagtggc caggcgcggc tgagaacgcc
     8041 gccggtgtcg aggatttcgt cgagtttgta ggcgaggctg ctcgggcaag cgcgctcagc
     8101 ggtttcgatc ttgccgatca tgctgccgct gatccatacc cgttggccga gttccttttg
     8161 ggacatgccg cgttgcagtc gccagtgacg cagctcggca ccgaaccaag caccgatgga
     8221 atgacctggt cgtagcgctt tgagtggctg aggcaccggg gcacctccga tgagagttga
     8281 tgcggacagt tcctgctgtc cgcatcagca tctcgactcg tgcccctgag cgccaccaaa
     8341 ttgggaactg cggtcagccg cacgttcggg caggacgtga gaagcattca tagatgtgcg
     8401 gttgcccggg ttctagcagc gcggcaagcc tgtggcgtat cggccatcga tcccaacgag
     8461 gagcacccca atgagcgaaa acgcgaccat cgaccccggc cgcgccgaag agttgcggga
     8521 ccaggccgtc acccagctcg tcaccgacgg cacgattgtc tctcaacggg tcgaggccgc
     8581 catgcgcgcg gttccccgtg aacgattcgc gcccgaagcc gccttggagg acgtctacag
     8641 cccctatggc gcggtgatca ccaagcggga tgagcacagg gtcgcggtca gctcggtgtc
     8701 ggccgcccag atccaggcga tgatgctgga gcaggctgac ctgcgtccgg ggcaccgggt
     8761 gctggagatc ggatcaggcg ggtacaacgc ggcgctgctc gccgagatcg tcggcccggg
     8821 cggtgcggtc accacaatcg acatcgaccc cgaggtcaca gagcgcgcga ctcggctcct
     8881 caaggagaac ggctatgagc gggtgcgcgt ggtgcgcgcc gatgccgccc agggggttcc
     8941 cgagcacgcc ccttacgacc gaatcctggt gactgcaggg gcctgggaca ttccaccggc
     9001 ctggatggac cagctcgccg ctggtgggcg gctcgtggtg cccctgcgaa tgcgcaacct
     9061 cacccgatca atcagcttcc tcaagtccgg cgatcacctg accagcacct cggcccgcat
     9121 ctgcgggttc gtgcccatgc agggcgccga ggagcaccgc gagacgctgg tgctggtcaa
     9181 cggaactgag gagatcgctc tgcgtttcga tgacgaggtg cccgctgacc cccaccagct
     9241 ggacaacgcg atactccacc cccgtgtcga gacctggacc ggggtcaccg ttggcctgca
     9301 agaggtcatc gacacgctcc agctgtacct ggccacacac ttgcccggat tctgcatcat
     9361 ggccgtcgac cccaacctgg acaccgggct ggtctcaccg aacaaccccc gcttctccct
     9421 ggccgccgtc gacgacgaca ccttcgccta cctcgtcacc cgccgcaccc ctgaggaaca
     9481 gtcggtcgaa tatggcatcc acgcctacgg ccctcacggg gcggcgttcg ccgacgcggt
     9541 gtcggaacac gtgcgcacct gggcacgcga acagcgcggc ggccccggac cgcgtatcga
     9601 cgtctatccc gtctccgctg atgtagcggc ggacctggtc atcaccaaga tgcacacccg
     9661 cgtcacattc acctggcccc cggccaccgc tgcgggctag gccatctcac accaccacag
     9721 gtaaggagag tgattcccat ggctacctcc acccctattg acgacgagtt cgctctcaac
     9781 gtcgaggtcg tagtgtccac acaccccaac ggcaagctca tgtgcaacac cggtgacggg
     9841 tgcggcaata cctgccagca gggggcttcg gcctgcaact ccttcgtggg cgaccccgcc
     9901 tgaggcgccc gtgccccagg ggtgggtcgg aaccccgctt cggacccacc cccgcacatc
     9961 ccgccccacg aatggagttg aggacgaaac gagggcaacc atgtcgaagc gatccccgta
    10021 cggctaccgc tggagcggcg cagcacagct acgcgccagc accaccccac acgacctcac
    10081 cgtcccccac gaccccttcg acgacgcctc catcacaccg gggcgtgagt ggctggccag
    10141 cgtctgggag cgcgaggagg tccgcgatgc cctggccacg gtcaaccccg ccttgtgcga
