LOCUS       NZ_CP022753            25995 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Nocardiopsis gilva YIM 90087 chromosome, complete genome.
ACCESSION   NZ_CP022753
VERSION     NZ_CP022753.1
KEYWORDS    RefSeq.
SOURCE      Nocardiopsis gilva YIM 90087
  ORGANISM  Nocardiopsis gilva YIM 90087
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     The complete genome sequence of Nocardiopsis gilva YIM 90087
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2017) Yunnan University, School of Medicine, 2
            North Cui Hu Road, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 208.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002263495.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 21:04:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,549
            CDSs (total)                      :: 5,470
            Genes (coding)                    :: 5,345
            CDSs (with protein)               :: 5,345
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 61 of 125
            Pseudo Genes (incomplete)         :: 66 of 125
            Pseudo Genes (internal stop)      :: 5 of 125
            Pseudo Genes (multiple problems)  :: 6 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3127701
            Orig. end                         :: 3153696
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25995
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="14"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..25995
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25995
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15995](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15995)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(59..75)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.15"
                     /tool="antismash"
     gene            132..1109
                     /locus_tag="CDO52_RS14260"
                     /old_locus_tag="CDO52_14245"
     CDS             132..1109
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621168.1"
                     /locus_tag="CDO52_RS14260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14245"
                     /product="DMT family transporter"
                     /protein_id="WP_017621168.1"
                     /transl_table=11
                     /translation="MIISFPGLLRRAQTRVPAPLLFVCGMFALHTGSSLAVTLFGEVGS
                     LGVTWLRLSWAALILIALSGRPLWAAVRAASTHELVTVVILGTVSAGMMALYSEATARI
                     DLGTATAIEFLGPLAVAVLAMRRGREFIWIVFALVGVLFLTQPWNGKADLTGVAFGLGG
                     AVCLAFYIVFTQRVGGTFRALHGLALSMTVAAVLTAPVGVPDVVAHPSPHALLVTLGIA
                     LLFPIVPFLLEMVVLQRISRVAYSTLASLDPAVSLVMGMLIIHQTPGWAQFGGILLVVI
                     AGIGAARGDSAVTEPPLPEQSVLGEDRSLPSAAAERPHPDISHR"
     gene            complement(1132..1347)
                     /locus_tag="CDO52_RS14265"
                     /old_locus_tag="CDO52_14250"
     CDS             complement(1132..1347)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621167.1"
                     /locus_tag="CDO52_RS14265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14250"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_017621167.1"
                     /transl_table=11
                     /translation="MTQLVQSARDDASPLTALIATVQLRAEVERLQAVHVRRARLQGAT
                     WSEIATILGISKQAVHKKYGGSRREK"
     gene            1466..3265
                     /locus_tag="CDO52_RS14270"
                     /old_locus_tag="CDO52_14255"
     CDS             1466..3265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019611123.1"
                     /locus_tag="CDO52_RS14270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14255"
                     /product="hypothetical protein"
                     /protein_id="WP_094932441.1"
                     /transl_table=11
                     /translation="MSERTDLELLRAFEPVLRYTKGELFFPTDVAAYVRTCSLWAEDDG
                     GKERELVPAGQLTLDRLAGAEEEWPGRYKHLRFVQEDTLRDEARRFRSTARPGIPKSGR
                     LAAVGVFGRIVDVLVKFSLLIRGAVPGGLAAAAVTRYREQVDPGNATYYGRVVRDGDYI
                     ALQYWFFYAMNDWRSIYGGVNDHEADWEKVTVYVVETPDGAVRPAWVGASSHEYTGDDL
                     RRSWDDPDLNRENDHPVIYVGAGSHSHQMLPGDYLIQVDPAPLRGVVRAWRNFTARLFP
                     HTSQPGRHGIGVPFVDYARGDGVRVGPGGDREWDAVLVDDDTPWVHGFRGLWGRDTRDW
                     FDGERAPSGPRYERDGTVRYSWADPLAWVGLQKVAPTDAAARLELTAHLKELNTRIDEA
                     DDEILERRDRLRRLAAAQCVLRRDPHAHARTREYGDLIEKEERELAALYRERALKADER
                     DAHAKALDSDEPVIAGPTAHLRSPHLPYATGDQRTTRFVHIWVALSTPLLITALGAMLL
                     MHGPYTIPVMIGVVLLFAAFDSFARRKLRTFLAGLAILALVAGAVTGIILAFMADWRIT
                     LLVPIIAVVAGLLVVNVRDLLRR"
     misc_feature    complement(1469..1483)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    3304..3324
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            3420..4456
                     /locus_tag="CDO52_RS14275"
                     /old_locus_tag="CDO52_14260"
                     /pseudo=""
     CDS             3420..4456
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046917 - triphosphoribosyl-dephospho-CoA
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013991.5"
                     /locus_tag="CDO52_RS14275"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14260"
                     /product="triphosphoribosyl-dephospho-CoA synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSVVDPAQETSARSGPDPSVDARPDPASGPRAARLAGHAVRALVE
                     EAALTPKPGLVDRRGGGAHPDMDLRLMERSAEALRPAFALMAAACDGRAPDEALRRRLG
                     ALGRRAEEDMLTATGA"
     gene            4537..6228
                     /locus_tag="CDO52_RS14280"
                     /old_locus_tag="CDO52_14265"
     CDS             4537..6228
                     /EC_number="4.1.1.88"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013225.5"
                     /locus_tag="CDO52_RS14280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14265"
                     /product="biotin-independent malonate decarboxylase subunit
                     beta"
                     /protein_id="WP_094932832.1"
                     /transl_table=11
                     /translation="MRRTPIAGGTPYTGLTARERARALLDPGTFRELLGPADRLVSPHL
                     APQGIIPQADDGVVVARGAIDGAPAVVLSLDGTFLGGAIGEVCGAKIAGALELASRAAA
                     AGGTVRTVLLLETGGIRLQESNLGLLAVADIHAAIVDLRRHAPVVGVISGRIGCFGGMA
                     IAAGLCTRLIMTAQGRLGLNGPQVIEEEAGVSELDAADRDLILRTVGGRRRTADGFADA
                     LVDDDTGEMRAAVRSACAATAPDASAHRSARVAEFTERLAGCAPGEDARPDTAAGPAGT
                     ADTEAAAKDRRGGVWIAALTGAPVTASAEGPASVLAADGELAGRAARFLAVVPDPDARW
                     PRARAGEVGLDEGLALAARVRAAVRADAALPTEEKRAIVAIVDTPSQAYGYREEVHGIH
                     QALAAAVDAYAGARHAGHPVVALVVGHAISGGFLAHGLQADRIVALDDPAVVIQAMSKE
                     STARLTRRTLPELDAIAREVPSTAYDVRSFAALGAVHRLVTGVDGDAPGADTVGTATVR
                     AALEDAVADARSAPAGLSVRLCSAEARRNRAASLDVRRRLAETWDH"
     gene            6545..7249
                     /locus_tag="CDO52_RS14285"
                     /old_locus_tag="CDO52_14270"
     CDS             6545..7249
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF002332.0"
                     /locus_tag="CDO52_RS14285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14270"
                     /product="malonate decarboxylase holo-ACP synthase"
