LOCUS       NZ_NDXL01000001        25150 bp    DNA     linear   CON 27-APR-2024
DEFINITION  Streptomyces kasugaensis strain BCRC 12349 scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_NDXL01000001
VERSION     NZ_NDXL01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces kasugaensis
  ORGANISM  Streptomyces kasugaensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Comparative genome analysis for kasugamycin overproduction
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Comparative genome analysis for kasugamycin overproduction
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,
            China
REFERENCE   4  (bases 1 to 5071473)
  AUTHORS   Liu,X., Zhu,C., Bai,L. and Jiang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. May-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 188.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002261115.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 02:42:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,951
            CDSs (total)                      :: 7,863
            Genes (coding)                    :: 7,657
            CDSs (with protein)               :: 7,657
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 4, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 206
            CDSs (without protein)            :: 206
            Pseudo Genes (ambiguous residues) :: 0 of 206
            Pseudo Genes (frameshifted)       :: 87 of 206
            Pseudo Genes (incomplete)         :: 170 of 206
            Pseudo Genes (internal stop)      :: 23 of 206
            Pseudo Genes (multiple problems)  :: 65 of 206
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:37:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 553313
            Orig. end                         :: 578463
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NDXL01000001.1.
            Bacteria and source DNA available from BCRC.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25150
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aureonuclemycin"
                     /region_number="7"
                     /rules="(her4 and her5 and her6 and her7)"
                     /tool="antismash"
     cand_cluster    1..25150
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(her4 and her5 and her6 and her7)"
                     /kind="single"
                     /product="aureonuclemycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25150
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15150](-)"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15150)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
     misc_feature    complement(83..96)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.19"
                     /tool="antismash"
     gene            189..374
                     /locus_tag="B7024_RS02385"
     CDS             189..374
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_094790939.1"
                     /transl_table=11
                     /translation="MRGAGREVGAEVLAHISPARGSVVNHYGSITVDHDRELARLDEQG
                     HRPLRTLAVDESGAGL"
     gene            complement(880..2094)
                     /locus_tag="B7024_RS02390"
     CDS             complement(880..2094)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082404.1"
                     /locus_tag="B7024_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_094790940.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.2e-20, bitscore:
                     71.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTAITNARVFDGEKTLGVQTVVIDGARIARVGGDAPPDSEIVD
                     GSGATLLPGLIDAHVHSAPGSLALALRFGVTTELEMQGMNTRENRGLITDDDTVADVRS
                     AGFAITPPGGHPSELMPEGFRPKWDLPPVMPLMPFSTTPEEAAAFVPQLLARGSDFIKF
                     MIDDGSVEGHPGLPSLDQATVNAGVAEAKKYGALTVAHALTVEATRMAAEAGVDGVAHV
                     FMDQPHADEIIGLIKDASMFVIPCISLNASMMGITGSALADDPRVAARLDSKWDRTLRS
                     SYNRYPQGKLDDVYDTVRALDTAGIDVLAGTDVSMPETFFGGLAHGASLHHELQYLVAA
                     GLTPSRALRAATATTARRFRLSDRGRIAEGLRADLLLVDGDPTGNITDTLNTRAIWRRG
                     TRLTE"
     misc_feature    complement(2128..2148)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            2195..2662
                     /locus_tag="B7024_RS02395"
     CDS             2195..2662
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047755.1"
                     /locus_tag="B7024_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_094790941.1"
                     /transl_table=11
                     /translation="MSSASSSERTPDDLVLDQIGPALSRLRRRAPASSKDLSRNLVLNV
                     IADAPGETTVGGLAAAMGVAQPVASRTVAACIEEGLLRRAASQSDGRRTVLELTEHGEA
                     ERNRFAAEQRKAFQEITAAWPPEEQIQFARLLVRYGADAAAWSGKQATSRD"
     gene            complement(2743..3447)
                     /locus_tag="B7024_RS02400"
     CDS             complement(2743..3447)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574007.1"
                     /locus_tag="B7024_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_094790942.1"
                     /transl_table=11
                     /translation="MDEDRRAARYQVLQVAAELLEEGGGEAVSTRAVAAAAGITAPTLY
                     RMFGDKDGLLAELAVHGFERYLAEKREALSRSEDPVADLYRGWDLHVDFGLRHPAFYLL
                     MYGTARPGRKPPAADEAHALLVGLLDRAAADARLRVPVEEASRVVHAATTGATLALIGE
                     EAPHRNLSTSTRLRNIVIGSITTGPPVATAADLASRALALDAALTVEDGATPPLRDTET
                     ALLRDWLHRLAE"
     gene            3728..4312
                     /locus_tag="B7024_RS02405"
     CDS             3728..4312
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574006.1"
                     /locus_tag="B7024_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavodoxin family protein"
                     /protein_id="WP_052858661.1"
                     /transl_table=11
                     /translation="MSDTTIAIASYSGYGHTAQIAAAVADGAHSVSGTQVHRVDVASLS
                     DADWEVLDCADAIIFGSPTYMGTASGAFHAFAEATSKRWMTRAWSDKLAAGFTNSGSMS
                     GDKMHTLQYFAVLAAQHGMLWVSLGLLPGWNTTTSGPEDDNRLGFYLGAGAQSFNDTAA
                     VHDADLSTARHLGRRVAEQTRIHRDGLAARR"
     gene            4383..5864
                     /locus_tag="B7024_RS02410"
     CDS             4383..5864
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574005.1"
                     /locus_tag="B7024_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_094790943.1"
                     /sec_met_domain="Aldedh (E-value: 3.2e-150, bitscore:
                     498.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTETPIQRLLIGGAWQQAADNRIYAVHDPFTGHVASRAAAAR
                     TADVVRAVEAAEQAFGAWAGLAPSERRRTLWTAAERLAARAGELTEAITAEMGGPAAWG
