LOCUS NZ_CP018145 76889 bp DNA circular CON 05-MAR-2024 DEFINITION Brevibacillus formosus strain NF2 chromosome, complete genome. ACCESSION NZ_CP018145 VERSION NZ_CP018145.1 KEYWORDS RefSeq. SOURCE Brevibacillus formosus ORGANISM Brevibacillus formosus Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus. REFERENCE 1 (bases 1 to 6437015) AUTHORS Fu,B. and Li,Z. TITLE Direct Submission JOURNAL Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: HGAP v. 3 Genome Coverage :: 167.68 Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 03/05/2024 02:46:36 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.6 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,168 CDSs (total) :: 5,986 Genes (coding) :: 5,821 CDSs (with protein) :: 5,821 Genes (RNA) :: 182 rRNAs :: 16, 17, 17 (5S, 16S, 23S) complete rRNAs :: 16, 17, 17 (5S, 16S, 23S) tRNAs :: 127 ncRNAs :: 5 Pseudo Genes (total) :: 165 CDSs (without protein) :: 165 Pseudo Genes (ambiguous residues) :: 0 of 165 Pseudo Genes (frameshifted) :: 85 of 165 Pseudo Genes (incomplete) :: 95 of 165 Pseudo Genes (internal stop) :: 22 of 165 Pseudo Genes (multiple problems) :: 35 of 165 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 14:35:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 2473962 Orig. end :: 2550851 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to CP018145.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ This genome has a base modification file available. COMPLETENESS: full length. FEATURES Location/Qualifiers region 1..76889 /candidate_cluster_numbers="1" /contig_edge="False" /product="transAT-PKS" /product="NRPS" /region_number="10" /rules="(cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))" /rules="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /tool="antismash" cand_cluster 1..76889 /SMILES="NC(CC(=O)N)C(=O)NC([*])C(=O)NC([*])C(=O)NC([*])C(= O)NC([*])C(=O)C(C)=CNCC(=O)CC(=O)C(=O)O" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))" /detection_rules="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /kind="chemical_hybrid" /product="transAT-PKS" /product="NRPS" /protoclusters="1" /protoclusters="2" /tool="antismash" protocluster 1..53350 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[20000:33350](-)" /cutoff="20000" /detection_rule="(cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))" /neighbourhood="20000" /product="transAT-PKS" /protocluster_number="1" /tool="antismash" proto_core complement(20001..33350) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))" /neighbourhood="20000" /product="transAT-PKS" /protocluster_number="1" gene complement(45..746) /locus_tag="BP422_RS11315" /old_locus_tag="BP422_11000" CDS complement(45..746) /EC_number="3.1.3.5" /GO_function="GO:0008253 - 5'-nucleotidase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) HAD_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249042.1" /locus_tag="BP422_RS11315" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11000" /product="YjjG family noncanonical pyrimidine nucleotidase" /protein_id="WP_088907812.1" /sec_met_domain="HAD_2 (E-value: 1.9e-23, bitscore: 81.9, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MRYQVILFDVDDTLLDFKTTEENALQKTFAQFGLATGSFDYRATY KEISKGLWEDLEKGRITLAELGVERFRRLFKAVQLDVDAEAFGSAYLESLGKEVHLVPG AVELCNSLEDCRLVIITNGFASVQTARIAASPLCNAFEHLIISEEVGYKKPDREIFEYA FAKLQWTEKANVLMVGDSLTSDIQGGANYGIDTCWFNPLGKENQTSIQPTYEIRELSEL QEIVRKGNVNL" gene 866..1003 /locus_tag="BP422_RS32085" CDS 866..1003 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS32085" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_236841367.1" /transl_table=11 /translation="MKDMLEKRLLDQRRDFESMNMTIVERGRSTYKMNMSLKPRWTFSF " gene 1376..1903 /locus_tag="BP422_RS11325" /old_locus_tag="BP422_11005" CDS 1376..1903 /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1027: isochorismatase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743561.1" /locus_tag="BP422_RS11325" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11005" /product="isochorismatase family protein" /protein_id="WP_088907814.1" /transl_table=11 /translation="MKALLVSDVQNGIVNCGDYKEELFLMEQVIKDFKASNRPVIFIRH IDDAEESPLNRSSIGSEIHPSLKGYSDYLIEKQTPSSFFQTELTQTLEKLEVDQLFMIG FETEFCCMFTAIAAYDRGYKVTFIKDATGTTNTAESYGMQGLDIKRFVGTVLRWSSVIE VVDYAEYAEKYK" gene complement(2171..4774) /locus_tag="BP422_RS11330" /old_locus_tag="BP422_11010" CDS complement(2171..4774) /GO_component="GO:0016020 - membrane [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727289.1" /locus_tag="BP422_RS11330" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11010" /product="ABC transporter permease" /protein_id="WP_088907815.1" /transl_table=11 /translation="MNIVNQLTLRYMKKNKSRTLVTIIGVVISVAMLTAVFSISSSFMD MMQRNTIAYAGKWQAAFLDVAGEDVAVITNTEAIERYDIDQKLGFARLSNSPNSVKPYL YITGHSNHDVIGVGLIDGRLPQNENELALSSQFLQTAGVSWKVGDVVTLDFGNRSLNID GKSETLGTDYVYQSKEVFTPTKTKTYTITGIVQAPDKEQEAMAAYRAFSGLSEGDLEEG FPYTVSVEYKDFKGLGNNIYETSNTIASKVSGVKDQVKSNGVKVKYNRDLLLYSGISND SHFLNTMYLAVLSVGSIILIGSVSLIYNAFAISLSERSRTLGMLSSIGATKQQKRASVF FEAAVIGVIAIPAGLFFGSIGIGVTLHLLSPFIQKMFVVSEPMRLVIEPFSMVAVILFS VLTLFISAWFPAVRASGITPITAIRQTKDIEIKGKDVRTSKMTRKLFGFEAELGLKNLK RNKHHYRSTVFSLAISVILYLAASSFSLYMDKSYNMAQAPLPYDLSVYARGADLERVRS LTNELMSVQNATTKVNTQLIGAALFLNENEVTTDISSRHTLDPEGKYFMTANIVSLDDA SFVAYLQSAGIDAKKLEGDEISAILVNRFTLKEQHNFTDITQLTVQEGSEIPLSNTLIE GAKVRIASITDKRPPFMLRYQEDAFTVTLVVSERGFDKLRELGNDKLSEQIFSEVQFTT EQSAALENEINPIINEYPDVHVYTTNLIEERQDAMNRATVISVFLYGFVILIGLICMAN IINTISTGMALRKREFAMLASIGMTPKGMKKMLRFEGFFYGMKSLIYGLPISLCVMFFI YKSLSRNFEFAFTLPWANLLIAGIGVFFIVGTSILYATRKHKEQNIVEALKNENI" protocluster 4693..76889 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="False" /core_location="[24692:56889](-)" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /neighbourhood="20000" /product="NRPS" /protocluster_number="2" /tool="antismash" proto_core complement(24693..56889) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /neighbourhood="20000" /product="NRPS" /protocluster_number="2" gene complement(4771..5454) /locus_tag="BP422_RS11335" /old_locus_tag="BP422_11015" CDS complement(4771..5454) /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727286.1" /locus_tag="BP422_RS11335" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11015" /product="ABC transporter ATP-binding protein" /protein_id="WP_088907816.1" /transl_table=11 /translation="MEILRVENLSKTYGDGETAVTALNDISFSVQKGEFVAIIGPSGSG KSTLLHILGGVDTPTSGKVIVDQTDMYAMDETALAIFRRRQIGLIYQFYNLIPVLTVEE NITLPLLLDGREVNQEIFSGIVETLGLQQRLKHLPNQLSGGQQQRASIGRALISSPAIV LADEPTGNLDSKNSAEIVKLLKKLHKERHQTLIVITHDETIALQADRIIGIQDGRISRD EVIRR" gene complement(5540..6541) /locus_tag="BP422_RS11340" /old_locus_tag="BP422_11020" CDS complement(5540..6541) /GO_function="GO:0000156 - phosphorelay response regulator activity [Evidence IEA]" /GO_function="GO:0004673 - protein histidine kinase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0007165 - signal transduction [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1003: sensor histidine kinase" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016739678.1" /locus_tag="BP422_RS11340" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11020" /product="HAMP domain-containing sensor histidine kinase" /protein_id="WP_088907817.1" /transl_table=11 /translation="MLKNKEIRKLCMYSVVISIIGITILWIIDWKAGIVAIAMVFLLLS CFFLFTRKRYQDISKLAYYLASVYSGQPTMDIRDNVEGELSILKNDIYKVTLTLSEQST LLKKDKQYLAETLSNISHQLKTPLASMFVMADLLNNPSLPKEKREEFLGKIINQLKRIE WLVTSLLKLSKIDVQSVIFKKELVSVKKMINKALEPLLVPMELKNQELSFSCKEDLFVY GDANWTVEAILNVIKNGIEHTPVGGRIAISCEETPLYTQIVIADSGEGISPEDAPRIFE RFYKGKNAGVDSIGIGLAMSKTILQSQNADVFMESQFGVGTTFKIKFYKQMM" gene complement(6534..7220) /locus_tag="BP422_RS11345" /old_locus_tag="BP422_11025" CDS complement(6534..7220) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1008: response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017247084.1" /locus_tag="BP422_RS11345" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11025" /product="response regulator transcription factor" /protein_id="WP_088907818.1" /transl_table=11 /translation="MKVLVVEDDKTIADGLHYSLSSEGYEVVLCEGKHTAIETIRQQRF DIYLLDLTLPDGNGYEICEFVKENQDAPVIFLTACDDEINVVRGLDMGADDYITKPFRI RELISRMKSSLRHYQKEPNLTDKVKIGNVVVNTKLAKVYKGTEEVMLTALEYRLLLAFI NSRGQVLSRNQLLEGIWDLDGNFINDNTLSVYIKRLREKLEDDSQNPKVIETVRGLGYR MSGSYA" gene 7461..7835 /locus_tag="BP422_RS11350" /old_locus_tag="BP422_11030" CDS 7461..7835 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727277.1" /locus_tag="BP422_RS11350" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11030" /product="DoxX family protein" /protein_id="WP_088907819.1" /transl_table=11 /translation="MIGLRIFAKWVMIVGLCLMFLSSGIYKLFGHPETTIAFQAFGFPH WFQVVIGLGEMLGGLGLLMKKYTRYAAYTLAVIMLGATITLLLHGDTTTVAIPFVLLLV FLLIGRQSGSKKKSNHATSI" misc_feature complement(7479..7493) /note="TFBS match to SypG, Regulator of biofilm formation and host colonization, confidence: weak, score: 21.31" /tool="antismash" gene 8205..8414 /locus_tag="BP422_RS11355" /old_locus_tag="BP422_11035" CDS 8205..8414 /GO_component="GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]" /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249053.1" /locus_tag="BP422_RS11355" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11035" /product="CDGSH iron-sulfur domain-containing protein" /protein_id="WP_088907820.1" /transl_table=11 /translation="MDQEKVTIKINDNGSIRVTGAVELLDGASDKYDVGSSFSLCRCGQ SEKKPFCDGTHKKVGFESAPRAKS" misc_feature 8591..8609 /note="TFBS match to LexA_variant_3, Repressor of DNA damage response, confidence: weak, score: 22.91" /tool="antismash" gene 8593..9576 /locus_tag="BP422_RS11360" /old_locus_tag="BP422_11040" CDS 8593..9576 /NRPS_PKS="Domain: PKS_ER (20-326). E-value: 4.3e-28. Score: 90.3. Matches aSDomain: nrpspksdomains_BP422_RS11360_PKS_ER.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727274.1" /locus_tag="BP422_RS11360" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11040" /product="zinc-dependent alcohol dehydrogenase family protein" /protein_id="WP_088907821.1" /sec_met_domain="ADH_N (E-value: 2.3e-06, bitscore: 25.9, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 7.4e-15, bitscore: 53.6, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MYAQTVRYDQFGEPREVLKVEQRLIQPLKHDEILVKMSARPINPS DVIPIRGAYKHRINLPAIPGYEGVGTVMDTGPFAPLSLIGKRVLPLRGEGTWQEYVKTT AELAIAVPDSIPDDIACRLYINPITAWVICNETLQLSSHQVLLVNAANSAIGRLFIQLS ALFGFRVIAIVRDAKYTEELMQLGAWHVIDSSHVSIYDAIMSVTNGQGAHASIDSIGGP DGLELAKSTRAGGMFLSLGLLSGVQVDWSIISKELGVLPQLFLLRHWNQRISVSTWHET FEKVIELVQNGQLLLAEPGEKFALHEVIEAVQFAESRHRTGKIILV" aSDomain 8653..9570 /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11360_PKS_ER.1" /evalue="4.30E-28" /label="BP422_RS11360_PKS_ER.1" /locus_tag="BP422_RS11360" /protein_end="326" /protein_start="20" /score="90.3" /tool="antismash" /translation="EQRLIQPLKHDEILVKMSARPINPSDVIPIRGAYKHRINLPAIPG YEGVGTVMDTGPFAPLSLIGKRVLPLRGEGTWQEYVKTTAELAIAVPDSIPDDIACRLY INPITAWVICNETLQLSSHQVLLVNAANSAIGRLFIQLSALFGFRVIAIVRDAKYTEEL MQLGAWHVIDSSHVSIYDAIMSVTNGQGAHASIDSIGGPDGLELAKSTRAGGMFLSLGL LSGVQVDWSIISKELGVLPQLFLLRHWNQRISVSTWHETFEKVIELVQNGQLLLAEPGE KFALHEVIEAVQFAESRHRTGKIIL" misc_feature complement(9715..9732) /note="TFBS match to ArcA, Repressor of carbon oxidation, confidence: weak, score: 18.4" /tool="antismash" gene 9793..10185 /locus_tag="BP422_RS11365" /old_locus_tag="BP422_11045" CDS 9793..10185 /GO_component="GO:0016020 - membrane [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891474.1" /locus_tag="BP422_RS11365" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11045" /product="YkvA family protein" /protein_id="WP_088907822.1" /transl_table=11 /translation="MATHEKRFLKNYESKASKYLNDKEKASNLLKKAMKKADKKTIGDA WENLQLLFQIFGDWTSGKYRTIPVKSILMIIGGILYFVSPVDAITDFIPVAGLLDDATI IGLVFRQVSSDLTLYKEWKQKEFLQE" gene 10219..>10686 /locus_tag="BP422_RS11370" /old_locus_tag="BP422_11050" /pseudo="" CDS 10219..>10686 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_001238786.1" /locus_tag="BP422_RS11370" /note="incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11050" /product="hypothetical protein" /pseudo="" /transl_table=11 /translation="MTFHEYLRHTFPTLMLRPPLFYSWDIGIRFELGVDYDYHNVYENG PYLQGVYTRAITLCKTLHAPNDDIYIVVDVNDFGDGGAFKRKLNVFSKYVKNKSLLYKL QQNTIPYVFPEDDENEVYRTHRFALKCKTSDFSYVPMIKAICRQDMGLQPRI" gene complement(10734..11651) /locus_tag="BP422_RS11375" /old_locus_tag="BP422_11055" CDS complement(10734..11651) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1039: aldo/keto reductase family oxidoreductase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009224607.1" /locus_tag="BP422_RS11375" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11055" /product="aldo/keto reductase" /protein_id="WP_088907823.1" /transl_table=11 /translation="MRTIPLGTTKLEVPVIAIGCMRIGSLDKLQAERFVQTALEEGANF FDHADIYGKGRCEEVFAEAIQMSSSVRERILLQSKCGIRPGMFDFSKEHILNAVDGILK RLKTEYLDVLLLHRPDTLVEPEEVAEAFDLLESTGKVRHFGVSNQNPMQIQLLNKHVKQ PIVANQLQLSIMNATMISQGFNVNMENNSAVNRDGSVLDFCRLHDITIQPWSPFQHGFF EGSFLGNEKFPELNKKIDEMAARYEVSNTTIAIAWLLRHPANMQPVIGTTNIDRMKDSV KAAHIRLTREEWYDIYRAAGNVLP" gene complement(11919..12206) /locus_tag="BP422_RS11380" /old_locus_tag="BP422_11060" CDS complement(11919..12206) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019913474.1" /locus_tag="BP422_RS11380" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11060" /product="hypothetical protein" /protein_id="WP_088907824.1" /transl_table=11 /translation="MSRSYKKFPVVKDKSGPAKKFAKRLSSKAVRRYSAGIHAGRMYRK IFCSWNINDFWFYKSFREAIRDWETSDVPKVKAKAKKQIINEWAKYYYRK" tRNA complement(12398..12471) /anticodon=(pos:complement(2486399..2486401),aa:Gly, seq:ccc) /inference="COORDINATES: profile:tRNAscan-SE:2.0.12" /locus_tag="BP422_RS11385" /note="Derived by automated computational analysis using gene prediction method: tRNAscan-SE." /old_locus_tag="BP422_11065" /product="tRNA-Gly" gene complement(12398..12471) /locus_tag="BP422_RS11385" /old_locus_tag="BP422_11065" gene complement(12603..15662) /gene="edeA" /locus_tag="BP422_RS11390" /old_locus_tag="BP422_11070" CDS complement(12603..15662) /codon_start=1 /gene="edeA" /gene_functions="biosynthetic-additional (smcogs) SMCOG1053: beta-lactamase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003337650.1" /locus_tag="BP422_RS11390" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11070" /product="cyclic peptide edeine export ABC transporter EdeA" /protein_id="WP_205669478.1" /transl_table=11 /translation="MLMCLVLVLSSSMSVYAETNDRQDPEIATEIEQLVNKTMESEKIP GAAVVVVKEGKTIYKQSFGFSDTQKQEPVTSDTLFEIGSNSKAFTALAVHQLVDQKRLS LEDPVQNYIPWFRVTYKGQQETILIKHLLYHTSGIPFESIGSIPISSSENAIEETVRAI NHTELVRKPGTEYEYATINYDILGYVVEKITGETYEQYVQQQVIAKLGLTHTFLKAQAP VEEMARGHKIEFFSPRVYDAPEYRGNTPAGYVVSDLNDMERWLQIQLGWEASAFRPELV RASHLPDRSVAPATDGFSYASGWMIYQDGGGQISHGGNNPAFSSYMVFRPEEKLGAVVL TNINSLNASVIAEGAVNLVLGKEAPVVVSDTNLQADRLASISLVILGILLLLLGGAIVQ IFVQVYRGERKLSANAGRICFASFVAFVVMGSVLTAALYYLPDVFFMGLPWPFIEVWLP ITIFYAMYALVAGLALFNVYITLIRLFPKSQETSMTSIVIQGLISGFGNALIIFMINLA LTSTNKFHASIFLYFLLGILLYIVGEKMMRSRLIVITNEIVYEKRMELIRKIFRTSYQK YETLDNGEIYAGLNNDTETISTFANSVVVALTSAVTLVFCFIYLGSLDLYGFLFCLAVI FVAVGLYTLAGRFANKVWEETRDIQNVFFSYITDMIGGFKELYLTQAQRKEFEADMERS CSDYRHKKSAGQFKFVNVYLIGELLFVVVIGTVAFLFPVLFPSLQKEMLISYVFVFLYM TGPVHGILNAVPELIRIKISWQRLNALLDSLSVETRRGEESLVERNAQDFETFSTEQVR FQYKNKEGEEFSVGPLDFSCRKGEIVFIVGGNGSGKSTFAKLITGLYEQDEGEFFMNGQ KVNADQRCEFFSAIFSDFYLFEKMYGIDYQAKQEEVSKYLEVLRIADKVEVDETGTFST TKLSTGQRKRLALMLSLVRDRPIFLFDEWAADQDPEYRQFFYESLLPEMKRQGKCVIAI THDDRYFHLADQVVKMESGRIILQQTLAHA" gene complement(15817..16578) /locus_tag="BP422_RS11395" /old_locus_tag="BP422_11075" CDS complement(15817..16578) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727256.1" /locus_tag="BP422_RS11395" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11075" /product="ParB N-terminal domain-containing protein" /protein_id="WP_236841446.1" /transl_table=11 /translation="MLANLKLVESSRICLHESHENKRLHKTRQIIEEEGILRHPPLAIL MQNGQYLIIDGAHRTFALQALGCKHIPVQIVEHEDFHLDMWDHIVPVAAWLQSVEQDSV FRWETERLGETPVAEMKIGNKERFYLYPNENRQDDEWRMTLWRQLVDSYNYSHPVHRLP TGMLEWPETGAALIRFPPISLAELERIVSEGHVLPAGVTRFEIDGRLLNLCIPISLLKQ EQIEQEQWERLVKKWRETLRLYSKPVYMCDA" gene complement(16603..17571) /gene="sbnB" /locus_tag="BP422_RS11400" /old_locus_tag="BP422_11080" CDS complement(16603..17571) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_process="GO:0009058 - biosynthetic process [Evidence IEA]" /codon_start=1 /gene="sbnB" /gene_functions="biosynthetic-additional (smcogs) SMCOG1158: ornithine cyclodeaminase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727255.1" /locus_tag="BP422_RS11400" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11080" /product="2,3-diaminopropionate biosynthesis protein SbnB" /protein_id="WP_088907826.1" /transl_table=11 /translation="MLYLNTSDIEKVGKNWKETIDVIEHAVHSLHKEDYAQPIKPYLRY HDMSNRIIAMPAFVGGDTYMAGIKWIASFPKNLQEGIQRAHSITILNEARTGKPVATIN TALVSGIRTASVSGLLLKHYEQVRPLQNVTVGIIGFGPIGRLHLQMVTSLLGEKIDKVV LYDIAGIQQEHIPAEIKEKTVIAQTWEEAYCEGDVFITCTVSPHGFIDKQPKRHSLLLN VSLRDFTPKILDYTRSIIVDDWTEVCRENTDIEIMHLERGLQKEDTKSITDIVCLDQMK EFPQDEPIMFNPMGMAIFDIAIAAYYYKQALSQGIGTHLQD" gene complement(17617..18585) /gene="sbnA" /locus_tag="BP422_RS11405" /old_locus_tag="BP422_11085" CDS complement(17617..18585) /GO_function="GO:0030170 - pyridoxal phosphate binding [Evidence IEA]" /GO_process="GO:0009058 - biosynthetic process [Evidence IEA]" /codon_start=1 /gene="sbnA" /gene_functions="biosynthetic-additional (rule-based-clusters) PALP" /gene_functions="biosynthetic-additional (smcogs) SMCOG1081: cysteine synthase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727254.1" /locus_tag="BP422_RS11405" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11085" /product="2,3-diaminopropionate biosynthesis protein SbnA" /protein_id="WP_088907827.1" /sec_met_domain="PALP (E-value: 6.4e-54, bitscore: 181.8, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MLTKMMAISHMIGNTPLIKLEHEHINLFCKLEYNNLMGSVKVRAA FYILQEAIKRGEITQETTVIESSSGNFAIALATLCKQIGIKFIPVIDPNINPVYENLLR AFSHEVVKVTDRDETGGFLLTRIQTVNRLLNETNNSFWTNQYGNPDSARAHYFGLGAEI ADSFETLDYAFIGVSSGGTITGISQRLKERYPNIKIIAVDTVGSVIFGQEPQKRYIPGI GSSMRPDILKGAIIDEVVHVSEEDTVKACYQLYAEHGIFAGGSTGTSYWAIKNYFKDQK