LOCUS       NZ_NDXL01000002        26445 bp    DNA     linear   CON 27-APR-2024
DEFINITION  Streptomyces kasugaensis strain BCRC 12349 scaffold2, whole genome
            shotgun sequence.
ACCESSION   NZ_NDXL01000002
VERSION     NZ_NDXL01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces kasugaensis
  ORGANISM  Streptomyces kasugaensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1748118)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Comparative genome analysis for kasugamycin overproduction
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1748118)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. May-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 188.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002261115.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 02:42:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,951
            CDSs (total)                      :: 7,863
            Genes (coding)                    :: 7,657
            CDSs (with protein)               :: 7,657
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 4, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 206
            CDSs (without protein)            :: 206
            Pseudo Genes (ambiguous residues) :: 0 of 206
            Pseudo Genes (frameshifted)       :: 87 of 206
            Pseudo Genes (incomplete)         :: 170 of 206
            Pseudo Genes (internal stop)      :: 23 of 206
            Pseudo Genes (multiple problems)  :: 65 of 206
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:37:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1441532
            Orig. end                         :: 1467977
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NDXL01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26445
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26445
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26445
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16445](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16445
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(264..282)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.5"
                     /tool="antismash"
     gene            complement(848..2089)
                     /gene="fxlM"
                     /locus_tag="B7024_RS28235"
     CDS             complement(848..2089)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054574.1"
                     /locus_tag="B7024_RS28235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_094794143.1"
                     /sec_met_domain="PCMT (E-value: 2.1e-40, bitscore: 135.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEVTADSASAAELRDRLVNELVAQHTIESKEVEEAFRKVPRHLF
                     APGAPLEKAYAHAVVATKCDANGITISSVSAPEIQATMLEQAGLRPGHRGLEIGSGGYN
                     AALMAELVGTGGEITTIDIDAEVTDRARACLKGAGYARVNVVLTDGEEGCAEHAPYDRT
                     VVTVGSWDIPPAWVDQLAEGGTITVPLRMGGLTRSITFVRAGDRLVSQSAKICGFVTMQ
                     GAGAHRERLLLLRGKEIGLRFDDEWPADPDLLNGALDTERVEVWSGVRIPRGEQFDTLQ
                     MWLATALDGFCLLAVDPKLDTGLVSPQNKMACPAVVEGGAFAYLTLRKLGEEPDPVFEF
                     GAHAFGPDAATLADAMAEQIRVWSRDHRGGPGPSITAYPADTPDEQLPEGRVINKRHVR
                     VLISWPSEGLSPAS"
     misc_feature    2183..2198
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            complement(2394..2522)
                     /locus_tag="B7024_RS43210"
     CDS             complement(2394..2522)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS43210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_280530318.1"
                     /transl_table=11
                     /translation="MITDTELDRFTRYCLTRRGRIATDAGCGSGAFTRRLHHSGFD"
     gene            complement(2519..2806)
                     /locus_tag="B7024_RS28240"
     CDS             complement(2519..2806)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS28240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094794145.1"
                     /transl_table=11
                     /translation="MRHDDTRREVVAEPARPVDDGTTVSLLDRLHDSFVNDEDLDDDLD
                     LILSLESALLTAKDAERLTPQPLQDGRAGIRVRLPSRAGTPGSKTARPYG"
     gene            2826..3032
                     /locus_tag="B7024_RS28245"
     CDS             2826..3032
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS28245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094794147.1"
                     /transl_table=11
                     /translation="MWHSCHGLPGSAELDPHVLAFGVRAGAPGVEAAQARWRAISGAHL
                     VALVRAGARFENGVLVERDELAA"
     gene            complement(3210..3683)
                     /locus_tag="B7024_RS28250"
     CDS             complement(3210..3683)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963923.1"
                     /locus_tag="B7024_RS28250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_094794148.1"
                     /transl_table=11
                     /translation="MKSLEMKPIGTVVGGRTEPLDDQWSGTAIIRLNPDFPLDVVQGLE
                     EFSHLLVVWHFHLASPDDVALHARSPRNNPQWPSTGTFAHRNHRRPNQLAQSFPRLLKV
                     DGLDLHVEDLDAVDGSPIYDLAPYFQEMGPRGEVREPVWPREMLANYWADSRG"
     gene            complement(3717..5105)
                     /locus_tag="B7024_RS28255"
     CDS             complement(3717..5105)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662459.1"
                     /locus_tag="B7024_RS28255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Tat pathway signal protein"
                     /protein_id="WP_094794149.1"
                     /transl_table=11
                     /translation="MAERRRNERLAALLEEAGWSRAQAASAFNRVVQESKVPDYASIGR
                     SHITMWVGGTRPSGAAPVILCQALTRRLKRLITPEQLGFASPHTPTQGTLDWDVDPLIS
                     LTDLGRMDLDADRRKFIGGAVYSVAALALPREQWWQAMAKPPQSTPSRQQHVGRADVTM
                     VEELTVAFSRMDQQRGGGHGRKAVVQYLRSDVASLLRGKFPNEQVRGDMFSAAGELAYL
                     SAWMAFDNAEHAVAQRYFLLAAKLAARADSPPLVGHILRAMAHQALDLGFFKESLELSS
                     ASVEGQRYVSATPRERSLLGVVHARGLAANGQKRAAARALLRAENDLASAQDGVPEPHR
                     TFFFSDAALAHETACTLRDSGDRPGAIRHFRQSIRTRGAAFRRTHAVTLGYLGATQINN
                     GSVEEACATWSGLLDAMDEGIYSGRARQAVFDMRKLLSPYRHRAIPAAMELDARAVSYL
                     TRVD"
     misc_feature    complement(5067..5069)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5126..5135
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            5440..5712
                     /locus_tag="B7024_RS42800"
     CDS             5440..5712
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS42800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094794150.1"
                     /transl_table=11
                     /translation="MAVAATGVEILAKRSLGSVAESLPTVLDDLTLTVKRTPVQDGADS
                     AVVTGVWVRHLRRIGAAKLRYWGFSAQVDDAVLLISELVTNACAP"
     gene            6237..8039
                     /locus_tag="B7024_RS28265"
     CDS             6237..8039
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019076035.1"
                     /locus_tag="B7024_RS28265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="reverse transcriptase/maturase family protein"
                     /protein_id="WP_172451032.1"
                     /transl_table=11