                     AYNVKVLTEKIRYAASAAHEGLTGQVIPSETSGRTSIAIRKPVGVVAGIIPWNAPALLV
                     GASLPAALVLGNTVVMKASEQTPRTHGLVAECFTEAGLPDGVLNLVTNAPEDAPDVVDA
                     LIAHPAVRRVHFTGSTRVGRIIGEKAASHLKPAILELGGKAPVIVLADADLDHAVSAVG
                     FGAFANSGQGCLSTERVIVDRAVADEFTGRLAALAATITCGDPRDPQTVLGPVVGRNAV
                     SRLTDLIQDAVGAGARLLAGGTANGPCFAPTVLADVAPGMRVYREESFGPMVTVGIVDG
                     HEEALRAANDNDYGLTSAIFTRDIPLALNLAKRINTGMCHINGATLDDEPQIPFGGVKN
                     SGYGKSGGRAGLEEFTELQWITIEGPQAPRYPITE"
     gene            complement(6366..7466)
                     /locus_tag="B7024_RS02415"
     CDS             complement(6366..7466)
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579249.1"
                     /locus_tag="B7024_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase"
                     /protein_id="WP_094790944.1"
                     /transl_table=11
                     /translation="MTTPQPEDAFPADSPHAIIDVAVAFWKSKALLSAVELGVFEELAI
                     RPATRAELTGRLGIAGRGAADFLDALVSLGLLERDGGVYRNSPVADCHLDPRKPATDIS
                     GYLSFLNAGFGCWAGLTDALRSGGRLDFSAALAASQSADQGGAGDPKLVGADATDDTFG
                     EAYAAPDQVTGFLRAMTGYSMGANQAIAERYDWSGSRTVADVGCAEGSLLAQVLSRNPH
                     LQGIGFDLPVVGPGFDAHLERVGLTDRARFAGGDFFTDPLPTADAIVMGHVLHDWDLDT
                     KKTLIGKAYEALPDGGRLLIYESLIDDDRRERTTGLLISLNVSTVSAGGLGYTGAECGD
                     WMRAAGFRDIAVSHLDGPEYLVVGVK"
     gene            complement(7525..9147)
                     /locus_tag="B7024_RS02420"
     CDS             complement(7525..9147)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941300.1"
                     /locus_tag="B7024_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_094790945.1"
                     /transl_table=11
                     /translation="MSAACTAPHESRTAAPAAHPLFSREWLRHAEATAGQRPAEGEALR
                     LGLRLTDPPAGVAGQILVLTDLATGALWFRAGEWDERPTLVLTLRHEEAAVLLFGDAER
                     RVRLFEHGRLVLEGVFLFIFFLDRLLQQDPSGALARLRGFTADAPQAAGPWPGAAAAVT
                     APDAEADAVRAATEALPRTMAALRAELGRTTPGAQLHVSHVPSGTTVSAALGSCRPGVP
                     FTRASLPIWYCCSKTLGAVAIGQLWERGLLDPAAPVARYLPWYDGDGRERVTLYQLLTH
                     TSAVPMGLDPLHGAMAAPVALRRELLRNMTVPAGTPPGARINYGPWWAWFLIAEVVRAV
                     DGRDYERYLAEEILAPCGMTDTRVVLTPQEYRAEADRLPLIHITGGGLPAQPTHWYATE
                     ASCTRPIPGLNIRGPMSDLALFFAALADGGRGRHGRILLPQTVMALTAHHRVGLVDPFG
                     NADWGLGFRVESRHLGDACTAFSRHASPRTFGHYGLWTSAAFADPDAGLVVALHLNGKT
                     WQEEHQERMITIGDAVYQDLRLT"
     gene            complement(9144..10004)
                     /locus_tag="B7024_RS02425"
     CDS             complement(9144..10004)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576689.1"
                     /locus_tag="B7024_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_094790946.1"
                     /sec_met_domain="PCMT (E-value: 4.4e-09, bitscore: 34.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTLRHPAPDEHKEALARLFDRSAPTYEKVGVSHFDALGRQLVA
                     EARVREGERVLDVGCGTGAVLVPAARAVGPSGSVTGIDLSAGMVERSRAAIAEEGLGNA
                     RALVADAETAHWQPGPPVDGTFDAVLAGISMFFFPHPRAAAARYRRLLADGGRFAISWW
                     GRQDERWNPVFAASAPYGGASSHRLPPDSPFRSVEDLHAMLSEEGFSSVDTVERTCVTR
                     FRGPHQWWQWVWSTAGRQFWESVPEDAMADAVKAVEAELAGLRAPDGSLTSRNTVRFTV
                     AEVAR"
     gene            complement(10001..11113)
                     /locus_tag="B7024_RS02430"
     CDS             complement(10001..11113)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576688.1"
                     /locus_tag="B7024_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_094790947.1"
                     /sec_met_domain="her7 (E-value: 3.2e-205, bitscore: 679.3,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 8.4e-24, bitscore:
                     82.6, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 7.9e-30,
                     bitscore: 101.4, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRFGILGCGSIGGFLGRLLAWPDGTLRERATLVAVAEQDAVQAH
                     RLAAELGCEALAVPELLARTDIDAVAVCTPSGTHAELGTAALRAGKHVLVEKPIDVTLE
                     AADRLIDAARHTGRTLGVISQHRFDPAAEVARAAIEDGTLGRITSVLIEVPLWRARSYY
                     ASGQWRGTRALDGGGALMNQAVHAVDLAQWLAGPVVEAAAHTGRLAHDGIEVEDVATAS
                     LKFAGGALGALLATTAAYPGRTTRVAVNGERGSVVIDNDELAYFHAAREGERPAAYGAY
                     GDGNQAADRCPPPPEPPPRDRIGLLHQPHRDQLADFCDAVRTGRPPLVDGAAGRRAVAV
                     VHAVYTSARTGRTVRLDESGNLTQDKGRTP"
     gene            complement(11123..12430)
                     /locus_tag="B7024_RS02435"
     CDS             complement(11123..12430)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941308.1"
                     /locus_tag="B7024_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_094790948.1"
                     /sec_met_domain="her6 (E-value: 4.1e-255, bitscore: 844.3,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRICLVIPSNKFDQYFIQLPLDAVTAAGQLRAEGHTVTVWDQRL
                     QEAPDGEECDLLVVFSAIADRAQCYPLELDSVRAAVERAASRYPTARTVAVGPHGTHLP
                     ASTRAELGVDHIACGETDSATVGAVRALLAGADAPVLPGAATPHNLLDSPEPRPRPFPN
                     LPLEELAFPAYDLVPTADYTAEVISGGLPLPGPCGMVLAARGCTYGCTFCHLPFGTKMR
                     NQPLDRVVREIDAQQAAGLEFVFFLDYVFGINRTFYGELCARLEGRGVGWVGQTRAEVV
                     LKNDVTAWARAGCQGMWLGAESPAIADTGVHKRVSEAQIEEAVLKLRDAGITPFAFVLL
                     GLPQDQACISGRLVDWAAKLPAWFGINQLYLRPGTTLYDQLAPQYNGGVQPATWREVQE
                     VTRRYRAAYPTDLDHQQQRLTELPNYLGNAIAPVTG"
     gene            complement(12444..13565)
                     /locus_tag="B7024_RS02440"
     CDS             complement(12444..13565)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her5"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941309.1"
                     /locus_tag="B7024_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_244933807.1"
                     /sec_met_domain="her5 (E-value: 8.5e-183, bitscore: 605.5,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGRPHVCVVGHGVAGRLHRQLLDAMGISVSVVDPTAPGCGTPLP
                     TAATVGELSTDRPVDVWSVCTPTAGHVQTVTAVLARDPEARILLEKPACRSWEGPELTA
                     LLGAYDRARLVVMNQYAHAKAPAILEAVRAEFAPRHPVAAIRVAFCKDRREDIAAGRFV
                     DLDYGVFGYEWLHMLAVLGGFLPARAFDHYLLAGPEPQAVRIARDPHLVSTAAHDTTTL
                     SAGAGLAGEVEVELYSTIVGPDAPHAAPAPSWARRTAPAADSRLRLARIEAGPVLLTLE
                     LDPVFLPNGTRLPRNTHRLTMDGPHGHREWLIPDSPMDNALRHGIAALLGPGPRPALDL
                     RSLDRIGRLAELARTERPAPSSPPTPAALPTRL"
     misc_feature    complement(13434..13436)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13555..15150)
                     /locus_tag="B7024_RS02445"
