LOCUS       NZ_CP016353            22556 bp    DNA     circular CON 03-MAY-2024
DEFINITION  Prauserella marina strain DSM 45268 chromosome, complete genome.
ACCESSION   NZ_CP016353
VERSION     NZ_CP016353.1
KEYWORDS    RefSeq.
SOURCE      Prauserella marina
  ORGANISM  Prauserella marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Prauserella.
REFERENCE   1  (bases 1 to 6851918)
  AUTHORS   Ruckert,C., Albersmeier,A., Jiang,C.-L., Jiang,Y., Kalinowski,J.,
            Winkler,A. and Zotchev,S.B.
  TITLE     Complete genome sequence of Prauserella marina DSM 45268, isolated
            from ocean sediment of the South China Sea
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6851918)
  AUTHORS   Ruckert,C., Albersmeier,A., Jiang,C.-L., Jiang,Y., Kalinowski,J.,
            Winkler,A. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 33.7x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002240355.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:59:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,595
            CDSs (total)                      :: 6,536
            Genes (coding)                    :: 6,497
            CDSs (with protein)               :: 6,497
            Genes (RNA)                       :: 59
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 14 of 39
            Pseudo Genes (incomplete)         :: 31 of 39
            Pseudo Genes (internal stop)      :: 1 of 39
            Pseudo Genes (multiple problems)  :: 6 of 39
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:50:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6502034
            Orig. end                         :: 6524590
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP016353.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22556
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="21"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22556
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22556
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12556](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12556)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(129..142)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            complement(161..1288)
                     /locus_tag="BAY61_RS30180"
                     /old_locus_tag="BAY61_29995"
     CDS             complement(161..1288)
                     /EC_number="2.3.1.12"
                     /NRPS_PKS="Domain: Abhydrolase_1 (138-360). E-value:
                     9.5e-34. Score: 109.0. Matches aSDomain:
                     nrpspksdomains_BAY61_RS30180_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156746.1"
                     /locus_tag="BAY61_RS30180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_29995"
                     /product="acetoin dehydrogenase dihydrolipoyllysine-residue
                     acetyltransferase subunit"
                     /protein_id="WP_245865571.1"
                     /sec_met_domain="PF00561 (E-value: 2.4e-24, bitscore: 84.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.9e-25, bitscore:
                     87.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAVSMDDVIRKVVMPKWGLSMTSGKVTEWVAEEGAEVADGDDLA
                     EIDTDKIAGALESADEGVLRRIIARVGEDVPVGGTIALIAPAEVPESDIDEAARTAREE
                     LDSGAVEEVAGPVTGTFDVDGGSIAYATLGEGSEPVVLVHGYGGDKNSWLFVQEPLSRD
                     RAVHAIDLPGHGESGKDVGDGSLAVLARAVLGFLEAAGIEKAHLVGHSLGGAVITAAAA
                     TEPERVASLTLVAPAGIGTGINADYLRGFAAATSRRELKPHLGALFADPALATRQLADD
                     LMKYKRIDGVDKALNSLLANLLDGERQGIDITATLSEVEVPVGIVWGSQDAIIPPANVG
                     DRPDVTVVEDAGHMVHMEQPGAVVAAIGLLVTPRR"
     aSDomain        complement(209..874)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BAY61_RS30180_Abhydrolase_1.1"
                     /evalue="9.50E-34"
                     /label="BAY61_RS30180_Abhydrolase_1.1"
                     /locus_tag="BAY61_RS30180"
                     /protein_end="360"
                     /protein_start="138"
                     /score="109.0"
                     /tool="antismash"
                     /translation="PVVLVHGYGGDKNSWLFVQEPLSRDRAVHAIDLPGHGESGKDVGD
                     GSLAVLARAVLGFLEAAGIEKAHLVGHSLGGAVITAAAATEPERVASLTLVAPAGIGTG
                     INADYLRGFAAATSRRELKPHLGALFADPALATRQLADDLMKYKRIDGVDKALNSLLAN
                     LLDGERQGIDITATLSEVEVPVGIVWGSQDAIIPPANVGDRPDVTVVEDAGHMVHMEQP
                     "
     CDS_motif       complement(641..673)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BAY61_RS30180_0001"
                     /evalue="6.50E-04"
                     /label="NRPS-te1"
                     /locus_tag="BAY61_RS30180"
                     /protein_end="216"
                     /protein_start="205"
                     /score="12.3"
                     /tool="antismash"
                     /translation="HLVGHSLGGAV"
     gene            complement(1276..2289)
                     /locus_tag="BAY61_RS30185"
                     /old_locus_tag="BAY61_30000"
     CDS             complement(1276..2289)
                     /EC_number="1.2.4.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949818.1"
                     /locus_tag="BAY61_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30000"
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="WP_091805540.1"
                     /transl_table=11
                     /translation="MARTISYREAIGEALAQEMERDESVIVMGEDNAGGAGGPGDEDAW
                     GGVLGVTKGLFHRFPGRVLDTPISESAFVGAAVGAATSGMRPVAELMFIDFMGVCFDQI
                     FNQAAKFRYMFGGKAKTPVVIRTMYGAGLRAAAQHSQALYSIFTHIPGLKVVVPSSPYE
                     AKGLMIQSIRDDDPVIFCEHKAMYDVTGEVSEDSYSIPFGEANVVRDGCDVTVVAIGRM
                     VSVAEEAAKTLADSGIEAEIIDPRTTSPLDTETILESVENTGRLVVVDEATPRCNMATD
                     VSALVAKEAFGSLRAPIELVTAPHTPVPFADSLEDLYIPDAQRVTNAVKSVVEWKR"
     misc_feature    2284..2294
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(2303..3307)
                     /locus_tag="BAY61_RS30190"
                     /old_locus_tag="BAY61_30005"
     CDS             complement(2303..3307)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156748.1"
                     /locus_tag="BAY61_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30005"
                     /product="thiamine pyrophosphate-dependent dehydrogenase E1
                     component subunit alpha"
                     /protein_id="WP_091805543.1"
                     /transl_table=11
                     /translation="MTDTLSDKSTSPHGELGESALLDAYRTMRTIRNFEERLHAEFATG
                     EIAGFVHLYAGEEASATGVCMHLDERDTIASTHRGHGHCIAKGVDVKAMMAEIYGRTTG