HVVKPNVVFLCPDGGMPYVNTVYNQEWVQWLHQQKHSFVGN" gene complement(18652..18888) /locus_tag="BP422_RS11410" /old_locus_tag="BP422_11090" CDS complement(18652..18888) /NRPS_PKS="Domain: PP-binding (28-66). E-value: 5.7e-07. Score: 21.7. Matches aSDomain: nrpspksdomains_BP422_RS11410_PP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727253.1" /locus_tag="BP422_RS11410" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11090" /product="phosphopantetheine-binding protein" /protein_id="WP_088907828.1" /sec_met_domain="PP-binding (E-value: 0.00011, bitscore: 21.1, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MEKENEVYETLLQLFSEYVNESGELAEYIDSLTFIKSVVKVEKEF GIEFDDDMLHLENFQDMKMLAGYIQQKMDAKSA" aSDomain complement(18691..18804) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11410_PP-binding.1" /evalue="5.70E-07" /label="BP422_RS11410_PP-binding.1" /locus_tag="BP422_RS11410" /protein_end="66" /protein_start="28" /score="21.7" /tool="antismash" /translation="IDSLTFIKSVVKVEKEFGIEFDDDMLHLENFQDMKMLA" gene complement(18914..19957) /locus_tag="BP422_RS11415" /old_locus_tag="BP422_11095" CDS complement(18914..19957) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743549.1" /locus_tag="BP422_RS11415" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11095" /product="BtrH N-terminal domain-containing protein" /protein_id="WP_088907829.1" /transl_table=11 /translation="MSLAEIQPSKHPNLDCIGASIFTVLKYLNFSALETAWKQCGAIYL KTQDSPYGDLNGQYMRTVRELKWIHNICVEGRAEPENDLFLANIQERLEREVPTIVLCN MAELPYNPYYQDLPEMHSIIVTGREDNQLLIVDDYYRYKGLLPIEQFLQASNSSYRDAG TGEWYPLHNRSFELVLSDSLHPTPEQLLEAVRSNLCVLEGRYETSQIKRELDVPDDANV EVGLKSLDPFLKDVEAFLASGVEITDDHLDILNHSLISMAQTRAMYANVLQVISEKHQN FADLAELYRNIGHQWKITTNMILKAFDSNRCDMVHRVLQKISSIKTQEFEAVTKTRVAL ERGGVVV" gene complement(20001..23366) /gene="edeG" /locus_tag="BP422_RS11420" /old_locus_tag="BP422_11100" CDS complement(20001..23366) /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (30-457). E-value: 1.1e-159. Score: 523.8. Matches aSDomain: nrpspksdomains_BP422_RS11420_PKS_KS.1" /NRPS_PKS="Domain: Trans-AT_docking (470-640). E-value: 3.5e-22. Score: 71.4. Matches aSDomain: nrpspksdomains_BP422_RS11420_Trans-AT_docking.1" /NRPS_PKS="Domain: PCP (686-754). E-value: 3.9e-23. Score: 73.4. Matches aSDomain: nrpspksdomains_BP422_RS11420_PCP.1" /codon_start=1 /gene="edeG" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: hyb_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: ATd" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_087349105.1" /locus_tag="BP422_RS11420" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11100" /product="edeine polyketide synthase EdeG" /protein_id="WP_088907830.1" /sec_met_domain="hyb_KS (E-value: 3.6e-158, bitscore: 525.4, seeds: 33, tool: rule-based-clusters)" /sec_met_domain="ketoacyl-synt (E-value: 2.6e-74, bitscore: 248.4, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="ATd (E-value: 3.5e-20, bitscore: 71.4, seeds: 19, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 9.3e-13, bitscore: 46.9, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSKPLGLNRVKLNKQQTDAHSTDSKPNQHDIAVIGAACRFGSAEN PADFWRLLQAGQDCVRELPKERQNDLIPLLLAKGLTMEQIQFREAAYLNEIDKFDPQFF GLSPKEASQMDPNQRLFLLTCWEAIEDAGYGGTMLAGSRTGVYLGFSSDFGEEYKRMIR ELEPDALSTSIIGNMKSVIASRISYLLDLKGPSMLVDTSCSSSLMAVHLACQAIRRGEC EMALAGGVKLILMSLQDGSNDLGILSQSGRTRPFDNDSDGTGVGEGVGAVLLKPLTKAL ADGDSIYAVIKGSAANQDGHSFGLTAPNSLAQAEVIQQAWKDAQIDPETLSYIEVHSIG TKLGDPMEMDGLERAFRPYTNRRQFCGIGSVKTNIGHTDHVAGMAGLFKVILSLKQKQI PPHLHFQRANRMIPFEQSPIYIHDTLTEWEPEQSVRRAGISSFGMSGTNVHLVVEEAPF IQPPKPDEGVQAIALSAKSKESLLSLLLRFQKWTSKPVEELPTLESLSFTANTGRSHYG YRLLLICKDMDDFAAKISKLCASDWTTLSDPDIFFGWHKVISQEKADREPGILTEAEQQ AINKAANAVLQKLLLAQSKELSDLKELGELYVSGADVRWSTMYTFKKPRRVHLPVYPFE RKRCWLDISSLHSLGEDAGKQKDNVAPQKSGEAKLANVVVRGRKDDTYTVLEQELAQTW GYVLGLEEVDVHDNFYDLGGDSIIAIKMISEISKRMNREVAVQDLLTHLTISDFAAYLD AAGSEEEQVPKAEAAATAIQTTQQRNENSWQGTQIKRSSYADVSHLSWRQWNCYDRGLA LLMEEQDAHLIPYLKLFLGLKRGYQLGAEGYPYSYREHAEVMGYLSDEEMLYKFGYRVK LVPVARLDELHESIIRQLDQGKPVMVAFDEYYTFYTPQYQKEHTDHLTVITGYDHDKQV YTIINHNHLTRGQAQRIQYDKFSTTYQTLEEIYANLEPHSRLIMVLDRVTDDEASLRAS AEQELLRLLKAVESKQQVGRELTLLLSLTEQPDTYFHEANLNELYVQLGGKELWIETLV DWYIPRADQSVRELAEEILQTSNNVVNRYALSLYKEKMLNRSDLEAAVDKLRSLTSQFL QQVFALRERDSDIR" aSDomain complement(21105..21308) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11420_PCP.1" /evalue="3.90E-23" /label="BP422_RS11420_PCP.1" /locus_tag="BP422_RS11420" /protein_end="754" /protein_start="686" /score="73.4" /tool="antismash" /translation="EQELAQTWGYVLGLEEVDVHDNFYDLGGDSIIAIKMISEISKRMN REVAVQDLLTHLTISDFAAYLDA" aSModule complement(21105..23276) /complete /domains="nrpspksdomains_BP422_RS11420_PKS_KS.1" /domains="nrpspksdomains_BP422_RS11420_Trans-AT_docking.1" /domains="nrpspksdomains_BP422_RS11420_PCP.1" /locus_tags="BP422_RS11420" /monomer_pairings="mal -> mal" /tool="antismash" /type="pks" aSDomain complement(21447..21956) /aSDomain="Trans-AT_docking" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11420_Trans-AT_docking.1 " /evalue="3.50E-22" /label="BP422_RS11420_Trans-AT_docking.1" /locus_tag="BP422_RS11420" /protein_end="640" /protein_start="470" /score="71.4" /tool="antismash" /translation="IALSAKSKESLLSLLLRFQKWTSKPVEELPTLESLSFTANTGRSH YGYRLLLICKDMDDFAAKISKLCASDWTTLSDPDIFFGWHKVISQEKADREPGILTEAE QQAINKAANAVLQKLLLAQSKELSDLKELGELYVSGADVRWSTMYTFKKPRRVHLPVYP FERKRCW" aSDomain complement(21996..23276) /ASF="found active site cysteine: True, scaffold matched GSSS: True" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11420_PKS_KS.1" /domain_subtypes="Hybrid-KS" /evalue="1.10E-159" /label="BP422_RS11420_PKS_KS.1" /locus_tag="BP422_RS11420" /protein_end="457" /protein_start="30" /score="523.8" /tool="antismash" /translation="IAVIGAACRFGSAENPADFWRLLQAGQDCVRELPKERQNDLIPLL LAKGLTMEQIQFREAAYLNEIDKFDPQFFGLSPKEASQMDPNQRLFLLTCWEAIEDAGY GGTMLAGSRTGVYLGFSSDFGEEYKRMIRELEPDALSTSIIGNMKSVIASRISYLLDLK GPSMLVDTSCSSSLMAVHLACQAIRRGECEMALAGGVKLILMSLQDGSNDLGILSQSGR TRPFDNDSDGTGVGEGVGAVLLKPLTKALADGDSIYAVIKGSAANQDGHSFGLTAPNSL AQAEVIQQAWKDAQIDPETLSYIEVHSIGTKLGDPMEMDGLERAFRPYTNRRQFCGIGS VKTNIGHTDHVAGMAGLFKVILSLKQKQIPPHLHFQRANRMIPFEQSPIYIHDTLTEWE PEQSVRRAGISSFGMSGTNVHLVVEEAP" CDS_motif complement(22218..22262) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11420_0002" /evalue="5.70E-03" /label="PKSI-KS_m6" /locus_tag="BP422_RS11420" /protein_end="383" /protein_start="368" /score="9.6" /tool="antismash" /translation="GSVKTNIGHTDHVAG" CDS_motif complement(22740..22787) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11420_0001" /evalue="4.80E-06" /label="PKSI-KS_m3" /locus_tag="BP422_RS11420" /protein_end="209" /protein_start="193" /score="18.6" /tool="antismash" /translation="GPSMLVDTSCSSSLMA" gene complement(23408..24676) /gene="fabD" /locus_tag="BP422_RS11425" /old_locus_tag="BP422_11105" CDS complement(23408..24676) /EC_number="2.3.1.39" /GO_function="GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: PKS_AT (6-287). E-value: 1.2e-66. Score: 217.0. Matches aSDomain: nrpspksdomains_BP422_RS11425_PKS_AT.1" /codon_start=1 /gene="fabD" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PKS_AT" /gene_functions="biosynthetic-additional (smcogs) SMCOG1021: malonyl CoA-acyl carrier protein transacylase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891486.1" /locus_tag="BP422_RS11425" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11105" /product="ACP S-malonyltransferase" /protein_id="WP_088907831.1" /sec_met_domain="PKS_AT (E-value: 1.2e-64, bitscore: 217.0, seeds: 1682, tool: rule-based-clusters)" /transl_table=11 /translation="MDKIALLFPGQGSQYVGMGQALCEAHPIAARTFEEASDALGFNLQ TLCFAGDVQELTKTEHAQPAILTASVAAFRVYSQEMDIEPQWVAGHSLGEFTALTCAGA IQFADAVRLVYRRGQFMQAATPQGVGAMSAIFGLNAQLVEEICREHSRDGAIVVVANHN SADQIVISGHAHAVRQVEEACKQHGSTSVVSLKVSAPFHSPFMVQAAEQLNEELKRYTY CDPKWPVISNVTAQPYVHADQLVDLLTAQTISPVRWQSTMDYLVKQGANTVIELGPKNV LTNLAKGYPLRAFAFDRQGEINRYQQELQDAKTRNQAVIAQLVDSCIAIAVCTKNRGLD EEAYQRGVIAPYQALQQLRQQLEQGEKEGGYGEVREAVSLLRLILQTKKAPDAEQAMRF EQLTSKPDLQQRFPEISNEWQAS" aSDomain complement(23816..24658) /ASF="(Methyl)Malonyl-CoA specificity inconclusive" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11425_PKS_AT.1" /evalue="1.20E-66" /label="BP422_RS11425_PKS_AT.1" /locus_tag="BP422_RS11425" /protein_end="287" /protein_start="6" /score="217.0" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="LFPGQGSQYVGMGQALCEAHPIAARTFEEASDALGFNLQTLCFAG DVQELTKTEHAQPAILTASVAAFRVYSQEMDIEPQWVAGHSLGEFTALTCAGAIQFADA VRLVYRRGQFMQAATPQGVGAMSAIFGLNAQLVEEICREHSRDGAIVVVANHNSADQIV ISGHAHAVRQVEEACKQHGSTSVVSLKVSAPFHSPFMVQAAEQLNEELKRYTYCDPKWP VISNVTAQPYVHADQLVDLLTAQTISPVRWQSTMDYLVKQGANTVIELGPKNVLTNLAK " CDS_motif complement(24311..24430) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11425_0002" /evalue="6.60E-16" /label="PKSI-AT-M_m3" /locus_tag="BP422_RS11425" /protein_end="122" /protein_start="82" /score="50.4" /tool="antismash" /translation="IEPQWVAGHSLGEFTALTCAGAIQFADAVRLVYRRGQFMQ" CDS_motif complement(24611..24658) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11425_0001" /evalue="8.50E-07" /label="PKSI-AT-mM_m1" /locus_tag="BP422_RS11425" /protein_end="22" /protein_start="6" /score="21.2" /tool="antismash" /translation="LFPGQGSQYVGMGQAL" gene complement(24693..33350) /gene="edeI" /locus_tag="BP422_RS11430" /old_locus_tag="BP422_11110" CDS complement(24693..33350) /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (39-460). E-value: 1.2e-155. Score: 510.6. Matches aSDomain: nrpspksdomains_BP422_RS11430_PKS_KS.1" /NRPS_PKS="Domain: PKS_DHt (499-631). E-value: 2e-10. Score: 32.9. Matches aSDomain: nrpspksdomains_BP422_RS11430_PKS_DHt.1" /NRPS_PKS="Domain: cMT (827-990). E-value: 2.7e-36. Score: 116.3. Matches aSDomain: nrpspksdomains_BP422_RS11430_cMT.1" /NRPS_PKS="Domain: PKS_KR (1269-1463). E-value: 7.3e-47. Score: 151.6. Matches aSDomain: nrpspksdomains_BP422_RS11430_PKS_KR.1" /NRPS_PKS="Domain: PCP (1558-1623). E-value: 3.1e-22. Score: 70.5. Matches aSDomain: nrpspksdomains_BP422_RS11430_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (1640-1925). E-value: 3.8e-106. Score: 346.4. Matches aSDomain: nrpspksdomains_BP422_RS11430_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (2094-2487). E-value: 4.6e-115. Score: 376.4. Matches aSDomain: nrpspksdomains_BP422_RS11430_AMP-binding.1" /NRPS_PKS="Domain: PCP (2593-2662). E-value: 1e-18. Score: 59.3. Matches aSDomain: nrpspksdomains_BP422_RS11430_PCP.2" /codon_start=1 /gene="edeI" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_087349104.1" /locus_tag="BP422_RS11430" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11110" /product="edeine biosynthesis hybrid PKS-NRPS EdeI" /protein_id="WP_088907832.1" /sec_met_domain="ketoacyl-synt (E-value: 1.1e-70, bitscore: 236.5, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 1.8e-154, bitscore: 513.2, seeds: 44, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 4.1e-35, bitscore: 119.8, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 6.7e-14, bitscore: 50.6, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 2e-83, bitscore: 278.4, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 3.8e-122, bitscore: 406.3, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MSLLKKYILEQVAAHRLQEKEALPLLKELSSANVNTRQDIAIIGM ACRFPGANSLEEYWNNLKQGHDSIGDIPAARRPDVERVAREFFNGKDFKYERMGYLDHV DLFDHAFFEISPAEARTMDPYQRMFLELAWETFEHAGYSEKMISGSPTGVFLGYCDNES QYQRVLKNVDSSSLAGNVAAIIASRISYLLNLSGPSQLINTSCSSSLVALHQACQAIGN NDCRMALVGGVNLSLFPIQQDTDFGIVSVERKTKAFDDFADGTVWGEGLGAVLLKSYEQ AVKDNDYIHAVIKSTAVNCDGRSTSITAPNAISQSALLRTTWERARINPESISYIEAHG TGTRLGDPVEIEGIMHAFQKVSKRKQFCAIGSVKSNIGHTIAASGVAGIIKTVLMMKHR QIPPTLHVKRPNTLIPFIDSPVYINDVLKAWDVEADQPVRRAGVSAFGLSGTNAHVILE EPPGREATAISESGDYLIALSAKTSESLWDLLEKYQGFLSAPSEHSLLDMCATANIGRG HYRYRLAFIINNKEDFLQQINRLCVGERTQDGAPLVDENRVFYGELNSRGESSLPISVQ MDSSDPVEMAKQYVTGVPINWLEYYRPVKWKKVPLPTYSFAKTRHWVQSDQPANDTVER STAVASEAAHENETADVHKIASTFFTFGETLLNQVNVKKQMGLEEDETFYSGLSSLECF KKLGVFHKQDQTYTLEELREAVRFDGRNEHIFQLMLELVGKASLVEHIEGTYRLSAHAE GLDTEVFYQDCLDRYPNERDTFSQLKACFAHYSTIMSGQNVLVSNDGTSDLYKSYTDRI TLGNPSGLVVVETIAQYIHSFSRPVRILELGGGSSSLTRLLLPKIAKQDVSYLFTDGAQ SSLVEAEKQFQEVYPFVQFRPFNMELAPAEQGFDLHAYDVIIANNAIHRSKDVRASLSI LHQLLAEQGVLFAIELVKNRSTANVIGGLAADWWQHEDTDLRPQTRLMDALRWEKALRD TNYQSVAIYPSSTALGDLSDSALLIGHSAYTPQEYREWLYQIHWQTKELTTNPQNQRPG IWLVLQDEGGVGETLADAMSSEGHEVFRLRSGEAFASVSSHEFILDPGQPADLRRVFER LGEKKENLTGIIHLWSLTSGAQQPNDLGQLEALESAQHLGVYSLFHLTQALLELDLKQV LDLRIVSNYAQAVDDNGPVYPEKAPLFGLAKVISQENPKLQCFSLDLATEGLSVSQLAG QLLAEIRCNRDDTLVAYRGNRIVPEMNRCDIDKIPKRPVEIRENGVYLIAGGTGKLGLA FSKHLAAQKNVTLVLINRSPLPPNHEWQERLQHPDCSSAEARKLKALLELEEMGAQVAC YAADVSNRQQMEDISKQVRARYGPINGIIQSAAHITFETIQTKTFTHFQNGLKAKMAGT VILDQIAEPEHLDFFVIFSSLASIWGGATGSDYVSSNCFLDAYSAARSRTGKPTIALNW YAFEGITGPGFIGYMPMDGAIQAFDASLSCHTEHLIIGQFDLQVLKEWAPSLKVKLGDS IFASGMSHKEREAPPAVTMQNRVILSGREEGDHYTSLELALGQIWSDVLGYTELSIDDD FFRLGGDSLLAIGIVSRVTKQLQKEMTITDLFQTPTIRQLAMLMAPNVETAVSAIPVAE HRDAYPATSSQQRIYVLEQMQEGAVAYNIPTVMMLEGELDREAFERAFVSLVQRHESLR TSFSIVDGALMQTVQPSVDFTLAYSEVDENEAKRTVEQFIQPFDLSKAPLVRGMLIRID VNKHLLLFDMHHIVSDGVSINILIREFFQLYQGLKLPELRIQYKDYSVWQTEQLANGVL AAQEKFWQGELDGELPVLNLPTDHPRPSVQSFEGDVLTFEISQEMTEKILALAKNNGAT LYMTLLGALTIMLSKYAGEEDIIIGSPVAGRHHADLENIVGVFLNTLAMRNFPRSDRTV ADFLQEVKERALAALSHADYPFEMLVDRLMLPKDTARNPLFDVMFILQNTGDAKGSMSA NGLTLSPYPFEQRSAQFDLTFDIIEREQRLIVDIEYSNKLFSKETIASMSTHFQKILEQ MVEDPEQLIGKISMLAAEERLLLIEQWNDTSLEYSREKTVVQLFEEVAETQPNAIAVSC GDEKVTYAKLNKQANQVARLIKQQGVTADTCVGLLTNRSVEMMVGLLAILKAGAAFVPI DPHYPEERISYVLENSMARLVLTHDSLAEKQWGSVVRLDVNDSRLEMEDNSNLPSQASP GDLAYVIYTSGSTGKPKGVMVEHGNLMNFCSGIGKHIDFASADKMLAVTTISFDIFLLE TIVPLTKGMTVVIATEQQQADPQVLKELILQEEITFLQLTPSRLQLMLEEKSNLHALDC LKAILIGGEALSASLFQRLRTKTKARLYNLYGPTETTIWSTVQDLTDAEEVTIGAPLPN TQVYILDEHLQLQPIKITGDLYIAGDGVTRGYFDQPTLTAERYIPNPFQPGQRMYKTGD LARWLPDGRIEYVGRSDFQCKVRGYRIELGEIETALCQHPHITEAVVSVRDTASNPYLA AYYIGPQTLDSDELRAILSKSLPDYMIPHFYTHMSMWPLTPNGKLDRKSLPEPDALQDK HTEYQAPATRLEEQVAGIWREVLKRETVGMQDNFFQIGGNSLLLVQVHAKFEELYPGRV RIADLFAHPTLFGLTNFLKNTALDLGDEQEETDTTTHWLKELDGVSLIELPPQYWASGE ANADINWVQFSVTDDLFENVQQVSQMEAVEVRDVLLSMYLYLMAELTGQQDLYMEVAVA KELQMNAYPFRVNMSEVNTFFDLFKQVQQKRQFIENMTGEASVWLKKLRTDRNDRTIIP FFGSVNEFIDTSFTHHEHELTFWIKEGKDVIDIVCAFDPDCLRAEKVTEMTQDYQQLLR MLVNEYMT" aSDomain complement(25365..25571) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_PCP.2" /evalue="1.00E-18" /label="BP422_RS11430_PCP.2" /locus_tag="BP422_RS11430" /protein_end="2662" /protein_start="2593" /score="59.3" /tool="antismash" /translation="EEQVAGIWREVLKRETVGMQDNFFQIGGNSLLLVQVHAKFEELYP GRVRIADLFAHPTLFGLTNFLKNT" aSModule complement(25365..28430) /complete /domains="nrpspksdomains_BP422_RS11430_Condensation_LCL.1" /domains="nrpspksdomains_BP422_RS11430_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11430_PCP.2" /locus_tags="BP422_RS11430" /monomer_pairings="Gly -> Gly" /tool="antismash" /type="nrps" CDS_motif complement(25860..25925) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0014" /evalue="7.50E-11" /label="NRPS-A_a8" /locus_tag="BP422_RS11430" /protein_end="2497" /protein_start="2475" /score="34.1" /tool="antismash" /translation="YVGRSDFQCKVRGYRIELGEIE" aSDomain complement(25890..27068) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_AMP-binding.1" /evalue="4.60E-115" /label="BP422_RS11430_AMP-binding.1" /locus_tag="BP422_RS11430" /protein_end="2487" /protein_start="2094" /score="376.4" /specificity="substrate consensus: Gly" /tool="antismash" /translation="FEEVAETQPNAIAVSCGDEKVTYAKLNKQANQVARLIKQQGVTAD TCVGLLTNRSVEMMVGLLAILKAGAAFVPIDPHYPEERISYVLENSMARLVLTHDSLAE KQWGSVVRLDVNDSRLEMEDNSNLPSQASPGDLAYVIYTSGSTGKPKGVMVEHGNLMNF CSGIGKHIDFASADKMLAVTTISFDIFLLETIVPLTKGMTVVIATEQQQADPQVLKELI LQEEITFLQLTPSRLQLMLEEKSNLHALDCLKAILIGGEALSASLFQRLRTKTKARLYN LYGPTETTIWSTVQDLTDAEEVTIGAPLPNTQVYILDEHLQLQPIKITGDLYIAGDGVT RGYFDQPTLTAERYIPNPFQPGQRMYKTGDLARWLPDGRIEYVGRSDFQCKVR" CDS_motif complement(26010..26096) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0013" /evalue="4.00E-11" /label="NRPS-A_a6" /locus_tag="BP422_RS11430" /protein_end="2447" /protein_start="2418" /score="35.2" /tool="antismash" /translation="PIKITGDLYIAGDGVTRGYFDQPTLTAER" CDS_motif complement(26598..26657) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0012" /evalue="1.90E-11" /label="NRPS-A_a3" /locus_tag="BP422_RS11430" /protein_end="2251" /protein_start="2231" /score="35.5" /tool="antismash" /translation="AYVIYTSGSTGKPKGVMVEH" CDS_motif complement(26841..26882) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0011" /evalue="1.80E-05" /label="NRPS-A_a2" /locus_tag="BP422_RS11430" /protein_end="2170" /protein_start="2156" /score="17.9" /tool="antismash" /translation="LAILKAGAAFVPID" CDS_motif complement(27411..27530) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0010" /evalue="1.40E-16" /label="C67_LCL_14fromHMM" /locus_tag="BP422_RS11430" /protein_end="1980" /protein_start="1940" /score="52.8" /tool="antismash" /translation="KERALAALSHADYPFEMLVDRLMLPKDTARNPLFDVMFIL" aSDomain complement(27576..28430) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="3.80E-106" /label="BP422_RS11430_Condensation_LCL.1" /locus_tag="BP422_RS11430" /protein_end="1925" /protein_start="1640" /score="346.4" /specificity="C activity: active" /specificity="Active site motif: HHIVSDG" /tool="antismash" /translation="DAYPATSSQQRIYVLEQMQEGAVAYNIPTVMMLEGELDREAFERA FVSLVQRHESLRTSFSIVDGALMQTVQPSVDFTLAYSEVDENEAKRTVEQFIQPFDLSK APLVRGMLIRIDVNKHLLLFDMHHIVSDGVSINILIREFFQLYQGLKLPELRIQYKDYS VWQTEQLANGVLAAQEKFWQGELDGELPVLNLPTDHPRPSVQSFEGDVLTFEISQEMTE KILALAKNNGATLYMTLLGALTIMLSKYAGEEDIIIGSPVAGRHHADLENIVGVFLNTL AMRN" CDS_motif complement(27579..27668) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0009" /evalue="9.50E-14" /label="C5_LCL_267-296" /locus_tag="BP422_RS11430" /protein_end="1924" /protein_start="1894" /score="43.7" /tool="antismash" /translation="DIIIGSPVAGRHHADLENIVGVFLNTLAMR" CDS_motif complement(27921..27959) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0008" /evalue="2.50E-04" /label="C4_LCL_164-176" /locus_tag="BP422_RS11430" /protein_end="1810" /protein_start="1797" /score="13.7" /tool="antismash" /translation="QYKDYSVWQTEQL" CDS_motif