    10201 ccacatcacc accaccctgt cgaggcagga cgccaccccg cgccgcgtgc gcaagacggt
    10261 gctctcgctg gtcgcctacc tgctccgctg gcagcgcccg accccgctgg cgacattcgc
    10321 gggagtcgcc tccctctcca tcggggacca tcccgatgct gtgcggggca ccgaccatcg
    10381 catcgtcgcg cgccccgact ccgactggct gtccgatgtc atcgaccgcc tgcacggatg
    10441 ccgagccctg ctggagcggc tgagagtggt gacggacaac accggccacg tccgcgggga
    10501 acggttcgtg acgtccgggc actcagccga cggccagaca cacctggccg cacccgaaga
    10561 ggtttccatc agtcacagcc cgccggtggc cgctgctctg gacgccgcgc gcacccccgt
    10621 gccctacgcc cagttgcgcg acctgctcgc ccagcgcttc ccgaaggcgg accccgcgcg
    10681 catcatggcg atgctcgatg acctcatcgc ccaccgcgtg ctgctcacca gcctgtgggc
    10741 accgatgacc cgcatagacg cactggggca tgtgtgtgag gaactcgcgg cagccaatgc
    10801 ccaggacatc gacgagatcg ccgacgtggt ggagcggctg gaagcgatcc accggcagct
    10861 catccgcccg accccgacca ccctgcggga gcgtacggcc cctgtcatcg accagatgca
    10921 cacgctcacg ggcatcgccc ccacgccgct caccgtagac acgatcgtgg actgccaagt
    10981 gcgcctgccc caccacgtgg tgcgcgccgc ggaggaggcc gccgatgtgc tcacccgcct
    11041 gagctcccac cccttcggcg caccgccctg gcgcgactac cacgcccgtt tccgcgaacg
    11101 gtacggcccc ggtgcgctcg ttcccgtact cgacctggtc agtgacagcg gcctgggcct
    11161 gcctgccgga tacctgggct ccgggcgcgg acgcacgccg cggcccctga ccgaccgcga
    11221 caccgccctg ctcgcccttg tccagagagc tatggccaag ggcagcgatg agatcgtcct
    11281 caccgagccc ctcatcgacg aactcgcccc cgaggacgac gtcctgaccg tgcctcgcgt
    11341 cgagctatgc ggagagatcc atgccgccac actccatgcg ctcgcagagg gggacttcag
    11401 cctcgtcgtg accgcagcac cgcgcccgac cagcagcatg gccgggcgat tcgctcacct
    11461 gctgcccgac gacgaccagc aacgactcgc cgcctcctat cacagcccgc agcccgacac
    11521 gctggtcgcg cagctgtcgt ttccgccacg caagcgccga aacgccaaca tcgcccgcac
    11581 cacacgccta ctgccctggg ccatcccact ggccgaacac cactcgaccg gtcccgacgt
    11641 gatcccgctt tccgacctcg ccgtcaccgc cgatgcccgc cacttccact tgctgcggat
    11701 ctccaccggc cagcgcgttg aagcccacgt cacccacgcc ctggaacccg caacccacac
    11761 cccgcccctg gcccgcttcc tcgccgagat cacgcacagc cgttgcgccg cctatggccc
    11821 cttcgacttc ggcgccgccg cgcacctgcc ctacctaccc cgggtgcgct acaacaccac
    11881 gatcctttcc gccgctcggt ggctgctcga cgccgacaac cttcctcgcg ccaccgcgcc
    11941 cactcccgag tgggaggaga gcttcacccg atggcgtcga cactggcgtg tccccgacca
    12001 agtcgcgctg gtggagcacg atcggcggct tccgctgaac ctgtcacacc ccgttcaccg
    12061 ccgactgctg cgccagcggc tgggcaccca cgactgggtg gagctgcggg aggccgcagc
    12121 tccagagcag atgggctggc tcggtcatcc gcacgaggcg ctgttcaccc tgacacgccc
    12181 cgagcccatc accccgccgc ccctaatccc gctccccgta cgtccggtca gcacccagga
    12241 ggcccatctg cccgggggag acgtcgtgca tgcccagctt tatgcccacc cccagcgttt
    12301 cgacgagatc atcaccgcct atctgcccga gctggggtgc ctcctccacg cgcgcgacgc
