LOCUS       NZ_CP022753            20756 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Nocardiopsis gilva YIM 90087 chromosome, complete genome.
ACCESSION   NZ_CP022753
VERSION     NZ_CP022753.1
KEYWORDS    RefSeq.
SOURCE      Nocardiopsis gilva YIM 90087
  ORGANISM  Nocardiopsis gilva YIM 90087
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     The complete genome sequence of Nocardiopsis gilva YIM 90087
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6142152)
  AUTHORS   Yin,M. and Tang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2017) Yunnan University, School of Medicine, 2
            North Cui Hu Road, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 208.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002263495.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 21:04:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,549
            CDSs (total)                      :: 5,470
            Genes (coding)                    :: 5,345
            CDSs (with protein)               :: 5,345
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 61 of 125
            Pseudo Genes (incomplete)         :: 66 of 125
            Pseudo Genes (internal stop)      :: 5 of 125
            Pseudo Genes (multiple problems)  :: 6 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1001360
            Orig. end                         :: 1022116
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20756
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="8"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20756
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20756
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10756](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10756)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            complement(1140..1445)
                     /locus_tag="CDO52_RS04870"
                     /old_locus_tag="CDO52_04860"
     CDS             complement(1140..1445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017538647.1"
                     /locus_tag="CDO52_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04860"
                     /product="pore-forming ESAT-6 family protein"
                     /protein_id="WP_017621224.1"
                     /transl_table=11
                     /translation="MSGNGRNSYDLGASQESQTNIHAVMSRLESLIGEHDVDVSKAMAD
                     FEATGVSDEYSEKELKWHNAGNEVRDIIRLVRETLETNDGTAQSTLGRASAAVQGI"
     gene            complement(1517..1852)
                     /locus_tag="CDO52_RS04875"
                     /old_locus_tag="CDO52_04865"
     CDS             complement(1517..1852)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621223.1"
                     /locus_tag="CDO52_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04865"
                     /product="hypothetical protein"
                     /protein_id="WP_017621223.1"
                     /transl_table=11
                     /translation="MSRWDFGDQTLTTLARSTSGATDELSNLITQLIQAAEPLSGKFNG
                     AGKAAFDSFKARADGITADLNSGLGRVNEGQYGMQSAFSSGNQNMADDANRNMSAANFD
                     AAKFRTA"
     gene            2100..2438
                     /locus_tag="CDO52_RS27185"
     CDS             2100..2438
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157745427.1"
                     /transl_table=11
                     /translation="MKFQQVDPGEWDSAEPSAAAEGRPAPDVSSGTPDSAEQMDPAARL
                     SAAASLLTCDIGRDAASASESIAALMQRIADRNRKSTDFGHPAPPPPPTTFRADRFAGS
                     PPPEGASD"
     misc_feature    2443..2452
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            2478..3370
                     /locus_tag="CDO52_RS04880"
                     /old_locus_tag="CDO52_04870"
     CDS             join(2478..3186,3186..3370)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558180.1"
                     /locus_tag="CDO52_RS04880"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CDO52_04870"
                     /product="IS5 family transposase"
                     /protein_id="WP_394340787.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MAILVSVSGRHELTDAEWALLAPLMPDNPPKGGQWADHRRVINAV
                     LFRTRTGIPWRDLPERYGPWETAAGRHRRWCLDGTWQRIADRLRIDAATGEDLVVGIDS
                     TSVRAHSHAAGAAKKGSGTGRSGRLGSTGTFPGGLTTKIHLIADQRRRPLVTATSPGQR
                     GDAPMFEPLMVALHLPRSVGRPRTRPDRLLADKAYSSAAIRSHLSRRGIKATIAQPADQ
                     RANRRRRGSAGGRPPAFDRGAYRGRNTVERAINLLKQNRAVATRYDKRAAIYDGTVQLA
                     SIRIWLRDLTRSKNTA"
     misc_feature    3403..3412
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            3522..3890
                     /locus_tag="CDO52_RS04885"
                     /old_locus_tag="CDO52_04875"
     CDS             3522..3890
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620555.1"
                     /locus_tag="CDO52_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04875"
                     /product="DUF6507 family protein"
                     /protein_id="WP_017620329.1"
                     /transl_table=11
                     /translation="MSGWDINPEGVGGVLQTVSGHLGDEEGTEGLTSDIKSFGNHIETA
                     AVKADSGPIGTALHGFFDKYSEEMRAMASKTASAVNGCGNAVSAYMDGNLEMAAEAQSN
                     AGTVEDPGLNRPKGAELQ"
     gene            3973..6438
                     /locus_tag="CDO52_RS27190"
     CDS             3973..6438
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037249.5"
                     /locus_tag="CDO52_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_152471772.1"
                     /transl_table=11
                     /translation="MSDSEMVNFKKVFVPDVDPDELETAAAGLKKDGSNIADAGNDIKS
                     AWQGLSEVYSAPESEQLLSAINPVATKGDDIDDATSTVADALLTFAEKARKLKKRLENL
                     RHDALLFFAAHSSDEDWADDEDLREENNKRKTDIDAAFLEYQAAERECANKITPLYDGP