     CDS             complement(13555..15150)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941311.1"
                     /locus_tag="B7024_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_278192717.1"
                     /sec_met_domain="her4 (E-value: 1.1e-286, bitscore: 949.7,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEGPLGAGDLLAAVRAVLDGHGGAPARPELTVHGPGQYTVRVGG
                     DRLDIRSRPLSDQPPGTLDPVLDGPGARRIVLTASGAPSERARDLFTALTEAIGRRARC
                     YTAAEAAAIAAGMPLTDRYARPEPALAGWALIFRDHYVENSVGFLLAMERAGLDPEWIF
                     ALSKGDRTQHRERVHSWFLRRGYASDTLDNSVINGTAGAAEAARARAVDAQVADFVRRA
                     HAAGRKVLVIDDGGLLAQGYGADGPGPRVDAAIELTVSGLKRITAAPGELAVPVLNMAR
                     SQLKSRLGYNEIADSCVRRLRAIVPGQKFIGRHVLLLGYGTLGARAARSLRALGCRVAV
                     VDTDILALITAAEDGFETHRSIAEALDRQRPFLILGSSGGTAVTAEDVPLLPDGVLLAG
                     FATKDFSVLTDGYPGATAQRIPHVGVRYDLPHATTATVLGDGRSLNLFEYEGIANRGYD
                     AYRAGTLLAALALCRDPERFPPGLHLEPVDRIIDDAGLFDAYYTQYLCARSAPLGTGAF
                     AGTAETSGEDAHAR"
     misc_feature    15207..15223
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.95"
                     /tool="antismash"
     gene            15262..15429
                     /locus_tag="B7024_RS41155"
     CDS             15262..15429
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7024_RS41155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_165484817.1"
                     /transl_table=11
                     /translation="MRTDLLRLGRNQEALLVRLVFSGQPAVRGILTAIVEIHDPGGRPA
                     RATALVSRMR"
     gene            complement(15413..18175)
                     /locus_tag="B7024_RS02450"
     CDS             complement(15413..18175)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="B7024_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_094790950.1"
                     /transl_table=11
                     /translation="MGSVLLEREEALAAAARAGESARSGAGRWLVFGAAAGTGRTALLR
                     EVTEREAAGGAMCVLRADCSPEESGFPFALVRQLFPEDGEVPFADLPAAEEQMVFHRLV
                     TRLARTADRRSLLLAVDDLHDADMASRRWLGYLARRLADLPVLLVLTECREKGTAVLPG
                     ATGTAVVLRPLGPEAVARLVSARGHGADRAELCIRACAGNPVLVHALLADLREGPLPRS
                     LSELGGSRYRDAIVHWIRTRATPWSRRLSLALAVAGNGAALLGGALLHEAAGLCPDHRA
                     ASAGASALRRLFAHPLAREAALAAADPAELGALRGRIARLLDERGAPTADVAAQLLHLD
                     RPGEEWMTQSLEDAAEDAVRGGRVDEATAFLRHALTAPLAPARRAGLTLRLGALELPHS
                     ADAGIRRLRAALELHADRHERAAVAPALGAALVARGRTDTAMRVMSQVGSAVDDGELDR
                     VLQTTAAVMASHDAVAWRNAVARMRELAATAPAAVEPLAYGLVTEYEVGTGRLSAAEAL
                     GRVLPRLAAPVDPRLRDGWLGTAATLLQWADRLDEARALAEEALPASPALPDLTDIGRQ
                     CLISVRAEAALWAGDFRRVIAENAPLLDACAGQGIRMPHLVSMVALAHCELGNRAHARR
                     LLAGLDEESAGSSWEWNELHCARAFLHMAEGNWQAALDDYLSCGRGQSARDFVSPVATP
                     WRSGAALALVGLGQPARALDLAEEELRHARTWGTPRTVSRALRARAAAVGGRRGLESLS
                     EAVAVLRTAPAPVELVETLLDLGRARIDAGNSRKGREDLHEAHALALRLLAPDPTGHPD
                     APDAPATGRLLRATGNALRASGARGTRRDTTGSAALTRAERRIVELAAQGQTNAQIGEV
                     LHLARRTVETHLTHAYRKLGVTRRTQLASRLTGAGAAASSGARSLIASG"
     misc_feature    complement(17828..17830)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18232..18250)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(18264..>18725)
                     /locus_tag="B7024_RS42120"
                     /pseudo=""
     CDS             complement(18264..>18725)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019122.4"
                     /locus_tag="B7024_RS42120"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="THLGQVMSVAEAAASTRQTTEGVKTAGALLDRARAYDITMPITEV
                     MYVLLHEKATLAEAAAALMQRAPKPERTDQLRNRKNRGSAGGRLPACGKTVRRQRRSVE
                     CGVNRLNRHRAVAAMYHPARSRRHVTHIKTITCPARPCGISLGENAGPE"
     gene            18949..19767
                     /locus_tag="B7024_RS02460"
     CDS             18949..19767
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308133.1"
                     /locus_tag="B7024_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_094790952.1"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-77, bitscore:
                     258.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIAQPDNARLFRSLHTPTEPLALANAWDVASARVIEAAGAAAIA
                     TTSAGVAWSLGSPDGDILSRDRALELIGRIVAAVAVPVTADIEGGYGTDAAGVAETVAG
                     VLAAGAVGVNIEDGTRPPTELATRLATARQTADRAGADLFLNARIDTFLSGLGAPDARL
                     KETLSRARMYVDAGADGIFVPGVTDTATIDALARGISVPLNVMAGPGTPTVAELGVLGV
                     ARVSLGSGVAQVAYAAARRAAQDLFGTGGYDSLTQGMAFPELNALLSDPH"
     gene            complement(19868..20500)
                     /locus_tag="B7024_RS02465"
     CDS             complement(19868..20500)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009323418.1"
                     /locus_tag="B7024_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UbiX family flavin prenyltransferase"
                     /protein_id="WP_094790953.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.5e-27, bitscore:
                     94.0, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTASPTRLIIGVTGATGAPLAVRLLEILREVPHVETHLVLSTWA
                     RSTIEVETPYSSRHCAELTDVTHKFGDLGATISSGSFPVAGMAIVPCSMKTLAAVRHGL
                     ADNLIARAADVTLKERRPLVLVPRETPLNEIHLENMLALSRMGARIVPPMPAFYDIPNG
                     ISDLVDHIVMRILDQFDLPEGTADIAERWQGLTETRSHGPVSDVDRR"
     gene            complement(20575..21975)
                     /locus_tag="B7024_RS02470"
     CDS             complement(20575..21975)
                     /EC_number="4.1.1.-"
                     /GO_function="GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00148.1"
                     /locus_tag="B7024_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UbiD family decarboxylase"
                     /protein_id="WP_216362782.1"
                     /transl_table=11
                     /translation="MTETLGEDEVLRIDGADRDLDIGGITELMAEREGPALMFDNIPGY
                     PAGHRVFTNFMGTAARTAVALGLPRDTPKLDIVRAWKDLSKQLEPVPPVVVPTGPVLEN
                     VLVGGDVDLGVFPTPRWHDGDGGRYIGTACMVITRDPDNGWVNVGTYRACVQGPDRLSL
                     WMLGNRHAKAIAEKYWKRGLTCPIAVVVGQDPILSTAAAIAAPSGMSEYDLAGGLRGQG
                     VEVLYAPGSDLPIPAYAETVIQGELPPVEEESVLEGPFGEWTGYYTHSGQETVVRVNRI
                     MHRNNPIILGAPPMLPTVPAGDQAVPLYSASVTWDHLEASGVQNIKGVWAYARQLMMVV
                     SIEQTGAGDAMHALLAAAGRKRTGGMERYFVVVDEDIDITDIHHVLWAMFTRVDPSESL
                     QVLRTPTTAIDPRLSPGKRAAGDLSMGIVLIDATKPFAWKDQYPAANRVDETTRTELRK
                     RWAGVLTM"
     gene            22220..23209
                     /locus_tag="B7024_RS02475"
