LOCUS       NZ_CP016353            22223 bp    DNA     circular CON 03-MAY-2024
DEFINITION  Prauserella marina strain DSM 45268 chromosome, complete genome.
ACCESSION   NZ_CP016353
VERSION     NZ_CP016353.1
KEYWORDS    RefSeq.
SOURCE      Prauserella marina
  ORGANISM  Prauserella marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Prauserella.
REFERENCE   1  (bases 1 to 6851918)
  AUTHORS   Ruckert,C., Albersmeier,A., Jiang,C.-L., Jiang,Y., Kalinowski,J.,
            Winkler,A. and Zotchev,S.B.
  TITLE     Complete genome sequence of Prauserella marina DSM 45268, isolated
            from ocean sediment of the South China Sea
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6851918)
  AUTHORS   Ruckert,C., Albersmeier,A., Jiang,C.-L., Jiang,Y., Kalinowski,J.,
            Winkler,A. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 33.7x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002240355.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:59:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,595
            CDSs (total)                      :: 6,536
            Genes (coding)                    :: 6,497
            CDSs (with protein)               :: 6,497
            Genes (RNA)                       :: 59
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 14 of 39
            Pseudo Genes (incomplete)         :: 31 of 39
            Pseudo Genes (internal stop)      :: 1 of 39
            Pseudo Genes (multiple problems)  :: 6 of 39
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:50:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4589990
            Orig. end                         :: 4612213
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP016353.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22223
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22223
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22223
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12223](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12223)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(55..2910)
                     /gene="uvrA"
                     /locus_tag="BAY61_RS21520"
                     /old_locus_tag="BAY61_21410"
     CDS             complement(55..2910)
                     /EC_number="3.1.25.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014467399.1"
                     /locus_tag="BAY61_RS21520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21410"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_091809842.1"
                     /transl_table=11
                     /translation="MADRLVVRGAREHNLRGVDIDLPRDSMIVFTGLSGSGKSSLAFDT
                     IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITE
                     VYDYLRLLYARAGKPHCPQCGEPISKQTPQQIVDQVLDMQEGTRFQVLAPVVRGRKGEY
                     VDLFANLQQQGYARARVDGTVYSLTDPPKLKKQEKHEIGVVVDRLTVKASSKQRLTDSV
                     ETALRLADGLVELEFVDLPEHDPHRTRGFSENLACPNGHPLAIEDLEPRSFSFNSPYGA
                     CPECTGIGVRKEVDPELVVPDDELSLAEGAIAPWSGGQSADYFERLLESLAQTIGFRMD
                     VPWRRLPAKAQKAVLHGVDDQVHVKYRNRYGRQRSYYASFEGVIPFLERRHEQTESEWS
                     RERYEGYMREVPCPACQGTRLKPEILAVTLEHAQQGERSIAEVCAFSVSEASVFLDELV
                     LGKRESMIAGAVLKEIQARLHFLLDVGLDYLSLDRAAGTLSGGEAQRIRLATQIGSGLV
                     GVLYVLDEPSIGLHQRDNHRLIDTLTRLRDLGNTLIVVEHDEDTIKSSDWVVDIGPGAG
                     EHGGHIVHSGPYKKLLKNRKSLTGEYLSGRRVIDVPAIRRPVDKKRQLTVVGAREHNLR
                     GIEVSFPLGCLVSVTGVSGSGKSTLVNDILATVLANKLNNARQVPGRHTRIKGLDQVDK
                     LVRVDQSPIGRTPRSNPATYTGVWDHVRKLFAATTEAKVRGYQQGRFSFNVKGGRCEAC
                     AGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTVSDVLDMPIEEAAEFFEP
                     IKAIHRHLQTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGKTVYVLDEPTT
                     GLHFEDIRKLLAVINGLVDKGNTVIVIEHNLDVIKTSDWIVDMGPEGGSGGGTVVAQGS
                     PEDVAVVEGSYTGQYLKPVLT"
     gene            complement(2966..4162)
                     /locus_tag="BAY61_RS21525"
                     /old_locus_tag="BAY61_21415"
     CDS             complement(2966..4162)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005448921.1"
                     /locus_tag="BAY61_RS21525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21415"
                     /product="acyltransferase"
                     /protein_id="WP_338061499.1"
                     /transl_table=11
                     /translation="MTATPAPATATSSRKMSWDVIRVVAIFFVIAGHVTGLASRIPGIE
                     GYPFSLAIPFGTVTLLVLSGYFIGPTIRKGDAGRWLRARLSRLLPAYLVAVLLTYCVTR
                     YAVVTFNGWWHQPGVLGMLFGDPVRPSVPTVEFPWHVPDLNDLLLNVLLLHEWNPDLVH
                     RIDGSYWTLPVQVIAFVCAALLWRSKLRHRVRPHTVLWAVTAISAASPLLSLFMSSVPT
                     ATGTFYGHLFAAGMAIWLWQHDRLPSLQLVMLLSAAVGLHALRASAPEVASVIGLAVML
                     VLMCLAAKGPDWDVPVVRLLRRPISWLAGISFGLYLVHQQLGYVLARWLSEAGFGPWWL
                     RLTVIVTAVVVAAWLLTVLVERPAYRVLTRPRTRGTNSAVAVPTRANAEPAVSVGGAT"
     misc_feature    complement(3143..3145)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4330..5004
                     /locus_tag="BAY61_RS21530"
                     /old_locus_tag="BAY61_21420"
     CDS             4330..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159192.1"
                     /locus_tag="BAY61_RS21530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21420"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_091809839.1"
                     /transl_table=11
                     /translation="MNVVDEYTGHVEPGGDATRRTLDALTISKLSVGPMDNNAYLLVCR
                     ATNEALLIDAASDSERISDLIGHGPDRPALRTVVTTHQHPDHWQALGAVAGANGSYTAA
                     HPADADPLPVPPDHLVEHGDTLSVGDCTLEVIHLRGHTPGSIALLYRDKERPHLFTGDS
                     LFPGGVGKTNSAEDFTSLLDDVEQRVFAQLPDETWFYPGHGDDSTLGEQRPHLAEWRER
                     GW"
     gene            complement(5038..6414)
                     /locus_tag="BAY61_RS21535"
                     /old_locus_tag="BAY61_21425"
     CDS             complement(5038..6414)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025638.4"
                     /locus_tag="BAY61_RS21535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21425"
                     /product="DUF4365 domain-containing protein"
                     /protein_id="WP_211323633.1"
                     /transl_table=11
                     /translation="MPDARRAGRAAVNALRTLLERHNHIVQEVDGQNDFGEDLHVTFTE
                     NGEVAGDLVKIQVKGGRSWRRADGYAVPVGDHGDTWANGNIPVLCVVHDPDTGGLYWVN
                     ATKELRSARRDGEVLKTITISPNEQLADNSIVDFVAEVRHYLSLYRGNRVIQAQLGETA
                     GVEFGPSDIVQHHVNVYGEDLIFWQRRGEGFATLLHSDLDWYPQHFGPEHFHPGGRPGL
                     LPRAPGVAQTILNTAEAHWLEACIDAAQWAREPAAGEPPLHTNIDARDNYVARRIEHRL