complement(27990..28055) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0007" /evalue="2.50E-10" /label="C3_LCL_132-143" /locus_tag="BP422_RS11430" /protein_end="1787" /protein_start="1765" /score="32.8" /tool="antismash" /translation="MHHIVSDGVSINILIREFFQLY" CDS_motif complement(28251..28361) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0006" /evalue="3.10E-18" /label="C2_LCL_024-062" /locus_tag="BP422_RS11430" /protein_end="1700" /protein_start="1663" /score="58.2" /tool="antismash" /translation="AYNIPTVMMLEGELDREAFERAFVSLVQRHESLRTSF" aSDomain complement(28482..28676) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_PCP.1" /evalue="3.10E-22" /label="BP422_RS11430_PCP.1" /locus_tag="BP422_RS11430" /protein_end="1623" /protein_start="1558" /score="70.5" /tool="antismash" /translation="LALGQIWSDVLGYTELSIDDDFFRLGGDSLLAIGIVSRVTKQLQK EMTITDLFQTPTIRQLAMLM" aSModule complement(28482..33233) /complete /domains="nrpspksdomains_BP422_RS11430_PKS_KS.1" /domains="nrpspksdomains_BP422_RS11430_PKS_DHt.1" /domains="nrpspksdomains_BP422_RS11430_cMT.1" /domains="nrpspksdomains_BP422_RS11430_PKS_KR.1" /domains="nrpspksdomains_BP422_RS11430_PCP.1" /locus_tags="BP422_RS11430" /monomer_pairings="mal -> Me-ccmal" /tool="antismash" /type="pks" aSDomain complement(28962..29543) /ASF="KR domain putatively catalyzing L-configuration product formation" /ASF="catalytic triad S,Y,N found: True" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_PKS_KR.1" /evalue="7.30E-47" /label="BP422_RS11430_PKS_KR.1" /locus_tag="BP422_RS11430" /protein_end="1463" /protein_start="1269" /score="151.6" /specificity="KR activity: active" /specificity="KR stereochemistry: (unknown)" /tool="antismash" /translation="GVYLIAGGTGKLGLAFSKHLAAQKNVTLVLINRSPLPPNHEWQER LQHPDCSSAEARKLKALLELEEMGAQVACYAADVSNRQQMEDISKQVRARYGPINGIIQ SAAHITFETIQTKTFTHFQNGLKAKMAGTVILDQIAEPEHLDFFVIFSSLASIWGGATG SDYVSSNCFLDAYSAARSRTGKPTIALNWYA" CDS_motif complement(29004..29111) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0005" /evalue="5.40E-12" /label="PKSI-KR_m4" /locus_tag="BP422_RS11430" /protein_end="1449" /protein_start="1413" /score="38.2" /tool="antismash" /translation="LDFFVIFSSLASIWGGATGSDYVSSNCFLDAYSAAR" CDS_motif complement(29442..29540) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0004" /evalue="5.40E-10" /label="PKSI-KR_m1" /locus_tag="BP422_RS11430" /protein_end="1303" /protein_start="1270" /score="31.9" /tool="antismash" /translation="VYLIAGGTGKLGLAFSKHLAAQKNVTLVLINRS" CDS_motif complement(29610..29648) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0003" /evalue="1.40E+01" /label="NRPS-A_a8" /locus_tag="BP422_RS11430" /protein_end="1247" /protein_start="1234" /score="-0.9" /tool="antismash" /translation="RDDTLVAYRGNRI" aSDomain complement(30381..30869) /aSDomain="MT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_cMT.1" /domain_subtypes="cMT" /evalue="2.70E-36" /label="BP422_RS11430_cMT.1" /locus_tag="BP422_RS11430" /protein_end="990" /protein_start="827" /score="116.3" /tool="antismash" /translation="QYIHSFSRPVRILELGGGSSSLTRLLLPKIAKQDVSYLFTDGAQS SLVEAEKQFQEVYPFVQFRPFNMELAPAEQGFDLHAYDVIIANNAIHRSKDVRASLSIL HQLLAEQGVLFAIELVKNRSTANVIGGLAADWWQHEDTDLRPQTRLMDALRWEKALRDT " aSDomain complement(31458..31853) /aSDomain="PKS_DHt" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_PKS_DHt.1" /evalue="2.00E-10" /label="BP422_RS11430_PKS_DHt.1" /locus_tag="BP422_RS11430" /protein_end="631" /protein_start="499" /score="32.9" /tool="antismash" /translation="PSEHSLLDMCATANIGRGHYRYRLAFIINNKEDFLQQINRLCVGE RTQDGAPLVDENRVFYGELNSRGESSLPISVQMDSSDPVEMAKQYVTGVPINWLEYYRP VKWKKVPLPTYSFAKTRHWVQSDQPAND" aSDomain complement(31971..33233) /ASF="found active site cysteine: True, scaffold matched GSSS: True" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11430_PKS_KS.1" /domain_subtypes="Trans-AT-KS" /evalue="1.20E-155" /label="BP422_RS11430_PKS_KS.1" /locus_tag="BP422_RS11430" /protein_end="460" /protein_start="39" /score="510.6" /specificity="transATor: (unknown)" /tool="antismash" /translation="IAIIGMACRFPGANSLEEYWNNLKQGHDSIGDIPAARRPDVERVA REFFNGKDFKYERMGYLDHVDLFDHAFFEISPAEARTMDPYQRMFLELAWETFEHAGYS EKMISGSPTGVFLGYCDNESQYQRVLKNVDSSSLAGNVAAIIASRISYLLNLSGPSQLI NTSCSSSLVALHQACQAIGNNDCRMALVGGVNLSLFPIQQDTDFGIVSVERKTKAFDDF ADGTVWGEGLGAVLLKSYEQAVKDNDYIHAVIKSTAVNCDGRSTSITAPNAISQSALLR TTWERARINPESISYIEAHGTGTRLGDPVEIEGIMHAFQKVSKRKQFCAIGSVKSNIGH TIAASGVAGIIKTVLMMKHRQIPPTLHVKRPNTLIPFIDSPVYINDVLKAWDVEADQPV RRAGVSAFGLSGTNAHVILEEP" CDS_motif complement(32301..32348) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0002" /evalue="3.50E-04" /label="PKSI-KS_m5" /locus_tag="BP422_RS11430" /protein_end="350" /protein_start="334" /score="12.8" /tool="antismash" /translation="YIEAHGTGTRLGDPVE" CDS_motif complement(32715..32762) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11430_0001" /evalue="3.30E-04" /label="PKSI-KS_m3" /locus_tag="BP422_RS11430" /protein_end="212" /protein_start="196" /score="13.2" /tool="antismash" /translation="GPSQLINTSCSSSLVA" misc_feature 33331..33340 /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: strong, score: 18.04" /tool="antismash" gene complement(33352..36042) /gene="edeJ" /locus_tag="BP422_RS11435" /old_locus_tag="BP422_11115" CDS complement(33352..36042) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (276-677). E-value: 5.9e-103. Score: 336.5. Matches aSDomain: nrpspksdomains_BP422_RS11435_AMP-binding.1" /NRPS_PKS="Domain: PCP (782-851). E-value: 1.6e-21. Score: 68.3. Matches aSDomain: nrpspksdomains_BP422_RS11435_PCP.1" /codon_start=1 /gene="edeJ" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127: condensation domain-containing protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249069.1" /locus_tag="BP422_RS11435" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11115" /product="edeine non-ribosomal peptide synthetase EdeJ" /protein_id="WP_088907833.1" /sec_met_domain="Condensation (E-value: 5.3e-10, bitscore: 37.3, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 7.3e-112, bitscore: 372.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 9.8e-11, bitscore: 40.5, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="METTISQNILLTSRKFSREEQYWQEKLQGEWTLSLLPTEGTEKEG DGEEETKEISFVLPDDLNAAVTAHCDHHPMKLYLFLLSTYQIMLNRYKQTDDMIILTPV FQNPLPPNAWNRVLPLRVRMHQEATFADVAKEGKQLVKEAMEHQNYPFSQMMQWLDLSD TDLKTLLDTAFVLENMQDIAALEGLSLQVVFAFKQTEDGITGRVRYAGEQFQEAVIERM ISHYQQILREVVVDPKRLVHTIDMLTEAERTDLLYTRNQTDVPHSAPKPIHQLIEEQAA RTPHLTAAVFGNNTLTYGQLNGKANCLAHMLKESGIGRGSYVPVLMNRSLNLVISLLAV MKTGAAFVPLDVQSPTERKKQLLDELDCPVTLIGPEIRQEPSFVQLTRAVIVDADDIRE EGDLNVQVNVDDPIYVIYTSGSTGKPKGAVVPHIGIFNRFRWMDEHYGCTEQDAIFQTT PHHYDSSVWQLFWPLLHGGRTVLPIPEFEMTLDQVLHAISTYQITITDFVPSVFNLLVD QMETRMDIHDSLSAIRHLILGGEEITAHTVHLFLQRFPHVRITNLYGPTETSIGVIYFE IDHTHEGQIPIGKPIANTKILLLDSNRKLVPVGHQGEIYITGLCLGHGYLHDPEKTAAS FVDNPYPEIGYQKLYRTGDLGRYLPNGNIKFCDRIDHQVKVRGHRIELGEIDEVLLSHP LVKECAVLFQEEKARLCAYYVSNAQELTASDLRGYLSERLPDHMIPSFFVSIEKMPLTA GGKINRKLLPKVDEQQASDAEYVAPRNEKEEQLVTIWKEILGIEKVGVHDSFFQLGGNS LLLLKMHAQIVKQVDSEISVAHLFSYYTIAMFVDFLEQRKQDQFASMEEQSDDDESLLE LLREVKEGVLSVDKGAELIDKRKGK" aSDomain complement(33490..33696) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11435_PCP.1" /evalue="1.60E-21" /label="BP422_RS11435_PCP.1" /locus_tag="BP422_RS11435" /protein_end="851" /protein_start="782" /score="68.3" /tool="antismash" /translation="EEQLVTIWKEILGIEKVGVHDSFFQLGGNSLLLLKMHAQIVKQVD SEISVAHLFSYYTIAMFVDFLEQR" aSModule complement(33490..37396) /complete /domains="nrpspksdomains_BP422_RS11440_Condensation_LCL.1" /domains="nrpspksdomains_BP422_RS11435_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11435_PCP.1" /locus_tags="BP422_RS11435" /locus_tags="BP422_RS11440" /monomer_pairings="X -> X" /monomer_pairings="X -> X" /tool="antismash" /type="nrps" CDS_motif complement(33985..34047) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11435_0005" /evalue="3.50E-10" /label="NRPS-A_a8" /locus_tag="BP422_RS11435" /protein_end="686" /protein_start="665" /score="32.0" /tool="antismash" /translation="FCDRIDHQVKVRGHRIELGEI" aSDomain complement(34012..35214) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11435_AMP-binding.1" /evalue="5.90E-103" /label="BP422_RS11435_AMP-binding.1" /locus_tag="BP422_RS11435" /protein_end="677" /protein_start="276" /score="336.5" /specificity="substrate consensus: X" /tool="antismash" /translation="EEQAARTPHLTAAVFGNNTLTYGQLNGKANCLAHMLKESGIGRGS YVPVLMNRSLNLVISLLAVMKTGAAFVPLDVQSPTERKKQLLDELDCPVTLIGPEIRQE PSFVQLTRAVIVDADDIREEGDLNVQVNVDDPIYVIYTSGSTGKPKGAVVPHIGIFNRF RWMDEHYGCTEQDAIFQTTPHHYDSSVWQLFWPLLHGGRTVLPIPEFEMTLDQVLHAIS TYQITITDFVPSVFNLLVDQMETRMDIHDSLSAIRHLILGGEEITAHTVHLFLQRFPHV RITNLYGPTETSIGVIYFEIDHTHEGQIPIGKPIANTKILLLDSNRKLVPVGHQGEIYI TGLCLGHGYLHDPEKTAASFVDNPYPEIGYQKLYRTGDLGRYLPNGNIKFCDRIDHQVK VR" CDS_motif complement(34135..34224) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11435_0004" /evalue="8.00E-12" /label="NRPS-A_a6" /locus_tag="BP422_RS11435" /protein_end="636" /protein_start="606" /score="37.4" /tool="antismash" /translation="PVGHQGEIYITGLCLGHGYLHDPEKTAASF" CDS_motif complement(34747..34803) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11435_0003" /evalue="2.00E-09" /label="NRPS-A_a3" /locus_tag="BP422_RS11435" /protein_end="432" /protein_start="413" /score="29.5" /tool="antismash" /translation="YVIYTSGSTGKPKGAVVPH" CDS_motif complement(34990..35031) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11435_0002" /evalue="1.80E-05" /label="NRPS-A_a2" /locus_tag="BP422_RS11435" /protein_end="351" /protein_start="337" /score="17.9" /tool="antismash" /translation="LAVMKTGAAFVPLD" CDS_motif complement(35248..35280) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11435_0001" /evalue="9.90E+01" /label="NRPS-A_a3" /locus_tag="BP422_RS11435" /protein_end="265" /protein_start="254" /score="-3.4" /tool="antismash" /translation="LLYTRNQTDVP" gene complement(36074..40057) /gene="edeK" /locus_tag="BP422_RS11440" /old_locus_tag="BP422_11120" CDS complement(36074..40057) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (275-693). E-value: 1.7e-107. Score: 351.5. Matches aSDomain: nrpspksdomains_BP422_RS11440_AMP-binding.1" /NRPS_PKS="Domain: PCP (801-871). E-value: 7.4e-20. Score: 62.9. Matches aSDomain: nrpspksdomains_BP422_RS11440_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (887-1169). E-value: 1.4e-92. Score: 301.9. Matches aSDomain: nrpspksdomains_BP422_RS11440_Condensation_LCL.1" /codon_start=1 /gene="edeK" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_087349102.1" /locus_tag="BP422_RS11440" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11120" /product="edeine non-ribosomal peptide synthetase EdeK" /protein_id="WP_088907834.1" /sec_met_domain="AMP-binding (E-value: 1.5e-120, bitscore: 401.0, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1.2e-15, bitscore: 56.2, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 6.9e-79, bitscore: 263.5, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MTTITAQNILLASGQFDREKGYWMENLSREFHSLDLPTDSRASFQ RQSELRELTIMFPDELSKALIHLSNGSDQRLFMALLSGFGILLSKYTGHQDICVGTAIF RQTTPGEFLNKVLPLRHQVLPEWSIKELLQEVRQTLKAAVEHQNYPILRLIEELQVPQQ GNSTPFFEATCLLDVLHDQDSLEQVSSELQLLFSKKGNFLELLVRYVGQRYQLPMMERM MEHLVRIYQVIVTQPNQKIAEIACLSTEEVRELVLSFNDNRVAFPRDQSFDRLFEEQVK KTPHRKAVTDGKSTLTYQELNERSNRLARHFIQQGLRPGTKIGIYMKRNVDTLVAILAV FKAGGAYVPIDPDYPLHRILYIVQKSEIAGLITQPDLLDGLESIQASSPELKYLYVFGQ SDESVESLSGEDIDRESAGTDLAYIIFTSGTTGQPKGVMVHHRGMINHIFAKINDLSLC EDDLVAQTASLCFDISVWQYLAVLLVGGSVLVVDTETVMDTQALHNVLRSNRVTVAEVV PSLLSVLLDLVQEWPDSARSFPDLRWMAVTGEELPAPLVRRWFACYTEIPLVNMYGPTE ASDDITHHIIRGMPSDQQIVVPIGIPIQNTHIYILDQNQCICPRGVKGEICVAGPGVGY GYYKDEERTQKVFVANPYASWVEDPDYQVLYRTGDVGRITEDGYIEYFGRMDNQVKIRG YRIELSEIEQVMRRHPAVKDAVVLALSEETGAKYLCAYVVPLEEFSARDVRDYLFTVLP EYMVPMHYVKQNVLPLTPNGKVDRGALPKPGIQDRVDTSIFVSATTETEKALTQIWGHV LQLDPNTISARDNFFALGGHSLKINTVAAQIAQQFGVQLPLRTMFNHPTIQELGKVIDG ADKTIMKRRFPVEARSYYPVTPAQRKFFILQQVNPADTSLHITAARFIEGALSREKVEQ AFQGLVDRHESLRTSFDYIDGQVVQIVHDSLVFHLEVSEASAEQLEVSLATFVRPFDLR QSPLLRAGLIRIAPEKHLLMFDMHHIVSDGVSMDILIEDFVRVYAGVTLPALEVQQKEF AVWQESALESGELQADYWADLFTSPAPLLSIPTDYERPESLTYPGATIEFDISAEERQR LQELATQEHATLYMVLLSVYNMLLAKYSGQEDVVVGTPVAGRKFAEFDEVIGMFINTIP LRNYPKGEKTYREFLAEVREHTLASFEQADYPIDLFVQTLGLEPNTGRQPLFDTIFVLQ NMDNPEGELELEDMIVKNYPLQNNTAKLDLHLSAYPVFDRLTCKLDYRSDLFRRETMEQ FVSDFKSLLQQLMEDPLRLLQDFELTLEVALIQAQGVDWDFEF" CDS_motif complement(36386..36505) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0011" /evalue="4.30E-07" /label="C67_LCL_14fromHMM" /locus_tag="BP422_RS11440" /protein_end="1224" /protein_start="1184" /score="22.2" /tool="antismash" /translation="REHTLASFEQADYPIDLFVQTLGLEPNTGRQPLFDTIFVL" aSDomain complement(36551..37396) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11440_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="1.40E-92" /label="BP422_RS11440_Condensation_LCL.1" /locus_tag="BP422_RS11440" /protein_end="1169" /protein_start="887" /score="301.9" /specificity="C activity: active" /specificity="Active site motif: HHIVSDG" /tool="antismash" /translation="YYPVTPAQRKFFILQQVNPADTSLHITAARFIEGALSREKVEQAF QGLVDRHESLRTSFDYIDGQVVQIVHDSLVFHLEVSEASAEQLEVSLATFVRPFDLRQS PLLRAGLIRIAPEKHLLMFDMHHIVSDGVSMDILIEDFVRVYAGVTLPALEVQQKEFAV WQESALESGELQADYWADLFTSPAPLLSIPTDYERPESLTYPGATIEFDISAEERQRLQ ELATQEHATLYMVLLSVYNMLLAKYSGQEDVVVGTPVAGRKFAEFDEVIGMFINTIPLR N" CDS_motif complement(36554..36643) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0010" /evalue="2.10E-14" /label="C5_LCL_267-296" /locus_tag="BP422_RS11440" /protein_end="1168" /protein_start="1138" /score="45.8" /tool="antismash" /translation="DVVVGTPVAGRKFAEFDEVIGMFINTIPLR" CDS_motif complement(36959..37024) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0009" /evalue="5.60E-09" /label="C3_LCL_132-143" /locus_tag="BP422_RS11440" /protein_end="1033" /protein_start="1011" /score="28.5" /tool="antismash" /translation="MHHIVSDGVSMDILIEDFVRVY" CDS_motif complement(37220..37324) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0008" /evalue="2.20E-10" /label="C2_LCL_024-062" /locus_tag="BP422_RS11440" /protein_end="946" /protein_start="911" /score="32.9" /tool="antismash" /translation="HITAARFIEGALSREKVEQAFQGLVDRHESLRTSF" aSDomain complement(37445..37654) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11440_PCP.1" /evalue="7.40E-20" /label="BP422_RS11440_PCP.1" /locus_tag="BP422_RS11440" /protein_end="871" /protein_start="801" /score="62.9" /tool="antismash" /translation="EKALTQIWGHVLQLDPNTISARDNFFALGGHSLKINTVAAQIAQQ FGVQLPLRTMFNHPTIQELGKVIDG" aSModule complement(37445..41422) /complete /domains="nrpspksdomains_BP422_RS11445_Condensation_LCL.1" /domains="nrpspksdomains_BP422_RS11440_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11440_PCP.1" /locus_tags="BP422_RS11440" /locus_tags="BP422_RS11445" /monomer_pairings="X -> X" /monomer_pairings="X -> X" /tool="antismash" /type="nrps" CDS_motif complement(37949..38014) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0007" /evalue="2.30E-11" /label="NRPS-A_a8" /locus_tag="BP422_RS11440" /protein_end="703" /protein_start="681" /score="35.6" /tool="antismash" /translation="YFGRMDNQVKIRGYRIELSEIE" aSDomain complement(37979..39232) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11440_AMP-binding.1" /evalue="1.70E-107" /label="BP422_RS11440_AMP-binding.1" /locus_tag="BP422_RS11440" /protein_end="693" /protein_start="275" /score="351.5" /specificity="substrate consensus: X" /tool="antismash" /translation="FEEQVKKTPHRKAVTDGKSTLTYQELNERSNRLARHFIQQGLRPG TKIGIYMKRNVDTLVAILAVFKAGGAYVPIDPDYPLHRILYIVQKSEIAGLITQPDLLD GLESIQASSPELKYLYVFGQSDESVESLSGEDIDRESAGTDLAYIIFTSGTTGQPKGVM VHHRGMINHIFAKINDLSLCEDDLVAQTASLCFDISVWQYLAVLLVGGSVLVVDTETVM DTQALHNVLRSNRVTVAEVVPSLLSVLLDLVQEWPDSARSFPDLRWMAVTGEELPAPLV RRWFACYTEIPLVNMYGPTEASDDITHHIIRGMPSDQQIVVPIGIPIQNTHIYILDQNQ CICPRGVKGEICVAGPGVGYGYYKDEERTQKVFVANPYASWVEDPDYQVLYRTGDVGRI TEDGYIEYFGRMDNQVKIR" CDS_motif complement(38114..38203) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0006" /evalue="4.10E-10" /label="NRPS-A_a6" /locus_tag="BP422_RS11440" /protein_end="648" /protein_start="618" /score="31.9" /tool="antismash" /translation="PRGVKGEICVAGPGVGYGYYKDEERTQKVF" CDS_motif complement(38582..38623) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0005" /evalue="2.70E+01" /label="NRPS-A_a2" /locus_tag="BP422_RS11440" /protein_end="492" /protein_start="478" /score="-0.7" /tool="antismash" /translation="LAVLLVGGSVLVVD" CDS_motif complement(38735..38794) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0004" /evalue="3.00E-10" /label="NRPS-A_a3" /locus_tag="BP422_RS11440" /protein_end="441" /protein_start="421" /score="32.0" /tool="antismash" /translation="AYIIFTSGTTGQPKGVMVHH" CDS_motif complement(39005..39046) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0003" /evalue="9.70E-06" /label="NRPS-A_a2" /locus_tag="BP422_RS11440" /protein_end="351" /protein_start="337" /score="18.7" /tool="antismash" /translation="LAVFKAGGAYVPID" CDS_motif complement(39473..39508) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0002" /evalue="3.20E+01" /label="C3_dual_135-156" /locus_tag="BP422_RS11440" /protein_end="195" /protein_start="183" /score="-2.0" /tool="antismash" /translation="SLEQVSSELQLL" CDS_motif complement(39548..39649) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11440_0001" /evalue="1.20E-06" /label="C67_LCL_14fromHMM" /locus_tag="BP422_RS11440" /protein_end="170" /protein_start="136" /score="20.8" /tool="antismash" /translation="RQTLKAAVEHQNYPILRLIEELQVPQQGNSTPFF" gene complement(40091..43381) /gene="edeL" /locus_tag="BP422_RS11445" /old_locus_tag="BP422_11125" CDS complement(40091..43381) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (44-463). E-value: 4.9e-110. Score: 359.9. Matches aSDomain: nrpspksdomains_BP422_RS11445_AMP-binding.1" /NRPS_PKS="Domain: PCP (569-636). E-value: 4.3e-24. Score: 76.5. Matches aSDomain: nrpspksdomains_BP422_RS11445_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (653-938). E-value: 4.9e-93. Score: 303.3. Matches aSDomain: nrpspksdomains_BP422_RS11445_Condensation_LCL.1" /codon_start=1 /gene="edeL" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_087349101.1" /locus_tag="BP422_RS11445" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11125" /product="edeine