     CDS             22220..23209
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077080.1"
                     /locus_tag="B7024_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AsnC family transcriptional regulator"
                     /protein_id="WP_244933808.1"
                     /transl_table=11
                     /translation="MEYLDLQLIHALQIDGRAPLRRIASVLGVSDQMAARRYARLREQA
                     GLRVIGRLNPRPVGQTVWALRLQCIPSAALGLAHALAEREDTRWVQLASGGTEIICHLA
                     VHSDSDRDALLMDRLPSSRRVTSITAHRMLRLFKGGPTTWDGPTSALSREQMDALAPSY
                     PLPHAQAAPVELTELDHVLLAALNRDGRASHAALAAVARCHESTVRRRIAHLRTAGALF
                     FVLDLDGRLLGDPSGTAIWMSVQPSQLAAAGAALAGHPEVAYAAATTGRTNLLANVLCS
                     DDESLYAYLSDRIGALPGVDTVETAPIIRTLKRDGSVARNSSTLRSAP"
     gene            complement(23553..24125)
                     /locus_tag="B7024_RS02480"
     CDS             complement(23553..24125)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.4"
                     /locus_tag="B7024_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_094790956.1"
                     /transl_table=11
                     /translation="MTSKNSEFELGGINHLALVCSDMQRTVDFYSGVLGMPLIKTIELP
                     GGVGQHFFFDCGGGDAVAFFWFADAPDGVPGISAPKSLPGTGEFVSAVGSMNHVAFHVP
                     AERFEEYHARLTAKGVTVSPVMNHDNSASTVAPRMQKGVYVRSCYFQDPDGILLEFACW
                     VDKPLGEEHNVTDAPKTAADRRVATSA"
     misc_feature    24105..24120
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    complement(24372..24388)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.01"
                     /tool="antismash"
ORIGIN
        1 catcgcgtgc agcggcctgt gccatctgct caccagggcg gtctggccgc ccatggtcca
       61 ctcttgggtc cagttggtgg tgtcgaaata gttgtactcg ccgacgggcc accccaggcc
      121 gtccgcgggg tcggcgtcga cgcccgcacc gacacgatca cccgcagcca ggacggaagc
      181 tgaccagcat gcgcggcgcc ggccgagagg tgggcgccga ggtcctggcg cacatctccc
      241 cggcccgcgg ctcggtggtc aaccactacg gctccatcac cgtcgaccat gaccgtgaac
      301 tcgcccggct cgacgagcag ggccaccgtc ccctgcggac cttggccgtg gacgagtccg
      361 gagccgggct gtagccgtga tcggcccggc tccgccccac ggggaggggc ggagccgggc
      421 cgacagttcg atcgccgatg gcgtttcgtc gctccccggc ggagggcggc agcgcctggg
      481 gtcatatcgg gctaccgagc cgctcggcgc cagactgccg ggtgccctcg ctcacaccgc
      541 gccgtcgaag gcgggtgcta ccgacaccac ccgcagcggc acaccttgct gtcctcgtcg
      601 ccctgcttct gttgctcctt ttcttgttcc ttccgcgttg ccaaggcgcc ctcccccacg
      661 agccgtaggc gccgcccgtt gagtccccga cgggcgctgc atccggacgg aaccgtcggc
      721 agtagaaggg gagtctgcgg tcggcgagcg catcggtgcc ggcatgcgcg aacacctggc
      781 cctgcgtgcc ggcgtggcca gctactgcct ggagcagcat cgaacgcata gcgggtcact
      841 cacgcccctc gcccgcatcc accgcctgac ggactgctgt cattccgtca ggcgggtgcc
      901 gcggcgccag atggcgcggg tgttgagggt gtcggtgatg tttccggtcg ggtcgccgtc
      961 gaccagtagg aggtcggcgc ggagtccctc ggcgatgcgg ccccggtcgc tgaggcggaa
     1021 gcggcgggct gtggtcgctg tggctgctcg cagggctcgt gagggtgtga ggccggctgc
     1081 cacaaggtac tgcagttcat ggtgcaggct cgctccgtgc gccaggcccc cgaagaacgt
     1141 ctcgggcatg gagacgtcgg tgccggccag cacgtcgatg ccggcagtgt ccagagcgcg
     1201 cacggtgtcg tacacgtcgt cgagtttgcc ctgcgggtag cggttgtagc tggagcgcag
     1261 ggtccggtcc cacttgctgt cgaggcgtgc ggcgacccgg gggtcgtcgg cgagtgcgct
     1321 gccggtgatc cccatcatcg aggcattgag gctgatgcag ggaatgacga acatgctcgc
     1381 gtccttgatg agaccgatga tctcgtcggc atgtggctgg tccatgaaca cgtgggcgac
     1441 gccgtcgacg ccggcttcgg cggccattct ggtggcctcc acggtcagcg cgtgagccac
     1501 ggtgagggca ccgtacttct tggcttccgc cacaccggcg ttcacggtgg cctggtcgag
     1561 cgagggcagc ccggggtgtc cctccacgct gccgtcgtca atcatgaact tgatgaagtc
     1621 ggagccccgg gcgaggagtt gggggacgaa ggcggccgct tcctcgggag tcgtggagaa
     1681 cggcatcagg ggcatcaccg gggggaggtc ccacttcggc cggaagcctt cgggcatcag
     1741 ctcgctcggg tggccaccgg gcggggtgat ggcgaagccg gcggaacgca catcggccac
     1801 ggtgtcgtcg tcggtgatga gcccccggtt ctcccgggtg ttcatcccct gcatctccag
     1861 ttcggtcgtc accccgaacc gcagggcgag cgccagggag cccggggcgg agtgaacatg
     1921 ggcgtcaatc agtcccggca gcaaggtggc gccgctgccg tcgacgatct cgctgtccgg
     1981 gggagcatcg ccaccgacgc gagcgatcct tgcgccgtcg atgaccacgg tctgcacgcc
     2041 gagggtcttc tccccgtcga agacccgggc gttggtgatc gcggtgagtg ccatagcagt
     2101 ccgtctcact tcctcgctcg ccatatttac atacctgatg ctatgcactt gcgagaaggt
     2161 atgcaaatgt gcgggcgcgc ctagactcac gtacatgagt agcgcgtctt cctccgagcg
     2221 gacccccgac gacctggtgc tggatcagat cggcccggcg ttgtcacgcc tgcgacgacg
     2281 cgcaccggca tcgagcaagg acctctcccg caatctcgta ctcaacgtga tcgccgatgc
     2341 gccgggcgag acgaccgtcg gtggcctcgc cgccgcgatg ggcgtcgccc agccggtggc
     2401 cagccggacc gtcgccgcct gcatcgagga ggggctgctg cgccgggcgg catcccagtc
     2461 cgacggccgc cgcaccgtgc tcgaactcac cgagcacgga gaagccgaac gcaaccgctt
     2521 cgccgccgag cagcgaaaag cgttccagga gatcaccgcc gcctggcccc cggaggagca
     2581 gatccagttc gcgcgcctct tggtccgata cggcgccgac gccgccgcat ggtccgggaa
     2641 gcaggccacc agccgcgact gaacgagcgg gccccggcat cgggctcacg gccgggcgac
     2701 gaccggggtc ggtcgcggcg cccgacgccg cagcggtctg cgctactcgg cgaggcggtg
     2761 cagccagtcg cgcagcagcg ccgtctcggt gtcacgcaag gggggcgtgg cgccgtcctc
     2821 gacggtcagc gcggcgtcga gtgcgagcgc ccgggatgcc aggtccgcgg cggtggcgac
     2881 gggcgggccg gtggtgatgg acccgatgac gatgttccgc agccgtgtcg aggtcgacag
     2941 attccggtgc ggcgcttctt caccgatcag cgccagggtg gctccggttg tcgcggcgtg
     3001 gaccacgcgg ctcgcctcct ccaccggcac ccgaaggcgc gcgtcggcgg cggctcggtc
     3061 cagcaggccc accagcaggg cgtgcgcctc gtcggcggcc gggggcttgc ggccggggcg
     3121 ggccgttccg tacatgagca ggtagaacgc ggggtgccgc aggccgaagt cgacgtgcag
     3181 gtcccagccc cggtagagat cggccaccgg gtcctcggat cgggacagcg cctcgcgctt
     3241 ctcggccaga tacctctcga atccgtggac ggccagctcg gcgaggagtc cgtccttgtc
     3301 cccgaacatc cggtacagcg tcggtgccgt gatccctgcc gcggcggcga cggcccgcgt
     3361 ggaaaccgcc tcaccgcctc cctcctccag cagttcggct gcgacctgca gaacctggta
     3421 cctggcggcg cgcctgtcct catccatgga acgatgatac gccttcttgc gtatcggcga
     3481 cttatcagcg ttacgataat ctcggatcac cgatcaagac ggccgccgat caagggctgc
     3541 acctgcacgg gcccccaccg gcacaggggt ccagggggct ctcgttccgg ccgcgtaccg
     3601 aatccgccac gcgtgccacc cgagcccgtc ccgcagccct tcgcggcccg ggcggaccgt
     3661 cagcccacct cgccggcatt ccaggacgcc gcgtcagcac tcgccggcgt catgagagga
     3721 aacagccatg tccgacacca cgatcgccat cgcctcgtac tccggctacg gccacacggc
     3781 gcagatcgcc gcggccgtgg ccgacggcgc gcactccgtt tccgggacgc aggtccaccg
     3841 cgtggacgtc gcctccctca gcgatgcgga ctgggaggtg ctggattgcg ccgacgccat
     3901 catcttcggc tcccccacct acatgggcac cgcctccgga gccttccacg ccttcgccga