                     WIEPDALTRAIQKVRTDTTADHELITTLRELESDAEADAEALSTPWREMSEKARRLVTF
                     YLVKEVRVGSPSLPIDEQFRIVWRCPRPTAEYGFGARIGQPSTRRLVNRELVLAFQLRP
                     GDRIFWLSRYGNERGRTVSAVWDSEDTPGAVCVLFDQLMLGDTFWPEERFVRKVSAKTR
                     "
     gene            complement(6494..6898)
                     /locus_tag="BAY61_RS21540"
                     /old_locus_tag="BAY61_21430"
     CDS             complement(6494..6898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103980.1"
                     /locus_tag="BAY61_RS21540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21430"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_170140298.1"
                     /transl_table=11
                     /translation="MAERHEAGVLDTCTYIDLGLLDSSALPKIPELTAVTMAELHQGVA
                     MAKDAEVRAARTEKLGAAIVDFAPLPFDGDAAARYGTLVALVLAANRDPRPRRMDLMIA
                     AIASSRALPLYTRNEADFTGLGNMVEVVGI"
     gene            complement(6891..7169)
                     /locus_tag="BAY61_RS21545"
                     /old_locus_tag="BAY61_21435"
     CDS             complement(6891..7169)
                     /GO_process="GO:0008219 - cell death [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028075.1"
                     /locus_tag="BAY61_RS21545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21435"
                     /product="type II toxin-antitoxin system prevent-host-death
                     family antitoxin"
                     /protein_id="WP_091809834.1"
                     /transl_table=11
                     /translation="MKVITQREFRNNSAAVMDAVEAGEIYHVTRNGVEVAELRPVPRRR
                     RLTAEELVQRHRGLPKVEAAQMRQEADEFFGTEDRVDPDDAWERDRG"
     misc_feature    7354..7368
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            complement(7570..7914)
                     /locus_tag="BAY61_RS33635"
                     /old_locus_tag="BAY61_21440"
     CDS             complement(7570..7914)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BAY61_21440"
                     /product="hypothetical protein"
                     /protein_id="WP_245865313.1"
                     /transl_table=11
                     /translation="MLGDTGSAAITHRGEQGQDKPLQKGGFLRENSSEQFVGECRVVRP
                     CRSGDCFQWVFTRGLRGAGRRASFTVLSDLVAHRPGTEVLILDELGEQLHVDSLRVVGE
                     NVAARWVSRT"
     gene            7901..8104
                     /locus_tag="BAY61_RS33640"
     CDS             7901..8104
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS33640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245865315.1"
                     /transl_table=11
                     /translation="MSPSTGADLATEASTAWFGRTCSASTGSTSRPSGTRLAELMVLHN
                     VGVQDESVFVLKKVDEDFFDQP"
     gene            8287..9426
                     /locus_tag="BAY61_RS21555"
                     /old_locus_tag="BAY61_21445"
     CDS             8287..9426
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663717.1"
                     /locus_tag="BAY61_RS21555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21445"
                     /product="esterase-like activity of phytase family protein"
                     /protein_id="WP_245865316.1"
                     /transl_table=11
                     /translation="MTSSFAPAFVAALMTATTALTPATAEAAEQPVRLLGEAIIPHKMD
                     YEGTTVGGLSGIDRDPCTGEYVMISDDRSYQQPARFYTAAIDVDAAGVHGVDISGTHAL
                     RQPDGATYPSPTAKDGKAVDPEEIRVDPWNCQYWWSQEGNRPKDLASDEPLIQPSIQAS
                     TRHGGYLRSLPLPADYTITRDEQGPRRNLVLEAITFDRGGATLTSAVEGPLVQDGEEPT
                     TEQGALTRVTTQSRSGEVLAQYAYPLDPLFAEADPTSPWSPDTGVPAILADPDEPGRYL
                     VLERTYVPGAGFGVKIFTADVRGATDTRGTRSLATVGIQPMHKEPLVDLADLPLSTVDN
                     VEGMTWGPDLPSGERTLVLVSDDNFAEEEVSQVIALAVG"
     misc_feature    complement(8300..8315)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.42"
                     /tool="antismash"
     gene            9445..9957
                     /gene="rnhA"
                     /locus_tag="BAY61_RS21560"
                     /old_locus_tag="BAY61_21450"
     CDS             9445..9957
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rnhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420383.1"
                     /locus_tag="BAY61_RS21560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21450"
                     /product="ribonuclease HI"
                     /protein_id="WP_091809831.1"
                     /transl_table=11
                     /translation="MADSGANVVEIYTDGACSPNPGPGGWGAVLRYGDHERELHGGEPA
                     TTTNNRMELTAPIEALEALTRPSVVALYTDSSYVRNGITQWLARWKSNGWLTSAREPVK
                     NADLWQRLEAAAAPHTIEWHWVKGHAGHPDNERADRLAASGMREALGAQGDAPSASSPS
                     TPVTATG"
     gene            complement(10001..12223)
                     /locus_tag="BAY61_RS21565"
                     /old_locus_tag="BAY61_21455"
     CDS             complement(10001..12223)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667245.1"
                     /locus_tag="BAY61_RS21565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21455"
                     /product="Geosmin synthase"
                     /protein_id="WP_091809829.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-81, bitscore: 273.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAFTLPDFYLPYPARINPYLERSREHTMAWAERMGMLDAAAHQG
                     GVVWTEDELAAMDYALMCAYTHPDCGGVELDLITDWYVWVFFFDDHFLDQFKYSRDTAG
                     ARHYLDRLELFMTEDGETPPEPENPAEAGLKDLWERTIPSMSAGWRRRFITSTHNLMVE
                     SMWELENIERGRIANPIEYIQMRRRVGGAPWSANLVEYAVGAEIPDNLAATRPMRVLTD
                     TFADAVHLRNDLFSYQREVREEGENSNAVLVFESFLDCPTQDAAELVNDLLTSRLHQFE
                     HTALTEVPALFAEYAVPPDGQAGVTAYVKGMQDWQAGGHEWHARSSRYMNEGAEKPGVG
                     GLSGLGTSAGRLSLLPGSRQRVRRHSHIPFQPVGHLELPEIRMPYPARVNPHLDQSRAD
                     MITWAREMGFYDSLPGVEAGGVWDEDRCAGIDLPHCASGLHPGADLDALNLASHWLAWG
                     TYGDDYYPVVFGAGRHLPEAKAQTERLKMFMPLDLESPAEPVNGLERGLADLWLRTAGP
                     MPDPARARFRDTVDDMLDAWLWELINQAQNRIPDPIDYVEMRRKTFGSDMTKALSRLTE
                     SAIVPEELFHNRVLHELDTAAQDFAMFVNDLFSYQKEIQFEGELHNMVLVVENFLDVER
                     ARARDIVVRLVDARLEQFEHIADVDLPAMCAELDLAQPVREALEGHVEHFKNWMSGILE
                     WHRKCVRYQEQELRRVAGGISRRDRSFLPSGPGTELARLGTLLGAG"
     misc_feature    complement(10016..10018)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12396..12409)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(12462..12884)
                     /locus_tag="BAY61_RS21570"
                     /old_locus_tag="BAY61_21460"
     CDS             complement(12462..12884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005459433.1"
