LOCUS NZ_CP018145 22361 bp DNA circular CON 05-MAR-2024 DEFINITION Brevibacillus formosus strain NF2 chromosome, complete genome. ACCESSION NZ_CP018145 VERSION NZ_CP018145.1 KEYWORDS RefSeq. SOURCE Brevibacillus formosus ORGANISM Brevibacillus formosus Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus. REFERENCE 1 (bases 1 to 6437015) AUTHORS Fu,B. and Li,Z. TITLE Direct Submission JOURNAL Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: HGAP v. 3 Genome Coverage :: 167.68 Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 03/05/2024 02:46:36 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.6 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,168 CDSs (total) :: 5,986 Genes (coding) :: 5,821 CDSs (with protein) :: 5,821 Genes (RNA) :: 182 rRNAs :: 16, 17, 17 (5S, 16S, 23S) complete rRNAs :: 16, 17, 17 (5S, 16S, 23S) tRNAs :: 127 ncRNAs :: 5 Pseudo Genes (total) :: 165 CDSs (without protein) :: 165 Pseudo Genes (ambiguous residues) :: 0 of 165 Pseudo Genes (frameshifted) :: 85 of 165 Pseudo Genes (incomplete) :: 95 of 165 Pseudo Genes (internal stop) :: 22 of 165 Pseudo Genes (multiple problems) :: 35 of 165 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 14:35:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 4761844 Orig. end :: 4784205 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to CP018145.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ This genome has a base modification file available. COMPLETENESS: full length. FEATURES Location/Qualifiers region 1..22361 /candidate_cluster_numbers="1" /contig_edge="False" /product="lanthipeptide-class-iv" /region_number="17" /rules="(cds(LANC_like and Pkinase) and not micKC)" /tool="antismash" cand_cluster 1..22361 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(cds(LANC_like and Pkinase) and not micKC)" /kind="single" /product="lanthipeptide-class-iv" /protoclusters="1" /tool="antismash" protocluster 1..22361 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[10000:12361](+)" /cutoff="20000" /detection_rule="(cds(LANC_like and Pkinase) and not micKC)" /neighbourhood="10000" /product="lanthipeptide-class-iv" /protocluster_number="1" /tool="antismash" proto_core 10001..12361 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(cds(LANC_like and Pkinase) and not micKC)" /neighbourhood="10000" /product="lanthipeptide-class-iv" /protocluster_number="1" misc_feature complement(294..308) /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: weak, score: 20.65" /tool="antismash" misc_feature complement(379..394) /note="TFBS match to CopR, Copper-responsive regulator, confidence: weak, score: 21.73" /tool="antismash" gene 548..964 /locus_tag="BP422_RS22565" /old_locus_tag="BP422_21985" CDS 548..964 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018885325.1" /locus_tag="BP422_RS22565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_21985" /product="hypothetical protein" /protein_id="WP_233220522.1" /transl_table=11 /translation="MFMGKGTVRELGNQIDKVLGDIKDIQAEIDRDSDKIDNELNSCSR ELINAQTTLGEIQPLIESLVAQVGQNAPDHIKVLVGTIADGITGKVKNTLNNLAEVQKN VKDVDKLTDAIDGHTDKIAQKVKEIDSITDKVQK" gene 973..1299 /locus_tag="BP422_RS22570" /old_locus_tag="BP422_21990" CDS 973..1299 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS22570" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="BP422_21990" /product="hypothetical protein" /protein_id="WP_088909596.1" /transl_table=11 /translation="MSYINNSNGWGTQHTNHVANKVDHLADKISFAVDMVANAAINLDG AQQELLTLANAPYPPQSTQLITLANRIAANKRQIDDGLAKIKEMARTIDQETNQIQTPP QKGW" gene complement(1361..3682) /locus_tag="BP422_RS22575" /old_locus_tag="BP422_21995" CDS complement(1361..3682) /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_S9" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017251698.1" /locus_tag="BP422_RS22575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_21995" /product="DPP IV N-terminal domain-containing protein" /protein_id="WP_088909597.1" /sec_met_domain="Peptidase_S9 (E-value: 4.7e-38, bitscore: 129.2, seeds: 64, tool: rule-based-clusters)" /transl_table=11 /translation="MENVVTWEQYERAQRLHPANYYDAVFNAFVRPRWISGSQFWYIRE IRLEKGSGRQYVIVDAEQNTSQPAFDHERLAVCLSGSAGKGYDAETLPLGELMFTESGS AFQFEVGGTVWSCDLQEYTCKPLKNFKKPSMDELPSPDGKWVAFVYDHNLYVRSLETGR RIRLTYDGKAYYDYGTQPECRLSIMAERLNGTKLPPVAIWSPDSKMLLTHRLDQRKVRE MDLIQSVPKGEGVRPVLHSYRYPLVGDQHVPLAELVICNLERRTTVRIESEPLMACPVS PLTQGMQMAGWSSDSKQIYIARMSRDARSVDFSLADPCSGEVCTLLREQSDTFLNQDLH NLGASNPNFRLLADGSFIWHSERDGWSHLYYCDGKTGEIRNPITSGSWTVRRLMAVDEQ QGWVYITGGGLEEGRDPYYQHLYRVRLDGTGLSLLTPEDAEHDVVFSPNLKYFVDTFSR VDLPPVTVLRSVDGSLIRELEYADVEMLLEMGYQFPERITVKARDGVTDLYGVMLRPFP FDPSRKYPVVDYIYGGPQIINTPKAFALDPGRSHDPLGGGQSLAQLGFIVLILDGMGTP YRSKAFHDISNGNLEEAGGLLDHVIAIKQLAERYPYVDVDRVGIWGSSGGGYASTRAIL SFPEFYKTAVSACGNHDQRLYIAAWAERYQGLYDPDLYRDQDNARLAANLEGKLLLVSG DLDGNVHPSQTIRMANALIKADKDFDMLILPNRHHGFSLEPYFIRRKWDYFVRHLMRAE PPWGNQKSYKNTSDKESMEK" misc_feature complement(3634..3647) /note="TFBS match to RpoN, Regulator of nitrogen assimilation and virulence, confidence: strong, score: 17.31" /tool="antismash" gene complement(3886..5478) /locus_tag="BP422_RS22580" /old_locus_tag="BP422_22000" CDS complement(3886..5478) /EC_number="2.7.7.65" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1025: diguanylate cyclase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015893437.1" /locus_tag="BP422_RS22580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22000" /product="sensor