LOCUS       NZ_NDXL01000001        22095 bp    DNA     linear   CON 27-APR-2024
DEFINITION  Streptomyces kasugaensis strain BCRC 12349 scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_NDXL01000001
VERSION     NZ_NDXL01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces kasugaensis
  ORGANISM  Streptomyces kasugaensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Comparative genome analysis for kasugamycin overproduction
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Comparative genome analysis for kasugamycin overproduction
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,
            China
REFERENCE   4  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. May-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 188.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002261115.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 02:42:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,951
            CDSs (total)                      :: 7,863
            Genes (coding)                    :: 7,657
            CDSs (with protein)               :: 7,657
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 4, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 206
            CDSs (without protein)            :: 206
            Pseudo Genes (ambiguous residues) :: 0 of 206
            Pseudo Genes (frameshifted)       :: 87 of 206
            Pseudo Genes (incomplete)         :: 170 of 206
            Pseudo Genes (internal stop)      :: 23 of 206
            Pseudo Genes (multiple problems)  :: 65 of 206
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:37:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 757240
            Orig. end                         :: 779335
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NDXL01000001.1.
            Bacteria and source DNA available from BCRC.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22095
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="9"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22095
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22095
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12095](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12095)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(498..514)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.37"
                     /tool="antismash"
     misc_feature    complement(709..724)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    791..805
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     misc_feature    1446..1460
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     gene            complement(2269..3246)
                     /locus_tag="B7024_RS03000"
     CDS             complement(2269..3246)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009999170.1"
                     /locus_tag="B7024_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_094791014.1"
                     /transl_table=11
                     /translation="MRRIALTAVCAATTTVVVLGQTAANAAPTGSAPAHSAPASTVATA
                     TNQASAAKLDAYWTPQRIKNAKPLVLPKPKAVEAAERPDAKPGKPRLVPAAAPEGGPDL
                     RAKAETNTKAAAGTSVWSTVGRLVFSIPGKGDYLCTANVVNSNNHDVLATARHCVMDID
                     TGQTYTNFRFAPTYDRGNAPHGWWNWRSMGWRVDDKSAGGDNAFIVLSTGGNDGRHVQD
                     VVGGTGIGFNWDSHNYAHALGIPGDKDYAVWCEGAPYDAQQGGVSLKVCNGLSGGASGG
                     PFVVNYQPDGSAVQTASYMGSWGDAYWAYYRDAAWQVYNGAQNA"
     misc_feature    complement(3355..3372)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.15"
                     /tool="antismash"
     gene            complement(3890..4750)
                     /locus_tag="B7024_RS03005"
     CDS             complement(3890..4750)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-141). E-value: 2e-21.
                     Score: 68.7. Matches aSDomain:
                     nrpspksdomains_B7024_RS03005_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117348.1"
                     /locus_tag="B7024_RS03005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_094791015.1"
                     /sec_met_domain="PF00561 (E-value: 6.9e-19, bitscore: 66.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-13, bitscore:
                     50.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANSAEKIIEANGIDLCTQAFGNPADPAILLIHGASASMLWWEEA
                     LCERIASGGRYVIRFDNRDTGRSVSYPPGRPEYTLADMADDAIGILTAFGIDRAHLVGR
                     SMAGGIALLAAERYPDRVASLTLVSTSPGGPDLPPMSKEFTDYVDAGGPDPADPAAVVE
                     FIVGLLRIYAGGSPHYDEAGVRALAARDVARTRDLASCLTNHFVIDFGALTGLRLDEIT
                     IRTLVVHGAQDPVFPLAHGEALCRLLPQAELLIMPRTGHELPPSLWDTVVPALLHHTSQ
                     TSAPH"
     aSDomain        complement(4328..4672)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B7024_RS03005_Abhydrolase_1.1"
                     /evalue="2.00E-21"
                     /label="B7024_RS03005_Abhydrolase_1.1"
                     /locus_tag="B7024_RS03005"
                     /protein_end="141"
                     /protein_start="26"
                     /score="68.7"
                     /tool="antismash"
                     /translation="PAILLIHGASASMLWWEEALCERIASGGRYVIRFDNRDTGRSVSY
                     PPGRPEYTLADMADDAIGILTAFGIDRAHLVGRSMAGGIALLAAERYPDRVASLTLVST
                     SPGGPDLPPMS"
     gene            4954..5352
                     /locus_tag="B7024_RS03010"
     CDS             4954..5352
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140202.1"
                     /locus_tag="B7024_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_094791016.1"
                     /transl_table=11
                     /translation="MANGGEVAAGRPRCVLATVVLDCPDARALANFYRRLLGWEVRLSE
                     PDWVLLGPPEGGTGMSFQSEPDYRPPVWPERPGEQQKMLHLDIRVDDLDEAEAYAIGLG
                     ATRAGWQPQDDVRVCFDPAGHPFYLFVP"
     gene            6127..6834
                     /locus_tag="B7024_RS03015"