                     /locus_tag="BAY61_RS21570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21460"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_091809827.1"
                     /transl_table=11
                     /translation="MSFVMTAEERESFLADVHVGILAVERNGRAPLAVPVWYDVDDGDV
                     VVWMDRDTVKDKAITAAGRFSLVVQSETPPYRYVTAEGPVVSNGEPPSREQALAIAGRY
                     LPEADAESYVGTDLGDRSILVRMRPRYWLSNDQSKT"
     gene            complement(12962..13918)
                     /locus_tag="BAY61_RS21575"
                     /old_locus_tag="BAY61_21465"
     CDS             complement(12962..13918)
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (20-108). E-value:
                     4.6e-08. Score: 25.5. Matches aSDomain:
                     nrpspksdomains_BAY61_RS21575_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020495314.1"
                     /locus_tag="BAY61_RS21575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21465"
                     /product="SRPBCC family protein"
                     /protein_id="WP_091809825.1"
                     /transl_table=11
                     /translation="MNQRLGTVTLVEGKPLLRFERTFPHPREKVWRAITDPAELAHWFP
                     AEPDFEPAARAPIRFGFPAADDAFAHGEVVEFDRPKVFAFSWADSLLRFELLPMKGGCT
                     LVFTHLLNGTDTSGDLPSVARQAPGWDGCLDRLGCLLSGENRESAAGAWFLERAEEYVE
                     RFGLARGSIEHEGNGWLITFERDLVSSISDVWTLLAGDGEIRPGTEPPVAFTHGYQPTG
                     AITEAVPGRVLEYAVPEDSSDSGRVRFELRDQLPIGTRLVLSQHVPFASEADRATLLAA
                     WQTHLELLFAALAGDVRCPWPSERTEALRESYARAVS"
     aSDomain        complement(13595..13858)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BAY61_RS21575_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.60E-08"
                     /label="BAY61_RS21575_Polyketide_cyc2.1"
                     /locus_tag="BAY61_RS21575"
                     /protein_end="108"
                     /protein_start="20"
                     /score="25.5"
                     /tool="antismash"
                     /translation="RTFPHPREKVWRAITDPAELAHWFPAEPDFEPAARAPIRFGFPAA
                     DDAFAHGEVVEFDRPKVFAFSWADSLLRFELLPMKGGCTLVFT"
     misc_feature    13870..13881
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.0"
                     /tool="antismash"
     gene            complement(13932..14363)
                     /locus_tag="BAY61_RS21580"
                     /old_locus_tag="BAY61_21470"
     CDS             complement(13932..14363)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (16-114). E-value:
                     1.5e-11. Score: 36.8. Matches aSDomain:
                     nrpspksdomains_BAY61_RS21580_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019928.4"
                     /locus_tag="BAY61_RS21580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21470"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_091809823.1"
                     /transl_table=11
                     /translation="MNNALHKAGEHWELRFERNFAHPPSTVWRAITEPEQLSQWYPFAA
                     VEWNFTVGGTLLFRDDEGTEVRAEVTEIDPPKAFAFEEFDEETGVHLLRFELTGTAEGC
                     VLRFTHSFADSTWAAQTETGWLACLDVLDRVVSGAAAEG"
     aSDomain        complement(14022..14315)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BAY61_RS21580_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.50E-11"
                     /label="BAY61_RS21580_Polyketide_cyc2.1"
                     /locus_tag="BAY61_RS21580"
                     /protein_end="114"
                     /protein_start="16"
                     /score="36.8"
                     /tool="antismash"
                     /translation="ERNFAHPPSTVWRAITEPEQLSQWYPFAAVEWNFTVGGTLLFRDD
                     EGTEVRAEVTEIDPPKAFAFEEFDEETGVHLLRFELTGTAEGCVLRFTHSFAD"
     gene            complement(14360..14713)
                     /locus_tag="BAY61_RS21585"
                     /old_locus_tag="BAY61_21475"
     CDS             complement(14360..14713)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010692932.1"
                     /locus_tag="BAY61_RS21585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21475"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_091809821.1"
                     /transl_table=11
                     /translation="MATTFEVLAEPRRREILDLLRDGERVVGDLVERLPIPQSSVSKHL
                     RILREAGLVAVRHDAQRRWYRISPGPLREIDDWLAPYRRLWDDALDKLERHLDTMSDGP
                     AETVHNARKERES"
     gene            complement(14755..16173)
                     /locus_tag="BAY61_RS21590"
                     /old_locus_tag="BAY61_21480"
     CDS             complement(14755..16173)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS21590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BAY61_21480"
                     /product="hypothetical protein"
                     /protein_id="WP_091809819.1"
                     /transl_table=11
                     /translation="MTTTAPRPEAAATEAEQRQLKEFFEGTRTLPQLLATLRSRRVAMG
                     YRMESGTEETSRGGRRLFQPRGPLAFVSEHPVVPLSEVEEAIVAWAACGPNGMAHWDIA
                     SSGGFHELVRIAGRTAAGPGNSFAHDLLVVKDEGAFIYDPGTERERMVEIEGEKDYHKV
                     LDWYRTGLRKVHDGRPDIDWALRAPGAPNASLFGPYQYNINREGTTWFVPVTDVGWLYF
                     SALLNIFDAWHVYLVDDRTGLPAGTSKWVGEGKLEFPITISQFEQFIFQVETYPPGSMV
                     QNMRLAAEALGLGNWIFCGFFDDVLMGAFPDVTPGLGFVHEPLNERAPAASGALKTFGV
                     PGVKEATYVPSPAYPDGTAVVAAMLEQKYGDGATMSRGEDNWMLRHHGPYTEQTVRALV
                     ESPAVRISDWAAEACAACFDYCVEHYGQAPVYFNPMQCNFGAVVHHVDPAFYEKYYDGS
                     SVTPQIKSHFREWH"
     gene            complement(16210..17874)
                     /locus_tag="BAY61_RS21595"
                     /old_locus_tag="BAY61_21485"
     CDS             complement(16210..17874)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024583.4"
                     /locus_tag="BAY61_RS21595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21485"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_091809817.1"
                     /transl_table=11
                     /translation="MALEGLLRRLLSASAVSAAAQAAVDTVRDVLPAEISWSGVVSGDD
                     IRLAAYGGLRTAEMPALWHLAVGQGIGGRVAKERRTIAVRDYRRDPRRVPVMKSIIDAE
                     GVRGGACAPLLCGDDVLGVLYAADRRPRDWTDSELRLLTDIGRDTGVALAQIRERHLHR
                     ERCETAERAAHAGTRAVEVLGAIAMSLVRTEDLSAGIGVLAHHIGMSVALLDPDGRPLY
                     KAPPGDDDSEPVRVEVGVGEEPFGILRVSGTREPERSERELVEVSGYLVTLQLLRERAA
                     LRAESRVHSEFLDSLLLGRFTDREDMLARAALLDVALTEPRFVVCISAKNGKDPGGADA
                     AQASTLPTLTRRMFIHVEEKVRRHYPRSMVNPRAGEVVVLLQPDGDDLGLVLKTLREGV
                     IPEEGKGLDLVAGVGRLCLALEDYPDSYAEAVLALDIARRGSKAGEVLAQGDLGLYGLL
                     ARAPSRQSLESIVDSALGPLLEADTAGGTDYVRTLHAYLDADRHLERAAADLHVHPNTV