domain-containing diguanylate cyclase" /protein_id="WP_088909598.1" /transl_table=11 /translation="MPVLQKRANHPKKISLVTLLTGLVSLSVVLTVTILLLSFYQSKKQ ALINTTLTLNHTSAIKMSHTLDALIKSMRSSLQYSASIFSNRKEMNADEVYSKLELIRR TNNYFNSVSVVDETGLVRGVSPGSIGTVGSYVKTKTGKTALALKKPYISEPYVTASTKR LIVLMSEPIFDKDGFYRGIIGGTIYLHEDNILNTIFGSNPTDELGSSFYIVGSDGHLLF HRDTNRIGEDISANPAVRKLIQGKSGYEQIVNLRGQTVLAAYVKVPANDWGVVVVSPIS VVQEQLNRDIQSILLYMLPPFLLLMLVVIGLARKVAKPFVSLANLVSKAGREEVELSEG GQHWNREAELLSHAIRFALTNIKKQTEQLAHDARTDPLTGLTNRRTLEETMQEWMAEQI PFSTIMMDLDRFKAINDTYGHPAGDEVLRHFAKIISSLLRPDDVSCRFGGEEFVVLVSH AGLEEAYQVAERIRHALETRTNPIGQSITVSQGIAHYPSHAVSPEGLLQLADEAMYKAK RSGRNQTMIAEAE" gene complement(5646..6293) /locus_tag="BP422_RS22585" /old_locus_tag="BP422_22005" CDS complement(5646..6293) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015893438.1" /locus_tag="BP422_RS22585" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22005" /product="2OG-Fe(II) oxygenase" /protein_id="WP_088909599.1" /transl_table=11 /translation="MIGHTTEKERTIFDHTGNRIKTEDREIQILAKYEEPLVVVLGNVL SDSECEELIEHSRERLQRSKIGEDRSVHSIRTSSGMFCEQMETITRIEKRISQIMNIPI EHGDGLQVLRYTPGQEYKPHYDFFAETSRASTNNRISTLVMYLNDVEQGGETVFPLLHL SVFPTKGMAVYFEYFYRNQELNELTLHAGTQVIHGEKWVATMWMRRQSFRVS" gene complement(6503..7849) /gene="brnQ" /locus_tag="BP422_RS22590" /old_locus_tag="BP422_22010" CDS complement(6503..7849) /GO_function="GO:0015658 - branched-chain amino acid transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0015803 - branched-chain amino acid transport [Evidence IEA]" /codon_start=1 /gene="brnQ" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017251695.1" /locus_tag="BP422_RS22590" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22010" /product="branched-chain amino acid transport system II carrier protein" /protein_id="WP_088909600.1" /transl_table=11 /translation="MSQKAPVSFVVTIGFMLFALFFGAGNLIFPPMLGQLAGTNVWIAN AGFLVTGVGLPLLAITAFVYSGKDDLRSLASRVHPVFGMVFTIVLYLAIGPFFAIPRSG NVSFDIGVKPFLSEQAGSAPLILFTILFFAIACFLSLNPMKIIHVVGKILTPIKLTFIG IIAVTAIVYPIGALQAPQADYTSHVFFKGFQEGYLTLDALVAFVFGMIIVNAIKEKGVT ARKQVLATCAKATMIAGLLLALFYTALSFMGASSVEKLGHLENGAEVLAKVSNYYFGSY GAILLGLMITVACLTTSVGLITACSSFFHSLFPKISYKKFAVILSVFSTLVANIGLTQL IKVSVPILMTMYPIAISLLFLTFLHKAFNGRPEVYQGSLLFTFLISLFDGLKAAGVENS VVHHYFTQYLPLYDVGLGWLLPSLIGGICGYMISVFRKNMYHVQKQKEA" gene 8402..8725 /locus_tag="BP422_RS22600" /old_locus_tag="BP422_22015" CDS 8402..8725 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS22600" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="BP422_22015" /product="hypothetical protein" /protein_id="WP_088909601.1" /transl_table=11 /translation="MAFKSRNVMARVLGQGGDGGQVFPNCLITLAVPTPAQRRSGCVDA HSLCQVVSVCNVVTVCNLTLNPQVLEDAGIEFLDPPKAQVSKEVRELKRQIERIFEEFE ERD" gene 8825..9997 /locus_tag="BP422_RS22605" /old_locus_tag="BP422_22020" CDS 8825..9997 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS22605" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="BP422_22020" /product="hypothetical protein" /protein_id="WP_088909602.1" /transl_table=11 /translation="MSFHLQQATLRANPAYKLVLYDRLPAEEQKALDELRHDPDFYGFL VPIEGTLAMKAVCRETALLFLTLQNPGSVPTYVQKLYGGAWEDDLFELILDDVIEVEVG GQFHSGAAAQALCGKSAPISKGHIGRLSMAALQYGEALGITKVPVLSRRLYDFNRLPAT SEWHRMIPDHSALLAYAGIQPDGPVQSKLQRHWIAVAHSRANGWLTWTNQNPATAIRPD SMIYKLYVSPHPSCLADALAAAIATFTECAVPNFKLGSDLYGILRPDKLIAYFSSLEEV MAVADKLKLRLTGCPAQGVPFTGELESSGLLSWGMDPPQVPSIAWSPMESWRLWITNHL ASALIAARLAPATGLSPWEFAMARIRLANVDPETWTPLPSLRWNLPDEEG" gene 10001..12361 /locus_tag="BP422_RS22610" /old_locus_tag="BP422_22025" CDS 10001..12361 /GO_process="GO:0031179 - peptide modification [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-iv: Pkinase" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-iv: LANC_like" /gene_functions="biosynthetic-additional (rule-based-clusters) APH" /gene_functions="regulatory (smcogs) SMCOG1030: serine/threonine protein kinase" /gene_kind="biosynthetic" /inference="COORDINATES: protein motif:HMM:NF017000.4" /locus_tag="BP422_RS22610" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22025" /product="lanthionine synthetase LanC family protein" /protein_id="WP_088909603.1" /sec_met_domain="Pkinase (E-value: 2.4e-20, bitscore: 71.4, seeds: 54, tool: rule-based-clusters)" /sec_met_domain="APH (E-value: 8.7e-07, bitscore: 27.5, seeds: 156, tool: rule-based-clusters)" /sec_met_domain="LANC_like (E-value: 6.9e-35, bitscore: 118.9, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MRITDVFVLPDDVQIKAVSELPADLLGDLVCEEGEQAIIRLGTRM PIRLLDEEGVKLLLHFRPAKTIGAAIIEYCRGNGGDPQSILEEAYPMLRLLIDSNLLVP ADSPAARPVTPSFRPRESVAGCRVVRCLQWLTDSELYHVKDSNGVNAALKIARPEFAEM MRPLFTHEAEVLRCLDGRVNPPLLAAGDLNGRPYLRIGWCPGEHVDTRAHNLRPLQTTL GRQRLLKLSCAVLDAYTHLHAQGVVHGDVHPRNILISDDGQVSIIDFGFSRREIHKDSG GMPNRGGIPYYYEPEYAWASLERRSPPHATQAGEQYALAALLYELITGKPYTNFSVEIE SMLQQITKEPPLPFADQGVAPWPEIEAILCRALSKSPPDRYGSLAEFSSHMRTLLHCEA VDHSPPAIPETAARIVFEVLDRVGPGGSLSFTDLTPPTCSVYYGAAGIAFALYRMACSR GDALLLSQADVWTCWAESAITGTDAFRIPEAQLPPEWFCTVTPFHQASGVYLIRGLVSQ ALGDPASMQRAIDSFVTACSTPCTNPDLTLGNAGVLLSCGMLLEAAPDIPGMDITNLLA LGNQLVESLWASSITVPNSYLGIAHGWAGILYATLHWHRITKNPLPEGTLKALEWLAAQ AKENGNRAWWPVTTDSEQAAQGWCHGSVGYVWLWTIAHHLFKQESYLQLAIQAAQYAWD TPAVNGTICCGMAGQAYAMLHLYRYTGEKHWLQKAFALTEGAADSIQRVDERRDSLFKG HLGVAVLAVDLEHPNRACFPLFEIEGWPGSQKV" misc_feature 12881..12895 /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: medium, score: 