                     EFVADNGEIIPAGKKAYGVEEIPEEAAMPWGSTVEPDSNFFLDLGTALWEFTPLAMGWD
                     AGVNAAYASGFYTDEGWGVESAEEWWGNVMAHHDETNKNMRALVGQVKVQGTGPGLWGE
                     WEFREGVADEAWSGVWDGMTGLSQWDDRPGYTIGTSVMTTISFIGGAAGLARGGTRALA
                     TAGRAISKWKPGLGSFNPNGGVPTLGRGKFPNPSLDFGGEHGASPGFGTHESSGTDHGP
                     SANSGQGSPSEGYQGSSPDSSGDGLPGRQQEGPGQSGHTPDSNGAHSSSAGNDHGTQPD
                     SSPEPRVNQESQTQHGQAPSTPAQRNGSTTPERHDEAGVGSREGASDSSAPARDNHANT
                     DRTTTEVQRDISRLEELTKKHDGNIDAALDELARERQPELVGAGARHGDMGPTASAGDG
                     PGSPNSGTGHGGEHLYTPQESVSHGGSIRPDSGGSTGGGHGFGQDSSGTPGNGSSGVGP
                     ADDHGIGSGGSGSTPDGGVGSVKPSKPILAGIGESVPHEGRLPRPEDLPPGTRKHPTVE
                     ELRDRTGEGWEYYDSKEREIAEFLQEHGIEVRSVDVARSDGVKSPDSVIEGTNSTLEFK
                     TVETSSKNALIQNIRKGRDQSSRLAIDLRAGGTTQDAAMAGLKDALRRYGGDLEEIVLI
                     GDGYVITWP"
     misc_feature    4022..4035
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.64"
                     /tool="antismash"
     gene            6451..6810
                     /locus_tag="CDO52_RS27195"
     CDS             6451..6810
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_152471771.1"
                     /transl_table=11
                     /translation="MAHSETIMVSAQYDEVVSVMSSLSSSVSSGRSGDVAEVRIDDLVL
                     DVESFDIYEGFATAIDVYGKSREGAISNARHIFDLLSKVTSWRIALGFDEKDNPIVERP
                     EQAAGGERGQDGGRA"
     misc_feature    6480..6494
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            6870..7328
                     /locus_tag="CDO52_RS28545"
     CDS             6870..7328
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS28545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_232524386.1"
                     /transl_table=11
                     /translation="METEIKRGHLGPVEQHQILTNIGREIVSGVPDNWEGLEYSAKSII
                     SGTADLLLATYDGGQTESIDMPDSILGMLRELRAGMYQEAKGTCSMKYTIVRPGNFNTE
                     FNYDNDPGFTFEPTPEEFVRDLQCFPRDDEYIPAWLREKIRAAEEGGE"
     misc_feature    6907..6920
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            complement(7583..7987)
                     /locus_tag="CDO52_RS04895"
                     /old_locus_tag="CDO52_04885"
     CDS             complement(7583..7987)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_04885"
                     /product="hypothetical protein"
                     /protein_id="WP_033301270.1"
                     /transl_table=11
                     /translation="MFILGALELAAGLFVSFGSFIVGHTAAPGSSNATLSTVLGIVGAL
                     AVAIGISSFVLGLLAVKRSQAVMWTIACFHSALAALGIVAFIGSAVSDGQNGNNIGAVA
                     TLVMSVLIVSFTLTKDARMHYRSGKSSSGN"
     gene            8596..8967
                     /locus_tag="CDO52_RS04900"
                     /old_locus_tag="CDO52_04890"
     CDS             8596..8967
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620326.1"
                     /locus_tag="CDO52_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04890"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_017620326.1"
                     /transl_table=11
                     /translation="MAKFGELEAAIMRSVWAGSEPMRVRDVVDDLQRERDIAFNTVQTV
                     MDILFRKGWLKRAKEGRAYRYWAAASQEDYATKLVEEALESAPDQAAVLSRLITQLPED
                     ELSGLRAALNDAKRREGMT"
     gene            8964..10034
                     /locus_tag="CDO52_RS04905"
                     /old_locus_tag="CDO52_04895"
     CDS             8964..10034
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620325.1"
                     /locus_tag="CDO52_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04895"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_017620325.1"
                     /transl_table=11
                     /translation="MIIALLLLGYGLLLAVFGPLAVRRARWVERAPRLGIAAWQTLSIA
                     FLASLVLGGLALSVPDLRLDTGLAQLLDACLAALRAQYATPDGIAIGLSGLGLALLLGL
                     RCAWSIARTLTRAVADRRRHVDALRILARQDRATGAMVLEYALPAAYCLPGNRGQIVLT
                     SGALDALSPEQLQAVLAHEHAHLRGRHDLVAAAATGMADAFPGLPLLRVIRDETLRLLE
                     LAADDAAARTTHRLVAAEALLNVADHHRPAGAFAVGGPGTGDRVKRLIAGVAPFGRSRA
                     LLVGTLAAMPIAVPLTLFAGPAAALVDSTCCPTDIPTMRHPVEVCASMPNMQDCLTLRP
                     GYSDAPYGTGPSWTNP"
     gene            complement(10001..10756)
                     /locus_tag="CDO52_RS04910"
                     /old_locus_tag="CDO52_04900"
     CDS             complement(10001..10756)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620324.1"
                     /locus_tag="CDO52_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04900"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_017620324.1"
                     /sec_met_domain="CDPS (E-value: 1.1e-60, bitscore: 203.3,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTPETPGVIAPPRSGDAAPPARDTAEEGPRVRPLSPSCASAFD
                     KGEHACLGISPFNGYFTTERITVLARWALDRFSTVHLYMPDGPSALTLEASGYPRRRAS
                     AKARRQANYLRNKMIRALDAVGAAEPQGMILDSGTLAGNRRYERLLGEAHALFDADAAF
                     QEACLDAGRWILADRVESAELTTERMGIAARYLLAELPFFTHTPHIVGTASSVFCYHRP
                     PDFVERLFQRRLPWGPQDGQGFVQLGPVP"
     gene            complement(10919..11668)
                     /locus_tag="CDO52_RS04915"
                     /old_locus_tag="CDO52_04905"
     CDS             complement(10919..11668)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620323.1"
                     /locus_tag="CDO52_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04905"
                     /product="hypothetical protein"
                     /protein_id="WP_017620323.1"
                     /transl_table=11
                     /translation="MSSRGHTNSSSSSSTSTGASKQRRKRQRAEKIALMQAEQARRERR
                     KRVLVFGSVAAMGILVIGIAGWGITQLPDSEKTTPLPELVSGEGTNLPPWPLPEDPVAL