                     RYRLAKAQHMLGVSLRDVNERFLLELALRVQRALERQ"
     misc_feature    17938..17952
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     gene            18063..19658
                     /locus_tag="BAY61_RS21600"
                     /old_locus_tag="BAY61_21490"
     CDS             18063..19658
                     /NRPS_PKS="Domain: AMP-binding (12-409). E-value: 7.3e-72.
                     Score: 234.1. Matches aSDomain:
                     nrpspksdomains_BAY61_RS21600_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="BAY61_RS21600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21490"
                     /product="AMP-binding protein"
                     /protein_id="WP_091809814.1"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-71, bitscore:
                     238.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRPRRVVEELVRARAEAHPDTVWLKWLDEEISWLTALSLSKRAA
                     NGLLELGVRPGERVALLLPNRPEFIWTHLAIQIIGAHSVPVNISQRGATLAHILTDSGA
                     SVIVFHDKLRDAVLSVRHRLPSVRRLVVCDGPAGGGIDWNTERLFACADTEPETGAATS
                     ETGAGSGVGMMYTSGTTGPPKGVVTADYDLRPVEALVRAAGVRPGETMYTGLPLFHGNA
                     LLVSMLGSIFADAKLALAPKFSASRLLSDCARYGAVEFNTLGGMISILLKQPPSPLDRE
                     HEVRVVLSAGCPANRWREFEDRFGIRIVEWFGMVDSPGILLNDTGRVGSMGRGGVAGIE
                     FRVVDDADRPLGPQEVGELVFRHPRGATTSYHNLPGATARAYRGGWFHSGDLADYDEDG
                     FFYYRGRKRESMRRLGENVSAWEIESVLNTHPAVLDSAAHAVASELGDEDIKVCVVLRS
                     AYDAEPGELLLFCVERMAYHAVPRYVEFLEALPKTATERNQYATLRERGLTPSTWDRET
                     EGSSWLKSRSPARP"
     aSDomain        18099..19289
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BAY61_RS21600_AMP-binding.1"
                     /evalue="7.30E-72"
                     /label="BAY61_RS21600_AMP-binding.1"
                     /locus_tag="BAY61_RS21600"
                     /protein_end="409"
                     /protein_start="12"
                     /score="234.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RARAEAHPDTVWLKWLDEEISWLTALSLSKRAANGLLELGVRPGE
                     RVALLLPNRPEFIWTHLAIQIIGAHSVPVNISQRGATLAHILTDSGASVIVFHDKLRDA
                     VLSVRHRLPSVRRLVVCDGPAGGGIDWNTERLFACADTEPETGAATSETGAGSGVGMMY
                     TSGTTGPPKGVVTADYDLRPVEALVRAAGVRPGETMYTGLPLFHGNALLVSMLGSIFAD
                     AKLALAPKFSASRLLSDCARYGAVEFNTLGGMISILLKQPPSPLDREHEVRVVLSAGCP
                     ANRWREFEDRFGIRIVEWFGMVDSPGILLNDTGRVGSMGRGGVAGIEFRVVDDADRPLG
                     PQEVGELVFRHPRGATTSYHNLPGATARAYRGGWFHSGDLADYDEDGFFYYRGRKRE"
     CDS_motif       18579..18623
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BAY61_RS21600_0001"
                     /evalue="9.80E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="BAY61_RS21600"
                     /protein_end="187"
                     /protein_start="172"
                     /score="18.3"
                     /tool="antismash"
                     /translation="MMYTSGTTGPPKGVV"
     gene            19625..20833
                     /locus_tag="BAY61_RS21605"
                     /old_locus_tag="BAY61_21495"
     CDS             19625..20833
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013673505.1"
                     /locus_tag="BAY61_RS21605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21495"
                     /product="thiolase family protein"
                     /protein_id="WP_091809812.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.4e-06, bitscore:
                     26.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEVQIAGAAMTRFGKFATSTIRSLSEEAVAAALADAGIAARDVD
                     AVFFGNAAAGLLTGQEMIRGQVALRNTGLLGVPIANVENACATAATAFHLAVTAVHSEV
                     VDIALAVGAEKLTHVDKRRSFAALSAAVDLFAFSELSRTVPVTQESAAPIRRPKLHSVF
                     MDVYAATTRAYLARSDAKPRDFAEVAVKNHRHAALNPKAQSRERVTVEQVLGSPVVAAP
                     LTMLMCSPIGDGAAAIVVCSARRAKALGAARVRVRACALVSGTTSAVPGSRVRAAAHAY
                     EQAGVGPSDIDVLELHDAAAPAELIGYEHLGLCGQGEGAALLRSGATRLGGAHVVNPSG
                     GLLAKGHPIGATGCGQLVELADQLRGRCGPRQVPGARVALAENGGGLIGEDAAATVVTV
                     LST"
     gene            20845..21627
                     /locus_tag="BAY61_RS21610"
                     /old_locus_tag="BAY61_21500"
     CDS             20845..21627
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="BAY61_RS21610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BAY61_21500"
                     /product="nitroreductase family protein"
                     /protein_id="WP_091809810.1"
                     /sec_met_domain="PF00881 (E-value: 1.8e-12, bitscore: 46.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFKRVIGTRRTIRFFEPNRAVEPEKIQIMLEAANRASRAVNADF
                     VKAIVCYRDELTDEVREQLKTPTTTVQLDLAPVAIFWYGDLAFADNAQSRLKELVDLGA
                     LPVTHGWSHSYVDDVAVAQSVEPMSKDAMASTWAVSVESGLAIAQAMLAGVDEGLGVGL
                     HSFEAETAKAVLKVPDNWIPMWMLLVGYPAESHEAGGQRPRRPLGDNFHRGQYGSPWDE
                     IPEVTERLKKEGMIQAPMDPTLRFAEIRRLAERFGLPL"
     gene            21624..21989
                     /locus_tag="BAY61_RS21615"
                     /old_locus_tag="BAY61_21505"
     CDS             21624..21989
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BAY61_RS21615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BAY61_21505"
                     /product="hypothetical protein"
                     /protein_id="WP_091809808.1"
                     /transl_table=11
                     /translation="MNTLSTGAFSGDRSVRHWLSELEPYREGRAATSARLAVLGAFCAH
                     AGKSPDELVAFCFLRKKTTGQRFLSGARRRAVNGMLEKFVAEQGWIGKEAVSNTNVVRS
                     FLIHNGILIQGAVWRGP"
ORIGIN
        1 gccgcccagc ggacctggcc accccggcag gcgccgcgac gggcgtggcg acgctcaggt
       61 gaggacgggc ttcaggtact ggcccgtgta gcttccctcg acgaccgcga catcctcggg
      121 acttccttgc gcgaccacgg ttccaccgcc ggagccgccc tcgggcccca tgtcgacgat
      181 ccagtccgac gtcttgatca cgtcgaggtt gtgctcgatg acgatcacgg tgttgccctt
      241 gtcgaccaac ccgttgatga cggcgagcag cttgcggatg tcctcgaagt gcagccccgt
      301 cgtcggctcg tccagtacgt acaccgtctt gcccgtcgac cgcttttgca gctcgctggc
      361 gagcttgact cgctgcgcct ccccgcccga cagggtggga gcgggctgac cgagccgcac
      421 gtaaccaagc ccgacgtcca ccagggtttg caggtgccgg tgaatggcct tgatcggctc
      481 gaagaactcg gctgcctcct cgatgggcat gtcgagcaca tcggacaccg tcttgccctt
      541 gtagtgcacc tcaagggttt cccggttgta ccgcgcgccc ttgcacacct cgcacgggac
      601 gtacacgtcg ggaaggaagt tcatctcgat cttgatggtc ccgtcacccg cgcacgcctc
      661 gcacctgccg cccttgacgt tgaacgagaa ccgcccctgc tggtagccac gcaccttggc
      721 ctcggtggtc gccgcgaaca acttgcgcac gtggtcccac acaccggtgt aggtcgccgg
      781 gttcgacctc ggcgtacggc cgatgggcga ctggtcgacc cgcacgagct tgtcgacctg