22.21" /tool="antismash" misc_feature complement(13111..13120) /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: strong, score: 18.57" /tool="antismash" gene 13363..14841 /locus_tag="BP422_RS22615" /old_locus_tag="BP422_22030" CDS 13363..14841 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018673171.1" /locus_tag="BP422_RS22615" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22030" /product="hypothetical protein" /protein_id="WP_236841173.1" /transl_table=11 /translation="MNQAHLLERYHQLRELAEDADAWLESEIGSDLWVDGINVFLTVSP EDFLEGLERFEGNYGFKNHGIVSTIRQFHHYCREASADGEFPLYQALAVGMTWLSLQPQ INGGYFNLPVQITNHSIALLLSPTYLAVWAHSYNEGIGLYLDLHSTLPTLFRPEHGRIY QNAGSYLEGTHIKFPFQNYFHEIAHILFFHDVYQRVLGSEDECRSYWTHIEACIYGLEE QVLAEMMEVQPDLHAIDDGFGGSKGFEDFISYRFRILGAQEDRSIPKDTVRTYIKRSMQ LGEANENIPDNKVKSRILASHKLDEERLEELDTHCKLFATALQVHSLWGIKSYQRNSIP AFREVVELLSPDAYCLQKLEESMRPDSWGTLEDLLSKNPFVEICSQTREKNIQVWNWRD TLSRLAEMRGYLANADEPGFVETNQELFQIANRLASVIHEEKQKEGPEEQYESQYADMN REISETINRLPNVEVRDHLHNLLSKPYYFVLEPN" misc_feature 14948..14959 /note="TFBS match to CcpA, Catabolite control protein A, confidence: medium, score: 18.11" /tool="antismash" gene 15086..15442 /locus_tag="BP422_RS22620" /old_locus_tag="BP422_22035" CDS 15086..15442 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016741884.1" /locus_tag="BP422_RS22620" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22035" /product="DUF6220 domain-containing protein" /protein_id="WP_236841174.1" /transl_table=11 /translation="MFIVLAWVFFAFIIVQVSLAGLGLFVNGEHWEMHRTLAQYFALLP VGMLVLSFLGKLPVHLRWICLGLYLMIVAQFLTVIYSSNLGILSALHPVIALFLFWGSL FTAKHAHNLGGKKA" gene 15439..16062 /locus_tag="BP422_RS22625" /old_locus_tag="BP422_22040" CDS 15439..16062 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015893442.1" /locus_tag="BP422_RS22625" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22040" /product="DUF2306 domain-containing protein" /protein_id="WP_088909606.1" /transl_table=11 /translation="MKLPKIWWGLFLVSLLVIVPFMFPYLTLDPANSRITIIPETVQYP LLVAHIVSAFIALLTGFFQFVDRIRLKKPSIHRFLGRVYVYSVFISGLLSLGSIFYAED FMKATSFFVLSLAWLFTCWKGYRTAINRQYEEHRKWMIRSFGMTLVAVSARLLVPVLLL LYFIFHGFSLPHGMETVIGEVLNVNIWAGLILNFVIVEWAILKK" gene complement(16346..16990) /locus_tag="BP422_RS22630" /old_locus_tag="BP422_22045" CDS complement(16346..16990) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015893443.1" /locus_tag="BP422_RS22630" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22045" /product="hypothetical protein" /protein_id="WP_088909607.1" /transl_table=11 /translation="MSSTLRNLLTMILLGAAGGITISFLDIEPTPMVWITFFMIAFVIL IGKDLYIFKLSTNMNTVERYVKHSKQPYYRFLYAYLHDNEVEAEKELAKITSDKLRAYI TIVVELHRSNYDLVEKALGKIDSIEHRHYYSAHLALLKNNQDAYNQHRSAIKNRIYQLL LDAEVAYHQGNMAEAEQCGQLAIAESKGVQKYLLIKTLEKSKRSQHRNSYF" misc_feature 17575..17591 /note="TFBS match to NuR, Nickel-responsive regulator, confidence: weak, score: 23.38" /tool="antismash" gene complement(17627..19612) /locus_tag="BP422_RS22635" /old_locus_tag="BP422_22050" CDS complement(17627..19612) /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF022063.4" /locus_tag="BP422_RS22635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22050" /product="Z1 domain-containing protein" /protein_id="WP_088909608.1" /transl_table=11 /translation="MTLDIGARTKRFLRLLTTEINSQEAQNILSNANSLVQAVGNVDEP SKQGLLFGQIQSGKTNNIMMSIALASDNGYRLFIVLTSDNTWLYDQTIRRIKSALPGLL TLGKEQWNAATYDSRIQDALEHTGLVLVATKNHNILANLEQFIAQTCASELKPIIYDDE ADQASLNTLINKDTNELSGVNQSIVNIRDYFPSQIYIQVTATPQALFLQCAESAFRPEF TVTFQPGRDYVGGQDFYERPQQLSPMRLFNDDEVESIITHTTENVDENWHAVPTGLRQA LCSFFVAASTKLLLGEGTAYSCMLHLSHLQEPHRRLETLIHGFITRLTRALLNPTSSDR DLVLQYLREAYDDMRITKTDCPGFGEVCQEIIDNIVSTHTQVLISERDNKIPSYDSPFN ILLGGNRLGRGVTIKGLLVTYYGRNSKNPQVDTLLQHCRMYGYRKKDMDVMRFYISRSL LDVFTSVYHSDQQLWNMAQQGSPTDMQAVVLSRTNNTILRATRRNVVYLDSLAFYTPGD RTFPLFPLSKNLSLLDQLLLPFDGKPQLVEVPLDILVQILNLTESEKQLVGWDDEAIRT CLRNMKQMDIYRNKGYLLVRSDRDITRGSRAMLSPNDYSQFNSDYPTLTMYRYNGKVEN GWEDGMPRWVPNLRFPDNRFFIISAF" gene complement(19612..20568) /locus_tag="BP422_RS22640" CDS complement(19612..20568) /EC_number="3.1.21.-" /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF044296.1" /locus_tag="BP422_RS22640" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="restriction endonuclease PLD domain-containing protein" /protein_id="WP_088909609.1" /transl_table=11 /translation="MPIYPRLYDDVINQNYALGLRRLEVLTGYASSSFVHHLIYTYENI HLDVILGMAKQDNISIWDHNEYVNLCENTGRLRVRYYNGRPAIHSKIFVWRGENGDAER VYTGSANLSWHGFRDYQEILVNANSDEIRAAFPPCDDLVDCTSPDVFQYFTMGFQQSPQ SSSIDAGAVNHIIGDRQFVTLPLVMVNQNREVHEKSGLNWGQRHGREPNQAYIPIPSAI HQQNPGFFPPRKHEFNLITDDGQSFVCVVAQDNNKALESSHDNSILGKYFRIRLGVPLG GKVQTTDLTQYGRDTVRIYKIDDETYYLDFSQRGYNS" gene complement(20753..21859) /locus_tag="BP422_RS22645" /old_locus_tag="BP422_22060" CDS complement(20753..21859) /GO_function="GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015256370.1" /locus_tag="BP422_RS22645" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_22060" /product="DNA cytosine methyltransferase" /protein_id="WP_088909610.1" /transl_table=11 /translation="MIFRKGELFNGPGGFAWGAKNARVEANGMTYAVEHTWSNDYCDSA CDTYTHNICPDKPESVHRGDVRLLNLEELGEIDAFIYGFPCNDFSIVGEKKGFDGTYGP LYSYGIRVLKHYQPKWFIAENVGGLQSANEGKAFLQILSEMNEAGYKLTPHLYNFADYG VPQTRQRILIIGFRKDLNMEFRVPAPTHGPNRPHPYKTAYDAIMEPPILENAYNNDMPK HKPKVIEFLKAIPAGQNAWYDGIPEDLRLNVKGAKMSQIYRRLEKNTPSYTVTGSGGGG THMYHWEEPRALTNRERARLQTFPDEFYFHGTKEKVRQQVGMAVPPEGARIIIEAVLKT YAGVEYDSIKPKWDVEQMLEQKIDSLFL" misc_feature 