                     SCHGKGGSMHIADLSKGMLGANGIVGGGPPLICGTALAAKKQGTGGVGVAFFGDGASNQ
                     GTTLEALNLASVWNLPAIFVAENNGYAEATASTWSVAADNIADRAAGFGMPGVIVDGFD
                     FFAVHEAVGEAIERARAGGGPTLVEVKFTRYFGHFEGDQQTYRADEVAKARENLDCLKR
                     FRKRVTETGLLKESALDEVDSSVAELIDVAVDEAKAAPKPGTADLETDVYITY"
     gene            complement(3330..4397)
                     /locus_tag="BAY61_RS30195"
                     /old_locus_tag="BAY61_30010"
     CDS             complement(3330..4397)
                     /GO_function="GO:0003951 - NAD+ kinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006741 - NADP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004563016.1"
                     /locus_tag="BAY61_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30010"
                     /product="NAD(+)/NADH kinase"
                     /protein_id="WP_245865572.1"
                     /transl_table=11
                     /translation="MGARPVTVGVVANPASGRDIRRLVAQASVFPTAEKANMVRRLLSA
                     FASVGVGRALLSTDLGGISAAVLRALRTRRPEREGPWPLVEFCDEDPLTGTADDTTNAV
                     TRMVAAGAELIVCLGGDGTARVAAGACGDVPLLALSTGTNNAFPKMHEATVAGLAGGLV
                     ATGAITTGIRRAGLLEVTAGDRTEPALVDVCTSTARHVASRALWDPTLLAELFCTFAEP
                     DGIGLSSVAGQLCPSPRDEPTGVALTFAPPEEAAWVVHAPIAPGLVVPVGVRSWRRLPV
                     GERVAIGVPHGVIAVDGERELELSGDTAATVRLSEEGPRCVDVAAVLAEAARTGSLRTE
                     QSQSHRRLGEELSAL"
     gene            complement(4686..5633)
                     /locus_tag="BAY61_RS30200"
                     /old_locus_tag="BAY61_30015"
     CDS             complement(4686..5633)
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) delta9_cd03505"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028785.1"
                     /locus_tag="BAY61_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30015"
                     /product="acyl-CoA desaturase"
                     /protein_id="WP_091805547.1"
                     /sec_met_domain="delta9_cd03505 (E-value: 4e-105, bitscore:
                     351.7, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASPSPTESRPRRPKPMISGRTSLPEHVTVKAFVIVPLVAVAVA
                     VPFAWGWGLSWIDVGLGAFFFVISGLGVTVGYHRLFTHGSFKANRALRVALAIAGSFAA
                     QGQVTTWVADHRRHHAFSDRAGDPHSPWLFGTGPRALAKGFWHAHMGWLFDREVTNSQR
                     FAPDLLADKDIRMVDRLFPLWIAMSLLLPGIAGGLITWSVWGGVTAFFWAGLVRVGLLH
                     HVTWSVNSICHMIGERPFTSRDKAANFWPLAIFSFGEAWHNLHHADPTCARHGVLRGQI
                     DISARVIWLFEKLGWARDVRWPTSARLDRLATAK"
     gene            6131..6541
                     /locus_tag="BAY61_RS30205"
                     /old_locus_tag="BAY61_30020"
     CDS             6131..6541
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019814068.1"
                     /locus_tag="BAY61_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30020"
                     /product="thioesterase family protein"
                     /protein_id="WP_091805550.1"
                     /sec_met_domain="4HBT_2 (E-value: 4.2e-15, bitscore: 54.8,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYAHWELVPTRWKDNDVYGHVNNVVHYSLMDTVINDWLITEGGL
                     DIHTGDAIGLCVESHCNYLAAVEFPEKLAIGLRVGKLGRSSVRYEIGIHRANRSEVVAE
                     GHFVHVFVDRTSRRPVEITGRLRASLEALVVD"
     gene            complement(6552..8378)
                     /locus_tag="BAY61_RS30210"
                     /old_locus_tag="BAY61_30025"
     CDS             complement(6552..8378)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="BAY61_RS30210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30025"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_091805552.1"
                     /transl_table=11
                     /translation="MRLYLRTIGERWRALLVLLGCSVIEGVPAFATGWLVERAVSEGFQ
                     QGRVAFGIGVLGVLLALFGVGALGSLLVFSRLGSVVEPLRDVLAGAVVRGVLGVRALPR
                     CRIGEPDVPGILLRIEDVRQATGRLLGEIRGLVVTGVAAMAGLFVFAWQLALIVVVPVL
                     LSSVIVVLSMPRSLARQQDLALAQERAERSAADVFAGMRDVVSCGAEASAAAGVCADVD
                     RSERAAIAVARMAAVRAVAVGFGLLVPLLGVGFVAPGMVAEGRLTQGAAFGVLCYLVLG
                     VLPAFNGLATTSGTTGKLFTALRGLGGGGKPDPLPAGSVAPGHAGISLRGVTFRWGPDA
                     EPIVEGLSLDLVPGDRLTVVGESGLGKSTFAALLTGQLEPQRGRVLLGGEPVSRIAPAE
                     RHRIVGYLPSEPYLFAGSVRENLTVSSLSAGSVTDGQLLVSVAAVGAGEVVERLGGLSG
                     EVGHRNRGLSVADAQLLALARLYASPAKVVVLDEATSCLTAEAEARAERAFAARGGTLV
                     VMTSGPGPSPRQGRVLVLGTEPKHHADIRTQDAEIPARDAEMRIRAHDSDEPEVEHPIP
                     RQARGRGERETRPASAHADRVAGTDVPLGKQP"
     gene            complement(8375..8662)
                     /locus_tag="BAY61_RS30215"
     CDS             complement(8375..8662)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_091805555.1"
                     /transl_table=11
                     /translation="MRHLPLSEEETRRIGLARAIVRGPRVLIAERGTEDLAFRSLRGKT
                     RVVVTGSAATAESADVVVWLAHGRVRAVAKHEDLLAEPAYRAVFAEGGPR"
     gene            complement(8678..9970)
                     /locus_tag="BAY61_RS30220"
                     /old_locus_tag="BAY61_30030"
     CDS             complement(8678..9970)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BAY61_30030"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_091805558.1"
                     /transl_table=11
                     /translation="MSDRREAGLLLLTVLAAAATLVTPYALSAVADAVVAGELNWSRLG
                     ALLAVGGSQLGASAAATLLAAGITATMTARLRRGLTRQLCGFGTASPPGIGAARRGFTT
                     DCATAGSRPALFAALVSAVLVSSGSLVLLAILDWRLLGAFVISVLFAVPLAAKARHALD
                     AEDSGEHRPASELSALLRHAVAGLRTIAESGIAEHEARRVLRPLPLMHTAGVERWRAAA
                     RATWPARLALPLTCLAVLCAAGFGVTAGRLTIGELLAACCYAALGASFVPRIGLVGELR
                     RARSSAERVAEIRASPAPMAGTAKLPPGKGTIALRGVSVGTVLREVDLTVRSGSAVAVV
                     GRSAVGTEALAGVLAGLRPVETGEVLLDGVRMAELAPAQLRAAIGYAPTRPRLVGTSFA
                     DAIAYGSWAGSRAVDRACAAAGVGGLVARLP"
     gene            complement(10001..12556)
                     /gene="lanKC"
                     /locus_tag="BAY61_RS30225"
                     /old_locus_tag="BAY61_30035"
     CDS             complement(10001..12556)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030764.1"
                     /locus_tag="BAY61_RS30225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30035"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_342749598.1"
                     /sec_met_domain="micKC (E-value: 9.2e-258, bitscore: 856.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEGRRKIVDPRYEEFCVADRTFFAEPGEADDGLPEFSRVAPVPE
                     SGWCSWESGAWRTLLPDAVRLPSQGWKIHVSATLDNAESVLSRVHRYCLRRRVAFRHLR