     CDS             6127..6834
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS03015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_052853994.1"
                     /transl_table=11
                     /translation="MSWKNTATTDTAATGTTTARSSLRRGRRIAAASLIAVAALSLTAC
                     QNDRDGVKASPDASSPGTPGQAPSDGAPATPAKNGSDGGGKSPESGQSHGSGAGATGGG
                     SGARHSGASGSGAGAGSSNGGGSTNGGGSASRGKGVVGTWEGVLNYLAPGKLTVTPSSG
                     PEQAFFIGPQTKTLGAAGICASNGNVTVDSHGYGTSPCTEAQLEKASKMDAIRVRVTVR
                     DGLATEIAERYHP"
     gene            complement(6916..8796)
                     /locus_tag="B7024_RS03020"
     CDS             complement(6916..8796)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174697.1"
                     /locus_tag="B7024_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_094791017.1"
                     /transl_table=11
                     /translation="MRRGTALAAPRTKAATVLLAVLTLLFGALALPGTAHADLQHPRQE
                     FLRGSVSGLFLHWGERTAPQHTSCAGWEKDVTDGGWNPDYWVKEAGKLHAQYLVLATFH
                     SRLGYARPWPSDIPGSCNTRRDFLGELITAAKARGLKVMLYMTDDPQWHDQGGHEWLDS
                     AGYSRHKGRDIDLTTREGFGEFSYDNFFEVMDRYPQLGGFWIDNDNDYWLTHHLYEQIY
                     SKRPDYTLSNNNEDTPIMDMISNEQKTGMSPAYDYPQAIYTAAPRLTEADFKLPATGAW
                     WYDGSDPDVDRKLTLGRLVTNAGSSIKALMAETAQVNGRFPAKQEAFNTFADGYLDAIW
                     ESLHGTEGGGYLHGGLAPGYWNDGAHGVTTVSATDPDRHYLHVITPPSKPTLRLRDNGY
                     RVAEVTNLRTGARIPFTQSGGYLTLTGLGDWDPYDTVFKVRTVGRQGILPASSYTMSAG
                     AAASGHPAAAAADGDYLTYWDNDRTLPVSLDYDLGAARKVRYLGLNQREDSVSYARSDT
                     EQSARIKDYRVYASQDGKHWGSPVASGTLPSRRGVSFIDLPATTTRHLRLEVLSTHAAA
                     TDTKRYRRLRIDESWLGTAYATPAAIRAAATAPVPKPISSPGGRPGRPAS"
     gene            complement(8802..10004)
                     /locus_tag="B7024_RS03025"
     CDS             complement(8802..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119200.1"
                     /locus_tag="B7024_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_094791018.1"
                     /transl_table=11
                     /translation="MNARFRGALTAALLACAALVLPGPPAAAAHPEPGTPARQAATTRP
                     GAATDWSVALTDSTLARYTPATIGGWSYPVGLYLYGQYLVYLRTHQQRYLDYLKEYVDR
                     FVDDAGNIGQGFNSLDSMQAGRLLVILHHETGADRYRIAAHKIRKRLDSYPRTADGGFW
                     HATTSSRAHQLWGDGVYMVTPFLVEYGREFGDTQYADDEAARQLDVYGTHLQSPNGLLR
                     HAYDESGTAGWADPKTGQAPEQWCRAVGWYAMADVDVLDALPAGHPRRARLTGILRKLA
                     AGLERTQDPATGRWFQVMDKGDRPGNWTETSCTSMFAFALSRGVQQGYLDPHYTKVAQR
                     AYTGVLQNISLGGDGRTDLTGITVGTNVGDYAYYIDRTRATNDFHGLGAFLIMSEQLRA
                     R"
     gene            complement(10001..11167)
                     /gene="pqqE"
                     /locus_tag="B7024_RS03030"
     CDS             complement(10001..11167)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="B7024_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_094791019.1"
                     /sec_met_domain="PF04055 (E-value: 1.6e-25, bitscore: 88.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.5e-06, bitscore: 25.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.8e-07, bitscore: 27.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.7e-08, bitscore:
                     32.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPGERPPEPAAPPGAPLPPRPWALLAELTHGCPLHCPYCSNPL
                     ELTRRSAELTTEQWVDALRQAAGLGVVSAHLSGGEPLLRSDLAEIVAAADGAGIHTQLV
                     TSGVGLGRDRLGRLADAGLRSVQLSVQHADPGANDRIAGRRSFAAKERAAALVRDSGLP
                     LGLNVVLHRHNLDALDELIDLATAWGADRIELANTQFYGWALRNRAELLPSREQLARAE
                     RTVRRRRAELAGRTELVWVVPDYFDGKAKPCMGGWGAVSLTITPDGTTLPCPAAAVLPG
                     LDAPNVRDRPLAWIWDHSPAFTRYRGTEWMREPCRGCALREQDFGGCRCQAFALTGDAA
                     ATDPACRLSPDHALVRDLVTASPEGAPAGLGRPRKPARRAPAAPKGAR"
     gene            complement(11164..11421)
                     /gene="pqqD"
                     /locus_tag="B7024_RS03035"
     CDS             complement(11164..11421)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433952.1"
                     /locus_tag="B7024_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_244933812.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.2e-19, bitscore:
                     66.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.5e-10, bitscore: 37.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRWCPALAPAVQLRHDRVRDTDLLLLPERVVVLEGSAGAVLRLC
                     DGVRAVPDIVAELAVRYPDAPVAAEVPAFLGRIRAEGWLR"
     aSDomain        complement(11170..11409)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7024_RS03035_PqqD_RRE.1"
                     /evalue="2.10E-21"
                     /identifier="RREFam006.1"
                     /label="B7024_RS03035"
                     /locus_tag="B7024_RS03035"
                     /protein_end="84"
                     /protein_start="4"
                     /score="66.5"
                     /tool="antismash"
                     /translation="CPALAPAVQLRHDRVRDTDLLLLPERVVVLEGSAGAVLRLCDGVR
                     AVPDIVAELAVRYPDAPVAAEVPAFLGRIRAEGWL"
     gene            complement(11418..12095)
                     /gene="pqqC"
                     /locus_tag="B7024_RS03040"
     CDS             complement(11418..12095)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="B7024_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_094791021.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.3e-82, bitscore:
                     273.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPFEERLRTVARDSYHDRHPFNLRMHAGELTPDELRRWIRNRF
                     HYQRCIPVKDALITAKLGTPELRRMWLRRIQDHDGQREGEGGLERWLRLGEAAGLDRAL
                     LLDEAGVLPGVRLAVDGYVNFCRLRTPLEAVAASLTELSAPDIMRTRIDAFERHYGWID
                     EEGLAYFRGRQAQGRRDSKEALALVLDWARTDAEQDLAVAALTFKCQVLWSLLDAVERG