non-ribosomal peptide synthetase EdeL" /protein_id="WP_088907835.1" /sec_met_domain="AMP-binding (E-value: 3.2e-119, bitscore: 396.7, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1e-12, bitscore: 46.8, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 3.3e-76, bitscore: 254.7, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MNGRMELDLDLNEFNLLTDDEANLLSRVNQTDKPYRNKVTIAELF ARQAEKTPDRVAVVEADRERTYAELHAEANQLARILKDAGVVPSQLVGILADRSSRMVA AVLAILQAGGGYVPVDPHYPRARIRYLLQDSRCKVLVTESIYLDEIIPDLPDSIETIIC LDETSFHHEGYKVYTASDIRRQKDEILAPAGSEVDVAYVIYTSGSTGAPKGVMITHKQV LNTLFWLEETFPLSETDVVAQKTSISFTDSVWELFWPLMVGSKLSILKEEDGKDPGALY DWLREQRITVTQFVPTMMNVFLAHVHSRNETDPLPNLKWVFNGGEALTANLVREWNRLF RVARIANIYGMTESAIYASVYLCTEQPAEETLRIPIGVPIANTHMYILGQTGEICPPDV KGEICIGGIGITDGYLGKPELTEKAFTYHPITGERLYRTGDVGLISETGVFEYLGRMDD QVQVRGYRVELKEVERAVLQHPAVNQVAVLAMTDQMGLIELACYYVVQKDGVQPDGLRA HLLEWLPEYMIPSYFMDLSEMPLTPHGKIDRKALPAVKPSVSSEYVSPENPIEQKLAEL WADVLQIPSPGVLDHFVGHGGHSLKAIQLLSRVESDFQVKLSMRDLFDAPTIRGLANRI TGSLQEMEQKPIALLSDQEYYPVTRAQERLYLLWQLEEDATSYHTPGVMRITGSLDSGR LQDVADQLVARHEALRTSFHLMEGQVKQKVHSDLSVLIETWKTDEEAVEKTIERFFRSF DLKQAPLLRIGLIELSSEDHLLIFDMHHIISDGISKSILLEEFCYLYQGQVLPELSVQA KEFAWWQREQAAEIGWAEHEAYWLDAFSGQPQPLAIPTDYPRPQTMTFDGDELLTELSG EWLEKLDSFTRQSSTTLYMLLLAAYSVLLSRYSNQEDIVVGCDMDGRQRAEFAPVVGMF VNTLALRNWPKKELTVQEYIGQVRQNVLSGFEHGDYPFDQLVSQIQFPRDPARNPLFDA MLTLHHAAEQQKVRLDQIEFAPYEFRRKAAMLDLALEVVKAEDHIGMHWQYNTNLYHRR TIERMAQDFVILLEQMVAHPNRTIGQLQIGHGVVQVAQGQVDDDDFAF" CDS_motif complement(40403..40522) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0008" /evalue="9.10E-16" /label="C67_LCL_14fromHMM" /locus_tag="BP422_RS11445" /protein_end="993" /protein_start="953" /score="50.2" /tool="antismash" /translation="RQNVLSGFEHGDYPFDQLVSQIQFPRDPARNPLFDAMLTL" aSDomain complement(40568..41422) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11445_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="4.90E-93" /label="BP422_RS11445_Condensation_LCL.1" /locus_tag="BP422_RS11445" /protein_end="938" /protein_start="653" /score="303.3" /specificity="C activity: active" /specificity="Active site motif: HHIISDG" /tool="antismash" /translation="EYYPVTRAQERLYLLWQLEEDATSYHTPGVMRITGSLDSGRLQDV ADQLVARHEALRTSFHLMEGQVKQKVHSDLSVLIETWKTDEEAVEKTIERFFRSFDLKQ APLLRIGLIELSSEDHLLIFDMHHIISDGISKSILLEEFCYLYQGQVLPELSVQAKEFA WWQREQAAEIGWAEHEAYWLDAFSGQPQPLAIPTDYPRPQTMTFDGDELLTELSGEWLE KLDSFTRQSSTTLYMLLLAAYSVLLSRYSNQEDIVVGCDMDGRQRAEFAPVVGMFVNTL ALRN" CDS_motif complement(40571..40660) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0007" /evalue="4.40E-12" /label="C5_LCL_267-296" /locus_tag="BP422_RS11445" /protein_end="937" /protein_start="907" /score="38.4" /tool="antismash" /translation="DIVVGCDMDGRQRAEFAPVVGMFVNTLALR" CDS_motif complement(40982..41047) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0006" /evalue="4.30E-07" /label="C3_LCL_132-143" /locus_tag="BP422_RS11445" /protein_end="800" /protein_start="778" /score="22.5" /tool="antismash" /translation="MHHIISDGISKSILLEEFCYLY" CDS_motif complement(41240..41356) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0005" /evalue="5.90E-15" /label="C2_LCL_024-062" /locus_tag="BP422_RS11445" /protein_end="714" /protein_start="675" /score="47.6" /tool="antismash" /translation="TSYHTPGVMRITGSLDSGRLQDVADQLVARHEALRTSFH" aSDomain complement(41474..41674) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11445_PCP.1" /evalue="4.30E-24" /label="BP422_RS11445_PCP.1" /locus_tag="BP422_RS11445" /protein_end="636" /protein_start="569" /score="76.5" /tool="antismash" /translation="EQKLAELWADVLQIPSPGVLDHFVGHGGHSLKAIQLLSRVESDFQ VKLSMRDLFDAPTIRGLANRIT" aSModule complement(41474..43249) /complete /domains="nrpspksdomains_BP422_RS11445_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11445_PCP.1" /locus_tags="BP422_RS11445" /monomer_pairings="X -> X" /starter_module /tool="antismash" /type="nrps" CDS_motif complement(41963..42028) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0004" /evalue="1.10E-10" /label="NRPS-A_a8" /locus_tag="BP422_RS11445" /protein_end="473" /protein_start="451" /score="33.5" /tool="antismash" /translation="YLGRMDDQVQVRGYRVELKEVE" aSDomain complement(41993..43249) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11445_AMP-binding.1" /evalue="4.90E-110" /label="BP422_RS11445_AMP-binding.1" /locus_tag="BP422_RS11445" /protein_end="463" /protein_start="44" /score="359.9" /specificity="substrate consensus: X" /tool="antismash" /translation="FARQAEKTPDRVAVVEADRERTYAELHAEANQLARILKDAGVVPS QLVGILADRSSRMVAAVLAILQAGGGYVPVDPHYPRARIRYLLQDSRCKVLVTESIYLD EIIPDLPDSIETIICLDETSFHHEGYKVYTASDIRRQKDEILAPAGSEVDVAYVIYTSG STGAPKGVMITHKQVLNTLFWLEETFPLSETDVVAQKTSISFTDSVWELFWPLMVGSKL SILKEEDGKDPGALYDWLREQRITVTQFVPTMMNVFLAHVHSRNETDPLPNLKWVFNGG EALTANLVREWNRLFRVARIANIYGMTESAIYASVYLCTEQPAEETLRIPIGVPIANTH MYILGQTGEICPPDVKGEICIGGIGITDGYLGKPELTEKAFTYHPITGERLYRTGDVGL ISETGVFEYLGRMDDQVQVR" CDS_motif complement(42107..42196) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0003" /evalue="3.50E-11" /label="NRPS-A_a6" /locus_tag="BP422_RS11445" /protein_end="425" /protein_start="395" /score="35.3" /tool="antismash" /translation="PPDVKGEICIGGIGITDGYLGKPELTEKAF" CDS_motif complement(42725..42784) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0002" /evalue="5.40E-11" /label="NRPS-A_a3" /locus_tag="BP422_RS11445" /protein_end="219" /protein_start="199" /score="34.2" /tool="antismash" /translation="AYVIYTSGSTGAPKGVMITH" CDS_motif complement(43022..43063) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11445_0001" /evalue="4.30E-04" /label="NRPS-A_a2" /locus_tag="BP422_RS11445" /protein_end="120" /protein_start="106" /score="13.7" /tool="antismash" /translation="LAILQAGGGYVPVD" gene complement(43399..44562) /locus_tag="BP422_RS11450" /old_locus_tag="BP422_11130" CDS complement(43399..44562) /GO_function="GO:0030170 - pyridoxal phosphate binding [Evidence IEA]" /GO_process="GO:0009058 - biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_1_2 (43-381). E-value: 2.1e-48. Score: 157.2. Matches aSDomain: nrpspksdomains_BP422_RS11450_Aminotran_1_2.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (rule-based-clusters) DegT_DnrJ_EryC1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019: aminotransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727239.1" /locus_tag="BP422_RS11450" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11130" /product="aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme" /protein_id="WP_088907836.1" /sec_met_domain="Aminotran_1_2 (E-value: 1.7e-46, bitscore: 157.5, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.5e-06, bitscore: 26.2, seeds: 38, tool: rule-based-clusters)" /transl_table=11 /translation="MEIRSSINFHDERFLMFVLDQMANELERNGGEAIRMTLGKSEMPL HPEIINSMQQALNSFEKYSLVYPGGLPELKEKLATHYKTKYDVSIKPENFVISVGTSTL FRNLFYLLLKEGDEVLLPLPYYSLYHFCALLVGAKVRYYKIDLDTLRLDVESFKENFTD KTKVVVINTPGNPLGNILTKEELYTIDSIVDGRAAIINDEIYANTYFDDECESVMQLKN TKSTFITTDAFSKAYRMYSRRVGYAIVPDELVQPLTVIQHHTLLTADPVVQFGAMTALD YQHEVDHLVQLYKGRRDYTIDAFQNVPDVRALPARGSFYFTIDCEAFMKRKGISTSLEL ATQIFEATHVATVPGSDFGISNTLRLSYSAAKYNEGINRLREFFTTT" aSDomain complement(43420..44433) /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11450_Aminotran_1_2.1" /evalue="2.10E-48" /label="BP422_RS11450_Aminotran_1_2.1" /locus_tag="BP422_RS11450" /protein_end="381" /protein_start="43" /score="157.2" /tool="antismash" /translation="PLHPEIINSMQQALNSFEKYSLVYPGGLPELKEKLATHYKTKYDV SIKPENFVISVGTSTLFRNLFYLLLKEGDEVLLPLPYYSLYHFCALLVGAKVRYYKIDL DTLRLDVESFKENFTDKTKVVVINTPGNPLGNILTKEELYTIDSIVDGRAAIINDEIYA NTYFDDECESVMQLKNTKSTFITTDAFSKAYRMYSRRVGYAIVPDELVQPLTVIQHHTL LTADPVVQFGAMTALDYQHEVDHLVQLYKGRRDYTIDAFQNVPDVRALPARGSFYFTID CEAFMKRKGISTSLELATQIFEATHVATVPGSDFGISNTLRLSYSAAKYNEGINRLR" gene complement(44578..51093) /gene="edeN" /locus_tag="BP422_RS11455" /old_locus_tag="BP422_11135" CDS complement(44578..51093) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: NRPS-COM_Nterm (0-24). E-value: 9.8e-10. Score: 29.5. Matches aSDomain: nrpspksdomains_BP422_RS11455_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (10-306). E-value: 1.7e-90. Score: 295.1. Matches aSDomain: nrpspksdomains_BP422_RS11455_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (470-865). E-value: 1.4e-100. Score: 328.7. Matches aSDomain: nrpspksdomains_BP422_RS11455_AMP-binding.1" /NRPS_PKS="Domain: PCP (972-1040). E-value: 2.5e-26. Score: 83.6. Matches aSDomain: nrpspksdomains_BP422_RS11455_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (1055-1342). E-value: 1.9e-89. Score: 291.5. Matches aSDomain: nrpspksdomains_BP422_RS11455_Condensation_LCL.1" /NRPS_PKS="Domain: Condensation_LCL (1776-2049). E-value: 1.6e-24. Score: 78.4. Matches aSDomain: nrpspksdomains_BP422_RS11455_Condensation_LCL.2" /codon_start=1 /gene="edeN" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_121602055.1" /locus_tag="BP422_RS11455" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11135" /product="edeine non-ribosomal peptide synthetase EdeN" /protein_id="WP_088907837.1" /sec_met_domain="AMP-binding (E-value: 1.9e-106, bitscore: 354.5, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 2e-15, bitscore: 55.5, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 9.7e-79, bitscore: 263.0, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MNKIDKNNIADILPLSPTQEGMLFYYRLQKDSNLYFEQHRLTLRG KFQLELFTQAVSMAIEANEMLRTVFRWEGLQAPVQLILKQKTLEIPYFDWSELPSGARE RKLSALLSQDKQTPFTLEFGNTIRIQVVRMELYRYEVIWSFHHILMDGWSSGILLREIF TAYGQLCSGLSPAIKQKAKYKEYLRFLKEASKEQSLSYWKDSLQGISSPTPLPYMRDRN EERRFSSYHLRLSRTLTETLEETSKRYRVTISTLLQAAWGILLQKYSDTRDALFEVAYA GRPAHLTGVEEIVGLFIKTYPLRVKRTETTTVKDLLGVMMEEQHQMAPHLYVPSVELKS CSEMDAQTPLAHSLFVFQNYPIDKTLAGLELDFELENITSHETTDYPMVLEVTPGDEWT VHVNYQAWKFQAKDIERLALHYQSLLEQIAADSDQEIRNLTLLSGHERHEMIEEQMKVV PVPSNYCVHELIDQVAEKTPDAVALVQGKQSVTYKELQEQANRLSWALQKEVTDAGRPI VIVCDRSPEMITALLAILKVGCYYVPLDPDLPKARIDQIVNQIEPVLIVTEGSYLELVA DLQTRVFRLDEPACWAQELTQTPQRKASPSNTAYAIFTSGSTGTPKGVRVNHDQLINAL WWHIEFVGFGEQTRTLQIATLTFDASVVEIFCTLISGGTLCLLQRHENKSPQKLAAAIE SQQANVILVVPTMYHALLDHVADGSLDSIQKVLCTGEMLSSSLVERHAALLPQAQMYNL YGPTENSISASGYCVPRQGPFENPLPIGHPSYNVRVFLLDQDFHLLPKGVIGEMYVGGM GVTEGYIADEEKTRASYIMTPYGRLYRTGDLACWTDEGHLQYFGRKDFQIKIRGNRVEL EEIEAVLRRQPGVREAAVVAIQESKRDPYLVACLVAMQPIEEHVLREAVLTYLPDYMLP AFFVHLDALPRTQSGKVDKTALQRMDYTQYRTGKEGAPADELEQQLAQIWRELLAVEKI SMHDHFFSLGGHSLKAAQLVTRLQKERKTDITIRDVFQNPTIRQLADRIRGRQPISYAP IDRVGQAERYRASSSQKRIFVMHGIEGESTSYNMSGVIAVNGHLDVSRVKRVCKEIIQR HEAFRTSFAVQDGEVYQYISDKVPFEIQTIHSDARALDELMEDFRQSFDLTKAPLLQVC LVEVTATQHYLLFNSHHIILDGISLNVLMEDFARLYVGEELPALPIQYKDYADWQWKKR GSEQWNQQEKYWVDTFSDRVPLMSFPLDYLRPSVKTFQGDHYTFFITDSTYGDLHAFAK QNELTVHAVLMSAYYVLLMKYTSQEDFVVGSLVAGRNHPDLERIVGVFINFLPIRNRPR AELVYTDFVQEVQRSLLLAYEHQDYPFEEIVARSAAGIQQMQNPLFDTMLIFHNQREQE VRFTLGDVKFEEVPHESKTSKLDFKLDITPLTDQFRCVLEYDTQLFKAETMEGFADNYL RVLAVLLKHPKQRLDDVDIVHHQTEKEGVMNRLHHAGVAVPELGPAQIMYGTLGFDASD SLHDPEQNVYLSMCMKPGCVPIELIAPVDETSPCVRLLEEKGTGPYHLCYSISNITQFL KRLVDSGFQYDLVSAPKPAVLFNHRLVAFLFLESVGLIELVESEDMKHDEWQSRDQRSA IRLLTPDAEQALSFFTFLGYRVHEKYLDRQSQAIIITLGKADESSIQLVQPRMEHSQEQ RELMKSGCGVYQIEDRVANLTERIDTLIACSIPVSFADRTGRNLQLTDAPYLLLTDGKS AAQRSKPILGEFHTETTPIYSFVQERLLKQEQENGIVAVRCFDIELRSRIELSYMQQAW QALVRRFPLLSPQGLSEPIPLALCDLQEKSEAETAESLRERLIAEQKRPFEDKAGRLVR FELVKLAADRYRLIGSLHSSLSDWRGLGLLLEEWEALYQAIAEGHAPAVDEQPRYEAFA VWQKKMLHYGHFEAQRHEWLTATNPHSAQPFGTGGVATRQVEQYIDPTGHADLLHVAAR SNQELGDILLASYLLLLRQVTQLPSLTLGVVTTNRTQDVLEQMLGNFDNIVPLTIDMQT ISSFSQLLDQTKQVLARMQTLALYPSEHWQATTHMEWPTLFVNQTIPFKAQSAVWKREV KRSFEPEMAGSPLVLQVAETSEGIHVVFTYDPSMLQTAYVESLSDRYVKILKMLAEKSK IK" aSDomain complement(44947..45765) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_Condensation_LCL.2 " /domain_subtypes="Condensation_LCL" /evalue="1.60E-24" /label="BP422_RS11455_Condensation_LCL.2" /locus_tag="BP422_RS11455" /protein_end="2049" /protein_start="1776" /score="78.4" /specificity="C activity: inactive" /specificity="Active site motif: HSSLSDW" /tool="antismash" /translation="SFVQERLLKQEQENGIVAVRCFDIELRSRIELSYMQQAWQALVRR FPLLSPQGLSEPIPLALCDLQEKSEAETAESLRERLIAEQKRPFEDKAGRLVRFELVKL AADRYRLIGSLHSSLSDWRGLGLLLEEWEALYQAIAEGHAPAVDEQPRYEAFAVWQKKM LHYGHFEAQRHEWLTATNPHSAQPFGTGGVATRQVEQYIDPTGHADLLHVAARSNQELG DILLASYLLLLRQVTQLPSLTLGVVTTNRTQDVLEQMLGNFDNIVPLTIDM" CDS_motif complement(44959..45039) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0017" /evalue="1.60E-04" /label="C5_LCL_267-296" /locus_tag="BP422_RS11455" /protein_end="2045" /protein_start="2018" /score="14.2" /tool="antismash" /translation="TLGVVTTNRTQDVLEQMLGNFDNIVPL" CDS_motif complement(45274..45309) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0016" /evalue="1.80E-01" /label="C4_LCL_164-176" /locus_tag="BP422_RS11455" /protein_end="1940" /protein_start="1928" /score="5.0" /tool="antismash" /translation="YEAFAVWQKKML" CDS_motif complement(45358..45396) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0015" /evalue="9.00E+00" /label="C3_LCL_132-143" /locus_tag="BP422_RS11455" /protein_end="1912" /protein_start="1899" /score="-0.6" /tool="antismash" /translation="GLGLLLEEWEALY" CDS_motif complement(45625..45696) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0014" /evalue="1.30E-03" /label="C2_LCL_024-062" /locus_tag="BP422_RS11455" /protein_end="1823" /protein_start="1799" /score="11.2" /tool="antismash" /translation="IELRSRIELSYMQQAWQALVRRFP" CDS_motif complement(46912..47013) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0013" /evalue="1.20E-07" /label="C67_LCL_14fromHMM" /locus_tag="BP422_RS11455" /protein_end="1394" /protein_start="1360" /score="24.0" /tool="antismash" /translation="LAYEHQDYPFEEIVARSAAGIQQMQNPLFDTMLI" aSDomain complement(47068..47928) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="1.90E-89" /label="BP422_RS11455_Condensation_LCL.1" /locus_tag="BP422_RS11455" /protein_end="1342" /protein_start="1055" /score="291.5" /specificity="C activity: active" /specificity="Active site motif: HHIILDG" /tool="antismash" /translation="ERYRASSSQKRIFVMHGIEGESTSYNMSGVIAVNGHLDVSRVKRV CKEIIQRHEAFRTSFAVQDGEVYQYISDKVPFEIQTIHSDARALDELMEDFRQSFDLTK APLLQVCLVEVTATQHYLLFNSHHIILDGISLNVLMEDFARLYVGEELPALPIQYKDYA DWQWKKRGSEQWNQQEKYWVDTFSDRVPLMSFPLDYLRPSVKTFQGDHYTFFITDSTYG DLHAFAKQNELTVHAVLMSAYYVLLMKYTSQEDFVVGSLVAGRNHPDLERIVGVFINFL PIRNRP" CDS_motif complement(47077..47166) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0012" /evalue="7.70E-12" /label="C5_LCL_267-296" /locus_tag="BP422_RS11455" /protein_end="1339" /protein_start="1309" /score="37.6" /tool="antismash" /translation="DFVVGSLVAGRNHPDLERIVGVFINFLPIR" CDS_motif complement(47431..47457) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0011" /evalue="6.00E-02" /label="C4_LCL_164-176" /locus_tag="BP422_RS11455" /protein_end="1221" /protein_start="1212" /score="6.4" /tool="antismash" /translation="QYKDYADWQ" CDS_motif complement(47488..47550) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0010" /evalue="1.20E-08" /label="C3_LCL_132-143" /locus_tag="BP422_RS11455" /protein_end="1202" /protein_start="1181" /score="27.5" /tool="antismash" /translation="HHIILDGISLNVLMEDFARLY" CDS_motif complement(47746..47862) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0009" /evalue="4.80E-13" /label="C2_LCL_024-062" /locus_tag="BP422_RS11455" /protein_end="1116" /protein_start="1077" /score="41.5" /tool="antismash" /translation="TSYNMSGVIAVNGHLDVSRVKRVCKEIIQRHEAFRTSFA" aSDomain complement(47974..48177) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_PCP.1" /evalue="2.50E-26" /label="BP422_RS11455_PCP.1" /locus_tag="BP422_RS11455" /protein_end="1040" /protein_start="972" /score="83.6" /tool="antismash" /translation="EQQLAQIWRELLAVEKISMHDHFFSLGGHSLKAAQLVTRLQKERK TDITIRDVFQNPTIRQLADRIRG" aSModule complement(47974..51063) /complete /domains="nrpspksdomains_BP422_RS11455_Condensation_DCL.1" /domains="nrpspksdomains_BP422_RS11455_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11455_PCP.1" /locus_tags="BP422_RS11455" /monomer_pairings="X -> X" /tool="antismash" /type="nrps" CDS_motif complement(48469..48534) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0008" /evalue="6.00E-10" /label="NRPS-A_a8" /locus_tag="BP422_RS11455" /protein_end="875" /protein_start="853" /score="31.2" /tool="antismash" /translation="YFGRKDFQIKIRGNRVELEEIE" aSDomain complement(48499..49683) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_AMP-binding.1" /evalue="1.40E-100" /label="BP422_RS11455_AMP-binding.1" /locus_tag="BP422_RS11455" /protein_end="865" /protein_start="470" /score="328.7" /specificity="substrate consensus: X" /tool="antismash" /translation="DQVAEKTPDAVALVQGKQSVTYKELQEQANRLSWALQKEVTDAGR PIVIVCDRSPEMITALLAILKVGCYYVPLDPDLPKARIDQIVNQIEPVLIVTEGSYLEL VADLQTRVFRLDEPACWAQELTQTPQRKASPSNTAYAIFTSGSTGTPKGVRVNHDQLIN ALWWHIEFVGFGEQTRTLQIATLTFDASVVEIFCTLISGGTLCLLQRHENKSPQKLAAA IESQQANVILVVPTMYHALLDHVADGSLDSIQKVLCTGEMLSSSLVERHAALLPQAQMY NLYGPTENSISASGYCVPRQGPFENPLPIGHPSYNVRVFLLDQDFHLLPKGVIGEMYVG GMGVTEGYIADEEKTRASYIMTPYGRLYRTGDLACWTDEGHLQYFGRKDFQIKIR" CDS_motif complement(48610..48696) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0007" /evalue="5.80E-09" /label="NRPS-A_a6" /locus_tag="BP422_RS11455" /protein_end="828" /protein_start="799" /score="28.3" /tool="antismash" /translation="PKGVIGEMYVGGMGVTEGYIADEEKTRAS" CDS_motif complement(49210..49269) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0006" /evalue="1.20E-08" /label="NRPS-A_a3" /locus_tag="BP422_RS11455" /protein_end="628" /protein_start="608" /score="27.1" /tool="antismash" /translation="AYAIFTSGSTGTPKGVRVNH" CDS_motif complement(49459..49500) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0005" /evalue="6.90E-04" /label="NRPS-A_a2" /locus_tag="BP422_RS11455" /protein_end="545" /protein_start="531" /score="13.1" /tool="antismash" /translation="LAILKVGCYYVPLD" CDS_motif complement(50011..50127) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0004" /evalue="2.10E-05" /label="C67_DCL_14fromHMM" /locus_tag="BP422_RS11455" /protein_end="361" /protein_start="322" /score="16.8" /tool="antismash" /translation="EQHQMAPHLYVPSVELKSCSEMDAQTPLAHSLFVFQNYP" aSDomain