                     NKTILLTRNAKYAPRESSGKLITIYPVGANAFAQILAELSSELEGERGPRVLSDLRYGD
                     GPLHARYGAFPRPGTSTDAVVSKPDGTVVADLVVPTFSVPEWVEVPHCLRPYLARRTRG
                     DEFPFRVTGSLHFSNGGGVYRAQRLTDDGDVVLKEARPYAGLDAEGTDAVSRLRREHAV
                     LNLLAGIDGVPGAHGLFSADEHLFLAMDEVAGEPLSAWHATNYPLTRAAATERDLADYA
                     TRAHRVVDAVRSVLADIHRRGIVYADLHPDNVLVAETGDQVAVSLVDFELAFPADEPGR
                     QALGAPGFRAPADKFGFEIDDHALASLALWLFLPVAPVLELAASRMGTLTELARRRFDL
                     PHAALPTPSCARSATATALDAAEPDWNDVTERVADAIVASATPARTDRLFPCDIAQFRL
                     GGSGFGYGAAGVLYALDAAGFGRYPEFEAWLLDALDRSPPRRAGFLDGAHGIAHVLAGF
                     GYRERAMDLVDAAEPLVESLEKNGNHGFGTGLAGIGLNLLFLGRVDEAERIGSGLAGRL
                     ATASTRVSTFAGAGLSRGWSGPALLFVSLFEYSADPVWLDLAEAAIERDLGECRTAFDG
                     SLRVSDGASRTLPFLGVGSAGIAIAIERLALHRPHARCLRLLPRLLLACHAEFSGSPGL
                     LGGAGGLVVALAAEQRRRADPELGETITRRLAGLACYAVPFGNGGIAFPGNGLLRLSMD
                     LSTGAAGVLLTISSTVDVRRPVFPFLGAQVGRADLVPVH"
     misc_feature    complement(12455..12457)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12895..13260
                     /locus_tag="BAY61_RS30230"
                     /old_locus_tag="BAY61_30040"
     CDS             12895..13260
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005460146.1"
                     /locus_tag="BAY61_RS30230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30040"
                     /product="hypothetical protein"
                     /protein_id="WP_091805565.1"
                     /transl_table=11
                     /translation="MITGYAVAVALCSLAVAAWAFVLVARNRPPKKPLLTGLAVIEVLL
                     LAQVVISVVLLIGGDRPGNMVTFIAYLVGSLLVLPIATVWALAERTRSATAILGVACVT
                     VPVLILRMSEVWGGASA"
     gene            13253..13705
                     /locus_tag="BAY61_RS30235"
                     /old_locus_tag="BAY61_30045"
     CDS             13253..13705
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156753.1"
                     /locus_tag="BAY61_RS30235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30045"
                     /product="hypothetical protein"
                     /protein_id="WP_091805568.1"
                     /transl_table=11
                     /translation="MPEEANQTADEQPATASGPGRVLIAIYAIFAVGATSRAAVQIATR
                     FDEAPFPYVLSAFAAVVYLLATFALARKGIGWWRVALAACSVELAGVLIVGTLSVFDTA
                     AFPDAAVWSNFGMGYLFIPLVLPVVGLLWLRKTHPSTAAGITRTPR"
     gene            complement(13686..14033)
                     /locus_tag="BAY61_RS30240"
                     /old_locus_tag="BAY61_30050"
     CDS             complement(13686..14033)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019807889.1"
                     /locus_tag="BAY61_RS30240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30050"
                     /product="hypothetical protein"
                     /protein_id="WP_091805571.1"
                     /transl_table=11
                     /translation="MDFVYDALVVLHLLGMAGIVAGLVVRASAPTGPGTKVMLYSAGAQ
                     VLTGVALVGLASSGVAGNEPDNTKVAVKLVIAMIILVLALIMHRKPRSGKGLFVTTAVL
                     TVANVAIAVFW"
     misc_feature    complement(14018..14032)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            complement(14065..14952)
                     /locus_tag="BAY61_RS30245"
                     /old_locus_tag="BAY61_30055"
     CDS             complement(14065..14952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787982.1"
                     /locus_tag="BAY61_RS30245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30055"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_091805574.1"
                     /transl_table=11
                     /translation="MILVGHQLAAAMAAAIVALWLLRSRWTHAHPRAALILWQISGLTL
                     VVSSVGALLGFGLAPFGRGLLPALVDLPLRIHELDLWHLTSVAAGLGLAGWLIANQLLS
                     LRSTARARARHRLLLQLVARPDTDALVVDHPAAVAYCLPGRTPRIVVSAGARQLLTAEE
                     LGAVLAHEQAHARERHHLVVAPFQALRRLLPRNKALIKVCSTIELLVEMCADDRAARQR
                     GREPLASALERFHANGAGGTPAGALAVSDTAVQARIRRLREPAAFGFPPAWPLACVVVL
                     TALGTSASLFAVPL"
     gene            complement(14949..15311)
                     /locus_tag="BAY61_RS30250"
                     /old_locus_tag="BAY61_30060"
     CDS             complement(14949..15311)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674142.1"
                     /locus_tag="BAY61_RS30250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30060"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_091805577.1"
                     /transl_table=11
                     /translation="MDVAKLGELERAVMDVLWARQEPVSVRAVHAALADRGLAYTTVMT
                     VLTRLAAKNVVRRERSGRAWLYAPAASREEYVAELMLEALELTGDRGSALVRFAQSVTN
                     DEAEALREALERGDEP"
     gene            complement(15338..16927)
                     /locus_tag="BAY61_RS30255"
                     /old_locus_tag="BAY61_30065"
     CDS             complement(15338..16927)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498560.1"
                     /locus_tag="BAY61_RS30255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30065"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_245865573.1"
                     /transl_table=11
                     /translation="MEVVRSNNGVTLRQLLVAIGKPLVELCTPEADPRVCGVAILDPDD
                     EPGSYQQDLVLVIGARGREAARFVRAAARRGAAVVAVKEAPAELAAVAREAGIALLGVA
                     PRMRWDQVETVVRQVLDAAALSEGSDEEPGDLFVLAQTLAALTGGSVSIEDAGNRVLAY
                     SRSDDEVDELRRLSILGWEGPRSYLALLREWGVFERLRSGEEVVRIDEHPELGIRRRLA
                     VGIRAGAQHLGTIWVQEGREAFADRADSALLGGARLAAVHLLRHRSEAGRPRNELVAGL
                     LDGKANPDLVAGQLGIDPAAACTVVGFAVREREPDQPVHELHRADMLSVVSVHMASYRK
                     GALVGASGSRVYAVLPDEPGLASLVADVARVLERRTGVRVQAGIGSPVPTLHEVPGSRA
                     EADRVLGAMGEANAVATISDLRAEVLLGETLSLLHGNPDLRDPAVASLVAHDEERGTEL
                     VPTLLAYLDAMGDVGAVAASLHVHPNTVRHRIRRAGQVSGIDFGDPRERLSCHLQLLLA
                     VTTVTTYNAIRG"
     gene            16987..18612
                     /gene="pruA"
                     /locus_tag="BAY61_RS30260"
                     /old_locus_tag="BAY61_30070"
     CDS             16987..18612
                     /EC_number="1.2.1.88"
                     /GO_function="GO:0003842 - 1-pyrroline-5-carboxylate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006562 - proline catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pruA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075672.1"
                     /locus_tag="BAY61_RS30260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30070"