                     ERP"
     gene            complement(12092..13006)
                     /gene="pqqB"
                     /locus_tag="B7024_RS03045"
     CDS             complement(12092..13006)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="B7024_RS03045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_094791022.1"
                     /transl_table=11
                     /translation="MLLRVLGTAAGGGVPQWNCACPGCTGARDHPDRRRRHASLAVRAD
                     DDHWYLINATPDIADQIESTADLHPGPAARRTPVAGVVLTDAELDHTLGIARLREADRI
                     EILATGRVRTALCEQAHLDAVLTPYADLVWRELGARPVPLREGSDVEISAVPVSAKRPR
                     YAAAAPGPAGPDAGPEPWVVALRLHDRRTGGTAVYAPALAAWSDAFQDALADADCVLVD
                     GTFWDDDEPRRSGFSTRTATGMGHLPIDGPAGTARRLAPLAARCLYTHLNNTNPLVDPG
                     APQHERLAEQGLAVAAEGMEIAL"
     gene            complement(13017..13175)
                     /gene="pqqA"
                     /locus_tag="B7024_RS39820"
     CDS             complement(13017..13175)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094221484.1"
                     /locus_tag="B7024_RS39820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_172450415.1"
                     /transl_table=11
                     /translation="MNDAMEQPPRNSQPPHTPGPAAPHGERTAWQAPDYTVIETALEVT
                     AYSLNAR"
     misc_feature    complement(13480..13489)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     gene            13793..14968
                     /locus_tag="B7024_RS03055"
     CDS             13793..14968
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="B7024_RS03055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_094793010.1"
                     /transl_table=11
                     /translation="MRTTTARHASLTAVAAATLATGLLIAAAGTGGAATAPHSAATTTT
                     NSATGGATATGRAAAAATAPGLTSAPGSIKTISSDWSIPWGLSWLPDGSALITERDTFK
                     VFTLAQDGTKKEIGKVPNVVTTGGEGGLLSIAVSPSWKTDHYVYLMHTASEGNRIARMT
                     FNGGKLSGYKVLVDGIKKNKYHDGGRLKFGPDGYLYATTGEAQDRKLAQDKSSLNGKIL
                     RMTTDGKPAPGNPFGTLLYSYGHRNPQGITWDAQGRLWEAEFGDAKYDELNLIEPGKNY
                     GWPTCEGTCSVDGMTNPKRQWPVSEASPSAVAYADGAIYMAALRGQRLWRIPVDGTTAG
                     TPKAYYTGDYGRLRTVETVPGKNSLWLTTTNADNNGKAGPGSDKVFQVDLK"
     gene            15427..16155
                     /locus_tag="B7024_RS03060"
     CDS             15427..16155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606899.1"
                     /locus_tag="B7024_RS03060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_094791023.1"
                     /transl_table=11
                     /translation="MGSAPPGEALGENSGAGSGGRGAPAAVGHAPGRRQLAPGAVHVPG
                     WLTLAQQRELVAACRGWARGPVPIRHTRLPRGGTMSVQTVCIGWHWQPYAYTRTADDVN
                     GARVAAFPDWMVGLGRRAVAEAYEDAAAGDGYTPDTALINFYDGQARLGMHQDKEERSD
                     APVVSLSIGDTCVFRFGNTRTRTKPYTDVELASGDLFVFGGPSRFAYHGVPKVRPGSGD
                     PACGLAGGRLNITMRVTGLG"
     gene            16241..16465
                     /locus_tag="B7024_RS03065"
     CDS             16241..16465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608263.1"
                     /locus_tag="B7024_RS03065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2277 domain-containing protein"
                     /protein_id="WP_094791024.1"
                     /transl_table=11
                     /translation="MCRSIKTLRPPVTPEVTEEDIRAAAVQYVRKVSGFRAPAAHNREV
                     FDHAVESVAAATRELLDGLRVRGSTATRT"
     gene            complement(16489..17310)
                     /locus_tag="B7024_RS03070"
     CDS             complement(16489..17310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058163.1"
                     /locus_tag="B7024_RS03070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_244934036.1"
                     /transl_table=11
                     /translation="MAAYGAGPASAADRGPGLRVMTFNLRYASDTPPHSWAERRPVMRA
                     LLRREAPHLLGTQEGLYGQLRDIAADLGPRYAWVGTGRGGGSRDEFVAVFYDVHRLVPV
                     EYDHFWLSATPLLIGSATWGNTVVRMVTWVRFRDLHAGGEFYALNTHLDHAHQYARERS
                     AALITERLAALDPALPRIVTGDFNVAAHRNPVYDAMLGGGTLVDSWDTAARRSAQYGTF
                     HGYRPLVPDGDRVDWILTSPGVRTRRATINTFAEHGRFPSDHLPVQALLDR"
     misc_feature    17482..17497
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(17572..18189)
                     /locus_tag="B7024_RS03075"
     CDS             complement(17572..18189)
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574713.1"
                     /locus_tag="B7024_RS03075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavin reductase family protein"
                     /protein_id="WP_094791025.1"
                     /transl_table=11
                     /translation="MRTDFDPAVLPRNEFYRLLTAVVVPRPIAWVSTIGPDGVANLAPH
                     SFFTIASVAPPVVQFTSVGRKDSLRNIEATGEFVVNLAPEGMFEQINDSAVDFPHRTSE
                     FEAAGITAEPSLRVEPPRVAASPVALECEAYSTLGIGDSTIVFGRVVHAAVAQDVLMDG
                     HPEITRLRPLSRLGKNEWGTLGEVREMARIRYADWQGPAGGR"
     misc_feature    18187..18202
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(18328..19539)
                     /locus_tag="B7024_RS03080"
     CDS             complement(18328..19539)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577849.1"
                     /locus_tag="B7024_RS03080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_094791026.1"
                     /transl_table=11
                     /translation="MSTPSILISGASIAGPTLASWLGAAGWDVTVIERFDQLRDEGQNI
                     DIRGTGREVLRRMGLEDVVRAAHTHETGLDFVDERGRPVARIAAGTDDTSGGTAELEIL
                     RGRLSRILHDHSSTDAAYVFGDQITALHDDGHGVDVEFRHGPARRFDAVVIAEGLRSRT
                     RSLVIRDVRLRELGLYSAYFTIPRTDADNNRWRWLIADRGRGVTLRPDDVGTIRASLNM
                     HSATRGLDRLDRADIVTILRATFADIGWETPRILDALDDSPLYFESLGQARLPRWSSGR
                     IALLGDTAYCASPVSGMGTTLAVTGAYVLAGELTRHTDPQAAFARYEAVMRPFAERAQQ