    12361 gtggtggttc catcggcact gcgacatgac gcgccgggat acggatcagt acctggcctt
    12421 ctaccttcgc gttcctcccg ccctctccta cggacaagcc gtcgagaccg tgcacacctg
    12481 ggctcaagac ctgcgccgcc atcgcctgct gtctcgcctg gctctggcca cctaccagcc
    12541 gcagaccggg cgctatgggt acggcccggc gctacaggca gccgaggagg tgttcgccgc
    12601 cgactcagcc gccgccgttg cacagatccg cgcggcccgc cgctcgcaca ccgctcccca
    12661 gcccctggcg gcggccagca tggtcgacct cgtcacgtcc ttcaccgacc acggacttca
    12721 atggctgtcc gacgacatgc cccacactgc cggccccgtg gaccaatccc tccgccgcca
    12781 ggccctgcac ttggccgccc ccgatggcga ccgcaccgcc ctatacgccc tgaatagcgg
    12841 cgatgaggtg gccgccgcat ggcagacccg cgccgccgcc ctggccgact accacaagca
    12901 cttggcttcc gagcgagacc cgcacacggt cctgcggtcc ctgctccacc tccaccacgt
    12961 gcgcgcgctc ggcgtcagcc ccaaccagga gaccctcacc atccggaccg cacgcgttgt
    13021 cgctcgctcc cacaccgcgc ggacggcacg atgaacgcct cctccatacc agcgactgac
    13081 ccggccgccg tgctcgaccg cctcgtccaa cgcttgtccg ccccgcatcc cccgaacgca
    13141 ccgggcgagg ggcagtccct agcccaaggc gcagcgggaa ccgccctgct gcacatcgaa
    13201 cgcgctcaca cccggcaggg cacctgggac caggctcacc gctggatcac cgcagcgacc
    13261 accgggcagg tcagcgccgc cgacaccacc ggcctgttcc tgggtgcacc cgccatcgcc
    13321 ttcatgctgc acgccgcagc cgccggtacc tcccgctatg ccgacgccct gtccaccgtg
    13381 gaccaccacg tgtcggccct cgcccaccgg cgcgtccaca acgccatgag ccgtatccac
    13441 agcggcgcct tggccacctt cggcgagtac gacgtgttct acgggctcac cggaatcggc
    13501 gcctacctcc tgcaccgcga ccccagcagt agtgccctgc aacgcgtcct ggactacctg
    13561 gttgcgctca cccgccccgt gatggctaac ggtcagaccc ggcccggctg gtgggtcgcc
    13621 cacgaccccc atcgccgcac ttcacctcac ttccccggcg ggcacggcaa tctcggcgtc
    13681 gcccacggca tcaccggccc gttgctgctg ctcagccagg ccctgcggcg tggagtcacc
    13741 gtggacggcc accaggaggc catcaccacc atcagcgccc acctcgacca ctggcaacag
    13801 aacacagacc ccggcccctg gtggcccgag cacctcaccg cccacgatct ggccaccgga
    13861 accacccacc aacccggccc aacgcgcccc tcctggtgct acggcacccc cgggatcgcc
    13921 cgcgccggac aactcgccgc gctggccatc ggcgataccc accggcaacg cttcttcgaa
    13981 tgcgccctcg accgatgcct gtccgacccc gttcaggtgg agcgcctcac cgacgccagc
    14041 ctgtgtcacg gctgggccgg cctctaccag accgtgtggc gcatggctcg cgacgccacc
    14101 tttccgaccc tggccgacca ccttccccgc ctggctgccc agctgctccg ccacgccgat
    14161 cccacgaacg tcacggctcc gggactcttg gaaggccagg cgggcgctgc cctcccccta
    14221 atcacttccg tcgaagatcg cgaaccggtc tctggatggg acgcatgcct gctgatcgac
    14281 tgatccaccc gcttcaagcc ccaacagcag aggtcatgga gcgcgccgtc ctgcaggtcc
    14341 ttggtggaaa cccgctgccc gacgtggccg cgcacctgag gatggatccc acggagctag
    14401 acacagcagt gggggtgttc cgctgcggcg gacgcgacgc cctctgccag cgcgccagcg
    14461 cccgctggtg gcaggtctac gtcgaattca ccgaatggga gacggctgag tcctacgcag