      841 atcgagaccc ttgattctgg tgtgcctgcc tggcacctgc ctcgcgttgt tgagcttgtt
      901 cgccagcacc gtcgcgagaa tgtcgttgac gagagtggac ttgcccgagc cggagacacc
      961 ggtgaccgaa acgaggcacc cgagcgggaa cgagacctcg ataccccgca ggttgtgttc
     1021 acgcgcaccg acgacggtga gctgccgctt cttgtccacc ggcctgcgaa tcgcgggaac
     1081 gtcgatgacc cttcgccccg aaaggtactc gcccgtcagc gatttccggt tcttgagcag
     1141 cttcttgtaa ggtccactgt ggacaatgtg gccgccgtgc tcgcccgcgc caggaccgat
     1201 gtcgaccacc cagtcgcttg acttgatggt gtcctcgtcg tgctcgacca cgatcagcgt
     1261 gttgccgaga tcgcgcagcc gggtgagcgt gtcgatcagc cggtggttgt cgcgctggtg
     1321 cagcccgatc gacggctcgt ccagcacgta cagcaccccg acgagtcctg agccgatctg
     1381 agtggccagc cggatccgct gggcctcgcc tcccgacagc gtgccggcgg ccctgtcgag
     1441 cgagaggtag tcgaggccca cgtcgagcag gaagtgcagc cgggcctgga tttccttgag
     1501 caccgcgccg gcgatcatgg actcgcgctt gccgagcacc agttcgtcga ggaagaccga
     1561 agcctccgac accgaaaacg cgcacacctc ggcgatcgac cgttcgccct gctgagcgtg
     1621 ttcgagcgtc accgcgagta tctccggctt cagccgggtg ccctgacagg cagggcaggg
     1681 cacctcgcgc atgtagccct cgtagcgctc acgcgaccat tccgactcgg tctgctcgtg
     1741 gcgccgttcg aggaacggga tgaccccctc gaagctcgcg tagtacgagc gctgccttcc
     1801 ataccggttg cggtacttga cgtgcacctg gtcgtcgaca ccgtgcaaaa cggccttctg
     1861 cgccttggcg ggcagccttc gccacgggac gtccatgcgg aatccgatgg tctgggcgag
     1921 cgattcgagc aaccgttcga agtagtccgc gctctgccct cccgaccacg gcgcgatggc
     1981 gccctcggcc agcgacagct cgtcgtctgg cacgaccagt tcgggatcga cctctttgcg
     2041 cacaccgatg cccgtgcatt cgggacaggc accgtagggc gagttgaacg agaacgaccg
     2101 gggttcgagg tcctcgatgg cgagcggatg cccgttgggg caggcaaggt tctccgagaa
     2161 gccacgcgtg cggtgcggat cgtgctcggg gaggtcgacg aattccagtt cgaccaggcc
     2221 gtccgcgagt cgcagcgccg tctcgaccga gtcggtcagc cgctgcttcg agctcgcctt
     2281 gaccgtcagc cggtcgacca cgaccccgat ctcgtgcttc tcctgcttct tcagcttcgg
     2341 cggatcggtg agcgagtaca ccgtgccgtc caccctcgcc cgcgcgtagc cctgctgctg
     2401 caagttcgcg aacaggtcga cgtactcgcc cttccttccc ctcaccacgg gcgccagcac
     2461 ctggaaccgg gtgccttcct gcatgtcgag cacctggtcg acgatctgct gaggagtctg
     2521 cttgctgatc ggttcaccac actgcgggca atgcggtttg cccgctcgcg cgtacagcag
     2581 cctgaggtag tcgtagacct cggtgatggt gcccaccgtc gaccgagggt tgcgggaggt
     2641 ggacttctgg tcgatcgaca cggcgggcga aagcccctcg atgaaatcga catccggttt
     2701 gtccatctga ccgaggaact gccgggcata ggccgacaac gactcgacgt aacggcgctg
     2761 gccctcggcg aagatcgtgt cgaacgcgag gctcgacttg cccgaaccgg agaggccggt
     2821 gaacacgatc atgctgtctc gcggcaggtc gatgtcgacg ccgcgcagat tgtgctcgcg
     2881 ggcgccgcga actacaaggc gatcagccac ccgaaggtcc cttcactggt gtgtggaatg
     2941 ccgataagga ccggccgcca ccatgctagg tcgcaccacc gacagaaacc gccggctccg
     3001 cgttcgccct ggtcgggacg gcgaccgcgg agttggtccc gcgagtgcgc ggcctggtca
     3061 gcacacggta cgccggtcgt tcgacgagga ctgtcagcag ccaggcggcg acgaccacgg
     3121 cggtgacaat caccgtcaag cgtaaccacc acggaccgaa accggcctcc gagagccacc
     3181 tcgcgagtac gtagccgagc tgctggtgga ccaggtacag accgaagctg atcccggcga
     3241 gccaggagat gggccttcgc agcaggcgca cgaccggtac gtcccagtcg ggccccttcg
     3301 cggcgaggca catgagcacg agcatgacgg cgagaccgat cacggaggcc acctccggcg
     3361 cgctcgctct cagcgcgtgc aggccgaccg cggccgacaa cagcatcacg agctggagcg
     3421 aaggcagccg gtcgtgctgc cacagccaga tcgccatgcc ggcggcgaac agatggccgt
     3481 agaacgttcc cgtcgccgtc ggcacgctgc tcatgaacag gctcagcagc ggggaggcag
     3541 ccgagatcgc ggtgacggcc cacagcacgg tgtgcgggcg cacccggtgc cgcagtttgc
     3601 tccgccacaa cagcgccgcg cacacgaagg cgatcacctg caccggcaat gtccagtagg
     3661 agccgtcgat ccggtggacg aggtcgggat tccactcgtg cagcaacagc acgttcagca
     3721 acaggtcgtt gaggtccggt acgtgccacg ggaactccac cgtcggcaca gaggggcgga
     3781 ccggatcgcc gaacagcatg ccgagcaccc ccggctggtg ccaccagccg ttgaaggtca
     3841 ccacggcgta gcgggtgacg cagtaggtca gcagtaccgc gaccaggtag gcgggcagca
     3901 acctcgacag ccgtgccctg agccagcggc ccgcgtcgcc cttgcggatc gtcggaccga
     3961 tgaaatagcc ggaaagcacg agcagtgtca cggtcccgaa cgggatcgcc agcgagaacg
     4021 ggtatccttc gatgccggga attctgctcg ccaggccggt cacgtgcccc gcgatgacga
     4081 agaagatcgc gacgaccctg atgacatccc agctcatctt tcgcgacgag gtcgcggtgg
     4141 caggggctgg cgtcgcggtc aatttctttc cccagactcg acttctgcgt ggaaggcaca
     4201 ctaaccgagc tgggcaggcc ctcgtaggcc gggtggagcc atcccgtcgc tctccgcagc
     4261 gccgacgcgg aagcggtgtg agcaggatcg ggtattcgcg ctcacccgag ggccgctacg
     4321 gtgtctgggg tgaacgtcgt tgatgagtac accgggcacg tcgaaccggg aggggacgcc
     4381 acgcggcgca ccctcgacgc gctgaccatc tccaagttgt ccgtcggtcc catggacaac
     4441 aacgcctatc tgctggtgtg cagggcgacc aacgaggcgt tgctgatcga cgcggccagc
     4501 gactcggaac gcatctccga tctcatcggg cacggtcccg accggccggc gctgcgcacg
     4561 gtcgtgacga cgcatcagca tcccgaccac tggcaggcgc tcggcgcggt cgccggggcg
     4621 aacggttcct acaccgcggc acaccccgcc gacgccgacc cgttgccggt tcctcccgac
     4681 catctcgtcg agcacggcga caccctcagc gtcggtgact gcacgctgga ggtcatccat
     4741 ctgcgcgggc acacccctgg ttcgatcgcg ttgctgtacc gggacaagga acggccacac
     4801 ctgttcaccg gcgactcgct gttccccggc ggggtaggca agacgaactc ggccgaggac
     4861 ttcacgtccc tgctcgacga cgtcgaacaa cgcgtcttcg cccagctacc cgacgagacg
     4921 tggttctacc ccggacacgg agacgactcg acactcggcg aacaacggcc acacctggcc
     4981 gaatggcgcg aacgaggctg gtgagcggag ccgctcgtcg agtctgccgc cgcgacatca
     5041 gcgcgtcttg gcggacacct tccgcacgaa ccgctcctct ggccagaagg tgtctcccag
     5101 catcagctga tcgaaaagaa cgcatacggc tccgggggtg tcctcggaat cccagacggc
     5161 cgacacggtc cggccgcgct cgttgccgta ccggctcagc caaaagattc tatcgcccgg
     5221 cctgagttgg aaggccaaca ccaactcccg gttcaccaac ctgcgggtac tcggttgtcc
     5281 tatccgcgcg ccaaaaccgt attccgcagt cggccggggg catcgccaaa cgatccggaa
     5341 ctgctcgtcg atcggcagcg aaggcgaacc cacgcgtact tccttgacca ggtagaacgt
     5401 gacgagtcgg cgtgcctttt ccgacatctc gcgccacggt gttgagagcg cttcggcgtc
     5461 ggcctcggca tccgactcca actctctgag agtagtgatc agctcgtgat cggccgtggt
     5521 gtcggtgcgg actttctgga tcgcccgggt cagggcatcg ggttcgatcc aaagacggtg
     5581 ttcgattcgt ctggcgacat agttgtcacg cgcgtcgatg ttggtgtgca gcggcggctc
     5641 cccagcggcg ggttcgcgag cccattgagc cgcgtcgata caggcctcca gccaatgcgc
     5701 ctcagccgtg ttcagaatcg tttgcgccac tccgggcgcg cgaggcagca agcctggtcg
     5761 accgccggga tggaaatgct cagggccgaa gtgctgcgga taccagtcaa ggtcgctgtg
     5821 gagcagcgtc gcgaagccct cacctctgcg ctgccagaag atcagatcct cgccgtacac
     5881 gttcacgtgg tgctgcacga tgtccgatgg accgaactcg acgcctgccg tctcgcccag
     5941 ctgggcctgg atcacccggt tgccccggta gaggctcaga tagtgcctga cctcggcgac
     6001 gaagtccaca atggaattgt cggccaactg ctcgttcggg ctaatggtga tcgtcttgag
     6061 cacttcgccg tcgcgccgtg ccgaccgcag ttccttggtg gcattgaccc agtagagacc
     6121 gccggtatcc ggatcgtgca cgacgcagag caccggaatg ttgccgttcg cccaggtgtc