                     LRPGFPYMFYPRTRLQRSLVWAGLRAAASPLANRLVGGAGALFSPPAEALDLPDHAMAS
                     RNGG"
     gene            complement(19793..20857)
                     /locus_tag="B7024_RS03085"
     CDS             complement(19793..20857)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS03085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094791027.1"
                     /transl_table=11
                     /translation="MSTSFPVGAELAVLSQSGHTLSFFDLASGRRSDIVPVLPEGHELC
                     FDPVRRRLYASHTYRSGHFAAHDEKGHEVSVIDVDTHQVVEVIDLAPEHGPHALALDAA
                     ADLLYVSVEEGPAGPGGLVAIDLRTNEVVARYSADAPVPHWAVLAPDGTAAYTTNKSAL
                     FASRIDLTGRTPVRRIPVPGSEGLALSPAGDRLYIATPTALSPPDPTAPHAVKVIDTTT
                     LTTLAAIALPATPGPVHVTGTGKLLVGCWPLSGSRANPFADGILSILDAETYRYLGELN
                     VGITPINIISAAEGHLAFVSHLIAGTVTVVDLDAHTPVTTLEVDLGDPGGEFSKNTHNQ
                     GAHGLVYIPPRAGV"
     misc_feature    complement(21046..21056)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(21534..21938)
                     /locus_tag="B7024_RS03090"
     CDS             complement(21534..21938)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982147.1"
                     /locus_tag="B7024_RS03090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_052854017.1"
                     /transl_table=11
                     /translation="MTPTPTATSAAPPTWVLQIMHEIDTLAFGEGFARMTDETEMYFGT
                     AHVVGVEAIKAFFVKIDEPLDITHEVVEYWTAAQGVHILRGEATMAKKTAPDAVVRAPF
                     MHIYRLDGAEPARIRTLHITAGPLRTDSVI"
ORIGIN
        1 cgcggatttt gggtactttc acagagtccg accaataaga catagtggac acatgcgggc
       61 attcccccgc tcgtcttgac cggtcgagtg gatgagcccg agccaaccga atccacatac
      121 atcgacacta cctccacccc atccagagag acgtccggaa gaaggcatcc gccaaccgct
      181 cacgccatcg gctacccagt agcgacaggg cctccgaact cggctctgat cagcagagca
      241 cctgaaggtt gctgtcgcgg cgatcgatcg catcgccggt gtgatcgatg ccaagagcag
      301 tggtcccaga gcagcgtccg ccgtcgcccg cgatgacgat gacactgacg gcccgtctcc
      361 ggcgaggatg cgctgcctaa tcacgcttca gccggagggg agttgggcgt gccggtcgct
      421 tctactccat gccatgccag ccccctgggc cgacctcgga ttccgattcc ggcttcatct
      481 gcgaacttaa gtgattattc gaatgaaatt tcaatcgaac ggaattaccc ggctattcgg
      541 gtgatatatc aaaagagcga cgggtagagc atcttcgtcc catcacaacg cgcaaggaga
      601 caaagatgcg caagctcgta ggacgtgccg tcgcttcggc agttctcgca acggctgctc
      661 tcgtccccct gtccggcatc gcggcagccg ccgctccgac tcacacgccc gtccagacgg
      721 tcacccgggc cgcggactcc gaccgggggc accacggttg gggtcaccat ggctgggggc
      781 accatggctg ggatggctac ggccaccggt ggcaccacgg catcggcttg ggtcttggac
      841 ttggcttggg cctggttctc tgaccgcgat ccgaacagct gcggtgcgac gcgcgtgagc
      901 gctcagcgac tgcacggcta gctgtcgact gacccacgtc tggggccggc gccgttccac
      961 cgccaggctc cgcctctggg taggacgaag gtcccgatca acctggtcgg gaccttcgtt
     1021 gtgtcggtga tcagcgatac gcccgcacgc cgaagacacc ccgagtgcta cgtctgcaca
     1081 tgtgaggtca agcagccgtt gccggttctg gagttcggca atggctacga gcaaccggcc
     1141 ggcgcggttg tggccatgac cgcggacgtt gccggtcagt ttgcgtcggt ggcgccgtac
     1201 gcggacggtg ccgggacagg cgccggtggc ggcgtggacg gtatggatgt caactgctcc
     1261 cggccgacag aagagcgtga cgccggggcg gatctcatcg cctcccgagg tcgcaccagc
     1321 tcagagcttg agcattcagt tctgcggtat gggacggcga acaccacttc tcatgggggt
     1381 tggggtggcg gaggcttcgt cgacgtactc gcgcagcaac tcggcgagac caccgtaagc
     1441 gcgacaggcc gtccagccct gcgagggtat cggccggccg ccgacaggtg cgttcagtcc
     1501 ccgctgctct gctcggtgcg gatcgtgtgt ccgtgtggtc tcagtccctg cacctccctc
     1561 catccaaggt ggtcgatgta gggaaagcga gaaacttcag caccgtctca cggactgctt
     1621 gccccttctg cccggccggt gcggcaccct tgctcgatga cccaggcatc cttggtgcac
     1681 tcctcaacga tccgccactt gaccccaaaa cctcatgtag cacgcccgtc ggatcgtggc
     1741 ggactttgcg gccccgatcc ccatcgcacc cagcagtggc gacgcggccg agggtgcccc
     1801 acgtgtacgt gcgtggggag cacttgagcc gggagctgca tgcactccgc gtgccgggag
     1861 catccccgcc cacgcgggga ccacatgtcc gtgaggaccg cgttcggcac cgtgccggga
     1921 gcatccccgc ccacgcgggg accacaaggc gcgacctgcg gattcaccac cggccgacgc
     1981 gattttcagg cgctttcacg gaatccggcg aacaggacat agcggataca tccgcacccc
     2041 ctccgcccat cctggccacc agagcgggta cacccaagcc aacccgccaa ccatccaacc
     2101 cgccaccccg aaacgccccc accgacccta tccccggccc agccaggtcg cagtacaggt
     2161 cccgaaatca acgccgcccc gacctcagca caggaatagc cactaccagc gacggggcgc
     2221 agccgtcccg ctgcgccccg tcgccgcaag cacagttgca gcagtgcgtc aggcgttctg
     2281 ggcgccgttg tagacctgcc aggccgcgtc gcggtagtag gcccagtagg cgtcgcccca
     2341 ggagcccatg tagctggcgg tctgtacggc cgagccgtcg ggctggtagt tcacgacgaa
     2401 cgggccgccg ctggcgccgc ccgagaggcc gttgcagacc ttgaggctca cgccgccctg
     2461 ctgggcgtcg tagggtgcgc cttcgcacca gacggcgtag tccttgtcgc cggggatgcc
     2521 gagggcgtgg gcgtagttgt gggagtccca gttgaagccg atgcccgtgc cgccgaccac
     2581 gtcctggacg tgccggccgt cgttgccgcc cgtgctcagc acgatgaagg cgttgtcgcc
     2641 gccggcggac ttgtcgtcca cgcgccagcc catggaacgc cagttccacc agccgtgggg
     2701 cgcgttgccg cggtcgtagg tgggtgcgaa gcggaagttg gtgtaggtct ggccggtgtc
     2761 gatgtccatg acgcagtgcc gggccgtggc gagcacgtcg tggttgttgc tgttgacgac
     2821 gttggcggtg cagaggtagt cgcccttgcc ggggatgctg aagaccagcc gtccgacggt
     2881 ggaccagacg ctggtgcccg cggcggcctt ggtgttggtc tcggccttgg cgcgcaggtc
     2941 cggcccgccc tcgggagcgg cggcggggac gagtctgggc ttgcccggct tggcgtcggg
     3001 tctctcggcg gcctcgacgg ccttcggctt gggcaggacg agcggcttgg cgttcttgat
     3061 gcgctgcggc gtccagtagg cgtcgagctt cgcggccgac gcctggttgg tggcggtggc
     3121 gaccgtcgag gccggggcgg agtgggctgg agcagagcct gtcggggccg cgttggcggc
     3181 ggtctggccg aggacaacca ccgtcgtggt ggccgcgcag acggcggtca gtgctattcg
     3241 tcgcatgagc ttccctgctt tccatacgga aggggatgaa gcgaaaggga gatacaagcg
     3301 gaagggagat gcactggaac gccgtgagta tgggcagagt cattcaactt ccgataaacg
     3361 agcgatcaac atcgtgaacc gcccacgcct ggttaccggt tcgggcgggg actgactctt