                     /translation="MQSAEAVLDVLRERGRRGLPCDELYRQLFNPNLYLLAYGRIYANH
                     GAMTPGACGETADGMSEAKIGRITEAMRHERYRFRPVRRVHIPKSNGKTRPLGLPSWSD
                     KLVGEVIRLLLEAYYEPRFSGRSHGFRPGRGCHTALSEVAHKWTGTTWFIEGDISDCFG
                     SLDHEVLLAILSEKIRDNRFLRLIQQMLKAGYVEDWKWHATLSGSPQGGVLSPLLSNIY
                     MDRLDTFVETVLIPEYTRGTSRRKNPEYQKLENAIWNTRQRLAKRKEHTESAQVRQWRK
                     ELRRHPVGDPHDPDYRRLRYIRYADDHLLGFTGPKAEAETIKQRLAAFLRDDLKLELNQ
                     SKTLITHGRTQAARFLGYDITVQHADAKVSRGGRVNRGMRSINGKVSLRVPKDVIKAKC
                     APFVKHGKPAHLDPLTGCTPFDIISLYGAQYRGIVQYYLLAGDVWKLDRLKGVMLTSLL
                     KTLAAKHRSRVTTMANRYKTTIKTPQGPRRCFEARIEREGRKPLVARFGGIPLTRKRTA
                     VLDDLPSTMFTPRSRPRGSQLIDRLQRGRCELCERRTEVQVHQIRSLAELHGREERPAW
                     ALLMLKKRRRTLVVCPPCHGGIHA"
     misc_feature    7083..7085
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8079..8095)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.48"
                     /tool="antismash"
     gene            8418..8849
                     /locus_tag="B7024_RS28275"
     CDS             8418..8849
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS28275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094794152.1"
                     /transl_table=11
                     /translation="MTPSALAVLSAPGGVPESGSRFSNDVGTQTRVLAKLREHALEGSK
                     EIPVLDELFEDLEAVLGECADLGEDDVERLRPRVHASLRRVLGAAEKANLAIPTATVKR
                     GRDLLSDPLLADLRPVRGHLRHLATVTAELLDWLLEDMP"
     misc_feature    8829..8831
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8846..9310
                     /locus_tag="B7024_RS28280"
     CDS             8846..9310
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571583.1"
                     /locus_tag="B7024_RS28280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6302 family protein"
                     /protein_id="WP_216362867.1"
                     /transl_table=11
                     /translation="MTSSVDLLPAEHAYDFDYFSVRLENHQLLHSSVAVRVFRAPLLAV
                     PVGGRRRGGYFSASEVSIGLAIRNALAGTPGFPNTKLRRALFPDCCHVVEWGETPPDTE
                     SDVALGRFYGYSERAIAAHVHQNLSPTRPRRSHIDAFGLSRDQRGKNGRS"
     gene            9307..9516
                     /locus_tag="B7024_RS28285"
     CDS             9307..9516
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS28285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216362868.1"
                     /transl_table=11
                     /translation="MNACETHGPDSRIDRIYTTSELLGAVVSVDVIEVPEEISDHHIVR
                     LTLDADRPADILDGQPGVLQPTAA"
     gene            9738..9914
                     /locus_tag="B7024_RS28290"
     CDS             9738..9914
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143559.1"
                     /locus_tag="B7024_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_094794154.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1e-12, bitscore:
                     44.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPSITHATKASPQPAQAATDGFELDVTLVEVSDTAGLISLTNDG
                     CGETCGACTTNVA"
     CDS_motif       9738..9845
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSPSITHATKASPQPAQAATDGFELDVTLVEVSDTA"
                     /locus_tag="B7024_RS28290_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9846..9914
                     /prepeptide="core"
                     /locus_tag="B7024_RS28290_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.80"
                     /molecular_weight="2010.2"
                     /monoisotopic_mass="2008.9"
                     /core_sequence="GLISLTNDGCGETCGACTTNVA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSPSITHATKASPQPAQAATDGFELDVTLVEVSDTA"
                     /leader_location="[9737:9845](+)"
                     /alternative_weights="2028.2"
                     /alternative_weights="2046.2"
     gene            10001..13072
                     /locus_tag="B7024_RS28295"
     CDS             10001..13072
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612044.1"
                     /locus_tag="B7024_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_094794156.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.9e-195,
                     bitscore: 645.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.8e-19,
                     bitscore: 65.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-19, bitscore:
                     67.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRTAFRAGKTALLRAVARPELPVPPCPDLDDPSPRGAAARLAW
                     LREVWFEEDVAEALEHASPALASQVRALCSSGDPAARDVRRAVASVARYVLRAEHRATP
                     FGLFAGVASAAIGPRARTLWGSDDTVVGRASAEWLTAVVERLESCPALLERLLVVVNNT
                     TAKRGDRLIVPYKSDPHGDRRRVVEASVALTRPVRAVLDASRKPIPAGVLADKLSAEFP
                     GAGLGKIQRLVRELVQYEVLITNLHAPSTETDALQHLLGQLDAVGAGSVAPVADVVRDL
                     HAVQVDLSGCGSRSGRARAAARMRAQVPGLKRHPLALDLRLNAQIELPEAVAQEIERAA
                     SVLTRVSAHPYGTAAWKAYQRRFYERYGIGTMVPLNEVVADSGTGFPDGYPGTQATEDR
                     SRLSVRDDTLVRLAQAAALDGCEEVVLTDDLIAAMDLGPERPRVPPHLEVGVRVHAASV
                     EELHRGRFRLELASVSRGVGVTTGRFLSVLAPEDREGLSAELADLPTADAGTIAAQLSF
                     PPLLSTSAHVTRAPQVLPTVISVQEHRATSSDVLTPHDLAVACDGRRMYLAAPELGHRV
                     EAVGMHALNLTTHTPPLVRFLTELSRAQCAQVTLFDWGAASAMPFLPRLRYGRTVLAPA
                     RWRLEAADLPGRDHPQAQWDTALEEWRARRRMPQRVVLAEEDRRLHLDLGQAGHRTLLR
                     QHLNRVRLAIFVEAPAADAYGWSDGRAHEVVMPLKATRPPAWPHLPTPAPARTLSPEQI
                     QTPGVSSLLLTTLYGDLRRQDILLAQHLPVLLDQLGGPPWWFIRFRDPDQHLRVRIALP
                     DPDAFAETIRTIGTWADELRGDRLLSDMRFPTSYCEMGRWGSGEAWNAAEAVFRADSHA
                     VVAQLTQSQRPQHRALVAAHAIAIATAFLGSTEEGMRWLIEHIPPTAPATVSRPQFTEA
                     VRLADPSGDWAALRGVPGGHTIVEAWADRNEALAAYRPHLPGPDTQGIRLDDVLSSLLH
                     VHFVRHVAVDFTEEEICLYLTRAAALAWMSRRAR"
     aSDomain        10472..10747
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7024_RS28295_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-20"
                     /identifier="RREFam001.1"
                     /label="B7024_RS28295"
                     /locus_tag="B7024_RS28295"
                     /protein_end="249"
                     /protein_start="157"
                     /score="65.0"
                     /tool="antismash"
                     /translation="VVVNNTTAKRGDRLIVPYKSDPHGDRRRVVEASVALTRPVRAVLD
                     ASRKPIPAGVLADKLSAEFPGAGLGKIQRLVRELVQYEVLITNLHAP"
     gene            13069..14340
                     /locus_tag="B7024_RS28300"
     CDS             13069..14340
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="B7024_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_094794158.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-45, bitscore:
                     151.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLALKTVDAVADLLAYPATAPMGPDASLHRQHLAYGPTGIAL
                     LHIERAAAGMGPWQRAHEWLTAAARQPFTSGPDSHPFYGAPALAYAMACVADHLPGAYQ
                     RARGILDRQMGADSRRRLEAAHRRIDRGCLPEYAEFDTIRGLAGYGAYFLRRDPSGAHV
                     SAILDYCVRLTEPVTYGGEVLPGWWTLSGPSGRQDDRFPGGHANHGMAHGIGGVLALLA
                     LAARRGITVGGHREAIRTILAWLDRWQEKTDRGEAWLYWVTRDELRTGRPDPSPPRRPS