     6181 gccgtggtct ccgaccggca cggcgtaacc gtcggccctg cgccacgaac gaccgccttt
     6241 gacctggatc ttgaccagat ctccggcgac ctcgccgttc tcggtgaacg tgacgtgcag
     6301 atcctcaccg aagtcgttct gaccgtccac ttcctgaacg atgtgattgt gtcgctccag
     6361 aagcgtccgc agcgcgttga ccgccgcgcg gccggccctc cgagcgtcag gcactttcgg
     6421 cacgggacct ccagatcatg gcgcgcgatg gggtcgggcg gtcccgacat gcccagccgg
     6481 acgcggatct tactcagata ccgacgacct cgaccatatt gcccaatcct gtgaagtcgg
     6541 cttcgttccg cgtatacaag ggcaacgctc gcgacgacgc gatggcagcg atcatcagat
     6601 ccattcgccg aggccggggg tcccggttcg ccgcgaggac cagcgcgacc aacgttccat
     6661 accgggcagc ggcatcaccg tcgaacggaa gcggggcgaa gtccacgatc gcggcaccga
     6721 gcttctccgt gcgcgccgcg cgaacctcgg cgtccttcgc catcgccacc ccctgatgga
     6781 gttcagccat ggtgacagcg gtgagctccg gaatcttcgg cagtgccgag gagtcgagca
     6841 gaccaagatc aatgtaggta caggtgtcga gcacacccgc ctcgtgacgc tcagccacgg
     6901 tcgcgctccc acgcgtcgtc aggatcaaca cgatcttcgg taccgaagaa ctcgtcagcc
     6961 tcttgccgca tctgggccgc ctcgaccttc ggtagccctc gatgcctttg gaccaactcc
     7021 tctgcggtca ggcgccgcct tcgaggtacc ggccgcagct ctgccacctc gacgccgttg
     7081 cgagtgacgt ggtagatctc gccggcctcg acagcatcca tgacggcagc ggagttgtta
     7141 cgaaactcgc gctgggtaat taccttcatg agagttagtg tagccagatg taactcaatg
     7201 agctacacct gggcgaacag cggcctcacc tggccgattg acgcgatacg tcagaggctg
     7261 gtgaacaggt agacgatccg cggtcgtgac gacagactgg ttgctcgcac ggtagtcacg
     7321 gtcagtcact gggggcacga tggcgatgcc caattttcaa tacgcgatgc tgcccattct
     7381 gggatacacc gtcgatggaa acgtacattc gtggcgactg atccgagacc actgcgcgga
     7441 gcagttcggg gcgaccgacg aagaattggc cgatcggctg gacagtggcg gcggccggtt
     7501 cgacagcaga gtccaatggg ccatcacgca cttggtccag gccggccttc tcgaccggcc
     7561 acgacgctct cacgtccggc tcacccagcg ggccgcgacg ttctcgccga caacccgaag
     7621 agagtcgaca tgcagttgct ctcccagttc atcgagtatc aggacttccg taccaggacg
     7681 atgggcgaca aggtcggaaa gaacggtgaa gctggcacgt cggccggccc cgcggagtcc
     7741 acgggtgaac acccactgga agcaatcgcc ggagcggcaa gggcgaacaa cgcggcactc
     7801 gccgacgaac tgctccgacg aattctcgcg gaggaacccg cctttctgga gcggcttgtc
     7861 ctgaccctgc tcaccgcgat gggttatggc ggcagagccg gtgtcgccga gcactggggc
     7921 cgacctggcg acggaggcat cgacggcgtg gttcggcagg acgtgctcgg cctcgacagg
     7981 gtctacatcc aggccaagcg gtacacggct ggccgaactg atggttctgc acaacgtcgg
     8041 cgtgcaggac gagagcgtct ttgttctgaa gaaggtcgac gaggacttct tcgaccagcc
     8101 gtgatgggct ctaaccgaca aaacgccgaa gcggtagctc gtctcctacg acgcagtgag
     8161 gctcagtcca caagccacag tggacggtca cgtcagccac ctggccgggt gagaatggca
     8221 tggacacacc atccggggcc acgcgaaccg cccggttcag gcgccgcgtt cggaatggtg
     8281 cggttcatga catcttcttt cgcaccggcg ttcgtcgccg cgctcatgac ggccacgacc
     8341 gcgctgacgc cggcaaccgc cgaggcggcc gagcagcccg tccgcttgct cggcgaggcg
     8401 atcatcccgc acaaaatgga ctacgagggc accaccgtcg ggggcctttc cggcatcgac
     8461 cgcgacccct gcaccggcga gtacgtcatg atcagcgacg accgctccta ccagcagccg
     8521 gcgcggttct acaccgccgc catcgacgtc gacgcggccg gcgtgcacgg cgtcgacatc
     8581 agcggcacgc acgcgctgag gcagccggac ggcgccacct acccttcgcc gacggcaaag
     8641 gacggcaagg ccgtcgatcc cgaggagatc agggtcgacc cgtggaactg ccaatactgg
     8701 tggagccagg aaggcaaccg ccccaaggat ctcgcgagtg acgagccgtt gatccagcct
     8761 tccatccaag cctcgacgag gcacggcggc tacctgcgct cgctgccgct gccagccgac
     8821 tacacgatca cgagggacga gcaggggccg cggcgcaacc tcgtccttga ggcgatcacg
     8881 ttcgaccgcg gcggcgccac gctcaccagc gccgtcgagg gaccgcttgt gcaggacggc
     8941 gaggaaccga cgaccgagca aggcgcgctc accagggtca ccacgcagag ccgttccggc
     9001 gaggtgctcg cccagtacgc ctatccgctc gacccgctct tcgccgaggc cgacccgacc
     9061 agtccgtgga gcccggacac cggggtcccc gcgattctgg ccgatccgga cgagcccggc
     9121 cggtacctgg tgcttgagcg cacctacgtc cccggcgccg gtttcggcgt gaagatcttc
     9181 accgccgacg tccgtggcgc caccgacacc aggggaactc gctcgctcgc cacggtgggc
     9241 atccagccca tgcacaagga accgctcgtc gacctcgcgg accttccact gtccactgtc
     9301 gacaacgtgg agggcatgac ctggggtccc gacctgccga gcggggaacg cacgctggtg
     9361 ctcgtcagcg acgacaactt cgcggaggag gaggtcagcc aggtgatcgc gctcgcggtc
     9421 ggctgagctt gctagggtcg ccgggtggct gacagcgggg cgaacgtcgt cgagatctac
     9481 accgacggcg cgtgcagccc gaatcccggt ccaggcggct ggggcgcggt gttgcggtac
     9541 ggcgatcacg agcgtgagtt gcacggcggc gaacctgcca cgacgaccaa caaccggatg
     9601 gaactgaccg cgcccatcga agcgcttgaa gcgctgaccc ggccatcggt cgtcgctctc
     9661 tacaccgaca gcagttacgt ccgcaacggc atcacccagt ggctggcccg ctggaagagc
     9721 aacggctggc tgacctcggc gagagaaccg gtgaagaacg ccgacctgtg gcagcggctc
     9781 gaagccgccg ccgcgccgca caccatcgaa tggcactggg tcaagggaca cgcgggacat
     9841 ccggacaacg agcgggccga ccggctcgcg gccagcggaa tgagggaggc gctcggcgcg
     9901 cagggcgacg cgccgagcgc ctcctccccc agcactcccg tgaccgccac cggctgagcg
     9961 ggccacggat cacggaccgg cggctgaacc cgatcagccg tcagcccgcg ccgagtaacg
    10021 tgccgagcct tgccagttcg gttcccgggc ccgacggcag gaaactccgg tcgcggcggg
    10081 aaatgccgcc cgcgactcgg cgcaattcct gctcctgata gcgaacgcat ttccggtgcc
    10141 attcgaggat tccggacatc cagttcttga aatgctcgac gtgtccttcg agcgcttctc
    10201 tcaccggctg ggctagatcc agttcggcac acatcgcggg gaggtcgacg tcggcgatgt
    10261 gctcgaactg ttcgagtctg gcgtccacga gccgcaccac gatgtcccta gcacgggccc
    10321 tttccacgtc gaggaagttc tccacgacga gcaccatgtt gtgcagctcg ccctcgaact
    10381 ggatctcctt ctggtaggag aacaggtcgt tgacgaacat ggcgaagtcc tgcgccgccg
    10441 tgtccagttc gtgcaatacg cggttgtgga agagttcttc cgggacgatc gccgactcgg
    10501 tgagccttga cagcgccttg gtcatgtccg acccgaaggt cttcctgcgc atctcgacgt
    10561 agtcgatggg gtcgggaatg cggttctggg cttggttgat cagttcccac agccaggcgt
    10621 cgagcatgtc gtcgaccgtg tcgcgaaacc gcgctcgcgc cggatccggc atcgggcccg
    10681 ccgttcgcag ccacaggtcg gccagcccgc gttcgagccc gttgaccggc tcggccgggc
    10741 tttccaggtc gagcggcatg aacatcttga gccgctccgt ctgcgccttc gcctcgggaa
    10801 ggtgtctccc cgcgccgaag acgaccgggt agtagtcgtc accgtaggtt ccccacgcca
    10861 gccagtgcga ggcgaggttg agcgcgtcga gatcggcgcc ggggtgcagg ccggacgcgc
    10921 agtgcggcag gtcgattccg gcgcagcggt cctcgtccca cacgccgccc gcttccaccc
    10981 ctggcaagga gtcgtagaag cccatctccc tcgcccacgt gatcatgtcc gccctcgact
    11041 ggtcgaggtg cggattgacc cgcgcggggt agggcatcct gatctccggc agttcgagat
    11101 gccccaccgg ctggaacgga atgtgggagt gcctgcgcac gcgctgccgc gatcccggca
    11161 gcagcgacag ccttcccgcc gacgtgccga ggccagaaag cccgccgaca ccgggtttct
    11221 cggctccctc gttcatgtat ctgcttgagc gcgcatgcca ttcgtgcccg cctgcctgcc
    11281 agtcctgcat gcctttcacg taggcggtga cgcctgcctg accgtcgggc ggaacggcgt
    11341 actcggcgaa cagcgcaggt acctcggtga gcgccgtgtg ctcgaactgg tgcaggcggg
    11401 aggtgagcag gtcgttgacc aactcggccg cgtcctgggt cgggcagtcc agaaaggact
    11461 cgaagacgag taccgcgttg gagttctcgc cttcctccct cacttccctc tgataggaga