21937..21950 /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: strong, score: 23.1" /tool="antismash" ORIGIN 1 ttcaggatta tgcccaagtc attgaagcaa accttcaaga ggcagtagaa gatgtatcca 61 ttgataaaca gattcgtact gtagtcgaca accaggtggc catccaattc aatgcaaaag 121 gcaaggtaga cggtattaag gtcgcttata ttgtgacatt agtcgaaacg cctacacatt 181 ttcatcaaat catggcttgg acagaagaaa agaggtttgc gcccctcaag caagaactgc 241 aaaaggtcag tgcaagtttt cgcgaggtaa aatagcgaca gaacacagaa gccgcctaca 301 tcgggtggct ttttttctta gaaaagcagg actctactcc tagttgcaga caggacaata 361 taacgattga aaaatgtggt ttaaatgtat aattgaaggg tggtcctcct ttacatataa 421 tgttaaagta atacaagtag tcaatttttt ctagaaaatc tattccgata agtgctaatt 481 ttcgggtcag ggtagcgctc ttaatcctta agagttacta taaatatttc ttgagaggtg 541 catgtacatg tttatgggga aaggaacagt ccgcgagctc ggaaatcaaa tcgacaaggt 601 tcttggagat attaaagata tccaggcaga aatcgaccgc gactctgata aaattgacaa 661 cgaattgaat tcatgctctc gtgagctgat caatgcacaa acaacgctgg gtgaaattca 721 gccactgatc gaaagtctcg ttgctcaggt tggtcaaaat gcccctgatc acattaaagt 781 gcttgttggt accattgcag atggtattac gggtaaagtg aaaaatacgt taaacaacct 841 ggcagaggtt caaaagaacg tgaaggacgt tgacaagctg acagacgcca tcgacggaca 901 tacggataaa attgcacaaa aagttaaaga aatcgatagc atcactgaca aagttcaaaa 961 gtaggtgatc gaatgtcgta tataaacaat tcgaacggtt ggggtactca gcatacgaat 1021 catgtggcaa ataaggttga ccacctcgct gacaaaattt cctttgcagt ggatatggta 1081 gccaatgcag cgattaacct ggacggcgct caacaagagc tgcttacact ggcaaatgcg 1141 ccctacccac cacaatctac ccaattaatt acgttagcga atcgcattgc agcgaataag 1201 cgccaaattg atgatggctt ggctaaaatc aaagaaatgg cccgcactat cgatcaagaa 1261 acgaatcaga tccagacccc tcctcaaaaa ggctggtaaa gaaaagagga gctcttctta 1321 gggctcctct tcgcatttct ccgttttcat tcctctcgtg ctacttctcc atcgactctt 1381 tatcactggt atttttgtag gatttttgat tcccccatgg aggttctgct ctcatcaagt 1441 gccgtacaaa ataatcccat tttctacgga taaagtacgg ttccaaagaa aatccgtgat 1501 gtcggttggg caaaatcaac atgtcaaaat ctttatccgc tttaatcaat gcattcgcca 1561 tccgaatcgt ttgggaagga tgcacatttc catccaaatc gccactgacc aacaagagct 1621 ttccttctag attcgctgcc agacgagcat tgtcttgatc cctgtataag tcagggtcgt 1681 acaaaccttg atagcgttct gcccatgctg ctatatacag tcgttgatca tgattaccac 1741 acgcggaaac cgccgtcttg taaaactcag gaaatgagag tatggccctt gtcgaagcgt 1801 agcctccccc tgacgatccc caaatgccta cccgatcaac atccacatac gggtagcgct 1861 ctgccaattg ctttatcgct atcacatggt caagcaaacc tcctgcttcc tccaaatttc 1921 cgtttgaaat gtcatggaac gctttagaac gataaggtgt tcccattcca tctaggatca 1981 atacgataaa ccccaactgc gccaatgact gtccaccacc cagcgggtca tggcttcggc 2041 cgggatcaag cgcgaaagct ttcggtgtat tgatgatctg tggtcccccg taaatgtaat 2101 ctacgaccgg atacttgcgg gaaggatcaa acgggaatgg gcgcagcatc accccataaa 2161 gatcggtcac accgtctcgt gctttgacgg taatcctttc tggaaattgg taccccatct 2221 cgagcagcat ttccacatca gcgtactcca attcgcgaat caggctgcca tctaccgagc 2281 ggagaacagt aacaggaggc aaatcaactc gcgaaaacgt atcgacgaaa tacttcagat 2341 taggagaaaa cacaacatca tgctctgcat cttctggcgt caacaacgac aaaccggttc 2401 catccaggcg aacgcgatac aggtgttgat aataaggatc gcgcccttcc tcaagccccc 2461 ctccagtgat atacacccat ccctgctgct cgtccactgc catcagccta cgtaccgtcc 2521 aggaacccga tgtgatcgga ttgcgaatct cccccgtttt gccatcgcaa tagtagaggt 2581 ggctccatcc atcacgctct gaatgccaga tgaacgaacc atcggccaat aatcgaaaat 2641 tcggattgga cgctccgaga ttatgcaggt cttggtttaa aaacgtatcg ctttgttccc 2701 gcagtagcgt gcaaacctca ccggagcaag gatccgctag ggaaaaatct acagaacggg 2761 catcacggga catccgggcg atatagatct gtttactgtc ggatgaccat ccggccattt 2821 gcatcccctg agtgaggggt gagactggac atgccattaa aggctcgctt tcaatccgga 2881 ctgtggttcg cctttccaga ttacagatga ccagctctgc caatggtacg tgttgatccc 2941 caacgagtgg ataacggtat gagtgcagta ccggtctaac tccttcccct ttcggaacag 3001 attggatcag atccatttcg cgcacctttc tttggtcaag cctatgggtc agcagcatct 3061 tggaatcggg tgaccaaata gctactggag gaagcttagt cccattcaat cgctccgcca 3121 tgatcgagag cctacattca ggttgggttc cgtaatcata gtaagccttg ccgtcatagg 3181 taagcctgat acgccttccg gtttcgagtg atcgaacata caagttgtga tcatatacga 3241 acgccaccca ttttccatct ggagacggca gttcatccat cgacggcttt ttaaaatttt 3301 ttaagggctt gcaggtgtat tcctgcaaat cacagctcca aacagtaccg cccacctcaa 3361 actggaatgc cgatccactc tcggtaaaca taagttcccc aagtggcaat gtttctgcat 3421 catacccttt gcctgcacta cctgacaaac agacagctaa tcgttcgtga tcgaatgctg 3481 gctgactcgt attctgttca gcgtccacga tcacatattg cctcccacta cccttttcca 3541 gacgtatttc acggatgtac cagaactgac tcccgctaat ccaccgcggc ctgacaaaag 3601 cattgaatac tgcgtcgtaa taattggcgg gatgcaagcg ttgtgccctc tcatactgtt 3661 cccatgtgac aacattctcc atgtcaatcc ccctctttca aagtgagata caagaatcat 3721 gtgcttcaca tttttgaaaa acaaaatccc ttatttatcc aattattaca tgcatatgta 3781 aaaagcggga taatatatct acgaatttac ttttttagca cctgacacgt gaattttttt 3841 caagaagaaa gaggcgatct ctcgcctctt cgctcttaac atagattact ccgcttccgc 3901 tatcatggtt tggttcctac ccgatctctt cgccttgtac atggcctcgt cagctaattg 3961 cagcaggcct tcaggagaaa cagcatgaga aggatagtgc gcaatgcctt gtgacacagt 4021 tatcgactgc ccgattgggt ttgtacgtgt ttctaaagca tgacgtattc gttcggccac 4081 ctgatatgcc tcctccaaac cagcatgaga aacgaggaca acaaattcct caccgccaaa 4141 gcgacagctg acatcatcag gccgaagtaa ggaagaaatg attttcgcaa aatgcctcaa 4201 cacttcatct ccagccggat ggccatatgt gtcattaata gctttaaatc gatcaaggtc 4261 catcataata gtagaaaagg ggatttgctc cgccatccat tcttgcatgg tttcctcaag 4321 cgttcttcgg ttcgttagcc ctgtcaaagg gtctgttcgt gcatcatgag ccaattgctc 4381 cgtctgcttt ttgatattgg ttaaggcaaa gcgaatggca tgagataaca gctcggcctc 