     3421 gatcaccgcc gctgcttgga atccgtacga ggcggccgca tcgagagtga cgcctgcagc
     3481 cgaagtgccg cgatccaagg cggtgttgat gccaagggaa gcacctgaag gggcgcaacg
     3541 ggctcgtgcg ggatcggcgg ccgtccggta ctcatcagtg gagcaggcaa gtcgtcgacc
     3601 acgggcctgc ccctgaaccc gtgcgcacag cggcacctgc ccctcacccg atccgctcag
     3661 ccgaacaaac caagccgccg gcccgccggt agtccgaccc accggtggta cgacgccctc
     3721 acacagatcg tcaccacccc gcagccgaca accgagacgt agggagggag agggaacgag
     3781 cgagccccgc ccccgtgcgc tgtcacgggg gcggggccgg gtccgagtag cgccagcagc
     3841 tcggatggtg acgggaacca cggtacgggc gaccactgac aacggcgggt cagtgcgggg
     3901 cggaggtctg ggacgtgtgg tggaggaggg ccggtacaac ggtgtcccag agggatggcg
     3961 ggagctcgtg gccggttctg ggcatgatca gcagttcggc ttgcgggagg aggcggcaca
     4021 gggcttcgcc gtgggcgagc gggaagacgg ggtcctgtgc gccgtgcacc accagtgtgc
     4081 ggatggtgat ctcgtccagg cggaggccgg tcagggcgcc gaagtcgatg acgaagtggt
     4141 tggtcagaca cgaggcgaga tcgcgcgtcc gggcgacgtc gcgggcggcc agggcccgca
     4201 caccggcctc gtcgtagtgc ggtgagccgc ccgcgtagat ccgcagcagg ccgacgatga
     4261 actccaccac ggccgcgggg tccgcggggt ccgggccgcc ggcatcgacg tagtcggtga
     4321 actccttcga catcggtggc aggtccgggc cgcccggact ggtggagacc agggtcaggg
     4381 acgccacccg gtcggggtac cgctccgcgg ccagcagcgc gatcccaccg gccatcgacc
     4441 gccccacgag atgcgcgcgg tcgataccga aggcggtcag gatgccgatc gcgtcgtccg
     4501 ccatatcggc cagcgtgtac tccggccggc ccggcgggta gctgaccgat ctgccggtgt
     4561 cccggttgtc gaagcggatg acgtaccggc cgccggacgc gatccgttcg cagagtgcct
     4621 cctcccacca cagcatcgag gccgacgcac cgtggatgag caggatcgcc ggatccgccg
     4681 gattgccgaa tgcctgcgtg cagaggtcga tgccgttggc ctcgatgatc ttctcggcgc
     4741 tgttcgccat gcgtacgctc cttctctggt ggggaccagc ctgcccggac ggcgtggctg
     4801 cggcgtccgg cgcgccggag ggtggggtgt gtcgcggcgg cgcgtcgcga acgaggcggt
     4861 gcgacgcagc gaacggtggg gcggcatggc gtgggaggga acgagcccgg cggtccgtcc
     4921 gggtgagggc gaggggaagg gcggcgaggg ctgatggcga acggtggcga ggtggcggcc
     4981 ggcaggccgc ggtgcgtgct ggcgacggtg gtcttggatt gtccggacgc gcgggcgctc
     5041 gcgaacttct accggcgact gctggggtgg gaggtgagac tgagcgagcc ggactgggtg
     5101 ctgctcgggc cgccggaggg cggcacgggg atgtcgttcc agtccgagcc ggactatcgg
     5161 cccccggtgt ggccggaacg gcccggggag cagcagaaga tgctgcatct cgacatccgt
     5221 gtcgacgatc tcgacgaggc cgaggcgtac gcgatcgggc tgggtgcgac gcgggccgga
     5281 tggcagccgc aggacgacgt acgcgtctgt ttcgaccccg cgggacatcc gttctacctc
     5341 ttcgtcccgt gatcgctcgc gctccgcgtc cggtgaccat tcaacggcgg cgcatggccg
     5401 aacgcggagc gtgtgggact gaacacatga aggcagggca accggaccga atgcccgatg
     5461 atctccgcag gtcagagagg tgagaaggcg tcagggccgc aacgggggta cgtgtccgag
     5521 gcgttcggcc ggcgcacggg acggtgcatt gtcagtggct gcccctagca tgtctcacat
     5581 gtccccaact ccttctgccc ctacaactac ggccgttccg gcctccgaag cgaacgaatc
     5641 gatccggcgt tttgtgcgca cccggcgcgg tgcggcgtgg acggcgcagg acatggcgga
     5701 gtacgcggtg ctgctggagg tctggacgca cgcggcgcgt aagccggtcg tcgaggcggc
     5761 gtaacgcgcc acggcgatgc ccggtcaggc gatgggcaga caggcgacac ccggacagac
     5821 gatggtcgtg gcggtgtgcg ggtcccccga cggaaccggg gtcgggaggg gcaggatcgt
     5881 ggccggcccg cagactccgc cggacagggc ggtgggccga gagcagtcgg ccaggtcctt
     5941 ctcccagggc ggcgcccggc gaccgcgtta gccggacgtt agggagcgac cggccgggcg
     6001 ttagtggatc aacagtggct ccgtccagac tgatgcatgt acacagcacg gagatggccg
     6061 ggaagacacc gaatctccga gagccaccga accaccatgc agtcgcctgc gcgcaagggg
     6121 gatcccatgt cctggaagaa caccgccacc actgacaccg ccgccaccgg caccaccacc
     6181 gcccgctcgt cgctccggcg ggggcgccgg atcgccgccg cttcgctgat cgccgtcgcc
     6241 gcgctgtcgc tgaccgcctg ccagaacgac cgggacggcg tcaaggcgag cccggacgcg
     6301 tccagccccg gcactcctgg tcaggcgccg tccgacggag ctccggccac accggccaag
     6361 aacgggtccg acggcggcgg caagtcgccg gaaagcgggc agagccacgg gagcggagcg
     6421 ggcgccaccg gcggcggcag tggtgcccgg cactccggag cgagcggatc cggtgccggg
     6481 gcggggtcct cgaacggtgg cgggtccacg aacggtggcg gctctgcgtc ccgaggcaag
     6541 ggagtggtcg gcacctggga gggcgtcctc aactacctgg cgccgggcaa gctgacggtc
     6601 accccgtcgt ccggccccga gcaggcgttc ttcatcgggc cacagaccaa gaccctgggc
     6661 gccgccggga tctgcgcctc caacggcaac gtcaccgtgg acagccacgg ctacggcacc
     6721 tcgccgtgca ccgaggccca gttggagaag gcgtccaaga tggacgctat ccgggtccgg
     6781 gtgacggtcc gggatggtct cgccaccgag atcgcggagc gctaccaccc ctgaggacac
     6841 accccgggcg ggccgttgcg gcccgcccgg tcggctgccg tcgcggaaac ccccgtccgc
     6901 ggcggcagcg tcatctcagg atgccgggcg gcccggtcgg ccacccgggg acgaaatggg
     6961 tttcggtacc ggggccgttg ccgctgcccg gattgccgcc ggggtcgcgt aggcggtccc
     7021 gagccagctc tcgtcgatgc gcagccgccg gtagcgcttg gtgtcggtgg cggccgcgtg
     7081 ggtgctgagg acttccagtc gcaggtggcg ggtggtggtc gcgggaaggt cgatgaagga
     7141 gacgccgcgc cggctcggga gcgtgccgct cgccacggga ctcccccagt gcttgccgtc
     7201 ctggctggcg tacacccggt agtccttgat ccgcgcagac tgctcggtgt ccgagcgggc
     7261 gtaactgacc gagtcctccc gctggttgag gccgaggtag cgcaccttcc gggcggcgcc
     7321 gaggtcgtag tccagggaga ccggcagggt gcggtcgttg tcccagtacg tcagatagtc
     7381 gccgtccgcg gccgccgcgg cggggtgtcc gctcgccgcg gcgccggcgc tcatcgtgta
     7441 tgaggaggcg ggcaggatgc cctggcgtcc cacggtacgg accttgaaaa cggtgtcgta
     7501 cggatcccag tcgccgaggc cggtcagggt gaggtagccg ccggactggg tgaaggggat
     7561 ccgcgcgccg gtccgcaggt tggtcacctc ggccacccgg tatccgttgt cgcgcagccg
     7621 gagggtgggc ttcgacggcg gggtgatgac gtggaggtag tggcggtcgg ggtcggtggc
     7681 gctgacggtg gtgacgccgt gcgcgccgtc gttccagtag ccgggcgcga ggccgccgtg
     7741 gaggtaaccg ccgccttcgg tgccgtgcag ggactcccag atggcgtcga gataaccgtc
     7801 ggcgaaggtg ttgaaggctt cctgcttggc cgggaaacgg ccgttgacct gcgcggtctc
     7861 ggccatcagg gctttgatcg aggaaccggc gttggtgacc aggcggccca gggtgagctt
     7921 gcggtcgacg tccggatcgg atccgtcgta ccaccaggcc ccggtggcgg ggagtttgaa
     7981 gtccgcctcg gtcagccggg gtgcggcggt gtagatggcc tgcggatagt cgtaggccgg
     8041 ggacatgccg gtcttctgct cattgctgat catgtccatg atcggcgtgt cctcgttgtt
