LOCUS       NZ_CP022753            10426 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Nocardiopsis gilva YIM 90087 chromosome, complete genome.
ACCESSION   NZ_CP022753
VERSION     NZ_CP022753.1
KEYWORDS    RefSeq.
SOURCE      Nocardiopsis gilva YIM 90087
  ORGANISM  Nocardiopsis gilva YIM 90087
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     The complete genome sequence of Nocardiopsis gilva YIM 90087
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2017) Yunnan University, School of Medicine, 2
            North Cui Hu Road, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 208.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002263495.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 21:04:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,549
            CDSs (total)                      :: 5,470
            Genes (coding)                    :: 5,345
            CDSs (with protein)               :: 5,345
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 61 of 125
            Pseudo Genes (incomplete)         :: 66 of 125
            Pseudo Genes (internal stop)      :: 5 of 125
            Pseudo Genes (multiple problems)  :: 6 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1182971
            Orig. end                         :: 1193397
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10426
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="9"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10426
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10426
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5426](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5426
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    complement(549..564)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.09"
                     /tool="antismash"
     misc_feature    complement(767..776)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            complement(781..1422)
                     /locus_tag="CDO52_RS05670"
                     /old_locus_tag="CDO52_05655"
     CDS             complement(781..1422)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622854.1"
                     /locus_tag="CDO52_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05655"
                     /product="copper resistance CopC family protein"
                     /protein_id="WP_094932232.1"
                     /transl_table=11
                     /translation="MPHTFTARRSAVTLASLTASLLLGIGLAPAALAHNALIDSSPKDG
                     AKLDKAPEEVTLTFNADVNDGGNAIVVTGPDGDTYEEGDVRLDGPTAATDLRPLDAAGE
                     YTIAYRIVSADGHPLEEKLTFSVSEEAVADNEAAAEDADTAAPSPDDTAGSDTQDGTST
                     DEGEPAASSDPMQSLGPVGAVIGGIAIIALIVILIIRMRGRQGGQDGADS"
     gene            complement(1457..2101)
                     /locus_tag="CDO52_RS05675"
                     /old_locus_tag="CDO52_05660"
     CDS             complement(1457..2101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017610127.1"
                     /locus_tag="CDO52_RS05675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05660"
                     /product="hypothetical protein"
                     /protein_id="WP_026126328.1"
                     /transl_table=11
                     /translation="MRSPGGGPLRVIRTAVLAVACTGLAWGGHAVWAGSPIAPGAFAAA
                     TALMAVLLVRFTRCQRGFCEIFTVLAAAQVGLHLVFQGLSAASPTAAGEHSAHPAPGHG
                     SAPLTHALGVVGFSPGMLAGHLWAALLAAALLAHGERCLWTLLRLLTAALPPLLPPAVL
                     PIADPRTGAPDPTPARPSPRMLRRERTRGPPSPAERLQLRIDALHARPHTI"
     gene            complement(2203..2466)
                     /locus_tag="CDO52_RS05680"
                     /old_locus_tag="CDO52_05665"
     CDS             complement(2203..2466)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017616169.1"
                     /locus_tag="CDO52_RS05680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05665"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_094932233.1"
                     /transl_table=11
                     /translation="MNRLYHESEDWVAQGACRQYDPELFFPVSTTGPGQHDAELAKAVC
                     RSCTVRQECLRWALAAGEAHGVWGGTSPEERRYMRRELAPAS"
     misc_feature    2654..2668
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.78"
                     /tool="antismash"
     misc_feature    complement(2702..2719)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.23"
                     /tool="antismash"
     misc_feature    complement(2750..2765)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.3"
                     /tool="antismash"
     misc_feature    complement(3086..3095)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    complement(3152..3170)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.17"
                     /tool="antismash"
     gene            3608..4873
                     /gene="ectB"
                     /locus_tag="CDO52_RS05685"
                     /old_locus_tag="CDO52_05670"
     CDS             3608..4873
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-357). E-value: 5.2e-74.