     3961 agccaccagc aagcgttgga tgacccgcgc ctggagcgac aagctcgccg ccggattcac
     4021 caactccggc tccatgagcg gcgacaagat gcacaccttg cagtacttcg ccgtcctggc
     4081 cgcccagcac ggcatgctct gggtgagcct gggcctgctg ccgggctgga acaccaccac
     4141 ctccggcccc gaggacgaca accggctcgg cttctacctc ggcgccggtg cgcagagttt
     4201 caacgacacc gccgccgtcc acgacgccga cctgagcacc gcgcgccacc tcggccgccg
     4261 cgtcgccgaa cagacccgca tccaccgcga cggcctggcc gcccggcggt gaccccgacg
     4321 cccgcacacc accaccgctc gctccgccct ctgagggcgg ggcgagcggg acgggagagc
     4381 acatgacctc caccaccgag acccccatcc agaggctgct gatcggcggc gcctggcagc
     4441 aggcagcgga caaccggatc tacgcggtgc acgacccgtt caccggccac gtggcctccc
     4501 gcgccgccgc cgctcgcacg gcggacgtcg tgcgcgcagt cgaggcagcc gagcaggcat
     4561 tcggcgcctg ggcggggctg gcacccagcg agcgccgccg caccctgtgg acagcggccg
     4621 agaggctggc agcgcgggcc ggggaactga ccgaggcgat caccgccgag atgggcggcc
     4681 ccgccgcctg gggcgcctac aacgtcaagg tcctcaccga gaagatccgc tacgcggcga
     4741 gcgccgccca cgagggcctg accggccagg tcatcccctc cgaaacctcg gggcgcacct
     4801 cgatcgcgat ccgcaagccg gtcggcgtgg tcgccggcat cattccctgg aacgccccgg
     4861 cgctgctggt gggcgcctcg ctcccggcgg cgctggtact cggcaacacc gtcgtgatga
     4921 aggcgtcgga gcagacaccg cgcacccatg gcctggtcgc cgagtgcttc accgaggccg
     4981 gactgcccga cggggtgctc aacctggtca ccaacgcacc cgaggacgcc cccgacgtcg
     5041 tcgacgcact catcgcccac ccggccgtcc ggcgcgtcca cttcaccggc tccacccggg
     5101 tcggccgcat catcggcgag aaggccgcct cgcatctgaa accggcgatc ctcgaactcg
     5161 gcggcaaggc accggtcatc gtcctcgccg acgccgacct cgaccacgcg gtcagcgcag
     5221 tgggcttcgg cgcgttcgcc aactcgggcc agggctgcct gtcaaccgaa cgcgtcatcg
     5281 tcgaccgcgc cgtcgcggac gagttcaccg ggcgtctcgc cgccctggcc gccaccatca
     5341 cctgcggcga cccgcgtgac ccgcagaccg tgctcggtcc cgtcgtcggc cggaacgccg
     5401 tatcccgcct gaccgacctg atccaggacg cggtcggagc gggcgcacgc ctactggcgg
     5461 gcggaacggc caacggcccg tgcttcgccc cgaccgtgct ggccgatgtc gcaccgggca
     5521 tgcgcgtcta ccgtgaggag tccttcggcc ccatggtcac cgtcggcatc gtcgacggcc
     5581 acgaagaggc cctgcgcgca gccaacgaca acgactacgg cctcacctcg gccatcttca
     5641 cccgggacat ccccctcgcc ctgaacctgg ccaagcgcat caacaccggc atgtgccaca
     5701 tcaacggcgc caccctcgac gacgaaccgc agatcccctt cggcggggtg aagaacagcg
     5761 gctacggcaa gtccggcgga cgggccggac tggaggaatt caccgaactc cagtggatca
     5821 ccatcgaagg cccgcaggcc ccgcgctacc ccatcaccga atgagcactc ggtcctgccg
     5881 gtgcgcggag ttggatcgac aaccccgggc gaccagcgat ctcaccgcgg tgctgtcccg
     5941 tctcatttga tctttgccgg tggcatggtg cctgaaatgg ggtgatgcaa cggaatgtga
     6001 gattgggtgg cctggccggc ctcacatccc gttgtcgctc aggtgggttc gccgccgggt
     6061 gtctcaggtt cgattgccgc tgacccggct ggtggcctga tcgccctgaa ttgcctcgcg
     6121 ctcggcagtg aagtcgtcga gaagctggaa caagaccccg gatacagcca catcacggtc
     6181 gcactgcgcg ctaccgggca ggggaggacg cgaacctcgc tgagcaggcc cggggaaacg
     6241 gaccgagagc cgtatgaagc cgtcgagccg gtcgcccggc tgctggacgc cgcgggggcg
     6301 tgacgggagg tgtgcggggt ggggtacgcg gccggtgcca cacggcaccg gccgggtacg
     6361 cggtgctact tgacgccgac gacgaggtac tccgggccgt ccaggtggct cacggcgatg
     6421 tcccggaagc ccgccgcgcg catccagtcg ccgcactcgg caccggtgta gcccagtccg
     6481 ccggccgaga ccgtggagac gttgaggctg atcagcaggc ccgtggtgcg ttcgcggcgg
     6541 tcgtcgtcga tcagcgactc gtagatcagc agccgaccgc cgtccggcag cgcctcgtac
     6601 gccttgccga tgagggtctt cttggtgtcc aggtcccagt cgtgcaggac gtgtcccatc
     6661 acgatcgcgt cggcggtcgg cagcgggtcg gtgaagaagt cgccgccggc gaagcgcgcc
     6721 cggtcggtga ggccgacccg ttcgaggtgg gcgtcgaagc cggggccgac cacgggcagg
     6781 tcgaagccga tgccctggag gtgtgggttc cgggacagca cctgggccag cagcgagccc
     6841 tcggcgcagc ccacatcggc gaccgtccgc gaccccgacc agtcgtaccg ctccgcgatg
     6901 gcctggttgg cgcccatgct gtagccggtc atcgcccgca ggaatccggt cacctggtcc
     6961 ggggcggcgt acgcctcgcc gaaggtgtcg tccgtggcgt cggcgcccac cagcttcggg
     7021 tcgccggccc cgccctggtc cgcggactgc gaggcggcca gcgccgcgga gaagtccagt
     7081 cggccgccgc tgcgcagcgc gtcggtcagc cccgcccagc agccgaagcc cgcgttgagg
     7141 aaggagaggt agccggagat gtcggtggcg ggcttgcgag ggtccagatg gcagtcggcg
     7201 accggggagt tgcggtagac gccgccgtcg cgctccagca gtcccaggga caccagggcg
     7261 tcgaggaaat cggcggcgcc gcggccggcg atccccagcc tcccggtgag ttcggcgcgg
     7321 gtggcggggc gtatggcaag ctcctcgaac acgcccagtt cgaccgcgct cagcagcgcc
     7381 ttggacttcc agaaggcgac ggcgacgtcg atgatggcgt gcggtgagtc ggccgggaag
     7441 gcgtcctcgg gttgcggggt ggtcatgctc ggttctccgt tcctgtggtg cgggcgtgtg
     7501 cgggcgtttc aaggggcccg ggcatcaggt cagccggagg tcctggtaga cggcgtcacc
     7561 gatggtgatc attcgttcct ggtgctcttc ctgccaggtc ttgccgttga ggtgcagcgc
     7621 gaccaccagg ccggcgtccg ggtcggcgaa ggccgccgag gtccacagcc cgtagtggcc
     7681 gaaggtgcgc ggcgaggcgt ggcggctgaa ggccgtgcac gcgtcgccga ggtggcggga
     7741 ctcgacgcgg aagcccagcc cccagtcggc gttgccgaac gggtccacca ggccgacccg
     7801 gtggtgcgcg gtgagtgcca tgacggtctg cggcagcagg atgcgcccgt ggcgcccccg
     7861 gccgccgtcc gccagcgcgg cgaagaacag cgccaggtcg gacatcggcc cgcggatgtt
     7921 caggccgggg atgggccggg tgcaggatgc ctcggtggcg taccagtggg tgggctgggc
     7981 cgggaggccg ccgccggtga tgtggatgag tggcagccgg tccgcctcgg cgcggtactc
     8041 ctgcggggtg agcaccacgc gggtgtcggt catcccgcag ggcgccagga tctcctcggc
     8101 gagatagcgc tcgtagtcgc gtccgtccac ggcgcggacg acctcggcga tcaggaacca
     8161 cgcccaccac ggcccgtagt tgatccgcgc gccggggggc gtccccgccg ggaccgtcat
     8221 gttccgcagc agctcacggc ggagcgcgac cggggcggcc atggccccgt gcagcgggtc
     8281 caggcccatg gggacggccg aggtgtgggt gagcagctgg tagagggtga cccgttcgcg
     8341 gccgtcgccg tcgtaccagg ggaggtaccg tgcgaccggc gccgccgggt ccagcaggcc
     8401 ccgctcccac agctggccga tcgccaccgc gcccagcgtc ttggagcagc agtaccagat
     8461 gggcagggag gcgcgggtga agggcactcc ggggcggcag ctgcccaggg cggcggagac
     8521 ggtggtgccg ctcgggacgt ggctgacgtg gagctgggca ccgggggtgg tccggccgag
     8581 ttcggcgcgc agggcggcca tcgtacgggg cagcgcctcg gtggcggcgc ggaccgcgtc
     8641 ggcctcggcg tccggcgcgg tgaccgctgc ggcggcgccc ggccacgggc ccgccgcctg
     8701 cggcgcgtcg gcggtgaacc cccgcagccg ggccagcgcc ccggacgggt cctgttgcag
     8761 cagccggtcc aggaagaaga tgaagaggaa caccccttcc aggaccagcc gtccgtgctc
     8821 gaagagccgc acccgccgct cggcgtcccc gaacagcagg acggcggcct cctcgtgccg
     8881 gagggtcagg acgagggtgg gccgttcgtc ccattcgccg gcgcggaacc acagggcgcc
     8941 ggtggccaga tccgtcagga cgaggatctg cccggccacc ccggcaggcg gatcggtcag
     9001 gcgcaggccg agccggaggg cctcgccttc cgcgggccgc tgcccggccg tggcctcggc
     9061 gtgccgcagc cactcccggg agaacagcgg gtgggcggcg ggtgccgccg tacgcgactc
     9121 gtgcggcgct gtgcaggcgg cgctcaccga gcgacctcgg cgacggtgaa gcggacggtg
     9181 ttccggctgg tcaggctccc gtcgggggcg cgcagtccgg ccagctcggc ctcgaccgcc
     9241 ttgaccgcgt cggccatcgc gtcctcgggc acgctctccc agaactgccg gcccgcggtg