4441 ccgattccaa tgctgaccac cctcagagag ttccacctct tctctcccgg ccttactcac 4501 aagattggcc aaagatacga aaggtttcgc tactttgcgc gcaagcccga tcacaactag 4561 cattaataat aaaaagggag gcagcatata caacaaaatg gattgaatat cacgatttaa 4621 ttgttcttgc acaacactga taggtgacac gacaacaaca ccccagtcat tcgctggaac 4681 ctttacgtac gcggctaata ccgtctgtcc cctcaagttg acgatctgtt catagccact 4741 tttcccctgg atcagcttgc gtacggctgg attggcactg atatcctctc caatccggtt 4801 tgtatcacgg tggaacaaca aatgaccatc agatcctacg atgtaaaaag aggaacctag 4861 ttcgtctgtt ggattacttc caaagatcgt attcaaaatg ttatcttcat gaagataaat 4921 cgttcccccg ataatccccc gatagaaccc gtccttatca aatatgggtt cgctcatcaa 4981 tacaatgagt cgcttcgtgc ttgctgttac gtaaggctcg gaaatgtatg gcttttttaa 5041 tgccaatgcc gttttccccg ttttcgtttt aacatagctt cctactgtac caatagatcc 5101 gggagacaca cctcgaacaa gcccggtctc atctaccacg gaaaccgaat taaaatagtt 5161 gtttgtacga cggatcaact caagcttgga atatacctca tccgcattca tttctttccg 5221 attggaaaag atgctcgccg aatactgtaa gctactgcgc atggatttaa tcaaagcgtc 5281 tagagtatga ctcattttga ttgcactcgt gtgatttaag gtcaaagtcg tgttaatcag 5341 tgcctgtttt ttggattgat agaatgagag gagtaggatg gtgacagtca agacaacgga 5401 taaagagact agtcctgtta aaagtgtcac taggctaatc tttttcgggt ggtttgctct 5461 tttttgtaag acaggcattg gatgccccct tgtatttagc atgctagcta ttaagcaata 5521 aataaaaaat agtctaacac tccataatat tcatttcaag tatacaagga agttcaagca 5581 tccgaccttg gctttgtgac ataaaaaagc cacctttgtc aggtggtagt ttcggcaatc 5641 atcatctagg agacccgaaa gctttgtctt ctcatccaca tcgtggcaac ccacttttct 5701 ccatggatca cttgtgtccc tgcatgcaaa gtgagctcgt ttaattcttg atttctataa 5761 aaatattcaa agtagacagc catgcctttg gtagggaaaa cagataaatg aagcaaaggg 5821 aacaccgttt caccgccttg ctccacatca ttcaaataca tcacgagcgt actaatgcga 5881 ttgttcgtac ttgctcgact cgtttctgca aagaaatcat aatgaggttt atattcttga 5941 ccaggggtat atcgtagaac ttgcaagcca tcaccatgct caatcggaat gttcatgatt 6001 tgagagattc gcttctcgat ccttgtaatc gtctccatct gctcgcagaa catcccgctg 6061 ctcgttcgaa tagagtggac tgaacgatct tcgcctattt ttgagcgttg caatcgttct 6121 ctggaatgtt cgattagctc ttcgcattcg ctatcgctaa gcacatttcc taacacgaca 6181 accagcggtt cctcatactt ggcaagaatt tgaatctctc gatcttctgt cttgatccta 6241 tttccagtat gatcaaatat tgtccgttct ttctctgtcg tgtgccctat catcgttatg 6301 caccccatat atatgacatc cgtcgcaaaa aatagaatac cataaaatgg gtaacttcaa 6361 tcagtaaact ttagaaaaat tagaatattt ttaactgtta cttgaggtct ttggcttaag 6421 aacaaaaccc gtctcctata tatcaaggga cgggtttgta aagcatcttc taagtggcat 6481 gtgtctatat gaaaagttat tttcatgcct ccttttgttt ttgaacgtgg tacatattct 6541 tccggaatac actgatcatg tatccgcata tcccacctat tagagaaggc agcagccagc 6601 ccaaacctac gtcatacagt gggaggtact gagtaaaata atgatggaca acactgtttt 6661 caactccagc agcctttaat ccatcaaaca gactaatcag aaaagtgaaa agtaaacttc 6721 cttgatacac ttctggtctg ccgttgaagg ctttgtgcag aaacgtcaag aagagtaacg 6781 agatcgcaat cgggtacatg gtcattaaga tcggaacaga gaccttaatg agctgcgtta 6841 atccaatatt agcaacgagt gtactgaaaa cagacaaaat aaccgcaaat tttttgtaag 6901 agatcttcgg aaacaatgaa tgaaaaaagg aagagcaggc tgtaataagc cctacacttg 6961 tagtcaaaca tgccactgta atcattaatc ccaataaaat ggcaccatac gaaccaaagt 7021 agtaattcga aactttcgcc aaaacctcag cgccattttc taagtggccc aacttttcta 7081 cactagaagc acccataaag gaaagggccg tatagaaaag tgcgaggagt aaacccgcta 7141 tcattgttgc ttttgcgcac gtagccaaaa cttgttttct ggcagtaact cctttttctt 7201 taatcgcatt cacgatgatc attccaaaaa caaaagcgac aagcgcatcc aatgttaaat 7261 acccttcttg aaaacccttg aaaaatacat gggatgtata atctgcttgc ggagcttgaa 7321 gggctccgat tggataaaca atcgctgtta ctgcgataat tccgataaaa gttaatttaa 7381 taggagttaa gatttttccg actacatgga taattttcat aggattgagc gataagaagc 7441 aggcaattgc gaaaaacagg atggtaaata gaatcagcgg tgccgaacct gcctgttctg 7501 ataggaaagg ctttacccca atatcaaacg atacattgcc ggatctaggt atcgcaaaaa 7561 acggaccgat tgctagatag agaacaatcg tgaataccat tccgaatacg ggatgcacgc 7621 gactggctaa ggagcgcaag tcgtcttttc ccgaataaac aaaggctgtg attgctagca 7681 aaggcaaccc aacccccgta accaaaaaac ctgcattggc tatccataca tttgttcctg 7741 ctaattggcc aagcattggc gggaaaatta aattacccgc tccaaaaaac agagcaaata 7801 acatgaatcc tatcgtaact acaaaagaaa ctggcgcttt ctgtgacaca acaaacctcc 7861 taattattct atatctctca ttcataaatg ttcatgctta ccaatcctaa atttattcat 7921 tctgatacta tactctaaat aaacattctg ttcaaacaca tataactcag agtacgcccg 7981 caagagaaag aattatcttt ctcttccaaa tatggagtgg gctaggtact ccatggttgc 8041 cggaaatcaa gcttacatcc ctgatacagt atactacaag catccttagt gtcgcatctg 8101 gaagtacctt ccgatgttaa cttacatatt tcggtgtgga tctgcctggg tgaaaaataa 8161 taaagggaac aaatctagtt acgatcgttc ccccaaaacc tcttcattct tcctttcatt 8221 ccgttttatt tgaaactcct tgtaaatgca tgaggtaccc tagtttgaat ggggattact 8281 attttaggct ctagcagatt tcttttgaac tctgtaacca tgtcccttta gcacgaatag 8341 aatgtacaag ggttcgaggc cattgcgcct gcattaggaa cctaaagggg gggattttta 8401 aatggccttc aaatctcgta atgtcatggc gcgtgtgtta ggtcagggcg gcgatggtgg 8461 tcaagttttc ccaaactgtc tgatcacact tgcggtacct acgcctgctc agaggagatc 8521 cggctgtgtc gatgcccaca gtctttgtca agtagttagc gtctgtaacg tcgtcaccgt 8581 ctgtaatctc acccttaacc cacaggtgct cgaggacgct ggtattgaat tccttgatcc 8641 acccaaagct caagtgagta aagaggtgcg tgaactgaag cgacaaatcg agcgcatctt 8701 tgaggaattt gaggaaagag actaataatc gtggtcagtt ccctgcttaa ccggtagggg 8761 ctgccctaca taccggagcg cattcgggcg ccgtactcat actcataatg gaggggaacc 8821 ggacatgtca tttcatttgc aacaggccac gttgcgggcc aaccccgctt acaaactggt 8881 cctctatgat cggctgcctg ccgaagaaca gaaagcgttg gatgagctgc ggcatgatcc 8941 tgacttctat gggtttcttg