                     WCYGTAGLARARQLAALALGDTDRQIEAENALVSALTDRAQLKATTDNGLCHGFSGLAH
                     IAARIADDAHPSTAGQLRAAIPPLLNAACPPGTVPEDTARSVIQDEEAGPGFLNGAAGM
                     ALALLGPATTAPPQSAWDTCLLIA"
     gene            14364..16445
                     /gene="fxlM"
                     /locus_tag="B7024_RS28305"
     CDS             14364..16445
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="B7024_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_094794160.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.3e-26, bitscore:
                     89.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 5.9e-47, bitscore: 156.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDRWHQHNVTFADRASGKRAIADRLGPALLAAEEDGQLTGWWF
                     MNKQPWPLRYRSAEPSARVESLLSDLVHGGTVRSWLPGIYEPETAAFGGTQAMDAAHEL
                     FHQDSRHLLTYQPGTGRLGRRETAVLLISAMMRAARLDWFEQGDVWAKAAALRPAPEEL
                     PPDRAAALGTAIKRLMTVDTRSLCRPTGPLEGHDEWVAAFERAGTTLAHLATGGGLTRG
                     LRAVITHHLIFHANRAGLLPDDQSALFHLAREAVMGSSDNTASSAEGTPETTSVRAVNT
                     DTLATSEAHAAQLRNTLVDKIRESGYARTPAVETALRTVPRHLFVPEATLEDAYANTVV
                     NVKFDTDGTSISCASQPQIVAIMLDQLDAQPGERILELGAGTGYNAALLAHLVGETGHV
                     TTIDVDDDLVEGARAHLAAAGFTNVEALTRDGAVGYAEGAPYDRIIATVGAHGVPHAWM
                     QQLAPGGRLVVPQRLKGSVSRSIAYEERDGRWTSVSSKMNTFMPLRRGIADDDRPVIPL
                     SVDGTVRLQTSAGRPIDAGALAGVLEQPRTEEWTGMMVRVMESPEWMELFVSCSMPSGL
                     MRMLFPKDAKGTLLTEDPYPSSTAVVDKGAVTYLARRLSEKKTSEGGKLWEFGVIGHGP
                     GSAELAARVADAIRTWDREYRDREATFEIQPLDAPAIERAPGLFSLDTPLNRIVVDWR"
     misc_feature    complement(16483..16497)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            16547..17665
                     /locus_tag="B7024_RS28310"
     CDS             16547..17665
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345939.1"
                     /locus_tag="B7024_RS28310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_172451048.1"
                     /transl_table=11
                     /translation="MDPHGPIARRFPIVARFRPACLPLHARVTALVELAAKAVKQAEQG
                     VASAVFNQAALLASDIDLPDLARSMCHRHAEAYLHACPLPAVSAIRGLEPLVNLARLQI
                     RAGHNDDGRQRLLDLYEAVGAGRAAVFEGITVPANLTATGEDRREVHAWLWRVVLADGT
                     RSLTTTGRWPEALAHIEQHRGVGTRMLDGRQVAVLAALTEGDTDQAAELLLSTAPGEPW
                     EQAITACLTVLCRRYAGRPVDGQLTELVHIYLDREAASGLTVFDIRLGLTVLDAIPSAD
                     HPAVRRLVDDLIRRTIGARDGYAAREVLGHPLCVTLATETQTRDCRDLVTACALGARVL
                     PEELNTDLVGALDTSRAVLARTVTAPADTSVQ"
     gene            17714..18064
                     /locus_tag="B7024_RS28315"
     CDS             17714..18064
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039652.3"
                     /locus_tag="B7024_RS28315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6093 family protein"
                     /protein_id="WP_143682222.1"
                     /transl_table=11
                     /translation="MSASTEGLTMGAVSAIVERKILTDKIRIYRPGEPVFDPDTGQYKP
                     GLPVTVYEGQGAIFPTGERSAVLHIAGQAYVDDTPSRYRLLTPLSAPVSSREDTVTVVE
                     AEDESAIGRTWR"
     misc_feature    18089..18103
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            18291..18485
                     /locus_tag="B7024_RS28320"
     CDS             18291..18485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089681.1"
                     /locus_tag="B7024_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_094794164.1"
                     /transl_table=11
                     /translation="MADESAWFKSSYSNDTGGSCVEIADLNGKVGIRDSKDPHGPAFVL
                     PVGSWSNFIRAVTIGEFGN"
     gene            complement(18973..20346)
                     /locus_tag="B7024_RS28325"
     CDS             complement(18973..20346)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091147.1"
                     /locus_tag="B7024_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_107436906.1"
                     /transl_table=11
                     /translation="MPASPCRTAAAPYPPPARWALAAVATGAFCVQLDSFALNLALPVV
                     RAALPGSATAAPWVISGYLLAAGSLMPVAGRLGDLYGRRRMLRLGLAFFGTAAALCALA
                     PSLPFLVAARILQGAGGALIMPAGLALLTTSFPPGHGRRATGRALGLAGLATVCGPFLG
                     GALAEAVSWRAVFWLTVPLTAAAALCARRAAESRDPGPGHRLDLPGAAAATGALICLSR
                     WVEHGAAWGWAAGAALLGAAFVRAERRSRAPLVDLALFRNRPYVRLTAAGAVANSATVA
                     LLFAVPLTLQEERGLSVLGAGVAFLVPAAALAAGGPLAGRVRPAAAVPVMALCLATAAA
                     ALRSTGPGTTTPTLLAATTGAAAALGVAGGLALTGTQAVVHPARAGEASGVTKSALTLT
                     AGLGLTLTGTGPHPSLLGPAAVCLLASLALALPLVPGGVRAVRGATRGRRGTGADSDG"
     gene            20594..21115
                     /locus_tag="B7024_RS28330"
     CDS             20594..21115
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574400.1"
                     /locus_tag="B7024_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_242641191.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-15, bitscore:
                     52.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSEHAENARELQDQQASRIALTWTGEPGRMEEMTHGVLIEQAER
                     AAAALRRYGVRAGDRVAVHLPLVPESVIATIACGRLDAIRSSLPVSLTVPELAARLRES
                     GARVLITADAAFWDGAVRPVKALLDHALARGAGPDPVERRTVLVVNRCARPVSWTPGRD
                     RWWHEALDEV"
     misc_feature    20894..20896
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21390..22832
                     /locus_tag="B7024_RS28335"
     CDS             21390..22832
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015514 - nitrite efflux transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015707 - nitrite transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529896.1"
                     /locus_tag="B7024_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NarK family nitrate/nitrite MFS transporter"
                     /protein_id="WP_094794170.1"
                     /transl_table=11
                     /translation="MSPAVKGSPSQAAGPVPPEEFDPGQYRPGRTITDWQPENELFWKS
                     VGKKVANRNLWIAVPALLVAFVVWQVWSVTATNLKDVGFGFSTSQLFWLTAIPGLTGGT
                     ARIFYTFLGPIVGQRRFTALSTVVLIVPLIWLGFAVQNPDTPYVVMAAIAALCGIGGAN
                     FASSLANIGFFFPKREKGNATGINGGLGNLGVSVVQLVTPIVITSSVLALGSAQHKADG
                     TSVWLQNAAFLWVPVLVALAVVAWFGQNDLKVASTPFSKQKVIFRRKHNWLMTWLYVGT
                     FGSFIGFAAALPMLIKTTFTPIDAAYSAATYAWMGPAVGALARWAGGWLADKIGGARVT
                     ILSFVGMAVSIVGVINFLPSGGDNGSFWGFFGCFLSAFLFSGIGNGSTFRQIPVIFRDQ
                     HLKGQAEGTPGYAAALKQAEMEAGAVTGFTSAIAAYGFFFIPALFASISVTSAMWGFVA
                     FYVSCIAVAWWFYARKGAEAPS"
     misc_feature    22971..22985
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.64"
                     /tool="antismash"
     misc_feature    complement(22979..22994)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.31"
                     /tool="antismash"
     misc_feature    complement(22988..23003)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(23010..23029)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.64"
                     /tool="antismash"
     gene            23182..25440
