LOCUS       NZ_CP022753            21206 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Nocardiopsis gilva YIM 90087 chromosome, complete genome.
ACCESSION   NZ_CP022753
VERSION     NZ_CP022753.1
KEYWORDS    RefSeq.
SOURCE      Nocardiopsis gilva YIM 90087
  ORGANISM  Nocardiopsis gilva YIM 90087
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     The complete genome sequence of Nocardiopsis gilva YIM 90087
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2017) Yunnan University, School of Medicine, 2
            North Cui Hu Road, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 208.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002263495.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 21:04:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,549
            CDSs (total)                      :: 5,470
            Genes (coding)                    :: 5,345
            CDSs (with protein)               :: 5,345
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 61 of 125
            Pseudo Genes (incomplete)         :: 66 of 125
            Pseudo Genes (internal stop)      :: 5 of 125
            Pseudo Genes (multiple problems)  :: 6 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1532519
            Orig. end                         :: 1553725
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21206
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="10"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21206
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21206
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11206](-)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11206)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     misc_feature    180..196
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.52"
                     /tool="antismash"
     gene            complement(474..668)
                     /locus_tag="CDO52_RS07175"
                     /old_locus_tag="CDO52_07160"
     CDS             complement(474..668)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_07160"
                     /product="hypothetical protein"
                     /protein_id="WP_026126045.1"
                     /transl_table=11
                     /translation="MRDAATRIVVGIGEDSTGQLCDRTSRALAAALGSAPVFFPGGHVG
                     FTEQPDTFAARLREFLHRD"
     gene            complement(661..921)
                     /locus_tag="CDO52_RS07180"
                     /old_locus_tag="CDO52_07165"
     CDS             complement(661..921)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_07165"
                     /product="hypothetical protein"
                     /protein_id="WP_026126046.1"
                     /transl_table=11
                     /translation="MIAHEPPLYNMLDDHDELIAASEDMIDTYVSGDALGAWRTFMDIA
                     GLPMPEEVFQQMFGQRTEKEAAEDRRFFLHTMRQPRPRPFA"
     gene            1444..2457
                     /locus_tag="CDO52_RS07185"
                     /old_locus_tag="CDO52_07170"
     CDS             1444..2457
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024824.5"
                     /locus_tag="CDO52_RS07185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07170"
                     /product="SEC-C metal-binding domain-containing protein"
                     /protein_id="WP_157745476.1"
                     /transl_table=11
                     /translation="MPTPDPQDMSAVTGEGEDELLSRVMRLSLGRGVEYVLRNYPDDTV
                     EFLLETARDLISKGQCERAMAVYEAVIAAPPSEADAQDAMVERIDLLLEQGDTAAADEA
                     IGELSKRGPMEMPAVLLAESLEARERLEDALTWFNSACRRGLRQVPEDAVRNLLDLGAL
                     RGRARVRSALGLAEDEFDVAVWTQYGESRMGGRERLVESAAGQEALPQGTISACFTRSS
                     FDRARREGLLYGEEAERAGDDPDAYYLAAERAVRRLAEEHPDVKVYFAVHSVEDLVAYA
                     AENGRDHAAPETRNAFVETLREDDPRIIAWPPRRNEACWCGAGRKYKKCCGSPSKR"
     gene            complement(2496..2639)
                     /locus_tag="CDO52_RS07190"
                     /old_locus_tag="CDO52_07175"
     CDS             complement(2496..2639)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_07175"
                     /product="hypothetical protein"
                     /protein_id="WP_193373691.1"
                     /transl_table=11
                     /translation="MGEKHHCSHPDVPPVDNVGFLDDVLAVEAERAGDEIRRLRLGERV
                     EL"
     gene            3748..4515
                     /locus_tag="CDO52_RS07195"
                     /old_locus_tag="CDO52_07180"
     CDS             3748..4515
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620017.1"
                     /locus_tag="CDO52_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07180"
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_017620017.1"
                     /transl_table=11
                     /translation="MNAEADHRTLHNRVLAELGPAISAGEYAPGHVFTLERLVQHYGVS
                     RTVAREAVRVLESMRLVVSRPRTGIRVRPPEEWSVYDPQLIRWRLAGPGRMAQLRSLTE
                     LRAAIEPPAAAAAARNASPAERTELVELNARMVETGEKGNLEEFLRLDIEFHRRILTLS
                     GNEMFAGLCGVVAEVLTGRTEYHLIPNPPRPEALRLHTHVASAVHGGLPDVAEAAMKAI
                     VSEIIAALEQVEDGAAWQGLAAGQNVVGDSYIT"
     gene            complement(4626..5228)
                     /locus_tag="CDO52_RS07200"
                     /old_locus_tag="CDO52_07185"
     CDS             complement(4626..5228)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620018.1"
                     /locus_tag="CDO52_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07185"
                     /product="HAD family phosphatase"
                     /protein_id="WP_017620018.1"
                     /sec_met_domain="HAD_2 (E-value: 2e-28, bitscore: 98.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPELVPHNADCLLFDWDGTLVDSQYTNYRAMSGALATEGVVLEQ
                     EWFDARTGLSSAEMIRTLVEERGLRLSRSVEQIVSERDELFLKEAHNVRPHAEVLKVVD
                     AMHRRLPMAVASGGARHIIEETLRHQPFHDHFDTLVTRDDVQRGKPAPDIFLRAAQDLG
                     AAPSRCTVYEDSDEGIAAAHAAGMAVIDVRPFTEARA"
     gene            complement(5278..6615)
                     /locus_tag="CDO52_RS07205"
                     /old_locus_tag="CDO52_07190"
     CDS             complement(5278..6615)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620019.1"
                     /locus_tag="CDO52_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07190"
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_152471743.1"
                     /transl_table=11
                     /translation="MRSPVVVRALTVFLASLGGLLFGYGTGVIAGVLPFITTAFELSSW
                     EQGAAVSAALLGATLTAPSSGWLADRFGRRPVILVAAAVYTVGTAASAAASGPLVLLSG
                     RFLVGLALGATSLAVPLYISEISPPARRGALVTLNQLMLTGGLLLSYVVAYLLEPTGAW
                     RWMLAVGIVPALVVLVGGFLVPESPDWLRSQGLGTRAKRAALRLGIDAGPEPSLTGPVR
                     GLELRKACAQAGPRWVALGLAIAVLVHLTGLNTAIYYAPTILVSSGLTSAGGIVGSILV
                     GVCNVLATVVTVLFLDRWGRRPLMIGGLLVMAAAAVAIAVAQFLGAVGAATALLLCVFI
                     TAGAVGPAAVFWVYIAEIYPSRTRGVLMSLATAAHWAADFLVATTFLPLVQGLSLAGAF
                     VVYAAITGAAALALGRWMPETRGRSLVSAREPASAIDQAPSTNPSS"
     gene            complement(6621..7661)
                     /locus_tag="CDO52_RS07210"
                     /old_locus_tag="CDO52_07195"
     CDS             complement(6621..7661)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620020.1"
                     /locus_tag="CDO52_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07195"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_017620020.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.1e-21, bitscore:
                     75.2, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 8.4e-24,
                     bitscore: 82.3, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRFAADSTTLRWGVLGATSYISTHVMPGIARTPGCELSAVASRP
                     ERAAAAAEVGRSFGATVHPDYGTLLADDALDAVYIPLPNSDHVDWTLRALAAGKHVLVE
                     KPMAMTENDCVRIEKAAEAASRTVMEAFMYRFHPQQRRTAELLASGEIGELRVVRASFA
                     FGIESGSGNIRLEPSLGGGATWDVGCYAVDVPLLFFGHVPQTVSARFSRRPGIDVETSA
                     VATMDFGQGRSAVVDYSIDYGPRSYYELQGTRGSITVRNAWAMEGEDGVITVLTHDGIR
                     EETIPSANHYQLQVAAFAEAVRDNVLAPMSLADSRNTARVGASLVASAAADGANIATTG
                     DATVVP"
     gene            complement(7658..9187)
                     /locus_tag="CDO52_RS07215"
                     /old_locus_tag="CDO52_07200"
     CDS             complement(7658..9187)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620021.1"
                     /locus_tag="CDO52_RS07215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07200"
                     /product="GMC family oxidoreductase"
                     /protein_id="WP_017620021.1"
                     /transl_table=11
                     /translation="MVSSETYDFVVVGAGAAGSALAARLSQNPDRKVLLLEAGPRDDDP
                     RIARPASWPLLLGSELDWGYRTVPQAALGGRELAWPRGRAVGGSGAINAMVHIRGAASD
                     FDAWERWGGDTWNARHMLPYLERLEGPADAEEYGRLPVAENTDPHPFATAFIEAAQKYG
                     LPGNPDFNAGQQEGVGLYRTTRTAASPDAPARRGNTARTYLRPALDRPNLTLWENTHVL
                     GILLADGRTTGVRVRRGTTVASVRCTGEVVVCAGTVASPQLLMLSGIGPADHLSALDIP
                     VAVDLPGVGGNLHDHVQVSLAYDTAHAHPVADSSNLGEAGGFLTLSRESPAPDVQLSFA
                     PMKDLNNAGRFGHGFTIGPGVTRPLSRGRLTLASADAGTHPLIDPAYLSDPADLDVLVE
                     GTRIARDIAATDPLADLASSAPLGEAPTRRELEEFVRANAQTQFHPAGTCRFGGDGDNE
                     AVVDPRLRVKGVRGLRVADASVIPNMITGNIHCAVVAIAERAAEFIQEENA"
     misc_feature    complement(9023..9025)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9225..10001)
                     /locus_tag="CDO52_RS07220"
                     /old_locus_tag="CDO52_07205"
     CDS             complement(9225..10001)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (14-128). E-value: 3.2e-14.