                     /product="L-glutamate gamma-semialdehyde dehydrogenase"
                     /protein_id="WP_091805583.1"
                     /sec_met_domain="Aldedh (E-value: 2e-96, bitscore: 321.9,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAITSAPPPRNEPVRDYAPGSPERESIATTLSELARDRVELTAT
                     VDGEHYLPSGEPIDVVAPHDHARVLGTTANATTEDAKAAVAAALGAAAQWRALPFDERA
                     AVLLRAADLLSGPWRDTLNAATMLGQSKTVLQAEIDSACELADFWRFNVHFARELLAGQ
                     PESGDGSWNRMDYRPLEGFVYAVTPFNFTAIAGNLPTAPALMGNTVLWKPAQTQMLAAH
                     FTMRLLEEAGLPPGVINLLPGDGLAVSDVALADPALAGIHFTGSTATFQRLWSTVGGNI
                     ANYRTYPRIVGETGGKDFVLAHPSADPDVLRTALVRGAFEFQGQKCSAASRAFVPRSLW
                     NRIEADLASEVDSLTVGDVADFGNFMGAVIDRKSFDRLSGVLGMVRESPSLRVVAGGTA
                     NAESGYFVRPTVVVGTDPSHELFRTEYFGPVLGVHVYEDGDFDKVLGVVDGGSAYGLTG
                     SIIARDRAAITKASEALRFAAGNFYVNDKPTGAVVGRQPFGGARASGTNDKAGSVLNLL
                     RWTSPRTIKETFVPPVRVQYPHQG"
     gene            18621..19544
                     /locus_tag="BAY61_RS30265"
                     /old_locus_tag="BAY61_30075"
     CDS             18621..19544
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003068848.1"
                     /locus_tag="BAY61_RS30265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30075"
                     /product="proline dehydrogenase family protein"
                     /protein_id="WP_091805585.1"
                     /transl_table=11
                     /translation="MLRATIIAASRSPRCRSLVEGFPPVRPIVDRFVAGTTVSDALRVT
                     TRLADDRYVTLDHLGENTGSREQATETVLAYETAIRAIADEGLAARAEVSVKLSSLGLT
                     LPVDGPKVALDNTRRICAAAEAAGTTVTVDMEDHTSTDRTLSIVNQLRVDHPWTGTVLQ
                     AYLRRTEADCAALAGPRSRVRLCKGAYAEPADVAYQRKSDVDASYVRCLKLLIDGEGYP
                     MIATHDPRLIAIAETLVARSGRPHGSYEFQFLYGIRVSDQRRLAAEGHRVRVYVPYGSE
                     WYPYFVRRIGERPANLAFFARALAGG"
     gene            complement(19554..19805)
                     /locus_tag="BAY61_RS30270"
                     /old_locus_tag="BAY61_30080"
     CDS             complement(19554..19805)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019819773.1"
                     /locus_tag="BAY61_RS30270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30080"
                     /product="Prokaryotic metallothionein"
                     /protein_id="WP_091805587.1"
                     /transl_table=11
                     /translation="MATCEVCGNDYDMSFEVHTKGGGKHTFDSFECAIHRLAPVCEHCG
                     CRVIGHGIAVGGQFFCCAHCARVATEAGAQAKDAVPAS"
     gene            complement(19875..21893)
                     /locus_tag="BAY61_RS30275"
                     /old_locus_tag="BAY61_30085"
     CDS             complement(19875..21893)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005445806.1"
                     /locus_tag="BAY61_RS30275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30085"
                     /product="MMPL family transporter"
                     /protein_id="WP_091805590.1"
                     /transl_table=11
                     /translation="MRTVRWLIPALLMIGWLVIGGFGGPYSGKLSGVSENDESSFLPAS
                     AEATEVQELAKRFTGSEAIPAIVIAERQGGTNEADQRFLTERRGEIAGMAGVASEPSPV
                     LPSEDRAALQLVVPLDGAEPKETVEAMREALATGVPGGLSVYVTGPAGQVADLSEAFGG
                     IDGLLLLVAGAVVALILVVVYRSPLLPLAVLLSAVSALGLASLVVYLLADAGALALNGQ
                     SQGILFILVFGAATDYALLLVSRFREELRETEDKYVAIRKAWRGTIEPILASAGTVILG
                     LLCLLFSDLNSNKGLGPVAAIGIGAALLASTTFLPAMLAVLGRGAFWPFRPMAGSPHPE
                     SSGIWGRISRLVGRAPRAVWMVTALVLLVGAAFLPQLKADGTSQSDVFLTQVDSVTGGE
                     VLARHFPGGSGSPALVVANADTADAVAEAARVPGVSSVNEAGTAEGLVLIEAVLDAPAD
                     SEQAVSTVRDIREAVHEVPDAEALVGGRTAVLLDTQETSKRDRAVIIPIVLVVVFAVLA
                     LLLRSLLAPLLLVATVVLSFAATMGVSALVFNHLLGFPGADPVVPLFGFVFLVALGIDY
                     NIFLMTRVREEAKTLGTREGTLRGLSITGGVITSAGVVLAATFSALAVLPILFLAQLAF
                     IVAFGVLLDTLIVRSLLVPALTVDIGKRVWWPSRLSR"
     gene            21984..22457
                     /locus_tag="BAY61_RS30280"
                     /old_locus_tag="BAY61_30090"
     CDS             21984..22457
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156759.1"
                     /locus_tag="BAY61_RS30280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_30090"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_245865574.1"
                     /transl_table=11
                     /translation="MDETPSDELLVRRLRQVAVENERYIEALGEAHGMHRTDLNAVAVI
                     MDAAKDGRALSPTELANALHLSASATSSLLDRLETAGHITRDRSGRDRRRIELHVREEA
                     LAFGRQLHIPLAMEYQRAWEAFGASERRVIERFLNASIEATVRAKKQSFPRDQ"
ORIGIN
        1 gagcacacgg cgaggcaccg gtcagcgccg cttcgtgcac ctgggcaaga actcgcgcgt
       61 gccgccgggg gtcggtcccc accggcaccg ctgcctcaag gtgctccctg cgcacgctga
      121 ccagtgtcgc aagcctggtg ccggtaggga accctcctcg tcacctccgc ggagtgacga
      181 ggaggccgat cgcggcgacg acggcgccgg gttgctccat gtggaccatg tgtcccgcgt
      241 cctcgacgac cgtgacatcc ggccggtctc cgacgttggc gggcgggatg atcgcgtcct
      301 ggcttcccca cacgatgccg accggtacct ccacttcgga caatgtcgcc gtgatgtcga
      361 tgccctgccg ttcgccgtcg agcaggtttg ccagcagcga gttgagcgcc ttgtccacgc
      421 cgtcgatccg tttgtacttc atcaggtcgt ccgcgagttg cctcgtggcg agcgcggggt
      481 cggcgaacaa cgcgccgagg tgcggcttga gctcccttct cgacgtcgcc gcagcgaatc
      541 cacgcaggta gtcggcattg attccggttc cgatccccgc tggcgccacc agcgtcagcg
      601 aggcgacccg ctctggctcc gtcgcggcgg cggccgtgat caccgcaccg ccgagcgaat
      661 ggccgacgag atgcgctttc tcgatacccg ccgcttcgag gaagccgagt acggcccgcg
      721 cgagcacggc gagagagccg tccccgacat ccttgcccga ctcaccgtgt ccaggcaggt
      781 cgatggcatg caccgcgcgg tcccgcgaca gtggttcctg cacgaacagc cacgagttct
      841 tgtcgccccc gtagccgtgg acgagcacga ccggctcgct gccttcaccg agcgtcgcgt
      901 aggcgatgct ccctccatcg acgtcgaaag tcccggtcac cgggccggcg acctcctcga
      961 cggcgccgga gtccagttcc tcacgcgcgg ttcgcgcggc ctcgtcgatg tcggactccg
     1021 gtacctcggc gggggcgatg agcgcgatcg tccctcccac cggcacgtcc tcgccgaccc
     1081 ttgcgatgat cctgcgcagc accccttcgt cggcggattc gagcgcaccg gcgatcttgt
     1141 cggtgtcgat ttcggcgagg tcgtcaccgt cggcgacctc cgcaccttcc tcggcgaccc
     1201 actcggtgac tttcccgctc gtcatcgaca gcccccactt gggcatgacg accttccgga
     1261 tgacgtcgtc catgctcacc gcttccactc gacgacgctc ttgaccgcgt tggtcacccg
     1321 ctgcgcgtcg gggatgtaga gatcttcgag cgaatcggcg aacggcaccg gagtgtgcgg
     1381 cgccgtcacc agttcgatcg gcgccctcag cgagccgaac gcctccttgg ccacgagcgc
     1441 ggagacgtcg gtggccatgt tgcatcgcgg cgtcgcctcg tccaccacga cgagcctgcc