                     /gene="pflB"
                     /locus_tag="B7024_RS28340"
     CDS             23182..25440
                     /EC_number="2.3.1.54"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /GO_process="GO:0015942 - formate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982918.1"
                     /locus_tag="B7024_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="formate C-acetyltransferase"
                     /protein_id="WP_094794172.1"
                     /transl_table=11
                     /translation="MTATPAEKTTSGEAWDGFKGGLWRDAVDVRDFVQQNYTPYEGDSA
                     FLAGPTERTTAVWAKLLGMFPQELAEGVHDVDVHTPSRIDAFEPGYIDKDLDLIVGLQT
                     DAPLKRAIMPNGGWRMVEGALNAYGYEADPQVREIYTHLRKTHNEGVFDAYTPEIRACR
                     SSGIITGLPDAYGRGRIIGDYRRIALYGVDRLIEEKKADKADADAQWPTEEVIREREET
                     AEQIKALGELKAMAARYGFDIARPAATGREAVQWLYFGYLAAVKEQNGAAMSIGRIDNF
                     LDIYLQRDIDAGRLTEAQAQEYIDDFVIKLRIVRFLRTPEYNELYSGDPTWVTWSMAGI
                     GEDGRPLVSRTTFRALQTLYNLGPAPEPNLTVFWSPQLPQGFKDFAAKVAIDTSAIQFE
                     SDELMRPKYGDDTAIACCVSAMAVGKQMQFFGARVNVAKALLYAINGGRDEKTGKTVVQ
                     GFAPIEGEYLDYDTVAPQYDAMLEWLAKTYVHALNVIHYMHDKYAYERIEMALHDRAIL
                     RTMACGIAGLSVAADSLSAIKHARVKVIRDETGLATDYEIEGEYPAYGNNDERADDIAR
                     SLVHEFMQKVRKHPTYRDALHTQSVLTITSNVVYGKKTGNTPDGRRAGTPFAPGANPMN
                     GRDEHGYIASAMSVAKLPYDDAEDGISLTNTITPDALGRTPQERVDNLAGVLDGFMASD
                     GFHMNVNVLDKATLQDAMEHPENYPQLTIRVSGYAVNFVRLTREQQLDVINRTFHGSL"
     gene            25571..26401
                     /gene="pflA"
                     /locus_tag="B7024_RS28345"
     CDS             25571..26401
                     /EC_number="1.97.1.4"
                     /GO_function="GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982917.1"
                     /locus_tag="B7024_RS28345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate formate-lyase-activating protein"
                     /protein_id="WP_094794174.1"
                     /sec_met_domain="Fer4_12 (E-value: 3.6e-14, bitscore: 49.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.2e-22, bitscore: 77.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 8.7e-07, bitscore: 25.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLLGSDIPVGAPVAWDPTNEPVTPAAAVQHRPISGSVHSWDLS
                     TGVDGPGTRFVTFLAGCPLACLYCHNPDTWKMRNGKRTSADEVVAEAAKYRTFIRAAGG
                     GATISGGEALLQPVFAGELLHRFRHELGLHTALDTSGFLGARATDAMLRDVDLVLLDIK
                     SWDRALYQRLTGRQLRPTLDFAHRLADLGTEVWIRFVLVPGLTDAPGNIEGIAAFAASL
                     GNVSRVDVLPFHKLGESKWDRLGMDFTLRDTPSPSPQQLAAAREVFAGHGLMAV"
ORIGIN
        1 gcccatctca ccggttcgct gcacgccggc ctggacaccc ggttcgccga gtacgccggc
       61 agcgtggtcg ccccgggcac cccgatcgtg ctgctcgccg accccggctc cgagacggag
      121 gcccgcctgc gcctcgcccg catcggctac gaccacgtcc tcggccacgt ccccgacccg
      181 gccaccgccc tggcccgcga acccgcgctg acctcccgca gcaaccgcat cacgatcgat
      241 caactcccgt cggaacccga ccaattgata gacgtccgca acccgtccga acacgccgcg
      301 ggtgccctcc ccaactcact caacatcccc ctggccggcc tcctcgaccg cctcacccac
      361 ctggaccgcg accgccccgt catcctctac tgccgcagcg gcaaccgctc agccatcgcc
      421 gcggcgctgc tggaggcgca cgggttcgac gaggtgtgcg atgtgctcgg gggctatgcg
      481 gcggtcgagg ccggagagcg ggagggggtt ggggtggggt gagggggagg gcggggcgag
      541 ggggagtggg gtgagccgcg ggggcaccgg gggcgcgcgg aggtggtgcc gggagggcgc
      601 tgacgcggtg ccgggcgtgt tcgcggagtt ccaccgtgtg ctggcccggg gcggccggct
      661 gctgctcgcc ttcaaggccg gcaacgagcg ccgctacctg gcgcgtgcct acggccacga
      721 cctctccctg gacgtccact ggctggcccc cgaccacgtc gccggccttg cggacgaggc
      781 cggtctcacg ccgtggcttc gatattcatg ctgttcgctc cttctggatg agttggtgcg
      841 ggttgcccta gctcgccgga gacaggccct ccgacggcca ggagatgagg acgcggacat
      901 gccgcttgtt gatgactctc ccctcaggga gctgttcatc gggggtgtcg gccgggtaag
      961 ccgtgatgct cgggccaggc ccgccgcggt ggtcacggct ccagacacgg atctgctcgg
     1021 ccatggcgtc ggcgagcgtg gcggcatccg gcccgaaggc gtgcgctccg aactcgaaca
     1081 ccggatccgg ttcctcgccc agtttccgca aggtgagata ggcgaaagct cctccctcga
     1141 ccacggccgg gcaagccatc ttgttctggg gggagaccag gcccgtgtcc agcttcgggt
     1201 cgactgcgag gagacagaag ccgtccagtg ctgtggccag ccacatctgg agcgtgtcga
     1261 actgctcccc acgggggatc ctcacccccg accacacctc aactcgctcg gtgtcgagcg
     1321 caccgttcag caagtccggg tcggccggcc actcgtcatc gaaccgcaga ccgatctcct
     1381 tgccgcgcag aagcagcagt cgttcccggt gcgctcccgc gccctgcatc gtgacgaagc
     1441 cgcagatctt cgccgactgg ctgaccaggc gatctccggc tcggacgaag gtgatcgatc
     1501 gggtcaggcc ccccatccga aggggaactg tgatggttcc tccttcagcg agctggtcca
     1561 cccaggccgg cgggatgtcc cagctgccga cggtgacgac cgtcctgtcg tacggggcat
     1621 gctcggcgca tccctcctcg ccatccgtca gtacgacatt cacgcgggcg tatccggccc
     1681 ccttcagaca ggcgcgggcg cggtcggtga cttctgcgtc gatgtcgatg gtcgtgatct
     1741 caccgcccgt gccgaccagc tcagccatca gcgcggcgtt gtagccaccg gaaccgatct
     1801 ccaggccccg gtgaccggga cgaagccccg cttgctccag catggtggcc tggatttccg
     1861 gcgcggacac cgagctgata gtgatcccgt tcgcgtcgca cttcgtggcc acaacggcat
     1921 gggcgtatgc cttctccagg ggcgctccgg gggcgaacag atgccgtggc accttacgga
     1981 atgcctcttc gacctccttc gactcgatcg tgtgctgggc cacaagctca ttcacgagcc
     2041 tgtctcgcag ctcagctgcg gaggccgagt cggcggtcac ttcggtcacg cgctgttccc
     2101 ttcttgcact gcactgggtg gtgactgact tgcggttgca cgaggtcacc tctggtgggt
     2161 caggtcattg ctgtcgaaca actccactgt gttttcaggt gtgttgaccc ttcccagcgc
     2221 ccccttcggg aggttagtca ctgggttgct ccatctcggc ctagctcgcc gacccgaccg
     2281 tgggatctgt tgattccgac agagtgacgg ctgggaatgt ccgaaagccg gtcgccaccc
     2341 agagcgagtc ccacgatgtg gtggcctgag ggatcgaggc gcacctccct tggtcaatcg
     2401 aatccggagt ggtgaagccg gcgggtgaag gcgccgctac cgcagccggc gtcggtggcg
     2461 atccgcccgc ggcgagtgag gcagtagcgc gtgaagcggt cgagttcggt gtcggtgatc
     2521 atccgtaagg tctggccgtt ttgctcccag gcgttccagc tcgtgacgga agccggacgc
     2581 ggattcccgc tcgaccatcc tgcaaaggct gaggagtcag ccgttcggcg tctttggcgg
     2641 tcaggagtgc agactccagg ctgaggatca ggtccaggtc gtcgtcaagg tcctcgtcgt
     2701 tgacgaagga gtcgtgcagc ctgtccagca ggctcaccgt cgttccgtcg tctacgggcc
     2761 gtgcgggctc ggcgaccacc tcgcgccggg tgtcgtcgtg acgcatagga agcgggggta
     2821 gatcagtgtg gcattcatgc cacggtctcc ctggcagtgc agaactcgac ccacacgtcc
     2881 ttgccttcgg ggttcgggct ggcgccccag gcgtcgaggc cgcccaggcc cgctggcgcg
     2941 cgatcagcgg cgcccacctc gtggccctgg tccgcgccgg cgcccggttc gagaacggcg
     3001 tcctggtcga gcgcgacgaa ctggcggcat gagcacgcgt ccgagtgcgg tgccccgggt
     3061 acggcgtgcc gaggggggtg aaggggggat cgggcgtcta ctccggtccc cgaggcgtac
     3121 cagaggggcc gtccagccac ccacggcgcc gccgggcttt tggacctcga ccggacgtga
     3181 aggacgcctt cacaagcgac tggcgaacgt cagcctcgcg agtctgccca gtagttggcg
     3241 agcatttccc tgggccaaac gggctcacgt acctcgccgc gcggccccat ttcctggaag
     3301 tacggagcga ggtcgtagat ggggctcccg tccaccgcat ccaggtcctc gacgtggagg
     3361 tcaaggccgt cgaccttgag cagccggggg aaggactgcg cgagctgatt ggggcgacgg
     3421 tggttgcggt gggcgaacgt gccagtcgaa ggccactggg gattgttccg ggggctgcgt
     3481 gcgtgcaaag cgacgtcgtc aggtgaggcc aagtgaaagt gccagaccac caagaggtgg
     3541 gagaactcct caaggccctg aacgacatca agagggaagt cggggttcag ccggatgatc