                     Score: 45.2. Matches aSDomain:
                     nrpspksdomains_CDO52_RS07220_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="CDO52_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07205"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_017620022.1"
                     /sec_met_domain="adh_short (E-value: 1.6e-34, bitscore:
                     117.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-29, bitscore:
                     102.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSREADAPHPHRGQVVVVTGGSAGIGRASAVAFSEAGMRVVIAAR
                     NEERGTEVVQEIRAQGGEALFAQCDVTSPHQVRELFTRSVDVFGRVDCAFNNAGIPGDG
                     RLAELEPEDFDHTFAVNTRGLWLCLREELRLMSAQGSGSVVNNTSVHGLRTVFPGIGAY
                     VASKHAAVALTRMAALEHAQEGIRVNAVAPGPIESDMLAASEAAVGGATTWRRLIPSGA
                     IGTPRQVADVALWLFSPSSSYVNGQVIGVDGGFLAT"
     aSDomain        complement(9618..9959)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CDO52_RS07220_PKS_KR.1"
                     /evalue="3.20E-14"
                     /label="CDO52_RS07220_PKS_KR.1"
                     /locus_tag="CDO52_RS07220"
                     /protein_end="128"
                     /protein_start="14"
                     /score="45.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVVVTGGSAGIGRASAVAFSEAGMRVVIAARNEERGTEVVQEIRA
                     QGGEALFAQCDVTSPHQVRELFTRSVDVFGRVDCAFNNAGIPGDGRLAELEPEDFDHTF
                     AVNTRGLWLC"
     CDS_motif       complement(9876..9956)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CDO52_RS07220_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="CDO52_RS07220"
                     /protein_end="42"
                     /protein_start="15"
                     /score="11.7"
                     /tool="antismash"
                     /translation="VVVTGGSAGIGRASAVAFSEAGMRVVI"
     gene            complement(10001..11206)
                     /locus_tag="CDO52_RS07225"
                     /old_locus_tag="CDO52_07210"
     CDS             complement(10001..11206)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620023.1"
                     /locus_tag="CDO52_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07210"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_033301016.1"
                     /sec_met_domain="salQ (E-value: 1.4e-147, bitscore: 489.7,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 5.6e-62, bitscore:
                     207.6, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYPSPRTQGWRVKAQLDVEYEVIETPGLLDPDNPELLAVPGGGST
                     TDTRLIILDHAVDELYGTRIRSYFAENSATVEYLTLPGSEEYKSIDRALEVVNKLNEVG
                     TNRLSNPPIVIGGGVVADVVGVAASLYRRGIPFIRVPTTLLSQVDVSVAAKSGVNYGGY
                     RNRLGSYTPPPRTLIDREFLATVPDRQLRNGMGEIFKMALIKDQRLFELLEEHGAELIQ
                     HRFQDPTPGYDGLTGTIADEVIGRSIAGMAEELEPNLWEKNLQRSVDYGHSFSPLVEMR
                     ASPELLHGEAVAMDCVFSAIIAAHRGLISGADLDRIIAVARRLGLEPSHPLFSDVALVS
                     EALADTIRHRNGQQNLPILTGIGAVCFLNDVTEGEIAQACDGMGRLLASHADDHAQSVG
                     AS"
     misc_feature    11206..11219
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(11540..11558)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.31"
                     /tool="antismash"
     misc_feature    11554..11563
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.75"
                     /tool="antismash"
     misc_feature    11744..11759
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            12148..13056
                     /locus_tag="CDO52_RS07230"
                     /old_locus_tag="CDO52_07215"
     CDS             12148..13056
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890871.1"
                     /locus_tag="CDO52_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07215"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_094932276.1"
                     /sec_met_domain="APH (E-value: 2.2e-36, bitscore: 124.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSTPVDGRAGIDVALVRRLIAAQFPRWKNLPVRPVEVDGLDNRT
                     YRLGDDMTVRLPTAAGYAPAVDKEHDWLPRLAPALPVAVPPILAKGEPGEGYPFPWSVR
                     GWLHGETADRGRIDDMPRFAVAVAEFIHALQRCDATGGPLAGEHSWYRGASPAHYDEGT
                     RRYLAVLDGRVDTDRAAAVWETALAAMWSGEPVWFHGDMAPGNLLVADGKLTAVIDFGT
                     SGVGDPACDLVIAWTMFSGDSRHAFREAVGHDEGTWARARGWALWKALLLLAGTIDTDQ
                     DEADINRRVVDEVLADHDRFG"
     gene            13267..13557
                     /locus_tag="CDO52_RS28080"
     CDS             13267..13557
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS28080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_017620025.1"
                     /transl_table=11
                     /translation="MERGINRLKRHRAAATRIDKLAVRYQATIHIAAINEWLSPALKHD
                     LADTPWDADIAAPGDDPTLRETTFGGGRGLLSFRGDDDAEMVHVFAIAWIG"
     gene            complement(13639..14016)
                     /locus_tag="CDO52_RS07240"
                     /old_locus_tag="CDO52_07225"
     CDS             complement(13639..14016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574976.1"
                     /locus_tag="CDO52_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07225"
                     /product="VOC family protein"
                     /protein_id="WP_017620026.1"
                     /transl_table=11
                     /translation="MACRISELVLDCHDPEVLARFWCEVLDFMVLDRDEGDIEIGPREG
                     FGGPQPTIILSRDDEPKNGKLRLHIDVNATDRDQDAELERLLAAGAELVDIGQTGEEPW
                     HVLADPEGNEFCLLKARLDPL"
     gene            14381..14743
                     /locus_tag="CDO52_RS07245"
                     /old_locus_tag="CDO52_07230"
     CDS             14381..14743
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620027.1"