                     Score: 241.2. Matches aSDomain:
                     nrpspksdomains_CDO52_RS05685_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017558126.1"
                     /locus_tag="CDO52_RS05685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05670"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_017621329.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.7e-74, bitscore:
                     249.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIFDRLESEVRSYCRSWPVVFNEARGSYIYDESGRPYLDFFAGA
                     GSLNYGHNNPVLKSKLIDYLASDGVVHSLDAYTTAKQEFLQTFGDVILGPRGLDYKVQF
                     PGPAGNNAVEAALKLARKITGREVIVNFTNSFHGMTLGALAVTGNSMKRGGAGVPLTHV
                     NTMPYDNYMDGETPDFLWLRSVLEDSGSGLDKPAAVIVETVQGEGGINAASAEWLRGLA
                     ALCEEHGILLIVDDIQMGCGRTGGFFSFEEAGIKPDIVTLSKSISGYGIPLALTLFKRE
                     LDVWGPGEHNGTFRGPNPAFVTGTAALDTFWRDDELQKATLAKGELIRTRLTAIAEEFA
                     EAGAHVRGRGMAAGLAFEREGAASALSREAFQRGLLVETSGPEDEVAKLLPALTTTEEE
                     LEQGLDIMAEAARAAVKISQPA"
     aSDomain        3674..4678
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CDO52_RS05685_Aminotran_3.1"
                     /evalue="5.20E-74"
                     /label="CDO52_RS05685_Aminotran_3.1"
                     /locus_tag="CDO52_RS05685"
                     /protein_end="357"
                     /protein_start="22"
                     /score="241.2"
                     /tool="antismash"
                     /translation="NEARGSYIYDESGRPYLDFFAGAGSLNYGHNNPVLKSKLIDYLAS
                     DGVVHSLDAYTTAKQEFLQTFGDVILGPRGLDYKVQFPGPAGNNAVEAALKLARKITGR
                     EVIVNFTNSFHGMTLGALAVTGNSMKRGGAGVPLTHVNTMPYDNYMDGETPDFLWLRSV
                     LEDSGSGLDKPAAVIVETVQGEGGINAASAEWLRGLAALCEEHGILLIVDDIQMGCGRT
                     GGFFSFEEAGIKPDIVTLSKSISGYGIPLALTLFKRELDVWGPGEHNGTFRGPNPAFVT
                     GTAALDTFWRDDELQKATLAKGELIRTRLTAIAEEFAEAGAHVRGRGMAAGLAF"
     gene            5001..5426
                     /locus_tag="CDO52_RS05690"
                     /old_locus_tag="CDO52_05675"
     CDS             5001..5426
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621330.1"
                     /locus_tag="CDO52_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05675"
                     /product="ectoine synthase"
                     /protein_id="WP_017621330.1"
                     /sec_met_domain="ectoine_synt (E-value: 8.9e-54, bitscore:
                     179.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLKDVDGTDADVQTENWRSRRIILAKEGVGFSFHETVLYAG
                     TETSMWYANHVELVHCIEGEAELTNDETGEKFTITPGTLYLLNGHEKHTIRPKTDFRVL
                     CVFNPPVTGREVHDENGVYPLLTEEDDSAKESLATAE"
     gene            5619..6527
                     /gene="thpD"
                     /locus_tag="CDO52_RS05695"
                     /old_locus_tag="CDO52_05680"
     CDS             5619..6527
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621331.1"