                     /protein_id="WP_017621165.1"
                     /transl_table=11
                     /translation="MDPAVFSGARPHDLLRFDDPGAVLPEGPELELPMWAVSVLRDVPW
                     VVVRRGIAAAGRIPVGIRGVRRADRVAAFLPESAVVERFTPEQAARSHPRLPDERKAAV
                     PALGALTRLDMILRRHVPSWGIGGSAGFEIVTGLPVTLPGSDLDIVIRPREPLPLLRAA
                     TLLADLRALPVRVDVQLCSTEGAFALVEYARGGPVLLRPLDGSPPQMVEDPWPYPADPT
                     SSARVTRPREGR"
     gene            7679..8833
                     /locus_tag="CDO52_RS14290"
                     /old_locus_tag="CDO52_14275"
     CDS             7679..8833
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621164.1"
                     /locus_tag="CDO52_RS14290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14275"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_152471855.1"
                     /transl_table=11
                     /translation="MTITRADGAPSGPTIGAEEEFFVIDAATYQARSRAPEVLSGARTR
                     CCGGRRGSTVSAEITQVQVETATPVCRTGRELYGHLVAARQSLAEAARDHGLHIAATGT
                     AVIGDAACAPVTENDRYTRIVASYGAMRDARAVCGCHIHVGIADRETAVHVANHLRAWA
                     PVLVALGANSPFRLGRDTGHASWRAIAWAMQPSAGPPPVMRSAAEYDRAVDDMLISGAM
                     LDRHMVYWDVRLSAHLPTVELRAVDATSTAEEAVLIALLVRGLTVVALRHVADGRSAPE
                     PSDQTLRLSVWRSAHDGLEGEAFDPFRRELVPARRLAHQMLEQAQQGLVSADADFAGRL
                     LARLLAVGSGAHRQRAAYARRGRLTDVVDLLVRQTRHGLAAVEG"
     gene            complement(8897..9556)
                     /locus_tag="CDO52_RS14295"
                     /old_locus_tag="CDO52_14280"
     CDS             complement(8897..9556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621163.1"
                     /locus_tag="CDO52_RS14295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14280"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_017621163.1"
                     /transl_table=11
                     /translation="MSDALFAVPAEPVEVSPGAVHVPGWLSTETQRRLVELCREWSRGP
                     AGMRRHRMPRGGMMSVRMVSLGWHWEPYRYSRTLPDGEPVAPFPSLLGELARAGVADAY
                     GAPLASGTPDYDVALVNYYDADAKMGMHQDREEQADVPVVSLNLGDACVFRFGNTENRS
                     RPYTDVELRGGDLFVFGGPSRMAYHGVPRILPGTADPDVGLAKGRLNITIRASGLE"
     gene            complement(9692..9826)
                     /locus_tag="CDO52_RS14300"
                     /old_locus_tag="CDO52_14285"
     CDS             complement(9692..9826)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039607.4"
                     /locus_tag="CDO52_RS14300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14285"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_017621162.1"
                     /transl_table=11
                     /translation="MSYILDLQSMEGPVTENGDQPMQESRLSVITCGGLSQLSALLCD"
     CDS_motif       complement(9770..9826)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSYILDLQSMEGPVTENGD"
                     /locus_tag="CDO52_RS14300_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9692..9769)
                     /prepeptide="core"
                     /locus_tag="CDO52_RS14300_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="5.40"
                     /molecular_weight="2560.0"
                     /monoisotopic_mass="2558.3"
                     /core_sequence="QPMQESRLSVITCGGLSQLSALLCD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSYILDLQSMEGPVTENGD"
                     /leader_location="[9769:9826](-)"
                     /alternative_weights="2578.0"
                     /alternative_weights="2596.0"
                     /alternative_weights="2614.0"
     misc_feature    complement(9713..9715)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12676)
                     /gene="lanKC"
                     /locus_tag="CDO52_RS14305"
                     /old_locus_tag="CDO52_14290"
     CDS             complement(10001..12676)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621161.1"
                     /locus_tag="CDO52_RS14305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14290"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_017621161.1"
                     /sec_met_domain="micKC (E-value: 1.3e-239, bitscore: 795.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1e-14, bitscore: 52.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.2e-05, bitscore: 23.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.4e-15, bitscore:
                     54.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLDYFQYCLDDRLFYDDPGNRKTDCTPYTCPPTPSNESWSISAE
                     YPWIHYIRQDDELPPQGWKIHVSANLESPQKVLDITSDYCFSTGISFKFLAHEGAFLAQ
                     NHKYADRSGSGKFITIYPPSDVELHAALNELSPRLHGLGGPYILSDLRWKDGPLYVRYG
                     GFQFRHVRNEWGESVPAIEDPEGRLCPDRRAPVFSCPDWVDPPEFLRPLLEERRDSEPP
                     ADFPYVIRSALHFSNGGGIYLADDQKSGTKVVLKEARPHAALDPAGRDAITRLRHEYDM
                     LTELADIDVVIDVHGRFTVWEHEFLVQEYAQGGTLNSEVVRRHPLIRPEPDSAAKADFT
                     RWALDITAQVERAVEQLHERGIAFGDLHPGNVLLRDDGRIALADFELATRGEEGARIGL
                     GAPAFTPPDRRGAFATDRYALGCVKIAPFLPLTMLCALDTGKARTLVETVEELFPVPAT
                     WGRDVLADLDVGPSPWAGMPEQMARSAALISGEGHRRPHPRERRPEEPERPDWPAIEAS
                     IARAIRASSTAERTDRLFPGDVEQFTTSGLGLAHGAAGVLYALSVSGHSRHTEPEEWKT
                     WVEWIVRRVRAQRPPHRLGFYDGLHGIAYALEKIGLRDEALETLETAAHGEDRTTLADG
                     LFSGLSGIALNRLHFFRRLGDRSLLDTAVNDAQLLADRLAQGPAHGAGHKRGGRGPAGL
                     IRGPSGSALLFIHLHRETGDHGYLDLAQQALEQDLRACAHNEADDTLGVDEGHRTMPYV
                     ADGSAGIGLVIDEFLRHRDNPTFTTALARIRRAAEPELAVFPMLFQGNAGLLGLLTHLR
                     RPETRDERLEELIAMKRDRLRWHMVGLRGEIAFPGDQLLRLSMDLATGSAGILLALATV
                     RDDRVPILPFLTRAARSPDG"
     misc_feature    complement(12727..12740)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.88"
                     /tool="antismash"
     misc_feature    complement(12728..12742)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.87"
                     /tool="antismash"
     misc_feature    complement(12734..12750)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.31"
                     /tool="antismash"
     misc_feature    12734..12750
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.87"
                     /tool="antismash"
     misc_feature    complement(12761..12774)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    complement(12816..12832)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.69"
                     /tool="antismash"
     misc_feature    complement(12824..12837)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.91"
                     /tool="antismash"
     misc_feature    complement(12893..12906)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.38"
                     /tool="antismash"
     misc_feature    complement(12895..12908)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.95"
                     /tool="antismash"
     misc_feature    12931..12944
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.02"
                     /tool="antismash"
     gene            complement(13052..13150)
                     /locus_tag="CDO52_RS14310"
                     /old_locus_tag="CDO52_14295"
     CDS             complement(13052..13150)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621160.1"
                     /locus_tag="CDO52_RS14310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14295"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_017621160.1"