                     AEKASLRVAPMEGTAEHFHTHLDVIVDGEPVTVPANIGIHPAGTAMSELHTHDERGVIH
                     IEAPTDDKRYTLGQLFAEWDVKLDEDTLGGLEADETNTLRAYVDGEPFDGDPARIELKP
                     RGQIALIYGPKDADVEVPDDFDFKPGE"
     gene            11808..12638
                     /locus_tag="CDO52_RS04920"
                     /old_locus_tag="CDO52_04910"
     CDS             11808..12638
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621805.1"
                     /locus_tag="CDO52_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04910"
                     /product="cupredoxin domain-containing protein"
                     /protein_id="WP_232524387.1"
                     /transl_table=11
                     /translation="MPLPLMPPRARLGLAGAVTVLVLAGCAADSDTDAPNPTASASSPA
                     PSSENDSSSGHGHKHEMREAEGAPAPSVSMQVSEDPVSGWNVRLKVKEFAFTPERAGGK
                     PRDAEGHAHLYVDDEKVARVYGSWYHLPASAVPEGEHTLSVRLSANDHSTWGIDGKPIA
                     DSATITGEGSDGSSASSDTDNDSEGDADVTAEISVSDGSVSPEPGRLEVEKGQRVRIEV
                     TADTADTVHLHGYDIGESVGPKKPAVLTFTADQAGVFELETHDSGLLLTQVAVE"
     gene            12635..13972
                     /locus_tag="CDO52_RS04925"
                     /old_locus_tag="CDO52_04915"
     CDS             12635..13972
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620321.1"
                     /locus_tag="CDO52_RS04925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04915"
                     /product="hypothetical protein"
                     /protein_id="WP_017620321.1"
                     /transl_table=11
                     /translation="MNPNLGLAVDLAHGIGGRDDLPLPLSHALTGAAVAVVVSFVAAGL
                     LWRTPRRPGDTAGRPLPPRLQSALDGPVIRWGLRLLGLAAAVFAAVAAVLGRNDALNPV
                     PGFVYVFLWVGLVPASLLFGPVWRLLNPLRTVHLLLARLTRTPPDRGLWRCPDWLGYWP
                     AAAGLLAFTWLELVWPHSTDLASLRLWFAAYAAVQLLGALAFGNRWFDRADAFEVYSTL
                     IGRLAPLGRRGDGRLVLRGPFSGLDGMKPVAGITATVSVMLGSTAFDSLASAPWWIGYT
                     QTVPLPGLLTGTLGLVGMALLAAALLSGGALLAGVIGGRSRAGLPSAFAPSVIPVATGY
                     LIAHYFSLFLFEGQRTLILASDPLGTGANLFGTAERGVEFSVVSPETIALVQVGAVVAG
                     HVVGVVAAHDRAIRLFAARRAVLTQLPLLVLMVAYTVGGLALLFAT"
     gene            14087..14704
                     /locus_tag="CDO52_RS04930"
                     /old_locus_tag="CDO52_04920"
     CDS             14087..14704
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620320.1"
                     /locus_tag="CDO52_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04920"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_017620320.1"
                     /transl_table=11
                     /translation="MGRSTRLVITAAAAIAALGVTTAVGAVLLSEGRGTERVPSPEATS
                     APTGVTRYALAERPDAPPLAGPRLDGGRMDLDAPDGQGQVSVINVWGSWCPPCREEAPD
                     LQRVWEGVESDGVRFMGVNTRDTEAGAEAFVEEFGVTYPSIVDPDGDALLAWREIIPVQ
                     AIPSTVVVDREGRVAARVIGPVDAATLRGLVNDIVNEGKPAQ"
     gene            14854..14991
                     /locus_tag="CDO52_RS28030"
     CDS             14854..14991
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS28030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_017620319.1"
                     /transl_table=11
                     /translation="MTVIDGESNNGYHGNYMEPPYQMPALTFTDTSGRDFDLARTPRSP
                     "
     gene            14997..15377
                     /locus_tag="CDO52_RS28035"
     CDS             14997..15377
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014667.5"
                     /locus_tag="CDO52_RS28035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SCO family protein"
                     /protein_id="WP_017620318.1"
                     /transl_table=11
                     /translation="MFFGYTNCPDVCPTVLADAAAAIRRMPEERKDDVELVFVTTDPDR
                     FDPSFVGLTGDMDTIEQAADDLIVEIEPKEEQADGGYTTDHGSHVIGFDADDQGWLLWT
                     PGTPVGDLREDYTRFLTEFPAD"
     gene            complement(15355..15684)
                     /locus_tag="CDO52_RS04940"
                     /old_locus_tag="CDO52_04930"
     CDS             complement(15355..15684)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CDO52_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CDO52_04930"
                     /product="SHOCT domain-containing protein"
                     /protein_id="WP_094932222.1"
                     /transl_table=11
                     /translation="MMGCHGMTGAETGWAEAVATTLAPLLTVAVVIAVAILVLRNTALT
                     TLATPTVRHRQSPPPVVDGPIEMLKERYARGEVDHGEFERRLDVLMRNREEWPRQTAPS
                     PRGTR"
     gene            complement(15888..17159)
                     /locus_tag="CDO52_RS04945"
                     /old_locus_tag="CDO52_04935"
     CDS             complement(15888..17159)
                     /EC_number="3.2.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017598918.1"
                     /locus_tag="CDO52_RS04945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04935"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_232524388.1"
                     /transl_table=11
                     /translation="MRESTAATGYTAVSEAAAILSRMGSSTMSTMPRLLPDPDPDRLLG
                     CLLGGAIGDALGAPIEGIPIAQIREKYGPDGLTEYSPERVGVGAITDDTQMMAFTAQAL
                     IQASVRQRAKGIGGAAIGMLQESYLVWLRGQGENIPEQGLGGGYGWLGQDNVMMSRRGP
                     GKTCLSALHKAAERQKPGWPLGTVDEPINDSKGCGGVMRAAPCGFGVISVEVAFDMGCR
                     AAALTHGHPSGYLSAGVLAATVWSLVRGAQLDSALELARAELMERQGHEETSKALDAAI
                     TLARQGSPRPEQLERLGSGWTGEEALAMGVYAALSAELSMVNDPPNPYSSRRGPAEIGR
                     RGLRLAVNHSGDSDSTGAICGNLLGARYGSTVFPGHWQANLEVRRTIIQLAADCALEFG
                     PDSPTEPDGYGAPSFQWLQRSPKA"
     gene            complement(17253..17951)
                     /locus_tag="CDO52_RS04950"
                     /old_locus_tag="CDO52_04940"