     8101 gttgctgagg gtgtagtccg ggcgcttgct gtagatctgc tcgtagaggt ggtgggtcag
     8161 ccagtagtcg ttgtcgttgt cgatccagaa accgcccagc tgggggtagc ggtccatgac
     8221 ctcgaagaag ttgtcgtagg agaactcgcc gaagccctcc cgggtggtga ggtcgatatc
     8281 gcggcccttg tggcgggagt agccggccga gtccagccat tcatggccgc cctggtcgtg
     8341 ccactgcggg tcgtcggtca tatagagcat gaccttcaga ccgcgggcct tggccgccgt
     8401 gatcagctcg ccgaggaagt cccgccgggt gttgcagctc cccgggatgt ccgacggcca
     8461 gggcctggcg taaccgagcc ggctgtggaa ggtcgccagc accaggtact gagcgtgcag
     8521 tttgccggcc tctttcaccc agtagtccgg attccatccg ccgtcggtga cgtccttctc
     8581 ccagccggcg cagctggtgt gctgcggcgc ggtccgctcc ccccagtgga ggaagagccc
     8641 ggagaccgaa ccgcgcagga actcctgacg cgggtgctgg agatcggcgt gtgccgtgcc
     8701 gggcagcgcg agcgcgccga acagcagggt cagtacggcc aggagcaccg tggccgcctt
     8761 ggtacgcgga gccgcgaggg ccgtccctcg tctcatgtgc gtcacctcgc ccgcagttgt
     8821 tccgacatga tcaggaaggc gcccagaccg tggaagtcgt tggtggcccg ggtgcggtcg
     8881 atgtagtagg cgtagtcgcc aacattggtg ccgacggtga taccggtgag gtcggtgcgc
     8941 ccgtcaccgc cgagcgagat gttttgcagc acgcccgtgt acgcccgctg ggcgaccttc
     9001 gtgtagtgcg ggtccagata gccctgctgc accccacggg agagcgcgaa ggcgaacatg
     9061 ctcgtacagg aggtctcggt ccagttgccg gggcggtccc ccttgtccat gacctggaac
     9121 cagcggccgg tggccgggtc ctgggtgcgt tccaggcccg ccgcgagctt gcgcaggatg
     9181 ccggtgagcc gggcgcggcg cggatggccg gcgggcagtg cgtccagcac gtcgacatcg
     9241 gccatggcgt accagccgac ggcgcggcac cactgttcgg gcgcctgtcc ggtcttcggg
     9301 tcggcccagc cggcggtccc ggactcgtcg taggcgtggc gcagcaggcc attcgggctc
     9361 tgcaaatgcg tgccgtagac gtcgagttgg cgggccgcct cgtcgtcggc gtactgcgtg
     9421 tcgccgaatt ccctgccgta ttcgacgagg aagggggtga ccatgtagac cccgtcgccc
     9481 cagagctggt gtgcccggct gctcgtggtg gcgtgccaga agccgccgtc ggcggtgcgc
     9541 ggatagctgt ccaggcgctt gcggatcttg tgtgcggcga tccggtagcg gtccgcgccg
     9601 gtctcgtggt gcaggatgac cagcagtcgg ccggcctgca tgctgtccag gctgttgaag
     9661 ccctggccga tgttgcccgc gtcatcgacg aaccggtcca cgtactcctt gagatagtcg
     9721 agatagcgct gctggtgggt gcgcaggtag acgaggtact ggccgtagag gtagaggccg
     9781 accgggtagg accagccgcc gatcgtcgcc ggggtgtagc gggcgagggt cgagtcggtc
     9841 agcgccacgg accagtcggt ggccgctccc ggccgggtgg tcgccgcctg ccgcgcgggg
     9901 gtgcccggct ccgggtgtgc cgccgcggcg ggcgggccgg ggagcacgag ggcggcgcag
     9961 gcgaggagcg cggcggtcag cgcaccgcgg aaccgggcgt tcatctcgcc cccttcgggg
    10021 cggccggggc gcgccgggcg ggtttgcgcg gccggcccag gcccgcgggg gccccttcgg
    10081 gcgaggcggt cacgaggtcg cgtacgaggg cgtggtccgg ggagagccgg caggccgggt
    10141 cggtcgccgc ggcgtcgccg gtgagcgcga acgcctggca gcggcatcct ccgaagtcct
    10201 gttcgcgcag cgcgcagccg cggcacggtt cgcgcatcca ctccgtgccc cgatagcggg
    10261 tgaacgccgg ggagtggtcc caaatccagg ccagcggccg gtcccggacg ttcggggcgt
    10321 cgagtccggg gagtacggcg gcggccggac agggcagcgt cgttccgtcg ggggtgatgg
    10381 tgagcgagac ggctccccaa ccgcccatac agggcttggc cttgccgtcg aagtagtcgg
    10441 ggaccaccca gaccagctcg gtccgtccgg cgagctcggc gcggcggcgc cgtacggtcc
    10501 gctccgcgcg ggcgagctgc tcgcgggagg gcagcagttc ggcgcggttg cgcagcgccc
    10561 agccgtagaa ctgggtgttg gcgagttcga tacggtccgc gccccaggcc gtcgcgagat
    10621 cgatcagctc gtccagcgcg tcgaggttgt ggcggtgcag gacgacgttg aggccgagcg
    10681 gcagcccgga gtcccggacc agggcggcgg cccgttcctt ggcggcgaag gagcggcgcc
    10741 cggcgatacg gtcgttggca cccgggtcgg cgtgctggac ggacagctgc acactgcgca
    10801 gcccggcgtc ggctaggcgg ccgaggcggt cgcggccgag gccgacgccg ctggtgacga
    10861 gctgggtgtg gataccggcg ccgtcggccg ccgcgacgat ctccgccaga tcggaccgca
    10921 gcagcggctc cccgccggag agatgggcgc tgaccacgcc gagaccggcg gcctggcgca
    10981 gtgcgtccac ccactgctcg gtcgtcaact cggctgatct gcgggtgagt tcgagtggat
    11041 tggagcaata ggggcagtgc agcgggcagc cgtgggtgag ttcggcgagc agcgcccagg
    11101 ggcggggcgg caggggcgcc ccaggcgggg cggcgggctc cggcgggcgc tccccgggcg
    11161 cggtcatcgc agccagcctt cggcgcgtat ccggccgagg aacgccggca cctcggccgc
    11221 caccggagca tccgggtacc gcacggccag ctccgccacg atgtccggca cggcacgcac
    11281 cccgtcacag agccgcagca cggcgcccgc gctcccttcg aggacgacga cccgctccgg
    11341 caggagcagc agatcggtgt cacgcacccg gtcgtggcgc aactggacgg cgggggccag
    11401 ggcggggcac caccgtgtca tggccgctcc ccgcgctcga cggcgtccag cagcgaccac
    11461 agcacctggc atttgaaggt cagcgcggcg accgcgaggt cctgttcggc gtcggtgcgc
    11521 gcccagtcca ggacgagggc cagcgcttcc ttgctgtccc gccgcccctg ggcctgccgg
    11581 ccccggaagt aggcgagccc ctcctcgtcg atccagccgt agtgccgttc gaaggcgtcg
    11641 atacgggtgc gcatgatgtc cggggcggac agttcggtga gcgaggcggc gaccgcctcc
    11701 agcggggtgc gcagccggca gaagttgacg tagccgtcga cggcgagccg tacgcccggc
    11761 agcacgcccg cctcgtccag cagcagcgcc cggtcgagtc cggccgcttc gcccagccgc
    11821 agccagcgtt ccaggccgcc ttcgccctcc cgctgcccgt cgtggtcctg gatccggcgc
    11881 agccacatcc ggcgcagctc cggtgtgccc agcttcgcgg tgatcagggc gtccttgacg
    11941 gggatgcagc gctggtagtg gaaccggttg cggatccagc ggcgcagctc atccggtgtc
    12001 aactcccccg cgtgcatacg gaggttgaag gggtgccggt cgtggtagct gtcgcgtgcc
    12061 acggtccgca gccgctcctc gaagggcgtg ctcatagggc gatctccatg ccttccgcgg
    12121 ccaccgcgag cccctgttcg gccagccgct cgtgctgcgg cgctccgggg tccacgaggg
    12181 ggttggtgtt gttgaggtgg gtgtagaggc agcgggcggc gagcggggcg agccggcggg
    12241 cggtgccggc cggcccgtcg atgggcagat ggcccatacc ggtcgcggtc cgggtggaga
    12301 atccgctgcg gcgtggttcg tcgtcgtccc agaacgtgcc gtcgaccagg acgcagtcgg
    12361 catcggccag cgcgtcctgg aacgcgtcgg accaggcggc gagcgcgggc gcgtagacgg
    12421 cggtgccgcc ggtgcggcgg tcgtgcagcc gcagggcgac gacccacggt tcggggccgg
    12481 cgtcgggtcc ggccgggccg ggggcggcgg ccgcgtagcg ggggcgcttg gcggagaccg
    12541 ggacggcgct gatctcgacg tcggatccct cgcgcagtgg aacgggccgc gcgcccagct
    12601 cccgccatac gaggtccgcg tacggcgtga ggacggcgtc caggtgcgct tgttcgcaga
    12661 gtgcggtgcg gacgcggccg gtggcgagga tctcgatgcg gtcggcctcg cggagccgtg
    12721 cgatgccgag ggtgtggtcg agttcggcgt cggtgaggac cacgcccgcc accggggtcc