complement(50176..51063) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_Condensation_DCL.1 " /domain_subtypes="Condensation_DCL" /evalue="1.70E-90" /label="BP422_RS11455_Condensation_DCL.1" /locus_tag="BP422_RS11455" /protein_end="306" /protein_start="10" /score="295.1" /specificity="C activity: active" /specificity="Active site motif: HHILMDG" /tool="antismash" /translation="DILPLSPTQEGMLFYYRLQKDSNLYFEQHRLTLRGKFQLELFTQA VSMAIEANEMLRTVFRWEGLQAPVQLILKQKTLEIPYFDWSELPSGARERKLSALLSQD KQTPFTLEFGNTIRIQVVRMELYRYEVIWSFHHILMDGWSSGILLREIFTAYGQLCSGL SPAIKQKAKYKEYLRFLKEASKEQSLSYWKDSLQGISSPTPLPYMRDRNEERRFSSYHL RLSRTLTETLEETSKRYRVTISTLLQAAWGILLQKYSDTRDALFEVAYAGRPAHLTGVE EIVGLFIKTYPLRVK" CDS_motif complement(50182..50256) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0003" /evalue="2.30E-08" /label="C5_DCL_263-294" /locus_tag="BP422_RS11455" /protein_end="304" /protein_start="279" /score="26.5" /tool="antismash" /translation="YAGRPAHLTGVEEIVGLFIKTYPLR" CDS_motif complement(50596..50661) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0002" /evalue="4.70E-12" /label="C3_DCL_135-156" /locus_tag="BP422_RS11455" /protein_end="166" /protein_start="144" /score="38.2" /tool="antismash" /translation="FHHILMDGWSSGILLREIFTAY" CDS_motif complement(50878..50994) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11455_0001" /evalue="5.10E-11" /label="C2_DCL_024-062" /locus_tag="BP422_RS11455" /protein_end="72" /protein_start="33" /score="34.9" /tool="antismash" /translation="LYFEQHRLTLRGKFQLELFTQAVSMAIEANEMLRTVFRW" aSDomain complement(51022..51093) /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11455_NRPS-COM_Nterm.1" /evalue="9.80E-10" /label="BP422_RS11455_NRPS-COM_Nterm.1" /locus_tag="BP422_RS11455" /protein_end="24" /protein_start="0" /score="29.5" /tool="antismash" /translation="MNKIDKNNIADILPLSPTQEGMLF" gene complement(51117..52364) /locus_tag="BP422_RS11460" /old_locus_tag="BP422_11140" CDS complement(51117..52364) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727235.1" /locus_tag="BP422_RS11460" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11140" /product="lysine 2,3-aminomutase" /protein_id="WP_088907838.1" /transl_table=11 /translation="MSVKVLMGKKGFEEFAAIVGFTEAEREERSALLEQSYMPFKVTRY YAELIASQSEPYRTQMINIVLPPPGKKPYKGRFDPYGNKSYRQDETAFLQHKYKKTLLL HIDDFCIANCQFCYKVNEIRHEDIGYTNIMDKAERAVQYLEAHPYIDNVLFTGGDPASF RKTSDLIKLISTLLSVKSIRLVRFATKALAYDPARFLDGELLAFFDQVRQTPGKQVSVI SQFNHPGEISGVSIQATQALLSVGVQIRGQPAIIRGVNDSVETLIDLQRKFLDNRIISY YLTVFMPVRGVEQYAIPLDEAFRNVAESKRNLGGLEKKGVLLTSHDFGKLEICGFYPTA ERPEKIVLKWHQAVGPDYLPERLKELIPTRSEDLMILDYKQGEMYCLDHVFEHNGLPYV NADGEIVENLPSEAVR" gene complement(52444..56889) /gene="edeP" /locus_tag="BP422_RS11465" /old_locus_tag="BP422_11145" CDS complement(52444..56889) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: Condensation_Starter (0-281). E-value: 4.4e-75. Score: 244.7. Matches aSDomain: nrpspksdomains_BP422_RS11465_Condensation_Starter.1" /NRPS_PKS="Domain: AMP-binding (446-839). E-value: 4.3e-106. Score: 346.9. Matches aSDomain: nrpspksdomains_BP422_RS11465_AMP-binding.1" /NRPS_PKS="Domain: PCP (948-1010). E-value: 2.3e-14. Score: 45.3. Matches aSDomain: nrpspksdomains_BP422_RS11465_PCP.1" /NRPS_PKS="Domain: Epimerization (1026-1329). E-value: 1.7e-97. Score: 318.9. Matches aSDomain: nrpspksdomains_BP422_RS11465_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (1335-1478). E-value: 3.5e-33. Score: 106.6. Matches aSDomain: nrpspksdomains_BP422_RS11465_TIGR01720.1" /NRPS_PKS="Domain: NRPS-COM_Cterm (1462-1480). E-value: 5.2e-07. Score: 21.4. Matches aSDomain: nrpspksdomains_BP422_RS11465_NRPS-COM_Cterm.1" /codon_start=1 /gene="edeP" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127: condensation domain-containing protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727233.1" /locus_tag="BP422_RS11465" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11145" /product="edeine non-ribosomal peptide synthetase EdeP" /protein_id="WP_236841447.1" /sec_met_domain="AMP-binding (E-value: 2.3e-113, bitscore: 377.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 4.5e-09, bitscore: 35.1, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 1.3e-51, bitscore: 173.9, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MWYTEKLHPQLPIHTLGGMVRVQGKVKLDVLEAAIHLFIQKNDAL RLNYQEEETVLQFAGEYEPQPLQVFDFRQEPNAPDRCRQFLQALFTKPFSIGREPLFYF CLIQLSDEEAGYFVKLHHLIADGWSISIMTEQIAHYYDTLLAGGTVHVGDEHPYQAFVE REHAYSLSERFEKDKRYWRDKFQSLPVITTLQKATDTTEGKRKVYAFNPEDSTRIRQYA DQMKCSLNSLFVALVSLYLQRCTRQEEIVIGTPLLNRSGKVERKIFGMFTSTMPFRLAV PMEMDAFDYVKYVNRELTSCFFHQKYPYDLLAQELELKKHGYDSLFQICVNYYSTQLPF TLGGYPVTNEEFYNGHQLYSLQVIIREWATDERLTLELDYKIAEYTENDVDRIADHLVR LLNQIISNPEVPLSNLNFLADEELALQLNAWNDTAAPYPSEKTVVQLFEEQVIRSPQGV ALESEGRTLTFQELHDQVNRLAQSLRNRGVGPGVIVALLADHSPEMIIGLLAVLKAGGT YLPIDPQLPSQRIEYLLSDSEADLLLRHTSRTKDISWSKEILELGDSSLYRNDGEFLES VNQPDDLAYVIYTSGSTGNPKGVMVTHRGLVNYISWAKDRYLSCPEEAFAFYSSLAFDL TVTSIFCPLVKGNRMVIYPHSDSEFVLSRIFSDGRSHVVKLTPAHLFLLQEIALPSTTV KRVIVGGEDLKVSLAEAIHAKWNGQIEILNEYGPTETVVGCMIYQYDPATDVEGSVPIG HPISNVQLYILDSYGKPIPIGSTGELFISGDSVARGYLNREELTQERFLPNPFQRGKVM YKTGDLVRYRPNGVMEYLGRADYQVKIHGYRIELGEIEQQLLGHSSVREAVVIDRLDTW GRKYLCAYLITETSFREKELREELAGRLPAYMIPSQIVQLEQFPLTSNGKVDRKQLPEP VIERRGAEDETSPRDEFDKLLVEVYEDVLGRSPFGLHDPFSQLGGDSIKAIQVSYRLHQ RGIKIPVRDILIYDTIAELKARSDWSWGVEQISQEPCTGELPSSPIVSWFLSQQFRNAD HWNQSLLLESKEKVTLEEFEASLSALVNHHDCLRLNYSAKEGKLFYNERHLTNRVSVSY VDLSSVPQEEQESRMLEAMRACAVSFKLEESLLFTGCLFELGPDRPQRLFLTAHHLVVD GVSWRILLEDLMSALASLKRNEPIVLPDKTHSMQAWIKEVTAFYQSNQASNEKAYWDMF SIPEDKLPTDYDFGEDLVEYSATSTRTLSAEMTSRLLTTANRMFNTGPQDLLVAALTRT LSDVFDRERLLLVMESHGRESSIHTMNVTRTVGWFTSMYPVLFETNPSNRTDHLKAVKE KLRQIPMGGLGFGWLKPQLLAAEEKSHVRFNYLGSVDNQLSDDLVLMGGNLAVDAGVGN HLTALLDVAALIRQGELQVSVTFSLRKYREETMEKLLALFFNELEQLIDHCCRQEVPEF TPSDFEDVELTQKELDLLFG" aSDomain complement(52450..52503) /aSDomain="NRPS-COM_Cterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_NRPS-COM_Cterm.1" /evalue="5.20E-07" /label="BP422_RS11465_NRPS-COM_Cterm.1" /locus_tag="BP422_RS11465" /protein_end="1480" /protein_start="1462" /score="21.4" /tool="antismash" /translation="PSDFEDVELTQKELDLLF" aSDomain complement(52456..52884) /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_TIGR01720.1" /evalue="3.50E-33" /label="BP422_RS11465_TIGR01720.1" /locus_tag="BP422_RS11465" /protein_end="1478" /protein_start="1335" /score="106.6" /tool="antismash" /translation="DHLKAVKEKLRQIPMGGLGFGWLKPQLLAAEEKSHVRFNYLGSVD NQLSDDLVLMGGNLAVDAGVGNHLTALLDVAALIRQGELQVSVTFSLRKYREETMEKLL ALFFNELEQLIDHCCRQEVPEFTPSDFEDVELTQKELDL" aSModule complement(52456..56889) /complete /domains="nrpspksdomains_BP422_RS11465_Condensation_Starter .1" /domains="nrpspksdomains_BP422_RS11465_AMP-binding.1" /domains="nrpspksdomains_BP422_RS11465_PCP.1" /domains="nrpspksdomains_BP422_RS11465_Epimerization.1" /domains="nrpspksdomains_BP422_RS11465_TIGR01720.1" /locus_tags="BP422_RS11465" /monomer_pairings="Asn -> D-Asn" /starter_module /tool="antismash" /type="nrps" CDS_motif complement(52816..52869) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0014" /evalue="5.50E-05" /label="NRPS-E6" /locus_tag="BP422_RS11465" /protein_end="1358" /protein_start="1340" /score="15.7" /tool="antismash" /translation="VKEKLRQIPMGGLGFGWL" aSDomain complement(52903..53811) /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_Epimerization.1" /evalue="1.70E-97" /label="BP422_RS11465_Epimerization.1" /locus_tag="BP422_RS11465" /protein_end="1329" /protein_start="1026" /score="318.9" /specificity="E activity: active" /specificity="Active site motif: HHLVVDG" /tool="antismash" /translation="TGELPSSPIVSWFLSQQFRNADHWNQSLLLESKEKVTLEEFEASL SALVNHHDCLRLNYSAKEGKLFYNERHLTNRVSVSYVDLSSVPQEEQESRMLEAMRACA VSFKLEESLLFTGCLFELGPDRPQRLFLTAHHLVVDGVSWRILLEDLMSALASLKRNEP IVLPDKTHSMQAWIKEVTAFYQSNQASNEKAYWDMFSIPEDKLPTDYDFGEDLVEYSAT STRTLSAEMTSRLLTTANRMFNTGPQDLLVAALTRTLSDVFDRERLLLVMESHGRESSI HTMNVTRTVGWFTSMYPVLFET" CDS_motif complement(52912..52956) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0013" /evalue="3.30E-08" /label="NRPS-E5" /locus_tag="BP422_RS11465" /protein_end="1326" /protein_start="1311" /score="25.6" /tool="antismash" /translation="VTRTVGWFTSMYPVL" CDS_motif complement(53260..53298) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0012" /evalue="3.40E+01" /label="C3_LCL_132-143" /locus_tag="BP422_RS11465" /protein_end="1210" /protein_start="1197" /score="-2.5" /tool="antismash" /translation="SMQAWIKEVTAFY" CDS_motif complement(53359..53424) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0011" /evalue="3.40E-13" /label="NRPS-E2" /locus_tag="BP422_RS11465" /protein_end="1177" /protein_start="1155" /score="41.6" /tool="antismash" /translation="LFLTAHHLVVDGVSWRILLEDL" CDS_motif complement(53638..53709) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0010" /evalue="6.50E-03" /label="C2_dual_024-063" /locus_tag="BP422_RS11465" /protein_end="1084" /protein_start="1060" /score="9.1" /tool="antismash" /translation="KVTLEEFEASLSALVNHHDCLRLN" aSDomain complement(53860..54045) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_PCP.1" /evalue="2.30E-14" /label="BP422_RS11465_PCP.1" /locus_tag="BP422_RS11465" /protein_end="1010" /protein_start="948" /score="45.3" /tool="antismash" /translation="KLLVEVYEDVLGRSPFGLHDPFSQLGGDSIKAIQVSYRLHQRGIK IPVRDILIYDTIAELKA" CDS_motif complement(54340..54405) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0009" /evalue="1.90E-11" /label="NRPS-A_a8" /locus_tag="BP422_RS11465" /protein_end="850" /protein_start="828" /score="35.9" /tool="antismash" /translation="YLGRADYQVKIHGYRIELGEIE" aSDomain complement(54373..55551) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_AMP-binding.1" /evalue="4.30E-106" /label="BP422_RS11465_AMP-binding.1" /locus_tag="BP422_RS11465" /protein_end="839" /protein_start="446" /score="346.9" /specificity="substrate consensus: Asn" /tool="antismash" /translation="FEEQVIRSPQGVALESEGRTLTFQELHDQVNRLAQSLRNRGVGPG VIVALLADHSPEMIIGLLAVLKAGGTYLPIDPQLPSQRIEYLLSDSEADLLLRHTSRTK DISWSKEILELGDSSLYRNDGEFLESVNQPDDLAYVIYTSGSTGNPKGVMVTHRGLVNY ISWAKDRYLSCPEEAFAFYSSLAFDLTVTSIFCPLVKGNRMVIYPHSDSEFVLSRIFSD GRSHVVKLTPAHLFLLQEIALPSTTVKRVIVGGEDLKVSLAEAIHAKWNGQIEILNEYG PTETVVGCMIYQYDPATDVEGSVPIGHPISNVQLYILDSYGKPIPIGSTGELFISGDSV ARGYLNREELTQERFLPNPFQRGKVMYKTGDLVRYRPNGVMEYLGRADYQVKI" CDS_motif complement(54487..54576) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0008" /evalue="1.10E-15" /label="NRPS-A_a6" /locus_tag="BP422_RS11465" /protein_end="801" /protein_start="771" /score="49.6" /tool="antismash" /translation="PIGSTGELFISGDSVARGYLNREELTQERF" CDS_motif complement(55081..55140) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0007" /evalue="4.00E-11" /label="NRPS-A_a3" /locus_tag="BP422_RS11465" /protein_end="603" /protein_start="583" /score="34.6" /tool="antismash" /translation="AYVIYTSGSTGNPKGVMVTH" CDS_motif complement(55324..55365) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0006" /evalue="5.00E-05" /label="NRPS-A_a2" /locus_tag="BP422_RS11465" /protein_end="522" /protein_start="508" /score="16.5" /tool="antismash" /translation="LAVLKAGGTYLPID" CDS_motif complement(55780..55815) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0005" /evalue="8.90E+00" /label="C3_LCL_132-143" /locus_tag="BP422_RS11465" /protein_end="370" /protein_start="358" /score="-0.6" /tool="antismash" /translation="YSLQVIIREWAT" CDS_motif complement(55891..56004) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0004" /evalue="1.30E-08" /label="C67_starter_14fromHMM" /locus_tag="BP422_RS11465" /protein_end="333" /protein_start="295" /score="27.4" /tool="antismash" /translation="RELTSCFFHQKYPYDLLAQELELKKHGYDSLFQICVNY" aSDomain complement(56047..56889) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS11465_Condensation_Start er.1" /domain_subtypes="Condensation_Starter" /evalue="4.40E-75" /label="BP422_RS11465_Condensation_Starter.1" /locus_tag="BP422_RS11465" /protein_end="281" /protein_start="0" /score="244.7" /specificity="C activity: active" /specificity="Active site motif: HHLIADG" /tool="antismash" /translation="MWYTEKLHPQLPIHTLGGMVRVQGKVKLDVLEAAIHLFIQKNDAL RLNYQEEETVLQFAGEYEPQPLQVFDFRQEPNAPDRCRQFLQALFTKPFSIGREPLFYF CLIQLSDEEAGYFVKLHHLIADGWSISIMTEQIAHYYDTLLAGGTVHVGDEHPYQAFVE REHAYSLSERFEKDKRYWRDKFQSLPVITTLQKATDTTEGKRKVYAFNPEDSTRIRQYA DQMKCSLNSLFVALVSLYLQRCTRQEEIVIGTPLLNRSGKVERKIFGMFTSTMPFRLAV " CDS_motif complement(56056..56145) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0003" /evalue="1.30E-09" /label="C5_starter_265-294" /locus_tag="BP422_RS11465" /protein_end="278" /protein_start="248" /score="30.4" /tool="antismash" /translation="EIVIGTPLLNRSGKVERKIFGMFTSTMPFR" CDS_motif complement(56467..56529) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0002" /evalue="1.30E-07" /label="C3_starter_134-155" /locus_tag="BP422_RS11465" /protein_end="141" /protein_start="120" /score="24.4" /tool="antismash" /translation="HHLIADGWSISIMTEQIAHYY" CDS_motif complement(56743..56856) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_BP422_RS11465_0001" /evalue="2.00E-07" /label="C2_starter_024-063" /locus_tag="BP422_RS11465" /protein_end="49" /protein_start="11" /score="23.6" /tool="antismash" /translation="PIHTLGGMVRVQGKVKLDVLEAAIHLFIQKNDALRLNY" misc_feature complement(57074..57087) /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 20.52" /tool="antismash" misc_feature 57074..57088 /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: medium, score: 22.68" /tool="antismash" misc_feature complement(57089..57103) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: medium, score: 23.26" /tool="antismash" gene 57251..57688 /gene="edeQ" /locus_tag="BP422_RS11470" /old_locus_tag="BP422_11150" CDS 57251..57688 /EC_number="2.3.1.-" /codon_start=1 /gene="edeQ" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743538.1" /locus_tag="BP422_RS11470" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11150" /product="edeine self-resistance N-acetyltransferase EdeQ" /protein_id="WP_088907840.1" /transl_table=11 /translation="MSVTLREVTLENWEECIELEPTPEQSEFVAPNLYSIAESKFQTTF VPLAIYHDDTMVGFVMYGLDPDDGNYWIYRLLIDAKYQRLGYGRAAIAQVIDILKAKVD CQKIVIGYAPANVAAENLYASLGFQKNGMVLFGETIAELNF" tRNA complement(57845..57926) /anticodon=(pos:complement(2531853..2531855),aa:Leu, seq:caa) /inference="COORDINATES: profile:tRNAscan-SE:2.0.12" /locus_tag="BP422_RS11475" /note="Derived by automated computational analysis using gene prediction method: tRNAscan-SE." /old_locus_tag="BP422_11155" /product="tRNA-Leu" gene complement(57845..57926) /locus_tag="BP422_RS11475" /old_locus_tag="BP422_11155" tRNA complement(57972..58056) /anticodon=(pos:complement(2531982..2531984),aa:Tyr, seq:gta) /inference="COORDINATES: profile:tRNAscan-SE:2.0.12" /locus_tag="BP422_RS11480" /note="Derived by automated computational analysis using gene prediction method: tRNAscan-SE." /old_locus_tag="BP422_11160" /product="tRNA-Tyr" gene complement(57972..58056) /locus_tag="BP422_RS11480" /old_locus_tag="BP422_11160" gene complement(58149..58466) /locus_tag="BP422_RS11485" /old_locus_tag="BP422_11165" CDS complement(58149..58466) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249077.1" /locus_tag="BP422_RS11485" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11165" /product="hypothetical protein" /protein_id="WP_088907841.1" /transl_table=11 /translation="MYYYGNETIMSLEQVLRLKASEVRILEWVRTYEFLENSYGIDEAV PYFLEIKCEEGQVKIRKNRILDFPEYSCEEEATFQEVDEALRVFHEWAQEILAKKESQS K" gene complement(58533..59099) /locus_tag="BP422_RS11490" /old_locus_tag="BP422_11170" CDS complement(58533..59099) /GO_function="GO:0015036 - disulfide oxidoreductase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249078.1" /locus_tag="BP422_RS11490" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11170" /product="thioredoxin family protein" /protein_id="WP_088907842.1" /transl_table=11 /translation="MGANVAHKFRTGLKPQVFVESMTKNQDTYQNWSDAFSWEDEQDRA FFASLQHRDDLRCLILAADWCGDVIRNLPVVLHALKETDMPVEIMVMEQHLDLMDEFLT MGGRAIPVVIFADTGGHVLAKWGPRPKHVQAVMTAFKQQNPDRNAPDYEEKIKVARAEM LEQYGEGTGYQQVIVKELRELLSSI" gene complement(59127..59297) /locus_tag="BP422_RS11495" /old_locus_tag="BP422_11175" CDS complement(59127..59297) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891498.1" /locus_tag="BP422_RS11495" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11175" /product="YycC family protein" /protein_id="WP_088907843.1" /transl_table=11 /translation="MRPLQISPETAVKLAEALQVPLERLMHMPQHILLQKMMELANQEK EANEAADKNQE" gene complement(59561..59758) /locus_tag="BP422_RS11500" /old_locus_tag="BP422_11180" CDS complement(59561..59758) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727217.1" /locus_tag="BP422_RS11500" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11180" /product="hypothetical protein" /protein_id="WP_088907844.1" /transl_table=11 /translation="MAKGKKIKKKDTRQHPNQMQLKIVSSQTCQICKQQCARGLAYLEQ MSRPGAIGFGVPCILTRQKP" gene complement(59931..60464) /locus_tag="BP422_RS11505" /old_locus_tag="BP422_11185" CDS complement(59931..60464) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1241: lipoprotein dsbF" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727215.1" /locus_tag="BP422_RS11505" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11185" /product="TlpA disulfide reductase family protein" /protein_id="WP_088907845.1" /transl_table=11 /translation="MKKLLLAVIVLLGVGLSVWEKPQETAAIVAEVQKPEVGFAAPHFT LTGLDQQTYKVEGKRAKPLVLNFWASWCGPCKMEAPDLQKVYEKYGGQVDLYGVNVTSN DSPEAAMAFVTNYKLTFPIPMDVAGTVSNRYKVLAFPTTYLIDADGIVRKKIIGMVDAP TLELELRQLLSPKP" gene complement(60488..61198) /locus_tag="BP422_RS11510" /old_locus_tag="BP422_11190" CDS complement(60488..61198) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_process="GO:0017004 - cytochrome complex assembly [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743533.1" /locus_tag="BP422_RS11510" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11190" /product="cytochrome c biogenesis protein CcdA" /protein_id="WP_088907846.1" /transl_table=11 /translation="MTGDITVFLAFAAGFLSFISPCCLPLYPSFLSYITGVTIDEVKKG RAVFRKQAFLHTFFFIVGFSIIFVALGLSTSWIGSLFTDQQDLIRQLGGILLAVIGLVM