    14521 tggaccatct tgctccgctc ctgcgacgtt gggaagccga gcaggacatc accggctggt
    14581 ggttcatccg caaatacccc tgctggagac tgcgcctgcg cccgcgcggc ccgcagtccc
    14641 cagcacggat ccgcgcggcc ctggacgacc tggtgaacgc cgggcggatc cgacggtggt
    14701 ggaccggcat ctacgaaccg gaaaccgccg cgttcggagg acatgtcggc atcgcgatcg
    14761 ctcacaacct cttccacgcc gacagcaggg cggtcctgga cctctccacg cgcgatcaca
    14821 ccacgattgg ccgccgtgaa ctgtccatcc tgctctgcac agcgctgatg cgcggcgctg
    14881 gcctcgaatg gtacgaacag ggcgacgtgt gggaccgcgt ccgccacgaa cgccccaccc
    14941 cgccggacgt cacccctgaa cggcttcgcc ctatggtcaa tgccctacag acactgctgc
    15001 tggccgatac cgcccccgat gggctcatgt tcggtccgga cggccctctg aaattcgctg
    15061 caacctgggc caccgcctcc gaccaggcgg gtcgggatct gagggcggcg gtccgtaacg
    15121 gcacactcga acggggtttg cgtcgcatct tgtcctacct agtgatcttc cactggaatc
    15181 gcctcggcct ctcagggcgg gaccagagcg cgctgtcctg ggctgcacgc accgcaattc
    15241 tggacgcgcc taccccaaac catgatggtc caggaggcaa cctcccacag gcaccgccgg
    15301 aagctgtcgg gtgatcctga ccaggcgtac cgtgctccca cgtaacaacg acgcggagcg
    15361 catccgtcca tccgcggccg ttccccaccg agtcggcagg cccggtgcac caccaagggt
    15421 gcacgccgga catgcgactg gcaatctgaa tacgcctggc tatgagacgc gcacccggga
    15481 aatcagtagg cgctgagcac caatagccct cttcggggga cgtgaccgag gcttcaaggg
    15541 gaccccagac aagcggtcaa tccggtagcc gtcggctgac gatcagcgca acgatacccc
    15601 ggcggcgccc aggaacatgg cgcagcctgc tgcccgggcc gccagcatgc ggttcgggca
    15661 gccctgcttc gcggaaaccg cgcctgacat tatcgggcgc atccctcttt ggagactaat
    15721 gcgaagtatc gcactcccct cacctgcaca cctccgtgat cgcctggact ttgtatcagt
    15781 ccggcgcgtg ttcaccaagc tggacacacc tgtcgtgtac atgccgggca cgccttaaat
    15841 tgggtgacta gcaggaacac cacgaccttc gggtcgcctc cctttgacga acaaggacac
    15901 ccccgactga tggcagtgac ccagcaggag atcgagagcc ggttgtggga cgccgccgac
    15961 gagctgcgcg tagcgatgcc cgaagcgcaa tactcctcgg tcgtcttccc gctgatgttc
    16021 tggaagtacc tgtcggacac ctgggagcat caccaccagg agttcctggc cgaaaacgag
    16081 ggcttggacg acctcctctc ggccgaggaa gcccgcgaga tcgagtaccg cgactaccag
    16141 tcgttcgaga tcccggtcat ccaccccggc accgtccggg agcgtcgcgc ctcttggtcg
    16201 tccatcctcg ccaccattac ccagcctggc ctcggccatc gggtccgcgc ctccctgcag
    16261 gcgatcgaga cggccaaccc tgacaagttc tcccgcctgt tcgggtccat gacctggacc
    16321 tccgaagagg tgctgtcggg ggaggtgctg gcggcggtca tgcaggcgat ggaccgcacc
    16381 ccgaagatgc acgagggcaa catgtcctac gacgtgctcg gtggggcgta cgagtacctg
    16441 ctgaagcggt tctccgacgg gtccggcacc cgcgccggcc agttcttcac cccgcgcgag
    16501 gtcgtcgagc tgatcgtcga ggtccttgac cccaagggct tcgagtcggt ctacgacccg
    16561 acctgtgggt cgggcggtat gctcatcgcc tccgcgaacc ttctgaaggc ccgcggtggg
    16621 cgtggttaca cgctcagatt gcacgggcag gaggccgtac cggacactgc gggtgtggca