                     /locus_tag="CDO52_RS05695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05680"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_033302056.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-35, bitscore: 122.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALTTDFEQPTMDDYPTRKDGFPSLLYRRDAVVLGEGDGPIDRA
                     TLDSYDDKGYLQVEQLLTPEELEKYRAELRRLSEDPELRKDERVIVERQSDEVRSIFEV
                     HKISDVIAELVRDPRVVGRARQILGSDVYVHQSRVNSKPGFSGSDFFWHSDFETWHAED
                     GMPRMRAVSISIALTDNYEHNGSLMIMPGSHKTFVSCVGETPENHYKASLKQQEVGTPD
                     QDSLSILAAKHGIDVLTGPAGGAIMFDSNCMHGSSGNITPFPRSNIFIVFNSVENTCGE
                     PFAAPTPRPPFLGARDFTPVV"
     gene            6822..7724
                     /gene="ehuB"
                     /locus_tag="CDO52_RS05700"
                     /old_locus_tag="CDO52_05685"
     CDS             6822..7724
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033294 - ectoine binding [Evidence IEA]"
                     /GO_function="GO:0033295 - hydroxyectoine binding [Evidence
                     IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188113.1"
                     /locus_tag="CDO52_RS05700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05685"
                     /product="ectoine/hydroxyectoine ABC transporter
                     substrate-binding protein EhuB"
                     /protein_id="WP_232524391.1"
                     /transl_table=11
                     /translation="MTTIRGSGMDRRRFLARTGGAAVAALMGPTLLSGCSRVGTGNTFD
                     RVREQGYINVGFANEAPYGYTDLATGKLTGESPELARAIFAELGVDDLRGVPVSFDGLI
                     PGLIGGQFDMVAAGMAIVPDRCRQVAFTNPDYLSRTAFLVPEGNPAGIENFSSIAENPD
                     ITLAVMNATVEQQMAAQAGVPTAQVQTAPDTPSAYELLETGRIDAVALTAISLRWILKT
                     RGGPFEVTEAFFPVVDGQEVIGGGGYALRQEDTDMLAAFNEKLEEFKESGRLLEIIEPF
                     GFSEDELPGDLTAQQLCSA"
     misc_feature    6912..6914
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7741..8469
                     /gene="ehuC"
                     /locus_tag="CDO52_RS05705"
                     /old_locus_tag="CDO52_05690"
     CDS             7741..8469
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuC"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621333.1"
                     /locus_tag="CDO52_RS05705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05690"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuC"
                     /protein_id="WP_017621333.1"
                     /transl_table=11
                     /translation="MTFFTDSLPLYLNGAWYTLLITLGGCALAFVISMVVGIVGAMRNP
                     WALAAATVYVEVFRGVAALVLMFWLFYAMPLVTGYRLEPVFAAILALGLNVGAYGAENV
                     RGAINAVPKAQYEATIALNFSAFQRMRRCILPQAWAQMLPTFGNLAIELMKGSAVVSLI
                     AVSDITFVAQQLRTFSGETLLAFASALVMYFVIAQLIVFFVRMAERRANRRLGRLPAPA
                     KPSWVARALISAGREKEGAA"
     gene            8469..9119
                     /gene="ehuD"
                     /locus_tag="CDO52_RS05710"
                     /old_locus_tag="CDO52_05695"