     9301 gaccacaccc actgccacca ctggtggggg ccgcggaagc gggtgacaca ggtccgctcc
     9361 acggtgtcga cggagctgaa gccctcctcg gacagcatgg cgtgcaggtc ctcgacggag
     9421 cggaacgggc tgtccggcgg gagccggtgg gaggaggcgc cgccgtaggg ggcactggcg
     9481 gcgaagaccg ggttccagcg ttcgtcctgg cggccccacc aggagatggc gaaccggccg
     9541 ccgtcggcga ggagccggcg gtagcgggcg gccgcggccc tggggtgggg gaagaagaac
     9601 atcgagatcc cggcgagtac cgcgtcgaag gtgccgtcga cgggcggtcc gggctgccag
     9661 tgggcggtct cggcgtcggc gacgagggcg cgggcgttgc ccagcccttc ctccgcgatg
     9721 gccgcgcggg accgctccac catgcccgcg gacaggtcga tgccggtcac cgagccgctc
     9781 ggcccgacgg cccgcgccgc gggaacgagc acggcgccgg tgccgcaccc cacgtccagg
     9841 acccgctcgc cctcccggac gcgggcctcc gccaccaact ggcggccgag ggcgtcgaag
     9901 tgcgagacac cgaccttttc gtacgtcggg gcgctgcggt cgaagagccg ggccagggcc
     9961 tccttgtgct cgtccggcgc cgggtgccga agggtcccgc tcatggggtc ctccccttgt
    10021 cctgtgtgag gttgccgctc tcgtcgagcc gtacggtgcg cccggtgcgg gcggaggtgt
    10081 acacggcgtg caccaccgcc accgcccgcc gtcccgcggc gccgtcgacc aggggtggcc
    10141 ggccggtgcg gaccgcgtcg cagaagtcgg cgagctggtc gcggtggggc tggtggagca
    10201 ggccgatgcg gtcgcgcggc gggggctccg gcggcggcgg gcaccggtcg gcggcctggt
    10261 tgccgtcgcc gtacgcgccg taggcggcgg gccgctcgcc ctcgcgggcg gcgtggaagt
    10321 aggccagttc gtcgttgtcg atgacgaccg atccgcgctc gccgttgacc gcgacccggg
    10381 tggtacgccc cgggtaggcg gcggtggtgg ccagcagcgc gccgagcgcg ccgccggcga
    10441 acttcaggct ggcggtggcc acgtcctcga cctcgatgcc gtcgtgggcg agccggccgg
    10501 tgtgggcggc ggcctccacc acggggccgg ccagccactg ggcgaggtcg acggcgtgca
    10561 cggcctggtt catcagggcg ccgccgccgt ccagggcgcg ggtgccgcgc cactgccccg
    10621 acgcgtagta ggaccgcgcc cgccacaggg gaacctcgat gaggaccgag gtgatccggc
    10681 ccagggtgcc gtcctcgatg gcggccctgg ccacttcggc ggcggggtcg aagcggtgct
    10741 gggagatgac gccgagggtg cggccggtgt gccgggcggc gtcgatcagc cggtcggcgg
    10801 cctccagggt gacgtcgatg ggcttttcga ccaggacgtg cttgcccgcg cgcagggctg
    10861 cggtacccag ttcggcgtgg gtgccggagg gagtgcacac ggcgacggcg tcgatgtccg
    10921 tgcgggccag cagctcgggg acggcgagtg cctcgcagcc cagttcggcg gcgagccggt
    10981 gtgcctgtac cgcgtcctgt tcggcgaccg ccaccagagt ggcccgctca cgcagtgtgc
    11041 cgtcgggcca ggccagcaag cggccgagga agccaccgat cgagccgcag ccgaggatgc
    11101 cgaagcgcag cacggcgcct cctcagcccg tcaccggggc gatggcgttg cccaggtagt
    11161 tggggagttc ggtgagccgc tgctgctggt ggtccaggtc ggtggggtag gcggcgcggt
    11221 agcggcgggt gacctcctgg acctcgcgcc aggtggcggg ctgcaccccg ccgttgtact
    11281 ggggcgcgag ctggtcgtag agggtggtgc cgggccgcag atagagctgg ttgatgccga
    11341 accaggcggg cagcttcgcg gcccagtcga ccaggcgtcc ggagatgcac gcctggtcct
    11401 gcggcagccc cagcaggacg aaggcgaagg gggtgatgcc ggcgtcccgc agtttgagga
    11461 cggcctcctc gatctgtgcc tcgctgaccc gcttgtggac gccggtgtcg gcgatggcgg
    11521 gcgattcggc gcccagccac atgccctggc agccggcccg cgcccaggcg gtgacgtcgt
    11581 tcttgaggac gacctcggcg cgggtctggc cgacccagcc caccccgcgg ccctccagcc
    11641 gggcgcacag ctcgccgtag aaggtgcggt tgatgccgaa gacgtagtcg aggaagaaca
    11701 cgaactccag gcccgcggcc tgctgggcgt cgatctcgcg caccacccgg tccagcggct
    11761 ggttgcgcat cttggtgccg aacggcaggt ggcagaaggt gcagccgtag gtgcagccgc
    11821 gggcggcgag caccatgccg caggggccgg gcagcggcag cccaccggag atgacctcgg
    11881 ccgtgtagtc ggcggtgggc accaggtcgt aggcggggaa ggcgagttcc tccaggggga
    11941 ggttggggaa gggacggggg cggggctcgg gtgagtccag caggttgtgc ggggtggcgg
    12001 cgcccgggag cacgggtgcg tcggcgccgg ccagcagggc gcggaccgcg ccgacggtgg
    12061 ccgaatcggt ctcgccgcag gcgatgtggt ccacgcccag ctcggcgcgg gtggaggcgg
    12121 gcaggtgggt gccgtgcggg ccgaccgcga cggtgcgggc cgtggggtag cgggacgcgg
    12181 cgcgctcgac ggcggcccgt acggagtcca gctccagcgg gtaacactgg gcgcggtcgg
    12241 cgatcgcgga gaagacgacc agcaggtcgc actcctcacc gtcgggcgcc tcctggagcc
    12301 gctggtccca cacggtgacg gtgtggccct ccgccctcag ttggccggcg gcggtgacgg
    12361 cgtccagggg gagctggatg aagtactggt cgaacttgtt gctggggatg acgaggcaga
    12421 tccggctcat gggcagttca ctctcacagt cgggtcggca gggcggcggg ggtcgggggg
    12481 ctggagggcg cggggcgttc ggtgcgggcc agttcggcca gccggccgat gcggtcgagg
    12541 gaccgcaggt ccagcgcggg gcgcggacct gggccgagca gggccgcgat gccgtgccgc
    12601 agcgcgttgt ccatcggaga gtcggggatc agccactctc ggtgaccgtg cggcccgtcc
    12661 atggtcagcc ggtgggtgtt gcggggcagc cgggtgccgt tgggcaggaa gaccgggtcg
    12721 agttccaggg tgaggaggac cggtccggcc tcgatccggg ccagccgcag ccggctgtcg
    12781 gcggcgggtg cggtgcgccg ggcccaggag ggcgcggggg ccgcgtgcgg ggcgtcgggg
    12841 ccgacgatgg tggagtacag ctcgacctcg acctcgcccg cgaggccggc acccgcgctc
    12901 agtgtcgtgg tgtcgtgggc cgcggtgctg accaggtggg ggtcacgggc gatccgtacg
    12961 gcctgtggct cgggcccggc cagcagatag tggtcgaagg cccgggcggg caggaagccg
    13021 ccgaggacgg cgagcatgtg cagccactcg tagccgaaga cgccgtagtc gaggtcgacg
    13081 aagcggccgg ccgcgatgtc ctcgcggcgg tccttgcaga aggcgacgcg gatggccgcc
    13141 accgggtgcc ggggggcgaa ttcggcgcgt acggcctcaa gtatggcggg ggccttggcg
    13201 tgcgcgtact ggttcatcac caccagccgg gcccggtcgt acgcgccgag cagcgcggtg
    13261 agttcggggc cctcccagga ccggcaggcc ggcttctcca gcaggatgcg ggcctcgggg
    13321 tcgcgggcga ggacggcggt cacggtctgt acatggccgg cggtcggggt gcagaccgac
    13381 cagacgtcca ccggccggtc cgtggacagt tcccccacgg tggcggcggt gggtaagggg
    13441 gtgccgcagc cgggggcggt ggggtcgacg acggacacgg atatgcccat ggcgtccagc
    13501 agttggcggt gcagccggcc ggccacgccg tggccgacga cgcacacatg cggcctaccg
    13561 ggcatgggcg tcctcaccgg aggtctcagc ggtgccggcg aacgctccgg tgcccagcgg
    13621 ggcggaccgc gcgcacaggt actgggtgta gtacgcgtcg aacagcccgg cgtcgtcgat
    13681 gatccggtcc accggctcca ggtggaggcc gggcgggaac cgctccggat cgcggcagag
    13741 ggcgagcgcg gcgagcaggg tgccggcgcg gtaggcgtcg tagccgcggt tggcgatgcc
    13801 ctcgtactcg aagaggttca gcgagcggcc gtcgcccagc acggtggcgg tggtggcgtg
    13861 cggcaggtcg tagcgcacgc cgacgtgcgg gatgcgctgc gcggtggcac cggggtagcc
    13921 gtcggtcagc acgctgaagt ccttggtggc gaagccggcc agcagcacgc cgtcgggcag
    13981 cagcggcacg tcctcggcgg tgacggcggt gccgccgctg ctgccgagga tgaggaacgg
    14041 ccgctgccgg tcgagggcct cggcgatgct gcggtgggtc tcgaagccgt cctcggcggc
    14101 ggtgatcagc gccaggatgt cggtgtccac cacggcgacc cggcagccca gcgcccgcag
    14161 cgagcgggcc gcccgtgcgc ccagggtgcc gtagcccagc agcaggacgt gccggccgat
    14221 gaatttctgg ccgggcacga tcgcccgcag ccggcgcacg caggagtcgg cgatctcgtt
    14281 gtagcccagc cgtgacttca gctgggagcg ggccatgttc agtacgggga cggccagttc
    14341 gccgggggcg gccgtgatgc gcttgagccc gctgaccgtc agttcgatgg cggcgtccac
    14401 ccgcggtccc ggtccgtcgg cgccgtagcc ctgggcgagc aggccgccgt cgtcgatgac
    14461 caggaccttg cggccggcgg cgtgcgcccg gcggacgaag tcggccacct gggcgtccac
    14521 cgcccgtgcg cgggccgctt ccgccgctcc ggccgtgccg ttgatgacgg agttgtccag