    11521 acaggtcgtt gcgcaggtgt accgcgtcgg cgaaagtgtc ggtgagcacc cgcatcggtc
    11581 gcgtcgcggc gaggttgtcc ggtatttccg ctccgacggc gtactcgacg agattcgccg
    11641 accacggcgc gccaccgact cttctgcgca tctggatgta ctcgatggga ttggcgatcc
    11701 tgccgcgttc gatgttctcc agttcccaca tggattcgac catcaggttg tgggtgctgg
    11761 tgatgaagcg acgccgccac ccggccgaca tcgacggaat ggtgcgttcc cagaggtcct
    11821 tgagcccggc ctcggcgggg ttttccggtt ctggcggagt ttcgccgtcc tcggtcatga
    11881 acagttcgag gcgatcgagg tagtgtctcg cgcccgcagt gtcgcgggag tacttgaact
    11941 ggtcgagaaa gtggtcgtcg aagaagaaga cccagacgta ccagtcggtg atcaggtcta
    12001 gctcgacgcc gccgcagtcg ggatgggtgt aggcgcacat gagagcgtag tccatcgcgg
    12061 cgagttcgtc ctctgtccac acgacaccgc cctggtgagc ggcggcgtcc agcatgccca
    12121 tccgctcggc ccatgccatc gtgtgttctc gcgaacgttc gaggtacgga ttgattctcg
    12181 ccggataggg caagtagaag tcgggcagcg tgaatgcctg catggaaggt ccctgctccc
    12241 ctcggggccg ccgatcgtgg tgctgtcggc tctcaacgct gtcaccggcg gtggtgtgcc
    12301 gacaacagcc ggctgagcga tccggggtcg ccatggaagg aattcaccga tccgctggtc
    12361 ggcgtcgtcg tggcggcggg aactgcccgc gacgggcacg gagggtcacc accgggctcc
    12421 cccgcccggc ctcacccgtg cccccttcgg gcagacaggg cctaggtttt gctctgatcg
    12481 ttgctgagcc agtacctcgg gcgcatacgt accaggatcg accggtcgcc aaggtccgtg
    12541 ccgacatagg actcggcatc ggcctcgggg agataacggc ccgcgatcgc gagcgcctgc
    12601 tcgcgggacg gcggttcgcc gttgctcacc acgggccctt cggccgtgac ataccggtag
    12661 ggcggggttt ccgactgtac gacgaggctg aacctgcccg ccgcggtgat cgccttgtcc
    12721 ttgacggtgt cgcggtccat ccacaccacg acgtcgccgt catcgacgtc gtaccacacc
    12781 gggacggcga gcggcgccct tccgttccgt tccacggcga ggatgccgac atgcacatcc
    12841 gcgaggaagg actcccgctc ctcggctgtc atcacgaacg acatcggcaa cactccctga
    12901 ctacgcggac aatcatcgtt accaacatcc gccggacgga cctcattccc gtcgccgaga
    12961 atcagctcac cgcgcgtgcg tagctctcgc gcagcgcctc ggtgcgctcc gagggccacg
    13021 ggcagcgaac gtctccggcc agcgcggcga acaacaactc cagatgtgtc tgccatgccg
    13081 cgagcaacgt ggcacggtcg gcttcgctcg cgaagggaac gtgctggctg agcacgagcc
    13141 tcgtcccgat cgggagctgg tcccgcagtt cgaacctcac cctcccgctg tccgaggagt
    13201 cttcgggaac cgcgtattcg agcacccgcc ccgggacggc ctcggtgatc gccccggtcg
    13261 gctggtaacc atgggtgaag gcgacgggcg gctcggtgcc gggccggatc tccccgtctc
    13321 cggcgagcag ggtccacacg tccgatatag acgaaacgag gtcacgctcg aacgtgatca
    13381 gccagccgtt gccttcgtgt tcgatgcttc cccgcgcgag gccgaaccgc tcgacgtact
    13441 cctccgccct ttccaggaac cacgctccgg cggcactttc ccggttctcg ccggagagca
    13501 ggcagccgag ccggtcgagg cagccgtccc agccgggagc ctgccgagcg accgaaggca
    13561 ggtcacccga ggtgtcggtt ccattgagaa ggtgggtgaa cacgagggtg cacccgcctt
    13621 tcatcggcag cagttcgaag cggagcagcg aatcggccca gctgaacgcg aaaacctttg
    13681 gccggtcgaa ctcgacgacc tcgccgtgcg cgaaagcgtc gtccgcggcg ggaaaaccga
    13741 accggatcgg cgcacgggcg gcaggctcga agtccggctc ggcgggaaac cagtgcgcca
    13801 gctcggccgg gtcggtgatc gcgcgccaca ctttctccct cggatgcggg aacgtccttt
    13861 cgaagcgcag caaaggtttt ccctcgacga gggtcaccgt gccgagtcgc tgattcatgc
    13921 tccgtccttt ctcatccctc cgcggcagcg ccggacacga cccggtcgag cacgtcgagg
    13981 caggcgagcc atccggtctc ggtctgcgcg gcccaggtgc tgtcggcgaa ggaatgggtg
    14041 aaccgcaata cgcacccttc ggcggtgccg gtgagctcga agcgaaggag gtgaacgccg
    14101 gtctcctcgt cgaactcctc gaaggcgaac gctttcggcg gatcgatctc ggtgacctcc
    14161 gccctcacct cggtgccttc gtcgtccctg aacagcagcg tcccgcccac cgtgaagttc
    14221 cattcgacgg ccgcgaaggg ataccactgg ctcagctgct cgggttcggt gatggctcgc
    14281 cacacggtgg atggcgggtg ggcgaagttc cgctcgaagc gaagttccca gtgttcgcct
    14341 gccttgtgaa gagcgttgtt cacgactcac gttcctttcg tgcattgtgg actgtctcgg
    14401 ccgggccgtc ggacatggtg tcgagatgac gttccagttt gtccagcgcg tcgtcccaca
    14461 gcctccggta gggcgcgagc cagtcgtcga tctcccgcag cggccctgga ctgatccggt
    14521 accagcgccg ctgcgcgtcg tggcgcacgg cgacgagtcc cgcctcccgc agtatccgca
    14581 ggtgtttcga caccgaggac tgcgggatcg gcaaccgttc gacgaggtcg ccgacgaccc
    14641 gttcgccatc ccggagcaaa tcgaggatct ccctgcgccg aggttcggcc agcacctcaa
    14701 acgtagttgc catatgtgga atatatccgt acgggaatat acgcgcaacc cggctcagtg
    14761 ccactcgcga aaatggctct tgatctgcgg agtcacgctc gaaccgtcgt agtacttctc
    14821 gtagaacgcg gggtcgacgt ggtgcacgac cgcgccgaag ttgcactgca tggggttgaa
    14881 gtacaccggg gcctggccgt agtgctcgac gcaatagtcg aagcaggccg cgcaagcctc
    14941 ggccgcccag tcactgatcc gcacggcagg actttcgacc agggcacgca cggtctgctc
    15001 ggtataggga ccgtgatgcc gcagcatcca gttgtcctcg cccctcgaca tcgtcgcgcc
    15061 atcgccgtac ttctgttcga gcatcgccgc caccacggcc gtaccgtccg gatacgcggg
    15121 cgagggaacg taggtcgctt ctttcacccc ggggacaccg aacgtcttga gcgcgccgct
    15181 cgcggccggc gcgcgctcgt tgagcggctc gtgcacgaac ccgagcccgg gagtgacgtc
    15241 ggggaacgca cccatgagca catcgtcgaa gaaaccgcag aagatccagt tgccgaggcc
    15301 gagggcttcg gcggcgagcc gcatgttctg caccatcgaa ccgggaggat aggtctccac
    15361 ctggaagatg aactgctcga actggctgat cgtgatgggg aactccagtt tgccctcacc
    15421 gacccatttc gacgtccccg ccggcaggcc cgtccggtcg tcgacgaggt agacgtgcca
    15481 ggcgtcgaag atgttcagca acgcgctgaa gtagagccag ccgacgtcgg tgaccgggac
    15541 gaaccacgtc gtgccttctc tgttgatgtt gtactggtaa gggccgaaca gcgaggcgtt
    15601 cggcgcaccg ggagccctca gtgcccagtc gatgtccggc cgtccatcgt ggaccttgcg
    15661 aagtccggtc cggtaccagt cgagaacctt gtgatagtcc ttctcacctt cgatctcgac
    15721 catgcgttcc cgttcggtgc cgggatcgta gatgaacgcg ccctcgtcct tcaccacgag
    15781 cagatcgtgc gcgaaggagt tgccggggcc ggccgccgtc cttccggcga tccgcaccag
    15841 ctcgtgaaag ccgccgctgc tggcgatgtc ccagtgcgcc atcccgttgg gcccgcatgc
    15901 cgcccacgcg acgatcgcct cctcgacctc gctcagcggc acgaccggat gctccgacac
    15961 gaacgcgagc ggaccgcgag gctggaacag ccgccgccct ccccgcgagg tctcctcggt
    16021 tccgctctcc atccggtagc ccatcgcgac cctgcggctt cgcaacgtcg ccagcagttg
    16081 cgggagcgtt ctcgttccct cgaagaattc cttgagctgc cgctgctctg cctctgttgc
    16141 cgccgcctcg ggtcgtggtg cggtcgtcgt catcggtttc tcctccgtgg tgggtcgagc
    16201 cctgcacggt cactgccgtt ccagcgctcg ctgcacccgc aacgcgagtt cgagcaggaa
    16261 ccgttcgttc acatcacgca ggcttacgcc gagcatgtgc tgcgccttgg cgagccggta
    16321 acgcactgtg ttgggatgta cgtgcaggtc ggctgccgcc cgttcgaggt gccggtcggc
    16381 gtcgagatag gcgtgcagcg tcctcacgta gtcggtaccg cccgcggtgt ccgcttcgag
    16441 tagcggcccg agtgcgctat ccacaatgga ctcaagcgat tgtctgctcg gcgccctcgc
    16501 gagcaggccg tacaaaccga ggtcgccctg cgccagcacc tcacccgctt tgcttccgcg
    16561 ccgggcgatg tccagtgcca gcaccgcttc cgcgtaggaa tcggggtagt cctccagcgc
    16621 caggcacaac ctgccgaccc cggcgacgag gtcgagccct ttcccttcct cgggaatcac
    16681 gccctccctg agagttttga gaaccagccc gagatcgtca ccgtccggtt gcaagagcac
    16741 gacgacctca ccggcgcggg gattgaccat cgagcgcggg tagtgcctgc gcaccttctc
    16801 ctcgacatga atgaacatgc gccgggtcag cgtcggcagc gtgctcgcct gagcggcatc
    16861 ggcaccgccg gggtccttgc cgttcttggc gctgatacac acgacgaagc gcggttcggt