     CDS             8469..9119
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuD"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621334.1"
                     /locus_tag="CDO52_RS05710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05695"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuD"
                     /protein_id="WP_017621334.1"
                     /transl_table=11
                     /translation="MFDWGFVGEALPDLLTGLRYTLLATAFGYVLALVLGLVVAMTRRA
                     APRPIAAVVFWVMEFIRSTPLLVQLFFIFYVLPGIGISLSPLTAGVIGLGVHYAAYTAE
                     VYRSGMEGVPKGQWEAARALSLPVRRTWSAVVLPQAIRRVIPALGNYLIAMFKDTPLLF
                     AITVPEMMFEANRLGGTHFKYLETISAVGVLFIIVSALSAVLIRTLERRYAAV"
     gene            9106..9993
                     /gene="ehuA"
                     /locus_tag="CDO52_RS05715"
                     /old_locus_tag="CDO52_05700"
     CDS             9106..9993
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621335.1"
                     /locus_tag="CDO52_RS05715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_05700"
                     /product="ectoine/hydroxyectoine ABC transporter
                     ATP-binding protein EhuA"
                     /protein_id="WP_017621335.1"
                     /transl_table=11
                     /translation="MPRSDDNHTNRPDAESDAGAVPHARAENGQSGGGDDQPLIRFEKV
                     VKRYGDNVVLRELDFAVDAGQRVTLIGPSGSGKTTILRLLMTLERINGGVIWVNGDPLS
                     HMYKSGDGGELVPATEKYQREVRKKIGMVFQQFNLFPNMSVRRNITEAPVYSLGISRDE
                     ADQRAEELLEMVGLSDKIDAHPTRLSGGQQQRVAIARALAMRPEILLLDEVTSALDPEL
                     VAGVLDVLREIARTTDITMLSVTHEMGFARDVSHRVLMFDQGQILEEGPPEQIFGDPQE
                     ERTKSFLHAVLESS"
     misc_feature    10061..10071
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(10290..10303)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.91"
                     /tool="antismash"
ORIGIN
        1 accgccgcgt catcaacgcc gtgctgttcc gaacccgcac cgggatcccc tggcgtgacc
       61 tgcccgaacg ctacggcccc tgggagaccg cggccgggcg ccaccgccgc tggtgcctgg
      121 acggcacctg gcaaaggatc gccgaccggc tgcgcatcga cgccgccacc ggagaagacc
      181 tggtggtcgg catcgactcc accagcgtgc gcgcccactc ccacgccgcc ggagccgcga
      241 aaaaggggaa gcggtacggg acgaagcgga cggctcggaa gcactgggac gttcccgggg
      301 cgggctgacc accaagatcc acctgatcgc cgaccagcgc aggcggccgc tggtgaccgc
      361 gaccagcccc ggccagcgcg gtgacgcgcc catgttcgag ccgctgatgg tcgccctgca
      421 cctgccccgc tcggtcgggc gcccccggac caggcccgac cggctgctcg cggacaaggc
      481 ctactcctca gcggcgatcc gctcccacct gagcaggcgc ggtatcaagg cgaccattgc
      541 ccagcccgcc gaccagcggg ccaatcgcag gcgcagggga tcggcgggcg gtcggccccc
      601 ggctttcgac cggggtgcct accgcggccg caacactgta gaacgggcga tcaacctgct
      661 caagcagaac cgggccgtgg ccaccaggta cgacaagcgc gccgcgatct acgacgggac
      721 cgtccagctc gcctcgatac ggatctggct acgcgacctc acccgttcga aaaacactgc
      781 ctagctgtcc gcgccgtcct ggccgccctg acggccgcgc atgcggatga tcaggatgac