                     /transl_table=11
                     /translation="MSYILDLQSMETPVAESADQAYSVSYLSLLLC"
     CDS_motif       complement(13094..13150)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSYILDLQSMETPVAESAD"
                     /locus_tag="CDO52_RS14310_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13052..13093)
                     /prepeptide="core"
                     /locus_tag="CDO52_RS14310_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.10"
                     /molecular_weight="1405.6"
                     /monoisotopic_mass="1404.7"
                     /core_sequence="QAYSVSYLSLLLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSYILDLQSMETPVAESAD"
                     /leader_location="[13093:13150](-)"
                     /alternative_weights="1423.7"
                     /alternative_weights="1441.7"
     gene            complement(13335..15995)
                     /gene="lanKC"
                     /locus_tag="CDO52_RS14315"
                     /old_locus_tag="CDO52_14300"
     CDS             complement(13335..15995)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621161.1"
                     /locus_tag="CDO52_RS14315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14300"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_026126281.1"
                     /sec_met_domain="micKC (E-value: 4.1e-240, bitscore: 797.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1e-15, bitscore: 56.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-14, bitscore:
                     50.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLHYFQYCLADRLFYDAPGSREADRSPYTCPAPPAGRSWSTSDD
                     GTWIHRMRQDRQPPPQGWKVHVSANLKSAQKVLDITSEYCLSAGISFKFLSHEGVFLAR
                     NAKYADRSASGKFITIYPASDDELHAILNELSERLDGLGGPYILSDLRWKDSPLYVRYG
                     AFTIRYVRNERGEPVPAIEDPLGRLCPDRRDPVFSFPDWVRPPHFLRPLLEERSASGPP
                     ADFPFVIRSALHFSNGGGIYLAEDRASGAQVVLKEARPHAALDQDGRDAIARLRHEYDI
                     LTQLADVDAVVGLHGRFTAWEHEFLVQEYVGGGTLSTEMARRNPLARPDPDTAAKADFT
                     RWALDITAQVERAIERLHDRGIAFGDLHPGNVLLRDDGRIALADFEVATRGDEDGHIGI
                     GAPAFTPPDRRGAYAADRYALGCVKIAPFLPLTMLCALDTGTARSLVDAVEDLFPVPAG
                     WGRDVLADLDLGPSPWAGTEEQMARSTALITGAEHRRPDQGDDRRPSASGRPDWLAIEA
                     SIARAIRESATPERPDRLFPGDVEQFTTSALGLAHGAAGVLYALAASGHGRHAGPEVWD
                     MWEGWLLRRVREQRTPHRLGFYDGLHGIAYALEEIGLRDEALETLETAAPDEEHDALAD
                     GLFGGRSGIALNRLHFFRRLGDRSLLDAAVNHAQRLADRLTDPAARGAREAAGLLRGPS
                     GSALLFVHLYRETGDHGYLDLAHQALERDLRSCVRLERDDTLLVDDGQRTLPYVADGSA
                     GIGLVLDEFLRHRDHPPFTAAVARIRRAAQPELGIFPMLFQGNAGLLGLLTHLRRADGH
                     DAHLEELITAKRDRLRWHMVGLRGEIAFPGDQLLRLSMDLATGSAGILLALAAVRDDHL
                     PILPFLTRATATSTR"
     misc_feature    complement(15432..15434)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15976..15989
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    15976..15989
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.54"
                     /tool="antismash"
     misc_feature    complement(15987..15989)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(16245..16258)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.06"
                     /tool="antismash"
     misc_feature    complement(16255..16271)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.65"
                     /tool="antismash"
     misc_feature    16258..16271
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.39"
                     /tool="antismash"
     misc_feature    16263..16276
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.08"
                     /tool="antismash"
     misc_feature    16270..16285
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(16277..16291)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            complement(16369..17562)
                     /locus_tag="CDO52_RS14320"
                     /old_locus_tag="CDO52_14305"
     CDS             complement(16369..17562)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621158.1"
                     /locus_tag="CDO52_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14305"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_094932442.1"
                     /transl_table=11
                     /translation="MDEFEAPGPERARRWRLVLGEPAAEACGGLGAADTGMDGALAALY
                     DRGSDGARDGSRQGGLGGSAPRVARWLGDVRSYFPSSVVRVMQADAVDRLGLERMLLEP
                     EMLEAVEPDVHMVGTLLSLSRVMPEQARESARAVVRSVVEDLERRLAQHTRSVVQGALD
                     RSARTHRPRRVADIDWNRTIRANLKNYLPERRTVVPERLVGYGRRSRGVERDVVLAIDQ
                     SGSMAASVVYAGVFGAVLASMRTLSTSMVVFDTSVVDLTDRLSDPVEVLFGTTLGGGTD
                     INRAIAYCQELITRPSHSIFVLISDLYEGGVREEMLRRVAAMTAAGVQVVVLLALSDEG
                     APSYDRQNAAALAALGVPAFACTPDRFPELMAAAVQGRSLTAWVEQEQAAEASTAQT"
     misc_feature    complement(17664..17677)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.75"
                     /tool="antismash"
     misc_feature    complement(17666..17679)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.88"
                     /tool="antismash"
     gene            complement(17741..20047)
                     /locus_tag="CDO52_RS14325"
                     /old_locus_tag="CDO52_14310"
     CDS             complement(17741..20047)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017534429.1"
                     /locus_tag="CDO52_RS14325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14310"
                     /product="DUF5682 family protein"
                     /protein_id="WP_094932443.1"
                     /transl_table=11
                     /translation="MARVDTDRVHVLGVRHHGPGSARAVRAALEEIGPDAVLIEGPPEA
                     DGLTGLVGELEPPVSLLAYVPDAPARAAYWPFASFSPEWVALRYAAEHGTEVRFCDLPA
                     AHTLAEGDAAGAGGPEGPDTPGRGDAPEEDEASAAARRSRVDPLGVLAEAAGYDDPERW
                     WDDVVEQRGAAGADAPSPFPAIAEAMAAVRAELAPEPEDEREARREAHMRKVLRATMRA
                     GYARIAVVCGAWHAPALLDHPRVADDNALLRGLPKVKAAATWIPWTHGRLAAASGYRAG
                     VRSPGWYHHLFTAPDRPVERWLAEAAERLRAEDQPVSSAHVIEAVRLSDSLAALRGRPL
                     PGLDELAEATSAVLCEGSELRADLVHRSMVIGERLGTVPEATPMVPLQRDLVAQQRRLR
                     LKPEAVERDLDLDLREERVRQRSVLLHRLRLIGVDWGTPRGDAPRSRGTFRESWTLRWT
                     PELDIALIEAARWGTDVASAAGARALDLTRGADLPRLTRITEQCLLADLPDAIGDVLAA
                     LAAGAAEDTDIEHLMAALPPLARSARYGDVRRLDSEALRRVAEQLLARVCAGLGPALSG
                     LGDDAAGRMVRGVDDVHAAAVLLGGVAEREWADALAGVAGREDIPGRVGGRAHRILYDA
                     GRLADTELAARLAKATSRAVPPERAAAWIEGFLSGSGLLLVHDTALLSLIDRWLTGLGE
                     QAFTEVLPLLRRTFGAFPAAERRSIGERARGLGRGRSTAEATPDDIDTARAAPAVATVA
                     TLLGLPEKALARTGH"
     gene            complement(20047..21144)
                     /locus_tag="CDO52_RS14330"
                     /old_locus_tag="CDO52_14315"
     CDS             complement(20047..21144)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621155.1"
                     /locus_tag="CDO52_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14315"
                     /product="AAA family ATPase"
                     /protein_id="WP_094932444.1"
                     /transl_table=11
                     /translation="MSSSAPTAPLRPHAEQNYADELAALATADDRPRPPGWRLSPWAVT