    14581 ggtgtcgctg gcgtagccgc ggcgcaggaa ccaggagtgc actcgctcgc ggtgctgcgt
    14641 ccggtcgccc ttggacagcg cgaagatcca ctcggggtcg agtccggcgc gctccatggc
    14701 cagcaggaag ccgacgctgt tctccacata gtggtcccgg aagatcaacg cccatccggc
    14761 gagcgccggt tcgggccggg catagcggtc cgtcagcggc atgccggccg cgatggcggc
    14821 ggcctcggcc gcggtgtagc accgggcccg ccggccgatc gcctcggtca gcgcggtgaa
    14881 caggtcgcgg gcccgctccg agggggcgcc ggaggcggtg agcacgatcc ggcgggcccc
    14941 cggcccgtcg aggacggggt ccagggtgcc gggcggctgg tcggacagcg gccggctgcg
    15001 gatgtccagc cggtcgccgc ccacccgcac cgtgtactgg ccgggcccgt gcacggtcag
    15061 ctcgggtcgc gccggcgccc cgccgtggcc gtcgaggacc gcgcgcacgg ccgccagcag
    15121 gtcaccggcg ccgagcgggc cctccagcac ttcgcacggg cccggcggat gaggatcccc
    15181 cactcccccg ccggggacgg tgcgacgcga agtaacatca gataccgaca tatatccacc
    15241 cacgccaggc gtgcattcct cgtgagaacg gacttgctgc ggctgggccg gaaccaggag
    15301 gcgctcctgg tccggctggt gttctcaggt cagcctgccg tgcgggggat cttgacggcc
    15361 atcgtggaga tccacgatcc cggtggtcgc ccggcgcggg cgacggccct ggtcagccgg
    15421 atgcgatgag gctccgcgcg ccggaggagg ccgccgcgcc cgccccggtc agccgggagg
    15481 cgagctgggt gcggcgggtc acgccgagtt tgcggtaggc gtgggtgagg tgggtctcca
    15541 cggtgcggcg ggccaggtgg agcacctcgc cgatctgggc gttcgtctgg ccctgggccg
    15601 ccagctcgac gatgcgccgc tccgcccggg tgagtgcggc gctgcccgtg gtgtcccggc
    15661 gggtcccgcg ggcgccgctg gcccgcaggg cgttaccggt ggcgcggagc aggcgtccgg
    15721 tggcgggcgc gtccggggcg tccgggtgtc cggtgggatc gggggccagc aggcgcagtg
    15781 ccagggcgtg ggcctcgtgc aggtcctcgc ggcccttgcg gctgttcccg gcgtcgatcc
    15841 gcgcgcggcc caggtcgagg agggtctcga cgagttcgac gggggccggt gcggtcctca
    15901 gcacggccac ggcctcgctc agcgattcga gcccccggcg gccgcccacg gccgcggcac
    15961 gggcccgcag ggcccggctg accgtgcggg gtgtccccca ggtccgcgcg tggcgcagtt
    16021 cctcctcggc gaggtccagg gctctcgccg gctgtccgag tccgaccagg gcgagggcgg
    16081 caccggagcg ccagggggtg gccacagggc tgacgaagtc gcgggcactc tggccgcggc
    16141 cgcaggacag gtagtcgtcg agggcggcct gccagttgcc ctcggccatg tgcagaaagg
    16201 ctctggcgca gtgcagttcg ttccattccc aggagctgcc ggcgctctcc tcgtcgaggc
    16261 cggccagcag ccgccgggcg tgggcacggt tgccgagttc gcagtgggcg agtgccacca
    16321 tggacaccag gtggggcatg cggatcccct gcccggcgca cgcgtcgagg agcggggcgt
    16381 tctcggcgat cacgcgccgg aagtcaccgg cccacagggc cgcttcggcc cgtacgctga
    16441 tcaggcactg tcggccgatg tccgtcagat ccgggagcgc gggcgaggcg gggagggcct
    16501 cttcggcgag ggcgcgtgcc tcgtccagcc ggtcggccca ctgcagcaag gtggccgcgg
    16561 ttcccagcca gccgtcgcgg agccgggggt ccaccggtgc ggccagccgc ggcagcacac
    16621 ggccgagggc ctcggccgcc gacagccggc cggtcccgac ctcgtactcg gtgaccaggc
    16681 cgtaggcgag cggctcgacg gcggcggggg ccgtcgccgc cagttcccgc atgcgggcga
    16741 cggcgttgcg ccacgcgacc gcgtcgtggg aggccatgac ggcggcggtg gtctgcagca
    16801 cgcggtcgag ctcgccgtcg tccacggcgc tgcccacttg gctcatgacg cgcatggcgg
    16861 tgtccgtgcg gccccgggcg acgagcgccg cgccgagggc gggtgcgaca gcggcgcgtt
    16921 catgacggtc ggcgtgcagc tccagcgccg cgcgcagcct gcggatgccg gcatccgcgc
    16981 tgtggggcag ctccagggcg ccgaggcgca gggtgagccc ggcgcggcgg gcgggggcga
    17041 gcggagcggt gagggcgtgg cggaggaatg cggtggcctc gtcgacccgg ccgccgcgta
    17101 cggcgtcctc ggccgcgtcc tccagggact gcgtcatcca ctcctcgccg ggccggtcga
    17161 ggtggagcag ctgggcggcg acgtccgccg tgggcgcgcc gcgctcgtcg agcaggcggg
    17221 cgatacggcc gcgcagcgcg cccagttcgg ccggatcggc cgccgccagg gcggcctcgc
    17281 gtgccagcgg gtgggcgaag aggcggcgga gggcggacgc gcccgcggac gcggcgcggt
    17341 ggtccgggca gaggccggcg gcctcgtgga gcagggcccc gccgagcagc gcggcgccgt
    17401 tcccggccac ggcgagcgcc agggagaggc ggcgcgacca cggggtcgcc cgggtccgta
    17461 tccaatggac gatcgcgtcg cggtagcggc ttccgccgag ctcggacagg ctgcggggca
    17521 gtggcccctc acggaggtcg gcgaggaggg cgtgcaccag caccggattg ccggcgcacg
    17581 cccggataca caactcggcc cggtcggcgc cgtgtccgcg ggcggacacc agacgggcca
    17641 cggcctccgg gcccagcggg cggagcacca cggccgtgcc cgtcgcaccg ggcagcacgg
    17701 cggtgccctt ctcccggcac tcggtcagga ccagcagcac gggcaggtcc gccagccgac
    17761 gggccaggta gccgagccag cggcgtgacg ccatgtcggc atcgtgcagg tcgtcgacgg
    17821 ccagaagtaa ggaccggcgg tcggcggtcc gcgccaagcg ggtcacaagg cggtggaaga
    17881 ccatctgctc ctcggccgcc ggcaggtccg cgaagggcac ctccccgtcc tcgggaaaga
    17941 gctggcgcac gagagcgaag gggaaccccg actcctccgg cgaacagtcc gcgcgcagca
    18001 cgcacatcgc cccgcccgcc gcctcccgct ccgtcacctc ccgcaacagg gcggtgcggc
    18061 ccgtccccgc cgccgcaccg aacaccagcc aacggcccgc accggaccgc gcggactctc
    18121 cggctctcgc cgcggccgcc agcgcttcct cgcgttcgag aagcacactg cccataccca
    18181 cactcctcca tctcggtgca cacgacgccc ctcggtgcaa ggcgcccgag atgaatactg
    18241 catgccgaaa gtcgcgaaat cccctattcc gggccagcgt tctctccgag ggatatcccg
    18301 catggcctgg ccggacacgt gatggtcttg atgtgggtga cgtggcgtcg ggaccgggcc
    18361 gggtggtaca tcgcggcgac cgcacggtgc ctattgaggc ggttgacacc gcactcgacg
    18421 gagcgtctct gcctgcggac cgtcttgccg caggccggca ggcggccacc ggcggagccg
    18481 cggttcttgc ggttgcggag ctggtcggtc cgctccggct tcggagcccg ctgcatcagt
    18541 gccgcggcgg cttcggcgag cgtagctttc tcgtgcagca gcacgtacat cacttccgtg
    18601 atcggcatgg tgatgtcgta agcgcgggcg cgatcgagga gtgctcccgc agtcttgacg
    18661 ccctcggtgg tctgccgggt cgaggcagcg gcctcggcga cgctcatgac ctggccaagg
    18721 tgagtgccga aaaatgttcc tcgcgctcag catgtctcat gggacatccg gcgcgaagcg
    18781 agcaaggtgt ctggcctgga gcttagtggt cggctctgga agtccttcgg aggccgactc
    18841 cggagccagg gccatgcgtg ccggcgcgcc aggcgcccgc gggtggggtc gacgtccgag
    18901 tcggattctt gccagaaggc gggcagcagc cgatgtttga ttgtgcgcat gaccatcgcg
    18961 caaccggaca acgcccgcct cttccgctcc ctgcacaccc ccactgaacc tctcgcgctc
    19021 gccaacgcct gggacgttgc gagcgcccgc gtcatcgaag ccgcgggcgc cgccgcgatc
    19081 gccacgacca gtgccggcgt cgcctggtca ctgggttctc cagacggcga catcctttcc
    19141 cgggaccggg cgctggagct gatcggccga atcgtcgccg ccgtcgcggt tccggtcacc
    19201 gccgatatcg agggcgggta cgggacggat gccgccggcg ttgccgagac cgtggccggg
    19261 gtgctcgcgg cgggcgccgt cggcgtcaac atcgaggacg gcacccgacc cccgacggag
    19321 ctcgcaacac ggctggctac ggcccggcag accgccgacc gggcaggcgc ggacctgttc
    19381 ctcaacgccc gaatcgacac cttcctgtcc gggctcggtg ccccggacgc ccgcctgaag
    19441 gaaaccttgt cccgggcccg catgtacgtc gatgcgggcg cggacggcat cttcgtcccc
    19501 ggcgtcaccg acaccgccac catcgacgca ctggccaggg gcatctccgt accgctgaac
    19561 gtcatggccg gccccggcac cccgaccgtt gccgagctcg gtgtcctcgg cgtggcccgc
    19621 gtcagtctcg gatcgggcgt ggcacaggtc gcctacgctg ccgcccgccg cgccgcgcag
    19681 gatctcttcg gcaccggcgg ctacgactcc ctcacccaag gcatggcctt cccggagctc
    19741 aacgcgctgc tctccgaccc ccactgaccc tggtcgagtc gggcggcgcg gccagggcgg
    19801 tcatcctgcc cgcgccatcg gtcaggatgg ccgccctcgt ccgccgtctg cgccatcggc