      841 gatcagcgcg atgatcgcga ttccgccgat gaccgcgccc acggggccca gcgactgcat
      901 cgggtcgctg gacgcggcag gctcgccttc gtcggtggaa gtgccgtcct gggtgtcgga
      961 gcccgccgtg tcgtccgggc tgggcgcggc ggtgtccgcg tcctcggccg ccgcctcgtt
     1021 gtcggcgacg gcctcctcgg agacgctgaa cgtgagcttc tcctccagcg ggtggccgtc
     1081 ggcggagacg atccggtagg cgatcgtgta ctcgcccgcg gcgtcgaggg gccggaggtc
     1141 ggtcgcggcc gtggggccgt cgagccggac gtcgccctcc tcgtaggtgt cgccgtccgg
     1201 gcccgtgacg acgatggcgt tgccgccgtc gttcacgtcg gcgttgaagg tgagcgtgac
     1261 ctcctcgggg gccttgtcga gcttcgcgcc gtccttcggt gaggagtcga tgagcgcgtt
     1321 gtgcgccagg gccgctggag ccaggccgat gcccagcagt agggaggccg tgagcgaggc
     1381 gagcgtgacg gcgctgcgtc gcgccgtgaa cgtgtgaggc atggggtgag gtgacctttc
     1441 cggccgttgg tatccgtcag atggtgtggg gacgcgcgtg gagcgcgtcg atcctgagtt
     1501 ggagacgctc agccggtgac ggcggccccc gggtgcgctc gcggcgcagc atgcgcgggc
     1561 tcggtcgtgc gggggtcggg tcgggtgcgc cggtgcgcgg atcggcgatc gggaggaccg
     1621 cgggcggtag caggggcggc agggcggcgg tcagcagccg caggagagtc cacaggcacc
     1681 gctcaccgtg cgcgaggagg gcggccgcca ggagcgccgc ccacaggtgc ccggccagca
     1741 tgccggggga gaagcccacg acaccgaggg cgtgggtgag cggggccgat ccgtggcccg
     1801 gcgctgggtg ggcgctgtgc tcccccgcgg cggtgggaga ggccgcactc aggccctgga
     1861 agacgaggtg caggccgacc tgggccgcgg cgaggacggt gaagatctcg cagaacccgc
     1921 gctggcaccg ggtgaaccgg accagcagca cggccatgag ggcggtggcc gcggcgaagg
     1981 cgccgggggc gatgggcgaa ccggcccaga ccgcgtgccc accccaggcc aggccggtgc
     2041 acgccacggc gagcaccgcc gtgcgtatga cccggagggg gccgccacct ggggaccgca
     2101 cgactcccga acctaaccga gaacatcggt ggcgtgaagc cgccggcggg tcgtccacga
     2161 ccccgccggc ggcttcacgc cacctaccgc cggaaccgcg gatcagctgg cgggtgccag
     2221 ctcgcggcgc atgtagcggc gctcctcggg gctggtcccg ccccacacgc cgtgcgcctc
     2281 tccggcggcc agcgcccacc gcaggcactc ttggcgaaca gtacagctgc ggcagacggc
     2341 cttggcgagc tccgcgtcgt gctgccccgg cccggtcgtg ctcaccggga agaacagctc
     2401 cgggtcgtac tgtcggcagg ctccctgcgc gacccagtct tcgctttcgt ggtagaggcg
     2461 gttcaccagg cgccctccgt tccctggctc gatgtccggt ggggcgagac ggagctccac
     2521 cggcctgttg agacctcgca tgtcgagacc cgtgcgcgtt gagactcccg cgcgacgaca
     2581 tgcgcgagac cgcgtagacg agcttcagcg cgccgcgacc gattgtagta ctacgaagag
     2641 tcgtactacg caaagtctgc taaaaattcg gctccctttc aaggtgccga agagctcctt
     2701 ggtcacagtc gcataacgtg cgcgtcacga aaaagacttc gtcccgtcgg ataatgtttc
     2761 gcgatattcg gtccggcccc cgttggggtc tgatccgcgc gctggtgggt ccttccgcac
     2821 gtcgggtgga gcgatcaatg cctgtctcgg ctctgtcgcg accattcacc cgaatttgtg
     2881 tgaggtagcc cacccttaag atttgctgcg cttgctctat gtttgaacgg cgataggcgg
     2941 gatactcgtc atgtccctcc cgctcgcggg gtccggaacc ggcccggatc gcgttccgaa
     3001 accgctggtg agtacggcgt ctgcgggggg tgagcgggtg cggactgaag cccccgcgat
     3061 ggcgacggat tgtgacggta ggcgctaaat aaacaagccc tacccgagga aacgggctcg
     3121 aaacatagtt tccgcagcca cgaaaaacgc tgctcaggaa cgttcgctat gttccttcga
     3181 cgtgcctcat acacagatcg acgccggaac ccgcggccga ccggacaccg gggatcaccc