                     RYILGGTLDDGTVISPKYIGARRVVEVAVATLATDRALLLLGVPGTAKTWLSEHLAAAI
                     AGDSTLLVQGTAGTAEEAIRYGWNYARLLAEGPSEAAMVPSPVMTAMAEGRLARVEELT
                     RIPSDVQDALITVLSEKTLPVPELGTEVQARRGFNIIATANDRDRGVNDLSSALRRRFN
                     TVVLPVPRTVEEEVDIITRRVADLGRSLELPEVPAGMTEIRRIVTVFRELRGGVTEDGQ
                     SKVKSPSGTLSTAEAISVVTNGMALAAHFGDGTLRPADVAAGIHGAVVQDPVSDGVVWR
                     EYLETVVRERDGWQDFYRACRETGR"
     gene            complement(21141..22424)
                     /locus_tag="CDO52_RS14335"
                     /old_locus_tag="CDO52_14320"
     CDS             complement(21141..22424)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039502.4"
                     /locus_tag="CDO52_RS14335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14320"
                     /product="DUF5691 domain-containing protein"
                     /protein_id="WP_232524176.1"
                     /transl_table=11
                     /translation="MPRTCCGAGARAPGDAAGGQRGRRSAVGPVDQCGTRSQLREWLAL
                     VADRGLRVPPEALPDLLERGARDHAFGRLVLAVSGERGRWLARLNPDWSYLERLVPPGE
                     FTADEWRRESVERRRALLESLDDRLSPADEPLLTEALTDRSTRVRALAMALLARLPDTA
                     HGRHLAAHARRHVLPGEHGRLSVRLPDLADTELARDLNVTAPADGDPRKEIRREWLWTL
                     ISHTPLDTWVGHLGTDRAEVVREVSGSGDLADALANAAVVQRDLDWARLLLPTVLDRLT
                     RGHDLRGSRGPALLALLPAAEQCAWAVRQARADRASASHLLNIVEQLDCPWTEELGAIV
                     VDTLLGTKAGAERTTSAYTQLAAAAERWLLPTLHTRFAEYGAPADAGEGTGSTSADSPE
                     SGDDRKGRTLARLAATLRFRYEMHEELN"
     misc_feature    22828..22837
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    complement(22968..22977)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            complement(23147..24472)
                     /locus_tag="CDO52_RS14340"
                     /old_locus_tag="CDO52_14325"
     CDS             complement(23147..24472)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019611161.1"
                     /locus_tag="CDO52_RS14340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14325"
                     /product="SWIM zinc finger family protein"
                     /protein_id="WP_094932833.1"
                     /transl_table=11
                     /translation="MSERWNTDDVAALAPDASSRKAAVKVARTASWPVLGRLAADPTEA
                     ADAPGGTVALWGACAGSGKKPYQTAVHLTGPSAPASKCSCPSRKFPCKHALALLHLWVE
                     GRVEAAGDPPDWVADWLIRRDATTERRDAAPDAEAAARRTQRREERVAEGFAELELWLR
                     DQAQAGLAGAPGRDYGHWDGMAARLVDAQAGRVADRVRELGSVCAKDEWPGRLLTEFAL
                     LRLLITAYRRRDDLPEPLRATVRARAGLVTAPDESAPVRDTWQVLGRRDFPAGQVRGRR
                     IWLRGRATERVAMLVSFAPTGRTPETAARVGTEFEADLAFYPAERRASLVARHAEHRAD
                     PPPGGSLDDALKSWASAVAADPWLEEWPVVVRDAAVAHRDGWWLTDPSGAALPVHRAVA
                     PSQPWRLAAVSGGAPLTVAAEWTPSGLRPLTAWTAEGRAVPM"
     gene            24673..25680
                     /locus_tag="CDO52_RS14345"
                     /old_locus_tag="CDO52_14330"
     CDS             24673..25680
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017594859.1"
                     /locus_tag="CDO52_RS14345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_14330"
                     /product="methyltransferase"
                     /protein_id="WP_094932445.1"
                     /transl_table=11
                     /translation="MVGGETEGRDLLRLLAGPWLTEAAVTAVRLGVIDRLGDGPETPAE
                     TAAALSLSPEPLARVLRLLTAAGVLSEEGGRYALTEMGEQLHSDHPASMRPLALLYNSD
                     FFTRAWRGLSDAVRTGEPAFPAVHHQGIYPYLADHPDDEALFDAGMAAGSSFATGLPAA
                     YDFSTAKKVVDVGGGDGTLLAAVLRAYPHLHGVLFERPPALHGARERLGPLIAEGRCDL
                     VEGDFMREIPGDGDIYILCRVLHNWDDEACHLLLGNCRAAMGPDARLLVVERVIPDGRH
                     PLLTLAFDVHMMVMTSGRERTASEYEALLRPEGLTTADITDLAAEMRLLIARPR"
ORIGIN
        1 cgccgtcatg gtgcccagcc gttcgagctc caccagcagg tgcagccgtg tcagatccat
       61 tcaccaaaag tacaagatga atccactatc ggtccctgga cagaaacata ggccgaagat
      121 ccaatggtcg ggtgatcatc tcgtttcctg gcctgctgcg tcgtgcccag acccgcgttc
      181 ccgccccact cctcttcgtg tgcgggatgt tcgcgctgca tacgggcagc tcgctggcgg
      241 tcaccctgtt cggcgaggtc ggctctctcg gcgtcacctg gctccggctg tcctgggccg
      301 cgctgatcct gatcgccctc agcggccgcc ccctgtgggc cgcggtccgc gctgcgtcga
      361 cacatgagct ggttacggtc gtgatcctgg gcacagtgag tgcggggatg atggcccttt
      421 actccgaagc gacggcgcgc atcgacctcg ggacggccac cgcgatcgag ttcctcggcc
      481 ccctggccgt cgccgtcctg gccatgcgcc gcggccggga gttcatctgg atcgtcttcg
      541 cgctcgtggg cgtgctgttc ctcacccagc cgtggaacgg aaaggccgac ctcaccggcg
      601 tggccttcgg cctgggcggg gcggtctgcc tcgccttcta catcgtcttc acccagcggg
      661 tgggaggcac gttccgcgcg ctgcacgggc tggcgctgtc gatgaccgtc gcggcggtcc
      721 tgaccgcccc cgtcggagtg cccgacgtcg tggcccaccc cagcccgcac gcgctgctgg
      781 tcaccctggg catcgcgctg ctgttcccca tcgttccgtt cctgctggag atggtggtgc
      841 tgcagcggat aagccgggtc gcctacagca ccctcgccag tctggacccc gccgtcagcc
      901 tggtcatggg catgctgatc atccaccaga cgccggggtg ggcgcagttc ggcggaatcc
      961 tgctcgtggt gatcgccggc atcggtgcgg cgcgcggcga ctcggccgtc accgagccgc
     1021 ccctgcccga acagagcgtg ctgggggagg accgctcgct tccgtcagcc gccgccgaac
     1081 ggccacatcc ggacatttcc caccgctgag ccgccgccgg gcggtgtcat ctcacttctc
     1141 ccggcggctg cccccatact tcttgtgcac ggcctgtttg ctgatgccga ggatcgtcgc
     1201 gatctcggac caggtcgcgc cctgcaaccg ggcccgccga acgtgcaccg cctgcagccg
     1261 ctcgacctcg gcacgcagtt gaacggtcgc gatcagcgcg gtcaacggcg acgcgtcgtc
     1321 ccgtgcggac tgcaccagct gggtcatccg ttcctcctcc atacacggaa acctaacgct
     1381 gtcgcgccgc gccggcgtaa cgcccgccac gacgccgcac ttgaaccgaa acgaggggag
     1441 agatccacta gtgtcggggg cagtcatgag cgagagaact gatctggagc tgctccgcgc
     1501 cttcgagccg gtgctgcgct acaccaaggg cgaactcttc ttccccaccg acgtcgcggc
     1561 ctacgtgcgt acttgcagcc tgtgggccga ggacgacgga ggcaaggaac gcgaactcgt
     1621 cccagccggg cagctcaccc tggatcggct ggccggggcg gaggaggagt ggcccggccg
     1681 ctacaagcac ctccggttcg tccaggagga cacgctgcgc gacgaggcgc ggcggttccg
     1741 ctccaccgcc cgccccggca tcccgaagag cggacggttg gcggcggtcg gcgtcttcgg
     1801 ccgcatcgtc gacgtcctgg tcaagttttc gctgctcatc cgcggcgccg tccccggagg
     1861 cctggccgcg gcggccgtca cccgctaccg cgagcaggtc gaccccggaa acgccaccta
     1921 ctacgggcgc gtggtccgcg atggcgacta catcgcgctg cagtactggt tcttctacgc
     1981 catgaacgac tggcgctcca tctacggcgg cgtcaacgac cacgaggccg actgggagaa
     2041 ggtcaccgtc tacgtcgtgg agacgcccga cggcgcggtg agacccgcct gggtcggcgc
     2101 ctcctcccac gagtacaccg gcgacgacct gcgacgcagc tgggacgacc ccgacctgaa
     2161 ccgcgaaaac gaccaccccg tcatctacgt cggcgccggt tcgcactccc accagatgct
     2221 tcccggcgac tacctcatcc aggtcgaccc cgccccactg cgcggtgtcg tgcgtgcctg
     2281 gcgcaacttc accgcccgcc tcttcccgca cacctcccaa cccggacgcc acggcatcgg
     2341 cgtccccttc gtcgactacg cgcgcggcga cggcgtgcgc gtgggccccg gcggcgaccg
     2401 cgaatgggac gccgtcctcg tcgacgacga caccccgtgg gtgcacggat tccgcgggct
     2461 gtgggggcgc gacacccgcg actggttcga cggggagcgc gcgcccagcg ggccccgcta
     2521 cgaacgcgac ggcaccgtcc gctactcctg ggccgacccg ctggcctggg tgggcctgca
     2581 gaaggtcgcc cccaccgatg ccgcggcccg cctcgaactc accgcgcacc tcaaagaact
     2641 caacacccgg atcgacgagg ccgacgacga gatcctcgaa cgccgcgacc ggctccgtcg
     2701 gctggcggcc gcccaatgcg tcctgcgccg cgacccgcac gcccatgctc ggacacgcga