     1501 ggtgttctcg acactctcca gtatcgtctc ggtgtccagc ggactcgtcg tgcgaggatc
     1561 gatgatctcg gcctcgatcc ccgaatcggc aagggtcttc gccgcttctt ccgcgaccga
     1621 caccatcctg ccgatcgcga cgacggtcac gtcgcatccg tccctgacga cattggcctc
     1681 cccgaacgga atcgagtagc tgtcctccga aacctctccg gtgacgtcgt acatcgcctt
     1741 gtgctcacag aagatgacgg gatcatcgtc gcgaatggac tggatcatca gccccttcgc
     1801 ctcgtacgga ctcgaaggca cgaccacctt gagtccggga atgtgcgtga aaatcgaata
     1861 gagcgcctgc gaatgctggg ctgccgcccg caatcccgct ccgtacatcg tgcgaatgac
     1921 caccggtgtc ttcgccttgc caccgaacat gtagcggaac ttggccgcct gattgaagat
     1981 ctggtcgaaa cagactccca tgaagtcgat gaacatcagc tccgcgacgg gacgcatccc
     2041 actcgtcgcg gctccgacgg cggcaccgac gaaggccgac tcggagatcg gcgtgtcgag
     2101 cactctgcca ggaaaccggt ggaaaagtcc tttcgtgaca ccgagaacac cgccccacgc
     2161 gtcctcatcg ccggggccgc ctgctccacc agcgttgtcc tcacccatga cgatgaccga
     2221 ctcgtcgcgt tccatctcct gcgcgagagc ctcgccgatg gcctcgcgat agctgatcgt
     2281 gcgtgccatg tcgcctgcct ccctagtagg tgatgtacac gtcggtttcc agatcggccg
     2341 tgcccggttt gggagcggcc ttcgcctcgt ctacggcgac gtcgatcaac tcggcgaccg
     2401 aactgtccac ttcgtccaat gcgctttcct tgagtagccc ggtttcggtg acccgcttcc
     2461 tgaaccgctt gaggcagtcg aggttttccc tcgccttcgc gacctcgtcg gcacgatagg
     2521 tctgctggtc tccctcgaaa tgtccgaagt agcgggtgaa cttgacctcg acaagcgtcg
     2581 ggccgccgcc cgctctcgcc cgctcgatcg cctctccgac cgcctcgtgc accgcgaaga
     2641 agtcgaagcc gtcgacaatg acgcccggca tgccgaaccc ggcggccctg tccgcgatgt
     2701 tgtcggccgc gaccgaccag gtgctcgccg tcgcttcggc gtagccgttg ttctcggcca
     2761 cgaagatcgc gggcagattc cacaccgagg caaggttgag cgcttcgagt gtcgttccct
     2821 ggttgctcgc gccgtcgccg aagaacgcga cacccacgcc gcccgttccc tgtttcttcg
     2881 ccgcgagcgc cgttccgcag atcagcggag gaccgccgcc gacgatcccg ttggcaccca
     2941 gcattccttt cgaaaggtcg gcgatgtgca tcgagccgcc cttgccgtga cacgaaccgg
     3001 tcgttctgcc gtagatctcg gccatcatcg ccttgacgtc gacgcccttc gcgatgcaat
     3061 gtccgtggcc cctgtgcgta cttgcgatgg tgtcgcgctc gtcgaggtgc atgcacacgc
     3121 cggtggccga tgcctcctca cccgcgtaga ggtgcacgaa acccgcgatc tcgccggtcg
     3181 cgaactcggc gtgcagccgt tcctcgaagt tcctgatcgt gcgcatcgtc cggtaggcgt
     3241 cgagcagtgc gctttcgccg agttccccgt gagggctggt tgacttgtcg gacaaggtat
     3301 ccgtcatcgc ggtgacgctc cttcctcgct cacagtgcgc tgagttcttc gccgagccgc
     3361 cggtgcgact ggctttgctc cgtgcgaagc gatccggtgc gcgccgcttc ggcgagtacc
     3421 gcggccacgt cgacgcaccg aggcccctcc tcgctcaacc gcaccgtcgc ggccgtatcg
     3481 ccgctcagct ccagttcccg ttccccgtcg acggcgatca ccccgtgcgg gactccgatc
     3541 gcgactcgct cgccgaccgg caaccggcgc cacgaccgaa caccgacggg cacgacaagg
     3601 ccgggtgcga tcggggcgtg cacgacccac gccgcctctt ccggcggagc gaaggtcaac
     3661 gcgactcctg tcggctcgtc gcgcggactg gggcacaact ggcccgcgac gctggaaaga
     3721 ccgatcccat ccggttcggc gaacgtgcag aacagttcgg cgagcaaggt cggatcccac
     3781 agtgcccgcg aagcgacatg ccgggcggtc gaggtacaca cgtcgacgag cgcgggctcg
     3841 gtgcgatcac ccgccgtcac ttcgagcaac cccgcgcggc ggatgccggt ggtgatcgct
     3901 cccgtggcga cgagcccacc ggcaagcccg gccaccgtcg cctcgtgcat cttggggaaa
     3961 gcgttgttgg tgccggtcga gagcgcgagc agcggaacat ctccgcacgc gcctgccgcg
     4021 acgcgagcgg tgccgtcgcc tccgaggcac acgatcagtt cggcacccgc ggcgaccatc
     4081 ctggtcacgg cgttggtggt gtcgtcggca gtgccggtca agggatcctc gtcgcagaat
     4141 tcgacgagcg gccacgggcc ttcgcgctca gggcgcctcg tgcgcaatgc gcgaagtacg
     4201 gcggccgaga tgccgccgag atccgtggac agcaacgccc tgccgacgcc gaccgaggcg
     4261 aaagccgaga gcaggcggcg aaccatgttg gccttctcgg cggtggggaa caccgaagcc
     4321 tgggcgacga gacgccggat gtctcgcccg gaagccgggt tcgcgacgac tcccaccgtc
     4381 accggacgcg cgcccacaat cacctccacg gtgtgtcaca cgtcaccatc gacgtgtgac
     4441 tcccatggca ctaccgaagg gcgctgctgg gaaggagttg cagggggttg caaccggaat
     4501 ggagccgtct ttgaccggag tgggtgtcgg gtgtggccgg gcggccgggc ggctaggtga
     4561 ctcggtccgg gcagcttggt ccgggtgcgg aactcgccga cctggacggg gaactcgcgc
     4621 ggccgagtgc ggaactcgcc ggcctgagtg cagaagtcgg cggtctgagc gggggactcg
     4681 cgcggctact tcgccgtggc gagacggtcg agtcgcgccg aggtcggcca ccggacgtct
     4741 cgcgcccacc ccagcttctc gaacagccag atcacccttg ccgagatgtc gatctgccca
     4801 cgcaacacac cgtgccgcgc gcaggtcggg tcggcgtggt gcaggttgtg ccacgcctcg
     4861 ccgaacgaga agatcgccag cggccagaag ttggcggcct tgtccctgct ggtgaaggga
     4921 cgctcgccga tcatgtggca aatcgagttc acggaccagg tcacatggtg cagcaagccc
     4981 actcgcacca gacccgccca gaagaacgcc gtcacgccgc cccacaccga ccaggtgatc
     5041 aagccaccgg cgatgcccgg cagcagcagg ctcatggcga tccacagcgg gaagagcctg
     5101 tcgaccatcc tgatgtcctt gtcggcaagg aggtcggggg cgaaccgctg cgagttggtg
     5161 acctcgcgat cgaacagcca gcccatgtgc gcgtgccaga atcccttcgc aagcgccctc
     5221 ggtccggtac cgaacaacca cggcgagtgt ggatcgcccg ccctgtcgga gaaggcgtgg
     5281 tgccgccggt gatccgcgac ccatgtggtg acctgacctt gcgcggcaaa gcttcccgcg
     5341 atggcgagcg cgactcgaag cgcgcggttg gccttgaaag agccgtgcgt gaacagccgg
     5401 tggtacccga ccgtcacccc caagccgctg atcacgaaga agaaggcgcc gagcccgaca
     5461 tcgatccagc tcaaacccca gccccaggcg aagggaacag ccacagccac cgcgacgagc
     5521 ggcacgatca cgaacgcttt gaccgtgacg tgctccggaa gcgaggtccg cccggagatc
     5581 atgggtttcg gacgacgtgg tcgcgattct gtcggggacg gcgaagcaga catggacacc
     5641 tcagggtttc ggctgttctt ggcgttgtcg tcggggcttg gtgaggtacg tgcgtctcgc
     5701 gggttacggg cgcagcaatt ttggcgcccc gtcccgtacg cacggacgag cgccccgctt
     5761 ctgacacctg gatgagccgt actcgcggct aggtcgtgtc tgatgaacct ctgccgtgcg
     5821 agcggggatc agcgtggttc ctcgcaaggc ggagggaagt cctcgtaccg ggttgtactc
     5881 gggctttccg acaacgcggc gagggggcac gctggccccg cgcagtaggc tacgggtttg
     5941 tcggacacga cctagggccg acccccatcg gcctttggat caaattttgg tcgagctcct
     6001 atggaaggcg ccgccggggg gttgactccg ttctgctgag cggacttact gagcaatacc
     6061 taccttccgg acgctacccg atagcccggc ggtgcgccaa gaactcagag tggacagcta
     6121 gattcgaagc gtgacttacg ctcactggga gttggttccg accaggtgga aggacaacga
     6181 cgtatatggg cacgtcaaca acgttgtcca ctactcgttg atggacacgg tgatcaacga
     6241 ctggctgatc accgaaggcg gactcgacat tcacaccggc gacgcgatcg gtctgtgtgt
     6301 cgaatcgcac tgcaactacc tcgcggccgt cgagttcccc gagaagctcg cgatcggcct
     6361 gcgcgtggga aaactgggcc gatcgagtgt tcgctacgaa atcggaatac accgcgcgaa
     6421 ccggtcggaa gtggtcgccg aaggtcattt cgtgcacgtg ttcgtcgaca ggacgagtcg
     6481 ccgccccgtc gagatcaccg gccggcttcg cgcctcactc gaagcgctcg tcgtcgactg
     6541 agcgccggtg ctcaaggctg cttgccgagc gggacatcgg ttccagcgac ccggtccgca
     6601 tgggctgaag ccggtcgggt ctcgcgctcc ccgcgaccgc gcgcctgcct gggtatcggg
     6661 tgttcgacct ccggttcgtc actgtcgtgc gctcgaatgc gcatctcggc gtcccgggcg
     6721 gggatctcgg cgtcctgagt gcggatgtcg gcgtggtgct ttggctccgt tcccagcacc