LGVFKMDWMMRSFKIDLKSRPLGYTGSILVGMTYAAGWTPCVGPILSGIIVMGVSNPSS ALAYTLAYTLGFAIPFFVMTFFISKVKAIVKYSDLFMKIGGAIMILFGILLYTDKLTDI TRVLIQMYGGFTGF" misc_feature 61201..61216 /note="TFBS match to CsoR, Copper-responsive repressor, confidence: weak, score: 22.08" /tool="antismash" misc_feature complement(61281..61296) /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 21.56" /tool="antismash" misc_feature complement(61343..61352) /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: strong, score: 18.04" /tool="antismash" gene complement(61355..61885) /locus_tag="BP422_RS11515" /old_locus_tag="BP422_11195" CDS complement(61355..61885) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249083.1" /locus_tag="BP422_RS11515" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11195" /product="DinB family protein" /protein_id="WP_088907847.1" /transl_table=11 /translation="MYFRKPQSDDYPAQFETYIKIAPEGDLNELLRAQEEEILALFRSC GEEQSMYRYQEGKWSVKEVLGHIMDTERIMSYRLLCASRGDKTPLPRHQDIFVSLTNFD RRPLADLIEEFQTVRSATRSLVTGLTEDELNRSGVIIQDKTTAAALVYFILGHAAHHLH IFQERYMSYLSKI" gene complement(61984..63210) /locus_tag="BP422_RS11520" /old_locus_tag="BP422_11200" CDS complement(61984..63210) /GO_function="GO:0005215 - transporter activity [Evidence IEA]" /GO_process="GO:0006810 - transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1029: RND family efflux transporter MFP subunit" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743531.1" /locus_tag="BP422_RS11520" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11200" /product="efflux RND transporter periplasmic adaptor subunit" /protein_id="WP_088907848.1" /transl_table=11 /translation="MKLSKKPVILALLAITLVAGCSSPQAETPPTETVEAATPVQVGTV ATGTVVSDSGLTAKLAPSEEVQVSPKVGGKISSLPVKLGQYVTKGQVLFKLDEKDLVNG VKQAEAAYNVSKASLNQAGSSSDQGLVQAKNSLKQAETALQDAKVNQQRMQQLFSQGAI SAQQMEQANSQLTTAQTSYDNAMQALQSAGQKTSVQVSEASVQQAQVSLQNAREQLANA TVTSPINGYISSVNGAVGQMAGQQPVVVVVNTNPLLVKANLSEADITKVKVGTTVKVNV QSSGKTIDAKVTAMSPVMDTQLKAYPVEITIPNPSNELKSDMVVNVTFPSAGESGAKSI VVTRGAVFDRDGKQYVFKLEGDIAKQVEVTTGKSSSDQIEILTGLSAGDKIVVKGQTLL QDGGKVTIQ" gene complement(63239..66376) /locus_tag="BP422_RS11525" /old_locus_tag="BP422_11205" CDS complement(63239..66376) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1049: AcrB/AcrD/AcrF family protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743530.1" /locus_tag="BP422_RS11525" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11205" /product="efflux RND transporter permease subunit" /protein_id="WP_088907849.1" /transl_table=11 /translation="MNLSELSIKRPVTMIMLTLAMLIFGFVSLPRLAIDLMPDLNFPVA VVVTSVDGGSPSEVEKLVTKPIEDALATVSDLDSIQSVSMEGASQVILMFNWGTDLDQA TLDMREKVDQVRGSLPDSARAPRVLRIDPNSTPIIEFAVTGEQDINKLKKMAEDMIQSR LERIDGVASASISGGQSRIIDVTVDPAKLAAYGLSLDQVQQALQSSNLSGSGGAVREGD AKLNIRVQGEFADVEQIALTPISVGGNSIRLSDIAEVKDTHQDVTQLSYVNGKPSLGVK VTKASGGNTIEVADDVKAELEKIKSELPEGVQIITTLDTSTYIKDSVYTTAEHALLGGG IGMILLFFFLGSLRSMVIAVIVLPVSIVATFLLMYMSGQTINLISLSGLTLGLGSLIDF AVVMLENVFRHREQGKGMMEAALDGSKEVGTAVMASALAQICVFLPIALTEGIASELFG PLALTVVYSHIAALVFSILLVPMLSSRILNKIPSHTHHENYRGINPVTWFNIGFSKVEK GYQRLLKWSLGHRKTVMISSVVLMVGSLALTPMIGAEFIPAMDQGQVNISIKMPNGTVL AETEKVTRQVEEIVNTVPEKDIVSTSVGSNASPIASTLSSNQGTISLMLVDLKERTRSS NEIVMDLQEKLKHIAGPEIKVSAPAGMSTGSPIQLKVSGDDLAVLKDISGIIKGEIEKV PGTSNVTTSLEESRQELEVKINAEKASLYGLTTGQILSSVRTSFQGQTVTYYRTGDDEI DVNLKLPKTYQEDINFLNNMRISAPGGAQIALTSVATISKVDVPVSINRANSSREVQVT SDLAGRDLSSVTREVQEKISKLNLPDGYKVDFGGQSEEMMESFSSLALAIVLSVVLLYM VMAAQFESFYTPFIIMFSVPPTVTGVLLGLLATGTTISVGVLIGYILLIGLVVNNAIVL IDYVNQLRAKGMELFDAILHAGPIRLRPILMTTLTTILAIGPLAFSGGAGSETNAPMAV TVIFGLGFSTLITLVLVPVVASWFDDLGKKRRLKRKLKLEKKLEKKQKKINPALES" gene complement(66501..66851) /locus_tag="BP422_RS11530" /old_locus_tag="BP422_11210" CDS complement(66501..66851) /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1135: MarR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891506.1" /locus_tag="BP422_RS11530" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11210" /product="MarR family transcriptional regulator" /protein_id="WP_236841368.1" /transl_table=11 /translation="MAREVLMKELFQLAKLLQEASVLFTTISEQELDTSDVTWQQVLIL EQLGNGPKTMGDISKTVGLSYSTTSGLINRLEQENLVRRFRDQADRRVVWVSLTERVYQ QRDVKWGNSQTV" gene 67007..68242 /locus_tag="BP422_RS11535" /old_locus_tag="BP422_11215" CDS 67007..68242 /GO_function="GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1048: sensor histidine kinase" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249087.1" /locus_tag="BP422_RS11535" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11215" /product="sensor histidine kinase" /protein_id="WP_088907851.1" /transl_table=11 /translation="MIIRQRKKDFSLLKIMMKAIQKRLLIMWFSILIVLALLPDSFKRE TPLQFSLTIVLFICYLVVFWTSKKKWKPFQFELATVVLGIVSLLKSLILGGEGFGLMLP LAVFIGFHIHGRRALAYATFFGTCSTLFLYFEENLKFTHIISYILTYVGCYIGARGYRI QTEAYETNQQHLEQLQKAHTELQEAHLQLQEAALHSLQVAVLEERTRIARDIHDALGHS LTSLIVQLHALKYMLQDGPDNAQEAVRNMLGVAKQSLEDIRTSVHTLALDKTSLGLTPL RALLSQAQKHTGIKMELICSDLDIPLSQEMTITFYRILQEAITNSLRHSDAKEILVIIE QKKDILFLSIRDDGSITRDQKIKPGFGLTGISERIQLLNGTLAYRIREPHGFQLDFSFP IRQTEPERSMRT" gene 68239..68925 /locus_tag="BP422_RS11540" /old_locus_tag="BP422_11220" CDS 68239..68925 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family DNA-binding response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743528.1" /locus_tag="BP422_RS11540" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11220" /product="response regulator transcription factor" /protein_id="WP_088907852.1" /transl_table=11 /translation="MTGRQKEGAIRVVLVDDQTMIRQGLGYVIQMQSDMEVIGEASDGV EAVELIGALVPDVVLMDVQMPNKSGIEATREIMQQHPRTKVLILTTFDNHNYVVDGIRA GAVGYMLKDADSQEMLDLIRRAHQGEALFHTVTAAKALAEALQGQRETPDSTTTSQSVL LDELTDRELDVLQQIADGYRNDQIAQNLFISEGTVKTHVHRILQKMGVEDRTQAVAKAL RHKIVK" gene complement(69368..70894) /locus_tag="BP422_RS11550" /old_locus_tag="BP422_11230" CDS complement(69368..70894) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1003: sensor histidine kinase" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249090.1" /locus_tag="BP422_RS11550" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11230" /product="ATP-binding protein" /protein_id="WP_088907853.1" /transl_table=11 /translation="MKNRISKYLTHLVSAAVAKTFSFLSDHHYSALLLEDRENTEALFV QQITKWIEVVKVVDTYAFERELSEIAYKFSLLGMNLTYLQQFLRKCRDVIIEEMNNNTF SLASTDMERVELLQAQIRLYQSMDYILYQMDDVFNKNSHQVPVEKTPASPTSSAKGEDV TMLAEQELVQLVLQSSDIAVLMIDRQFRVIEANYAVCHLFGVDRNQLIGQNIDHALRPH VSERFVQWVIERGQSGHYVAEYRGKWTTVSTSPIYYGTEMWGAIAVLRNVTESKKYEEE LSKREALAAVGQLAAGMAHEIRNPLTAIKGFIQLLREQGEANRSESYFSVILTEIERID GLLNDVLVLARYRDDKIVSERFLVMDELYGVIRLLEPEANRRGIKLELDIAQGEWHVFG HRSRIKQAILNILKNALEALMTQGNLVHVKVYSSLNQVIIVVEDNGPGLSDSCLQNLFV PFYTTKQEGTGLGLSTTQRIIADHGGELYAENSPKLKGARFEIRLPLSIS" gene complement(71255..71545) /locus_tag="BP422_RS11555" /old_locus_tag="BP422_11235" CDS complement(71255..71545) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727197.1" /locus_tag="BP422_RS11555" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11235" /product="antibiotic biosynthesis monooxygenase family protein" /protein_id="WP_088907854.1" /transl_table=11 /translation="MYVSMNRLTVPADYQSHLERAFGNGGERMKEVPGFLEFLFLAPSE GDEYIVFTKWTDEESFKNWTESEAFKRAHTGTNPNSPVKSDLRNYAVKSHS" gene complement(71632..72540) /locus_tag="BP422_RS11560" /old_locus_tag="BP422_11240" CDS complement(71632..72540) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005830953.1" /locus_tag="BP422_RS11560" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11240" /product="hypothetical protein" /protein_id="WP_047067509.1" /transl_table=11 /translation="MKNRIYRIGYEWVSKRELLERLFMTDCILIEHKRMHPPQEDQDTE LPPEKEIHAVLVRSQRRPGEWVTFNGLYEIQTREPIPWIDSPLEYHQFGVELIPGNIRR EKAPQGRIPARTKLQIAAVRQDTVFVTVPGHPSRRYEMSLAHARFAKDNPTELEMKLQV YAFPPRNDIFVDWLLKEGRKTGIITRPNQERVEKSAFQVWEDLRQEYGISVSAALIAIK QALIVLDRAGVETDFPYPPQERSDISLFSESERDAFYSYQSVRCAMAAVAALLTVDPKD PLQDTLLMDIMLEQQINRRRE" gene complement(72628..73290) /gene="thiE" /locus_tag="BP422_RS11565" /old_locus_tag="BP422_11245" CDS complement(72628..73290) /EC_number="2.5.1.3" /GO_function="GO:0004789 - thiamine-phosphate diphosphorylase activity [Evidence IEA]" /GO_process="GO:0009228 - thiamine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="thiE" /gene_functions="biosynthetic-additional (smcogs) SMCOG1280: thiamine-phosphate pyrophosphorylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249093.1" /locus_tag="BP422_RS11565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11245" /product="thiamine phosphate synthase" /protein_id="WP_088907855.1" /transl_table=11 /translation="MRNIQRLREKMGVYFVVGTQDCGYSSEKTVQIVEAALRGGVGTLQ LRDKGSKLTAQEQYELGRQLQQLCRDHDTLFFVNDDVDLAIRLQADGVHVGQDDMALAE VRAKVGSEMYIGVSAGTVDEALAAQNGGVDCIGVGAMFATRSKADAGEPIGPVGLAEIR KAVGNDLPIVGIGGITLENAAEVLAAGADGVAIISAISQAESPEEAAQALQQIVRSR" gene complement(73294..73917) /locus_tag="BP422_RS11570" /old_locus_tag="BP422_11250" CDS complement(73294..73917) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1280: thiamine-phosphate pyrophosphorylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727194.1" /locus_tag="BP422_RS11570" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11250" /product="thiamine phosphate synthase" /protein_id="WP_088907856.1" /transl_table=11 /translation="MSSTRELHVITSGRHSLDDVLRMAEAAYAGGMNFLHIREKQRTAK ECMDWVKALANVIPLSSLIVNDRVDVAAASGCAGAHLAYHSLSPVEARMVLKTGQKIGR SIHSTEEAQQAIAAKVDYLLYGHIFASGSKPGLAPRGTIELARMTARWHVPIIGLGGVT PDRTAQVLEAGCAGIAVLSGITDATDAKSAASAYREALDRWEGK" gene complement(73901..74263) /locus_tag="BP422_RS11575" /old_locus_tag="BP422_11255" CDS complement(73901..74263) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891515.1" /locus_tag="BP422_RS11575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11255" /product="hypothetical protein" /protein_id="WP_088907857.1" /transl_table=11 /translation="MTEPMQNVQPVTLSSQAFLLLCRLYDGCYDELKQNEQVRELVESI GDILLAGVETLEKQETKPKNITFPLTVQQAFFLRRLVIELLAQSPTDKEDRTTHWLQEC VTALAGGGVQPDVKHS" misc_feature complement(74218..74233) /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2, activator of antibiotic production, confidence: weak, score: 16.94" /tool="antismash" gene complement(74447..74578) /locus_tag="BP422_RS32550" CDS complement(74447..74578) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS32550" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_255413062.1" /transl_table=11 /translation="MGKNNNSKDLGKNRGKTLDENDRNTNLRQSNHNDRNEGTAKDR" gene complement(74634..75050) /locus_tag="BP422_RS11580" /old_locus_tag="BP422_11260" CDS complement(74634..75050) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017249097.1" /locus_tag="BP422_RS11580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11260" /product="DUF3054 domain-containing protein" /protein_id="WP_088907858.1" /transl_table=11 /translation="MRLRLSTPGYLLLLGDLIAFVLFVYYGKIIHNYSVTVMGIIETLA PFLVGWIIAILLFKSYGQRTYESAGRQLLSALITWTLAAPIGLLIRSWWTGVPTTLIFA GVTYFVTLAFLLGWRVPFAIGYAIYKRNRLHAIS" gene complement(75145..75735) /locus_tag="BP422_RS11585" /old_locus_tag="BP422_11265" CDS complement(75145..75735) /EC_number="2.-.-.-" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1111: GCN5-related N-acetyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891518.1" /locus_tag="BP422_RS11585" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_11265" /product="GNAT family protein" /protein_id="WP_088907859.1" /transl_table=11 /translation="MLNIEPVILKGKLVRLEPLRMAHVDGIWKAGAYEEIWPHMSVTIR TREDAQAFILQALKNEQAQTELPFVIIRQTDEQIIGSTRFLGIAKKDRGLEIGFTWLTP SVWKTGVNTECKWLLLRHCFEQLGCIRVQLKTDSRNLNSQRAIARIGGIREGVLRNHMV MPDGYIRDSVYFSILDREWPEAKQKLQLLLFGE" misc_feature complement(76498..76511) /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 20.48" /tool="antismash" misc_feature 76696..76711 /note="TFBS match to ClgR, Caseinolytic protease gene regulator, confidence: weak, score: 22.26" /tool="antismash" ORIGIN 1 gatttacctg tagatcaata ccctctaatc atacaggaaa gatcctacaa attcacgtta 61 cccttccgca caatttcttg aagctcgctc agttctctga tttcgtacgt cggctgaatg 121 ctcgtctgat tttccttgcc caaagggttg aaccagcacg tatcgatccc gtaattagct 181 cccccttgta tatcagaggt caacgaatct cccaccatca atacgttcgc cttctccgtc 241 cattgcagtt tggcaaacgc gtattcaaaa atttctctat ccggcttctt atagccgacc 301 tcttcggaaa taatcaggtg ctcaaaagcg ttgcaaagcg gtgaagcggc aattcttgcc 361 gtttgcacag aggcgaaccc attcgtaatg atcaccaaac ggcaatcctc caaactgttg 421 cacaattcaa ccgctcccgg taccaaatgc acttctttgc ccaaggattc gagataggcg 481 ctgccgaacg cctctgcatc gacgtctagc tgaacagctt tgaaaagtct tcgaaatctc 541 tctacgccca gctctgctag agtgatccgc cccttttcta aatcctccca caatccttta 601 ctgatctctt tgtaagtcgc tcgataatca aacgatcccg tagcgagtcc aaactgggca 661 aacgtctttt gcaaagcatt ttcttctgtc gttttgaagt caagaagtgt atcatctaca 721 tcaaatagta tgacttgata gcgcatggca acctccagaa atctttactg atcaagtatt 781 cgtacaaaac taacaccttt ctatcatatc aaaaacagaa ggccaaactg catacaaaaa 841 gcctcgaact gtatcattcg aggccatgaa agatatgtta gagaagcggc ttctggatca 901 acgtcgcgat tttgaatcga tgaacatgac catcgttgaa cgtggtcgat ccacttacaa 961 aatgaacatg tctttgaagc cgcgttggac tttttcgttt taacttccat ttcatcctat 1021 tctttttcgc catttattcc atccttccac ccttggctta ctcccactat attcaggtag 1081 acaaggaggc gaactggtca acagctcgtt tcctacgaaa atccatacta tcctagcttc 1141 attcgcattt tgtggctaaa ttggaaaaca cggatgaagt acttgaattg gttgagccac 1201 atcccgtaac gaaaatgaat gcgacaagta tgaatgcata agaaaaggaa actctcatcg 1261 aactcaacct ttcctattat ttccttccct tcattatcct atggttttta ctttgcagga 1321 agtacactcc ttctttccga atcatttctc aacatggtaa aaggaaggtg aagcaatgaa 1381 agcactctta gtcagtgatg tgcaaaacgg aattgtgaat tgtggggatt acaaagagga 1441 actttttttg atggaacagg taatcaaaga ttttaaagcg agcaatcgtc ctgtcatttt 1501 tatcagacat atcgatgatg cagaagaaag tccactaaat agaagctcta tcggttctga 1561 aatacaccct tcattaaaag gctattctga ctacttgatt gagaagcaaa ctcctagttc 1621 tttcttccaa acagaactca cacagacttt agaaaagtta gaggtagatc aactttttat 1681 gatcggtttt gagacggaat tttgttgtat gtttacggcg atcgctgcct atgaccgcgg 1741 atataaagtg acgttcatta aggacgcgac tggaacaacg aataccgccg aatcatacgg 1801 catgcaaggt ttagacatta aacggtttgt aggaaccgtt ctccgttggt cgagtgtcat 1861 tgaagtagta gactacgccg agtacgctga aaaatacaaa tgatgtaagc aggttgtacc 1921 ttttatccga gggctcgccg tcgatctccc aatggggatt agatggcgag tttttcaaag 1981 gtattcatag tattgaagtt tacctaaatg aatttttact acgctaagga gctttgtcat 2041 aaaaatagcc ggttacacca tatgatgtaa ccggttcatt atgtgctcac ataacacgat 2101 ttgaaactgt tatgaaaaac gcggcaatac ctttgcttat ctagaccgtt ccaaaaaatt 2161 accctctaca ttagatattt tcgttcttca gcgcttcaac gatattctgt tctttatgtt 2221 ttctagtcgc atagaggatt gatgtgccca caataaaaaa cacacctatc cctgcaatta 2281 aaagattcgc ccaaggcaac gtaaaagcaa attcaaaatt acggctaagg ctcttgtaga 2341 tgaaaaacat cacgcataaa ctaatcggta aaccgtaaat aagcgacttc attccataaa 2401 agaatccttc gaagcgtagc attttcttca tgccctttgg cgtcatgcca atggaagcca 2461 acatcgcaaa ctcacgtttt ctcaaggcca tccctgtcga aatcgtgttg atgatatttg 2521 ccatacaaat gagtccgatg agaatcacaa acccataaag gaatacggat atgactgtcg 2581 cgcgattcat tgcatcctga cgctcctcaa tcagattggt cgtatagaca tgtacatctg 2641 gatattcgtt aattatcggg tttatttcat tttccaatgc cgcagactgc tctgttgtaa 2701 attgaacctc gctgaaaatt tgctcagaca gcttatcgtt acctagttct cgtagcttgt 2761 caaagcctcg ttcagaaaca acaagtgtca ccgtaaaagc atcttcctgg tagcgtagca 2821 taaaaggtgg acgtttatct gtgatagaag caattcggac tttagctcct tcaatcagag 2881 tgttcgagag aggaatttct gatccctctt ggactgttag ttgagtgata tctgtaaaat 2941 tatgttgttc tttcaaggtg aaccgattga caagtattgc agaaatctcg tcaccttcca 3001 atttctttgc atcaatcccc gcggattgca ggtacgccac aaaagaggca tcatcaagag 3061 aaacaatgtt tgcagtcatg aagtatttcc cttctggatc aagggtatgg cgactggaga 3121 tgtctgtggt aacctcgttt tcgttgagga atagagcagc accgataagt tgggtattca 3181 cttttgttgt tgcgttttgg acagacatca attcatttgt taatgatcgt accctttcca 3241 gatcggctcc ccttgcgtat acggacagat catagggtag cggtgcttgc gccatattat 3301 aggacttatc catatacaac gaaaaggaag aagctgctag gtacaagatt acactgatcg 3361 caagagaaaa gacagttgag cgatagtggt gtttattcct tttcagattt tttaatccta 3421 gttccgcttc aaatccaaac aacttacgag tcatttttga tgtacgaaca tcttttcctt 3481 ttatttcgat atcctttgtc tggcggatcg cagttatcgg tgtaattccc gatgccctca 3541 ctgctggaaa ccatgcagaa atgaacagtg tcaaaacgga aaacaaaatg acagcaacca 3601 tactaaacgg ctctatcacc aatcgcatcg gttcactgac tacaaacatt ttttgaatga 3661 atgggctgag caaatggaga gtgacaccaa tgccaatgga cccaaaaaac aacccggctg 3721 gaatagctat gaccccgatc acagcagctt caaaaaatac agaagccctt ttttgctgtt 3781 tggttgcccc tatgctagat aacatcccta atgtgcgact acgctccgaa agcgagatcg 3841 caaacgcatt gtagattagt gagacagatc caatcagaat gatacttcca acggataaga 3901 ctgccagata catggtgtta agaaagtggg aatcattcga aatcccggaa taaagcaaaa 3961 gatcccggtt atacttgact tttactccat tcgatttaac ttgatccttt actccgctta 4021 ccttactagc aatcgtgtta ctcgtttcat aaatgttatt tcctaaacct ttaaaatcct 4081 tatattcaac acttaccgtg tagggaaaac cctcctctaa atccccctcg gaaagaccac 4141 taaatgcacg gtatgcagcc attgcttcct gctctttatc tggtgcttga acaatcccgg 4201 taatggtgta tgtttttgtc tttgtaggcg taaagacttc ctttgattga tagacataat 4261 cggtgcccaa cgtctcgctc ttcccatcta tattcaagct acggttacca aaatctaatg 4321 tgactacatc tccaaccttc cagcttaccc cggcggtttg aagaaactgc gatgaaagtg 4381 ccagttcatt ttcattctga ggcaaacgcc catcaattaa gcccacccct attacatcat 4441 gattactgtg tccagtaata tacaaataag gcttcacgct gtttggagag ttagaaagtc 4501 gtgcaaatcc gagcttctgg tcaatgtcgt atctttcaat cgcttctgta tttgtaataa 4561 ccgcaacatc ttctcctgca acatcgagaa aagctgcctg ccatttacca gcgtaggcaa 4621 tcgtgtttct ctgcatcata tccatgaaag aactactaat cgaaaatact gctgtaagca 4681 ttgcgacaga aatgacaact ccaatgattg taacaagtgt acggctttta ttctttttca 4741 tataacgtaa agtgagctga ttcacgatat tcatcgccgg atcacctcat ctctagaaat 4801 cctgccatcc tgaatgccaa taatacggtc cgcttgcaag gcaatggttt cgtcatgtgt 4861 aataacaatc agggtttgat ggcgttcttt gtgtaatttt ttcaagagct tcacaatctc 4921 agcactgttt ttgctgtcta gattcccggt aggctcgtca gccaatacaa tggcgggact 4981 gctaatcaag gcacggccaa tggacgcacg ctgctgctgt cctccagaaa gctggtttgg 5041 cagatgcttt aatcgctgtt gtagacccag agtctctacg ataccggaaa agatttcttg 5101 atttacttct ctaccgtcca acagcaatgg tagagtaata ttttcctcta cagtaaggac 5161 agggatcaga ttgtagaatt gatagataag cccaatctgt ctgcgtctga agatggccag 5221 tgccgtttca tccatcgcgt acatatcagt ctggtcaacg atcactttac cggatgtggg 5281 cgtatcaacg ccccccagaa tatgcaaaag ggtagactta cctgaaccag aaggtccaat 5341 aatcgccaca aactcccctt tttgtacgga