     3241 cgcagtagtc agtctcaccg tgggtcccgt tcgcatgcgc tcgatctgtc gtgtcggcgc
     3301 cgatagtgcc gcacgcgtcc ccgcgacgac agagggcact cccgcaccgg gcgacttcgg
     3361 ctcccgcgcc ccttccgctc ttttggcgcg ggagcgcgga gcggcccatg ccgcaccggt
     3421 gcggaccctg aacttcgaca cccagcagtg gccgcaggag gtccccaagg gacgcgtccc
     3481 cggggaaccc gtgcggctcg gcccgctatc cgctacgcga cgggccacga ccaaccatcc
     3541 gtcctgacca ccccgtcgtc accgccccga gcccacgaac ctggggaaag gaaccaagga
     3601 acacacgatg gagatcttcg accgcctcga atccgaagtc cggagctact gccgtagttg
     3661 gccggtcgtc ttcaacgagg cgcgaggcag ctacatctac gacgagtcgg ggcggcctta
     3721 cctcgacttc ttcgcgggtg ccggttccct gaactacggg cataacaacc cggtcctgaa
     3781 atccaaactc atcgactacc tcgcgagcga cggcgtcgtg cacagcctcg acgcctacac
     3841 cacggcgaag caggagttcc tgcagacgtt cggtgacgtc atcctgggcc cgcgcgggct
     3901 cgactacaag gtgcagttcc ccggcccggc cgggaacaac gccgtcgagg ccgccctcaa
     3961 gctggcccgg aagatcaccg gccgcgaggt catcgtcaac ttcaccaaca gcttccacgg
     4021 catgacgctg ggcgcgctcg ccgtgaccgg caactcgatg aagcgtggcg gcgcgggggt
     4081 gccgctgacg cacgtcaaca ccatgccgta cgacaactac atggacggcg agacgccgga
     4141 cttcctgtgg ctgcgcagcg tccttgagga cagcggcagt ggcctggaca agccggccgc
     4201 cgtcatcgtc gagacggtgc agggcgaggg cggcatcaac gccgccagcg ccgagtggct
     4261 gcgcgggctc gccgccctgt gcgaggagca cggcatcctg ctcatcgtcg acgacatcca
     4321 gatgggctgc gggcgcaccg gcggcttctt cagcttcgaa gaggccggca tcaagccgga
     4381 catcgtcacg ctgtccaagt cgatcagcgg ctacggcatc ccgctcgccc tcacgctgtt
     4441 caagcgtgag ctggacgtgt ggggcccggg cgagcacaac gggaccttcc gtggccccaa
     4501 ccccgccttc gtcaccggca ccgccgcgct cgacacgttc tggcgcgacg acgagctgca
     4561 gaaggccacc ctcgccaagg gtgagctcat ccgcacgcgc ctcaccgcca tcgccgagga
     4621 gttcgccgag gccggggcgc acgtgcgtgg ccgcggcatg gcggccggcc tggccttcga
     4681 gcgtgagggc gccgcctcgg cgctcagccg cgaggccttc cagcgcggcc tgctcgtcga
     4741 gacctccggt cccgaggacg aggtcgccaa gctcctcccc gcgctcacca cgaccgagga
     4801 ggagctggag cagggcctgg acatcatggc cgaggccgcg cgcgccgcgg tgaaaatctc
     4861 gcagcccgca taaagccact gcgcaggcgc ggcccgagcc gcacaattgc agtggatgaa
     4921 cacccgaggg tcccggcgtg tcgccgggac cccgcgttcg gtcgctcgcg gccgaaacga
     4981 gtcatgagga gtacaagagc gtgatcgttc gcagcctgaa ggacgtcgac ggcaccgacg
     5041 ccgatgtcca gaccgagaac tggcgcagcc gccggatcat ccttgccaag gagggcgtgg
     5101 gcttctcgtt ccacgagacc gtcctgtacg cggggacgga gacgagcatg tggtacgcga
     5161 accacgtcga gctcgtgcac tgcatcgagg gcgaggccga gctcaccaac gacgagaccg
     5221 gggagaagtt caccatcacc ccgggcacgc tctacctgct caacgggcac gagaagcaca
     5281 ccattcggcc caagaccgac ttccgggtgc tgtgcgtctt caacccgccg gtgaccggtc
     5341 gcgaggtgca cgacgagaac ggtgtctacc ccctgctgac cgaagaggac gacagcgcca
     5401 aggagagcct ggccacggcc gagtagcgcg tggtgcgggt gcgggcgcgc cgacccgcgc
     5461 gcccgcaccc gccctcaccc cctcctcctg gtgggagcga gtgtgcggac caccggaata
     5521 gggcaccctc gttgagcagg gaagaaaaga aaagagcctg acccgcaaga agcacacgat
     5581 cgagagcgcg aaggagagag accccgaggg gtatagccat gactgcgttg acgaccgact