     3601 gctgtgccgc tccactggtc atcaaggggt tcggtgcggc caccgacgac ggtgccgatg
     3661 ggcttcatct ccaacgactt catgggcttc cccttgatct tttggccacg atgcggtcaa
     3721 tctactcggg tcaggtaaga gacggcccgc gcgtccagct ccatagcagc agggatcgca
     3781 cgatgccggt atggcgaaag cagtttgcgc atgtcgaaga ccgcttgccg ggcccttccg
     3841 gagtagatgc cctcgtccat ggcatccagg agcccgctcc aggtagcgca cgcttcctcg
     3901 acgctgccgt tgttgatctg agtggctccc aggtacccga gggtcacggc atgtgtgcgg
     3961 cggaaggcgg ctccccgggt gcggatgctc tggcgaaagt gccggatggc tcctggccgg
     4021 tcgccggagt cgcgcagggt gcaggcagtc tcgtgggcta gcgccgcgtc ggagaagaag
     4081 aacgtgcgat gaggttcggg gacgccgtcc tgtgccgagg cgaggtcatt ctcggctcgc
     4141 aacagcgcgc gtgccgcggc ccgcttctgg ccgttcgccg cgagaccacg agcgtgtaca
     4201 acgccgagca gtgaacgctc ccttggggta gctgagacgt accgttggcc ttccacggac
     4261 gccgaggaca actccaagga ttccttgaag aacccgaggt caagggcttg atgtgccatg
     4321 gcacgcagaa tgtggccgac caaaggaggg ctatccgccc gtgctgctag cttggccgcc
     4381 aggaggaagt acctttgggc aacggcgtgc tcggcgttat caaatgccat ccaggccgac
     4441 aggtaggcca gttcgccggc cgccgagaac atgtcacctc ggacctgctc gttggggaat
     4501 ttgccccgga ggagactcgc aacatccgag cgcaggtatt gcacgactgc cttacgcccg
     4561 tgccccccgc cgcgctgctg gtccatacgg gagaaggcca ccgtcagttc ttcgaccatg
     4621 gtcacgtccg cgcgccccac gtgttgttgt cgcgatggcg tcgactgcgg cggtttggcc
     4681 atcgcctgcc accactgctc tctgggcaga gcaagagcgg ccaccgagta caccgcgcca
     4741 cctatgaact tccgacggtc cgcatccaag tccattctcc ccaggtcagt cagtgagatc
     4801 agagggtcga catcccagtc gagcgttccc tgcgtcggtg tatggggact tgcgaacccg
     4861 agctgttccg gtgtgatgag gcgcttcagg cgccgggtca gcgcctggca caagataact
     4921 ggcgccgcgc cggacggtcg cgtcccgcca acccacatgg tgatgtgaga gcgcccgatg
     4981 ctcgcgtagt cgggcacctt gctctcctgg actacccgat tgaaggcgct cgcagcctgc
     5041 gcccttgacc agccggcttc ttccagtaac gcggcgagtc gctcgtttct tctgcgttct
     5101 gccatggcgg gcccctgcgc tcaaatgatc tttgaccact ttggccaagg tgggtgctct
     5161 aggcctaact ctcacctggt gagggccaac ctagtcgtag caggcgccgc aaaaggacag
     5221 acgctggagg ttccgcccct cttggctgct caactcccaa cgggctttga ccactttgac
     5281 cactcagacg cccttgaacc agttcccgtc gcgtgatgaa agcggttcgc tctacgtgtc
     5341 catcagcgtg agcgagggcg gcgacgcccc gactctgccg acaaggctgt tggcgtctag
     5401 tgcgctgagc tgcccttctg agctgcggag gtgtgaggta tggctgtcgc tgcaacgggc
     5461 gtagagatcc ttgccaagcg gagccttgga agcgtcgccg agtctctgcc gaccgtgctc
     5521 gacgacctga cgctgaccgt caaacggaca ccggttcagg atggcgcgga ttcagcggtt
     5581 gtcaccggcg tctgggtccg gcaccttcga cggatcgggg ccgccaagct caggtactgg
     5641 ggcttctcgg cgcaggtcga tgacgctgtg ctcctgatca gcgaactcgt caccaacgcc
     5701 tgtgcgccat gaggcgctct gttgtatccc cggttcaacc gggaggaact gaagggaggt
     5761 tcttgggcct gatgacttac ctggactcga aagaggaagg ggaccgcagc atgtcagaaa
     5821 atcagcgatc gtgttcaagt gtggaagcga tgcgttgagg ggcccgcgtg atatggcgaa
     5881 agctggattg cctgaacccc aatctccaaa ggatgaaatg tgtcgcatcc gccggaaacc
     5941 tgcacttgcc accggcgccg catcctgcgg tggagtaaat gcgtatccac tgcacccttc
     6001 ggatcgcggg atgattccca atgagggaat tcaaggagat gagtggggcg cctaagtcac
     6061 gctagatacg tacaacagag acgaacatgg gatcacctaa aggacgcgag tcccaaggtg
     6121 acggaggccc cgtagtagtc gcgggagtaa cgacctgcca aggaggacgg gaaagccgtc
     6181 cacagggcga agggggccag gtgactcgga catcacgatg ctgggaggta tgcgtaatgc
     6241 agagcgccga agcggtactt gatgtcctgc gtgaacgcgg caggcgtggc ctgccgtgcg
     6301 atgagctgta tcgacagctg ttcaacccga acctgtatct gctggcctac gggcgcatct
     6361 acgccaacca cggcgcaatg acccctgggg cctgcgggga gaccgcagac ggcatgtccg
     6421 aagccaagat cgggcgcatc accgaagcca tgcgccacga gcgctaccgc ttccgcccgg
     6481 tacgacgcgt tcacatcccg aaatccaacg ggaagacgcg ccccctcggc ctgccgtcct
     6541 ggtcggacaa acttgtcggc gaagtaatcc gcctcctgct ggaggcgtat tacgagccgc
     6601 ggttctccgg ccgctcccac ggtttccgtc ccggccgggg ctgccacacg gcactgtccg
     6661 aggtggcaca caaatggacc gggacaacct ggttcatcga aggagacatc tccgactgct
     6721 tcggctcgct cgaccacgag gtcctgctgg ccatcctgtc agagaagatc cgcgacaacc
     6781 ggttcctccg cctcatccaa cagatgctca aggcgggata cgtagaggac tggaaatggc
     6841 acgccactct gtcgggttcc ccgcaaggag gcgtcctctc tccgctcctg tccaacattt
     6901 atatggaccg gctggacacc ttcgtcgaga cagtactcat cccggaatac acccgaggaa
     6961 cctctcggag gaagaacccg gagtaccaga agctggaaaa cgcgatctgg aacacccggc
     7021 agcggctcgc caagagaaag gagcacaccg agtccgctca agtccgtcag tggcgcaagg
     7081 agttacgccg ccatccggtc ggggatccgc atgatcccga ctaccggcgg ctgcgctaca
     7141 tccgctacgc ggacgatcac ctcctcgggt tcaccggacc caaggccgaa gccgagacga
     7201 tcaaacagcg cctggccgcg ttcctgcgtg acgacctcaa gctggagctc aaccagagca
     7261 agacgctgat cacccacggc cgcacccagg cggcccgctt cctcggctac gacatcaccg
     7321 tccaacacgc tgacgccaag gtctcccggg gcggccgtgt caatcgcggc atgcgctcca
     7381 tcaacgggaa ggtctcgctc cgcgtgccca aggacgtgat caaggccaaa tgcgccccgt
     7441 tcgtcaagca cggcaaaccc gcgcacctgg acccactgac tggatgcaca cccttcgaca
     7501 tcatcagtct ctacggagcc cagtaccggg gcatcgtcca gtactacctg ctggccggcg
     7561 acgtgtggaa actcgaccgg ctcaaggggg tcatgctgac ctccctgctc aagactctgg
     7621 ccgccaagca ccggtcaagg gtgaccacga tggccaaccg ctacaaaacg accatcaaga
     7681 caccccaggg accacgcagg tgcttcgaag ccagaatcga acgagagggc aggaaaccac
     7741 tggtcgcacg gttcggcggc attcccctca cccggaaacg gacggccgtc ctcgacgacc
     7801 ttccgtccac catgttcacc ccgcgcagcc gaccgcgcgg cagccagctc atcgaccggc
     7861 tccaacgcgg acggtgtgaa ctctgcgaga ggcgaactga ggtgcaagta caccaaattc
     7921 gctcactggc agagctacac ggccgggaag aacgacccgc ctgggcgcta ctgatgctca
     7981 agaagcggcg cagaaccctt gtggtctgcc cgccctgtca cggaggcatc catgcgtgac
     8041 ctgggtgaga accacgcagc agtcactgga gagcccgctg caccgaaaag gtgcacggcg
     8101 ggttcgggcc ggaggccact ggaaaaggac ccgcacagcg gaaacctcgc cagtggccta
     8161 ccggtactga agcacggaaa gagccccgag gtcgcgttcc gaatggtcct cggtaccgat
     8221 cggggaaccg atcttgtggt catagaggtc gacgacggtt cgccgggccg gccgacggtc
     8281 cacgaagcgg actctgacca ggagagtggt cgcgggatgt tccttgtagc tgccaccgcg
     8341 acgtcgtggg gcgtcagcgc ggacgagacg atgacctggt gcaccttggc atcacccgcc
     8401 gtggcgagga ggggccgatg accccgagtg cgctcgcggt gctttcggcc cccggtgggg
     8461 ttcccgagag cggtagccgg ttctccaacg acgtcgggac tcagacccgt gtgcttgcga
     8521 agttgcgcga gcacgccctt gaagggtcga aggagatccc ggtgttggat gaactcttcg
     8581 aagatctcga agcggtgctg ggcgagtgcg ccgacctcgg tgaggacgac gtcgaaaggc
     8641 tgaggccgcg ggtgcatgcc tccctcaggc gggtcctcgg cgcggccgag aaggcgaacc
     8701 tcgccatacc aaccgccacc gtcaagcggg gccgggacct gctctcagac ccgcttctcg
     8761 ccgatctacg acccgtgcgt gggcacttgc gacacctcgc caccgtcacc gccgaattgc
     8821 tcgactggtt actggaggac atgccgtgac ctccagtgtt gaccttcttc ctgctgaaca
     8881 cgcctacgac ttcgactact tcagcgtcag gctggaaaac caccagcttc tccacagcag
     8941 cgttgccgtg cgcgtcttcc gagccccact acttgcggtg ccggttggtg gacgccggcg
     9001 cggcgggtac ttttccgctt ccgaggtttc gatcggcctt gcgatccgaa acgcgctggc
     9061 aggcacaccg ggctttccga acaccaagct ccgccgggct ctcttccccg attgctgcca
     9121 cgtcgtggag tggggcgaga cgccacccga taccgagagt gacgtggccc tgggccgctt
     9181 ttacggctac tccgaacgcg ccatcgccgc gcacgttcat cagaacctgt ccccaacccg
     9241 gccacgtcgc agccacattg acgcgtttgg gctgtcgcga gaccaacgag gaaagaacgg