                     /locus_tag="CDO52_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07230"
                     /product="hypothetical protein"
                     /protein_id="WP_198345834.1"
                     /transl_table=11
                     /translation="MSLRVRMREALPEAMRARDRVAVRVLRATLAALDNAEAVPADEAE
                     LRGSAIEQSPVGVGVSEAARRELSERTVADIVQAEAAERLEAAMQLTAPMHADRAAQLR
                     AEAAVLLRFLDGAGGV"
     gene            complement(14961..15458)
                     /locus_tag="CDO52_RS07250"
                     /old_locus_tag="CDO52_07235"
     CDS             complement(14961..15458)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_07235"
                     /product="hypothetical protein"
                     /protein_id="WP_017620028.1"
                     /transl_table=11
                     /translation="MPEDSPELDKSGLPPEPTKDAPVSERVEWSLIETTSVYARWYGDG
                     VEADCPEVSGSGGFGSSEDITCTVTVDGISAKWDVSIGSIMSEMEPVDGRHVVRSAVED
                     VARYKTKSEHVRCEMDEVQLVSPDDEPITCVWANEDDHGRLVMRLDNMQFSDKSFWLTS
                     AD"
     misc_feature    complement(15571..15585)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.54"
                     /tool="antismash"
     gene            15802..16566
                     /locus_tag="CDO52_RS07255"
                     /old_locus_tag="CDO52_07240"
     CDS             15802..16566
                     /NRPS_PKS="Domain: PKS_KR (4-169). E-value: 3.2e-11. Score:
                     35.4. Matches aSDomain:
                     nrpspksdomains_CDO52_RS07255_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620029.1"
                     /locus_tag="CDO52_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07240"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_026126049.1"
                     /sec_met_domain="adh_short (E-value: 3.4e-38, bitscore:
                     129.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.5e-05,
                     bitscore: 21.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRTIFITGASAGFGAAIARRFAAEGARIVATARRAERLDDLRK
                     ELGDDVVLPVALDVRDRAAIERVVTDLPPDFADVDVLVNNAGLALGLEPAHEADPNDWQ
                     RMLDTNCAGLMHCTRALLPGMVERGRGHVVNMGSIAGSYPYPGGNVYGATKAFVQQFSR
                     NLRADLLGTGVRVTCVEPGLVGGTEFSSVRFGGDSERAAAPYTNTEPLTPEDIAETVHW
                     VVSQPPHVNVNAVELMPVSQAFGPMRIHRTES"
     aSDomain        15814..16308
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CDO52_RS07255_PKS_KR.1"
                     /evalue="3.20E-11"
                     /label="CDO52_RS07255_PKS_KR.1"
                     /locus_tag="CDO52_RS07255"
                     /protein_end="169"
                     /protein_start="4"
                     /score="35.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TIFITGASAGFGAAIARRFAAEGARIVATARRAERLDDLRKELGD
                     DVVLPVALDVRDRAAIERVVTDLPPDFADVDVLVNNAGLALGLEPAHEADPNDWQRMLD
                     TNCAGLMHCTRALLPGMVERGRGHVVNMGSIAGSYPYPGGNVYGATKAFVQQFSRNLRA
                     DL"
     CDS_motif       15817..15909
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CDO52_RS07255_0001"
                     /evalue="2.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="CDO52_RS07255"
                     /protein_end="36"
                     /protein_start="5"
                     /score="16.8"
                     /tool="antismash"
                     /translation="IFITGASAGFGAAIARRFAAEGARIVATARR"
     gene            complement(16613..17590)
                     /locus_tag="CDO52_RS07260"
                     /old_locus_tag="CDO52_07245"
     CDS             complement(16613..17590)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013224.5"
                     /locus_tag="CDO52_RS07260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07245"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_094932809.1"
                     /transl_table=11
                     /translation="MRHRLDDTDRRIVAALLASPRASWRTVSDTIGVSERTVVRRAGPL
                     LQDGTVRVTAVRNPGCFPELIPMALRIRCRPRRIRAVAAVLAERPDTVWVDVLSGGDEI
                     STVVFLDGPEARNRLLLRDLPATEAVDSWTSHTLLRVFPAAFDWTGGLLSPAEAEVLRR
                     EVASPPGGLALDDTDHALIRGLADNGRATYTELARRARTAALTARRRTDLLADRVVRLA
                     TEVDLALLGIHAEALLWMTVAPGGLDATAHALSRHPQIHFTAATTGPANLMAAAAAADL
                     DALYSLLTDTIGGLRHVTGIETTPILATFKRAGLPRPNADRAAH"
     gene            17770..19407
                     /locus_tag="CDO52_RS07265"
                     /old_locus_tag="CDO52_07250"
     CDS             17770..19407
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620032.1"
                     /locus_tag="CDO52_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07250"
                     /product="amidohydrolase"
                     /protein_id="WP_017620032.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.6e-07, bitscore:
                     28.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNREATADLVVRAGTVHTMAAAERPVTALAVRRGEIVAVAAPENA
                     QDLLETWSGPGTTVLDDPGLVVLPAIVDTHNHLMLAARNSLGAPVSLAQDIPRFLELIR
                     ERAAHTPSGQWIITGADWHELHLAERRMPTAEELDRATTDHPVLVLRGGHNGVLNSAGL
                     RLAGIGPDTPDVQGGYIARDAAGRPTGRVQDAALELAQKALPALPAGALATGLAHASTE
                     YAAHGIGSVRDPAVTPQEWHTYVRAQADGRLSVRSHAMILSTPASIFAAGSMGAYLDAL
                     EAQGITPDAGQGRLRLWGLKFILDGGVEAAALERPYADRPGYHGDLMWDRDDLAQCLAV
                     CVRRGWPVGTHAFGDRAVAVLLDAIRDVVGQHGPIPPGALVIEHGGLIGGDQIADAVDL
                     GVHITVQHALSDGLGPALLASFGPDRTAALWPLRELVDSGAWISAGTDHPIGPLDPLRC
                     VHGMTTRHTPTGVRGPEHAIDRAEALRLYTSSGARLLGHAATGTLVPGAPADMVAYRAD
                     PFTCPADDLLRLAPEITAVGGEVVYRRA"