     2761 gtacggcgac ctcatcgaga aggaggagcg cgagctcgcc gccctgtacc gcgagcgcgc
     2821 gctcaaggcc gacgagcgcg acgcccacgc caaggccctg gacagcgacg agcccgtcat
     2881 cgccggcccc acggcgcacc tgcgctcccc gcacctgccc tacgccaccg gggaccagcg
     2941 caccacccgc ttcgtgcaca tctgggtcgc gctgagcacc ccgctgctca tcaccgcgct
     3001 gggcgccatg ctcctgatgc acggccccta caccatcccg gtgatgatcg gcgtggtcct
     3061 gctgttcgcc gccttcgaca gcttcgcgcg ccgcaagctg cgcaccttcc tggccggact
     3121 ggccatactc gccctggtgg ccggagcggt caccggcatc atcctggcgt tcatggcgga
     3181 ctggcggatc accctgctgg tgccgatcat cgccgtggtg gcgggcctcc tcgtcgtcaa
     3241 cgtccgcgac ctcctgcggc gctgaccacg ctcggtcacc ggacattcgt cgcgggcagc
     3301 ccgtttggat cattgtgccg atttcgggcc ggtatcgccg tgccttttga cagactcagg
     3361 cgagagacgg gttccctcct gcggctgaat ccggaggtct ccacgcgagg ggatggggga
     3421 tgagcgtcgt cgacccggcc caggagacca gtgcgcgctc cgggccggac ccgagcgtcg
     3481 acgcgcgccc cgatcccgcc tccggcccgc gcgccgcccg actcgccggc cacgccgtgc
     3541 gggcgctggt cgaggaggcc gcgctcaccc ccaaaccggg gctggtcgat cgccgcggtg
     3601 gcggcgcgca ccccgacatg gacctgcgcc tgatggagcg ctccgccgag gcgctgcgcc
     3661 ccgccttcgc cctgatggcc gccgcatgcg acggccgcgc ccccgacgag gcgctgcgac
     3721 ggcggctcgg cgcgctgggc cgccgcgccg aagaggacat gctgaccgcc accggggcgt
     3781 gaacacccac cgcggcgcga tctgggcgct cgggctcctc gtctccgcga ccgccatgca
     3841 cgccgacggc gcccccgccc ccgagatcgc ccgcaccgcc ggccggatcg cccgcatccc
     3901 cgaccccgcg gtcaccggct atgccgcacc cacccacggc gcgcgggcgc tcgcccgcta
     3961 tggtctgcgt ggcgccaggg gtgaggccgc cgacggcttt cccacgctgg tgtcgcgcgt
     4021 cctgccggtg ctgcggatct cccgcgccgc cgggctggac gaggagcacg cccggatcaa
     4081 cgccctggtc ggcgcgcttg ccgtgctcga cgacacctgc ctggcccacc gcggcgggat
     4141 cgcggccctg cgggaggtgc agcgcatggc cgccgacgtg ctggaggccg gaggtacctc
     4201 caccaccagc gggtatgagc tgttcacccg gttggacgac acgctgcggc gcgacaggtt
     4261 gtccccgggc ggctcggccg acctgctggc gggggccctc ttcctggagc gggcaaccgg
     4321 accggaggcg accgcgccaa ccaaggcgga cgagagaggc gagatggagg acatcggcga
     4381 cccggcccgc acggtcggtc ccgtagcggc gcgcggcggc ggcgtgcggg aacgccgcgg
     4441 cgacgccctc gggtgacgtc tcgcccttcc cgggaacggg gcaccgttcc cgccggaccg
     4501 cccacgcact cttccgacgt cgaggtgatg gaccgcatga gacgcacgcc gatcgctggg
     4561 ggcacgccct acaccggcct gaccgcccgc gagcgtgccc gtgccctctt ggacccgggg
     4621 acgttccgcg agctcctcgg ccccgccgat cggctcgtct ccccgcacct ggcgccccag
     4681 ggcatcattc cccaggccga cgacggcgtg gtggtcgccc gcggcgcgat cgacggagcg
     4741 cccgccgtcg tgctgtcgct cgacggcacg ttcctcggcg gcgccatcgg cgaggtctgc
     4801 ggcgccaaga tcgccggtgc gctggagctg gcctcccgtg ccgccgcggc cggtggcacc
     4861 gtccgcaccg tcctgctcct ggagaccggc ggtatccgcc tgcaggagtc caacctgggg
     4921 ctgctcgccg tcgccgatat ccacgccgcc atcgtcgacc tgcgacgaca cgccccggtc
     4981 gtcggcgtca tcagcggcag gatcggctgc ttcggcggca tggccatcgc ggcggggctg
     5041 tgcacccggt tgatcatgac cgcgcaggga cggctcggcc tcaacggccc ccaggtcatc
     5101 gaggaggagg ccggggtgag cgaactcgac gcggccgacc gcgacctgat cctgcgcacc
     5161 gtcggcgggc ggcgacggac ggcggacgga ttcgccgacg cgctcgtcga cgacgacacg
     5221 ggggagatgc gcgcggcggt ccgttccgcc tgtgccgcca ccgcgcccga cgcgtccgcc
     5281 caccgcagcg cccgcgtcgc cgagttcacc gagcggctcg ccgggtgcgc gccgggcgag
     5341 gacgctcgcc ccgacaccgc cgcgggcccg gccgggaccg ccgacaccga agcggccgcc
     5401 aaggaccgcc gcggcggcgt ctggatcgcg gcgctgaccg gcgctccggt caccgcatcg
     5461 gccgagggcc cggcatcggt tctggcggcc gatggcgagc tggccggtcg cgcggcccga
     5521 ttcctggcgg tcgtccccga tcccgacgcg cgctggccgc gcgcccgcgc cggggaggtc
     5581 ggtctcgatg aggggctggc cctggccgca cgcgtccgcg cggcggtgcg ggccgacgcc
     5641 gcgcttccca ccgaggagaa gcgggccatc gtcgcgatcg tggacacccc cagccaggcc
     5701 tacggctacc gcgaggaagt gcacggcatc caccaggccc tggccgcggc cgtcgacgcc
     5761 tacgccggcg cccgccacgc cggacacccc gttgtcgcct tggtcgtcgg ccatgcgatc
     5821 tccggcggat tcctcgccca cggcctgcag gccgaccgca tcgtcgcgct cgacgaccct
     5881 gcggtggtga tccaggcgat gtcgaaggag tcgaccgccc gcctgacccg gcggaccctc
     5941 cccgagctcg acgcgatcgc tcgcgaggtc ccgtccaccg cctacgatgt gcgttccttc
     6001 gccgcgctgg gcgccgtgca ccggctcgtc accggtgtcg acggcgacgc ccccggcgcc
     6061 gacaccgtcg gaaccgccac ggtccgcgcg gccctggagg acgccgtcgc cgacgcgcgc
     6121 tccgcgcccg cgggtttgtc agtacggctg tgctcggccg aggcccggcg gaaccgcgcg
     6181 gcatccctgg atgtgcgccg ccgtctcgcc gagacatggg atcactgatg accgaaaatc
     6241 tcactctggc cacgtgaacg gtgctggggg tagcattcca ctcacgttgc gtcatctcgg
     6301 ggtcaagcgg aggtgaaaga ttcgtactgc gcgcggcgca ccctcgcagt ccggcgaacg
     6361 cggggagtgg gccgggcgac cgcggggcgg tgagatgggg catatcatca cgtccccctg
     6421 cattcgggat gaaccgtacc ggtgctgcgg cacgtgtgct gagtgacccg ctgacgcggg
     6481 gatggaccac gggggaggct atcgagtggt tggcgacgag cagctgggcg cgggatgtcg
     6541 gggcatggac cccgccgtat tctccggagc ccgcccgcac gatctgctcc gcttcgatga
     6601 cccgggcgcg gttctgcccg agggaccgga gctggagctg ccgatgtggg ccgtgtcggt
     6661 gctgcgcgat gtgccgtggg tggtggtgcg gcgcgggatc gccgcggccg ggcggatccc
     6721 ggtcggtatc cgcggtgtcc ggcgggccga ccgcgtcgcc gccttcctgc cggagtccgc
     6781 ggtcgtcgag cggttcaccc ccgaacaggc ggctcgctcg cacccgcgat tgcccgacga
     6841 gcgcaaggcg gccgtgcccg cgctcggtgc gctcacgcgg ctcgacatga tcctgcgccg
     6901 ccacgtcccc agctggggaa tcggcggcag cgccgggttc gagatcgtca ccggcctccc
     6961 cgtcaccctg cccggaagcg acctggacat cgtcatccgc ccccgcgaac cgctcccgct
     7021 actgcgggcg gcgacactgc tggcggacct gcgcgcgctc ccggtccgcg tcgatgtcca
     7081 gctgtgctcc accgaaggtg cgttcgccct ggtcgaatac gcgcgcggcg gcccggtgct
     7141 gctgcggccc ctggacggct ccccgccgca gatggtcgag gacccctggc cgtatcccgc
     7201 ggatccgacc tcgtcggccc gcgtgacacg accgcgggag ggaaggtaga acggaaaccg
     7261 gaacggacat cagtcgcacc ggggacatgg agcctcggag cggaacaatc ttcaccgcgc
     7321 tttccacgat cgccctgcgc gcaggggcgt aggacggtcg aatcgggagg agcgccgtca
     7381 acagagcggc gccgttcggg cctcgccttc ggtcggcgca cgcgatccgc atctggggag
     7441 gcggagggcc cggcagccca cgcgggatcc gctgggggcc gggtatctgg acattccgga
     7501 gagttcgggt gatacctacg ggtgggtatc actacgttcg ccccttttta ctctcgatga
     7561 cgagggacac ccgatggacg aatccggtac cgcccgagat cgagtcgacc gcagcgcgga
     7621 tctctccacc gcgccggggg gcggcacgcc cgtcatcccg actcagcagg ccgttccgat
     7681 gacaatcacc agggcggacg gagcgccatc cgggccgacg atcggcgcgg aggaggagtt
     7741 cttcgtcatc gacgccgcca cctaccaggc tcggtcgcgt gcccccgagg tgctgtcggg
     7801 cgcccgcacg cgatgttgcg gaggccgacg cggatccacg gtcagcgccg agatcaccca
     7861 ggtccaggtc gagaccgcga cacccgtgtg ccgaaccggc cgggaactct acggtcacct
     7921 ggtcgcggcc cgccagtccc tggccgaggc ggcacgcgat cacgggctgc acatcgccgc
     7981 taccggcacg gcggtgatcg gtgatgcggc ctgcgcaccg gtcaccgaga acgatcgcta
     8041 taccagaatc gtcgcgagct acggcgcgat gcgcgacgca cgcgccgtgt gcggctgcca
     8101 tatccacgtc ggcatcgccg accgggaaac ggccgtgcac gtcgccaacc acctgcgggc
     8161 ctgggcaccg gtgctcgtcg cactcggcgc caactccccg ttccgcctcg gccgcgatac
     8221 cgggcacgcg agctggcgcg cgatcgcctg ggcgatgcag ccctcggccg ggccgccccc
     8281 tgtgatgcgg tcggccgccg aatacgaccg tgccgtcgac gacatgctga tctccggcgc
     8341 gatgctggac cggcacatgg tctactggga cgtccggctc tccgcgcacc tgcccacggt
     8401 cgaactgcgc gcggtggacg cgacgagcac ggcggaggag gcggtgctga tcgcgctgct
     8461 ggtgcggggt ctgacagtgg tggccctgcg gcacgtggcc gatgggcggt cggcaccgga
     8521 gcccagcgac cagacgctgc ggctctcggt gtggcgttcg gcccacgacg ggctggaggg