     5641 tcgagcagcc gaccatggac gactacccga cccgcaagga cggtttcccg tccctgctct
     5701 accggcggga cgccgtggtc ttgggcgagg gagacggccc aatcgaccgc gccacgctgg
     5761 actcctacga cgacaagggc tacctgcagg tcgagcagct gctcacgccc gaggaactgg
     5821 agaagtaccg cgccgagctg cgccgcctca gtgaggaccc ggagctgagg aaggacgagc
     5881 gcgtcatcgt cgagcggcag tccgacgaag tccggtccat cttcgaggtc cacaagatca
     5941 gcgacgtcat cgccgaactg gtccgtgacc cgcgcgtcgt cggccgcgcc cggcagattc
     6001 tgggcagcga cgtctacgtg caccagagcc gcgtcaactc caagcccggg ttcagcggca
     6061 gcgacttctt ctggcactcc gacttcgaga cctggcacgc cgaggacggg atgccccgga
     6121 tgcgcgcggt gagcatctcc atcgcgctca ccgacaacta cgagcacaac ggctcgctga
     6181 tgatcatgcc gggctcgcac aagacgttcg tctcctgtgt cggcgagacc ccggagaacc
     6241 actacaaggc gtccctgaag cagcaggagg tcggcacgcc cgaccaggac agcctgtcga
     6301 tcctcgccgc caagcacggc atcgacgtgc tcaccggtcc cgccggcggc gccatcatgt
     6361 tcgactccaa ctgcatgcac ggttccagcg gcaacatcac gccgttcccg cggtcgaaca
     6421 tcttcatcgt gttcaacagc gtggagaaca cctgcgggga gcccttcgcg gcgcccacgc
     6481 cccgcccgcc gttcctcggc gcgcgcgact tcactcccgt ggtctgattc gggacggcgg
     6541 ccccggccgc gtttttgatc gttattggcc ggacccggcc gtaactagtg cataacgcgg
     6601 gatttcgctt gtgctgaaag cggcaaagaa taagccgcac atttacgcag acaagcgcca
     6661 tgcgcgggcc cacggcctgc cgacgtgaca tcggaggtgc cctgaggcga ccctgagcac
     6721 gggcggacct ccggcgttca cgcacgtaca tcccgcacga cagcacggcg ctccctccgg
     6781 tgcaggaggg ggcgccgtgc tcgttcctga ggagacacga gatgacgacg atcagaggaa
     6841 gcggcatgga ccggcgccgc ttcctggcga gaacgggcgg ggccgcggtg gccgcgctga
     6901 tggggccgac gttactcagc ggctgctccc gcgtcgggac cggaaacacc ttcgaccgcg
     6961 tccgggagca gggctacatc aacgtcggct tcgccaacga ggccccctac ggctacaccg
     7021 acctggccac cggcaagctc acgggggagt cgcccgagct ggcccgcgcg atcttcgccg
     7081 agctgggcgt cgacgacctc cgcggcgtcc ccgtcagctt cgacggcctg atccccgggc
     7141 tcatcggcgg ccagttcgac atggtcgccg cggggatggc catcgtcccc gaccgctgcc
     7201 ggcaggtggc gttcaccaac cccgactacc tcagccgcac cgccttcctg gtccccgagg
     7261 gtaaccccgc cggtatcgag aacttctcgt cgatcgccga gaaccccgac atcaccctcg
     7321 cggtcatgaa cgcgaccgtc gaacagcaga tggccgccca ggccggagtc cccaccgccc
     7381 aggtgcagac cgcccccgac acccccagcg cctacgagct gctggagacc ggacgcatcg
     7441 acgcggtcgc gctgaccgcg atctcgctgc gctggatcct caagacccgc ggcggaccct
     7501 tcgaggtgac cgaggcgttc ttcccggtcg tcgacggtca ggaggtcatc ggcggcggcg
     7561 gatacgcgct gcgccaggag gacaccgaca tgctcgcggc cttcaacgag aagctggagg
     7621 agttcaagga gagcgggcgg ctgctggaga tcatcgagcc gttcgggttc tccgaggacg
     7681 agcttcccgg cgacctcacg gcccagcagc tgtgttcggc atgaaccccg gggagccgca
     7741 atgactttct tcaccgactc acttccgctc tacctcaacg gcgcctggta cacgctgctc
     7801 atcacgctcg gcgggtgcgc gctcgcgttc gtgatctcga tggtcgtcgg catcgtcggc
     7861 gcgatgcgca acccctgggc cctcgccgcc gccacggtct acgtcgaggt gttccgcggc
     7921 gtcgccgcgc tcgtgctgat gttctggctc ttctacgcca tgccgctggt caccgggtac
     7981 cggctggaac cggtgttcgc cgcgatcctg gcgctgggcc tcaacgtggg cgcctacggc