    16681 cgcatgaatc tcttcatgca caatctcacc cagttccaga tcgagatcgg cgacaccctg
    16741 aaggacccgc gtttcaataa gccggacggg tccctcgcga agttcgatgt gatcgtcgct
    16801 aacccgccct acagtctgaa gtggaatccc tggaccaatg acccgcgcgc cctcggcggg
    16861 gtcgcaccgc agtcgtcggc ggactgggcg ttcgtccagc acatgatcgc cagcatgggc
    16921 ccgaagaagg gccgtgccgg cgtggtcctt ccccacggcg tcctcttccg cggcggccag
    16981 gaagcagcca tccgccagcg cgtcctggat gacgacctcc tcgaggccgt gatcggccta
    17041 ccagcgaacc tcttctattc gacctccatc ccgacctgca ttctcgtgtt ccgtgccccc
    17101 ggcaccaaag ccgaggagcg ccggaagggg gtactgttca tcgacgcctc caagcggttc
    17161 accaagagca agaaccggaa cgtcctgacc gaggcggaca tcgccgatgt ggtgactgcc
    17221 taccactcga agttcgattc cgagggcaac ccggtcgacc ccgacggcga cggcggaatc
    17281 gcggcgcgat tcgtccccgc cgcggagatc gtggcgaacg ggtacgacct caacatcggg
    17341 cggtacatca agcaggccgc cgtcgagcag gaagatctcg gcaccctgat tgacgcctac
    17401 aacatcgccc gagccgagcg ccagaagagc gagcagcgca tgctcgcggt cctcgccgat
    17461 gccggaatcg agggcttcga tgagtgactg gaagcggacc acccttgggg aggtgatgac
    17521 ccaggtttcc cgcgcagtcc gggtcgagga cctgaccgag gctcgatatg ccggggtgcg
    17581 ctggcatgcc ggaggagtat acgagcgtga gacggttccc gctgagaaga tcaagggcaa
    17641 gacgctctac cggatcaagc atgatgacat cgtgtacaac cggatgtggg cgaccaaagc
    17701 ctctttcggg gttgtcaaga acgacgctga cggctgcttt gtcaccaacg acttcccagt
    17761 gttcaaggtc aatcccgagg cgatcctccc ggaatatgtc gaggctatct tccacaccgc
    17821 gtcgttccag tctgaggcgt caagtcgagc ggtcggcacc acagagcgcc gacgcctcca
    17881 tgtacgggac ttcgtgaaca tctccgtcat gctgccgtcc ctaccgacac aggagcggat
    17941 cgtcgagatc atcggcgcgg tcgacgacca gatagccgca cttgaggctg aggccgaggc
    18001 cgtcgtcaga gtccgtaccg gcctggtccg aaggtctgcc gataccgggc aggtgcccat
    18061 cggaagcctg ggggttgtgt cgcaggggaa ggggctcccg aaggagttcc agggcaagcg
    18121 aacgggcgag gtttcttggt acaagattgc ggacatggcc ggcccgggga acgagttcgg
    18181 ctacaccctt gccgatacgc ggcttacccc ctcggaggtg gctgagattg gcggtgttgt
    18241 ggtcgaggct ggcgcggtga cattcccgag ggtgggggcg gcagttctca ctgagaagaa
    18301 gcggattgtg gaggtccccg gagcgctgga tgagaaccac cttgtcatca cgcccgggga
    18361 agggacgaac tcggagtacc tgctggcggt catggagaac ttcgcactct cgagcctggt
    18421 tcgaccgggc gccgtccctt cgctgaacat gggactgatc cgttcgacgg aggtgccttg
    18481 gagctggacg gaaaaccagt ccctcgggac tgcgctaggc gggctccgag ccgaatctcg
    18541 tgcgctggcg gctgaggctg ccaggcttcg taccgcccgg gcagccctgc tgtcgggtct
    18601 actggatcgg agcatcgaca tcgagtccgc cgagccggag gtctgatccg tggcgaaggg
    18661 catcagggag cgtgagttcc agaacctgat gatccagtgg tccctcccaa tgggctggga
    18721 gttcaccgca ggcaggtcgc tggcgcgtga aacgacgcag acggtggtcg ccggacagct
    18781 gcgggatgcc atcgtccggc tcaatcctgg ggtgatcgac gggttcgacg tggacgcagt