aaatgagata tcgttcaatg cagtaacagc 5401 tgtttcgccg tcaccgtacg tctttgacag gttctctact cgcaaaatct ccatcatgag 5461 cctcctagat aagttattac gtttagaata gctgccaaac atgtctcgtc ggtgacattc 5521 attcttacaa ttttgtcatc tacatcattt gcttgtaaaa tttgattttg aatgttgtgc 5581 ctacaccaaa ctggctttcc ataaacacat cggcgttttg actttgcaag attgttttag 5641 acatggctag ccctattcca atactatcca ctcctgcatt cttccctttg taaaatcgtt 5701 caaaaatgcg cggagcatct tccggactaa tcccctcgcc actgtcggca atgacaatct 5761 gtgtatacaa tggtgtttcc tcacacgaaa tagcaatacg tcccccaacc ggcgtatgct 5821 ctatcccgtt tttaatcaca ttcaaaatgg cttcaaccgt ccagtttgca tccccatata 5881 cgaaaaggtc ttctttacaa gagaaagaaa gctcctgatt ttttaattcc atggggacaa 5941 ggagtggttc taatgccttg tttatcattt ttttgacaga taccaattcc ttcttgaaaa 6001 taacgctctg cacatcgatt ttggatagct tgagtaatga ggtcacgagc cattcaatac 6061 gcttcaactg attgataatc ttgcccaaga actcctccct cttttctttt ggcagactag 6121 ggttgtttaa caaatcagcc atgacaaaca tggaggcaag tggcgttttt agttgatggg 6181 agatattcga aagcgtttct gccaagtatt gtttgtcctt tttcagaaga gtagactgct 6241 cggacaacgt taatgtcact ttataaatat catttttcag aatgctcaat tcaccctcaa 6301 cgttatccct aatatccatc gtgggttggc ctgaatatac agaagccaaa taataagcga 6361 gcttactgat gtcttgatag cgtttgcggg taaacaagaa aaaacatgaa aggagcagaa 6421 ataccatggc aatcgccaca atccctgctt tccaatcgat tatccaaaga atagtgatcc 6481 caatgatgga aataaccacg ctatacatac ataacttccg gatttctttg tttttaagca 6541 taacttccac tcattcgata gccaagtccg cgtacggttt ctatcacttt gggattctgg 6601 ctatcatcct ccaacttttc tcgaagccgc ttaatgtaga ccgaaagggt attgtcattg 6661 ataaagttac catctaaatc ccaaatgccc tctaacaact gatttctgga tagaacttgc 6721 cctctactat ttatgaatgc caacagcaaa cggtattcta aagcagtcag catcacttcc 6781 tcagttcctt tgtacacttt agccagtttt gtatttacga caacatttcc aatcttcact 6841 ttgtcagtca ggttgggttc tttttgatag tgcctaaggg atgacttcat tcggctaatc 6901 agctcccgga tacgaaacgg ctttgtgatg tagtcgtctg ctcccatatc taacccccga 6961 accacattga tttcatcatc acacgcggtc aagaagatga caggtgcatc ctgattttct 7021 tttacaaatt cgcaaatctc atagccatta ccatctggca atgtcagatc cagtaaataa 7081 atatcaaaac gttgttgcct gattgtttca atggcagtat gtttcccttc acaaagaacg 7141 acttcataac cctcactgga aagcgaatag tgcaaaccat ctgcaatggt cttgtcatct 7201 tctactacta aaaccttcaa tgttcatcct cccgactatc tcttgttctc acatcagttt 7261 ttggtttcaa accatagttc agatagttct gtgtatacct ttagggaacc tgataagtat 7321 cacactcatt ctaaaatata gcttaagtca cacaaataca cgatccttta cagatcgttc 7381 agtcattgct atatgacaaa agatgtcata atgggcggtt tatactgaat ccatcaacga 7441 aacgattgga ggatttcggt atgataggtc tgcgtatttt tgcaaaatgg gtaatgatcg 7501 tagggttgtg cttgatgttt ctttcatctg gtatttataa gctctttgga catccagaga 7561 ccacaatcgc tttccaagca ttcgggtttc cccattggtt ccaagttgtg atcggtttag 7621 gcgaaatgct cggcgggtta ggcttactga tgaaaaagta tacgcgttac gccgcctata 7681 cgctcgcagt gattatgctt ggtgctacaa tcactcttct tttacacggt gacacgacta 7741 ctgtagcgat tccgtttgtc ttactcctcg ttttcttgct gatcggtcgt cagagtggta 7801 gcaaaaaaaa gtcgaatcat gctacgtcga tttaatccta tggctcgctc aaaaggccgc 7861 cagttcccac ccgtaaccag gtgaggatct gacggcctcc cgctttttct tcaagctcgt 7921 tcgtttacaa gtgctttttt ataaagtgta ggagcggtaa gaatcgctcc cttgccttcg 7981 cattcccagc aggattgctc taagtcatcc atcatgagac aaaatccatt ccctgctaaa 8041 aatcacctta ccttgtcctg attttaacac gaattcgcca tgtactgcca gccagttcac 8101 tattgcttcg acaggctctt cctttataga gaagcaatta tttatcacat acccttctgc 8161 ttgaaatcat agtaggtaaa gatagtaaaa aggagggatg acatgtggat caagaaaaag 8221 taaccatcaa aattaacgac aatggatcaa ttcgtgttac cggtgcagtt gagttgctgg 8281 atggagcaag tgacaagtat gatgtcggtt catctttttc actctgtcga tgcggtcaat 8341 ccgagaaaaa accgttctgt gacggcacgc ataaaaaagt aggctttgaa agtgcaccac 8401 gagcaaaatc atgatctgaa agagcgcaga tgcgctcttt tttcttttat caatcgcttt 8461 ttatgtcaaa ttgtttcctc gtattgacgg ggtttatttt ttatacctaa gataaagaca 8521 ttccgatcca gacgcaatga cgaagaactt tacttcgtca gttatggctg acatagttag 8581 gagtgcacaa tcatgtatgc acaaacagta cgttacgatc aatttggcga accccgtgaa 8641 gtattgaagg ttgaacaacg gctgattcaa cctctgaagc acgatgaaat tttggtaaaa 8701 atgagcgccc gtcctattaa tccttctgac gtcatcccga ttcgtggtgc ttacaagcat 8761 cgcatcaacc ttcccgccat tcctgggtat gaaggggttg gtaccgtaat ggatacaggg 8821 ccttttgctc ccctctctct tatcgggaaa cgtgtactgc ctttgcgcgg tgaaggtacg 8881 tggcaagaat acgtaaaaac gacagctgag ctagccattg cggttcctga ttcgatccca 8941 gatgatatcg cctgtcggtt gtacatcaac cccatcactg cgtgggtcat ctgcaatgag 9001 acccttcaac tgtcttctca tcaggttttg ttagtcaatg cagccaactc agccattggc 9061 cgcttgttta ttcaactatc cgctcttttc ggttttaggg tgatcgccat cgtccgagac 9121 gcaaaatata ccgaggagtt gatgcagctt ggggcgtggc atgtcatcga cagttctcat 9181 gtgtctattt atgatgccat catgagtgtc acgaacggac aaggtgcaca tgcgtctatt 9241 gattccattg gcggtccaga cggtttagaa ctggcgaaat ctacacgtgc cggcgggatg 9301 ttcttgtcgt taggtctttt atcgggagtt caagtggatt ggtcgatcat ctcgaaagag 9361 cttggcgttc tcccacaatt gtttttatta cgccactgga atcaacgaat ttccgtgtct 9421 acctggcacg aaacgtttga gaaagtcatc gagctcgttc agaatgggca gctcctttta 9481 gcagagcctg gagagaaatt tgctttgcat gaggtaattg aggccgtgca atttgcggag 9541 agccgtcatc gtacggggaa aatcatcttg gtgtaattac ttggatggaa tggaatcgta 9601 catcctaaac gctacttttc tacaagcaaa ataaatgata agctctcgct gtagcgaaaa 9661 tttagatggt aaagtgccta cacggctcct cgttctttag agatgtacaa gtggtttacg 9721 ttttaataac atcgaagcca aaaatgagcg ttttctcacc ctttttggct tcggtgaaac 9781 acaggaggtc ctatggctac tcatgaaaag aggtttctta aaaattatga atcaaaagcc 9841 tctaaatatc tgaacgataa agaaaaagca tctaatctcc taaaaaaagc aatgaaaaaa 9901 gcagacaaaa aaacgatcgg agatgcttgg gagaatttac agctactctt tcaaattttc 9961 ggtgattgga cgagtggaaa atatcgaaca atccctgtta aatccatttt gatgattatt 10021 ggcgggattt tgtactttgt ttcacccgta gacgccatca cagattttat tcccgttgct 10081 ggtttactag atgacgcgac aatcattgga ctggtgtttc gacaagtgag cagcgacctt 10141 actctataca aagagtggaa acaaaaagaa tttttacagg aataggtaaa atccattcga 10201 gtagagcgag gtgctttgat gacgtttcac gagtatttac gccatacatt tccaacatta 10261 atgcttagac cacctttgtt ttatagctgg gatattggaa tccgttttga gctgggtgtg 10321 gactacgatt accataacgt ttatgaaaat ggcccgtatt tacagggggt ttatacgcga 10381 gcgattactt tatgtaagac tttacatgca cctaacgatg atatctatat cgtagtggat 10441 gtaaacgatt ttggagacgg tggagctttc aagcgtaaat tgaacgtctt ttccaagtat 10501 gtgaagaata aatcactttt gtataagctc caacaaaata ccatccctta tgtttttccg 10561 gaagacgatg aaaatgaagt ctatcgaacg catcgattcg ccttgaagtg caagacatcc 10621 gacttttcat atgttccgat gataaaagca atctgtcgtc aggatatggg gttacaacca 10681 cgtattctat gacagagcca agatcgatca ggtattttcg taaatagaat cagttaaggc 10741 aacacatttc cggcagcacg atagatgtca taccactctt ctcgcgtcaa gcgaatatgg 10801 gctgctttca cggaatcttt cattcggtcg atattcgtcg tgccaatgac aggttgcatg 10861 ttcgccgggt gccgtagtag ccaagcgatg gcgattgtcg tgttggatac ttcatatcta 10921 gctgccattt catcgatttt cttgttcaac tcaggaaatt tctcgttccc aaggaaagac 10981 ccctcgaaaa atccatgctg gaacggcgac caaggctgaa tcgtaatatc atgcagcctg 11041 cagaagtcga gtacactgcc atcgcggttc acagccgagt tgttctccat attgacgttg 11101 aagccttgcg agatcatcgt cgcgttcata atgctaagct gcaactggtt agcgacgatt 11161 ggttgcttca catgtttgtt taacaactgg atctgcatcg gattttgatt ggaaacgcca 11221 aagtggcgaa ctttacccgt gctttccaaa agatcgaacg cttccgctac ttcttccggc 11281 tcgacaagcg tgtctggtcg atgaagcagc aatacatcca aatattcagt ttttagtcgt 11341 tttagaatgc catccactgc attcaaaata tgctctttgg aaaagtcgaa catgccgggc 11401 cgaatgccac atttcgattg caacaggata cgctcgcgaa cgctagagct catctgaatc 11461 gcttccgcaa atacttcctc acatctgcct tttccataaa tatctgcatg gtcgaagaag 11521 ttcgcccctt cttcaagcgc cgtttgtacg aagcgctccg cttgcagctt gtctagtgac 11581 cctatcctca tgcaaccgat tgcgatgaca ggtacttcta acttggtcgt gccgagtggt 11641 atggttctca tgtcaatcct ccgattctat tttttattgt gtcaattcga agcaatcgtt 11701 tcaacacacc ccactactgg taccataatg aaaaggacgg tgatccatgt tgaaatgaat 11761 tatccataga gctcattggt ttattcaact ctcaagactg agaatcctgc gggaatggaa 11821 atcgggttgg ataagaaatc caaagttaaa agtccttccc actaaaccat ggaaggactc 11881 tttgtttggt gtaacttccc tgtacacccg tgatacttct attttcgata gtaatatttc 11941 gcccattcgt tgatgatttg ctttttcgcc ttcgccttca ccttagggac atcacttgtc 12001 tcccaatctc gaatggcctc tcgaaatgac ttgtaaaacc agaaatcatt aatattccat 12061 gagcaaaaaa ttttccgata catgcgtccc gcatgaatgc cagcgctgta tcttcttaca 12121 gccttactgg ataaccgttt tgcgaacttt ttagctggcc cactcttgtc ttttacaacc 12181 gggaacttct tataacttct actcatcact aacctccttt ttgggaagtt aatgaccgta 12241 attcatttcc ttcatcgcac accctccttc ggggttatct acatgaaaat actcacgaac 12301 cacttaaaag tttcgcttcc aactcctgtt tttctgcaaa cattactgca caaacaaaaa 12361 aagcctttgt aagcaaaggc ttttcgatca tttcgtatgg agcgggtgat gggaatcgaa 12421 cccacgccgc aggcttggga agccggagtt ctaccattga actacacccg cagaatgtta 12481 ccgcatttcc attccaactg cttccaatta tatagctgtc tgaattattt gtctagtgtc 12541 tccaatcaag aaaagaccgc ccgggcatcg gccccgttcg gtcttccctg cttgcaattc 12601 catcaggcat gcgcaagtgt ttgctgcaaa ataattcgcc cactctccat tttcactact 12661 tgatcagcaa gatggaagta gcgatcgtcg tgtgtgatcg cgatgacaca tttgccctgt 12721 cttttcattt ctggcagcaa ggattcgtaa aagaattgac gatactctgg atcttggtcc 12781 gctgcccact cgtcaaagag gaaaatgggc cggtctctta ccagactgag cattaaggca 12841 aggcgcttgc gctgacccgt agacagcttc gtcgtgctaa acgttcccgt ttcatccact 12901 tctactttgt cagcaatgcg tagcacctct aaatatttgc tcacttcttc ttgcttcgct 12961 tggtaatcga ttccgtacat cttctcaaac aggtagaaat cactgaagat cgcggagaag 13021 aattcgcatc gttggtcagc attcactttt tggccgttca tgaaaaactc gccttcatcc 13081 tgctcgtaca atccggtaat cagcttggca aacgttgact tcccgctgcc gttcccacca 13141 acaatgaaga cgatttcccc ttttcggcag gagaagtcca gcggccccac ggaaaactct 13201 tcgccctcct tgtttttgta ttggaaccgc acctgttcag ttgaaaacgt ctcaaagtct 13261 tgcgcattcc gctcaaccaa gctttcctct cctcttctcg tttccactga taaggagtca 13321 agcaacgcat tcagtcgctg ccagctgatc ttgatgcgaa tcagctccgg cactgcattc 13381 aaaataccgt gaacaggtcc tgtcatatac agaaagacaa acacataact aatcagcatc 13441 tctttttgca gggaagggaa gagaaccggg aataaaaagg caactgtgcc gattaccaca 13501 acgaaaagca attccccaat caaatacacg ttcacaaatt taaattggcc cgctgatttc 13561 ttatgtcgat agtcagagca gcttctttcc atgtctgctt cgaattcttt tcgttgcgcc 13621 tgcgtcagat acagctcctt gaagcccccg atcatatcgg taatatagga gaaaaacaca 13681 ttttggatgt ctctggtttc ctcccatact ttgtttgcaa agcgacctgc cagcgtatac 13741 aatcctacag ccacaaaaat gacagccaga caaaataaaa atccgtatag gtccagcgag 13801 cccagataaa tgaagcaaaa cacgagtgta accgcactcg tcagcgccac aacgacacta 13861 ttcgcgaacg tactgatcgt ttccgtatca ttatttaacc ccgcatatat ttcaccgtta 13921 tccagtgtct cgtacttttg ataagaggtc cgaaaaattt tgcggatcag ttccattctt 13981 ttttcgtaga cgatttcatt tgtgatcaca atcaatcggc tacgcatcat tttctccccg 14041 acgatataca acaagatacc caggagaaaa tacaggaaaa tcgatgcatg aaacttgttc 14101 gtagatgtga gcgccagatt gatcataaaa ataatcagcg catttccaaa tccgctgatg 14161 agcccctgta tgacaataga cgtcatggat gtttcttgcg atttcgggaa caagcggatg 14221 agtgtgatgt agacattaaa cagtgcgagt cctgccacca acgcgtacat ggcgtaaaaa 14281 atggtgatcg gaagccaaac ctcgatgaac ggccatggta agcccataaa aaaaacatcc 14341 ggcaaatagt ataaggcggc ggtcaaaaca cttcccatga caacaaatgc aacaaaggat 14401 gcaaaacaaa ttcgccccgc attcgcggag agttttcgtt cgcctcgata gacttgcacg 14461 aaaatctgca cgattgcccc accaagtagc aacaaaagga taccaaggat cacgagagaa 14521 atgcttgcca gtcgatccgc ttgaagattg gtgtcagaca cgactacggg agcttctttg 14581 cctagtacga gattgacggc cccttctgcg ataacagatg cgttcaacga gttgatattg 14641 gtcaaaacga cggcgcccag cttttcttct ggacgaaata ccatgtacga agaaaatgca 14701 gggttattgc caccgtgcga aatttgccct ccaccatcct gataaatcat ccagcctgac 14761 gcatacgaga aaccgtctgt agcaggagct accgaacgat caggaagatg ggaagcacgc 14821 accagctcgg gacgaaacgc agatgcctcc caccccaact gaatctgcaa ccatcgttcc 14881 atatcgttta aatcggaaac gacataaccc gctggcgtat ttccccgata ttccggcgca 14941 tcatacacgc gtggggaaaa gaactcgatt ttgtgccctc ttgccatctc ctccacgggt 15001 gcctgtgcct tcaaaaaggt atgggttagt cccaatttgg caatgacttg ttgctgcaca 15061 tattgctcat aggtctctcc ggtgattttc tcaacaacat agcccaggat atcgtagtta 15121 atggtggcgt attcatactc ggtacccggc ttgcggacca gttcagtatg attaatcgct 15181 cgcacggttt cttcgatcgc attttcactg gaggaaatag ggatggaacc aatactttca 15241 aacggaatcc cgctggtatg gtacagcaaa tgcttaatca ggatcgtttc ctgttgtcct 15301 ttataggtaa cgcgaaacca cgggatatag ttctgaaccg ggtcttccag cgaaagtcgt 15361 ttttggtcga caagctggtg aactgctagc gctgtaaatg ctttggagtt cgatccgatt 15421 tcaaacaagg tgtcagaagt aaccggctct tgcttctggg tgtcagagaa accaaacgat 15481 tgcttgtaaa tggttttccc ctctttgacg accacaacgg ctgcaccagg gattttttcc 15541 gactccatgg ttttattgac cagctgctcg atttccgttg cgatttccgg atcctgtcga 15601 tcgttcgttt cggcgtacac ggacatactg ctggaaagta cgagaaccag acacatcagc 15661 aagaatgcta gttttcgtct cgactcatct atgatctttt gcagaatgat ccactccttt 15721 ttacgcactg cgtctgtggg aaagatcgca accagtacgt gatgtaattg ggattggata 15781 gaaaccgtgg cgaatcaaac tcgccacggt ttcttattac gcatcgcaca tatacacagg 15841 tttcgagtag aggcgcaagg tttctctcca ttttttaacc aatcgctccc actgttcttg 15901 ctcgatttgc tcttgtttca ataggctaat gggaatacac aagtttaata gacgcccatc 15961 tatttcaaaa cgggtaacac ccgcaggcaa tacatgccct tccgatacga tacgctccaa 16021 ttccgccaga ctgattggcg ggaaccgtat cagggctgct cctgtttctg gccattcgag 16081 catccctgtg ggcagacgat gcaccggatg gctatagttg taactgtcta ctaattgacg 16141 ccatagcgtc attcgccact catcatcctg ccgattctca tttggataca gatagaagcg 16201 ttccttgttc cctatcttca tttctgccac aggcgtttct cctaaacgct ctgtttccca 16261 ccgaaacaca gaatcctgct ccactgactg caaccatgca gcgactggca caatatgatc 16321 ccacatatcc aagtgaaaat cctcatgttc cactatctgt acggggatat gtttgcaccc 16381 gagcgcttga agagcaaagg tccgatgtgc accatcaatg atcaaatact ggccgttttg 16441 cataagaatc gccagcggag gatggcgcaa aatcccttcc tcctcaatga tctgtctagt 16501 cttgtgtagt cgcttgttct catgtgactc gtgcaaacaa atacgagatg actctaccag 16561 ttttagattt gccagcacat cgtacaaaat ggtaacctcc agttagtctt gcaagtgagt 16621 tccgatcccc tgcgagagtg cttgtttgta atagtaggca gcaatggcga tatcaaaaat 16681 cgccattccc atcggattaa acatgatggg ctcatcttgt ggaaattctt tcatctggtc 16741 aaggcagacg atatctgtga tggatttggt atcttctttt tgcaatcctc tctccagatg 16801 catgatctcg atgtccgtgt tctcacggca aacttcagtc cagtcgtcta cgataatgga 16861 gcgggtatag tcgagaattt ttggtgtaaa atcgcgtaac gacacattta acaacaaaga 16921 atgacgtttt ggttgcttgt caataaaacc atgcggtgat accgtgcacg tgatgaacac 16981 atctccctcg caatatgctt cttcccacgt ttgcgcgata accgttttct cttttatctc 17041 agccggaata tgctcctgct ggatacccgc aatgtcatag agaaccacct tgtcgatttt 17101 ctctcctaac aaggacgtga ccatttgcag atgaagtctg ccaatcggac caaatccgat 17161 aattccgacc gttacatttt gcaggggacg tacttgttcg taatgcttga ggagaagacc 17221 ggaaacagaa gcagttcgaa tgccgctgac cagggccgta ttaatcgttg ccacaggctt 17281 acccgttctg gcttcgttca ggatggtaat cgaatgcgcg cgttggatac cctcttggag 17341 gtttttcggg aaactggcaa tccacttgat tcccgccatg taagtatctc cgcctacaaa 17401 tgctggcatg gcaataatgc ggtttgacat gtcatgatat cgcaagtaag gtttaatcgg 17461 ctgtgcataa tcttccttgt gtaaggaatg cacagcatgt tcaatgacat caatggtttc 17521 cttccaattc ttgccaacct tttcaatatc actcgtgttt agatataaca tcgtgcagcc 17581 caccctgctt atcgtagtag atttattgga tactgcttaa ttgccaacga aagaatgctt 17641 ttgctgatgc aaccactgaa cccattcctg gttgtatacg gtattgacat acggcatacc 17701 accgtcgggg cataaaaaga cgacattagg cttgactaca tgcttttgat ctttgaaata 17761 gtttttaatc gcccagtaag aagtccccgt agatcctcca gcaaaaatgc catgctcagc 17821 gtacagctga tagcaagcct tgactgtgtc ctcctccgaa acatgaacga cctcatcaat 17881 gatcgcgccc ttgagtatgt caggccgcat gcttgatcca attcccggga tgtatcgttt 17941 ttgtggctct tgtccaaaaa tcactgatcc taccgtatcg acagcaatga tttttatatt 18001 cggatatcgt tctttcaatc gctgcgaaat tccagtaatc gtgccgccag agctaacgcc 18061 gataaaagca tagtccaatg tctcgaagct gtctgcgatc tcggctccca gtccgaagta 18121 atgggctcga gcgctatccg gatttccata ctggttggtc cagaacgagt tattcgtctc 18181 attgagcagg cgattgaccg tttggatgcg cgtaagaaga aatcctcctg tctcatcacg 18241 gtccgttact tttacgacct catgggaaaa cgccctgagc aaattctcat atacaggatt 18301 aatattgggg tcaatgactg gaataaattt aattccgatt tgcttgcata aagtcgccaa 18361 agcgatagca aaatttcccg aagaagactc gattacggta gtttcctgcg taatctctcc 18421 tcttttgatc gcctcctgta gtatgtaaaa ggcagccctc acttttacac ttcccatgag 18481 gttgttgtac tccagcttgc aaaacagatt gatgtgctca tgctcaagtt tgattaaagg 18541 cgtattgcca atcatgtgac ttattgccat cattttcgtt agcatgttga gccctctctc 18601 ccgttttttc ccgtcttcgt ctgatcgacc gaatatatct tggcccttcg atcaggcaga 18661 ttttgcatcc attttttgct ggatgtaacc tgccaacatt ttcatatcct gaaagttttc 18721 caaatggagc atgtcatcat cgaattcaat gccaaactct ttttcaacct ttacgaccga 18781 cttgataaag gtcaatgaat caatgtactc cgcaagttct ccgctttcgt tcacgtactc 18841 agaaaacaac tgtaggagcg tctcgtatac ttcgttttcc ttttccattt gagtccctcc 18901 atgtggtaga tgcttacaca acaacgccac cccgttccag tgctactctt gttttggtga 18961 ccgcctcaaa ttcctgcgtt tttatgctgc tgattttttg cagaacacga tgaaccatat 19021 cacagcgatt actgtcaaaa gccttcaaaa tcatattggt cgtaattttc cattgatgtc 19081 cgatattacg atacagctcg gcaagatctg caaagttttg atgcttctca ctgatcacct 19141 gcaggacatt ggcatacatc gctcgtgttt gtgccatgct gatcaagcta tggttaagga 19201 tatcgagatg atcgtctgta atctccactc cgctcgcgag aaaagcctct acgtctttga 19261 gaaaaggatc aagggatttc agccctacct cgacgttggc atcgtcgggt acatccaact 19321 cccgcttgat ttgacttgtt tcgtaacgac cctctagtac gcagagattg ctcctgactg 19381 cttccagcaa ctgttcaggt gtcggatgca gggaatctga aagtaccaat tcaaatgatc 19441 gattgtggag tggataccat tcgcctgtgc ctgcatcccg gtaggaagag ttactcgcct 19501 gtaaaaattg ctcgatgggc aacagacctt tgtagcggta gtaatcatcg acgatcagaa 19561 gctggttatc ttctcttcct gtgacaatga tgctatgcat ttcaggcagg tcctgataat 19621 aagggttgta cgggagctct gccatattgc agagaacgat tgtcggtacc tcccgttcca 19681 aacgttcttg tatatttgcc aaaaacaggt cgttttccgg ttcagcccgt ccttctacgc 19741 agatattgtg aatccacttc agctctctga ctgttctcat gtattgaccg tttagatcac 19801 cataaggaga atcctgcgtt tttagataga tggcaccgca ctgcttccag gctgtttcca 19861 aagcggaaaa gttcaggtat ttcagaaccg tgaagataga agcgccaatg caatccaggt 19921 tcggatgctt gctcggttgg atctcggcga gtgacatgag cactctcctt cctgtctatc 19981 gtaatggtaa acacatgcga ctatcggata tccgaatcac gttctcgcaa ggcgaatact 20041 tgttgtagaa attgactagt gagagacctc aacttatcga cagcggcttc caaatcggat 20101 cgattcaaca ttttttcttt gtataagcta agggcatagc gattcaccac gttattggat 20161 gtctgcaaaa tctcctccgc cagttcgcgt acagactgat ccgcccgtgg aatgtaccag 20221 tccactaatg tttcgatcca cagttctttc ccgcctaatt gaacgtagag ctcgtttaaa 20281 ttcgcttcat gaaaataggt gtctggctgc tccgtaagtg acagcaacag cgtaagctca 20341 cggccaactt gctgtttact ttcaactgct tttagtaaac gcagcaactc ctgctccgcg 20401 ctcgcacgca agcttgcttc gtcatctgta acgcgatcga gcaccataat