    16921 gagggcgacg tcgagcaacg ccgccctcgc cagcatgtct tccctgtccg tgaacctgcc
    16981 gagcagaaga ctgtcgagga attcactgtg caccctggat tccgcgcgca gcgcggcacg
    17041 ttccctgagc aactgcaagg tcaccagata acccgacacc tcgacgagtt cgcgttcact
    17101 gcgctccggt tcgcgcgtgc cgctgacccg cagtatcccg aacggctcct cccccacccc
    17161 gacctcgacc ctcaccggct cgctgtcgtc gtcgcccggc ggggccttgt acaacggccg
    17221 cccgtcggga tccagcagcg cgaccgacat tccgatgtgg tgggccagca cgccgatacc
    17281 cgcggaaaga tcctccgtgc gcacgagact catcgcgatc gccccgagta cctcgacggc
    17341 gcgggttccc gcgtgggcgg cccgctcggc cgtctcgcac cgctcccggt gcaggtgccg
    17401 ctccctgatc tgggccagcg cgacaccggt gtcccttccg atgtcggtca gcaatcgcag
    17461 ttcggagtcg gtccagtccc tcgggcgacg gtccgccgcg tacagcacgc cgagtacgtc
    17521 gtcgccgcac aacaacggcg cgcacgcgcc gccccgcaca ccttcggcgt cgataatgga
    17581 cttcatgacc ggaaccctgc gcggatccct gcgatagtcg cggacggcga tcgttcttcg
    17641 ttccttggcc actctgccgc cgattccctg tccgacggcc aaatgccaca gcgcgggcat
    17701 ctccgccgtg cgaaggccac cgtaggcggc gagcctgatg tcgtcgccgc tgacgacacc
    17761 gctccagctg atctcggccg gcagcacatc gcgcacagtg tccacggccg cctgagccgc
    17821 cgcgctgaca gcgctcgccg aaagcagcct gcgtagcagg ccctctagcg ccatcaggga
    17881 agactatgcc tcgttccacg gttcgtcact atcgggaatt gaaacgggac gctcagcgga
    17941 ctgtcgtttt ctgccaaagc ccgagctcag gttgggctgc aaccgacatt gcccgcgtgg
    18001 ccaccacgtg acacggtctt ttcattcggg aacgcgagca cggaacgagc gaggagggca
    18061 caatgccacg accacgcagg gtcgtcgaag aactcgtcag agcacgcgcc gaagctcatc
    18121 ccgacaccgt gtggctgaag tggcttgacg aggaaatctc ttggctgaca gcactttcgt
    18181 tgagcaagcg agcggccaat ggactactcg aactcggggt acgccccggc gaacgggtcg
    18241 cgcttctgct gcccaaccgg ccggaattca tctggacaca cctcgcgatt cagataatcg
    18301 gcgcacattc ggtcccggtg aatatttcgc agcgtggtgc cactctcgcc cacattctca
    18361 ccgattccgg cgcgtcggtg atcgtttttc acgacaaact ccgcgacgcc gttctgtcag
    18421 tccggcaccg gctgccctcg gtgcgacggc tcgtcgtgtg cgacgggccc gccggtggag
    18481 gaatcgactg gaacaccgag cggctgttcg cctgcgccga caccgaaccc gaaaccggcg
    18541 ccgcgacgag cgaaaccggt gctggttcgg gtgtcggcat gatgtacacc tccggaacga
    18601 cgggccctcc gaaaggcgtc gtcacggccg actacgacct gcggccggtc gaggcgctgg
    18661 tgcgcgcggc gggggtccgg ccaggcgaga cgatgtacac cgggctgccg ctgtttcacg
    18721 gcaacgcgct gctggtttcg atgctcggat ccatcttcgc cgacgccaag ctcgcgctcg
    18781 cgccgaagtt cagcgcgtcc cgccttctct ccgactgcgc gcgatacggt gccgtcgagt
    18841 tcaacacgct cggtggcatg atctcgatcc tgctcaagca gccaccgagt ccgctcgacc
    18901 gcgaacacga ggtcagggtg gtgctgtcgg ctggttgccc agccaaccgc tggcgcgagt
    18961 tcgaagaccg gttcgggatc aggatcgtcg agtggttcgg catggtcgat tcgccgggaa
    19021 ttctgctcaa cgacacggga agagtcggtt cgatgggcag gggcggtgtc gcggggatcg
    19081 agttcagggt cgtcgacgac gccgaccggc cgctgggacc gcaggaggtg ggcgaactcg
    19141 tgttccggca cccccgaggg gcgacgacga gctatcacaa cctgcccggc gccacggcgc
    19201 gcgcctaccg cggcggctgg ttccattccg gcgatctggc cgactacgac gaggacggtt
    19261 tcttctacta ccgggggcgc aaacgcgagt ccatgcgcag actcggcgag aacgtgtcgg
    19321 catgggagat cgaatccgtg ctcaacaccc accccgccgt gctcgacagc gcggctcacg
    19381 ccgtcgcctc cgaactcggt gacgaggaca tcaaggtgtg tgtcgtgctc cgttccgcct
    19441 acgacgccga gccaggcgaa ctgctgctgt tctgcgtgga gcggatggcc taccacgccg
    19501 taccgcgcta cgtcgaattc ctcgaagcgc tgcccaaaac ggccaccgag cgcaaccaat
    19561 acgcgacgct gagggagcga ggtctgacac catccacttg ggacagggaa acggagggga
    19621 gctcatggct gaagtccaga tcgccggcgc ggccatgacc cggttcggaa agttcgcgac
    19681 cagcacgatc cgttcgcttt cggaggaggc ggtcgccgcc gcactcgccg acgcgggaat
    19741 agcggcccgt gacgtcgacg ccgtgttctt cggaaacgcc gcggccgggc tgctcaccgg
    19801 tcaggaaatg atcaggggcc aggtcgcgct gcgcaacacc ggactgctcg gcgtcccgat
    19861 cgccaacgtc gaaaacgcgt gtgccacggc ggcgaccgcg tttcacctcg ccgtgacggc
    19921 tgtccattcg gaggtggtcg acatcgcgct cgccgtcggc gcggaaaaac tcactcacgt
    19981 ggacaaacgg cgctcgttcg ccgcgctttc ggctgccgtc gatcttttcg ccttttccga
    20041 attgtcccgt acggtcccgg tcacgcaaga atcggccgca ccgattcggc gaccgaaact
    20101 ccattccgtc ttcatggacg tctacgctgc cactacccgc gcctacctgg cgcggtcgga
    20161 cgcgaagcca cgcgatttcg cggaggtcgc cgtgaaaaat caccggcatg cggcgctgaa
    20221 ccccaaggcg cagtcccgcg agcgggtcac cgtcgagcag gtgctcggca gtcccgttgt
    20281 cgccgcgccg ttgacgatgc tcatgtgctc gccgatcggg gacggtgccg ccgcgatcgt
    20341 cgtgtgctcg gcccgcaggg cgaaagccct cggcgccgca cgagtgagag tcagggcgtg
    20401 cgctctggtg tcgggcacga cgagcgcggt acccggctcg cgcgtgcgcg cggccgcgca
    20461 cgcctacgaa caggccggtg tcggcccctc cgacatcgac gtactggaac tgcatgatgc
    20521 ggcggcacct gccgagctca tcggctacga gcacctcggc ctgtgcgggc agggcgaagg
    20581 cgccgcgctg ctgcgctcgg gcgccacccg gcttggcggc gcgcacgtgg tgaacccctc
    20641 cggcgggctg ctcgcgaaag gccatccgat cggagcgacc ggatgcgggc agcttgtcga
    20701 actcgccgac cagcttcgcg gccggtgcgg accgaggcag gtgcccgggg cgcgcgtggc
    20761 gctcgcggaa aacggtggtg gcctcatcgg cgaggacgcg gccgcgacgg tcgtcaccgt
    20821 gctttcgacg tgaaaggacg aacaatggag ttcaagcggg tgatcggcac gcggcgcacg
    20881 atccggttct tcgaaccgaa tcgtgccgtc gagccggaga agatccagat catgctcgaa
    20941 gcggccaacc gggcttcccg tgcggtcaac gccgatttcg tcaaggcgat cgtgtgctac
    21001 cgcgacgaac tcaccgacga ggtgcgggag caactgaaaa cgcccacgac gacggtgcag
    21061 ctcgatctcg cccctgtcgc gatcttctgg tacggggatc ttgcattcgc cgacaacgcc
    21121 cagtccaggc tgaaggaact ggtcgatctc ggcgcgttgc cggtgactca cggatggtca
    21181 cacagctacg tggacgacgt cgccgtcgcc cagtccgtcg aaccgatgtc gaaggacgcc
    21241 atggccagca cctgggcggt gtcggtcgag tcggggctcg ccatcgcgca ggcgatgctg
    21301 gctggcgtcg acgagggact cggcgtcggc ctgcactcgt tcgaagccga gacggccaag
    21361 gccgtgctca aggttccgga caactggatt cccatgtgga tgttgctggt cggctatccg
    21421 gccgaaagcc acgaggcggg agggcagcgg ccacggcgcc cgctcggcga caacttccac
    21481 cgcggtcagt acggctcgcc gtgggacgag attcccgagg tcaccgagcg gctcaagaag
    21541 gaaggcatga tccaggcgcc catggatccc acgctccggt tcgccgagat caggcggctg
    21601 gccgagcgct tcgggctgcc cctgtgaaca cgctgagcac cggagccttc tccggcgacc
    21661 ggtcggtgcg gcactggctg tccgaattgg agccataccg cgaaggcagg gcagcgacca
    21721 gcgctcggct cgccgtgctc ggtgcgttct gcgcgcacgc gggcaaatcc cccgacgagc
    21781 tcgtcgcctt ctgcttcctc aggaaaaaga cgacggggca acggtttctc agcggcgcca
    21841 ggcggcgagc cgtcaacggc atgctggaga agttcgtcgc cgagcagggc tggatcggca
    21901 aggaagcggt cagcaacacc aacgtcgtca gaagcttcct gatccacaat ggaatcctga
    21961 tccaaggtgc cgtctggcgc gggccgtgat gtccgtcaac tccgccgcca cccggtgttg
    22021 agcctgccac cggcgaccag ttccaccgcg atcagcacgg caagcgactc cgcagcgagc
    22081 aggccgacga gaaccagcaa ctgggtgacc ccggcctgca ctgggctcgc gccgccgagc
    22141 agcacgccga cgtaggcgcc gggcagggtc accagcccga ctgttcttgt ctggtcgagc
    22201 ggcgggatca gcgcgtgccc cgc
//