    18841 ggtcgaggag gtcgtcgcca cggtcaacgt cgtcgagggc ggtctggtgc gggccaacga
    18901 gcaggtgctg cacctgctgc gcgggcgcaa ggagttccgg gacgccgacg gtgtgtggca
    18961 taccctgaag gtcatcgact tcgaacaccc gaccgccaac accctggtcg tctcggacga
    19021 ggtgaccatc accgttcccg gcaagacctc ccgccgcttc gacctcgtgt actgggtcaa
    19081 cggcctgccc ctagtcgtgg tggaggtgaa atccccgacc gcgaagtccg cgtgggccga
    19141 tgccgcccgc gagatcaacg acgtttacgc caccgagtac ccgtggttct tcacccctaa
    19201 cgtcttcgcc gtcgcctctg acgggctgaa tctgcggttc ggtgctgccg gagcgcccac
    19261 gaccctgtgg catccgttcc ggtccactgc ggatgacgag aacctgtccg ggcaggccga
    19321 cgtgcagcgc tccgtcgagc tgctgatgag cccggccacg atcctggaca tgctcgccaa
    19381 cttcgtcctc ttcgacacct ccgggggtgg ggcggacaac aagtatcttt cgcgctatcc
    19441 gcagatggag gccgcgcacc tgatccacaa gcgggtcctg gagggcgggg cgaagggcct
    19501 gatctggcac caccaggggt ctgggaagac gctgctgatg gtgttcaccg cctcgctgct
    19561 gctgaccgac ccccgtaccg agtcgcccac gatcatcctg ctctcggacc ggctccagct
    19621 cgtccggcag acctcggggg tgttcacctc cgcgatgggg gacgcctact tccaccagcc
    19681 cgccactggt cgggagttgc gttccctgct ggccgacgac gtgcgcggcg tcatctccac
    19741 gaccgtccac aaattcgccg acgccggcaa gaacctgtcg acccggggca acatcatcgt
    19801 gctggtcgac gaggcacacc gcacgcagtc caccaggtcg aagtccctgg ccgggcagat
    19861 gcgcgcagcg ttgccgaacg cgaagttctt cggcatgacc ggcaccccca tcaggaacct
    19921 cgccaccgac accttcgccc tcttcggcga gcagaccgac ccggacaggg tgctgcaccg
    19981 gtactcggtg tcccggtccc tgctggatgg ggcgaccgtt ccggtcatgc tggaccctca
    20041 cccggtctcc ttcgagatga acgaccaggc gttgcaggct gagttcgatc agtttgccga
    20101 tgacttcgac ctcgacgatc ccgatcgtga ggccctgtcc cgcaagttcg ggcgcctcac
    20161 ctcggtgttc gctagccccg accgtatcca cgcggtctgt cagcacatcg tggaccacta
    20221 cctgtctggc gcttaccgca acggcctcaa ggcccaggtc gtcgcctaca accgtgagct
    20281 ggccgtggcc tacacggaca agatcaacga gctgttggcc ggctttgagg cgtcacaggt
    20341 gctcgatgaa gtcgggaagc atgatcggat caccgccgag gtgaacatct ccgtctcgga
    20401 ttccaaggac gaaaaccccg ccatgcggcc gttccagctc tcggaggccg aggaggagga
    20461 gcagaagcgg cggttcctca ccccggacga cccgctgtgc ttcctggtgg tgaccgcgaa
    20521 gctgatgacc gggttcgacg cccccaacga gggcggcctc tacctggaca agccgctgaa
    20581 ggcccacacc ttgttccaga cgatcacccg accgaaccgc ccctgggtgt ccccgaccgg
    20641 gttcgtgaag acctccggcg tggtcgtgga ctacatcggc ctagccgaag aggtccagcg
    20701 ggccgtcgct gaccccacct cgaagggagc cggtaagggt ggcgggttcg tcaccgacct
    20761 gaccgagctg gtcgccgagt tccgcaccac cttcgcccga atcgaagatc tcctcgcgga
    20821 cgtggacggc ctggacctca cggtccatgg gtacgagtcc gtgcgagcca tcaacgtctt
    20881 cttggacgcc aaccctggcg ccgccgaggc gttcgccaag gactaccggc tcctggcccg
    20941 cctgtacccg ctcatcaata ccgacaagcg catcgccaag taccgggacg gcatcgggct