     CDS             complement(17253..17951)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620315.1"
                     /locus_tag="CDO52_RS04950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04940"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_017620315.1"
                     /transl_table=11
                     /translation="MSIELTDIVLTYPDGDSTVTALNRVSLEVGPGELHAVLGPSGSGK
                     SSLLAVASTLIRPDSGSVRIDGTEATSLSPAQLSRLRMSRIGIVFQQPNLISSLTAVDQ
                     LLVTEHMRGRSARKRREAAEHLLAIVGLDGKQHRRAAQLSGGERQRVNIARALTGEPQV
                     LLVDEPTAALDHDRGAQIMDLLTEITREYNVATVVVTHDTEYLDRADTVSRMRDGRLTT
                     DSVTVGGGAR"
     gene            complement(17948..19042)
                     /locus_tag="CDO52_RS04955"
                     /old_locus_tag="CDO52_04945"
     CDS             complement(17948..19042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014912527.1"
                     /locus_tag="CDO52_RS04955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04945"
                     /product="ABC transporter permease"
                     /protein_id="WP_094932223.1"
                     /transl_table=11
                     /translation="MFVAIRDIRFAKGRFALMGSVVALITLLVVLLSGLTAGLAAESVS
                     AVDRLPADRIAFGAAGDSEPKESFADSSVTADQVDTWAGAEGVAWAEPLGITQTRVEAP
                     DGSTTAATIFAAEPGEDLAPDGTADDSLVVGRSLADEKGLEVGDVLTLGGTDLTITRIA
                     RDDSYSHTPVVWTSLDTWRSFAPSGTANGSPAGTVIAIGMGADHAPADTAAIDTDAETV
                     SATRSDSLSAIGAFSSENGSLLMIQGFLYAISALVVGAFLTVWTIQRSGDIAILKALGG
                     STGYLLRDALAQALLVLLAGAGVGGLAGFGVGVLAERVVPFSLTVATTVLPVAAMVVLG
                     MLGAVLSVRRITSVDPLTALGGVR"
     misc_feature    complement(19141..19155)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            19217..20482
                     /locus_tag="CDO52_RS04960"
                     /old_locus_tag="CDO52_04950"
     CDS             19217..20482
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620312.1"
                     /locus_tag="CDO52_RS04960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CDO52_04950"
                     /product="sensor histidine kinase"
                     /protein_id="WP_017620312.1"
                     /transl_table=11
                     /translation="MDTAHQAPFSSFSTGTVTVLAVMRACLHAAFFVLLGVAALRLFTV
                     REAGHWSWAALVGAALLAALYTSGPLVMRRLPPGRLPARSAARVWLALVTALWAILLLI
                     SPDFSWLAFPLFFLHLHLLRRYHAVVAVAVITGAVIAAQALHARDISVAMVLGPTLGAA
                     FAVVIALGYSALYAESEQRRRLIDDLRRTQDELADSQHRAGALAERERLAREIHDTLAQ
                     GLSSIVLLLRSAEGAVRADPDAALARIAEARESASENLDEARGFVRGLAPPALAGGGSL
                     PDALRRLCSRVAAASGIDCQCRVEGEPVPLPADYEVALLRAAQASLANVAAHSGASTAV
                     VTLAYLGTEVTLDVFDNGRGFDPTAVPQSRSDGTGYGMRALRDRITALGGRLHIESAPG
                     EGTAVAVALPFVAENNNAKEEE"
ORIGIN
        1 cgaatactcg gcagctgcgg cggctgggcg aatccgtcgg cggtgacgcg gaagcgtacg
       61 ccctcgcccc cggtgagaga cgcctgcgcc tggaaggggt aggcgacctg gtagcggtgg
      121 taggcgtctg cgtcattccg gacggttccg gggaggccac gctcggcgaa gggcgtgccg
      181 tcggggaaga acagggagcc gctctcctgg ccgtaggcgt ccaccacctg gcccggctca
      241 agggtcacgc gactcggggt gccagctcgc ccatcgatct tctcccggac ggacgtggcg
      301 agttcggagg tctgctcgga ggccttctgc tcctcctcgt cgctgagcac gcgggggtcg
      361 gcggcgcccg tcaccagctc caggtacagc cagcgtgcgg cctcgtcctc tgtgcggaac
      421 tcggcgccgg tgcgtccctg cgcgaactcg acgatgccga tggagtagcc gtcggcgcct
      481 tccttggtca gcaggtagta gctggaagca gtggccgggt cggggcggtc gtcgccgggg
      541 aggacgtaga ggtccggggg cacgtgggcc cggtcgagct ccttccgcag catcgggaag
      601 gtgacctcgg caccgatcca gtcggcgggg aggggcgcgg tcgcggcgtt gggaccggcc
      661 gcctgctgct cctgctgttc cttctggctt ttgaggtggt tctgcaggaa cgaccagccg
      721 accgtgcccg cgcagatgac agcggatacg accaggctgg caatgatctt tccgatgttc
      781 tcgtcgaggc gtcggcgggt gcgctggggg ccgaagaaca cggcttcgcg gagtcgcttg
      841 cggcgcacgg cggtcgactc cagcagctga ctgtcgtagt cgcgtgccat cgcagactcc
      901 cttcgaggcc tcggcggtgg tttgtcccta ccggatcgcg atcacgcgca cggcacgcgg
      961 cgggacgcgg agtacggagg tgatggacca cggaacggga aacgcacgga acgggagggg
     1021 cgtccgtcgc gtggacggac acccctcccg tggacgcatg tggtgcctct cgatacttcc
     1081 agacctcccg gaccaccgca cactcagggg tgggctgacc agggaggagg cgtcagacgt
     1141 cagatgccct ggaccgctgc gctggcacgg ccgagcgtgg actgggcggt gccgtcgttg
     1201 gtctccaggg tctcgcggac gagccggatg atgtcgcgga cctcattgcc cgcgttgtgc
     1261 cacttcagtt ccttctcgct gtactcgtcg gagacgccag tggcctcgaa gtcggccatc
     1321 gccttgctca cgtcgacgtc gtgctcaccg atgagggatt ccagccgcga catgacggcg
     1381 tggatgttgg tctgggactc ctgcgaggcg ccgaggtcgt agctgttgcg tccgttgccg
     1441 ctcattgagg gaactcaact ccttggaaca cggtggggat cgttcgggga gggacccggg
     1501 gtcacgtcgg gcgcggtcag gccgtccgga acttcgcggc gtcgaagttg gccgctgaca
     1561 tgttgcgatt ggcgtcgtcg gccatgttct ggttaccgct cgagaaggcc gactgcatgc
     1621 cgtactgccc ctcgttgacg cgaccgaggc cggagttgag gtcggcagtg atcccgtcgg
     1681 cacgggcctt gaacgagtcg aaggcggcct tccccgcgcc gttgaacttc ccggacagcg
     1741 gctcggccgc ctggatcagc tgcgtgatca ggttgctcag ttcgtcggtc gcccccgagg
     1801 tactgcgggc cagggtcgtc agggtctggt cgccgaagtc ccaacgtgac atctcttcac
     1861 ccgttcctcg tcgtccatcg gttgcggggg tcggggccgc ccgcgcgttc gctgagccac
     1921 cactggcgga cagggggctc tcgggggtcg gacgcgcaca gcggaccgct ggtttcctgt
     1981 ggtgggcgtg accgtaatta atacagctgc tctcaccgtg cgtcgtcaag cataggcata
     2041 atgccgacaa acggaactcg gcggatgcgg gtgagcacgc tgcgcatgtg gggagatcga
     2101 tgaagtttca gcaggtagac ccgggcgagt gggactccgc cgaaccttct gccgcggccg
     2161 aggggcgtcc ggcaccggat gtgtcctcag gcacacccga ctccgctgaa cagatggatc
     2221 cagcagcccg gctcagcgca gcggcatccc tattgacctg cgatatcggc cgcgatgctg