     misc_feature    19527..19545
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.54"
                     /tool="antismash"
     misc_feature    complement(19528..19546)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.68"
                     /tool="antismash"
     misc_feature    complement(19714..19732)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 22.34"
                     /tool="antismash"
     misc_feature    complement(19873..19883)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            19878..20312
                     /locus_tag="CDO52_RS07270"
                     /old_locus_tag="CDO52_07255"
     CDS             19878..20312
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620033.1"
                     /locus_tag="CDO52_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07255"
                     /product="VOC family protein"
                     /protein_id="WP_051060846.1"
                     /transl_table=11
                     /translation="MASTTDRTDTQAVSAKAPVARVASYAFGGHDGRALAEFYAAALGW
                     EVTQEFPDENGVPVAFIVTDGTTIYTFYTARDFRAPNWPEDELPFHLDLMFDDVAAGEK
                     RLLDLGATRPDHQPGGEHWTVLLDPSGQPFCISPATNWQW"
     misc_feature    complement(20429..20443)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            20727..21110
                     /locus_tag="CDO52_RS07275"
                     /old_locus_tag="CDO52_07260"
     CDS             20727..21110
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620034.1"
                     /locus_tag="CDO52_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_07260"
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_017620034.1"
                     /transl_table=11
                     /translation="MSRRRDERARPRSGRNADAFRCLHCRLDVPMSAPGTRHRNHCPNC
                     LYSRHVDRDIPGDRAAECGARMEPIAISVRGDGEWVIIHRCTACDELGANRTAGDDNPL
                     MLVRMATRPLAAPPFPLERLAAL"
ORIGIN
        1 ggtcggcgac cacggtgacg gtgtggccgt gcaggcgaag gtcgtgggcg atgctcaacc
       61 ccatgacacc cgctccgatg acggcgatcc gccggtgccc aggcgcgttc tcgcggtcgt
      121 cgtggcgggc cggagagtgg atggccatgg tgcctcatca tggttcaccg ccatccgacg
      181 gcacaacacc ggtgcggtct cgcctggtca tcagggcttg ccccggagtc ctgggcacgt
      241 cgtgccatac ggccgtgacc agcgtcagcc atcgccggag caccgccagc cgggcgtcac
      301 atacccgcgg gccagcggtt gttgtccaga cgcaggggac ctcctcccat cagcggacac
      361 cgtcttccct ggcgcaggac tggacacaca gcaaatcgcg aaccatacgg gcgtgaagca
      421 cgaccgctac caggcggagc tcaacggttg gagaggaccc gccgcgctcc tcatcagtcc
      481 cgatggagga actcgcggag gcgagcggcg aacgtgtcgg gctgctcggt gaaacccacg
      541 tgaccaccgg gaaagaagac gggtgccgag ccgagcgctg ccgcgagtgc ccgggaggtg
      601 cggtcacaca gctgaccggt tgagtcctca ccgatgccga cgacgatgcg ggtcgcggcg
      661 tcacgcaaaa ggtcgaggtc ggggttggcg catcgtgtgc aggaagaacc gccggtcctc
      721 ggcggcctcc ttctcggtgc gctgcccgaa catctgttgg aagacctcct ctggcatagg
      781 gaggccggcg atgtccatga acgtgcgcca cgcccccaac gcatcgccgg agacataggt
      841 gtcgatcatg tcctcggatg ccgcgatgag ctcgtcgtgg tcgtcgagca tgttgtagag
      901 cgggggctcg tgggcgatca cggtgtgcgc ctggtcggga tgggtttggg cgagtgcgag
      961 cgttccttcc cgtagaggat ggggaggcgc ttccccttca aactccatac ctggagaacg
     1021 ccgaccggcg cagcatgatt cggtcaaagc gccacgggca ttgagatccg accaacctgg
     1081 ctctgggtgg ttaccgggca aggatgccgc tttggtgtgg ctccaccctc tcgtcggcac
     1141 ctgttgtgtc cggatcgcca tgcccaggat cagccacgag ggcgacgtga tcggatgcgg
     1201 ggtcacctcg gcatcctgcc aaaaccgtat tggcgcgagg cgtcggctgc gcggaaaaac
     1261 ctccacgccc agtaccgggt gtccacgcgt tcggccgggg tgagttccgc gaggaacagc
     1321 gggccaccgg caagccgccg gacatgggga aggcgtggga ccggacgggg gtaccgccgc
     1381 gcgggtgcgg taattctgtg aatgaccgct acgccccgtg cgtccctcgg tagcgttccg
     1441 aatatgccta cccctgaccc ccaagacatg tctgcggtca ccggcgaggg ggaagacgag
     1501 ctcctttccc gtgtcatgcg cctttcgctt ggtcgcggcg tcgagtacgt cctccggaat
     1561 taccccgacg acacggtcga gttccttctg gagaccgcga gagacctgat cagcaagggc
     1621 cagtgcgaac gggcgatggc cgtgtacgag gcggtcatcg cggcgccgcc gtcggaagcg
     1681 gacgcccagg acgccatggt cgagagaatc gacctgctcc ttgagcaggg cgacaccgct
     1741 gcggcggacg aggctatcgg cgagctgtcg aaacgcgggc cgatggagat gcccgccgtc
     1801 ctcctcgccg agagccttga ggcgcgggag cgactggaag atgctctcac ctggttcaac
     1861 agtgcctgcc gtcgtggtct caggcaggtt cccgaggatg cggtgcggaa tctcctcgat
     1921 ctgggggccc tgcgggggcg cgcccgggtg cgatcagcgc tcggcttggc agaggacgag
     1981 ttcgatgtgg cggtgtggac acaatacggc gagagtcgaa tgggtggacg ggagcgtctc
     2041 gtcgagtcgg ccgctgggca ggaagcgttg ccccagggca cgatcagcgc gtgcttcacc
     2101 cggtcctcgt tcgaccgtgc tcggcgggag ggcctgctgt acggggagga agcggagcgg
     2161 gctggtgatg accctgacgc ctactacctg gcggccgagc gggcggttcg gcggttggcg
     2221 gaggagcacc cggacgtcaa ggtgtacttc gccgtgcaca gcgtcgagga ccttgtcgcc
     2281 tacgcggcgg agaacgggcg tgaccacgcc gctccggaga cgcggaacgc gttcgtcgaa
     2341 acgctacgtg aggacgatcc gcgcatcatc gcttggcccc cgaggcgcaa tgaggcgtgc
     2401 tggtgcgggg ccggccgaaa gtacaagaag tgctgtggtt ccccgtcgaa gcgctgagcg
     2461 acgtcggccc gacctcgcat aggctgccgc cccgcctaca actcgacgcg ttcgccgagg
     2521 cggagccgcc ggatctcgtc cccagcccgc tcggcttcca cggccaggac gtcgtccagg
     2581 aacccgacgt tgtcgaccgg aggcacatcc ggatggctgc agtggtgctt ctcgcccacc
     2641 acggacacct cgaagcttcg tgattcccat ggtcgccagc ctgccaatcg gccagggaag
     2701 cgacatcaac gttcgcgacg ggccgaagcc gacgaaacgg gaaggttcgt gatctccggc
     2761 tggagtgccg caccacacgc gtagatcgtg atctggtcag ctgggtctgg gcgtaaccga
     2821 ccgagtcggc ggtcggatcc gcgttctcct ggtcgaggca ggcattgaac tcggcgagcg
     2881 gggcacccat gaccgccgcg aacccgtgga ggggctcgtc tagcgacatc gacgcggctg
     2941 catcccggtc gaccttcgcc cgttcccggc gcagcctata acggcgttcg acggcgccgt