     9301 tcgctcatga acgcgtgcga gacgcacggc ccggattcgc ggatcgatcg catctacacc
     9361 acctctgaac tgctcggcgc ggtcgtcagc gtggatgtga tcgaagtccc cgaggagatc
     9421 tcggaccacc acatcgtccg cctcacgctg gatgccgacc gtccagcgga catcctcgac
     9481 ggccaaccgg gcgtgctcca gccaaccgcg gcctgacaga cggccactcg gcgaaccggt
     9541 gttcatggcc cggctcgtcg ggcggcgatc aacccctgcc cgggaaaagc ggcttggctc
     9601 cgtccaggag tcgagcacgg cacctcgggg aggtggccaa gaaacttctt cagtcgtagt
     9661 cgcctggcta cgctccgaac gaaggtgctt ggccggcact acgagaccca acaatcctat
     9721 ggagtgaggg agttcgtatg agtcccagca tcacgcacgc cacgaaggca agcccgcagc
     9781 ccgcacaagc ggcgacggac ggcttcgagc tggacgtcac cctggtcgag gtctccgaca
     9841 ccgccggtct gatcagcctg acgaacgacg gctgcggcga gacctgcggc gcctgcacca
     9901 ccaacgtcgc ctgacctgag gcgcacgtca tcccaggccg gtgccttcgc gactcaccgc
     9961 gcgaaggcac cggccgccca cctggaccac ggaggttgtg atgacttcgc gcaccgcgtt
    10021 ccgcgccggg aagactgctc tcctccgtgc tgtcgctcgg ccggaacttc ccgtgccccc
    10081 gtgccctgac cttgatgacc cgtcccctcg cggcgcggct gcccggctcg cgtggttgcg
    10141 cgaggtgtgg ttcgaggagg acgttgccga ggctctggag cacgccagcc ccgctctcgc
    10201 ttcgcaggtg cgcgccctgt gctcgtccgg cgacccggcc gcgcgtgatg tacgacgtgc
    10261 cgtcgcctca gtagcgcgct acgtgctgcg tgccgaacac cgggcgactc cgttcggcct
    10321 gttcgccggc gtggcctcgg ctgccattgg gcccagggcg cgcacgctgt ggggctcgga
    10381 cgacacggtt gtcggccggg cgagtgcgga gtggctgact gccgtggtcg aacggctgga
    10441 gtcgtgcccc gcgctgctgg aacgtctcct ggtggtcgtc aacaacacca ccgcgaaacg
    10501 cggtgaccgg ctcatcgtgc cgtacaagtc cgacccccac ggtgatcgtc ggcgtgtggt
    10561 cgaggcatcc gtggccctga cccggcccgt gcgggcagtc ctggacgcat cacggaagcc
    10621 gatccccgcg ggtgtcctcg cggacaagct ctctgcggag ttccccgggg cgggactcgg
    10681 gaagattcaa cggctcgtac gagagctggt tcagtacgag gtattgatca cgaacttgca
    10741 cgcaccgagc acggagaccg acgctctgca acacctgctg ggccagctcg acgcggtggg
    10801 tgccggcagt gtggcgccgg tcgctgatgt ggttcgcgat ctgcacgccg tgcaggtcga
    10861 cctcagcggt tgcggttccc gcagcggccg ggcccgtgcc gccgcgcgga tgcgggctca
    10921 ggtcccaggc ttgaagcggc accccctggc tctggatctt cgtctgaacg ctcagatcga
    10981 gttgcccgaa gcggttgccc aagagatcga gcgtgccgcc agtgtcttga cccgggtgag
    11041 cgcccacccg tacgggactg cggcgtggaa ggcgtaccag cgacggttct acgagcggta
    11101 cggcatcggc acgatggtgc cgctcaacga agtcgtcgct gacagcggca ccggctttcc
    11161 cgacggatac ccgggcaccc aggccaccga ggaccgctcc cgcctctccg tacgagacga
    11221 caccttggtg cgcctggctc aggccgctgc cctcgacgga tgcgaagagg tggtgctcac
    11281 ggacgatctg atcgccgcga tggacctggg accggagcgc cccagggtgc cgccgcacct
    11341 ggaggtcggc gtccgggtgc acgcggccag tgtcgaggag ttgcaccgag ggcgcttccg
    11401 cctggagctt gcgagcgtgt cccgtggcgt tggggtcacc accggccgct tcctcagcgt
    11461 gctggctcct gaggaccgcg aggggctgtc agcggaactg gccgacctgc cgaccgcaga
    11521 cgccggcacc atcgccgccc agttgtcgtt cccgcctctg ctgtccacga gcgcccacgt
    11581 cacgcgtgct ccgcaggtgt tgcccacggt gatcagcgtc caggagcacc gcgccacaag
    11641 cagcgacgta ctcacgcccc atgacctggc ggtggcatgc gacgggcgcc gcatgtatct
    11701 ggcggcaccc gagctgggtc accgcgtcga ggcagtgggg atgcacgcgc tgaacctcac
    11761 cacgcacacc ccgccgctcg tccgcttcct caccgagctg tcccgcgccc agtgcgcgca
    11821 ggtcaccctg ttcgactggg gcgccgcgag cgcgatgccg ttcctgcccc ggctccgcta
    11881 cgggcgtaca gtgctcgccc ccgcccggtg gcggctggaa gcagccgact tgcccggccg
    11941 agaccacccc caggcccagt gggacaccgc tcttgaggag tggagggcgc ggcgacggat
    12001 gccgcagcgg gtcgtcctgg ccgaggagga ccggcgcctg cacctcgacc ttggccaggc
    12061 cggacaccgc accctgttgc gccagcatct gaaccgcgtc cgtctggcca ttttcgtgga
    12121 agctccggcc gccgacgcgt acggctggtc cgacggccgt gcgcatgagg tcgtcatgcc
    12181 gctcaaggcg acgcgaccgc cagcatggcc gcacctgccg acccccgcac cggcccgcac
    12241 tctctccccg gaacagatcc aaacccccgg agtctcttcc ctgctgctga ccaccctgta
    12301 cggcgacctg cgccgccagg acatcctgct cgcccagcat ctcccggtcc tgctggacca
    12361 gctcggcggc ccgccgtggt ggttcatccg cttccgcgac ccggatcagc acttgcgggt
    12421 gcgcatcgcc ctgccagatc ccgatgcttt tgccgagacg atccgcacaa tcggcacctg
    12481 ggccgatgaa ctgcgcggcg acagactcct gtcggacatg cgctttccca cctcctactg
    12541 tgagatgggc cgttggggct cgggggaagc ctggaacgcg gccgaggccg tgttccgcgc
    12601 cgactcgcac gccgtcgtcg cccagctcac acagtcccaa cgcccgcagc accgtgcgct
    12661 ggtggccgcg cacgccatcg ccatcgccac cgcgttcctc ggcagcactg aggaggggat
    12721 gcgctggctg atcgaacata ttccgcccac cgcgcccgca acggtgtccc gtccgcagtt
    12781 caccgaggcc gtacggctgg ccgatccctc cggcgactgg gcagctctgc gcggtgtgcc
    12841 cggcgggcac accatcgtgg aggcgtgggc cgatcggaac gaggcgctcg ccgcctaccg
    12901 gccgcacctc cccgggccgg acacccaggg catccgcctg gacgacgtcc tctcctcact
    12961 cctgcacgtg cacttcgtgc ggcacgtcgc ggtcgacttc accgaggaag agatctgcct
    13021 ctacctcaca cgcgccgccg ccctggcctg gatgtctcgg agggcacgat gacccacccc
    13081 ctcgcgctca agaccgtgga cgccgtcgcc gacctcctgg cctaccccgc caccgcaccg
    13141 atgggacccg atgcgtccct gcaccgtcag catctcgcgt acgggccgac cggcattgcc
    13201 ctgctgcaca tcgagcgggc cgccgccggc atggggccgt ggcagcgcgc ccacgaatgg
    13261 ctgaccgctg ccgctcggca gccgttcacc agcggccccg acagtcaccc cttctacggc
    13321 gcacccgccc tcgcgtacgc catggcttgc gtcgccgacc acctgcctgg cgcctaccag
    13381 cgcgctcggg gcatcctgga ccggcagatg ggtgccgaca gccgtcgccg cttggaggcc
    13441 gcgcaccgtc gcatcgacag ggggtgcctt ccggagtacg ccgagttcga cacgatccgg
    13501 gggctggcgg gctacggtgc ctacttcctg cgccgcgacc ccagcggtgc gcacgtgagc
    13561 gccatcctcg actactgcgt acgcctcacc gagccggtga cctacggcgg cgaggtcctg
    13621 ccgggatggt ggaccctcag tggaccatcc ggccgacagg acgaccgctt tccgggcggt
    13681 cacgccaacc acggcatggc ccacggcatc ggcggcgtgc tcgcgctgct ggccctcgcc
    13741 gcccgacgcg gtatcaccgt cggcggccac cgcgaagcca tccgcacaat cctggcctgg
    13801 ctggaccgtt ggcaggagaa gaccgaccga ggtgaagcgt ggctttactg ggttacgcga
    13861 gatgagctgc gcaccggccg ccccgatccg tcaccgccgc ggcgaccgtc gtggtgctac
    13921 ggaaccgccg gtctggcccg tgcccggcaa ctcgccgccc tcgccctcgg cgacacggac
    13981 cgccagatcg aagcggagaa cgcgctcgtg tccgctctca ccgatcgtgc acagctcaag
    14041 gcgaccacgg acaacggact gtgtcacgga ttctccggcc ttgcgcacat cgcggcccgg
    14101 atcgccgacg acgcgcaccc ctccaccgcc ggacagctcc gcgcggcgat accgccgctt
    14161 ctgaacgccg cctgcccgcc cggcaccgtc ccggaggaca cggcgaggtc ggtcatccag
    14221 gacgaggaag caggacccgg gttcctgaac ggcgccgccg gtatggcgct ggcgctcctg
    14281 ggccctgcca ccaccgcccc accccaatcc gcctgggata cctgcctcct catcgcctga
    14341 tccactgacc gaaggacccc accatgcccc cggaccgttg gcaccagcac aacgtcacct
    14401 tcgccgaccg cgcgagcggc aagcgcgcta tcgccgaccg cctcggcccc gccctgctcg
    14461 cggccgagga agacgggcag ctcaccggct ggtggttcat gaacaagcag ccctggccgc
    14521 tgcggtaccg atctgccgag ccgtccgcgc gggtcgagtc cttgttgagc gatcttgtcc
    14581 acggcggcac ggtcaggtcg tggttgcccg gcatctatga gccggagacc gctgccttcg
    14641 gcgggacgca ggccatggac gccgcccatg agctgttcca ccaggacagt cgccacctgc
    14701 tcacctacca gcccggcacc ggccgactgg gccgccggga gaccgccgtc ctcctgatca
    14761 gcgccatgat gcgggccgcc cgcctggact ggttcgagca gggcgacgtg tgggcgaagg
    14821 ccgccgcact ccgaccggcg ccggaggaac tgccgcccga tcgggcagcc gccctgggca
    14881 cggcgataaa gaggttgatg accgtcgaca cacgcagcct gtgccggccg accggtccgc
    14941 tcgaaggaca cgacgagtgg gtggctgcct tcgaacgggc cggtaccacg ctcgcccacc