    19861 cgctccgcta ccgccggtcc acgtccgaca cgggtccgtg gctgcgcgtt tcggtcaggc
    19921 cctgccatcg ctccgcgatg tccgcggtgc cctcggggag gtcgaactgg tcgaggatcc
    19981 gcatgacgat gtggtccacg aggtcgctga tgccgttcgg gatgtcgtag aaggccggca
    20041 tcggggggac gatgcgggct cccatacggg agagggcgag catgttctcc agatggatct
    20101 cgttgagcgg cgtctcccgc ggcacgagga ccagcgggcg gcgttccttg agggtgacgt
    20161 cggccgcgcg ggcgatgagg ttgtcggcca agccgtgccg taccgccgcg agcgtcttca
    20221 tactgcacgg gacgatggcc atgcccgcga ccgggaagga gccggaggag atcgtggcgc
    20281 ccagatcgcc gaacttatgt gtcacatcgg tgagttcggc gcagtggcgg ctgctgtagg
    20341 gcgtctccac ctcgatggtg gagcgggccc aggtgctcag tacgagatgg gtctccacgt
    20401 gcggcacctc ccgcaggatt tccagcaggc ggacagcgag cggggccccg gtggcaccgg
    20461 tgactccgat gatgaggcgg gtgggggaag cggtggtcac ggcgggctcc tgatacggcg
    20521 gggagaggac gggccggtgg gaggggcgca ccgcccctcc ctcgcggtgt cgggctacat
    20581 cgtcaggacg cctgcccagc gcttgcgcag ctcggtgcgg gtcgtctcgt cgacgcggtt
    20641 ggctgccggg tactggtcct tccaggcgaa cggtttggtc gcgtcgatca gcacgatgcc
    20701 catcgacagg tcgccggcgg cgcgtttgcc gggcgacagc cgtgggtcga tggcggtggt
    20761 gggtgtgcgc agcacctgga gggattcgga cggatcgacg cgggtgaaca tcgcccacag
    20821 gacgtggtgg atgtcggtga tgtcgatgtc ctcgtcgacg acgacgaagt accgttccat
    20881 gccgccggtg cgtttgcggc cggcggccgc gagcagggcg tgcatggcgt cgcccgcgcc
    20941 ggtctgttcg atggagacga ccatcatgag ctggcgggcg taggcccaca cgcctttgat
    21001 gttctggacg ccggatgctt ccaggtggtc ccaggtcact gatgccgagt acagcgggac
    21061 ggcttggtcg ccggccggca cggtcgggag cattggcggg gcgccgagga tgatcgggtt
    21121 gtttcggtgc atgatccggt tgacccggac cacggtttcc tggccggagt gggtgtagta
    21181 gccggtccat tcgccgaagg gcccctccag cacggactct tcctcgaccg ggggcagttc
    21241 gccttggatc acggtctccg cgtaggccgg tatcgggagg tcgctgcctg gtgcgtacag
    21301 gacctcgacg ccctgtccgc ggagtccgcc ggcgaggtcg tactccgaca tgccggacgg
    21361 tgcggcgatc gccgcggcgg tcgacaggat cgggtcctgg cccaccacca ccgcgatcgg
    21421 gcaggtcagg ccgcgcttcc agtacttctc ggcgatcgcc ttggcgtgcc ggttgccgag
    21481 catccacagc gagagccggt cggggccctg gacgcaggcc cggtaggtgc cgacgttgac
    21541 ccagccgttg tcggggtcgc gggtgatgac catgcaggcg gtgccgatgt agcggccgcc
    21601 gtccccgtcg tgccaccgcg gcgtggggaa gacgccgaga tccacatcgc cgccgaccag
    21661 gacgttctcc aggaccgggc cagtggggac caccaccggg gggacgggtt cgagctgctt
    21721 gctcaggtcc ttccaggccc gcacgatgtc gagcttcgga gtgtcgcgcg gcagtcccag
    21781 cgccactgcg gtacgggcgg cggtgcccat gaagttggtg aacacgcggt gccccgccgg
    21841 gtagccggga atgttgtcga acatcagggc gggaccttcc ctctccgcca tcagttcagt
    21901 gatgccgccg atgtccaggt cccggtcagc gccatcgatc cgcaggacct cgtcctcccc
    21961 gagcgtctcg gtcatgtggt cgatgtagtg ccgaaggtca cggaatgcgt tcatatgtcg
    22021 tcggagaggc cgggcagtac gtccgtgcct cccgtcctcc tcttcttctc tttgctgact
    22081 gcggcggctg cgcctggagc ggatgcccgc gggggcggtc accgggcggg cttgcgtcgt
    22141 caggatccgg accggccggg aggggtgcaa cgagtccgga cgcagatgcc ggttattacg
    22201 cgagataggc ttgggaggcg tggaatacct cgatctccag ctcattcatg cactacagat
    22261 cgatggccgt gcaccactgc gccggattgc ctcagtgctg ggcgtctccg accagatggc
    22321 agcccgccgc tacgcccggc tgcgggagca ggccgggctc cgggtcatcg gccggctcaa
    22381 tccccggccc gtcgggcaga ccgtgtgggc actgcggctc cagtgcatcc ccagcgccgc
    22441 gctcggcctg gcccacgcac tggccgagcg cgaggacacc cgatgggtcc aactcgcctc
    22501 cggcggaacc gagatcatct gccacctcgc agtgcacagc gacagcgacc gggacgcgct
    22561 gctgatggac aggctcccgt cgagccgccg ggtcacctcg atcaccgcgc accgcatgct
    22621 gcggctgttc aagggcggcc cgaccacctg ggacggtcct acttccgcac tgagccggga
    22681 acaaatggac gccctcgcac cctcgtaccc gctcccccac gcccaggcgg cgccggtgga
    22741 actcacggag ctcgaccacg tcctgctcgc cgcgctgaac cgcgacggcc gcgcgtccca
    22801 cgccgcactg gccgccgtgg cccgctgtca cgagtcgacg gtgcgccgcc gcattgcgca
    22861 cctgcgcacg gccggagcac tcttcttcgt cctggacctg gacgggcgcc tgctgggtga
    22921 cccgtccggc accgccatct ggatgtcggt gcagccctcg cagcttgctg ccgccggcgc
    22981 cgcgctggca ggccaccctg aagtggccta cgccgccgcc actacggggc ggaccaacct
    23041 cctggccaat gtcctctgct ccgacgacga gtccctctac gcgtacctct ccgaccgcat
    23101 cggcgctctc ccgggtgtcg acacggtcga gaccgcacca atcatccgca ccctcaaacg
    23161 cgacggctcc gtcgcacgca acagctcgac actccgtagt gcgccgtgag gcacggggcc
    23221 cctaggtcac cgccctgttc acggagtggt ccggctctcg ttcggttcaa ctcgtcgcgt
    23281 cgtgctcgtg gagggcgatg cggaggcgct cacggacgat gccgtgtccg gggagaccag
    23341 ggaccttttc gcggagcggg ccgggtgcga tccccgcgaa ctgcccatcc cgtacaagca
    23401 cttcagggtc cggcaaccgc gcgtgcaggc gtggcgggag gagaacgagc tgccggggcg
    23461 ggagctcatg cgggacggcg tgtgggcgca ccgaccgccg aagccgtgcc tccgcccacg
    23521 gctgcggtgg gcggaggcac ggcttcggcg cgtcaggcgg aggtggcgac tcggcggtcg
    23581 gccgcggtct tcggggcgtc ggtgacgttg tgctcctcgc cgagcggctt gtcgacccaa
    23641 caggcgaact ccaggaggat tccgtccggg tcctggaagt agcaggaccg gacgtagacc
    23701 cccttctgca tccggggagc gacggtcgag gcactgttgt cgtggttcat gacgggactg
    23761 accgtcacgc ccttggccgt gagccgggcg tggtactcct cgaaccgctc cgccggcaca
    23821 tggaaggcga cgtggttcat cgaaccgacc gcgctgacga actcccccgt gccgggcagg
    23881 ctcttcggag cggaaattcc cggcacgccg tcgggcgcgt ccgcgaacca gaagaacgcc
    23941 acggcgtcac cgccaccgca gtcgaagaag aagtgctgcc ccacaccgcc gggaagctcg
    24001 atcgtcttga tgagcggcat gcccagcacg cccgagtaga agtcgacggt tcgctgcatg
    24061 tccgagcaga cgagcgccag atggttgatg cccccgagct cgaactcact gttcttggac
    24121 gtcatctctc caggacctcc cgttgatatc agccgcgaac gacccggacc ggaagccgaa
    24181 cgcagcacgg cgaatacggt ggcaagtctg acatccggac cggcggtcag cctgccggcc
    24241 ctcgcgatgc gggcagtccc ggccggagcc gagcaacatc cgctcatcgc accgcacgtg
    24301 accgcactgc cgacgctcgg gcagaagggc gaccggtcat gaagccgaga gccgcccctg
    24361 ggcggtacgg ttggccgctt ctggtgcaag gctgctggaa gcatcggttt tgctgcggtt
    24421 cgccggtggt gcggctggcc ggccggccgg ccggccggcc tcagcgtggt gcgaaatacc
    24481 ggccgatgag tacctggtgc gaagccacct gggcgagttc cgtaccgcat gccacagtgg
    24541 gcgccatgac ggcgacggaa gcgacgaacg tagcggcaga cgaggtcgaa gcgctgacag
    24601 cggacgcgct gcgctggctg ctcaagagcg cgcggaaaac cgggaacaac ggcctcgcct
    24661 ggaccatcaa gccctccgac aacgagccca accccacgct ctacagcggc acggccggtg
    24721 tcatccccgt cctcctggag gcatggcggc acttcggcga cgaccggtac ggggacgccg
    24781 ccctgcgcgc cgcccgcagc gtgtccgccg ccgttgtcga cggccggcaa gacaactccc
    24841 tgtacttcgg cctgacaggc atggcgctcg cattgagggc ggtccacgac gaactcggcg
    24901 cagcggatgc cgctgccgcc gcggatcgga ccctggccct ggtgcgggca cgcttcgatg
    24961 ggacacgctg gggcagctgg ttcgatctga tgggtggcaa cgccggcatc ggcctcggtg
    25021 cgctggcggt gggcgatacc gacctggctg tcctcgcggt ggagccctac ctgcgctcgg
    25081 ccgagcagac tccggtaggc gtccactggg aagcgcaaac gggcagagct gctcggtttc
    25141 accacatctc
//