     3001 gcacccgctg cggcgatgag gccgcaccgc gtcagtaccc cctcctactg gaagaggcga
     3061 gtagcgccgc tcgtacgagt cgtggctcgc gacggcaggt tctccacgct ccacgcccga
     3121 gcgcagcccg gccgaggtaa gtgggatgga acccccgacg gcagccgaag cggtcccagc
     3181 tctcgctcgt ggtgactctg tcggttctcg tcgcgtactt gcgcacaggc aggtgcgcgg
     3241 atgccgacca tgaaatcggt gacccccagg tccacctcag cgacatcctg cactgtcggc
     3301 gccgatgcct ttcccatccc ttcgtcgaat gcctgcagtc gccggacagc aggccctcgg
     3361 ccgacatccg gcccaggccg gtagcgtgaa cggtctcggt gtgtagggct ctgcggcccg
     3421 ggggtgattc cggtggcatc ggcggtcagc cgcgatccgg gggagggctg ggcggtcttc
     3481 atatgagagg tgcttttgat tcacgcggaa actactacct caatgacctc agcgaacatc
     3541 atcgccccaa tacaaggagc ggtttgggta tgtcgggggg cgttagcggc cacgctctct
     3601 gtgtgaggcc gaggtgagtg acgcggcacc gtccacgaag cctcactcgt tcggtcaggc
     3661 cagtgcctca gccattcccg gcgcccctgt taccgctcgc cccgcagacg gtcgaaaacc
     3721 gagcccagag aggatgggga aggacctgtg aacgcagaag ccgaccaccg caccctgcac
     3781 aaccgcgtgc tcgcggagct ggggccggcg atctcggccg gtgagtacgc tcccggccac
     3841 gtgttcacgc tcgagcgcct tgtgcagcac tacggcgtct cccgaaccgt ggcccgggag
     3901 gccgtgcggg tactggagtc gatgcggctg gtggtgagtc ggccgcgcac cggcatccgg
     3961 gtgcgtccgc ctgaggagtg gagtgtctac gaccctcagc tcatccgctg gcgcctggcg
     4021 ggccccggac ggatggccca actgcgttcg ctgaccgagc tgcgcgcggc gatcgaacct
     4081 ccggccgctg ctgctgccgc ccggaacgcc tcgcccgcgg aacgcacgga gctggtcgag
     4141 ctgaacgccc gcatggtcga gaccggagag aaggggaacc tggaggagtt ccttcggctc
     4201 gacatcgagt tccaccgccg catcctcacg ctgtcgggca acgagatgtt cgcggggctg
     4261 tgcggagtcg tcgccgaggt gctcaccggt cgcaccgagt accacctgat tccgaaccct
     4321 ccccggcccg aggcgctccg cctccacacg cacgtcgcct ccgcggtcca cggcggtctc
     4381 cccgacgttg cggaggccgc catgaaagcg atcgtcagcg agatcatcgc ggcactggag
     4441 caggtcgagg acggtgcggc ctggcagggc ctggcagcag gccagaacgt ggtcggggat
     4501 tcctacatca catgaggaac gctcgaccac ggaaggtagg gaccccgtgt attccgggcg
     4561 tatgtcggta gggccggacg agcgtggccg cgattcggcc tgcgcctctg atcggccggc
     4621 tgccgtcagg ctcgggcctc ggtgaagggg cggacgtcga tgacggccat gcccgcggcg
     4681 tgggccgcgg cgataccttc gtcgctgtcc tcgtagaccg tgcagcgtga gggcgcggct
     4741 cccaggtcct gggccgcgcg aaggaagatg tccggggcgg gcttgcctcg ctgcacatca
     4801 tcacgggtca ccagggtgtc gaagtggtcg tggaacggtt ggtgccgcag cgtctcttcg
     4861 atgatgtgac gggccccgcc cgacgccacc gccatcggca gtcgacggtg catcgcatcg
     4921 acgaccttga ggacctccgc gtgcggtcgc acgttgtggg cctccttgag gaacagttcg
     4981 tcgcgctccg agacgatctg ctccacagag cgggacaacc gcaggccgcg ctcttcgacc
     5041 agggtgcgga tcatctccgc ggaggagagc ccggtgcggg catcgaacca ctcctgctct
     5101 aggaccacgc cctcggtggc caaggcgccg gacatggcgc ggtagttggt gtactggctg
     5161 tcgaccaggg tgccgtccca gtcgaagagc aggcagtccg cgttgtgagg tacgagttcg
     5221 gggtgcatgc gagagtacgc tttcctgttt cgtcggaggc cgggacggtc tcgggggtca
     5281 gctggacggg ttggtggagg gcgcctggtc gatggcggag gcgggctccc gtgcggagac
     5341 gagcgagcgt cctcgtgtct ctggcatcca tcggcccaat gccagggccg cggctccggt
     5401 gatcgccgcg tagacgacga acgctccggc gagcgacaag ccctggacga ggggcaggaa
     5461 cgtcgtcgcc accaggaagt ccgctgccca gtgtgcagct gtggccagac tcatcaggac
     5521 accgcgtgtc cgcgaggggt agatctcggc gatgtagacc cagaacaccg cggctggccc
     5581 gacagccccg gccgtgatga acacgcacag cagcagcgcg gtcgctgccc ccaccgcccc
     5641 gaggaactgg gcgacggcga tcgccacggc agcggccgcc atgaccagca gtccgccgat
     5701 catgagtggg cgccgccccc accggtcaag gaacagcacg gtcaccaccg tggccaggac
     5761 gttgcacacc cccaccagga tcgatccgac gatgcctccg gcggaggtga gtccactgga
     5821 cacgaggatc gtgggcgcgt agtagatcgc cgtgttcagg cccgtcaggt ggacgagtac
     5881 cgcgatggcg aggcccaggg ccacccatcg ggggcccgcc tgggcgcagg ccttgcgcag
     5941 ttcgagcccg cgcaccgggc ccgtcaggct gggctcgggt cccgcatcga taccgagccg
     6001 gagcgccgcc cgcttcgccc gggtgccgag cccctggctg cgcagccagt ccggcgactc
     6061 cgggaccaga aagcccccga ccagtaccac cagggccggg acaatgccga cggcgagcat
     6121 ccagcgccag gcaccggtgg gctccagaag gtaggccacc acataggaca gcagcaaccc
     6181 gccggtgagc atgagctggt tgagggtcac cagtgcgccg cggcgggcgg gcggcgagat
     6241 ctccgagatg tacaacggca cggcgagcga cgtggccccc aaagcaaggc cgaccaggaa
     6301 gcgtccgctc aggagcacca gcgggccgga agcggcggcg gaggcggcgg tgcccaccgt
     6361 gtacaccgcc gccgcgacga ggatcaccgg gcggcggccg aaccggtcgg ccagccaccc
     6421 gctgctggga gcggtcagtg tcgcccccag cagggcggcc gacaccgccg ctccctgttc
     6481 ccaggacgac agttcgaacg ccgtggtgat gaagggcagc accccagcga tcacgcccgt
     6541 tccgtagccg aacagcaggc cacccaggga cgcgaggaac accgtcagag cgcgcaccac
     6601 caccggtgac cgcatcgcgg tcacggaacc accgtcgcgt cacccgtggt ggcgatattg
     6661 gccccatcgg cggccgcgga ggccacgaga gacgcgccca cgcgggcggt gttccgggag
     6721 tcggcgagcg acatgggggc gaggacgttg tcgcgtacgg cctcggcgaa ggcggcgacc
     6781 tggagctggt agtggttcgc tgagggaatg gtctcctcgc ggatcccgtc atgggtgagc
     6841 acggtgatca caccgtcctc gccctccatg gcccaggcgt tgcgcacggt gatgctgccg
     6901 cgagttccct ggagctcgta gtaggaacgg ggcccgtagt cgatgctgta gtcgaccacc
     6961 gcactgcgcc cctggccgaa gtccatcgtg gcgaccgcgc tggtctccac gtcgatcccc
     7021 gggcggcggc tgaatcgggc actgacggtc tggggcacgt gcccgaagaa cagaagcggg
     7081 acgtccaccg cgtaacagcc cacgtcccag gtggcgcccc cgcccagcga cggttccaac
     7141 cggatgttgc cgcttcccga ctcgatgccg aacgcgaacg aagccctgac gacccgtagc
     7201 tcaccgatct caccggatgc gaggagctcg gcggtgcgcc gctgctgcgg gtggaaccgg
     7261 tacatgaagg cttccatgac agtgcgcgag gccgcctcgg ccgccttctc gatgcgtaca
     7321 cagtcgtttt cggtcatcgc catgggcttt tcgaccagga cgtgtttgcc ggcagccagt
     7381 gcccgcaggg tccagtcgac gtggtcggag ttggggagtg ggatgtagac ggcgtcgagc
     7441 gcgtcatccg cgaggagcgt cccgtagtcg gggtgcacgg tggcgccgaa ggaccggccg
     7501 acctccgctg cggcggccgc ccgctcgggg cggctcgcta cggcggaaag ctcgcagccg