    21001 gttcgggtcg gtgtacacga cccttttcaa gaagtcctcc gaggaggaga ggaaggaacg
    21061 gctgagcgag ctggggccga tggtcctgga gatcatcaac gcccacgtcc actccttctc
    21121 cgtggtcgcc tcccaaaggg aatccctcgt actggacgcc cggggaatcg ccctgctcaa
    21181 ggagctaatg tccctcgtcc gccccaagcc aggcaaggac gacagcgacg acaagacgcc
    21241 gccgtccgcg gcggagatcc tggaccacat caaggccgcc ctcgaaaagg gcgtcgaacc
    21301 ggagtcggcg aagtacaccg cccttgcgga gcggatcaag ctgctgcggg accggatcat
    21361 ccagaacgcc caggacgccc tggagttcct gtccgaagct ctccgggtcg cccgcgccat
    21421 cgtggacgcc gagaaacacc ccgacgaagc tgtcgtcgtg ctggacgacg accacgtggg
    21481 tgtcctgtcg cggatcatcc acgaccacgc accgtccggc ctcacagtca cggagaggaa
    21541 cctggccgaa gagatcgacc aggtggtcac ccgcaccctc gcccggtcgt gggacaacgc
    21601 cgaggctcgc aaacgaggcg tccgccgcgc caccgctgcg gtcttccgcc ggtacaggtt
    21661 gaagccggtg ggtgagccgt atgactccac tgtcgcctac atcgaagccc actacctcgt
    21721 tgactgacga atgcacgtgg cccggcaacc tatggccgtt gccgggccac gtcgcgttgt
    21781 tcgggccctg acctattccc tgagccgcag aaagctcgaa tgcggcaagt gcccgaacag
    21841 catcgttcgg gcacagcaac agacctgcgc cgaggcgcat agacacctcc ggtgacatcg
    21901 ccgcaggtcg gccctcgtcc gaaggttctc gtcgaggtga gcgtccattg gggctgatcg
    21961 cgccgcgaac ggcagcgccg ggtcttggga agggccttca tgccgattac cgccaccgca
    22021 tccgtgcagg acactgggcc gttggggctg gtccggcccc gcccgcggag tccaccgagc
    22081 ccacgcgggt gttcgggggc gcacacacgc caccagcgcc cccgtggggg tacatgcgcc
    22141 ccgggcaggc gaacagcctg taggcggccg tcggggcggc gcaggggcgg ccgcgaaggg
    22201 tctgttcgcg acactgcggg cggcgggggt gggccgggtg ttcggggcgg tggacgcccg
    22261 ggtgtcggtg gtgtcgctgc cgggcaggat caccgtgtgg gtgcgcggcg ggacgttcac
    22321 ctggcgggac gccgacgggc gccaccagac ccacgcctgg acggaccctc agggggagcc
    22381 caaccaagcg gtcaagccgg cgcgcgccgc caactccacg tccgcgcgac gctgcctcta
    22441 cgttccccag gaaggtgaat gattgtgtcc gggacgtcct gctcccggac acaatttcag
    22501 cttgggaaac cgagagccgg ccttccggat ttcctgcggc ttcctggcct gcggttttca
    22561 ggctggtaac ccttcattcc cgcggctatc cgtcgttcac cgtcctgtgt ggcacgtgcg
    22621 ggcacggaag cggggagact gggcggaagg cagagcgttc tcgggcctcc tccccgatgg
    22681 ttgcgggagt cgaggcgacg gcgattagtc ctaccggcct gtgccccctc agttccacat
    22741 ctcctttccg gcgcattgga cggggccgac cgttctggtc ctgcccctgt ctgcggtggg
    22801 cttccgcatc gatgcggcca tccgaagcct ccgcaatgac tgagcgctgc gccctgccac
    22861 ggcggaccgg gaagcctcct cactgcgtag aggagggcgg ataccaggcc cggccagctc
    22921 gcgccgtgat cgcgggccag ccgcccgcag taaccagtgc ggtgggcagg acggtaccgg
    22981 cccgaggtcc ccgacagcgc cgtggcggcc acccaggaca gtcacactcc actgtcgggt
    23041 gcctcgggat cgcagcaggt caggaaccaa ggtgccagaa aaagtggtgt agatgcgcgc
    23101 tctgggtcac catggaccta gctggcaccc ctgattccct gctcactctg tgggggtgcc