     6781 aggaccctgc cctgcctcgg cgacggaccc ggcccggacg tcatcaccac cagggttccg
     6841 ccacgcgccg cgaacgccct ttcggctcgc gcctcggctt cggctgtcag gcaggaggtc
     6901 gcctcgtcga gcaccaccac cttcgccggg ctcgcgtaca acctcgccag cgcgagcaac
     6961 tgcgcgtcag cgaccgaaag gccgcgattc cggtggccga cctcgccgga caacccaccg
     7021 agccgttcga cgacctcacc cgcgccgacc gccgcgacgg agaccagcaa ctggccatcc
     7081 gtcaccgacc ccgccgacag cgaggacacg gtcagattct cccgcaccga acccgcgaag
     7141 aggtacggct cactcggcag gtagccgacg atccggtgcc gctcggcagg cgcgatcctg
     7201 ctgaccggtt cgccgccgag cagcaccctt ccccgctgcg gttcgagctg tccggtgagc
     7261 agcgccgcga acgtcgactt gccgagcccg ctctcgccga cgaccgtcag gcgatcgccg
     7321 ggaacgaggt cgaggctcag cccttcgacg atcggctcgg catccggtcc ccagcgaaac
     7381 gtcaccccgc gcagactgat gcccgcgtgc ccgggagcga cggatccggc aggcagcggg
     7441 tcgggcttgc ctccaccgcc gagtcctcgc agcgcggtga acagcttccc cgtggttcca
     7501 ctcgtcgtag cgagtccgtt gaaggcaggc aacactccca gcacgagata gcacagcaca
     7561 ccaaaagcgg cgccttgcgt gagccgacct tccgcgacca tgcccggtgc cacgaatccg
     7621 accccgagca acgggacgag caggccgaaa ccgacggcga cagcccgcac ggccgccatg
     7681 cgcgcgacgg cgatggccgc tcgttcggat cggtcgacat cggcgcacac acctgccgcc
     7741 gccgaagctt ccgccccgca cgacacgacg tcgcgcatgc ctgcgaacac gtcggcggcg
     7801 gatcgttccg cccgctcctg agccagcgca aggtcctgct gcctggccag cgatctcggc
     7861 atcgacagca cgacgatcac cgacgacaac agcaccggca cgacgacgat caacgccagt
     7921 tgccacgcga acacgaaaag ccctgccatc gccgcgaccc cggtgacgac gagccctctg
     7981 atctcgccga gcaggcgccc ggtcgcctgc ctgacgtctt cgatccgcag cagaatcccc
     8041 ggcacgtccg gttcgccgat gcggcacctc ggcagcgccc gcacgccgag gacaccgcga
     8101 acgaccgcgc ccgcgagcac gtcacgtagc ggctccacga ccgaacccag cctgctgaac
     8161 accagcagcg agccaagcgc gccaaccccg aagagcgcga gaagtacccc gagcacgccg
     8221 attccgaacg cgacccttcc ctgctggaag ccttcgctca ccgcacgctc gacaagccat
     8281 ccggtcgcga aagcgggaac gccttcgatc acggagcagc cgagcagcac gagcagtgct
     8341 cgccaccgct cgccgatcgt cctcaggtac agcctcatcg tggtccgcct tcggcgaaga
     8401 cggcacgata ggcgggttcg gcgagcaggt cctcgtgttt cgcgacggct cgcacccttc
     8461 cgtgcgcgag ccagacgacg acgtcggcgg actcggccgt cgcggcgctg cccgtcacca
     8521 cgaccctggt ctttccccgc agtgaacgga aggcgagatc ttcggttccc cgctcggcga
     8581 tcagcacgcg cggaccacgc acgatcgccc tcgccagccc gatacgtcgg gtctcctctt
     8641 cggacaacgg caggtgccgc aaggaagtgt ggtgacctta gggcagcctc gcgacaagac
     8701 cgccgacccc tgccgcggcg cacgcgcggt cgacggcccg cgaaccggcc cagcttccgt
     8761 acgcgatcgc gtcggcgaag ctcgtaccca ccagccgagg ccgggtgggc gcgtagccga
     8821 tggcggcgcg caactgtgcc ggcgccagtt cggccatccg gaccccgtcg agcagcacct
     8881 cgcccgtttc gacgggacga agccccgcga gcacgcccgc gagcgcctcc gtgccgaccg
     8941 ccgagcggcc gacgacggcg acagcactgc ctgaccgcac cgtcaggtcg acctctcgca
     9001 gcaccgtacc gacgctgacg ccgcgcaacg cgatcgttcc cttgccaggc ggcagtttcg
     9061 cggtcccggc catcggcgcg gggctcgcac ggatctcggc gacgcgctcg gcactcgacc
     9121 tggctctcct gagttcgccg acgagcccga ttcgcggcac gaagctcgcc ccgagcgccg
     9181 cgtaacagca cgcggcgagc agttcgccga tggtcagtct gcccgccgtg acaccgaatc
     9241 cagccgcgca cagcacggcg aggcaggtga gcggcaacgc gagtcgggct ggccaggtcg
     9301 cgcgggccgc cgcgcgccac ctttcgacac cggcggtgtg catcagcggc aacgggcgga
     9361 gcactcggcg ggcctcgtgt tcggcgatgc cgctttccgc gatcgtcctg agtccggcga
     9421 cggcgtggcg cagcagcgcg gagagttcgc tcgccggacg gtgctcaccc gagtcttcgg
     9481 catcgagagc atggcgcgcc ttcgcggcga ggggaaccgc gaacaacacg ctgatcacga
     9541 aggcgccgag cagcctccag tcgaggatcg cgagcagcac cagcgaacca gaggacacga
     9601 gcacggctga gacaagcgcg gcgaagagag cgggccgcga gcccgctgtc gcgcagtccg
     9661 tggtgaaccc gcgccgcgcc gcgccgatcc ctggcggcga tgcggtcccg aacccgcaca
     9721 gctgccttgt cagccccctg cgcaaccggg cggtcatcgt cgcggtgatc ccggcagcga
     9781 gcagcgtcgc ggctgcggac gcgccgagct ggctgcctcc gaccgcgagc agcgcaccga
     9841 gccgcgacca gttcagctca ccggcgacga cggcgtcggc gacagcggac agcgcgtagg
     9901 gcgtcaccag cgtcgccgcg gcggcaagca ccgtgagcag cagcagtccc gcttcgcgcc
     9961 ggtcgctcac cccgccctcc tagcctgctc gtcgtcggaa tcagtggacc ggcacgaggt
    10021 ccgctcttcc cacctgggcg cccaggaaag gaaacaccgg ccgacggacg tccacagtgg
    10081 aggatatggt gagcagtacg cccgcggcgc ctgtcgacag gtccatcgat agccggagca
    10141 atccgttgcc gggaaaggcg attccgccgt tcccgaacgg cacggcgtag cacgcgagac
    10201 cggccaggcg acgcgtgatc gtctcgccga gttccggatc ggcccttctg cgctgttcgg
    10261 cggcgagcgc gacgacgaga ccacccgcgc caccgagaag cccgggactt cccgagaact
    10321 cggcatggca ggcgagcaac aggcggggca gcagccggag gcaccgcgcg tgggggcggt
    10381 ggagcgcgag ccgctcgatc gcgatcgcga tacccgcgct accgacgccg agaaacggca
    10441 aggttcggct ggcgccatcg gaaacccgaa gcgatccgtc gaaggcggta cggcattctc
    10501 cgagatcacg ctctatcgcg gcctcagcga ggtcgagcca gactgggtcg gccgagtact
    10561 cgaacagcga gacgaacaac agcgcgggcc ccgaccagcc ccggctgagt cccgcgcccg
    10621 cgaacgtgct caccctggtg ctcgccgtgg cgaggcgacc agcgagtccg ctcccgatgc
    10681 gctccgcttc gtccaccctg ccgaggaaaa gcaggttgag cccgatcccg gcgagaccgg
    10741 tcccgaaacc gtgattcccg ttcttttcaa gggattccac gagcggttct gcggcgtcga
    10801 cgaggtccat ggcccgctcg cggtagccga acccggcgag tacgtgcgcg attccgtgcg
    10861 ccccgtcgag gaagcccgct cgccgaggag ggctccggtc gagcgcgtcg agcaaccacg
    10921 cctcgaactc ggggtacctg ccgaaacctg ccgcgtcgag cgcgtagagc accccggcgg
    10981 ctccgtaccc gaagccgcta ccaccgagcc ggaattgcgc gatgtcgcag gggaagagcc
    11041 ggtcggtacg cgcgggagtc gcgctggcga cgatggcatc ggcgacgcgc tccgtgacgt
    11101 cgttccagtc aggttcggcc gcgtcgagcg cggtggccgt cgcgctccgc gcgcacgagg
    11161 gcgtcggcaa cgcggcatgc ggaaggtcga agcgccgcct cgccagttcg gtcagtgtgc
    11221 ccatccggga ggccgcgagt tcgagaacag gagcgacggg gaggaacagc cacagcgcga
    11281 gcgaggcgag cgcgtggtcg tcgatctcga aaccgaactt gtcggcggga gcgcggaagc
    11341 caggcgcgcc gagcgcttgc cgccccggtt cgtcggcggg gaaggcgagt tcgaaatcga
    11401 cgagggacac cgcgacctgg tcgccggtct cggcgaccag gacgttgtcg ggatgcaggt
    11461 cggcgtagac gatgccgcga cggtggatgt cggcgagcac tgagcggacc gcgtcgacga
    11521 cgcgatgcgc tctcgtcgcg tagtcggcca ggtcccgctc ggtcgccgct gccctcgtca
    11581 acggatagtt ggtggcgtgc catgcggaaa gcggctcgcc cgcgacctcg tccatcgcga
    11641 gaaataggtg ctcgtccgcg gaaaagagac cgtgcgcgcc ggggacgccg tcgattccgg
    11701 cgagcaggtt caggacggcg tgttccctgc gcagtctcga tacggcgtcg gtcccttccg
    11761 catcgagccc ggcgtatggc cgcgcttcct tgagtacgac gtccccgtcg tcggtcagcc
    11821 gctgcgcgcg gtagacgccg cctccgttgg agaagtgcag cgaaccggtg acgcggaagg
    11881 gaaactcgtc tcctcgggtt cgcctggcga gatacgggcg aaggcagtgg ggcacctcga
    11941 cccactccgg cacggagaag gtggggacga cgaggtcggc gacaacggtg ccatcgggtt
    12001 tgctgacgac cgcgtccgtg ctcgttcccg gcctggggaa agcgccgtag cgcgcgtgaa