     2281 ccagcgcgag cgaatcgatc gcggcgttga tgcagcgaat cgccgaccgc aaccgaaagt
     2341 cgaccgattt cggccacccc gccccaccac ccccacccac gaccttccgc gccgaccgct
     2401 tcgcagggtc cccgccaccg gaaggtgcct ccgactaggg cctgtttttt gaatcggcgg
     2461 gtggagtggg gctcgcgctg gcaatcttgg tgagcgtgtc cggccgtcat gaactcaccg
     2521 atgccgagtg ggccctgctc gccccgctca tgcccgacaa cccgcccaaa ggcggccaat
     2581 gggccgacca ccgccgcgtc atcaacgccg tgctgttccg aacccgcacc gggatcccct
     2641 ggcgtgacct gcccgaacgc tacggcccct gggagaccgc ggccgggcgc caccgccgct
     2701 ggtgcctgga cggcacctgg caaaggatcg ccgaccggct gcgcatcgac gccgccaccg
     2761 gagaagacct ggtggtcggc atcgactcca ccagcgtgcg cgcccactcc cacgccgccg
     2821 gagccgcgaa aaagggaagc ggtacgggac gaagcggacg gctcggaagc actgggacgt
     2881 tcccgggcgg gctgaccacc aagatccacc tgatcgccga ccagcgcagg cggccgctgg
     2941 tgaccgcgac cagccccggc cagcgcggtg acgcgcccat gttcgagccg ctgatggtcg
     3001 ccctgcacct gccccgctcg gtcgggcgcc cccggaccag gcccgaccgg ctgctcgcgg
     3061 acaaggccta ctcctcagcg gcgatccgct cccacctgag caggcgcggt atcaaggcga
     3121 ccattgccca gcccgccgac cagcgggcca atcgcaggcg caggggatcg gcgggcggtc
     3181 ggccccggct ttcgaccggg gtgcctaccg cggccgcaac actgtagaac gggcgatcaa
     3241 cctgctcaag cagaaccggg ccgtggccac caggtacgac aagcgcgccg cgatctacga
     3301 cgggaccgtc cagctcgcct cgatacggat ctggctacgc gacctcaccc gttcgaaaaa
     3361 cactgcctag acaggaccac cgctcaacac cgccctatgg ccgaaggcgg ccacgatgcc
     3421 gcatgcatcg gattggaact gtcgctaccg ttcggtagtc atatctgggc gcgcagttac
     3481 agcaatatcg gcctcacgga gccgcacggg aggacaagta cgtgagcggg tgggacatca
     3541 accccgaggg tgtcggcggc gttctgcaga cggtctccgg tcacctgggc gacgaggagg
     3601 ggaccgaagg tctgacctcc gacatcaagt cgttcggcaa tcacatcgaa acggcggccg
     3661 tcaaggcgga cagcggaccg atcggaaccg cgttgcatgg gttcttcgac aagtactcgg
     3721 aagagatgcg ggccatggcg tccaagaccg ccagcgcagt caacgggtgc ggcaacgcgg
     3781 tgagcgccta catggacggg aacctcgaaa tggccgcgga agcccagagc aatgccggaa
     3841 ccgtcgagga cccgggcctg aaccgcccga agggcgccga gctgcaataa ccccccattg
     3901 gtaggcggca cggccgctcc tccacgatcc ccttcccccg cacatgcagc gcaacaggat
     3961 ggcgaggcgt cgttgagcga ctccgagatg gtcaacttca agaaggtctt tgttcccgac
     4021 gttgaccccg atgaactgga aacggccgcc gccggactca agaaggacgg cagcaacatc
     4081 gccgacgccg gcaacgacat caagtccgcc tggcagggcc tgagcgaggt ctattccgcc
     4141 cccgaatccg agcagctgct gtcggcgatc aacccggtgg ccaccaaggg cgacgacatt
     4201 gatgacgcca cgagcacggt ggcagacgcg ctgctcacct tcgccgagaa ggcccgcaag
     4261 ctcaagaagc gcttggaaaa cctcaggcac gatgcgcttc tgttctttgc agctcacagc
     4321 agtgacgagg actgggccga cgacgaggat ctgcgcgagg agaacaacaa gcgcaagacc
     4381 gacatcgatg ccgctttcct cgaataccag gcggctgagc gggagtgcgc caacaagatc
     4441 actccgctgt acgacggccc tgagttcgtc gcggacaacg gcgagatcat ccccgcaggc
     4501 aagaaggcct acggggttga agagatcccc gaagaggcgg cgatgccctg gggctccacc
     4561 gtggagccgg attccaactt tttccttgac ctaggtaccg cactttggga attcacaccg
     4621 ctggctatgg gctgggacgc tggggttaac gcagcgtacg cgtcaggctt ctataccgac
     4681 gagggctggg gcgtggagtc cgcagaggag tggtggggaa acgtgatggc ccaccatgac
     4741 gagacgaaca agaatatgcg ggcattggtg ggccaggtca aggttcaagg cactggtccc
     4801 ggactttggg gcgaatggga gttcagagag ggcgtagccg acgaagcgtg gagcggcgtg
     4861 tgggacggta tgactggctt gagccagtgg gatgatcgtc cgggatacac catcgggacc
     4921 tccgttatga cgacgatcag ctttatcggt ggtgctgctg gattggcccg tgggggaacc
     4981 cgggcgttgg ccacggctgg tcgggctatc agcaagtgga aaccgggcct tggctccttc
     5041 aaccccaatg gcggtgtgcc caccctggga agaggaaagt tcccgaaccc atcgttggac
     5101 ttcggcggcg agcacggcgc ttcgccaggc tttggcaccc acgagtcctc gggaactgat
     5161 cacggtcctt cggccaacag tggtcaggga tctcccagcg agggttatca gggatccagc
     5221 cctgattcct cgggagacgg gctgcctggc cgtcagcagg aaggaccggg gcagtcggga
     5281 cacacccccg acagcaatgg cgcccacagc tcctcagccg gtaacgacca cgggacacag
     5341 cccgactcct cgcccgaacc gcgtgtgaac caggagtctc agacccagca cggccaggct
     5401 ccctccactc ccgcccagag aaacggctcc acgacaccgg agcgccacga cgaggccgga
     5461 gtcggttccc gcgaaggagc ctcggacagc tctgccccgg ctcgtgacaa ccacgccaac
     5521 accgaccgaa ccactaccga agtccagcgc gacatctcgc ggctcgagga gctgacgaag
     5581 aagcacgatg gcaacatcga cgcagcccta gacgaactcg cgcgcgaacg ccaacccgaa
     5641 ctcgtcggtg caggggctcg acatggagac atgggaccca ccgcctccgc aggagacggt
     5701 ccgggatccc cgaactcggg cacaggacac ggcggggaac acttgtacac gccacaggag
     5761 tcggtctcac atggaggcag cattcgccca gactccggcg gttcgacagg aggagggcat
     5821 ggcttcggcc aggactcctc ggggactcca ggaaacggta gtagcggcgt tgggccagct
     5881 gatgaccacg ggattggcag tggtggcagc ggatccacgc cagatggcgg agtgggtagc
     5941 gtcaagccgt cgaaacccat actcgcgggc ataggcgaat ccgttccaca cgaaggccgt
     6001 ctgcctcgcc cagaagacct cccgcctgga acacgaaagc atccgacagt ggaagaattg
     6061 cgtgatcgga ctggcgaggg gtgggaatac tacgatagta aagaacgtga gatcgccgag
     6121 ttcctccagg aacatgggat cgaggtgcgc tctgtagatg tcgcccgctc ggatggagtg
     6181 aagtcaccag actccgttat tgagggaacc aactcaacgc tcgaatttaa gactgttgag
     6241 acatcttcga aaaacgcatt gattcagaac attcgaaagg gtcgtgacca gtcaagccga
     6301 ctcgccatcg atcttcgggc tggggggacg acgcaggatg cggcgatggc aggactcaag
     6361 gacgctcttc gcagatatgg tggggacctc gaggagatcg ttctcattgg tgacggttac
     6421 gtaatcacct ggccctaaag ggagaagtaa atggcacatt cggaaacaat tatggtttct
     6481 gctcaatatg acgaagttgt ctctgtcatg tcctcccttt cttcgtcggt ctcgtcgggc
     6541 aggagtggcg acgtcgcgga ggttcgcatt gatgacctcg tgttggatgt tgagtcgttc
     6601 gatatttatg agggattcgc cacagcgata gatgtctacg gaaagtcgag ggagggtgca
     6661 atctcgaatg cacggcatat ttttgacctc ctttcgaaag taacgagctg gagaatcgct
     6721 ctcggttttg acgagaagga taatcccatt gttgagcggc ccgagcaggc ggctgggggt
     6781 gaaagggggc aggatggtgg acgagcttga ggacgccctg caggatggag tacttgactg
     6841 tgcggaagtg aagggaaagc caagcggaga tggagactga aatcaagaga gggcacttgg