tgcccattga gggaacattg gccatgaaag cagtgtgccg 9001 ggagacggcc ctcttgttcc tgacgcttca aaatcccggt tccgtaccga cctatgtcca 9061 gaagttatat ggaggcgcat gggaagatga tctcttcgag ctgatcctag acgatgtaat 9121 agaggtggag gttggaggcc aatttcattc aggggctgcc gctcaggcgc tttgcggtaa 9181 atccgcgccc ataagcaagg ggcatattgg acgtctgtca atggcggctc tccagtacgg 9241 tgaagccttg ggtatcacaa aggttcctgt cctctcccgg cgattgtatg acttcaaccg 9301 tcttccagcc acatccgaat ggcaccgcat gataccagac cattcggcgt tgctggccta 9361 tgcaggcatc caacccgacg gaccggttca atcgaaacta caacgccact ggatagccgt 9421 ggcgcattca cgcgccaatg ggtggctgac atggacgaac cagaacccag ccacggccat 9481 acggcccgac agcatgatct acaagctata cgtaagcccc cacccatcct gcttggcgga 9541 tgcattagca gcggccattg cgacctttac tgagtgtgcg gtgcccaact ttaagctcgg 9601 cagcgatctg tacggaatct tgcggcccga taagctcatt gcgtatttct ccagtctgga 9661 agaagtgatg gcggtggctg acaaactgaa actgcggttg acagggtgcc cggctcaggg 9721 tgtgcccttt acgggagaac tggagagcag tggacttctt tcatggggaa tggatccccc 9781 gcaagtgccg tccatcgcgt ggtcgccgat ggaaagttgg cgactatgga tcacgaacca 9841 tctcgcatcc gccctgatcg cagcccgact ggcacctgca accgggctct ccccttggga 9901 gtttgctatg gccagaatcc gcttggctaa cgtggacccg gagacctgga ccccattacc 9961 atcgctgagg tggaatctac cagacgagga gggatagcag atgcgcatca cagacgtttt 10021 cgtattaccc gatgacgtgc aaataaaggc agtatctgag ttacccgcgg atctcttggg 10081 ggatctggtt tgtgaagaag gcgagcaggc aatcattcgg ttaggaacgc ggatgcccat 10141 ccgcctgctc gatgaagagg gagtgaaact tctgctccat tttcgcccgg cgaagactat 10201 tggagcggcc attattgaat actgccgtgg aaacggaggc gatccccagt ccatcctgga 10261 agaagcttac ccaatgctgc ggctcctgat cgatagcaat ctgcttgtgc cagccgactc 10321 ccccgccgcc cggccagtta ctcccagttt tcgtccaagg gagagcgttg caggctgtag 10381 agtggttcgc tgccttcaat ggctaaccga cagcgaacta taccacgtta aagatagtaa 10441 cggagtaaac gcagcattaa agattgcccg acctgaattt gccgaaatga tgaggccctt 10501 atttacccat gaggcggagg ttctaaggtg tctagacggt cgtgtaaacc cgccattact 10561 cgcggccggg gacctgaacg gtcgtcctta tctccgcatc ggctggtgtc ctggtgaaca 10621 cgtggacaca agagcgcaca acctccgccc cctgcaaacc accctcggcc gacagcgttt 10681 gctgaagctt agctgtgcgg tgcttgatgc ctacacgcat ctgcatgcgc aaggcgtagt 10741 gcatggtgat gtccatcccc gcaatatcct tattagtgat gatggacagg tttctatcat 10801 cgactttggc ttctcccggc gagagatcca taaagattct ggcgggatgc caaatcgtgg 10861 aggcattccc tactattatg aaccggagta cgcttgggcc agcctcgagc ggcgttctcc 10921 tccccatgca acacaagccg gagagcagta tgcactagcg gcactgctgt atgaactgat 10981 cacaggtaag ccctacacca atttctcggt cgaaatagag agcatgctgc aacagatcac 11041 aaaagagcct cccctgccct ttgcggacca gggggttgcc ccatggcctg agatcgaagc 11101 aattctttgt cgggcactta gcaaatctcc accggaccgg tatgggtcct tggccgagtt 11161 ttccagccat atgcggacac tcttgcactg tgaggcagtc gaccactcgc cgccagcaat 11221 cccggaaacg gcagcccgca tcgtttttga agtgctggat cgagtgggcc caggtggatc 11281 cctttccttc actgacttga ctccacctac ctgctctgtt tactatggcg cagcgggtat 11341 tgccttcgca ctctatcgca tggcttgttc ccgaggagat gcgctgctgc tgagtcaggc 11401 cgatgtctgg acgtgttggg ccgagagtgc gatcactggc accgatgcct tccgcatccc 11461 tgaagcccaa ctaccgcccg agtggttctg tacggtcact ccgtttcacc aggcttcagg 11521 ggtttaccta atccgagggc tggtcagcca agctttgggc gatccggcaa gcatgcagag 11581 ggcgatagac tccttcgtaa cggcttgcag tacgccatgc accaatccgg acctgactct 11641 tggcaacgcc ggtgtgctgc tgagctgtgg catgttgctg gaagctgcac cggacatccc 11701 gggcatggat atcacgaatt tgttggcgct gggtaatcag ctggtggaat ccttgtgggc 11761 ctccagtatc actgtgccaa atagttacct gggtatcgcc cacgggtggg ccggcattct 11821 ttacgctact cttcattggc acaggatcac taagaatccc cttcccgaag gcactttgaa 11881 ggccttggaa tggcttgcgg cacaggccaa agaaaatgga aacagggctt ggtggccggt 11941 tacgactgac agtgaacaag cggcacaggg atggtgtcat ggcagtgttg gctacgtatg 12001 gctttggacc attgcgcatc atttgtttaa gcaagaatca tacttgcaat tggcgataca 12061 ggcagcccaa tatgcgtggg acactccggc tgtaaacggt acgatctgct gtgggatggc 12121 tggtcaggcg tacgcaatgc tccacttata tcgctacacg ggtgagaaac attggttaca 12181 gaaggcattc gccctcaccg agggggccgc ggacagcatt cagcgggtcg atgagagacg 12241 tgatagtctt tttaagggtc atttgggtgt tgccgtatta gcagtggact tggaacatcc 12301 gaaccgtgct tgttttcctc tgttcgaaat tgagggttgg ccaggatcgc agaaggtata 12361 gacgatttta ggtcatgtcg gcaagaggcg ttgctaggcc tctctcattc tccagtagca 12421 gcagcgtgga accgaagcaa ctgtgagcat gacgcagaac ctcctgcagg tgtggagcct 12481 cctagctgaa atggcggcgg acccgtcgta cagatattac aaagctgggc tcgtcacctc 12541 gttttcgata gtctttaatc tttttaaccg caacaagcta tttaatggga aagtcgtaac 12601 ctatctgcgt tcgtcatcta aacagcaatc tgaatgcgag ctatccatca ctgcacaccg 12661 cgaagccata ctcgtccaca aattcaagtg ttttaactga agtcttgagg atcgtatcat 12721 ttacaaagcc ctgctcaata agcagggtat tttttgtact ctgttgttga tcactctgct 12781 agacagtaat tcgtaaatca ttgtgctaac cgactcgaat agaacacgag gttcctcgcc 12841 ttggtacttt tttatacgta atgctttgtg aaatgtttat atatttcaga aaatatttat 12901 ttttcttaac ttgaaatcaa ttgacaattt tccttataat tacaattaag gtttttgttg 12961 ataaaaaatt atatatagtt ccatccaatt ggaaaggagg tgtaaactca tgaaaaaagt 13021 cgtaaaagta gaagtaaaca agaacaaaca agtgcaagaa atgaaagcgt tgaaatggcg 13081 cgtagttgtt gatgtttgct tgtaagagag tcaaaaaaca tgcatgattt ccgtaaaatg 13141 ataaaagtta ggaaggacgg gattgcccat gaaaaaggta gtgaaagcac aactttctaa 13201 caatcaaaac gttcaagaaa tgaaattgct tctccatcca attttaacac ttgtgtgtaa 13261 aatgtaattg attgttcaag agcacctcgt gtgctcttga attttttgca taaagttctc 13321 gctttcgagg cagtaagcaa acatgacagg atggtgcagt ttatgaatca agcgcatttg 13381 ttggaaagat atcatcagtt gagagagctt gccgaggacg cagacgcatg gctagaatct 