    12781 ggcgcgcggc ggggcccggg tgcaggtcgg ccgtgctctc gatctggtcg gcgatatcgg
    12841 gggtggcgtt gatcagatac cagtggtcgt cgtcggctcg tacggcgagc gaggcgtggc
    12901 ggcggcgccg gtcgggatgg tcgcgtgccc cggtgcatcc ggggcacgcg cagttccact
    12961 ggggcacgcc gccacccgcc gcggtgccga gcacccgcaa cagcatggcg gggcggtcag
    13021 cgggcgttca gggagtaggc ggtgacttcc agcgcggtct cgatgaccgt gtagtccggg
    13081 gcctgccagg cggtccgctc gccgtgcggc gcggccgggc cgggggtgtg cggcggctgc
    13141 gagttccgcg ggggctgctc catggcgtcg ttcatgtggg gtccagcctt tcgtgtgggg
    13201 gtcggtcgcg gtcgcccgca ccgcgctcgt ccgagggccg tcgcccgccc ggtggccggg
    13261 gacggtgggc cggggcagcc ggcgccgccc ggtccgcgga gggagcgcgt gccgcttgcg
    13321 cgtccgccgg cggccgggtc cgccgacggc ccgggggcgc cggccgccgg cggatcgccg
    13381 gccatgtcgc gtggcggtgc gttgtcatgg cgttgccgtg tgttgcatgg tgctgctctg
    13441 cagaatcccg agcttggggg gcgcggtcaa tggggcgggg caaaaaatga tccgacctat
    13501 ggagcgatca cgtctctgcg gcgaaccccc cacaccggca atccgcctgc tcaccccgca
    13561 cttcagcagc atctcccacg gcacacaccc ggtccgaaga tcttcggacg ccaactcacc
    13621 ccgacgtgcg gggagatacg tcctaccttc ccgtcccttg acccctgccc atgggcgcag
    13681 tagtttccgg gccggaccat taggaaactt tcctatcagc ctggcgccgc tgatgcccgc
    13741 ccccgaggga acaccccgtc acatctgcct gaccggagga ccccccatgc gcatgcgcac
    13801 caccacagcc cggcacgcct ccctcaccgc ggtggccgcc gccactctgg ccaccggcct
    13861 gctcatcgcc gcggccggca cgggcggcgc cgccaccgcc ccgcacagtg ccgccacgac
    13921 cacgacgaac agcgccaccg gaggcgccac agcgacgggc cgtgcggccg ccgctgccac
    13981 ggcgcccggc ctcacctcgg cacccggctc gatcaagacc atctcgtcgg actggtccat
    14041 cccatggggc ctgagctggc tgcccgacgg ctcggccctg atcaccgagc gcgatacgtt
    14101 caaggtcttc acgctcgccc aggacggtac gaagaaggag atcggcaagg taccgaacgt
    14161 cgtcaccacg ggcggcgagg gcggcctgct gagcatcgcc gtatcgccgt cctggaagac
    14221 cgaccactac gtctatctga tgcacaccgc ttcggaaggc aaccgcatcg cgcggatgac
    14281 cttcaacggc ggcaagctca gcggctacaa ggtgctcgtc gacggcatca agaagaacaa
    14341 gtaccacgac ggcggacgcc tcaagttcgg ccccgacggc tacctctacg ccaccacggg
    14401 cgaggcccag gaccgaaaac tggcccagga caagtcatcg ctcaacggca agatcctgcg
    14461 gatgaccacc gacggcaaac cggcccccgg caaccccttc ggtacgctgc tctactccta
    14521 cggccaccgc aatccgcagg gcatcacctg ggacgcccaa ggccgcctgt gggaggcgga
    14581 gttcggcgac gccaagtacg acgagctgaa cctcatcgag cccgggaaga actacggctg
    14641 gcccacctgc gaaggcacct gctccgtcga cgggatgacc aaccccaagc ggcagtggcc
    14701 ggtcagcgag gcatcgccca gcgcggtcgc ctacgccgac ggagcgatct acatggcggc
    14761 gctgcgcggc cagcgcctgt ggcgcatccc ggtcgacggc accaccgccg gcacccccaa
    14821 ggcgtactac accggcgact acggacggct gcgcacggtc gagaccgtcc ccggtaagaa
    14881 ctccctgtgg ctgaccacca ccaacgccga caacaacggc aaggccgggc ccggctcgga
    14941 caaggtgttc caggtcgatc tgaagtagcg gcggttccgt ccgccactgg caccggttgc
    15001 gcacgaagcc cgtacggcgg tgcggcgcgc cctcggcgtg ccgcaccgtg gcgtccggcg
    15061 acggaccgtg gcttcccgcg gcggaccggc cgaccaccca ccgtgacgtc cgatttccgc
    15121 cagccgggcc gtccccggac ccgcagactg gaacccaggc gaccaccagg cagccgaccg
    15181 cggcggcgcg gaccacgacc gggccgccgc gcacaaggcg cggccgagcc accacccgcc
    15241 tcgggcgtct tggcccggac cgccgcccgc gtggcacgct gatatgagca gcgggacgcg
    15301 agcggcggcg tggtgcggcg gaccggtacc cggcgggacg aaacgagagc ggcggacgag
    15361 ggggacgaga cgggtgagtc acgtatgagc acaccgctcc ctggtttcga ggacttcggg
    15421 ggacccatgg gttccgcacc ccccggagag gccctcggcg aaaattccgg cgcgggctcc
    15481 ggcggccgtg gtgccccggc ggccgtcggc cacgccccgg gccgtcggca gctggctccc
    15541 ggcgccgtcc acgtccccgg ctggctcacc ctggcgcagc agcgcgaact cgtcgccgcc
    15601 tgccgcggct gggcgcgcgg tccggtcccg atccggcaca ccagactccc ccgcggcggc
    15661 acgatgtccg tccagacggt gtgcatcggc tggcactggc agccgtacgc gtacacccgc
    15721 accgccgacg atgtgaacgg cgcccgggtc gccgcgttcc cggactggat ggtcggactg
    15781 ggccgccgcg cggtggccga ggcgtacgag gacgcggcgg cgggtgacgg ctacacaccg
    15841 gacaccgcgc tgatcaattt ctacgacggc caggccaggc tcggcatgca ccaggacaag
    15901 gaggagcggt ccgacgcgcc ggtggtctcc ctgagcatcg gcgacacctg tgtcttccgg
    15961 ttcggcaaca cgcggacgcg caccaagccg tacaccgacg tcgagctggc ctccggggac
    16021 ctgttcgtct tcggcgggcc gtcccggttc gcgtatcacg gggtgcccaa ggtccggccg
    16081 ggcagcggcg accccgcgtg cggtctggcc ggcggccgtc tcaacatcac gatgcgggtc
    16141 accgggctgg gctgaaccac gcccgccgcc cacgggcgcg gtcgccccat atccgggccc
    16201 ggcgcccccg cgtccggccg ccgggaggga gactggaggc atgtgccgaa gcatcaagac
    16261 cctccgtccg cccgtcacgc ccgaggtcac cgaggaggac atccgggccg cggccgtgca
    16321 gtacgtgcgc aaggtctccg gattccgggc gccggccgcc cacaaccgcg aggtgttcga
    16381 ccacgccgtg gagagcgtgg cggccgcgac gcgggaactc ctcgatggcc tgcgcgtccg
    16441 cggctccacc gccacccgca cctgacccgc gcgcccggcc cccacgggtc accggtcgag
    16501 cagcgcctgc accggcaggt gatcgctcgg aaaccggccg tgctcggcga acgtgttgat
    16561 ggtggcgcgc cgggtccgca cccccggtga ggtcaggatc cagtcgaccc ggtcgccgtc
    16621 cggtaccagg ggccggtagc cgtgaaaggt gccgtactgc gcgctgcgtc gcgcggccgt
    16681 gtcccagctg tccacgaggg tcccgccgcc gagcatcgcg tcgtagacgg gattgcggtg
    16741 cgccgcgaca ttgaagtccc ccgtgacgat ccggggcagt gcggggtcca gggcggccag
    16801 ccgctccgtg atcagcgcgg cggaccgctc gcgcgcgtac tggtgggcgt ggtcgaggtg
    16861 ggtgttcagg gcgtagaact cgccgcccgc gtgcaggtcc cggaagcgga cccaggtcac
    16921 catccgtacg acggtgtttc cccaggtggc cgagccgatc aggagtggcg tggcggagag
    16981 ccagaagtgg tcgtactcga ccggtacgag tcggtgtacg tcatagaaga cggccacgaa
    17041 ctcatcccgg ctcccgccgc cccgccccgt ccccacccag gcgtaccggg ggccgagatc
    17101 cgccgcgata tcgcgcagtt gcccgtacag cccctcctgc gtcccgagca ggtgcggggc
    17161 ctcgcggcgc agcagtgccc gcatcacggg gcggcgctcg gcccaggagt gcggcggggt
    17221 gtccgacgcg taccgcaggt tgaaggtcat cacccggagc cccggcccgc ggtcggcggc
    17281 ggacgcgggc ccggctccgt acgccgccac cggcgcggtc accgccgtgg cggccgccgc
    17341 ccgtagcgcg gagcggcggc tgaccggcgc cgccgcgggg gcggagccag gtggatcttc
    17401 cggtgcggca gcgaggacgg gagcgatcac ggcgactcca gggatccggt acccggcggg