    23161 ttcacaacag ctatacgcgt ccgaaggcgg ctgcggcggc gcttgcaccg cttcctctat
    23221 cccttacagt ccaactcgga atacatatag caggaggaaa gaaatgggag acccgaggaa
    23281 gatatttctt tttctgggga cattttctca ggagggcttg cggagcaagc tcaatgtaac
    23341 ggatgtttgg tacgttacca aacgcatgga atcgtccccc gaaaactggg agaaaatagc
    23401 caaaatactc gaaaatccaa accttgtcgg cgtacttgga aagtttggcc gaggggccta
    23461 tctgcgaatg gggtccgatg agcacttgga agtcgccaat ggaatgctcg agaatctgag
    23521 caaggtgcca cacatcattt ttattcacga agacataata aacggtgatg cggccaggaa
    23581 ttacgtggag ccattgcctg ttgccgatgc aaagggagag ctgtacagaa cttcattcga
    23641 tgcctgcatg tcccagattc cagaagaaaa gacgatcatt acaaatgatt tgctaaaaaa
    23701 gcacgagatt caagtggcct cctataagaa gaattctgaa ctctacgttc tcgcagattc
    23761 attcattgaa gacttggaga ataatctcct tttcaggatt tacgtgccaa agggaaggtt
    23821 gtactcaaat gaaatgtcgc gcctcctaga tctttttcgg gagtggttga caacagtcaa
    23881 gaaagaaaag attagacaag atggatacaa gacaagccgg gggcaagtct ttgaattttt
    23941 cagtgaacgg aatctcggaa aagaggaggt agctgaagaa attcgggagt ttggtcgatt
    24001 tcttgacctt tgtgactacc cagatgaagc cgcccttgta cttcaaggaa taggagttga
    24061 gaagagcggt gcaaccgaac tcgtggggag gtacgccaag gaagttcggc gcttgagaat
    24121 tgatattaaa caggagaggg agcaaagggt tatgcaaatt aggcatcgca tggagtctga
    24181 aattgtagat gaagcagaca ggcctgagat tcactggagg gcagtgagca acctggtggc
    24241 aagtatgatc cccgaagttc ctggcgatct tacaaatctg atgacacgtt atgcgataga
    24301 cgagaatagc gagcggactc cgattcagat aaatcaacaa ataataggtc gggcatgcgg
    24361 agaagttagc caaaatgttg ccggcacgca gcattttggg ccggacgcgc aagctctaat
    24421 tgaaatgatt cgcaaccatg gtggagctga ggaggcagag cttgttgcct ccgtccatga
    24481 agtttccgac gaagaagcta ggatgtcgga tcgcctgaca gcaaagcata aaatcaagag
    24541 atttcttctt cgggcaagag acaatgttga aacaacggca tacagtctgg cgcaatcata
    24601 tattgaatct cagatgggac tttagtcctc tattcgtatc agatgtcttt catctcgaac
    24661 caggtcttgc ggcctgagag ggtgccgtgg ctgcccttgc ctgtctgccg ctgcgtcttt
    24721 cgaaattccg ttgctgtacg ctcgtgtgca cgcccaacgc gggggcaggt cgatcagccc
    24781 ttaacccgcg ctcggcacag ccaggagtgg tgcgcttgac cagtacggaa tcgcctaccg
    24841 gttttccgag agcattgctg ggcgcgactt gaatccgttc accgtactcg ccgtgatcgt
    24901 cttcgcccta aatcccgttg ttccgggtct tcatgacggt aatcccgaag tcgattgaca
    24961 ggagatccat ccaccgtatc ggttcgcccg ggctgtagaa attacctcta agttgtcgtt
    25021 ttggcagttt gatgattggc cttccaggga caccgtagct gagttccaag cctggctgga
    25081 aagacggacc ggcctgcgca tggggggcgg ttaccccgcc tctgtcaaga aactcctcat
    25141 tgcgtgaatg tgcgactaat cgatcccatt acgtgcaacg catcccgggg ctcacattgt
    25201 tcttttctgc tgaccttcgg cgcgagcgaa gtgagaaccc ccacctgctc tctcacctcg
    25261 gggtgcattt ccttgattcc gatgcctgtc gcttcgtagc ccccgaacgc ggca
//