     7561 ggggtgcggg cgatgccggg catcacgtgc gtgctgatgt aggaggtggc gcccagtacg
     7621 ccccagcgca gggtcgtgct gtccgctgcg aatctcgtca tgcgttctcc tcctggatga
     7681 actccgctgc gcgctcggcg atcgcgacca cagcacaatg gatgtttccg gtgatcatgt
     7741 tcggaatgac ggatgcgtcg gccacccgca gaccacgcac gcccttcacc cggagcctgg
     7801 gatccacgac ggcttcgttg tccccgtcgc cgccgaaccg acaggtaccg gccgggtgga
     7861 actgggtttg cgcgttggcc cggacgaact cctcgagttc ccggcgcgtg ggtgcctcgc
     7921 ccaggggagc gctgctggcc aggtccgcga gggggtcggt ggcggcgatg tcgcgggcga
     7981 tccgcgtccc ttccaccagt acgtcgagat ccgcggggtc ggacaggtag gcggggtcga
     8041 tcaacgggtg cgtgcccgca tcggcggagg cgagggtgag cctgcctcgg ctgagcggac
     8101 gggtgacgcc cggcccgatg gtgaagccat ggccgaacct gcccgcgttg ttgaggtcct
     8161 tcatcggagc gaaggacaat tgcacgtccg gcgctggtga ttcgcggctg agagtgagga
     8221 atccgcccgc ctcgccaagg ttggacgagt cggcgacggg gtgcgcatgg gcggtgtcgt
     8281 aggccagcga cacttgcacg tggtcgtgca ggttgccgcc gaccccgggc aggtccaccg
     8341 cgaccggaat gtccagcgcg gagaggtggt cagcgggtcc gatgccactg agcatgagca
     8401 gttgcgggct cgccaccgta cccgcgcaca cgacgacctc gccggtgcag cgcacggatg
     8461 ccaccgtcgt gccgcgccgt acccggaccc ccgtggtgcg cccgtcggcc aggaggatgc
     8521 cgaggacgtg cgtgttctcc cacagggtga ggttcggacg gtcgagggcc gggcgcaggt
     8581 aggtgcgggc ggtgttgccc cggcgggcgg gagcgtcggg ggaggcggcg gtgcgtgtgg
     8641 tgcggtagag gccgacgccc tcctgctggc cggcgttgaa gtccggatta cccggcaggc
     8701 cgtatttctg cgcggcctcg atgaatgctg tcgcgaaggg gtgcgggtcg gtgttctcgg
     8761 ccacggggag gcgaccgtac tcttccgcgt cggcggggcc ctccaaccgc tccaggtacg
     8821 gaagcatgtg ccgtgcgttc caggtgtcgc cgccccaccg ctcccacgcg tcgaagtccg
     8881 atgccgcgcc gcggatatgc accatggcgt tgatggcccc agacccgccc acagcacggc
     8941 cgcgaggcca ggcgagctcc ctgccgccga gcgcggcctg cggcaccgtc cggtaccccc
     9001 agtccagctc gctgccgagg agtaacggcc aggaggccgg gcgggcgatc cgcggatcgt
     9061 catcacgcgg tccggcttcc agcagcagga ccttgcgatc ggggttctga ctcaaccgtg
     9121 cggcgagagc gcttccggcg gcacccgcgc cgaccacgac aaagtcatac gtttcagagc
     9181 tgaccatggg gaattccttc gttccacgga gctggcgatg ggcgtcaggt ggcgaggaac
     9241 ccgccgtcga ctccgatgac ttgcccgttg acgtacgacg aggacgggga gaacagccac
     9301 agagccacgt cggcgacctg acggggagta ccgatcgcac cggaggggat cagccgccgc
     9361 cacgtggtcg ccccgcccac cgccgcttcc gaggcggcca gcatgtcgga ctcgatcgga
     9421 cccggggcca ccgcgttgac gcgtatccct tcctgggcgt gctccagggc cgccatgcgg
     9481 gtcagggcga ccgccgcgtg tttggaggcc acgtaggcgc cgattccggg gaagaccgtg
     9541 cgtagcccgt gcaccgaggt gttgttgacg acgctgccgc tcccttgggc tgacatcagt
     9601 cgcagttctt ctctcagaca gagccacagt ccccgcgtgt tgaccgcgaa ggtatggtcg
     9661 aagtcctccg gttccagttc ggcgagccgc ccgtctcccg ggattcctgc gttgttgaag
     9721 gcgcagtcca cgcgaccgaa cacgtcgacg gaacgggtga acagctcgcg tacctggtgg
     9781 ggactggtga cgtcgcactg cgcgaatagc gcttcgcctc cctgagcgcg gatctcctgc
     9841 acgacctcgg ttccgcgttc ctcattccgc gccgcgatga cgacgcgcat tcccgcttcg
     9901 gagaacgcga cggcggacgc gcggccgatg cccgcgctgc cgccggtgac gaccacgacc
     9961 tgcccccggt gggggtgtgg ggcatcggct tcgcggctca tcagctggcc ccgacagact
    10021 gcgcgtggtc gtcggcgtgc gatgccagca ggcgtcccat cccgtcgcac gcctgggcga
    10081 tctcgccctc ggtgacatcg ttgaggaagc acaccgcacc gatcccggtg aggatcggca
    10141 ggttctgctg accgttccgg tgacggatcg tgtccgccaa ggcttcggat acgagcgcca
    10201 catcactgaa gagcggatgc gaaggctcca gcccgagccg ccgcgccacg gcgatgatgc
    10261 ggtcgaggtc agcgccactg atcaagccgc ggtgagcggc aatgatggcg gagaacacac
    10321 agtccatggc caccgcttcg ccgtgcagga gttccgggga cgcccgcatt tccacaagcg
    10381 gtgagaacga atgcccgtag tcaacggagc gctggaggtt cttctcccac aggttcggtt
    10441 cgagttcctc ggccattcct gcgatggacc ggccgatcac ctcgtcggcg atcgttcccg
    10501 tcaacccgtc gtatccgggc gttggatcct ggaagcggtg ctgaatgagt tccgcgccgt
    10561 gctcctccag cagctcgaac agacgctgat ccttgatcag cgccatcttg aagatctcgc
    10621 ccattccatt gcggagctgc cggtcgggaa cggtagcgag aaattcacgg tcgatcaggg
    10681 tgcgtggagg tggagtgtag gagccgaggc ggttgcggta gccgccataa ttgacgccgg
    10741 acttggccgc cacactgacg tccacttggg agagcagggt tgtcggtacg cgtatgaacg
    10801 gaatcccgcg ccggtagaga ctcgcggcga cccccacgac atcggccacg actccgccgc
    10861 cgataacgat gggcggattg ctcagacggt tcgtgccgac ttcgttgagc ttgttgacca
    10921 cttcaagggc gcgatcaatg gacttgtact cctcggatcc gggaagcgtc aggtactcga
    10981 ccgtcgcgga gttctcggcg aagtacgaac ggatcctggt cccgtatagt tcgtcgacgg
    11041 cgtgatcgag gatgatgagc cgtgtatccg tggtgctccc gccgcccggg acggcgagga
    11101 gctcagggtt atcgggatcg agcaaccctg gagtttcaat gacctcgtat tcgacgtcga
    11161 gttgagcttt gactcgccat ccctgggtac ggggagaagg gtacacaaac tctcctttgt
    11221 gaagaatgtg acgcatggca acacggcgct cgacgctgcc ctgggcattg cgtggtcact
    11281 tcgcgcagga ccatatacct gatcaggact tcgaatcgcc ggcgcaaagc cgaaaggtga
    11341 attgaccccg gatcaccgcg gagatcgtat gagtgtggcc tggtttatct tccgcgaggc
    11401 ggggttttca gggcgttggc gaggcggtag ccaaccgcac tgatgtaggt gaagcggccg
    11461 ctttggttgc acacttaaac aagtatggac ctcccccgag gaaacgctct ccacgtcgcg
    11521 gacatcgctg tccgcggaaa ctgagatgcg ttctgatttt tgacatgttt gtccgcctct
    11581 gggtagtgac ggtactcatt tcatccgcta accgtcaatg atgatcaggt ggggcatttg
    11641 accgttttgc ccgtattgga aatatccaat ttacatctgg actgcggatc atcggttgtt
    11701 actccaggtc actgcatggc tgtttgcgat tcatcgaatt tctggtgatt tgcgtcacat
    11761 cgtcgttcac ctggatcttg cacaagcttc acctgacgcg ctgctggagc ctgtgctcgc
    11821 ggggagagtt ggacgtcatc gagaccatcc gaaggggcct cggtccgaaa ggagcttttc
    11881 ggggcatgca gcaccgcgga agggagtcat tttgttcggc cagtggcccg acgccgagtg
    11941 atgggcgcct gttctgtgcg acctcgggag ctctagtgcg gcagggcctg cccggggtcc
    12001 tacggcagct ccgaccgctg gtcgaggagg accggttgag cagccggaac gttggcgctg
    12061 ccctgggctt gagggctggg cggaccgtca tcggtgcctg ccgataattc gttgggcgga