    15001 ttgctactgg gggcgggctc acacgcggcc tgcgagccgt catcacccac cacctgatct
    15061 tccacgcaaa ccgcgcgggt ctcctcccgg atgaccaaag cgccctgttc cacctcgcac
    15121 gagaggcagt catgggatcg agcgacaaca cagcgtcgtc cgcagagggg acgcccgaaa
    15181 ccactagcgt ccgggcggtg aataccgaca cactcgccac ctctgaggct cacgcggcac
    15241 agctccgcaa caccctggtc gacaagatcc gtgaatccgg ctatgcccgc acccccgcgg
    15301 tcgagaccgc gctgcgcacc gtgccccgcc acctgttcgt gcccgaagcg acgctcgaag
    15361 acgcctacgc caatacggtg gtaaacgtca aattcgacac cgacggcacg tcgatctcct
    15421 gtgcctctca gccccaaatc gtcgcgatca tgctggacca attggacgcc cagcccggcg
    15481 aacgtatcct cgaactcggc gccggcactg gctacaacgc cgcgctactc gctcacctcg
    15541 tcggcgagac cggccacgtc accaccatcg acgtggacga cgaccttgtg gaaggggccc
    15601 gtgcgcacct ggccgccgcc gggttcacca acgtcgaggc gctgacccgc gacggagccg
    15661 tcggttacgc ggagggtgct ccgtacgacc ggatcattgc caccgtcggc gcgcacggcg
    15721 tcccccacgc ctggatgcag caactcgccc ctggtggaag gctcgtggtt ccccagcgcc
    15781 tcaagggcag cgtgtcccgc tccatcgcct acgaggagcg cgacggccga tggaccagcg
    15841 tcagcagcaa gatgaacacc ttcatgccgc tgcgaagggg tattgccgac gacgatcgcc
    15901 ccgtcatccc gctcagcgtc gacggcaccg tacggctcca gacctccgcc gggcggccca
    15961 ttgacgctgg ggccctggcc ggcgtgctgg agcagccgcg caccgaggag tggaccggga
    16021 tgatggtccg cgtcatggag tcgccggagt ggatggagct gttcgtctcc tgctccatgc
    16081 ccagcggcct gatgcggatg ctgttcccga aggacgccaa ggggacgcta ctcacggaag
    16141 acccctaccc gtcctcaact gctgttgtcg acaagggcgc tgtcacctac ctcgctcgcc
    16201 gactgtcgga gaagaagacc tcagagggcg gcaagctctg ggagttcggt gtcatcggcc
    16261 acggccctgg cagcgccgaa ctggccgcgc gggtcgcgga cgcaattcgc acctgggacc
    16321 gcgagtaccg cgatcgtgag gccacgttcg agatccagcc cctcgacgcc ccggccatcg
    16381 aacgggcccc cggcctgttc tctctcgaca ccccgctgaa ccgcatcgtc gttgactggc
    16441 ggtgatgccc gcccggctgt gaagaaggtg gtgcccgtcg cgtggccgac gggcaccacc
    16501 ggttcgccct cgctccatcc cgtcaccgtt gctccagggg gtatacgtgg acccgcacgg
    16561 cccgatagca aggcgctttc cgatcgtcgc tcggttccgg ccggcctgcc tgccgctgca
    16621 cgcccgcgta acggctctgg ttgaactggc cgcgaaggcg gtgaagcaag ccgaacaggg
    16681 cgttgcctct gccgtcttca accaggccgc gcttctcgcc tccgatatcg acctgcctga
    16741 cctcgcccgc tccatgtgcc accggcacgc cgaggcgtac ctccatgcct gccccctgcc
    16801 cgccgtgagc gccatcagag ggctggagcc cctggtcaac ctcgcgcgct tgcagatccg
    16861 cgccggccac aatgacgacg gccgccaacg actcctggac ctgtacgaag ccgtcggcgc
    16921 aggccgggcc gctgtcttcg agggcatcac cgtgccagcg aacctcaccg ccaccggcga
    16981 ggaccggcgg gaggtccatg cctggctgtg gcgcgtggtg ctcgccgacg gcacgcgcag
    17041 cctgaccacc actggccggt ggcccgaagc cctggcacac atcgagcagc accgcggcgt
    17101 gggcacgcgg atgctcgacg gccgccaagt tgccgtactc gcagccctaa ccgaggggga
    17161 cacggaccag gcagcagaac tgcttttgag cacggccccc ggtgagccgt gggagcaggc
    17221 catcaccgcc tgtctgaccg tactgtgccg ccgctacgcc ggccggcccg tagatggtca
    17281 acttacggaa ctcgtacaca tctatctcga ccgcgaagca gcatcgggct tgactgtctt
    17341 cgacattcgg ctcggcctca ctgttctcga cgcgataccg tccgccgacc atcccgctgt
    17401 ccgccgcctg gtcgacgacc tgatccgccg caccattggg gcacgtgacg ggtacgccgc
    17461 tcgcgaggtc ctggggcacc cgctgtgcgt cacgctcgcc acggagaccc agacgcggga
    17521 ctgccgagac ctggtgacgg cctgcgcgct gggggcaagg gtccttcccg aagagctcaa
    17581 cacggatctc gtgggtgcac tggacaccag ccgagcggta ctcgctcgta cagtgacggc
    17641 cccagctgac acgtctgtgc agtgacgttc aggagaatcc ggactgccgg gtagcgggac
    17701 tacggtcgaa tgcatgagtg cgtctaccga agggctgacc atgggggccg tcagcgcaat
    17761 cgtcgagagg aagatcctca ccgacaagat caggatttac cggcccggcg agccggtctt
    17821 tgacccggac acaggacagt acaagccggg tctgcccgtc accgtctacg aaggccaagg
    17881 cgccattttc cccacggggg agcgatccgc cgtcctgcac atcgccgggc aggcttacgt
    17941 ggacgacacc ccgtcccgat accggctcct gacgccactc tcggctccgg tctcctcccg
    18001 cgaggacacc gtgaccgttg tggaggctga ggacgagtcg gctatcggtc gaacctggcg
    18061 gtgatcgaca tcggtgaaac ctccacgctg aacatcgtct gcaccacatg gttggaccag
    18121 aacacccaga cgatgaaagg tgaaatgatc acgccgccgt cgtgaggcga atcagagttc
    18181 ccggaaaccg tcctacgctc gacgtatgga gatcacggac gctctgcctg ctggcaacaa
    18241 ctagcacgag agcgaaagta gccatcaacg catacatcac ggcccctgac gtggccgacg
    18301 aatccgcctg gttcaagtcc tcctacagca acgacaccgg tggttcctgc gtagagatcg
    18361 cagacctgaa cggcaaggtc ggtatccgcg actccaagga cccgcatggc ccagcctttg
    18421 tccttcccgt cggttcctgg tccaacttca tcagggcagt gacgatcggc gagttcggca
    18481 actgacgagt ccgcgaagac cgagagcgtc cctcctcaat cacagtgagg agggacgacg
    18541 ctcttcgctt caaggctcta cttgttcgaa acgggaagac gatcactgtt actggcgaga
    18601 cgactatgct cgcccggctc gcgggcacca gccgcgtcgc tgccaaagcc gtctccccct
    18661 cgtcgtcctc gtggctcgcc caggaatgaa atcagctgtt gtccgtgagg ttgaggccac
    18721 gctgcgccgc ggcagggatc gcaggccaac cggtatctac cagtgccccg tcaggccaac
    18781 cggtatctac cagtgccccg tcaggccaac gcgcatcgcg acatccaatc caggcagcaa
    18841 cggcgtgcaa cccgggggag ccgtggccac ccggacggcc ggcccgcccc cgctgcccgc
    18901 tgggccagca gagacggcca ccggcccgcc ccggaaccgc ggcccccgta cggccgcccc
    18961 cacagcacca cctcacccgt cggagtcggc ccccgtcccc cgccgccccc gcgtggcccc
    19021 ccgcaccgcc cgtaccccgc ccggcaccag gggcagtgcc agagccagcg aggcgagcag
    19081 gcagaccgcg gccgggccga ggagtgaggg gtgggggccc gtgccggtga gggtgaggcc
    19141 gaggcccgcg gtgagggtca gggcggactt ggtcactccg gatgcctcgc ccgcgcgggc
    19201 cgggtggacg acggcctggg tgccggtgag ggccaggccg cccgccacgc ccagtgcggc
    19261 cgcggctccg gtcgtggcgg ccagcagggt gggtgtggtg gtaccgggcc cggtggaccg
    19321 gagcgcggcc gcggcggtgg ccaggcagag cgccatcacc ggtacggcgg cggcgggccg
    19381 cacccggccg gcgagggggc cgccggcggc cagcgcggcg gccgggacga ggaaggcgac
    19441 ccccgccccc agcaccgaca gcccccgctc ctcctggagc gtcagcggga cggcgaacag
    19501 cagggccacg gtcgcggagt tggcgaccgc accggccgcc gtcagccgga cgtacggccg
    19561 gttgcggaag agcgcgaggt ccaccagcgg ggcccgggag cgccgctcgg cccgtacgaa
    19621 cgccgcgccc agcagtgccg cgccggccgc ccagccccag gccgcgccgt gctccaccca
    19681 ccgggagagg cagatcagcg cgccggtcgc ggcggccgcg ccggggaggt cgaggcggtg
    19741 tcccgggccc gggtcgcggg actcggccgc ccgccgggcg cacagcgcgg ccgccgcggt
    19801 gagcggcacc gtcagccaga agacggcccg ccaggagacg gcctcggcga gggcgccgcc
    19861 gaggaacggc ccgcagacgg tggccaggcc ggccagtccc agtgcccggc cggtcgcccg
    19921 gcggccgtgc cccgggggga aggaggtggt gagcagggcc agcccggcgg gcatgatcag
    19981 cgcgccgccc gcgccctgga ggatccgggc cgccaccagg aagggcagcg acggggcgag
    20041 tgcgcagagg gcggcggcgg tgccgaagaa cgccaggccg aggcggagca tccggcgcct
    20101 gccgtacaga tcgcccagcc gtccggcgac cggcatcagc gatccggcgg ccaacaggta
    20161 gccgctgatc acccaggggg cggcggtagc ggacccaggt agggcggcgc ggacgacggg
    20221 cagcgccagg ttcagcgcga aggagtccag ctggacgcag aaggcgccgg tggcgacggc
    20281 ggcgagtgcc cagcgggcgg gtgggggata cggcgctgcg gctgtacggc agggggatgc
    20341 gggcacgggg acacctctca caggtgggtg ggataagcag gggcagggcg tgtgagaggg
    20401 ggaggggtgc acgggaaggg ggccgggagg cccgggtggc tcgcgagggc ggtgtgaccg
    20461 gccggggcgc gaaaaggcgc gagggggcgc gagcgggtgc gggaaagggt gcggaagggg
    20521 gcgtgagccc gtacagcgga cgttcagcgt tcgttgatcg gagatcacca agctgaaccg
    20581 catgttgcac cgtgtgactt cagagcatgc agaaaacgcc cgtgaactgc aagaccagca
    20641 ggcgtcgcgg atcgccctca cctggaccgg agagcccggc cggatggagg agatgacgca
    20701 cggtgtactc atcgagcagg cggagcgggc cgccgccgcg ctccgccggt acggggtgcg