13441 gagatcggtt ccgatctttg ggtggatgga attaacgtat ttttaacagt atcaccagag 13501 gattttcttg agggacttga gcgattcgaa ggtaactacg gttttaagaa ccatggaatt 13561 gtaagcacta tacgtcaatt tcatcattat tgtagagaag catcagcgga tggtgaattc 13621 ccattatacc aggctctagc agttgggatg acctggttaa gcttacagcc tcaaataaac 13681 ggcggctatt tcaacttgcc tgttcaaatt accaatcact ccatcgcttt gttgttaagc 13741 ccaacctatt tagctgtttg ggcacatagt tacaatgagg ggattggatt atacttagat 13801 ttacactcga cactacccac gttattccga ccagagcatg gacggatcta tcaaaatgca 13861 gggtcgtatt tggagggaac tcacatcaag tttccttttc aaaattactt ccatgaaatt 13921 gctcatatcc tattcttcca tgacgtctat caacgtgtgc ttgggagcga agacgaatgt 13981 agaagctact ggacacatat cgaggcatgc atttacggac ttgaggagca ggtgctcgct 14041 gaaatgatgg aagtccaacc agatttgcat gccatcgatg atggatttgg aggtagtaaa 14101 ggattcgagg attttatctc ttatcgcttt aggattcttg gtgctcaaga ggatagatcg 14161 ataccaaaag acacggttcg cacttacatc aaaagaagca tgcaattagg cgaagcgaat 14221 gaaaacatcc ctgataataa ggtaaaatcg agaatccttg ctagccataa gctagatgag 14281 gaacgattag aagagcttga tactcactgc aagttatttg ctacggcatt gcaggtacat 14341 agcttgtggg gaatcaaaag ctatcaacga aactcgattc cagcgtttcg tgaagtggta 14401 gagttactct cccctgatgc gtactgtctg caaaaactcg aagaatctat gcgaccagat 14461 tcatggggta cattagagga tttgttatcg aaaaatccgt ttgttgagat atgctctcaa 14521 acaagagaaa aaaatattca agtatggaac tggcgtgata ccctgtctcg gttggcagaa 14581 atgcgcggat atttggcaaa cgctgatgaa cctggtttcg ttgagaccaa tcaagagcta 14641 tttcagatag caaatcgttt agctagcgta attcacgagg agaaacaaaa agagggcccg 14701 gaagagcagt atgagagcca gtacgccgac atgaaccgag aaattagcga aacaataaac 14761 cgattgccaa acgtggaagt acgcgatcat ttgcacaatc ttctctccaa accctattac 14821 tttgtgttag agcccaatta ataactgatt atgagtcaaa gaccggcgat acttcctatg 14881 ttggtctttg ttttttatgc aatttataca taagccgatt tgacattcag attttatcct 14941 ttttttagaa aacgtttagg gtttgttttg aacttgcgtt taggatgggg gtaagacaaa 15001 tgattcagat gggagcggtt tttgcatgct tgagataaat gagaagattc cccttccccc 15061 tcctcgtgtg aaaatatgga ggtacatgtt tattgtcctc gcatgggtgt tttttgcttt 15121 cattattgtt caggtatcac tggcaggtct tgggctgttc gtcaacggag aacattggga 15181 aatgcataga accttggctc aatattttgc attgcttcca gtcggcatgc tggttctctc 15241 tttccttgga aagctgcccg tacatcttcg ttggatttgt ctcggattat acctcatgat 15301 cgttgcgcag ttccttaccg ttatttattc ctctaactta ggaatcctct ctgcgcttca 15361 cccggtcatt gccttgtttc tcttctgggg atctctcttc accgcaaaac atgcacataa 15421 tttagggggg aagaaggcat gaaactcccc aaaatttggt gggggttatt tcttgtatct 15481 ctactggtca tcgttccatt tatgtttccc tatttaacat tagaccctgc aaacagtcga 15541 ataacgatta ttcctgagac tgttcagtat cctttattag ttgctcatat cgtttctgct 15601 ttcattgctc ttctcactgg ctttttccag tttgtcgacc gaattcgcct gaagaaacca 15661 agcatacatc gttttcttgg gagagtttat gtgtacagtg tgtttatcag cggactcctc 15721 tctttaggga gtatctttta tgcagaagat ttcatgaagg caacaagctt ctttgtctta 15781 tctttggctt ggctgtttac ttgctggaaa gggtatcgta ccgcaatcaa caggcaatat 15841 gaggaacacc gaaaatggat gattcgcagt tttggaatga cactagttgc cgtaagcgcg 15901 cgtcttttgg tgccagtatt actccttctg tactttattt ttcacggttt ttctcttccg 15961 catggtatgg aaaccgtcat tggagaggta ttaaatgtaa atatttgggc tgggcttatt 16021 cttaattttg ttattgtcga gtgggctata ttgaagaaat aggcttcgtc acgccacgtg 16081 ggcgatggaa tggtagcgca aagaaggact gtctcgatcg ttgaatcggg acagtccttc 16141 ttgtcgaaga aaaacgcaga tctagatatg ttttaccggc acacaaaaat caacgatgtg 16201 cctctctcct acttgctcac ctgtataata ttcgtagcat tgacgatcat ctggtacgta 16261 tccactctgt ggtagccatg tgacgacgcg gttgattcgt gagacacggg cctcccggaa 16321 tcagaaaacg aactaggaaa gtgacctaga agtaagagtt ccgatgctga ctgcgtttgc 16381 ttttttcaag tgtcttgatc agcaaatatt tttgtacgcc cttggattcg gcaatggcta 16441 gttgaccgca ttgttctgct tctgccatgt ttccttggtg ataggccact tcagcatcga 16501 gtaacaactg gtagatacgg tttttgatcg cggagcggtg ttggttgtag gcatcttggt 16561 tgttttttag tagtgctaaa tgtgcggagt aataatgtcg atgctcgatt gaatcaatct 16621 tgccgagtgc tttttctacc agatcgtagt tgctgcgatg gagttctacc actatcgtga 16681 tgtaggcgcg gagtttatcg gatgtaattt tggctagttc tttctcggct tccacctcgt 16741 tgtcgtgtag ataggcgtat aagaaacgat agtaaggttg ttttgaatgt ttgacgtagc 16801 gttcaactgt gttcatgttg gtgctgagtt taaaaatgta caggtctttg ccgatgagaa 16861 tgacgaaagc gatcatgaaa aaagtgatcc ataccatagg cgtaggttct atgtctagga 16921 aggagatcgt tatgccacct gcggctccga ggaggatcat ggttagtagg ttacgtaggg 16981 tggaagacat gatggtgctc ctttgcttgg aagtattcct ttagtttagc ataagggaaa 17041 gactcttcat ccaaaaattg gggaaagggt cgtttgtagg ttttgggacg ctcctcaaaa 17101 ctgcccaaag tttctcacat cagtgcgccc agcgactcga atagcattag gtttagtcca 17161 gtatacatgg gctgaatctc taaaacgctt gttatattgt tcttcccaaa ccgcaatgta 17221 tagaatatag ttattatcca ctttaattct tttttaattt ttctcctgta atggtcaata 17281 tctttagtgt ttgaaagtta gttatccatt gttaagttgc ttctcttcct cgatttagta 17341 atcaattgta ctgctacgtt tattcgtttc ctgcctcttg agcacggtct aactatcgac 17401 taggtatcat aggaataata tatattaaaa acacgagact actaaaaaag tcgtgtcctt 17461 tttatcaagg acacgacttt ttttacaatc tactttgggt aaatcctaag tataaataac 17521 tgatattttg gatatttgct aaaagatgct cgtatcccct aacgagtggg gcatttgaac 17581 aagactagca agttccatat gcttttatta gctaactagt taagatttag aatgccgata 17641 ttatgaaaaa tcgattatcg gggaatctaa gatttggtac ccatcgaggc attccatctt 17701 cccatccatt ttcaactttt ccgttatacc tatacatagt aagggttggg taatcggaat 17761 taaactgact ataatcattc ggagagagca ttgctcgact ccccctagta atgtcacgat 17821 cacttcttac cagtaaatat cctttgtttc gatagatatc catttgcttc atatttctta 17881 agcaagtacg gatggcttca