    17461 ccccggcgaa ggccggcgcc cgtcacccca gcgtcccgga taccgcgccg cgccggaagt
    17521 ggccgccggg cgaagccgat cggaacagtc ggccggcctc tctgctgctg ctcaccggcc
    17581 gccggcgggg ccctgccagt ccgcgtaccg gatgcgtgcc atctcccgga cctcgccgag
    17641 cgtgccccac tcgttcttgc cgagccgcga caggggccgc agccgggtga tctcggggtg
    17701 gccgtccatc agcacgtcct gcgctacggc cgcgtgcacc acccgtccga acacgatcgt
    17761 cgagtcaccg atcccgagcg tgctgtacgc ctcgcactcc agcgccacgg gcgaggccgc
    17821 gacccgcggc ggctcgaccc gcaggctcgg ttcggcggtg atcccggccg cctcgaactc
    17881 gctcgtcctg tgcgggaaat cgacggcgga gtcgttgatc tgctcgaaca tcccctccgg
    17941 cgcgaggttc accacgaact ccccggtggc ctcgatgttc cgcaacgaat ccttgcggcc
    18001 gacagaggtg aactgcacca ccggcggcgc cacactggcg atggtgaaga acgagtgcgg
    18061 agccaggttc gcgacgccgt ccgggccgat ggtcgacacc caggcgatgg ggcgcggcac
    18121 gaccaccgcg gtcaacagcc ggtagaactc gttacggggc agcacagcgg ggtcgaagtc
    18181 ggtacgcatg atgacgagta tcccggaggg cggccccgga ccccagggtg atccacggcg
    18241 ctgcccggcg agaacaccgc gcgccgacac ctctccgccg cccgtgggga cgacccgggg
    18301 cgacccacct gccgcgtccc gcgcaggtca cccgccgttc cgtgacgcca tggcgtggtc
    18361 gggcaggtcg agcgcttccg cgggcgggct gaacagtgct cccgcgccgc ctacgagccg
    18421 gttggccagg gggctggcgg ccgcccgtag tccggcccag accagcgagc gctgcagtcg
    18481 ggtgcggggg tagaacatgt aggggaaccc gggccggagt tgctgggccc gctcggcgaa
    18541 cgggcgcatg accgcctcgt aacgggcgaa cgcggcctgc ggatcggtgt ggcgggtgag
    18601 ctcgcccgcc agaacgtagg cgccggtgac ggccagggtc gtccccatac cgctgaccgg
    18661 cgaggcgcag taggcggtgt ccccgagcag ggcgatccgg ccgctgctcc agcgcgggag
    18721 ccgagcctga ccgagcgatt cgaagtacag cgggctgtcg tcgagggcgt cgaggatccg
    18781 gggggtttcc cagccgatgt cggcgaaggt cgcgcgcagg atcgtgacga tgtccgcgcg
    18841 gtcgagacgg tcgagtccgc gcgtggcgct gtgcatgttc agcgaagccc gaatggtccc
    18901 gacgtcgtcc ggccgcaggg tcaccccgcg gccgcggtcg gcgatcagcc accgccaccg
    18961 gttgttgtcg gcatcagtgc gcgggattgt gaagtaggcg ctgtagaggc cgagttcgcg
    19021 caggcgcacg tcccgtatca ccagcgagcg ggtgcgcgaa cggagcccct cggcgatgac
    19081 caccgcgtcg aaccggcggg ccggcccgtg gcggaactcg acgtccacgc cgtgcccgtc
    19141 gtcgtgcagc gcggtgatct ggtcgccgaa gacgtatgcg gcgtcggtgg acgagtggtc
    19201 gtggaggatg cgcgagagtc gcccgcgcag gatctccagt tcggcggtgc cgcccgaggt
    19261 gtcgtcggtg ccggcggcga tacgcgcgac cggcctgccc cgctcgtcga cgaagtccag
    19321 gccggtctcg tgggtgtgcg cggcgcggac aacgtcttca aggcccatcc ggcggagcac
    19381 ttcgcggccg gtaccgcgga tgtcgatgtt ctggccctcg tcgcgcagct ggtcgaagcg
    19441 ttcgatgacg gtgacgtccc agccggcggc gccgagccag gaggcgaggg tcggtcccgc
    19501 gatgctggcg ccggagatga ggatgctcgg agtgctcatg gtggcggacc ttcctgtcct
    19561 ggtcacgggc gcgaaacccg gtggcgtcgc gcgctcatac ctcccccgcg ggtcgcccgg
    19621 ggcggcggcg gtgggcggcc gctccgcccg gccacggacc gcaccggccg ctcggcgcgc
    19681 cgggcggccc cgatccgccg gcgaagacgg ggcggcgtcc cggttcgccg cccccacacc
    19741 gcccggtgcc ccccggatcc gcagaagtgc gggtccggcg ggggtgtcga catcacacgc
    19801 ccgctctcgg tggaatgtag accagtccgt gagcgccttg attgtgcgtg ttcttcgaga
    19861 actccccgcc tgggtcgccg aggtccactt cgagagtggt gaccggggtg tgggcgtcga
    19921 ggtccaccac ggtgacggtg ccggcgatga ggtgggagac gaacgcgagg tgcccttcgg
    19981 cggcggagat gatgttgatg ggggtaatgc ccacgttcaa ctcgccgagg taccggtagg
    20041 tttcggcgtc gaggatcgac aggatgccgt ccgcgaacgg attcgcgcgg gagcccgaca
    20101 gcggccagca gcccaccagg agtttgcccg tgccggtgac gtgcaccggg cccggtgtcg
    20161 cgggcagcgc gatcgcggcc agggtggtga gggtcgtggt gtcgatcacc ttgacggcgt
    20221 gtggtgcggt ggggtcgggc ggagacagag cggtcggcgt ggcgatgtag agccggtctc
    20281 ccgcgggaga cagcgcgagg ccctcgctgc cggggaccgg gatacgtcgc acgggagtcc
    20341 ggcccgtcag gtcgatcctc gacgcgaaga gcgcgctctt gttggtggtg taggcggccg
    20401 tgccgtcggg tgccagcacc gcccagtgcg gcaccggcgc gtcggcggag taccgggcca
    20461 ccacttcgtt ggttcgcagg tcgatggcga ccagtccgcc cggaccggcc ggcccctcct
    20521 cgacgctcac gtaaagcagg tctgccgcgg cgtcgagggc gagggcgtgc ggaccgtgtt
    20581 ccggggcgag gtcgatcacc tcgacgacct ggtgggtgtc gacgtcgatc acgctgacct
    20641 catggccctt ttcgtcatgc gcggcgaagt ggcccgatcg gtaggtgtgg ctcgcgtaga
    20701 ggcgccgccg cacggggtcg aagcagagtt cgtgcccctc gggcagcacg ggcacgatgt
    20761 cgctgcggcg gccggaggcc agatcgaaga aactcagcgt gtggccgctc tgactcagca
    20821 ccgccagctc ggcgccgacg ggaaacgagg tgctcaagac tcccccatca agagttggga
    20881 cagatcacgg gcctctccgg ccgtaccacg tgatcacgca ctacgtggcc tggccatcca
    20941 tatcaacata cgtcaaggct ctttgctggt gagggatttc gcgccatgga tgatgttgcc
    21001 gccggcctgc tcggagtcct cgacgtgtgg tgatcgacca gcggcgtgac ttggcagctg
    21061 gccggacgaa cacctcgccg ccggtggcag cggcgagccg tagcctcgcg aggctgcggg
    21121 gaccacgggc gatgcctgcc ggttcgcggg ggcggggtca ggcggccacc tcggccttct
    21181 ccggcacccc cgaccacatc cgggaccgca tccgggaccg actcagcgcc tacgcacggg
    21241 gcggatcacc gagatcgtct accagcccac ccgccccgac atccccggcg aactcgaacg
    21301 ctgcatcgcc atcgcccgtg acgtatagcg ggcttgtcgg tcgttgcggg gcagggaccg
    21361 aatcgcacct gcggtgattt tgcggccgca gcggacgccg ctccggacgc actgcccgca
    21421 gcggccccgc acccctcccg ccaccgctgt tgggcggaca gccccgcggc agccccctca
    21481 acccgtcggg ccggccggat ccgaggcggt ttcgtcccgt ctctcgacgg ttctcatatg
    21541 acgctgtcgg ttcgcaacgg gccggcggtg atgtgcaggg tcctgatacg cgcgggctcc
    21601 gcgccgtcga gacgatagat gtgcatgaac ggggcgcgca cgacagcgtc gggggcggtc
    21661 ttcttcgcca tggtggcttc cccgcgcagg atgtggacgc cttgggctgc ggtccagtac
    21721 tcgacgactt cgtgggtgat gtcgaggggt tcgtcgatct tcacgaagaa tgccttgatg
    21781 gcctcgacgc cgaccacgtg cgcggtgccg aagtacatct cggtctcgtc ggtcatgcgg
    21841 gcgaatccct cgccgaaggc gagcgtgtcg atctcgtgca tgatctggag cacccaagtg
    21901 ggcggtgcgg cgctggtcgc ggtgggggtc ggtgtcatcg ctccgctctc tttcaggctg
    21961 ccacggcgga caggccggcg aggtaggcgt caacttcggc aggggcctcg cccgggtcct
    22021 cgggggcggc gaggcggccg gtgcgcggca gcacccggaa ggtgatccct ctggtggcgt
    22081 cggccatctt ccgta
//