    20761 ggccggcgac cgggtcgcgg tgcatctgcc gctggtgccc gaatcggtga tcgccacgat
    20821 cgcctgcggg cggctggacg cgatccgcag ctcgctgccg gtctccctga ccgtgcccga
    20881 actggccgcc cgcttacggg agtcgggggc ccgggtgctg atcaccgcgg acgcggcgtt
    20941 ctgggacggg gcggtacggc cggtgaaggc gctgctcgac cacgccctgg cgcggggcgc
    21001 gggcccggac cccgtggagc ggcggacggt gctggtggtg aaccggtgcg cgcggccggt
    21061 ctcctggacg ccgggccgcg accgctggtg gcacgaggcc ctcgacgagg tctgagcggc
    21121 gggcgcgggc ggccggcgcg ggggcgggcg ccagcagcag ggagccggtg cgggcggcgg
    21181 gcaccaggag ccggcaccgg tggcgatggc cggcggcatc ggccggttct catgttttct
    21241 cgcgttaaca ggctaattag gtgccgaagg tcccgggtat ttcggtgacc tcggtcgccc
    21301 ccgcgggcgg ccaacggctc taacgcgctt cttctcggcg gagcaccgtg gaaaggcaca
    21361 ggtctctcag ccgaattagg ggaagcacca tgagtcccgc agtgaagggg tcgccgtcac
    21421 aggcggccgg tccggtcccg ccggaggagt tcgacccagg tcagtaccgg ccgggccgta
    21481 cgatcaccga ctggcagccg gagaacgagc tgttctggaa gtcggtcggc aagaaggtcg
    21541 ccaaccgcaa tctgtggatc gccgttcccg cgctgctggt ggcgttcgtg gtctggcagg
    21601 tgtggagcgt caccgccacc aacctcaagg acgtcggctt cggcttcagc acctcgcagc
    21661 tgttctggct gaccgccatc cccgggctca ccggtggcac cgcccggatc ttctacacct
    21721 tcctgggccc catcgtcggc cagcgccgct tcaccgcgct gtccacggtc gtcctgatcg
    21781 tgccgctgat ctggctcggc ttcgcggtgc agaaccccga caccccgtat gtcgtgatgg
    21841 cggccatcgc cgcgctgtgc ggtatcggcg gcgccaactt cgcctcctcg ctggccaaca
    21901 tcggcttctt cttcccgaag cgggagaagg gcaacgccac cggcatcaac ggcggtctgg
    21961 gcaacctcgg cgtctccgtc gtccagttgg tcaccccgat cgtcatcacc agctcggtgc
    22021 tggcgctggg ctccgcccag cacaaggccg acggcacgtc cgtctggctc cagaacgcgg
    22081 cgttcctgtg ggtgccggtc ctggtggcgc tggcggtggt cgcctggttc gggcagaacg
    22141 acctgaaggt cgcgtccacc ccgttcagca agcagaaggt catcttccgg cgtaagcaca
    22201 actggctgat gacctggctc tacgtcggca ccttcggctc gttcatcggc ttcgcggccg
    22261 cgctgccgat gctgatcaag acgacgttca ccccgatcga cgcggcgtac tcggcggcga
    22321 cctacgcctg gatgggcccg gcggtcggcg cgctggcccg ctgggccggc ggctggctcg
    22381 cggacaagat cggcggggcc cgggtcacca tcctgtcctt cgtgggcatg gcggtctcga
    22441 tcgtcggcgt catcaacttc ctgccgtccg gcggcgacaa cggttcgttc tggggcttct
    22501 tcggctgctt cctgagcgcg ttcctcttct ccggtatcgg caacggttcg acgttccggc
    22561 agatcccggt gatcttccgg gaccagcatc tgaagggcca ggcggagggc acccccggct
    22621 atgccgcggc gctcaagcag gccgagatgg aggcgggcgc ggtcaccggc ttcacctccg
    22681 ccatcgcggc ctacggcttc ttcttcatcc cggcgctgtt cgcctcgatc tcggtgacga
    22741 gcgcgatgtg gggcttcgtc gccttctacg tcagctgcat cgcggtggcg tggtggttct
    22801 acgcgcgcaa gggcgcggag gcgcccagct gacggcggcg ggcccgctcg gccgacgcac
    22861 acgtccgcct cctgccggcg gcggggcgac cggattcgat ccggtcgccc cgccgtcttg
    22921 cgtgcggggg tcctcgtgag gttcaggtgg tttcttcgcg gttttgcgcg accttttgga
    22981 aaattcttgt gaatgcgttc acaagtgaac cagggtcgaa agtccctcac gaaagtacag
    23041 gtcagggcgg gtgtcaagga gagatcacgg acaaggtcgg gactttcggg ctcttttcgg
    23101 ggaccaatgc cgagccgtcc gatcgatcaa atggagtcca atagaagaga cgaaggcaca
    23161 gcgattcgga aggtgtgcat catgaccgca acacccgcgg agaagacgac gagcggcgaa
    23221 gcctgggacg gtttcaaggg cggcctctgg cgggatgccg tcgacgtccg tgacttcgtc
    23281 cagcagaact acacccccta cgagggcgac agcgccttcc tcgcgggacc gacggagcgc
    23341 accaccgcgg tgtgggcgaa gctcctcggc atgttcccgc aggaactggc cgaaggcgtc
    23401 cacgacgtcg atgtgcacac cccctcgcgc atcgacgcgt tcgagccggg ctacatcgac
    23461 aaggacctcg acctcatcgt cggcctccag accgacgccc cgctcaagcg cgccatcatg
    23521 cccaacggcg gctggcggat ggtcgaaggc gccctcaacg cctacggcta cgaggccgac
    23581 ccgcaggtcc gggagatcta cacccacctg cgcaagaccc acaacgaagg cgtcttcgac
    23641 gcctacaccc ccgagatccg cgcctgccgc tcctccggca tcatcaccgg cctcccggac
    23701 gcctacggcc gcggccggat catcggcgac taccgccgca tcgccctcta cggcgtggac
    23761 cgcctcatcg aggagaagaa ggccgacaag gccgacgccg acgcgcagtg gccgaccgaa
    23821 gaggtcatcc gcgaacgcga ggagaccgcc gagcagatca aggcgctcgg cgagctcaag
    23881 gcgatggccg cccgctacgg cttcgacatc gcgcgccccg ccgccaccgg ccgcgaggcc
    23941 gtccagtggc tctacttcgg ctacctcgcc gccgtcaagg agcagaacgg cgcggccatg
    24001 tccatcggcc gcatcgacaa cttcctcgac atctacctcc agcgcgacat cgacgccggc
    24061 cgcctcaccg aggcgcaggc ccaggagtac atcgacgact tcgtcatcaa gctccgcatc
    24121 gtccgcttcc tgcgcacccc cgagtacaac gagctctact ccggcgaccc cacctgggtc
    24181 acctggtcga tggccggtat cggcgaggac ggccgcccgc tggtctcccg tacgaccttc
    24241 cgcgccctgc agaccctcta caacctcggc ccggcccccg agcccaacct caccgtcttc
    24301 tggtccccgc aactcccgca gggcttcaag gacttcgccg ccaaggtcgc catcgacacc
    24361 tcggccatcc agttcgagtc cgatgagctg atgcgcccca agtacggcga cgacaccgcc
    24421 atcgcctgct gcgtctccgc gatggccgtc ggaaagcaga tgcagttctt cggcgcccgg
    24481 gtcaacgtcg ccaaggcgct gctctacgcg atcaacggcg gccgggacga gaagaccggc
    24541 aagaccgtgg tgcagggctt cgcgcccatc gagggcgagt acctcgacta cgacaccgtc
    24601 gcgccgcagt acgacgcgat gctggagtgg ctggccaaga cgtacgtcca cgcgctcaac
    24661 gtcatccact acatgcacga caagtacgcc tacgagcgca tcgagatggc actgcacgac
    24721 cgcgccatcc tgcgcaccat ggcctgcggt atcgccgggc tctcggtcgc ggcggactcc
    24781 ctgtcggcca tcaagcacgc ccgggtgaag gtgatccgcg acgagaccgg cctggccacc
    24841 gactacgaga tcgagggcga gtacccggcg tacggcaaca acgacgaacg ggccgacgac
    24901 atcgcccgct cgctggtgca cgagttcatg cagaaggtgc gcaagcaccc gacgtaccgc
    24961 gacgcactgc acacccagtc cgtgctgacc atcacctcga acgtcgtcta cggcaagaag
    25021 accggcaaca cccccgacgg gcggcgcgcc ggcaccccct tcgcgcccgg cgccaacccg
    25081 atgaacggcc gcgacgagca cggctacatc gcctcggcga tgtcggtcgc caagctgccg
    25141 tacgacgacg ccgaggacgg catctcgctg accaacacca tcacccccga cgcgctcggc
    25201 cgcacccccc aggagcgggt cgacaacctc gccggagtgc tggacggctt catggccagc
    25261 gacggcttcc acatgaacgt caacgtgctc gacaaggcga ccctccagga cgccatggag
    25321 cacccggaga actacccgca gctgaccatc cgggtctccg gatacgcggt caacttcgtg
    25381 cggctgaccc gcgagcagca gctcgatgtc atcaaccgca ccttccacgg gtcgctctga
    25441 cccgcacccc acgggccggc cgctccggcc ggcccaccga gcccgcggcg ccggtgccgg
    25501 gccctcaccc cggcaccggc gccgcgtatc ccacagctcc acatccaccc agctctcagg
    25561 aggtcctgcc atggccgtct tgctcggctc cgacataccc gtaggcgcac ccgtcgcctg
    25621 ggatccgacg aatgagccgg tcacccccgc ggcggccgtc cagcaccgcc ccatctccgg
    25681 ctccgtgcac tcctgggacc tgtccaccgg cgtcgacggc cccggtacgc gctttgtgac
    25741 cttcctggcc ggctgcccgc tcgcctgcct gtactgccac aaccccgaca cctggaagat
    25801 gcgcaacggc aagcgcacct ccgccgacga agtggtggcc gaggccgcca agtaccgcac
    25861 cttcatccgg gccgcgggcg gcggcgccac catcagcggc ggcgaggcgc tgctccagcc
    25921 ggtcttcgcg ggggaactcc tgcaccgctt ccggcacgaa ctcggcctgc acaccgccct
    25981 ggacacctcc ggcttcctcg gcgcccgcgc caccgacgcg atgctgcgcg atgtggatct
    26041 ggtcctgctg gacatcaagt cctgggaccg cgccctctac cagcggctca ccggccggca
    26101 gctgcggccc accctggact tcgcgcaccg cctcgccgat ctcggcaccg aggtctggat
    26161 ccgcttcgtc ctcgtccccg gcctcaccga cgccccgggc aacatcgagg gcatcgccgc
    26221 cttcgccgcc tccctcggca atgtctcccg ggtggacgtc ctgccgttcc acaagctggg
    26281 cgagtccaaa tgggaccgcc tcggcatgga cttcaccctc cgcgacaccc cgtcgccgag
    26341 cccgcagcag ctggccgcgg cccgtgaggt gttcgcgggt catgggctga tggcggtctg
    26401 acggcggtct gatggcggtc tgaagggggc gacgggggct ggacg
//