    12121 acgccccctg gaggcgataa tcccggcatg gtttcgacgc ccgtggacgg ccgtgccgga
    12181 atcgacgtcg ctctggtgag gcgtctgatc gccgcgcagt tcccgcgatg gaagaaccta
    12241 ccggtgcggc cggtggaggt cgacggtttg gacaatcgga cctaccgcct gggtgacgac
    12301 atgacggtgc gcctgcccac ggccgcaggc tatgcccctg ccgtggacaa ggagcatgac
    12361 tggctgccgc ggctcgcccc ggcgctgccg gtcgctgtgc cgccgattct cgccaagggc
    12421 gagccaggag agggataccc cttcccctgg tccgtgcgcg gctggctgca cggcgagacg
    12481 gctgatcggg gacgcatcga cgacatgccg cggttcgcgg tggcggtggc cgagttcatc
    12541 catgccctgc agcggtgtga cgccaccggt gggccactcg ccggtgagca cagttggtac
    12601 cgcggggctt cgccagccca ctacgacgag gggacgcgcc gctacctggc cgtgctggac
    12661 gggcgtgtcg acacggatcg ggccgccgcc gtctgggaga ccgccctggc cgccatgtgg
    12721 tccggtgagc ccgtgtggtt tcacggcgac atggccccgg ggaatctgtt ggtcgcggac
    12781 gggaaactga cggccgtcat cgatttcggc acctcaggcg tcggcgaccc ggcctgcgat
    12841 ctggtgatcg cgtggacgat gttctccggc gacagccgtc acgcgttccg cgaggcggtg
    12901 ggccacgacg agggcacctg ggcgcgtgcc cgaggctggg cgctgtggaa ggcgcttctg
    12961 cttctggccg gaaccatcga caccgaccag gatgaggccg acatcaaccg gcgggtcgtc
    13021 gacgaggttc tcgccgacca tgaccgcttc ggctagcgcg tgcccggatc tctctacggg
    13081 cttggccggt ccctccgccc gcccaccggc atgcctcccc tcgctgggtc tgcggatgat
    13141 gatgcgcccc gacggctggg ttgaccctcg aaggggacca agcggcagct gatcgatggc
    13201 atccggtggc cgtagcgggc gtccgcccgc tttcgcgacc ctggtgacga ccgtggccgc
    13261 catgccgtgg agcgcggtat caaccggctc aaacgtcacc gggcggccgc gaccagaatc
    13321 gacaagctcg ccgtccgata ccaggccacc atccacatcg ccgcgatcaa cgaatggctg
    13381 tcacccgctt tgaaacacga cctagccgac acaccgtggg acgccgacat cgcagcgccg
    13441 ggcgacgacc cgaccctccg ggagacgacg ttcggtggtg gcagggggct gctgtcgttc
    13501 cggggcgatg acgatgccga gatggtccac gtgttcgcga tcgcctggat cggatagcgc
    13561 ttctcttgct actggaggcc ggacacgtcg cctatacacc ctccacccgg gcgcggccct
    13621 cgttgccgac gagggccgtc agagtgggtc gaggcgggcc ttgagcaggc agaactcgtt
    13681 gccttcggga tcggcgagga cgtgccaggg ctcttccccg gtctgaccga tgtcgacgag
    13741 ttcggccccg gcggccagga ggcgttcgag ctcggcgtcc tgatcacggt cggtggcgtt
    13801 gacgtcgatg tgcagccgga gtttcccgtt cttcggctcg tcgtcgcggc tgaggatgat
    13861 cgtcggctgc gggccgccga acccttcgcg cggccctatc tcgatatcgc cctcgtcgcg
    13921 atcgagcacc atgaagtcca ggacctcgca ccagaaccgc gccagcacct cggggtcgtg
    13981 gcaatcgagc accagctcac tgatacggca tgccattgac gaaacctact ctcagcgtgg
    14041 gaactgccgg ggtggccgcg cgcggatctc atgtgctccc tgtagtgaga acactttcgc
    14101 gaccgtaccg ggcgaggcga gcaggggcga ggtgatttca ggccctcgcc tggccgggcc
    14161 gtcaggcaag ggccgtaggt cgcccagtat cgaaggcgca cctggcccat ggttggttac
    14221 gatcacggcc ccactggctt tttctggccg ctgtgacacg tcggaagata cccttcgcgt
    14281 cctttgggct ggtgcggctg ggcgttcccg tgggcgggac tcctggtgat ggagggatat
    14341 tccgttgtgc gtccaggggc acggccataa ggtcaccggc atgtccttgc gagttcgtat
    14401 gcgtgaagcc ctgcccgaag cgatgcgcgc ccgggacagg gtcgcagtga gagtcctgcg
    14461 cgcaacgctc gccgcgctgg acaatgccga ggcggtgcct gcggatgaag ccgagctgcg
    14521 cggatcggcc atcgagcagt cgccggtcgg cgtcggcgtt tccgaggcag cgcggcggga
    14581 actgagcgag cgcaccgttg cggacatcgt gcaagccgag gccgccgaac ggctagaggc
    14641 tgcaatgcag ttgaccgcgc ccatgcacgc tgatcgcgcc gcgcagctcc gtgcggaggc
    14701 cgccgtgctg cttcggttcc tcgacggtgc tggcggcgtg taggactcgg taagagcgtc
    14761 gcgccgtatc ggggtcgatg caaggagttt gacccaccgc cagaggcact cgatgacact
    14821 ggtggcgccc cggtgatgat cggaaacgcg tcgtcggcgc cctccgcatc gtcgtcaccg
    14881 cctgatcggc catccggctt ggcgggggcc gcgcaggtgt cgagaccggg cggccgccgc
    14941 caggtgctgc gcgccgacgc ctaatcggcc gaggtcagcc agaagctctt gtcggagaac
    15001 tgcatgttgt cgagcctcat gacgagccga ccgtggtcgt cctcgttcgc ccagacacag
    15061 gtgatcggct catcatccgg tgacacgagc tggacttcgt ccatctcgca gcggacatgc
    15121 tcgctcttgg tcttgtagcg ggcgacatcc tcgaccgcac tgcggacgac gtggcgtccg
    15181 tcgactggct ccatctccga catgatcgag ccgatggaga cgtcccactt ggcgctgatc
    15241 ccgtccacgg tgacagtgca ggtgatgtcc tctgatgagc cgaacccgcc ggacccgctg
    15301 acctccgggc agtcagcttc tacaccgtcc ccgtaccagc gtgcatagac gctggtcgtc
    15361 tcgatgaggg accactcgac ccgctcgctg acgggagcgt ccttcgtcgg ttcgggaggc
    15421 agcccgctct tgtcgagttc gggagagtcc tccggcacag gaccggctcg cagttcatcg
    15481 aggttcggac ccgaacacgc acccagggcg agaacggttc cgagagcgaa tactccgtag
    15541 gacgctgacc ggaggggacg gactgggttg tggatcatca attcctttcc cggcatacaa
    15601 ggcaaacggt gattgtacgg ctgtttccgg gcgacgtcgg gaacggactg tgctcgtctc
    15661 cacgaacagg gccgcgactt catcggccgc gattccaccc agcgcccgcg ccatcaacgt
    15721 cgaggcggcg ttgggtgtcc acggcgtgtt gccagccccc aggtcagtgc tctcggggac
    15781 ctgagtccta agctcgtggt catggagcag cgaacgatct tcatcaccgg tgccagcgcg
    15841 ggtttcggcg cggcgatcgc gcgtcgtttc gccgccgagg gcgcccgtat cgtggccacc
    15901 gcgcggcgtg ccgaacggtt ggacgacctg cgcaaggagc tgggcgacga cgtcgtcctg
    15961 ccggtggcgc tggacgtgcg cgaccgggcg gccatcgagc gggtcgtgac tgacctgccg
    16021 cctgacttcg ccgacgtgga tgtgctggtg aacaacgctg gtctggcgct ggggctggag
    16081 cccgcgcatg aggctgatcc caatgactgg cagcggatgc tcgataccaa ttgcgccggg
    16141 ctgatgcact gcacgcgcgc cctgttgccg gggatggtgg agcgcggccg tgggcacgtc
    16201 gtcaacatgg ggtcgatcgc ggggagctac ccctatcccg gcggcaatgt ctacggcgcg
    16261 accaaggcgt ttgtgcagca gttcagccgg aacctgcggg ccgacctgct cggtaccggc
    16321 gtgcgggtga cctgcgtgga gcccggcctg gtcgggggca ccgagttctc cagtgtccgc
    16381 ttcggcggcg acagtgagcg cgccgcggcg ccctacacga acaccgaacc actgaccccg
    16441 gaggacatcg ccgagacggt gcactgggtc gtgtcgcagc cgccgcacgt caacgtgaac
    16501 gccgtcgagc tgatgccggt ttcccaggcc ttcggcccga tgcggatcca ccgcaccgag
    16561 tcgtaaaccg gggcctggct ccgaacaggg gcgcgtcggt ggtgcgacgg actcagtgtg
    16621 ctgcccggtc ggcgttgggg cggggcagtc cggcgcgctt gaaggtcgcc aggatcgggg