    12061 gcgggccgtc gccgtagcgg agatcgctca gcacccgagg cccccgctct ccttcgagtt
    12121 cggaggagag ctcggcgaga atctgtgcga aggcgttggc tcccaccgga tatatggtga
    12181 tcagctttcc gctcgactct ctcggcgcgt atttcgcgtt cctggtgagc agaatcgttt
    12241 tgttccgcag gtgtctgaag gcgactcgtc gccgtaggca gtatcggtga acgcgggaca
    12301 gcacgctctc cgcgttgtcg agtgttgccg aaacgtggat tttccagcct tgacttggaa
    12361 gccggaccgc gtcggggagc agcgtgcgcc acgctccgga ctcccacgag caccaccccg
    12421 attccggaac tggggcaacc cgcgagaact cgggtaagcc atcatcggcc tcacctggtt
    12481 cggcgaagaa agtccggtcc gcgacgcaga attcctcgta acgagggtcc acgattttcc
    12541 tccgtccctc gttcacatca tcgaccggcc accggtaatt tccccacgaa ggactcgggc
    12601 cgccaatccg ccagttcagc ggttcggctg ggctgaaagg gaggctgggt ttgtcgttac
    12661 ccatcggtat ttgcgctgtg cgtgagcgga ggttttcacc ggcctcaccc ggttgagaac
    12721 ccggcgacga aaagccaggt gggcagctca gccctgcccc gtgccaacta cccgaaaagg
    12781 cgacggcgga cggctatcgc aaagcgcgcc atcacggtag tggcgagcgc cctgcccaag
    12841 gccacgtcga ccggccccgt atgctacggg tagtagtagc gttgtggagg accagtgatc
    12901 accggatatg ccgtcgccgt ggcgctgtgc tcgctggccg tcgcggcgtg ggccttcgta
    12961 ctcgtcgcca gaaaccgccc gccgaagaaa ccgttgctga ccggactcgc ggtcatcgag
    13021 gtactactgc tcgcgcaggt ggtgatctcg gtcgtgctgc tcatcggagg cgatcggccc
    13081 ggcaacatgg tcaccttcat cgcctacctc gtcggttcgc tgcttgtgct gccgatcgcg
    13141 acggtgtggg ctctggccga acgcacgcgt tcggccacgg cgattctcgg cgtggcctgc
    13201 gtgaccgtgc cggtgctcat tctcaggatg tcggaggtct ggggtggcgc gagtgcctga
    13261 ggaagcgaac cagaccgccg acgaacagcc cgcgacggcg agcggccctg gcagggtact
    13321 catcgcgatc tacgcgatct tcgccgtcgg cgcgacctcc cgcgcggcag tgcagatcgc
    13381 gaccaggttc gacgaggcac cgtttcccta cgtgctttcg gctttcgccg cggtcgtgta
    13441 cctgctggcc acgttcgcgc ttgcccgaaa gggaatcggc tggtggcgag tcgcgctcgc
    13501 cgcgtgctcc gtcgaactgg caggcgtact catcgtcgga acgctgagcg tgttcgacac
    13561 cgcggcgttc cctgacgccg cggtgtggtc caacttcggg atgggctacc tgttcattcc
    13621 gttggtgttg cctgtcgtcg gcctgctgtg gctgcgcaag acgcacccga gcacggccgc
    13681 cgggatcacc agaacaccgc gatagccacg ttggcgacgg tcagcaccgc cgtcgtcacg
    13741 aagagcccct tgccgctccg cggcttcctg tgcatgatca gcgccagcac gaggatgatc
    13801 atcgcgatca cgagcttgac ggcgaccttg gtgttgtcgg gctcgttgcc ggcgaccccc
    13861 gaggaggcga gcccgacgag cgcgacaccg gtgagcacct gtgcaccggc gctgtagagc
    13921 atgaccttgg ttccggggcc ggtcggcgcg ctggcacgca ccacgagacc ggcgacgatg
    13981 ccagccatac caagcaggtg cagaacgacg agagcgtcgt aaacgaaatc catgacgaga
    14041 atttactaca aggtgtagta aatctcagag cgggaccgcg aaaagcgaag ccgacgttcc
    14101 cagcgccgtc agcactacca cgcaggcaag cggccacgcc ggtggaaagc cgaacgcggc
    14161 cggttcgcgc agcctgcgaa tccgggcctg tacggcggtg tcggagaccg cgagcgcacc
    14221 ggcaggcgtg ccaccggcac cgttcgcgtg gaaccgttcg agcgcgctcg ccaacggctc
    14281 ccttccccgc tgcctcgccg ccctgtcgtc cgcgcacatc tcgacgagca attcgatcgt
    14341 cgaacacacc ttgatcagtg ccttgtttct cggcagcagc ctgcgcagag cctggaacgg
    14401 agcgacgacg aggtggtgcc gctcgcgagc gtgtgcctgc tcgtgcgcga gtacggcgcc
    14461 caactcctcg gcggtcagca gctgccttgc ccccgcgctg accacgatgc gcggcgtgcg
    14521 gccgggaagg cagtaggcga cagcggcggg atgatcgacg acgagagcgt cggtgtccgg
    14581 ccgcgcgacg agctggagca gcagccggtg ccgcgctcgc gccctcgcgg tactacgcag
    14641 gctcagcagc tggttggcga tcagccaacc cgcgagcccg agtccggcgg cgacggaggt
    14701 gaggtgccac agatccagct cgtggatccg cagcgggaga tcgacaaggg cgggaagcag
    14761 tcccctgccg aatggggcaa gaccgaatcc gagtagcgcc ccgacgctcg acaccaccag
    14821 ggtcagcccg ctgatctgcc agagaatcag ggcggctcgc ggatgcgcgt gggtccagcg
    14881 gctgcgcagc agccagagcg ccacgatcgc ggccgccatg gccgcggcga gctggtgccc
    14941 caccagaatc acggttcatc gcctcgttcc aacgcctcgc gcagcgcctc ggcctcgtca
    15001 ttggtgaccg actgcgcgaa acgaacaagc gccgagcccc tgtcacccgt gagttcgagg
    15061 gcctccagca tcaactccgc gacgtactcc tcacggctcg ccgccggtgc gtagagccac
    15121 gcccttcccg agcgttccct ccgcacgacg ttcttggcag ccaacctggt cagcacggtc
    15181 atcacggtcg tgtaggcaag accgcgatcg gcgagcgcgg catgcactgc gcgcacgctg
    15241 accggttcct ggcgtgccca cagcacgtcc atcaccgcgc gctccagttc tccgagcttc
    15301 gccacgtcca tcccttcgcc gccgttgcag gagaaattca accacgaatc gcgttgtagg
    15361 tggtcaccgt tgtgacggcg agcaacaact ggaggtggca ggaaagccgt tccctcggat
    15421 cgccgaagtc gatgccgctg acctgccccg ccctgcggat ccggtgtcgc accgtgttgg
    15481 ggtggacgtg cagcgaggcc gcgaccgcgc cgacgtcgcc catcgcgtcg aggtaggcga
    15541 gcagggtcgg caccagctcg gtccctcgct cctcgtcgtg agcgaccagc gaggcgacgg
    15601 cggggtcacg caggtcgggg ttgccgtgca gcaacgagag tgtttccccg agcagcacct
    15661 cggctctgag atcggagatc gtcgcgacgg cgttggcttc ccccatcgcg ccgagcaccc
    15721 tgtcggcctc cgcgcgcgac cccggcacct cgtgcagcgt cggaacgggg gagccgatcc
    15781 cggcctgcac cctgaccccg gttcgccgct ccagcactcg cgcgacatcg gcgaccagcg
    15841 aggcgaggcc aggttcgtcc ggcaacacgg cgtacacgcg agaaccggaa gcgccgacca
    15901 gcgcgccctt gcggtaggag gccatgtgca ccgagacgac gctgagcatg tcggctctgt
    15961 gcagctcgtg gaccggctga tcgggctcgc gctcgcggac ggcgaacccg acgaccgtgc
    16021 acgcggctgc cgggtcgatg ccgagctgac ccgcgacgag atcgggattg gctttgccgt
    16081 ccagcagccc cgcgaccagt tcgtttctcg gcctgcccgc ttcgctgcgg tgccgcaaca
    16141 ggtgaacggc ggcaaggcgt gctccgccga gcagcgcgct gtcggctcgg tccgcgaacg
    16201 cttcccttcc ctcctgcacc cagatcgtgc cgaggtgctg cgcgcctgcc ctgatgccga
    16261 ccgcgagccg cctcctgatg ccgagttcgg gatgctcgtc gatgcgcacg acctcttcgc
    16321 cggagcgcag ccgctcgaag actccccact ccctcagcag cgcgaggtag ctcctcggcc
    16381 cctcccagcc gaggatcgac agccgccgca gctcgtcgac ctcgtcgtcg gagcgggagt
    16441 aggcgagcac tctgttgccg gcgtcctcga tgctgacgct gccgccggtc agggccgcaa
    16501 gcgtttgcgc cagcacgaag aggtcccctg gctcctcgtc gctgccctcg gaaagcgcgg
    16561 cggcgtcgag cacctgcctg acgactgtct ccacctgatc ccagcgcatg cgcggagcga
    16621 cgccgagcag cgcgatcccc gcttcgcggg cgacggccgc cagctcggcc ggagcctcct
    16681 tgaccgcgac gaccgctgcc cctcgcctcg ccgccgccct gacgaacctg gccgcctccc
    16741 tgccgcgcgc gccgatgacc agcacgaggt cctgctggta actgccaggc tcgtcgtcgg
    16801 ggtcgaggat ggcgacgcca cacacgcggg ggtccgcctc cggggtgcac agctcgacca
    16861 gcggctttcc gatggcgaca agcaactgac gcaaggtcac gccattgttc gatcgaacaa
    16921 cctccacgac tcaacggtag ccgaatcacc aatccgtagg gaccgtccga gccctagctt
    16981 gctgacatgg acgcgattac cagtgcaccg ccaccccgta atgaacccgt ccgcgactac
    17041 gcccctggtt cgcccgagcg cgagagcatc gcgaccacac tctccgaact ggcgcgcgac
    17101 cgcgtcgaac tgaccgcgac cgtcgacggc gagcactacc tcccctccgg cgagcccatc
    17161 gacgtcgtcg caccccacga ccacgcgcgc gtcctcggca cgacggccaa cgcgaccacc
    17221 gaagacgcca aagccgccgt cgcggccgcg ctaggggcgg cggcgcaatg gcgcgcattg