     6901 gtcctgttga gcaacatcaa attcttacga atatcgggag ggaaatcgtt tcgggtgtgc
     6961 ctgataactg ggaaggactt gaatacagcg ccaagtcgat cattagtggc acggccgatc
     7021 tccttttggc cacctatgac ggcggccaaa ctgagtcaat agacatgccc gacagtatct
     7081 tgggaatgtt gagggaactg cgcgctggca tgtaccaaga agccaagggt acgtgttcaa
     7141 tgaaatacac catcgtgcgt cctggtaact tcaataccga gttcaactat gataatgacc
     7201 cgggattcac gtttgagccg acgccagagg aattcgtgcg tgatcttcaa tgcttccctc
     7261 gtgatgatga atacattccc gcctggctgc gcgagaaaat tcgggccgct gaagagggcg
     7321 gtgaataaga agcgtggccg gtgatttcac tggggtctgg aggatttctg cctggcctat
     7381 gacgctgaac ttcacggacc cgaactcagt atcgaggtcg agtcgccgtg tattgccggt
     7441 atcctgctga agcgcccctg ggtcggcgag tttgatacct gggtcgaggt gccgcgagga
     7501 tgcttagtgc gtgctcccac caccgggaaa tgaggggatc tcgctgagtt ctcggtggcg
     7561 ggggcggtcg agtggggctt cgttagttcc cggagctgct ttttcctgac cggtagtgca
     7621 tccgcgcgtc cttggtcagc gtgaatgaga cgatgaggac gctcatgacg agggttgcga
     7681 cggcgccgat gttgtttccg ttctgcccat cggatacagc ggaaccgata aatgcgacga
     7741 tgcccagcgc ggcaagtgct gagtggaagc aggcgatggt ccacatgacc gcttgcgagc
     7801 gcttgaccgc gaggaggccg aggacgaacg aggaaatccc gatcgccacg gccaaggcac
     7861 cgacgattcc gagcacagtc gatagggtcg cattgcttga cccgggagcg gcggtatggc
     7921 cgacgatgaa gctgccgaag ctgacgaaaa ggcccgcggc gagctcaaga gctccgagga
     7981 tgaacatgag gatgcgggca ttggtgactg actggggtgg cctgggcttg gctggctgtt
     8041 gccagtaggg agtgccgtat ggcgccgctg gatagccggg gtagccggtc gggtagggct
     8101 gtccgggctg gggagcctgc gggtgctgag ggaacggttg ggcgtactgg ccagaggcaa
     8161 gctgcgcttg ttgccccgcg ttgggtggtg cgtacggccc cgggttgggc tgcgcgtgcg
     8221 gtccgccggg tgggggagcg gcggggtcag gatgttcagg atgcacggaa cgtctcctgg
     8281 tggtcggttt gggtaaccgg ggcaatgtac atgttttggg cgcgcccagt ggacgcctgt
     8341 agtgcggcgg aatgggtttt gcgaagtgtc gtccagctgc cacctgggcg gggcttctgc
     8401 ggagtgaatg ccgtgtggcc gcgtgtggac agttcggggc gaaggtgggc tcggctgggc
     8461 gtggcgcgcg tccgtggctg gatcgactcg gaacctcgag aatggcttcc agaaatcacc
     8521 taagctgatt gagtatgcgg cgggtgtgct gcgatctcgc cgaggtgtga ggaagtagta
     8581 ggaggcagga ggccgatggc gaagttcggg gagcttgagg cagcgatcat gagatcggtg
     8641 tgggcgggca gtgaaccgat gcgcgtgcgg gatgtcgttg atgacctgca gcgtgaacgc
     8701 gacatcgcct tcaacaccgt gcagaccgtc atggacatcc tcttccgcaa gggctggctg
     8761 aagcgggcca aggaagggcg ggcctaccgg tactgggcgg ccgcgtctca ggaggactac
     8821 gccaccaagc ttgttgagga ggctctcgag tccgctcccg accaggccgc cgtcctctcc
     8881 cgactgatca cccagttgcc cgaagacgag ctctccggac tccgtgccgc cctgaatgac
     8941 gccaaacgcc gcgagggtat gacgtgatca tcgcgctgct gctcctgggg tacggcctcc
     9001 tcctcgcggt cttcggaccc ctggctgtgc ggcgggcgcg ctgggtcgag cgggctccgc
     9061 ggctcggcat cgccgcatgg cagacgctca gcatcgcctt cctcgcttct ctcgtgctcg
     9121 gcgggctggc actcagcgtg cccgatctgc ggctcgacac cggcctcgct cagctgctcg
     9181 acgcctgcct ggccgcgctc cgtgcgcagt acgccacgcc tgacggcatc gccatcggcc
     9241 tcagtgggct cgggctggcg cttctgctgg ggctgcgctg cgcgtggtcc atcgcccgga
     9301 ccctcacgcg cgccgttgcc gaccgccgcc gccacgttga cgccctccgc atcctggccc
     9361 gtcaggatcg agccaccggc gccatggtcc tcgaatacgc gctgcccgcc gcctactgcc
     9421 tccccgggaa ccgcggccaa atcgtcctga ccagcggcgc cctggacgcg ctctcacccg
     9481 aacagctcca ggcagtgctc gcgcacgaac acgcccacct gcgcggcagg cacgacctcg
     9541 tggccgcggc cgccaccggc atggccgacg cctttcccgg cctgccgctg ctccgcgtga
     9601 tcagggacga gacgctgcgc ctacttgagc tggccgccga cgacgccgca gcccgcacta
     9661 cccaccgcct cgtggcagcc gaggccctgc tcaacgtcgc cgaccaccac cgcccggccg
     9721 gcgccttcgc cgtcggaggg ccgggcaccg gcgaccgcgt caagcgcctc atcgccggtg
     9781 tggccccctt cggccggagt cgggcgctgc tggtgggcac cctcgcggcc atgccgatcg
     9841 cggtgccgct gacgctcttc gccggacccg ccgctgccct ggtcgactcc acctgctgtc
     9901 ctaccgacat cccgaccatg cgccaccccg tcgaggtgtg tgcgtccatg ccgaacatgc
     9961 aggactgcct cacgctccgc cccggctact ccgacgctcc ctacggcact gggccgagct
    10021 ggacgaatcc ctgaccgtcc tgtggccccc agggaagacg gcgttgaaaa aggcgttcca
    10081 cgaaatccgg tggccggtgg tagcagaaca ccgatgacgc cgttcccacg atgtggggcg
    10141 tgtgcgtgaa gaacggaagt tcggccagca gatagcgggc cgcgatgccc atgcgctccg
    10201 tggtcagctc ggccgactcg acccgatccg cgagtatcca ccgaccggcg tccagacaag
    10261 cttcctggaa tgcggcatcg gcgtcgaaga gtgcgtgtgc ctcgcccaga agccgctcgt
    10321 agcgacggtt gcccgcgaga gtgccggagt cgaggatcat cccttgcggc tcggccgcgc
    10381 ccaccgcgtc aagcgctcgg atcatcttgt tgcgcaggta gttcgcctgt cgtcgcgcct
    10441 tggccgaggc acgtcgccgc gggtagcccg acgcttcgag cgtcaacgcc gacggcccat
    10501 cgggcatgta gaggtggact gtggaaaagc ggtccagcgc ccaccgggcc agcacggtga
    10561 tccgctcggt ggtgaagtac ccgttgaacg ggctgatccc caggcaggcg tgctcaccct
    10621 tgtcgaacgc cgatgcgcag gagggggaga gcggccgaac tctcggcccc tcctcggcgg
    10681 tgtcccgcgc gggcggtgcg gcatcgcctg acctgggtgg agcgatcacg ccgggcgttt
    10741 cgggcgtacc ggacacgggg gttcctcgct ctcgtggtcg tgtcgtccct gtctgggtgc
    10801 gcacgggggg aggggcgctc ccatccggtg accagtcttg cctaacgtgc ttaggttttg
    10861 tgggatcggg gcgtgggtgt gtcccccgat gtgcgacggg gcggcgggcg ggtgcctctt
    10921 attccccggg cttgaagtcg aagtcgtccg ggacctcgac atcggcgtcc ttcggcccgt
    10981 agatcagggc gatctggcca cgcggcttca gctcgatccg tgccggatcg ccgtcgaagg
    11041 gctccccgtc gacataagcg cgcagcgtgt tggtctcgtc cgcctccagt ccgccgagcg
    11101 tgtcctcgtc cagcttgacg tcccactcgg cgaagagctg gccgagcgtg tagcgcttgt
    11161 cgtcggtggg cgcctcgatg tggatgacac cgcgctcatc gtgggtgtgc agctccgaca
    11221 tggcggtccc tgccgggtgg atgccgatgt tggccggcac ggtcaccggc tccccgtcca
    11281 cgatcacgtc gaggtgcgtg tggaagtgct cggccgttcc ctccatcgga gccacgcgca
    11341 ggctggcctt ctcggccaac gcgaccgggt cctccggcag aggccagggc ggaaggttgg
    11401 tcccctctcc gctcaccagc tcggggagcg gggtggtctt ctcggagtcc ggtagctggg
    11461 tgatccccca cccggcgatg ccgatcacga ggatgcccat ggccgcgacg gatccgaaga