    16681 tggtctcgat gcccgtgacg tgtcgcagtc cgccgatcgt gtcggtcaac agcgagtaga
    16741 gcgcgtcgag atcggctgcg gccgcggcgg ccatgaggtt ggcgggtccg gtggtggcgg
    16801 cggtgaagtg gatctgcggg tgcctgctga gggcgtgtgc ggtcgcgtcc agcccaccgg
    16861 gtgccacggt catccacagc agtgcctcgg catggatgcc gaggagggcg aggtccacct
    16921 cggttgccaa ccgcaccacg cggtcggcca gcaggtcggt gcgtcggcgt gcggtgaggg
    16981 cggccgtccg tgcgcggcgg gccaattcgg tgtaggtggc ccgcccattg tcggccaggc
    17041 cccggataag cgcgtgatcg gtgtcgtcga gcgcgagccc gccgggcggt gacgccacct
    17101 cgcggcgcag tacctcggct tccgccggag acagcaggcc gccggtccag tcgaaggcgg
    17161 cggggaagac ccgcagcagg gtgtgggagg tccaggagtc gacggcctcc gtggcgggca
    17221 ggtcgcgcag caacagccgg ttgcgcgctt cgggcccgtc caggaagacg acggtgctga
    17281 tctcgtcgcc gccgctcaga acgtcgaccc agacggtatc cgggcgttcg gccaggaccg
    17341 cggcgacggc gcggatacgc cgcgggcggc agcggatgcg cagcgccatc gggatcagct
    17401 cggggaagca gccggggttg cgtaccgcgg tgacacgcac ggttccgtcc tgcagcagcg
    17461 gtcccgcgcg gcggacgacg gtgcgctccg agacgccgat cgtgtcggag acggtccgcc
    17521 atgaagcacg gggcgaggcc agcagggccg cgacgatccg ccgatcggtg tcgtccaagc
    17581 ggtggcgcat gatcagcatc ataggcggca tatctgtcgt gttttctgca gtaaagccgg
    17641 tgtttctggc gggtgatccg ggtgagccgg aggcttgccg tgacgtacgc ggccccggga
    17701 agcgggcctc gtgtcacggg agcgtgacgc gaagtccgcg ggccgatccc agagggaacg
    17761 gaggctcgga tgaacaggga agcgacggcc gatctcgtgg tgcgcgcggg cacggtgcac
    17821 accatggccg cagcggaacg accggtgacc gcgctggcgg tgcgccgggg ggagatcgtg
    17881 gccgtggccg cgccggagaa tgcacaggat ctgctggaga cctggagcgg gccgggcacg
    17941 acggtgctcg acgacccggg gctcgtcgta ctccccgcca tcgtcgacac ccacaaccat
    18001 ctgatgctgg ccgcacgcaa cagcctgggc gcgcccgtat cactggccca ggacatcccc
    18061 cggtttctcg aactgatccg cgagcgggcg gcccacacgc cttcgggcca gtggatcatc
    18121 accggcgccg actggcacga actgcatctg gccgaacgcc ggatgcccac cgccgaggaa
    18181 ctggaccggg ccaccaccga ccaccccgtc ctggtgctgc gcggtggcca caacggggtg
    18241 ctcaactccg ccgggctgcg cttggcgggc atcggccccg acacccccga cgttcagggc
    18301 ggctacattg cccgggacgc cgcagggcgc ccgaccggcc gggtccagga cgccgccctc
    18361 gaactcgccc agaaggcgct gcccgcgctg cccgccgggg cgctagccac gggcctggcc
    18421 cacgcgtcca ccgagtacgc ggcgcacgga atcggcagcg tgcgcgatcc cgccgtcacc
    18481 ccgcaggaat ggcacaccta tgtgcgggcc caggccgacg ggcggctgtc ggtccgcagc
    18541 cacgccatga tcctgtccac tccggcgtcc atcttcgccg ccggatcgat gggcgcctac
    18601 ctcgacgctc tggaagccca gggcatcacg cccgatgccg gccagggccg actgcgcctg
    18661 tggggcctca agttcatcct cgacggcggc gtcgaggcgg ccgcgctgga acgtccctac
    18721 gctgaccggc ccggctacca cggggacctg atgtgggacc gtgacgacct cgcccagtgc
    18781 ttggctgtct gcgtccggcg gggctggccc gtcggtacgc acgccttcgg cgaccgcgct
    18841 gtcgccgtgc tgctcgacgc catccgcgac gtggtcgggc aacacggtcc gatacccccg
    18901 ggtgcgctgg tgatcgaaca cggtggcctg atcggcggcg accagatcgc cgacgcggtc
    18961 gacctgggtg tacatataac cgtccagcat gccctgtcgg acgggctcgg cccggctctg
    19021 ctcgcttctt tcggccctga tcggacggcc gcattgtggc cactgcggga actggtcgac
    19081 tccggcgcct ggatcagcgc gggcaccgac caccccatcg gcccgctcga ccccctgcgc
    19141 tgtgtgcacg gcatgaccac ccggcacacc ccgacagggg tgcgcgggcc ggagcacgcc
    19201 atcgaccgcg ccgaggcact gcgcctctac accagctccg gggcacggtt gctcggccac
    19261 gcggccaccg gcaccctcgt ccccggcgca ccggccgaca tggtcgctta ccgggcggac
    19321 cccttcacct gtcccgcgga cgacctgctc cgcctcgcac ccgagatcac cgccgtcggt
    19381 ggcgaggtcg tgtaccggag agcgtgaagg ccgctgggtc gctgacgggc gccgggcctc
    19441 gccgcggtac gccgaggctg gtggaggaag ggcgttcaga tctgagagcg cgctcgtggc
    19501 tgccatcagc cgagactcaa tgccattaca gtacaaacgt acagtaaagt attgcagggc
    19561 tcctcttcct tctggttggg tgctcgacgg gagtggcaaa tgggcctacg ccgtcatggg
    19621 ctgaggtttt tggggtgtgg ctgtctgtga ctcggtgtct gatcagtgcg ggggaggaga
    19681 gtgatcgatg ctccttgtgc tcttgagtct cgggcgatcg atatatacag tacgaatgta
    19741 ctaaatgagg gtgggcggca gtccctgctc ctcggtctgg gcgtccttcc tcgctcctcg
    19801 ctgaggctct gccgaagttg caacgacccc gacggctacg tcgtcggggt tacgcagaaa
    19861 aaggagtggt gagcgacatg gcaagtacga cggataggac cgacacccaa gccgtgtccg
    19921 cgaaggcgcc ggtcgcgcgg gtcgcctcgt acgctttcgg gggccacgac ggcagagcac
    19981 tcgccgagtt ctacgccgcc gccctggggt gggaggtgac ccaggagttc cccgacgaga
    20041 acggtgtgcc ggtcgccttc atcgtcaccg acggcaccac catctacacc ttctacaccg
    20101 cccgtgactt ccgggcaccc aactggcccg aggatgagct gccgttccac ctggacctga
    20161 tgttcgatga cgtcgcggcg ggggagaagc gcttgctgga tctgggcgcc acgaggcccg
    20221 accaccagcc cggcggggag cactggacgg ttctgctcga tccgtccggc cagccgttct
    20281 gtatcagccc cgccaccaac tggcagtggt agcagcttcg cacgcagggc ggccgaacgt
    20341 ggagcgccgt gcctgaccgc ctcccgttgc agcgccctta acacgccgag cagcatcaga
    20401 ggccgtggcg gcggtgggta ggcacccctg gccgaaaaac tcgttgcgtc atatcgcgcc
    20461 aacgggttca atcagcgggc cggtccgcgc acagcgcggt ccggatacat gttcgccgac
    20521 acggaagtga gtgttgtctt atgcgcggta agcggtggtg tacaccccgg ccggcttcga
    20581 gcgccgtcgt cctccaggag ggcccgaacg cctgagccgg tgatgatgcc ggggaagggc
    20641 accccggtac gggcccttcg cgagggcggg atgcggcgct cggttccgac caccgccgga
    20701 tttctctcgc aaggagccac cactccgtgt ccagacgacg cgacgagcgc gcacgaccgc
    20761 gctccgggcg gaacgccgac gcgttccgct gcctgcactg ccgcctcgac gtgccgatga
    20821 gcgcgccggg aacacggcat cgcaaccact gcccgaactg tctgtacagc aggcatgtcg
    20881 accgagacat cccaggcgac cgcgccgccg agtgcggcgc ccggatggag ccgatcgcga
    20941 tctcggtgcg cggtgacggc gaatgggtga tcatccaccg ctgcaccgcc tgcgacgaac
    21001 tcggtgcgaa ccgcaccgcg ggcgacgaca atccgctgat gctggtgcgc atggccaccc
    21061 gtcccctggc ggcaccgccg ttccccctgg agcggctcgc cgcgctgtag cgggtcccgc
    21121 gccatcttgc ccatggccgc ccgggaacga ttccgatccc gggcggccgg ttcgataggg
    21181 cacgaccggc agccgtgacc ggggga
//