     8581 cgaggccttc gaccccttcc gccgcgagct cgtccccgct cgccgtctcg cccaccagat
     8641 gctggagcag gcccagcagg gactggtgtc cgctgacgcc gacttcgccg gacggttgct
     8701 tgcccggctg ctggccgtgg ggtccggtgc ccaccggcag cgcgccgcct acgcccggcg
     8761 cgggcggctc accgatgtgg tggacctgct ggtccgtcag acgcgccacg gcctggcggc
     8821 cgtggagggc tgagcacgcg agcttcgggt cggccggacc gagagaaccg gacgcacgcc
     8881 cgtcgacggg gcggccctac tccagcccgg acgcgcggat ggtgatgttg agccgcccct
     8941 tcgccaagcc gacatccggg tcggcggtgc ccggcaggat gcgcggcacg ccgtggtagg
     9001 ccatccgcga cgggccgccg aacacgaaca ggtcgccgcc gcgcagttcc acgtcggtgt
     9061 aggggcgact gcggttttcg gtgttgccga agcggaagac gcacgcgtcg ccgaggttca
     9121 gcgagacgac cgggacatcg gcctgctcct cgcggtcctg gtgcatgccc atcttcgcgt
     9181 cggcgtcgta gtagttgacc agggcgacgt cgtagtcggg ggtgccggag gccaggggcg
     9241 cgccataggc atcggccacg cccgcgcggg cgagctcacc cagcagggac gggaacggcg
     9301 ccacgggctc accgtcgggc agcgtcctgg agtaccggta gggctcccag tgccagccca
     9361 gcgacaccat ccgcacgctc atcatgcccc cgcgcggcat ccggtgccgc cgcatcccag
     9421 cgggcccgcg cgaccactcg cggcacagtt cgacgagcct gcgctgggtc tccgtgctca
     9481 gccagccggg aacatgcacc gcgccggggg agacctccac gggctccgcc gggaccgcga
     9541 acagcgcatc gctcatgtgt tcactctgcc agcgcgacac atccggcgca cgtcgccgcc
     9601 atgtgcctgg tgacatggat ggagggacat cggcggggca cgggtgctcg gcacccgcgc
     9661 cccggatgtg ggccgtcggt gcgcgcaccg actagtcgca cagtagcgcg cttaactgac
     9721 ttagcccgcc gcaggtgatc acgctgagcc gactctcctg catgggctgg tcaccattct
     9781 cggtaacagg accttccatc gactgcaggt caagaatgta ggacatggtg atccactccg
     9841 ttctgccggg ggcgtccccg acgctgtcgg gtgttaaggg gccgggagaa cccgggcccg
     9901 agatggtgct ttggttcgat gtggccggtg cgctgatcgc cgccgagccc ggggcggatg
     9961 ctcctttcct tgacggggat ggtcgggtct cgggggtgcc ttacccgtcg ggggaacggg
    10021 cggcgcgcgt gaggaagggg aggatcggga cacggtcgtc gcggaccgtg gccagcgcga
    10081 ggaggattcc ggcgctgccg gtcgcgaggt ccatcgagag ccgtagcagc tggtcgccag
    10141 ggaaggcgat ctcgccacgc aggccgacca tgtgccagcg cagccggtcg cgtttcatcg
    10201 ctatgagctc ctccagccgc tcgtcgcgcg tctccggccg ccgcaggtgg gtgagaaggc
    10261 cgagcaatcc ggcgttgccc tggaagagca tcgggaacac ggccaactca ggctctgccg
    10321 cgcggcggat ccgcgccagg gcagttgtga aggttggatt gtcccggtgt cgcaggaact
    10381 catcgatgac caagccgatg ccagccgagc cgtcggcgac atagggcatg gtgcggtgcc
    10441 cttcgtcgac gcccagggtg tcgtcggcct cattgtgggc acaggcgcgc aggtcctgtt
    10501 ccagggcctg ttgcgccaag tcgaggtatc cgtggtcgcc cgtctcccgg tgcaggtgga
    10561 taaagagcag tgcgctgccg gagggacctc gaatcagtcc ggccggtccc cgaccgccgc
    10621 gcttgtgccc cgcaccgtgc gccggtcctt gggcgagccg gtccgcgagc aactgtgcgt
    10681 cgttcactgc cgtgtcgagc agactgcggt cgccgagccg acgaaagaag tgcagccgat
    10741 tgagcgcgat cccgctgagc ccgctgaaga gaccatcggc cagggtcgtc ctgtcctcgc
    10801 cgtgggctgc tgtctctagt gtttcgaggg cttcgtctcg gaggccgatc ttctccaggg
    10861 cgtaggcgat gccgtgcagg ccgtcgtaga agccgagccg gtgcggggga cgctgcgcgc
    10921 ggacgcggcg cactatccac tccacccagg tcttccattc ctccggctcg gtgtggcggc
    10981 tgtgtccaga gacagagagg gcataaagta ctccggcggc gccgtgggcc aggccgagcc
    11041 cggaggtggt gaactgctcg acgtcgccgg ggaagaggcg gtcggtgcgc tcagcagtgg
    11101 aactcgctcg gatggcacga gcgatggagg cctcgatcgc tggccagtca gggcgctccg
    11161 gctcctccgg tctccgctca cgcggatgtg gtcgtcggtg accttcaccc gaaatgaggg
    11221 cggcggagcg cgccatctgc tccggcattc cggcccaggg agaggggccg acgtcgaggt
    11281 cggcgagcac gtcccggccc caggtggcgg ggacgggaaa gagttcctca acggtctcga
    11341 ccagtgtccg tgccttgccc gtgtcgagcg cgcacagcat ggtcagcggc aggaacggtg
    11401 cgatcttcac gcagcccagc gcatagcggt ccgtcgcgaa ggccccgcgg cggtcaggcg
    11461 gtgtgaaggc gggggcaccg aggccgatgc gcgcgccctc ttcccctcgg gtcgcgagtt
    11521 cgaagtcggc gagggcgatg cggccgtcgt cgcggagcag cacgttgccg ggatggaggt
    11581 caccgaacgc gatgccccgc tcgtgcagct gctcgaccgc tcgctcgacc tgtgcggtga
    11641 tgtccagggc ccagcgcgtg aagtcggcct tcgcggccga gtcgggttcg gggcggataa
    11701 gcgggtggcg tcggacgact tcgctgttga gggtgccccc ctgtgcgtac tcctggacga
    11761 ggaactcgtg ttcccagacc gtgaaccgtc cgtgaacgtc gatgaccacg tcgatgtcgg
    11821 cgagttcggt cagcatgtcg tactcgtgcc gcagccgtgt gatggcgtcg cgaccggccg
    11881 gatcgagcgc cgcgtgcggg cgtgcctcct tgaggacgac cttcgtgccg ctcttttggt
    11941 cgtcagctag gtagatgccg ccgccgttgg agaagtgcag agccgagcgg atcacgtaag
    12001 ggaaatccgc gggcggttcg ctgtcgcgcc gttcttccag gagggggcgg aggaattccg
    12061 gcggatctac ccagtcgggg caggagaaca ccggagcgcg gcggtccgga cagagccgcc
    12121 cttcggggtc ctcgatcgcc ggaaccgatt caccccattc attccggacg tgccggaatt
    12181 ggaaaccgcc gtatcggacg tagagcgggc cgtctttcca gcggagatcg ctgaggatgt
    12241 aggggccgcc gagtccgtgc agtctcgggg agagttcgtt aagtgcggcg tgcagctcaa
    12301 cgtccgatgg tgggtagata gtaatgaatt tgccactccc ggaacggtcg gcgtacttgt
    12361 ggttctgtgc gaggaaagct ccttcatggg ccaggaactt gaaggaaatt ccagtggaga
    12421 aacagtagtc cgacgtgatg tccaggacct tctgtggaga ttccaggttc gctgagacgt
    12481 ggatcttcca gccttggggt gggagctcgt cgtcctgtcg aatgtagtgg atccacggat
    12541 attcggcgct gatcgaccac gattcgttac tgggagtcgg ggggcaggtg taaggggtgc
    12601 aatctgtctt tcgattgcca ggatcgtcgt agaagagacg atcgtcgaga cagtactgga
    12661 aatagtcgag cttcattgtc cacccgcggg ggaagcaccg tgcgatcggc tggccttaat
    12721 aaagtctagt tgtttgaaat cttgtgtcaa gggtggaatt aaatcatccg tttggccgca
    12781 ttcggccact ttggaatcgg gggaatggtg gtgcaatgtt attttgtggc ggaaaatggc
    12841 aatataagat gaagttaatc cggatttata cttctcgccg tgtcgttctg tatgtattct
    12901 tgaaatatgt tgccacttcg gcgaaatgcc atgtttcgac ataatggtgg gggcgcgggt
    12961 gccgcgcacc cgcacccccg gaaggtgtgg atcggctccg tgagcggacg cgttcttcgc
    13021 acggtggctc aggagccgtg gttccccctg atcagcacag caggaggctg aggtagctca
    13081 cgctgtaggc ctggtcggcg ctctcggcga caggcgtttc catggactgc aggtcgagga
    13141 tgtaggacat ggtgaatcct ttcgttcggc cggagaactc ccggcctggt gtcagtccgt
    13201 cggtcggatt cgggtcgggg atagggaccc gaggtggtga atggttcact gcggcgtggg
    13261 cgctgtgtgc cgtcgcgccc gggtcgggtg ctcctttcgt cggcggtggt cggtcgggtc
    13321 ctacggggcg ggtgctaccg ggtggaggtg gcggtggctc gggtgaggaa gggcaggatc
    13381 gggaggtggt cgtcgcggac cgcggctagg gcgaggagga ttcccgcgct gccggtggcg
    13441 aggtccatcg agagccggag cagttggtcg ccggggaagg cgatctcgcc gcgcaggccg
    13501 accatgtgcc agcgcagtcg gtcgcgcttg gcggtgatga gctcctccag gtgggcgtcg
    13561 tgcccgtcgg cccgccggag gtgggtgagg aggccgagca gcccggcgtt gccctggaag
    13621 agcatcggga agatgcccag ctcgggttgg gccgcccggc ggatccgggc cacggccgcg
    13681 gtgaacgggg gatggtcgcg gtgtcgcagg aactcgtcga gcaccagccc gatcccggcc
    13741 gacccgtcgg ccacgtaggg cagggtccgc tgcccgtcgt cgacgagcag ggtgtcgtcg
    13801 cgttcgaggc ggacgcaaga gcgcaggtcc cgctccaggg cctggtgcgc caggtcgagg
    13861 tatccgtggt cgccggtctc ccggtacagg tgaacgaaga gcagggcact gcccgagggg
    13921 ccgcgcaaca gccccgctgc ctcgcgcgcg ccccgcgcag cggggtctgt cagccggtcg
    13981 gcgagccgct gggcgtggtt caccgcggcg tcgaggaggc tgcggtcgcc gagtcggcgg
    14041 aagaagtgca gccggttgag cgcgatgccg ctcctcccgc cgaagagacc gtcggccagg
    14101 gcgtcgtgct cctcgtcggg ggcggccgtc tccagtgttt cgagcgcttc gtcgcggagg
    14161 ccgatctcct ccagcgcgta ggcgatgccg tggaggccgt cgtagaagcc gagccggtgc
    14221 ggcgtgcgct gctcgcgcac gcggcgcagc agccatccct cccacatgtc ccacacctcc
    14281 ggcccggcgt ggcggccgtg cccggaggcg gccagggcgt agagcacccc ggcggcgccg
    14341 tgggccaggc cgagcgcgga ggtggtgaac tgctcgacgt cgccggggaa gaggcggtcg