     8041 gcggagaacg tgcgcggcgc catcaacgcc gtgcccaagg cgcagtacga ggcgaccatc
     8101 gcgctcaact tcagcgcgtt ccagcgcatg cgccggtgca tcctcccgca ggcgtgggcg
     8161 cagatgctgc ccacgttcgg caacctcgcc atcgaactga tgaagggcag cgccgtggtc
     8221 tcgctgatcg cggtctccga catcaccttc gtcgcccagc agctgcgcac gttctccggt
     8281 gagacgttgc tggcgttcgc cagcgcgctg gtcatgtact tcgtgatcgc ccagctgatc
     8341 gtgttcttcg tgcgcatggc cgaacggcgg gccaaccggc gcctcggccg cctgcccgca
     8401 ccggccaaac cgtcgtgggt ggcgcgggcg ctgataagcg cggggcgtga gaaggaaggg
     8461 gcggcctgat gttcgactgg ggattcgtcg gcgaggcact gcccgacctg ctcacgggac
     8521 tccgctacac cctgctggcc acggcgttcg gttacgtgct ggcgctggtg ctcggcctgg
     8581 tggtcgcgat gacccgccgg gccgcgccgc ggccgatcgc cgcggtggtc ttctgggtca
     8641 tggagttcat ccgctccacg cccctgctgg tgcagctctt cttcatcttc tacgtgctgc
     8701 cgggcatcgg gatctcgctg agcccgctga ccgccggtgt catcgggctg ggcgtgcact
     8761 acgcggccta caccgccgag gtctaccgct ccgggatgga gggcgtcccc aagggccagt
     8821 gggaggccgc ccgggcgctc agcctgccgg tgcggcgcac ctggtcggcg gtggtcctgc
     8881 cgcaggcgat ccgcagggtg atcccggccc tgggcaacta cctgatcgcg atgttcaagg
     8941 acacgcccct gctgttcgcc atcaccgtgc ccgagatgat gttcgaggcc aaccgcctcg
     9001 gcggcacgca cttcaagtac ctggagacga tctccgccgt cggcgtgctg ttcatcatcg
     9061 tcagcgcgct gtccgccgtc ctgatccgaa ccctggagcg acgctatgcc gcggtctgac
     9121 gacaaccaca ccaaccgtcc cgatgccgaa agcgacgcgg gtgcggtccc ccatgcgcgc
     9181 gccgagaacg ggcagagcgg gggaggcgac gaccagccgc tgatccgctt cgagaaggtc
     9241 gtcaagcggt atggcgacaa cgtggtgctc cgcgagctcg acttcgcggt cgacgccggg
     9301 cagcgggtga ccctcatcgg ccccagcggg tcgggcaaga ccaccatcct gcggctgctg
     9361 atgacgctgg agcgcatcaa cggcggcgtc atctgggtga acggcgatcc cctcagccac
     9421 atgtacaagt cgggggacgg cggcgagctg gtcccggcca ccgagaagta ccagcgcgag
     9481 gtccgcaaga agatcgggat ggtcttccag cagttcaacc tgttcccgaa catgagcgtg
     9541 cggcgcaaca tcaccgaggc gcccgtctac agcctgggga tatcccggga cgaggcggac
     9601 cagcgggccg aggagctgct ggagatggtc gggctgagcg acaagatcga cgcccacccc
     9661 acgcggctgt ccggtggcca gcagcagcgg gtggcgatcg cgcgggcgct ggcgatgcgc
     9721 ccggagatcc tgctgctcga cgaggtcacc tcggcgctgg acccggagct ggtggccggc
     9781 gtgctggacg tgctgcgcga gatcgcgcgc accacggaca tcacgatgct ctcggtgacc
     9841 catgagatgg ggttcgcccg cgacgtctcg caccgggtgc tgatgttcga ccagggccag
     9901 atcctggagg aggggccgcc cgagcagatc ttcggcgacc cgcaggagga gcgcaccaag
     9961 tccttcctgc acgcggtgct ggagagcagc tgagcccggg agggcggcgg acgcggcgtg
    10021 cccgccgccg acgccgccct ccacgctcgg acgccggatg tgccatgcca ccctggatgc
    10081 atggcacgcc tgctcatcgt tcaccacacg ccgtctccgt ccatgcagac cctgctcgaa
    10141 tcggtgctgg agggcgcgcg caacgacgag atcgagggcg tcgaggtggt gacgcgcccg
    10201 gcgctcggag ccaccgtgcc cgacgtgctc gcggcggacg ccgtcatcgt cggcaccacc
    10261 gcgaacatcg gctacatggc cggcgccgtc aaacatttct tcgacaccgt gtactacccc
    10321 tgcctgaccg acacgaccgg gctgccctac gccctttacg tacacggcaa caacgacacc
    10381 accggggccg tgcgcgcggt ggaggccatc gccaagggga tgtcgt
//