    11521 ccaagacgcg cttgcgtcgt tccctgcgtg cctgctcggc ctgcatgagg gcgatcttct
    11581 cggctcgctg acgcttgcgc cgctgcttgg aagcgccagt ggaggtcgag gatgaggacg
    11641 aggagttcgt gtggccgcgc gacgacatga tcggacaacc tcctgacgag gggacgggcg
    11701 tgccaactat acctaaacac ctaaggtgta tgggtatagt tgcccgcgcc gcgataactc
    11761 gtacgccgcc ccacccggga tccgaccccc gaggaggtct ttctccgatg cctctgcctc
    11821 tcatgccgcc acgcgcccgc ctgggcctcg caggagcagt gaccgtgctc gttctcgctg
    11881 ggtgtgccgc agattcggac accgacgcgc ctaacccaac ggcctcggct tcttctcccg
    11941 cgccgtcctc cgagaacgac tcctcgtccg gccatgggca caagcacgag atgcgggagg
    12001 ccgagggagc cccggcgcct tcggtgagca tgcaggtgag cgaggaccct gtgtcgggct
    12061 ggaacgtgcg gctcaaggtc aaggagttcg ccttcacccc ggagcgcgcc ggcggaaagc
    12121 cccgtgacgc ggaaggccac gcccacctgt acgtggacga cgagaaggtc gcccgtgtct
    12181 atggctcctg gtaccacctc cccgcctcgg ccgtgcccga gggcgagcac accctgtcgg
    12241 tgcggctctc ggccaacgac cacagcacct ggggcattga cggaaagccg atcgccgaca
    12301 gcgccacgat cacgggagag ggcagtgacg gctcatctgc gtcctccgac accgacaacg
    12361 acagcgaagg tgacgccgac gtcaccgccg agatcagcgt gagcgacgga tccgtctccc
    12421 ccgagcccgg tcggctggag gtcgagaagg ggcagcgggt gcgcatcgag gtcaccgctg
    12481 ataccgctga cactgtccac ctgcacggtt acgacatcgg ggaatcggtc gggcccaaga
    12541 agccggccgt cctcaccttc accgctgatc aggccggggt cttcgagctg gaaacccacg
    12601 actccggact cctcctcacc caggtcgcgg ttgaatgaac ccgaatctcg gcctcgctgt
    12661 cgatctcgcg cacggtatcg gcggacgcga cgacctgcca ctaccgctct cacacgccct
    12721 gaccggcgcg gccgtcgccg tcgtcgtgtc gttcgtcgcg gcggggctgc tctggcgcac
    12781 accgcggcgg cccggcgaca ccgcggggcg cccgctgccg ccacgcctcc aatcggccct
    12841 tgacgggccg gtgatccgct gggggctgcg cctgctcggg ctcgccgcag ccgtcttcgc
    12901 cgcggtagcg gcggtgctcg ggcggaacga cgcgctcaac ccggtgccgg ggttcgtcta
    12961 cgtgttcctc tgggtcggac tggtccccgc ctcgctgctc ttcgggccgg tgtggcggct
    13021 gctcaacccg ctgcgcaccg tccacctgct cctggcccgc ctcacacgca cccctcccga
    13081 ccgcgggcta tggcgctgcc ccgactggct cgggtactgg ccggcggcgg ccgggctgct
    13141 cgccttcacc tggttggagc tggtgtggcc gcacagcacg gatctggcga gcctgcgact
    13201 gtggttcgcg gcctacgcgg ccgtgcagct cctcggtgcg ctggcgttcg gaaaccggtg
    13261 gttcgaccgc gccgacgcct tcgaggtgta ctccaccctc atcgggcggc tcgccccgct
    13321 gggacgtcgc ggcgacgggc ggctggtcct gcgcgggccg ttcagcgggc tcgacgggat
    13381 gaagccggtc gcgggcatca cggcaacagt gtcggtgatg ctcggttcca ccgccttcga
    13441 cagcctggcc agcgcgccgt ggtggatcgg ctacacccag accgtccccc tgcccgggct
    13501 gctcaccgga acactcggcc tggtcggcat ggcgctgctg gccgcggctc tgctgtcggg
    13561 aggcgcgctc ctggccggcg tgatcggggg gcggagccgg gccgggctgc cgtcggcgtt
    13621 cgccccctcg gtcatcccgg tggccacggg ctacctgatc gcccactact tctcactgtt
    13681 cctgttcgag ggccagcgca ccctcatcct ggcctccgac ccgctgggca ccggcgcgaa
    13741 cctcttcggt accgccgagc gcggggtgga gttcagcgtg gtttccccgg agacgatcgc
    13801 gttggtccag gtcggcgcgg tggtggccgg ccacgtcgtg ggcgtggtcg cggcgcacga
    13861 ccgggcgatc cggctgttcg cggcgcgccg ggccgtgctc acccagctcc cgctgctggt
    13921 gctcatggtc gcctacaccg ttggcgggct cgccctgctg ttcgccacgt gagcgcctcg
    13981 gtggcgtgtt tctcgggggt gcgggccacg gcacacagga caacgcctaa tctgtttagg
    14041 tggcagggat tcgcgcagtg acgtgggacg acggagggcg aaggccatgg ggcgcagcac
    14101 gcggctggtg atcacggcgg ccgcagccat cgccgcgctc ggtgtcacca ccgccgtggg
    14161 cgccgtgctg ctctccgagg gtcgcggcac cgagcgcgtt ccgtcaccgg aagccacgag
    14221 cgcgcctacc ggagtcaccc ggtacgccct ggcggagcgt cccgacgcgc cgccactggc
    14281 cgggccgcgg ctggacggcg ggcggatgga tctcgacgca ccagacggtc agggccaagt
    14341 gagcgtcatc aacgtctggg gatcgtggtg cccgccgtgc cgcgaggagg caccggatct
    14401 ccagcgcgtc tgggagggcg tcgagagtga cggagtgcgg ttcatgggcg tgaacacccg
    14461 cgacaccgag gcgggcgcgg aggcgttcgt cgaagagttc ggcgtcacct acccgagcat
    14521 cgtcgacccc gacggcgatg ccctgctcgc ctggcgtgag atcatcccgg tccaggcgat
    14581 cccgagcacc gtcgtggtcg accgtgaggg gcgggtggcc gcccgtgtga tcggccccgt
    14641 tgacgccgcc accctgcgcg gcctcgtcaa cgacatcgtg aacgaaggga agccagcaca
    14701 gtgaacctcc cccgtcgcgg caggacccga cccgccggtc gtcacggtca ccctcgtcgt
    14761 cccggtcgca tcggtgcggc ctccgcgctc gccgtcgcac tcgccgccgc agggtgtgcg
    14821 gccccaggcg gggaggcgac gggtgacagt cccttgaccg tcatcgacgg cgagtccaac
    14881 aacggctacc acggcaacta catggagccg ccctaccaga tgccggcgct taccttcacc
    14941 gacacctcgg gccgggactt cgacctggca aggacaccac gaagcccctg accctggtgt
    15001 tcttcggcta caccaactgc cccgacgtgt gtcccaccgt cctggccgac gccgcggcgg
    15061 cgatccgccg catgcccgag gaacgcaagg acgacgtgga gctcgtcttt gtcactaccg
    15121 accccgaccg cttcgacccg tcgttcgtcg gcctgactgg cgacatggac acgattgagc
    15181 aggcggccga cgacctcatc gtggagatcg agccgaagga agagcaagcc gacggcggct
    15241 acaccaccga ccacggatcc catgtcatcg gcttcgacgc cgacgatcag ggctggctcc
    15301 tgtggacgcc cggcacaccc gtgggcgatc tccgcgagga ctacacccgc ttcctcaccg
    15361 agttccccgc ggactaggcg cggtctgtcg gggccactcc tcgcggttgc gcatcagcac
    15421 atcgagacgg cgctcgaact ccccgtgatc gacctctcct cgggcgtaac gctccttgag
    15481 catctcaatc ggcccgtcga cgaccggcgg aggcgactgc cggtgccgaa cagtcggcgt
    15541 ggcgagagtg gtgagggccg tgttccgcag gaccaggatg gcgacagcga tgacgaccgc
    15601 gacggtcagc agcggcgcca gcgtggtcgc gacagcctcg gcccacccgg tctccgctcc
    15661 cgtcatgccg tggcatccca tcatgctggc cccttttctt cgcgaggtgc gtgccgtccc
    15721 gccgaaccgg gatccgaccg ctcatgagcg accggccacc tcttctacct aagaacctta
    15781 ggttattggc tgctgtcagc gcagctcaag atcccccacc tttcatcgct gtgctgccgt
    15841 accgcccttc acagagaccg gcaggccgcg cgtccgagag ctcgtggtca cgccttgggg
    15901 gagcgctgga gccattggaa ggagggagcg ccgtagccgt cgggctcggt cggggaatcg
    15961 gggccgaatt cgagggcgca gtcggcagcc agttggatga tggtgcggcg cacttcgaga
    16021 ttggcctgcc agtggccggg gaagacggtg ctgccgtacc gggcgccgag gaggttgccg
    16081 cagatggcac ccgtggagtc gctgtcgcct gagtgattga cggccaggcg gaggccgcgg