    17281 cccttcgacg agcgagccgc cgtactgctc agggcagccg acctgctgag cgggccgtgg
    17341 cgggacaccc tcaacgcggc gaccatgctc ggccagagca agaccgtctt gcaggcggaa
    17401 atcgactctg cctgcgaact cgccgacttc tggcggttca acgtgcactt cgcgcgcgag
    17461 ctgctggcgg gacagccgga gagcggcgac gggagctgga accggatgga ctaccggccc
    17521 cttgaagggt tcgtgtacgc cgtaacccct ttcaacttca ccgcgatcgc gggcaacctg
    17581 ccgaccgcgc cggcgctgat gggcaacacg gtgctgtgga agcccgcgca gacccagatg
    17641 ctggccgcgc acttcaccat gcggctgctt gaggaagcgg gtctcccgcc cggcgtcatc
    17701 aacctgcttc ccggcgacgg gctcgcggtc tccgatgtcg cgctcgccga tccggcgctg
    17761 gccggtatcc acttcaccgg ctcgacggcc accttccagc gtctgtggtc gacggtgggc
    17821 ggcaacatcg ccaactaccg gacctatccg aggatcgtcg gtgagacagg gggaaaggac
    17881 ttcgtgctcg cgcatccgag cgcggacccc gacgtgctgc gcaccgcgct ggtgagggga
    17941 gctttcgagt tccagggcca gaagtgctct gccgcgtccc gcgcgttcgt tccccgctcg
    18001 ctgtggaacc gcatcgaagc cgaccttgcg tccgaagtgg actccctgac tgtcggggac
    18061 gtcgccgact tcggcaactt catgggggcc gtgatcgaca ggaagtcctt cgaccggctc
    18121 tccggggtgc tcggcatggt gcgtgaatcg ccatcgctgc gggtggtggc aggaggaacg
    18181 gcgaacgcgg agagcggcta cttcgtgcgg ccgaccgtcg tggtgggaac cgacccctcc
    18241 cacgaactgt tccgcaccga gtacttcgga ccggtactgg gcgttcacgt atacgaggac
    18301 ggcgacttcg acaaggtact cggcgtcgtc gacggcggct cggcttacgg gctgaccggt
    18361 tcgatcatcg cgagggacag ggccgcgatc acgaaggcga gcgaggcatt gcgattcgcg
    18421 gcaggcaact tctacgtcaa cgacaagccg acgggagccg tcgtcggaag gcagcccttc
    18481 ggcggggccc gcgcgtcggg aaccaacgac aaggctggtt cggtgctcaa cctgctcagg
    18541 tggaccagcc cgcgcacaat caaggagacc tttgtccctc cggttcgggt ccagtaccca
    18601 caccagggtt aggaacaatc atgttgcgag caaccatcat cgccgcttcg cgttcgccgc
    18661 gttgccgctc actcgtcgag ggatttcctc cggtcaggcc gatcgtggac cggttcgtcg
    18721 cggggacgac ggtatccgac gcgctgcggg tgacgacgcg actcgccgac gacaggtacg
    18781 tcaccctcga tcacctcggc gagaacaccg gcagcaggga acaggcgacg gagacggtgc
    18841 tcgcctacga gacggcgata cgcgcgatcg cggacgaagg gctcgccgcc agggccgagg
    18901 tctcggtcaa actgtcctct ttgggcctga ctctgccggt ggacgggccg aaggtcgcgc
    18961 tcgacaacac ccgcaggatc tgcgcggctg ccgaggccgc ggggacaacg gtcacggtcg
    19021 acatggagga tcacacgagc accgaccgga ccttgtcgat cgtgaaccag ctcagggtcg
    19081 accacccgtg gaccggcacc gtgttgcagg catacctgcg gcggacggaa gccgattgtg
    19141 ccgcgctggc agggccgcgt tccagggtgc ggttgtgcaa aggcgcctac gccgagccgg
    19201 ccgacgtcgc gtatcagcga aagtccgatg tggacgcttc ctatgtgcgc tgcctcaagc
    19261 tgctcatcga cggcgagggc taccccatga tcgcgacaca cgacccgagg ctgatcgcga
    19321 tcgcggaaac ccttgtcgca cgatccggga ggccgcacgg cagctacgag ttccagttcc
    19381 tttacgggat cagggtttcc gatcagcgca ggctcgccgc cgaagggcac agggtgcggg
    19441 tgtacgtgcc ctacggcagc gagtggtatc cgtacttcgt ccggcgcatc ggcgagcggc
    19501 ccgcgaacct cgcgttcttc gcgagggcac tcgcgggcgg ctaggtgtat tggctaggaa
    19561 gcgggtacgg cgtccttggc ttgcgcgccc gcctccgtcg ccactcgcgc acagtgcgcg
    19621 cagcagaaga actggcctcc gacggcgata ccgtgtccga tcaccctgca cccacagtgc
    19681 tcacacacgg gggcaaggcg gtggatggcg cattcgaagg agtcgaacgt gtgcttgcct
    19741 ccacctttgg tgtgcacctc gaaagacatg tcgtagtcgt tcccgcacac ctcgcaggtt
    19801 gccattgcgt cgtcacctcc agatccgcac ggctatgcga acgtaggcat tcccgcatgc
    19861 ggcatacgca aacgtcaccg ggaaagccgt gaaggccacc agacccgttt gcctatgtcc
    19921 acggtcagcg cgggcaccag cagcgatcgc acgatgagcg tgtcgagcag aaccccgaac
    19981 gccacgatga aagccaactg ggcgaggaac aagatcggca gaacggccag ggcggagaag
    20041 gtggccgcga gcacgacgcc agccgaggtg atgacgccac cggtgatact caggccccgc
    20101 agtgtgcctt ccctcgtccc gagcgtcttc gcctcctctc tgaccctggt catcaggaag
    20161 atgttgtagt cgatcccgag cgcgacgagg aagacgaacc cgaacagcgg tacgaccgga
    20221 tcggctcctg ggaaaccgag caggtgattg aagaccagcg ccgagacacc catggtcgcc
    20281 gcgaacgaca gcacgaccgt ggcgacgagc aacaacggag cgagcagcga acgcagcagc
    20341 agggcaagca ccgcgaacac cacgacgagc acgatcggga tgatcaccgc ccggtcgcgt
    20401 ttggacgttt cctgggtgtc gagcaggaca gcggttcttc caccgaccag cgcctccgcg
    20461 tcgggaacct cgtgcaccgc ctcgcgaatg tcgcgcaccg tcgacacggc ttgctcggaa
    20521 tccgcaggcg cgtcgagaac ggcctcgatg agcacgagcc cttccgccgt tcccgcttcg
    20581 ttcaccgagg aaaccccagg tacccgtgct gcttccgcga cggcgtcagc cgtgtcggcg
    20641 ttggcgacga cgagcgccgg cgatcctgag ccacccggga agtgccttgc cagcacctca
    20701 ccaccggtga cggagtcgac ctgggtgagg aacacatccg actgggaggt gccgtcggct
    20761 ttgagctgtg gcaggaacgc cgcacccacc agcaacacga gcgcggtgac catccagaca
    20821 gccctcggag cgcggccgac gagccgggag atccgtcccc agatgccgct cgactcggga
    20881 tgcggcgagc ctgccatcgg ccggaacggc cagaaggcgc ccctgccgag caccgcgagc
    20941 atcgcgggaa ggaaggtggt cgaggcgagt agcgccgcgc cgatgccgat cgcggcgacc
    21001 ggaccgagcc ccttgttcga gttgaggtcg ctgaacagca ggcagagcaa cccgagaatg
    21061 acggtgccag cggaagcgag gatgggttcg atcgtgcctc gccatgcttt ccggatggcg
    21121 acgtacttgt cctcggtctc cctcagttcc tccctgaacc gggacaccag cagcagcgcg
    21181 tagtccgtcg ccgcgccgaa gacgaggatg aacaggatgc cctggctctg tccgttcagc
    21241 gcgagcgcgc ccgcgtcggc gagcaggtag acgacgagac tcgcgaggcc gagcgccgac
    21301 acggcggaga gcagcacggc gagcggcagc agcgggctgc ggtagacgac cacgaggatc
    21361 aacgcgacga cggcacccgc gacgaggagc agcagtccgt cgatcccgcc gaacgcctcg
    21421 ctgagatcgg cgacctgacc cgccgggccc gtgacgtaca cggagagtcc gcctggcacg
    21481 ccggtggcga gcgcttcgcg catcgcctcg acggtttcct tcggttcggc gccgtcgagc
    21541 ggaacgacga gctgcaacgc ggccctgtcc tcagagggca gcaccggcga cggctcgctc
    21601 gcgacaccgg ccatgcccgc gatctcaccc ctgcgctcgg tcaggaaccg ctggtcggcc
    21661 tcgttggtgc caccttgccg ttcggcgatg actatggcgg ggatcgcctc gctaccggtg
    21721 aagcgtttgg ccagctcctg gacttcggtg gcttcggccg acgctgggag gaaggaggac
    21781 tcgtcgttct ccgagacgcc gctcagcttg ccggagtagg gaccgccgaa gccgccgatg
    21841 accagccagc cgatcatgag cagtgcggga atcagccaac gaaccgtgcg cacgggcctc
    21901 gccttacttc gatcgtcgaa acattcggtg atcgaaatac taagctaggt cttccgacgg
    21961 cgcccgacgg gtagggggaa caggtggacg agacaccgag cgacgaacta ctcgttcgaa
    22021 ggttgcggca ggtcgccgtc gaaaacgaga gatacatcga ggcgcttggt gaagcacacg
    22081 ggatgcaccg caccgacctc aacgccgtcg ccgtgatcat ggacgccgcc aaggacgggc
    22141 gggcgctgag tcccaccgaa ctggcgaacg cgcttcacct gagtgcctcg gcgacgagct
    22201 cgctgctcga tcgcctcgaa acggcaggcc acatcacgag ggaccgcagc ggaagggacc
    22261 gcaggcgaat cgagctgcac gtgcgcgagg aagcactggc cttcggaagg cagctccaca
    22321 ttccgctcgc catggagtac cagcgggcgt gggaagcgtt cggcgcctcc gaacggcgcg
    22381 tcatcgaacg ctttctcaac gcgagcatcg aggcgacggt gcgcgcgaaa aagcagagct
    22441 ttccccgcga tcagtaaggc agcaccgcgg cactcttctc aagaacggac tgaacccggg
    22501 ttgacccggg gtgcttcact gggtcacaag catgaaaacc ggaacccccc tcaccg
//