    14401 gggcgctcgg gggtggcact ctcgcgtatg gcgcgggcga tggaggcctc gatcgcgagc
    14461 cagtcggggc gtccggatgc cgagggcctt cggtcgtccc cctggtcggg gcgccggtgc
    14521 tccgcgcccg tgatgagggc ggtggagcgt gccatctgct cctcggtgcc ggcccaggga
    14581 gaggggccga ggtcgaggtc ggcgagcaca tcccggcccc agccggcggg gacggggaag
    14641 agatcctcga cggcgtccac caggctccgc gcggtgccgg tgtcgagcgc gcacagcatg
    14701 gtcaggggga ggaacggtgc gatcttcacg cagcccagcg cgtagcgatc ggccgcgtag
    14761 gcgccgcggc ggtcgggcgg ggtgaacgcg ggggcgccga tgccgatgtg cccgtcctcg
    14821 tcaccgcggg tcgccacctc gaagtcggcg agggcgatgc ggccgtcgtc gcggagcagc
    14881 acgttgccgg ggtggaggtc gccgaaggcg atgccccggt cgtggagccg ctcgatcgcc
    14941 cgctcgacct gtgcggtgat gtccagggcc cagcgcgtga agtcggcctt cgccgccgtg
    15001 tcgggatcag ggcgagccag gggattgcgc cgtgccatct ccgtgctgag ggtgccgccc
    15061 ccgacgtact cctggacgag gaactcgtgc tcccacgcgg tgaaccggcc gtggaggccg
    15121 acgaccgcgt cgacgtcggc gagctgggtg aggatgtcgt actcgtgccg cagccgggcg
    15181 atggcgtcgc ggccgtcctg gtcgagcgcc gcgtgcgggc gcgcctcctt cagcaccacc
    15241 tgcgcgccgc tcgcgcggtc ctcggccagg tagatcccgc cgccgttgga gaagtgcagg
    15301 gcggagcgga tcacgaaggg gaagtcggcg ggcggcccac tggcgctccg ctcttccagg
    15361 agcgggcgga ggaagtgcgg cgggcgcacc cagtcgggga aggagaagac agggtcgcgg
    15421 cgatcgggac ataaccgccc tagcgggtcc tcaatcgcag gaaccggctc acctcgttca
    15481 tttcggacat atcgaattgt gaaggcgccg tagcggacat agagcggact gtctttccag
    15541 cggagatcgc tgaggatgta gggcccgccg agtccgtcca accgttcgga aagttcattg
    15601 aggatggcat gcagctcgtc atccgacgcg gggtagatgg tgatgaattt cccactcgcg
    15661 gagcggtcgg cgtacttcgc gttccgcgcc aggaaaactc cctcgtggga cagaaacttg
    15721 aaggatatgc ccgccgatag gcagtactcc gacgtgatgt ccagtacctt ctgcgccgat
    15781 ttcaggttcg ccgatacgtg gaccttccag ccctggggtg ggggctggcg atcctgccgc
    15841 atgcggtgga tccacgtgcc gtcatcgctc gtcgaccatg atctaccggc aggaggtgcg
    15901 gggcaggtgt agggggatcg gtccgcttct cggcttccgg gggcgtcata gaagagacgg
    15961 tcggcaaggc agtactggaa atagtgtaat ttcattgtcc gcccgctgtc gggtttgctg
    16021 ggcgtgatcg cgcaacaaca ccgaagcgta cttgtccgaa gtcgggtgtc aagaccgaat
    16081 tggcgggcgg agcatgaccg catccggtca ccgcgttccc ggttggaatg ggaaacggta
    16141 ctgttcccat tcgttttctc ggctgtgagc tgcggcggtc cggtccgaat gctattcggt
    16201 gttgcggccg gttccctgtc tcatgtcggg gtggccgtgg gtgcttttgt tgaaagctat
    16261 ttatatttca atgaacatcg tcattggaga tcatggacaa tgcgaaggat tccgtcgccc
    16321 cagtgagccg ctccacgccc acccgcacac caccccaccg ccaccgcgtc acgtctgtgc
    16381 cgtcgacgcc tccgccgcct gttcttgctc cacccatgcc gtcagtgagc gcccctggac
    16441 ggccgccgcc atcagttcgg ggaaccggtc gggcgtgcac gcgaacgccg ggaccccgag
    16501 cgcggccagc gccgccgcgt tctggcggtc ataggacggc gccccctcgt ccgacagcgc
    16561 cagcagcacc acgacctgca ccccggccgc cgtcatggcc gcgacccgac gcagcatctc
    16621 ctcccgcaca ccgccctcgt acaggtcgct gatcagcacg aagatcgaat gggagggccg
    16681 ggtgatgagc tcctggcagt aggcgatggc ccggttgata tcggtgccgc cgccgagcgt
    16741 cgtgccgaac agcacctcca ccgggtcgct caaccggtcc gtcagatcga cgaccgatgt
    16801 gtcgaacacg accatcgacg tactcagggt ccgcatcgac gccaggaccg caccgaacac
    16861 acccgcgtac accaccgacg ccgccatcga cccgctctgg tcgatcgcca gcacgacatc
    16921 gcgttccacc ccccggctcc gccgcccgta cccgacgagc cgttccggga ccaccgtgcg
    16981 ccgctctggc agatagttct tgaggttggc gcggatggtg cggttccagt cgatgtcggc
    17041 cacccgccgc gggcggtggg tgcgcgccga ccggtccagc gccccctgca ccaccgaacg
    17101 cgtgtgctgg gccaaccgcc gctccaggtc ctccacgacg gagcggacca ccgcccgcgc
    17161 cgactcgcgg gcctgctccg gcatgacccg gctgagcgag agcagcgtgc cgaccatgtg
    17221 cacgtccggc tccaccgcct ccagcatctc cggctccagc agcatccgct ccagcccgag
    17281 ccggtcgacc gcgtcggcct gcatcacccg caccacgctg gaggggaagt aggaccgcac
    17341 atcgcccagc caccgcgcca cccgcggcgc cgagccaccc agcccgccct ggcgggagcc
    17401 gtcgcgggcg ccgtccgatc cccggtcgta cagcgcggcc agcgcaccgt ccattccggt
    17461 gtcagccgcc cccagtccgc cacaggcctc cgcggccggt tcccccagca ccaaccgcca
    17521 ccgccgcgcc cgctccggcc ccggcgcctc gaactcgtcc atcgtgtccc ttcctcggtt
    17581 ggtcaccggc cgcgtgccgg gcggccggtc acgggtcgtt gtcgttcagg tctgaggtgc
    17641 tgtccctccg ttgatctcgg ggatattggg gtaaaaactg ccgctgaaac cccaatatct
    17701 ccgagatcaa cggagggaca gcgacttcct tggtggaacg tcagtggccc gtgcgggcta
    17761 gggctttctc cggcaggccc agcagggtcg ccaccgtggc gacggcaggc gccgcgcggg
    17821 ccgtgtcgat gtcgtcaggc gtcgcctcgg cggtcgaccg cccacggccg agccccctcg
    17881 cccgctcgcc gatcgaacgg cgctccgccg ccggaaacgc cccgaacgtg cggcggagca
    17941 gcggcagcac ctcggtgaag gcctgctcgc ccagcccggt cagccagcgg tcgatcagcg
    18001 acagcagcgc cgtgtcgtgc acgagcagca gcccgctgcc cgacaggaag ccctcgatcc
    18061 aggccgccgc ccgctccggc gggaccgcgc gcgacgtggc cttggcgagg cgggcggcca
    18121 gctccgtgtc ggccagccgg cccgcgtcgt acagaatccg gtgcgcccgt ccgcccacgc
    18181 ggcccgggat gtcctcccgg ccggccaccc ccgccagcgc gtccgcccac tcccgctcgg
    18241 cgaccccgcc cagcagcacc gccgccgcgt ggacgtcgtc gacaccgcgc accatgcgcc
    18301 ccgccgcgtc gtcccccagc ccggacagcg cgggaccgag ccccgcgcac acccgcgcca
    18361 acagctgctc ggccacgcgc cgcagcgcct cggagtccag acggcgcaca tcgccgtagc
    18421 gcgcggaccg ggccaacggg ggaagcgccg ccatcaggtg ctcgatatcg gtgtcctcgg
    18481 cggcccccgc cgccagcgcg gcgagcacat ccccgatcgc gtcgggcaga tcagcgagca
    18541 ggcactgctc ggtgatccgg gtcaaccggg gcaggtcggc gccgcgcgtc aggtccaggg
    18601 cgcgcgcccc ggcggcggac gccacgtccg tgccccaccg cgctgcctcg atcagcgcga
    18661 tgtcgagctc cggcgtccac ctcagcgtcc aggactcgcg gaacgttccg cgcgaccggg
    18721 gggcgtcgcc gcgcggcgtc ccccagtcca ccccgatgag ccgcagccgg tgcagcagga
    18781 cgctgcgctg gcgcacgcgc tcctcgcgca gatccaggtc gaggtcgcgc tcgaccgcct
    18841 ccggcttgag ccggagccgc cgctgctggg cgaccaggtc ccgctggagc ggcaccatcg
    18901 gtgtcgcttc ggggaccgtg ccgaggcgct cgccgatgac catcgaccgg tgcaccagat
    18961 ccgcgcgcag ttcggagccc tcgcacagca ccgccgaggt cgcctcggcg agctcgtcca
    19021 accccggcag gggacggccg cgcagcgcgg ccaaggagtc actcagccgc accgcctcga
    19081 tgacgtgcgc ggaggacacc ggctggtcct cggcgcgcag ccgctcggcg gcctcggcga
    19141 gccaccgctc caccgggcgg tccggtgcgg tgaacaggtg gtggtaccag ccaggcgagc
    19201 gcacgcccgc ccggtaaccg gacgccgcgg cgaggcggcc gtgcgtccac ggaatccatg
    19261 tcgccgccgc cttcaccttg ggcagtcccc gcagcagtgc gttgtcgtcg gcgacccggg
    19321 ggtggtcgag cagtgcgggg gcatgccagg cgccgcagac caccgcgatc cgggcgtacc
    19381 cggcccgcat cgtcgcgcgc aggaccttgc gcatgtgcgc ctcgcgccgc gcctcacgct
    19441 catcctccgg ctcgggcgcg agctcggcgc gtaccgccgc catggcctcg gcgatcgccg
    19501 ggaagggcga gggagcgtcc gccccggccg cgccgcgctg ctcgacgacg tcgtcccacc
    19561 agcgctccgg gtcgtcgtac ccggcggcct cggcgaggac gccgagcggg tcgacacggc
    19621 tccgccgcgc cgccgccgac gcctcgtcct cctccggagc gtcaccccgc cccggtgtgt
    19681 ccggcccctc cggtccaccg gcccctgcgg cgtcgccttc ggccagcgtg tgggcggcgg
    19741 gcagatcgca gaaccgcacc tcggtaccgt gctcggcggc gtagcgcagc gccacccact
    19801 ccggggagaa cgacgcgaac ggccagtacg ccgcccgcgc cggggcatcg ggcacgtagg
    19861 ccagcagtga caccggcggt tccagctcgc cgaccagccc ggtcagcccg tcggcctccg
    19921 gagggccctc gatcaggacc gcgtcgggcc cgatctcctc caacgccgcc cgcaccgccc
    19981 gggccgaccc ggggccgtgg tggcgcacgc ccaggacgtg cacgcggtcg gtgtccacgc
    20041 gcgccatcag cggcccgtct cgcggcaggc ccggtagaag tcctgccagc cgtcgcgctc
    20101 gcgcaccacc gtctccaggt attcgcgcca caccacgccg tcggagacgg ggtcctgcac