tcatcccagc caacaagctg tttttcagat tccgttaaat 17941 taagtatttg cactagtata tctagtggaa cttcaacaag ctgcggcttt ccatcaaaag 18001 ggagcagaag ctgatccaag agtgataggt ttttagatag cggaaataaa gggaaagttc 18061 gatcgccagg cgtataaaaa gccagagaat ctaagtagac aacatttcgt ctagttgctc 18121 ttaatattgt gttattcgtt ctggaaagaa ccacggcctg catatccgtt ggtgagccct 18181 gctgtgccat attccataac tgttggtcgg agtggtaaac actagtaaac acatccagca 18241 aagatcgaga tatgtaaaaa cgcattacgt ccatatcttt ttttcgataa ccatacatac 18301 gacaatgttg aagcaaagtg tccacctgtg gatttttgct gttccgcccg taatatgtta 18361 ccagcagacc tttaatcgtt acacctctcc ctaaccgatt cccccctagt aggatgttaa 18421 atggagaatc ataactaggt attttattgt ctctctcaga aattaacacc tgggtatgtg 18481 tacttacaat attatcaata atttcctgac aaacttcacc aaaacccgga caatcggttt 18541 tcgttatcct catatcatcg taagcttctc tgagatattg taagacgaga tcgcgatcag 18601 atgatgtcgg attcaataag gcacgagtaa gtcttgtaat aaatccgtgg attaatgttt 18661 ccagtctcct atgtggctct tgaagatgac ttagatgcaa catgcaggaa tatgcagttc 18721 cttcacccaa caggagtttc gtagatgctg ctacaaagaa agaacacagt gcttgcctga 18781 gaccagtagg tacagcatgc cagttttcat cgacgttttc ggtcgtatgg gtaatgatgc 18841 tttctacctc gtcatcgtta aacagtctca ttggacttaa ttgctgagga cgttcataaa 18901 aatcctgtcc tcctacgtaa tctctgcctg gctgaaaggt taccgtgaat tctggacgaa 18961 aggcactttc tgcgcattgt aaaaataatg cttgtggggt agctgtcacc tgtatataaa 19021 tttgggaagg gaaataatcc ctgatattta caatgctttg gttaactccg cttaactcgt 19081 tcgtatcctt atttataagt gtattcaaac tagcttgatc agcctcatcg tcgtagataa 19141 tcggcttcaa ttcagatgca catgtctgag ctataaactg ctctaaattt gccaaaatgt 19201 tatggttttt tgtagcaacc agaacaagcc cggtatgctc caatgcgtcc tgaattcggg 19261 aatcatatgt ggctgcgttc cattgctcct ttccaagtgt gagaagtcct ggtaaagctg 19321 atttaattct tcttattgtc tgatcataga gccaagtgtt atcagatgta agtactataa 19381 atagtctgta accgttatcg gaagccaatg caattgacat cataatgtta tttgttttac 19441 cactttgaat ttgcccaaat agcaatcctt gcttgctcgg ttcatcgaca tttccgacag 19501 cttgaaccaa actgtttgca ttactcaata tattttgagc ttcttgtgaa tttatctccg 19561 tggtgagaag ccttagaaac ctcttagtac gtgcccctat atccaatgtc attacgaatt 19621 ataccccctt tgactaaagt caagataata agtctcgtca tcgattttgt atatgcgaac 19681 ggtatcacgc ccatattgag tcaaatcggt ggtttgaact ttacctccta gtggtacacc 19741 aagacgaatt ctgaagtatt ttccaaggat gctgttgtca tggctggact ctagggcttt 19801 attgttgtct tgtgcgacaa cacagacaaa actctgaccg tcatctgtaa tcagattaaa 19861 ctcgtgctta cgtggaggaa aaaaaccggg attttgttga tgaatagcgc taggaattgg 19921 aatgtatgct tgattgggtt cccttccgtg tcgctggccc caattcaatc cgcttttttc 19981 atgaacttct ctgttctggt tcaccatgac caatggtagg gtaacgaact gccggtcccc 20041 aatgatatga ttaacagcac cggcatctat gctactagat tgtggtgatt gctgaaatcc 20101 catggtaaaa tactgaaaca catcgggtga ggtacagtct actagatcgt cacatggagg 20161 aaaagctgct cttatctcat cggaatttgc attgacaaga atctcctggt agtcccgaaa 20221 tccatgccag gataaatttg ctgaacctgt gtaaactctt tcggcatctc cgttctctcc 20281 acgccagaca aaaatcttag aatgaattgc cggtcttccg ttgtaataac gtacacggag 20341 tctcccggta ttttcgcaaa ggttcacgta ctcattatga tcccatatcg aaatattatc 20401 ttgcttagcc atgccaagga ttacatcgag atgaatattt tcataggtgt agattaagtg 20461 gtgtacaaaa ctggaagaag catatccagt cagtacttcc aatcttcgca acccgagggc 20521 ataattttga ttgattacat catcataaag tcgtgggtaa atgggcataa acgacactcc 20581 attgcgaaat ttcgaaaaat aagttcactt atattatatt accataacct tgaggttcgg 20641 taaccctaaa tcttctttgt tacaaaagta tataggaatg tttacctata tttctaatta 20701 tgcttattaa gaaaaaaaaa atcccttttt tgaaagggac gtcaagaaat tattatagaa 20761 aaagtgagtc tattttttgc tctaacatct gctctacatc ccattttggt ttaatggaat 20821 catattctac tccggcgtag gttttcaaaa cggcttcaat gatgatacga gcaccctccg 20881 gcggaactgc cataccaact tgttggcgca ctttttcctt tgtcccatga aaataaaatt 20941 cgtctggaaa ggtttgtagt cgtgctcgct ctcgatttgt caacgccctc ggttcctccc 21001 agtgatacat atgtgtacca cctccaccac tcccagttac agtataagat ggagtgtttt 21061 tctccaagcg tcggtaaatc tggctcattt ttgcaccttt gacattgagg cgtaagtctt 21121 caggtatgcc atcgtaccaa gcattttgtc ctgcaggaat agctttcaaa aattcaatga 21181 cttttggttt atgctttggc atatcgttgt tatatgcatt ctctaatatc ggtggctcca 21241 ttattgcgtc gtatgcggtt ttgtaaggat gtggtctatt agggccgtga gttggagctg 21301 gcaccctaaa ctccatgttt aaatctttgc gaaaaccgat aatcaagatt ctttgccgtg 21361 tctgaggcac accataatct gcaaagttgt atagatgcgg agttagcttg taaccagctt 21421 cattcatttc cgatagaatt tgaagaaatg ccttaccttc attcgcactc tgtagcccac 21481 caacattttc agcaataaac cacttaggtt gatagtgttt tagtacacgt attccataac 21541 tataaagcgg accataggta ccatcaaatc cctttttctc tcctacgatg ctaaaatcat 21601 tgcatggaaa gccatagata aaagcatcaa tttcacctaa ttcctccaag ttaagtagcc 21661 ttacatcccc acgatgaacc gattccggtt tatccgggca aatattgtgg gtatacgtat 21721 cacatgcact gtcgcagtaa tcgttcgacc aagtatgttc gacggcatag gtcataccat 21781 ttgcttctac ccgagcattt tttgcgcccc aggcgaatcc tccgggtcca ttaaataatt 21841 caccttttcg aaagatcatt tttgcctccc cttgccgtac taactaatat attttactat 21901 tataccactt cttttatcat ttatcgacgc ccaaaaggaa catacgttct caattaaaga 21961 cagaaactta taccatacta gtagaggagt tctgaggttt ctcgttatat attgctattg 22021 tttgtaatat tatagcgcaa tatttctaca tagtagaatg taaatattct ggcttgattt 22081 gtattagcca tgttgtactt cccagataga aatgcaactc caaacctttc tggtttttga 22141 aaggagcctc cttcctcttt ttcaagtaat ttcgagaata tccggctcct tgtctttctc 22201 caaaaaaacc tttcaattca caaaagccaa gcttggaaat aaaacttgta attaacttga 22261 ttcaactata aataaaaata gacaacagat tatctgatgt ctattatttt gtgatttaaa 22321 cgataatttt gccgctaatt taatcaaatt tttgccagaa a //