    16141 cggccgattt cggcggggcc tctgcgagag gagtaggggt tcggtgggtc gttgaccatg
    16201 gacagctcgg cggacagggc ggcgtagacg cccatggcca gggcctcttc tccggtccag
    16261 ccacttccta gccgttccag ctgttcaggc cttggtgatc cctgcctcgc gagcgtgatc
    16321 gcggcgtcaa gtgccttcga ggtctcctcg tgcccttgcc gctccatgag ttcagcgcgt
    16381 gccagctcca gagccgaatc caactgcgcg ccgcggacta gagaccacac ggtagcggcg
    16441 agtacgcccg ccgacaggta gccgctgggg tgtccgtgtg tcagagctgc cgcgcggcag
    16501 cccatgtcga aggcgacttc gacgctgatg accccgaaac cgcagggggc ggcacgcatg
    16561 acgccgccgc aacccttgga gtcgttgatc ggttcgtcga ccgtgcccag gggccacccc
    16621 ggcttctgcc gctccgcggc cttgtgcagg gccgacaggc aggtcttacc ggggccgcgc
    16681 cgggacatca tcacgttgtc ctgacccaac cagccgtagc ccccacccag cccctgctcc
    16741 gggatgtttt caccctgccc ccgcaaccac accaggtagg actcttgcag catcccgatc
    16801 gccgcgccgc cgatcccttt ggcgcgttgc cgcaccgacg cctggatcaa ggcctgcgcg
    16861 gtgaacgcca tcatctgcgt gtcgtcggtg atcgctccga cgccgacccg ctcagggctg
    16921 tactcggtga gaccgtcggg gccgtacttc tccctgatct gcgcgatggg gatcccctcg
    16981 atcggcgccc ccagcgcatc accgatagcg ccgcccagca ggcagcccag caggcgatcc
    17041 ggatcggggt cggggaggag gcgcggcatt gtcgacatcg tggaggagcc catgcgggag
    17101 agtatggcag cggcctcaga cacggccgtg tacccggtcg ctgccgtact ctcccgcatg
    17161 ccagtcacgt ttcccgccga tccggacccc tcgcccctcg tccgtcggcc tcgtcatggg
    17221 cctggcaaac actccccgcg ggaggagagg cgctaacgcg cgccacctcc gaccgtgacc
    17281 gaatcggtgg tcaggcggcc atcccgcatg cgggagaccg tgtcggcccg gtccagatac
    17341 tcggtgtcgt gggtgacgac gaccgtggcc acgttgtact cgcgggtgat ctcggtgagc
    17401 aggtccatga tctgcgctcc ccggtcgtgg tcgagggcgg cggtgggctc gtcgaccagg
    17461 agtacctgcg gctcgccggt cagcgcgcgg gcgatgttga cgcgctggcg ttcgccgccc
    17521 gacagctgcg ctgcgcgccg gtgctgcttg ccgtccaatc cgacgatcgc cagcaggtgt
    17581 tcggccgcct cccggcgctt tcgcgccgac cgccctcgca tgtgctcggt gaccagcagc
    17641 tggtcgaccg cggtgagcga ggagatgagg ttgggctgct ggaagacgat gccgatccgg
    17701 ctcatccgca gtcggctcag ctgggcggga gatagagacg tggcctcggt gccgtcgatt
    17761 cggacactgc cggaatcggg gcggatcagc gtcgaagcga ctgccagcag gctcgacttc
    17821 cccgagcccg atggccccag gaccgcgtgc agctcgccgg ggcccacctc tagggacacg
    17881 cggttcaggg cggtcacggt ggagtcgccg tcggggtagg tcagcacgat gtcggtcagt
    17941 tcgatgctca tcggacgcct ccaagggcgg tcagcgggtc gacggaggtg atgcggcgga
    18001 cggacaggac cgccccgagc atgccgagga cgaccatcgc ggccaccggc aacacggtgg
    18061 tcgcgaccgt cagcgagaac ggaacgacgc gctcggctag gacccccacc ccgaatccgg
    18121 cgagcccgcc gacaccggcg cctgccagga gcaccagcag cgcctgcgcg agggcgtcgc
    18181 gcagcaggta accggtcgag ccaccgagcg ccttgagaat ggcgatgtcg cccgaccgct
    18241 ggatggtcca caccgtcagg aaggcgccca cgaccagggc ggagatggcg tacaggaacc
    18301 cctggatcat cagtagcgag ccgttctcgg aggagaacgc gccgatcgcc gacaggctgt
    18361 cggagcgggt ggccgacacg gtttcggcgt cggtgtcgat ggccgccgta tcggcggggg
    18421 cgtgatcggc gcccatgccg atcgcgatca ccgttccggc aggggagccg ttggccgtac
    18481 cggatggggc gaaggagcgc caggtgtcca gggacgtcca caccaccggt gtgtggctgt
    18541 agctgtcgtc ccgagctatg cgggtgatgg tgaggtcggt gccgccgagc gtcaggacgt
    18601 cgcccacctc cagccctttc tcatcggcca gcgaacgccc gacgaccagg ctgtcgtccg
    18661 cggtgccgtc aggcgccagg tcctcgcccg gctcggcggc gaagatggtc gcggcggttg
    18721 tggaaccgtc cggcgcctcc acccgggttt gggtgatgcc cagcggttcg gcccaggcga
    18781 cgccctcggc tcccgcccac gtgtcgacct gatctgcggt gactgagctg tccgcgaacg
    18841 actccttggg ttcggagtcc ccggcggcgc cgaaggcgat ccggtcggcg ggcaggcggt
    18901 cgacggcgga gacggactcg gcggcaagtc ctgcggtgag tcccgacagc aggacgacca
    18961 gcagggtgat gagggcgacg accgagccca tcagcgcgaa ccgccccttg gcgaagcgga
    19021 tgtcacggat ggctacgaac acggatgtct tcttccaatg cgggtgaggc cttttcagtg
    19081 cttcacccac gatcgcgacg cggagcgcgg attccatcgg ggcgacggat ggttctgcgg
    19141 agcgagatgg atgatcgcgg catcaaccgt tcggttgatg cctggtggga cgcgagacgc
    19201 ctaacgtgag agggatatgg ataccgctca ccaggcgccc ttctcctcgt tcagtacggg
    19261 gaccgtgacc gtgctcgcgg taatgagggc gtgcctgcac gcggcctttt tcgtcctcct
    19321 gggcgtcgct gcgctgcgcc tcttcaccgt gcgcgaggcc gggcactgga gctgggcggc
    19381 gcttgtcggc gccgcgctgc tcgccgccct gtacaccagc gggccgttgg tgatgcgtcg
    19441 gctgccgccc ggccgcctcc ccgcccgttc cgccgcgcgg gtgtggctgg cgctggtcac
    19501 tgcgctgtgg gcgatcctgc tgctgatcag cccggacttc tcttggctgg ccttcccgct
    19561 gttcttcctc catctccacc tgctgcgccg ctaccacgcc gtggtcgcgg tggccgtgat
    19621 caccggcgcg gtcatcgcgg cgcaggcgct gcacgcccgc gacatctccg tcgccatggt
    19681 gctggggccg acgctggggg ccgccttcgc ggtcgtgatc gccctggggt actccgccct
    19741 ctatgcggag agcgagcagc gccggcggct gatcgacgat ctccggcgca ctcaggacga
    19801 actcgccgac tcccagcacc gcgcgggcgc actcgccgag cgcgagcggc tcgcccgcga
    19861 gatccacgac accctggccc agggactgtc cagcatcgtc ctgctgttgc ggtccgccga
    19921 gggagctgtg cgagccgatc cggacgccgc ccttgcccgt atcgctgagg cccgggagtc
    19981 cgcatcggag aacctggacg aggcgcgtgg attcgtgcgc ggcctcgccc cgcccgcgtt
    20041 ggcgggtggg ggctcgttgc ccgatgccct gcggcggctg tgctcgcgcg tggcggcggc
    20101 gagcgggatc gactgccaat gccgggtgga aggagagccc gtgccgcttc cggccgacta
    20161 cgaggtggcg ctgcttcggg cggcgcaggc cagcctcgcc aacgtcgccg cgcattcggg
    20221 cgcgagcacg gccgtggtca cgctggcgta cctgggcacc gaggtgaccc tggacgtatt
    20281 cgacaacggg cgcggattcg acccgactgc cgtgccgcag tcccgttccg acggcaccgg
    20341 atacgggatg cgggcactcc gtgaccgcat caccgcgctc gggggccgtc tccacatcga
    20401 atccgctcca ggggagggca ccgcggttgc cgtggccctt ccgttcgtcg ctgagaacaa
    20461 caacgcgaag gaggaggagt gagcggcgga ccgctgcgga tcctgctcgt cgacgaccac
    20521 cccgtggtgc ggcgcgggct gcgcgcgatg ttcgacgagc gcgaggatat ggaggtcgtg
    20581 gccgaagccg ctgacgggcg ggaggccctg gatgtcctcg acacggccgc cgtcgacgtc
    20641 gtcctgatgg atctgcagat gggccagggt atggacggcg tcagggccac ccggaccatc
    20701 agcgagcgcg cggacgctcc gcccgtactt gtcctgacca cctacgacag cgacgc
//