    20161 gaccgcgccg tggataccgg ccgccacatc ggccgggcgc agcgtgccat cgccgaagtg
    20221 cgcggccagc gccatgccgt tggtcaccac ggaaatggcc tcggccgtac tgagtgtccc
    20281 gctgggcgac ttcaccttgc tctgaccgtc ctcggtgacg ccgccgcgca gctcgcggaa
    20341 gacggtgacg atgcgccgga tctctgtcat cccggccggg acctcgggca gttccaggga
    20401 gcgtccgagg tcggcgacgc gccgggtgat gatgtccacc tcctcctcga cagtgcgcgg
    20461 cacgggcagc accaccgtgt tgaagcggcg gcgcagcgcg ctggacaggt cgttgacgcc
    20521 gcggtcgcgg tcgttggcgg tggcgatgat gttgaagccg cgccgtgcct gcacctcggt
    20581 tcccagctcg gggacgggca gggttttctc cgagaggacg gtgatgaggg cgtcttggac
    20641 gtcggaggga atgcgggtga gctcctcgac gcgggccaga cggccctcgg ccatcgcggt
    20701 catcaccggg ctcggcacca tcgccgcctc ggagggtccc tcggcgagca ggcgggcgta
    20761 gttccacccg tagcggatgg cctcctcggc ggtaccggcc gtgccttgga cgagcagggt
    20821 ggagtcgccc gcgatcgccg ccgccaggtg ctccgacaac caggtcttgg cggtgcccgg
    20881 aacgccgagc agcagcagcg cgcggtcggt ggccagggtc gccacggcga cctccaccac
    20941 gcggcgggca ccgatgtact tggggctgat caccgtgccg tcatcgagcg tgccgccgag
    21001 gatgtagcgg gtcacggccc agggcgacag ccgccagccg ggcgggcggg gccggtcgtc
    21061 ggccgtggcg agcgcggcga gttcgtcggc gtagttctgc tccgcgtgcg gacgaagggg
    21121 ggccgtgggg gcggaactgc tcaattgagc tcctcatgca tctcgtagcg gaatcggagt
    21181 gtggcggcga gccgggccag ggtgcgcccc ttccggtcgt cgccggactc gggggagtcg
    21241 gcggaggtgg agccggtgcc ctccccggcg tcggccgggg cgccgtactc cgcgaagcgg
    21301 gtgtggaggg tgggcagaag ccaccgctcg gccgcggcgg ccagctgggt gtaggccgag
    21361 gtcgtccgtt cggccccggc cttggtgccg agcagtgtgt cgaccacgat cgcgccgagc
    21421 tcctcggtcc agggacagtc cagctgctcc acgatgttca gcaggtggga ggcggaagcg
    21481 cggtcggcgc gcgcctgccg cacggcccag gcgcactgct cggcggcggg cagcagggcg
    21541 aggagcgcgg ggccgcggct gccgcgcagg tcgtgaccgc gggtgaggcg gtccagaacg
    21601 gtcggcagga gcagccgcgc ccagtccaga tcgcgctgca cgaccgcggc gttggccagc
    21661 gcgtcggcga ggtcgccgga gccggagacc tcgcgcacga cctcggcgcg gtcggtgccg
    21721 aggtgtccca cccaggtgtc gagcggggtg tgcgagatca gcgtccacag ccactcgcgc
    21781 cggatctcct tgcgcggatc gccgtcggcg ggggcggtga cgttgaggtc gcgggcgagt
    21841 tcggtgtcgg cgaggtcggg aagccggacg gacagccgcc cgtgctcgcc gggcaggaca
    21901 tggcggcggg cgtgggcggc gaggtggcgg ccgtgcgcgg tgtcgggcaa ccgggccagc
    21961 aacgccatgg cgagggcgcg cacgcgcgtg ctgcggtcgg tgagcgcctc ggtgagcagg
    22021 ggctcgtcgg cgggggagag gcggtcgtcc agggactcca ggagcgcccg gcgccgctcg
    22081 accgactccc gccgccactc gtcggcggtg aactccccgg gcggcaccag gcgctccagg
    22141 taggaccagt cggggttgag ccgggcgagc caccgcccgc gctctccgga gaccgccagg
    22201 accagccgcc cgaacgcgtg gtcgcgggcg ccgcgctcca gcaggtcggg cagggcctcc
    22261 ggggggacgc gcagtcccct gtcggcgacc agggcgagcc actcgcgcag ctgggagcgc
    22321 gttccgcact ggtcaaccgg tccaaccgcc gagcggcggc cgcgctgacc gccggccgcg
    22381 tctccggggg cgcgggctcc agcgccgcaa cacgtgcggg gcaccgcccc gcacggtcgc
    22441 gcacggccac cagcgccgcg tggtcgagca gcgccagcgc gggatcgtcg gcggtggacg
    22501 ccgggacccc cgacgcgccg ggcaccgccc gccgcgcggt accgaccagg gccgtggaga
    22561 cgagctccgg ccaggtattc gtcatgggca caggtcgtgg tcctccagct tgatccgggt
    22621 ggtcgcggga tggtcgttcg ggcaccggcc ccgggcgggg cggcgccgga ctccgtccga
    22681 cgcggacggc gcggccgtca accgcggcgc ggggcggatg ggggaggcgc cggtcggccg
    22741 tcccgccctc gggcgcggtc gcgactgtgc cgccgggggc ggagatcggc gatcccacga
    22801 cgcgcggtgg cgccgcgtac taggccgtgt ttttcgaatc atttcgggct cgcggccacc
    22861 ggaacgacgc tcgctgcgcc gctccactcg ccaagccgac ctggattgac ttcgtgaagc
    22921 ggcttgcgag cgccgccccg gacggccgct cgctgatccg aaagcattca aaaaacacgg
    22981 cctaggcgac gaccggaccg acatagcatc ctcctcgcag gccagggggg agacgggccg
    23041 gctcaccccg gtcggtggtg atggcgcgtc acctgatcgt tcgccgaacg tgggagctgg
    23101 gagtcccgtc gccgacgcag caggggagag ggacagccgt caggggtcac atcggaacag
    23161 cgcgcccctc ggcggtccag gcggtgagag ggcgcaggcc gctgggggtc cactcggccg
    23221 ccacagtgag gggtgcgccg ccggagacgg cggcgagccg ccagggctgg gacggggcca
    23281 cggcccggtg cacggggagc gccgcccccg acgggtccgt gagccaccag ccgtcccggt
    23341 gtgcgacggc ggcgtcgcgg accaccaccg gccactcctc cagccagggg tcggcggcca
    23401 cggcggacgc ccacgacttc agggcgtcat ccaggcttcc accgggcggc gggtcggcgc
    23461 ggtgttcggc gtgccgggcc accagggagg cgcgccgctc ggccgggtag aaggccagat
    23521 cggcctcgaa ctcggtgccg acgcgcgccg cggtttccgg ggttcgaccc gtgggggcga
    23581 acgagaccag catggcgacg cgttcggtag cgcgcccacg cagccagatc ctgcgtcccc
    23641 gcacctgccc ggccggaaag tcgcgccgcc ccagcacctg ccaggtatcg cgcacggggg
    23701 cgctctcgtc cggcgcggtg accagcccgg cccgggcacg cacggtcgcc cgcagcggct
    23761 cgggcaggtc gtcgcggcgg cggtaggcgg tgatgaggag ccggagcagg gcgaactccg
    23821 tcagcagccg accgggccac tcgtccttcg cgcacacgct tcccagctcg cggacgcgat
    23881 cggccacgcg cccggcctgg gcgtcgacca accgggcggc catgccgtcc cagtggccgt
    23941 agtcgcgccc cggcgcaccc gccaacccgg cctgtgcctg gtcacgcagc cacaactcca
    24001 gctccgcgaa cccctcggcg acgcgctcct cccgccgctg ggtacggcga gcggccgcct
    24061 cagcatcggg cgcggcatcg cgccgctccg tcgtcgcgtc gcgccggatc aaccagtcgg
    24121 cgacccagtc cgggggatcg cccgccgcct cgacacggcc ctccacccac aggtggagca
    24181 gcgccagggc gtgcttgcag gggaacttgc ggctgggaca gctgcacttg gaggccgggg
    24241 ccgatggccc ggtcaggtgg acggcggtct gatagggctt cttgccactt cccgcacacg
    24301 cgccccacag cgccacggtc ccacccgggg catccgcggc ctccgtgggg tcggcggcca
    24361 ggcggccgag tacgggccag gaggcggtcc gcgccacctt cacagcagcc ttccgcgagg
    24421 acgcgtcagg ggccagagcc gcgacgtcgt cggtgttcca acgttcgctc acatccccga
    24481 acctaggccc ggggtaggac atttccgggg gctcggcgat cttcgcggcg cgggcgtccg
    24541 gccgcacacc gcatccccct cgggaaggac gcgcaccacg gcacgtccac ccgtcatccg
    24601 gggcttcccg tgtgagaatc ggcctacgga gcgctacggt tgcggtggcg acgatcacga
    24661 ttgggggatc cgatggtcgg gggagagacc gagggcaggg atctgctgcg gctgctggcc
    24721 gggccctggt tgaccgaggc cgccgtcacg gccgtgcggc tcggcgtgat cgaccggctc
    24781 ggcgacgggc cggagacccc cgccgaaacc gccgcggcgc tgtccctgag tcccgagccg
    24841 ctggcgcggg tgctgcgcct gctcaccgcc gcgggcgtgc tgagcgagga gggcggacgc
    24901 tacgccctga cggagatggg cgagcagctg cacagcgacc accccgcctc gatgcggccc
    24961 ctggcgctcc tgtacaacag cgacttcttc acccgcgcct ggcgggggct gagcgatgcg
    25021 gtgcgcaccg gggagcccgc cttccccgcc gtgcaccacc agggcatcta cccctacctc
    25081 gccgaccatc ccgacgacga ggccctgttc gacgccggga tggccgccgg cagctcgttc
    25141 gccaccgggc tgcccgccgc ctacgacttc tccaccgcca agaaggtcgt ggacgtggga
    25201 ggcggcgacg gcaccctgct ggccgccgta ctgcgcgcct acccccacct gcacggggtc
    25261 ctcttcgagc ggccgcccgc gctgcacggg gcgcgcgaac ggctcggccc cctcatcgcc
    25321 gaaggccggt gcgacctggt cgagggcgat ttcatgcgcg agatccccgg cgacggcgac
    25381 atctacatcc tgtgccgtgt cctgcacaac tgggacgacg aggcctgcca cctgctgctg
    25441 ggcaactgcc gcgccgcgat ggggccggac gcgcggctgc tggtggtcga gcgggtcatc
    25501 cccgacgggc ggcaccccct gctcaccctc gccttcgacg tgcacatgat ggtgatgacc
    25561 agcggccggg agcgtaccgc gagcgagtac gaggccctcc tgcgcccgga gggactgacc
    25621 accgctgaca tcacggacct cgcggccgag atgcggctgc tcatcgcccg cccccgctga
    25681 gcgccccgcg cggcacgccc ggcccacggc gaccaccgcc cgacatcacc accccaatac
    25741 cccgcatgac cgggactttc ggcactcccc tcgcagcgcc ccgcgactag cgttgagctc
    25801 gcaccgacaa aaggaggagg ccatggccgg gcacaccacg acgccgatcg tggcggcggt
    25861 ggacggcggg aagtccgccg cacgagccgc tgactgggcc gccgacgagg ctcagcggca
    25921 gcggcgcccg ctgcacatcg tgcacgccaa cgagtggccg atgtttcact cctcgctcgg
    25981 ccccgccgcc gagga
//