cagccgggaa 20461 tgcggctcta gatttgcata aatctcctca agcgtttgat acgttgtgga aaatttatcg 20521 tactggattc gttgagcttg cccgcgcgtc aaatgattgt gattgatgat cgtataaacc 20581 tgcttgtcat ggtcgtagcc agtgatgaca gtgagatgat cggtatgttc cttctggtat 20641 tgcggtgtgt aaaaggtgta gtactcgtca aacgcaacca ttactggttt gccttgatct 20701 aattggcgaa tgatcgactc atgcaattca tccaggcgag cgacaggcac gagtttgacc 20761 cgatagccaa atttgtaaag catctcttca tccgacaaat atcccataac ctcagcatgt 20821 tcccgatatg aatagggata cccctcagca ccaagctgat aaccgcgctt caacccgaga 20881 aaaagcttca aatacggaat cagatgggca tcctgctcct ccattaataa agcgagaccg 20941 cgatcataac aattccattg acgccaggat aaatgactga catcggcata cgagctgcgt 21001 ttgatttgcg taccctgcca tgaattttcg tttcgttgtt gagtagtttg gattgcagta 21061 gcagctgcct ctgctttcgg aacctgttct tcttcagacc ccgccgcatc aagataggca 21121 gcaaaatcgg aaatcgtcaa atgggtaagc aggtcttgta ctgctacttc tcggttcatc 21181 cgctttgaaa tttcgctgat cattttaatc gcgatgatcg agtccccgcc cagatcgtaa 21241 aaattgtcat ggacatctac ttcttcaagc cccagaacat atccccaagt ctgagccagc 21301 tcttgctcta aaacagtgta ggtatcatct tttctcccac gtaccaccac gtttgccagc 21361 ttcgcttctc cagatttttg cggtgcaacg ttgtcttttt gtttcccggc atcctcgcca 21421 agagaatgaa gagaagagat gtccagccaa caacgtttac gctcaaacgg ataaacaggg 21481 aggtgcacgc ggcgcggttt tttaaacgta tacatggtac tccagcgtac atctgccccg 21541 ctcacataca attcgcccag ctctttcaga tcagacaact ctttgctttg cgccaacaaa 21601 agcttttgca atacagcatt ggcagcctta ttgatcgctt gttgttctgc ctcagtcagt 21661 atcccaggct ctctatcagc tttttcctgc gagataacct tgtgccagcc aaagaaaata 21721 tcggggtcag aaagtgttgt ccagtcactc gcgcacaact tggagatttt tgcggcaaaa 21781 tcgtccatgt ccttgcaaat cagcagcaaa cggtagccgt agtgactacg gcccgtattt 21841 gccgtaaagc tgaggctttc caatgtcggg agttcctcca caggcttgct ggtccacttc 21901 tgaaagcgga gcagcaggct gagcaagctc tccttgcttt tagcggataa agcgatagcc 21961 tgaactcctt cgtctggctt gggaggctgt atgaatggcg cttcctctac tacgaggtgc 22021 acattggttc cactcatccc aaacgaactg attccagccc ggcgcacgct ttgctctggt 22081 tcccactctg tcaatgtgtc atggatataa atgggagatt gttcaaaagg aatcatccga 22141 ttcgcgcgct gaaagtgcaa atgtggaggt atctgctttt gtttaagtga caggattacc 22201 ttgaaaagac cagccatacc cgctacgtgg tcggtgtgac cgatgttcgt ctttacggag 22261 ccgatcccgc aaaattggcg ccggtttgtg tatgggcgaa acgctctctc cagcccgtcc 22321 atctccatcg gatcgcccag cttggtacct atgctgtgca cctcgatata ggaaagggtt 22381 tcgggatcaa tctgcgcgtc tttccatgcc tgctgaatca cttcggcttg tgccaatgaa 22441 tttggcgctg taagaccgaa agaatggccg tcttgattgg cggcgctccc cttgataacg 22501 gcataaatcg aatccccgtc tgcaagggcc tttgtcaacg gtttcagcaa aacggcgcca 22561 acaccttcac cgacacccgt accgtctgaa tcattgtcaa aagggcgagt acgcccagat 22621 tgtgataaaa tccccaaatc attgcttcca tcttgtaagg acatcaagat gagcttgaca 22681 ccgccggcca gcgccatctc acattctcct cgacgaatcg cttggcatgc cagatgaaca 22741 gccatcagcg acgaggagca cgaagtatcc acaagcatgc tcggaccttt gagatccaac 22801 aggtaggaga tgcgagaagc gatcaccgat ttcatattgc caatgattga ggtggacagt 22861 gcatctggtt ccagctcccg aatcattcgt ttatactctt caccaaaatc actgctaaac 22921 cccagataaa cacccgtacg gctacccgcg agcatcgttc caccatatcc agcgtcctca 22981 atcgcttccc agcatgtcag caaaaataag cgctggtttg ggtccatctg gctggcttcc 23041 ttaggagaaa gaccgaagaa ttgaggatcg aatttatcaa tttcattcag gtaggcagct 23101 tctcgaaatt gaatttgttc catcgtcaac cctttggcga gtaacaatgg aatcaaatcg 23161 ttctggcgct ctttgggaag ctctcgcacg caatcttgac cagcttgcaa cagacgccaa 23221 aagtctgccg ggttttctgc gcttccgaat cggcaagcag caccaatcac cgcaatatcg 23281 tgttgattgg gtttgctgtc tgttgaatga gcatccgtct gctgtttatt cagtttgact 23341 cggttcagtc ctaatggctt gctcactgca ttcttcctcc ttgggtcctc tgctcacctg 23401 gttcggctta gcttgcctgc cattcgttgc tgatctcagg aaatcgctgt tgcaggtctg 23461 gtttgctggt cagctgttca aagcgcatgg cttgttcggc gtcaggagct ttttttgttt 23521 gcaagatcaa acgaagcaga gaaacggctt cgcgtacttc cccatagccc ccctcttttt 23581 ctccttgttc cagctgttgc ctcagttgtt gaagagcttg atagggagcg atcacccctc 23641 gctggtacgc ttcttcatcg agaccgcggt ttttcgtgca aacggcaatc gcaatgcaag 23701 aatcgaccag ttgggcaatg actgcttgat tacgcgtttt agcatcctga agctcttgct 23761 gataacgatt gatctccccc tgcctgtcaa aggcaaaggc gcgaagggga tatcctttgg 23821 ccaaatttgt cagcacattt ttgggaccga gctcaattac ggtattcgct ccctgtttta 23881 ccaagtaatc catcgtagat tgccagcgaa cagggctaat tgtctgggct gtgagcaaat 23941 cgacaagttg atcagcatgg acatatggtt gtgctgtcac attggaaatc acaggccatt 24001 tggggtcaca atacgtatac cgcttcaatt cttcatttaa ttgttcggct gcttgcacca 24061 tgaatggcga atggaaaggc gcactcacct tgaggctgac aacggaagtc gagccatgct 24121 gcttgcacgc ttcttctact tgccgcaccg catgtgcatg tccggagatg acgatctgat 24181 cagcggagtt atggttggcg accacgacga tcgcaccgtc acgagaatgt tcccgacaaa 24241 tctcctcgac aagttgagca ttcaacccga agattgctga catggctccg actccctgcg 24301 gcgtagccgc ctgcatgaac tgacctcggc gatagacaag gcggacggca tctgcaaact 24361 ggatagcacc cgcacaagtc agggccgtaa actcgcccag actgtgacca gccacccatt 24421 gtggttcgat gtccatttcc tgtgaataaa cacggaaggc tgcgacactt gccgtcagga 24481 ttgctggctg tgcgtgctct gttttggtca gttcttgtac atcccctgca aaacaaagtg 24541 tttgcagatt aaaaccaagt gcatcacttg cttcttcaaa ggtgcgggcc gcaatgggat 24601 gggcctcaca taatgcttgg cccattccaa catattggga accttgtccc gggaataaga 24661 gtgcgatttt gtccattttt gatcaccttt ctctacgtca tatattcatt cactagcatc 24721 ctgagcaatt gctggtaatc ctgcgtcatc tccgtgactt tttctgcccg gaggcaatcc 24781 gggtcgaatg cacacacgat gtcaatcacg tcttttcctt ccttgatcca gaaggtaagc 24841 tcatgttcat ggtgtgtgaa cgatgtatct ataaactcat tgacactgcc gaagaatgga 24901 atgatggttc tgtcgttgcg atccgtccgc aattttttca gccacaccga ggcttccccc 24961 gtcatgttct cgatgaactg tcgtttttgc tgcacctgct tgaatagatc gaagaaggta 25021 ttgacctctg acatgttcac gcggaatgga taggcattca tctgcagctc cttggcgaca 25081 gccacttcca tataaagatc ctgctgtcct gtcaattccg ccatgaggta tagatacatc 25141 gaaagcagaa cgtctctgac ctcaacagcc tccatttggc ttacctgctg cacattttca 25201 aacagatcat cagtaactga gaattgaacc cagtttatgt ccgcattcgc ttctccactt 25261 gcccaatact gaggcggcaa ctctatcagc gaaacaccat ccaactcctt caaccagtgt 25321 gtggtcgtat cggtttcctc ttgttcatct cccaagtcta aagcggtatt cttcaaaaag 25381 ttggttagac caaacagcgt aggatgggcg aacaaatcag caatccgaac ccgtccaggg 25441 taaagctctt caaacttggc atgaacttgc accagtaaaa gcgaattccc gcctatttgg 25501 aagaagttat cctgcatacc gaccgtttca cgtttcagca cttcccgcca gatgcctgcc 25561 acctgttctt cgagtctggt agccggggct tgatattcgg tgtgcttgtc ttggagagca 25621 tcaggctctg gcaatgattt gcgatccagt tttccgtttg gtgtcagcgg ccacatactc 25681 atatgcgtat agaaatgtgg aatcatgtaa tcgggtaaac ttttgctcag aatcgctcgc 25741 aattcatcac tgtccaacgt ttgcggtcct atatagtagg cagccaggta aggattgctg 25801 gcggtatctc gcacactgac caccgcttcc gtaatatgcg gatgctgaca tagagcagtt 25861 tcaatctcac ccaattcgat tcgatacccg cgtactttac actgaaagtc agatcgtccc 25921 acgtattcaa tacgcccatc cggcagccat ctcgcgagat cacctgtttt gtacatacgt 25981 tgaccaggtt gaaacggatt aggaatatag cgctcagccg tcagtgttgg ctgatcaaag 26041 tatcctctcg tgaccccatc tcctgcaatg taaagatcgc cagtgatctt tatcggctgt 26101 agttgcagat gctcatcgag gatgtagact tgtgtattgg gcaacggcgc accaatcgtt 26161 acttcctctg cgtcggtcaa gtcctgcacc gtagaccaaa tcgttgtttc agtcggaccg 26221 tacagattgt aaagtctcgc cttggtcttt gtgcgaagcc gttggaacaa agacgctgaa 26281 agggcttctc ctccaatcag aatcgctttc aggcagtcaa gtgcatgcaa gttgctcttc 26341 tcttccagca tgagctgtag acgggatgga gtcagttgaa ggaacgtgat ttcttcctgc 26401 aaaatcaact ccttgagcac ctgcgggtct gcttgctgct gttcggttgc aataaccacg 26461 gtcatccctt tcgtcagcgg tacaatcgtt tcaagcagaa aaatatcaaa cgaaatcgtc 26521 gtcacagcaa gcattttgtc tgcgctggca aaatcgatgt gtttcccgat ccctgagcag 26581 aagttcatca aattgccatg ctcaaccata acgcctttag gcttgcctgt agaacccgat 26641 gtgtaaatga cataggcgag atcgccaggt gaagcctgtg acggaagatt cgagttgtct 26701 tccatctcca accgagaatc gtttacgtcc agtcggacaa cacttcccca ctgcttctca 26761 gccagagaat cgtgggttaa gacgaggcga gccatgctgt tttccaaaac ataggagata 26821 cgttcttctg gatagtgcgg atcaatcgga acaaacgcgg cccccgcttt caagatcgcc 26881 aagagtccaa ccatcatttc cacagagcga ttcgtcaaaa ggcccacgca ggtatcagca 26941 gtaacgcctt gttgcttgat caaacgggct acttggtttg cttgcttatt taattttgca 27001 taagtgactt tctcatctcc gcatgataca gctatcgcgt ttggctgagt ttccgctact 27061 tcctcaaaga gctggacgac tgttttttca cgagagtatt ccaaactcgt gtcattccat 27121 tgctcaatca gcagcaagcg ctcttctgct gccagcatgg atatcttgcc gatcaactgt 27181 tcaggatctt ccaccatctg ctccagaatc ttctggaagt gtgtggacat cgacgcgatc 27241 gtctctttgc tgaacagctt gttgctgtat tcgatatcga caatcaggcg ctgttctcgc 27301 tcaatgatgt caaaggtcag atcaaactgg gcagagcgct gttcaaaagg ataaggagag 27361 agcgtcaacc cattcgcact catgcttccc ttcgcgtcgc cggtattttg caaaatgaac 27421 atcacatcaa acagcgggtt tcgcgccgta tctttcggca gcatcagacg atccaccagc 27481 atttcgaacg gatagtcggc atgagagagc gcagccaatg cccgttcctt tacttcttga 27541 aggaaatccg ccacagttcg atcgcttcgc gggaagtttc tcatcgccag tgtgttcaga 27601 aagacaccca cgatgttttc caggtctgca tgatgacggc cagccactgg cgatccaatg 27661 ataatgtctt cttcgccagc gtatttcgac aacataatgg tgagcgctcc cagtaacgtc 27721 atgtacaggg tcgccccatt gttttttgcc aatgccagta tcttctctgt catctcttga 27781 gaaatctcaa aggtcaggac atctccctcg aagctctgaa cggaaggtcg aggatggtct 27841 gtaggcagat taagcacagg aagttctcca tccagctctc cctgccagaa cttctcctga 27901 gcggccaata ccccattggc aagttgttct gtttgccaca cgctgtagtc tttatattga 27961 atccgcagct cgggcaactt gagtccctga tacaattgga agaactcgcg gatcaaaatg 28021 ttgatggata caccatcgga aacaatgtga tgcatatcga acagcaacaa gtgtttgttg 28081 acatcaatgc gaatgagcat accgcgaaca agcggcgctt ttgacaagtc aaacggttgg 28141 atgaattgtt cgaccgttct cttggcctcg ttctcgtcga cttcactata cgccaacgta 28201 aaatctacgc tcggttgaac ggtttgcatt aaagctccat ccacgatgga aaatgaggtg 28261 cgcaacgact catgacgctg aaccagcgag acaaatgcac gttcgaatgc ctctctgtcc 28321 agttctcctt caagcatcat gactgtaggg atattgtagg caactgcccc ttcctgcatt 28381 tgttccagca cataaattct ctgctgagac gaggtggcgg ggtaagcatc ccgatgctct 28441 gctacaggaa tcgctgacac agctgtttct acattcggag ccatcaacat agccaattga 28501 cgaatcgtcg gtgtctgaaa caggtcggtg atcgtcatct ctttttgcaa ctgcttggtg 28561 acacgggaaa cgataccgat tgccaaaaga gaatcgccac ccagtctgaa aaagtcgtcg 28621 tcgatgctca attcggtgta acccagtaca tcagaccaaa tttgacctaa ggcaagctcc 28681 aacgacgtgt agtgatcgcc ttcctccctg ccagacaaaa taacacggtt ttgcatggtc 28741 actgcgggtg gtgcttcgcg ttctttatga gacattccgc ttgcaaatat cgaatctccg 28801 agctttactt tcagagacgg tgcccattcc ttcagcactt gcaaatcaaa ctggccaatg 28861 atcaggtgct cagtatggca agacagcgat gcatcgaaag cttgaatggc tccatccatc 28921 ggcatgtatc cgataaaacc aggacctgtt atcccttcaa acgcatacca gttcaaagcg 28981 atcgttggtt ttcccgttcg actgcgagct gcactatagg catccaggaa gcagttggac 29041 gagacatagt cactcccagt cgctccaccc caaatcgaag caagtgatga gaagatcaca 29101 aagaaatcca aatgctccgg ttcagctatc tgatcgagta tgactgtgcc tgccatcttc 29161 gctttcaaac cattttgaaa atgagtaaac gtcttcgtct gaatcgtctc gaaggtgata 29221 tgcgccgcgg attgaataat gccgttaatc ggtccgtaac gggctcggac ttgcttggaa 29281 atatcctcca tctgctgacg gttggacacg tcggctgcgt agcaggctac ctgcgctccc 29341 atttcctcta gctcaagcag cgctttcagc tttcgtgcct cagcagaact gcagtctgga 29401 tgctgtaaac gctcttgcca ctcgtggtta ggtggaagtg gcgaacgatt aatcagcacg 29461 agcgtcacat ttttttgagc ggccagatgc ttactaaatg ccagtcccag ttttcctgta 29521 cctccggcga tcaagtaaac gccattttcg cgtatctcta ccggtcgctt cggaatttta 29581 tcgatatcgc agcgattcat ctctggtaca atgcgatttc ctctataggc aaccaatgtg 29641 tcatcccgat tgcagcgaat ttccgctaga agctgaccag ccaattgcga tacggacagc 29701 ccctctgttg cgagatccag gctaaagcat tgcagttttg gattttcctg cgagataacc 29761 ttggctagac caaacaaggg ggctttttca ggatagacag gtccattgtc atccactgct 29821 tgtgcgtagt tcgagacgat ccgtaaatca agcacctgct tcagatccag ctcaagcaac 29881 gcttgtgtca aatgaaacag actgtaaact cccaggtgtt gcgctgattc aagagcttca 29941 agctgtccga gatcatttgg ctgttgggca cccgaggtca agctccataa atggataatt 30001 ccagtcagat tttccttttt ctctccgagt ctctcgaaca cacgccgcag atctgccggc 30061 tggccgggat ctaggataaa ctcgtgagaa gaaacggagg caaaagcctc accgctgcgc 30121 agtctgaaca cttcatgtcc ttccgatgac atcgcgtcag ccagcgtttc tcctacaccg 30181 ccttcatctt gaagcactaa ccagatccct ggacgctggt tttgaggatt ggttgtcagc 30241 tcttttgttt gccaatggat ctggtagagc cactcccgat actcttgtgg cgtatatgct 30301 gaatgtccga tcaataaggc tgaatcagag agatcaccca gcgctgttga cgacggataa 30361 atggcaaccg attgatagtt cgtatctcga agcgcctttt cccaacgtaa ggcatccatc 30421 agtctggttt gcggtcgcag atcggtgtct tcgtgctgcc accagtctgc ggcaagcccc 30481 ccgatcacat ttgccgttga acgatttttc acgagctcga tcgcaaacag cacgccttgc 30541 tctgcaagca actgatgcaa aatcgataag gatgcccgaa catccttcga cctgtgtata 30601 gcgttattag caatgatcac atcgtatgcg tgtagatcga agccttgttc ggctggggcc 30661 agctccatgt tgaacggacg gaactgcaca aacgggtaca cttcttggaa ctgtttttct 30721 gcctctacga gagacgattg cgcaccatcc gtaaacagat agctgacatc ttgtttcgca 30781 atcttcggca gcaataagcg agtaagactg ctggaaccgc ccccgagctc caaaatgcga 30841 acaggacggc taaacgaatg gatgtattgg gcaattgttt ccactaccac aagtccagaa 30901 gggtttccaa gagtaatgcg atccgtatat gacttatata agtcagacgt accgtcgttc 30961 gacacgagta cgttctgccc cgacatgatt gttgagtagt gggcaaaaca cgctttcaat 31021 tgagagaacg tatctcgctc attcggatag cgatccagac aatcctgata aaacacttcc 31081 gtatcaagac cctctgcatg cgcagataga cggtatgttc cttcaatgtg ttcaaccaga 31141 gaggccttac caacaagttc aagcatgagt tggaagatat gttcatttct tccatcaaac 31201 ctgacagctt cacgcaattc ttccagcgta tacgtttgat cctgcttatg gaacacacct 31261 agtttcttga agcattcaag cgatgacaag cccgaataaa aagtttcatc ctcttccaga 31321 cccatttgct ttttgacatt cacctgattc agtaaggttt ccccaaaagt aaagaaggtg 31381 gaagcaattt tatgcacatc agctgtttcg ttctcatgag ccgcttcaga tgctacagca 31441 gtggaccgct caaccgtgtc gtttgcaggt tgatccgatt gcacccagtg acgggttttg 31501 gcaaaggaat aggttggcaa aggtaccttt ttccatttga caggacggta gtattcaagc 31561 caattgatag gcacccctgt cacgtactgt tttgccattt ctactggatc agagctgtcc 31621 atttgcacgc tgatcggcaa tgagctttcc ccacgggaat tcaactcccc gtagaacacc 31681 cgattttcat caacgagcgg ggcgccatcc tgcgttcgtt ctcccacgca caggcgatta 31741 atctgctgca aaaagtcctc tttgttgttg ataatgaacg caaggcgata ccgatagtgt 31801 ccgcgcccaa tattggcagt agcacacata tcaagaaggg aatgctcaga aggcgctgat 31861 aaaaatcctt gatatttctc gagcaaatcc catagtgact cacttgtttt ggcagataac 31921 gcaatgaggt aatcgccaga ttctgaaatg gctgtcgcct cgcgcccagg gggctcttcc 31981 aatatgacgt gggcgtttgt cccgctcaga ccgaatgcgc ttacgccggc tctcctcacg 32041 ggttggtccg cctctacatc ccaagccttt agcacatcat ttatataaac aggcgaatca 32101 ataaaaggaa tcaaggtatt cggtcgtttc acatgcagcg tcggcggaat ctggcgatgc 32161 ttcatcatca gaaccgtttt aatgatcccg gccacgcctg atgccgctat cgtgtgcccg 32221 atattgcttt tgaccgagcc tattgcgcaa aattgcttgc gttttgaaac tttctgaaag 32281 gcatgcatga tcccctcaat ctcaacaggg tcgcctaatc ttgtcccggt tccatgtgcc 32341 tcaatatagg agatgctctc cggattaatt cgcgcccgct cccacgttgt tcgcaacaaa 32401 gcagactgag aaatcgcatt gggcgctgta atactggtag aacgaccatc acaattgacc 32461 gcagtgcttt tgatcaccgc atggatgtaa tcgttgtcct tgactgcttg ttcgtaggat 32521 ttcaaaagaa cagcgccaag accttctccc catactgttc catcagcaaa gtcatcaaat 32581 gctttggttt ttcgttctac agaaacgatg ccaaagtctg tatcttgttg aatcggaaac 32641 aaggaaaggt taactccgcc tacgagagcc attcgacaat cgttatttcc aatggcctga 32701 cacgcttgat gcagagcgac caaggaggaa gagcaagatg tattaatcag ttggctcgga 32761 cctgacagat tcagcaaata ggaaattcgt gaagcgataa ttgctgcaac gttgccagcc 32821 agcgaagacg aatcaacgtt tttcaacaca cgctggtatt gtgattcatt gtcacaatat 32881 cccagaaata cgcctgtagg agaaccgctg atcatcttct cgctataccc ggcatgttca 32941 aatgtttccc atgccaactc gagaaacatc cgctgataag gatccatggt tcgagcctct 33001 gcaggtgaga tctcgaaaaa cgcatgatca aataaatcca cgtgatcgag ataacccatc 33061 cgctcatact taaaatcttt gccgttaaaa aattctctcg ctaccctctc gacgtctgga 33121 cgccttgcag cagggatatc accgattgaa tcgtgcccct gtttcaaatt attccagtat 33181 tcttcgaggc tgttagctcc gggaaaacga caagccatac cgatgatcgc gatatcttgg 33241 cgtgtattta cgttggcaga ggacagttct ttcagcaaag gaagtgcttc cttctcttgc 33301 agtcgatgag ccgccacttg ctccaagatg tattttttta gcaaactcat cctatttccc 33361 cttcctttta tcgatcagtt cggcaccctt gtctacggag agaactccct ccttgacctc 33421 cctcagtaat tccagaaggg attcatcatc atcgctttgc tcttccatag atgcaaactg 33481 gtcctgtttt ctttgttcga gaaaatccac aaacatggca atcgtatagt aggaaaacaa 33541 atgcgcgacg cttatctcgc tatccacttg ttttacaatt tgcgcatgca ttttaagcag 33601 cagcagggaa ttccctccca gctggaaaaa gctgtcgtgt actcccactt tttcgattcc 33661 caagatttct ttccagatgg taaccagctg ttcttccttc tcatttcgtg gagctacata 33721 ttcagcatcg gacgcctgtt gctcatccac tttaggcagt agcttgcgat tgatcttgcc 33781 ccctgctgtt aaaggcattt tttcaatgct gacaaaaaag gatgggatca tgtgatcggg 33841 aagccgttcg ctgagataac cacgcaagtc acttgcggtc aattcctgag cattcgatac 33901 gtagtacgcg cacaatcgag ccttctcttc ttgaaatagg acagcacact ctttaactag 33961 tgggtgggac aatagaacct catcaatctc gcccagctca attcggtgcc cgcgtacttt 34021 tacttgatga tcgatgcgat cgcagaactt gatattgcca ttcggcagat aacgcccaag 34081 gtcgcctgtc cgataaagct tttgataacc aatttccgga taagggttgt caacaaagct 34141 ggctgctgtt ttctcaggat cgtgcaagta accgtgccct aagcacaagc cagttatata 34201 aatctcccct tgatgtccca ccggaacaag tttgcgattt gaatccagca gcaaaatttt 34261 cgtattggct atcggctttc caatcggtat ctgtccctca tgggtatggt cgatctcaaa 34321 atagatgaca ccaatagacg tctccgttgg gccgtacaga ttcgtgatac gaacgtgggg 34381 aaaccgctgt agaaacaaat gcacggtgtg agccgtgatt tcctctcccc ccaagatcag 34441 gtggcgaatc gcagaaagtg aatcgtgtat atccatccgt gtttccattt gatccaccag 34501 caggttaaag accgacggca caaagtccgt aattgtaatc tgataggtcg aaatagcgtg 34561 cagcacttga tcgagcgtca tctcgaattc aggaatcggc agtaccgtac ggccaccatg 34621 caagagcggc cagaaaagtt gccagaccga actgtcgtag tgatggggag tcgtctggaa 34681 aatggcgtcc tgttccgtgc aaccgtaatg ttcatccatc cagcgaaacc gattgaaaat 34741 accgatatga ggaacgactg ctccttttgg tttgccagtg gaaccagatg tatagatcac 34801 atagatcgga tcgtccacat ttacctggac atttaagtcc ccttcttccc ggatatcgtc 34861 cgcatcgacg attacagcac gtgtcaattg cacgaatgac ggttcctggc gtatttctgg 34921 cccgatcagc gtcaccggac aatccaattc atccagtagc tgctttttcc gttcagtcgg 34981 actttgcacg tctagcggga caaatgccgc acctgttttc atcacagcta gcagggaaat 35041 gaccaaattc aagctacgat tcatcaagac cggaacatag cttcctcttc caatgccact 35101 ctcctttaac atgtgtgcaa ggcaattggc tttcccatta agttgaccgt aggtaagggt 35161 attgttgcca aacacagctg ctgttaaatg aggcgtccgc gctgcctgtt cctcgatcag 35221 ttgatggatc ggcttggggg cagaatgagg aacgtctgtt tgattgcggg tgtacaacag 35281 atcagtccgc tctgcttctg tcaacatatc gattgtgtgc accaaccgtt taggatcgac 35341 gaccacttca cgaagaattt gttgataatg gctgatcatc cgttcgatga cagcctcttg 35401 gaactgctcg cccgcatacc gtacgcgtcc ggtaattcca tcttctgttt gcttgaatgc 35461 aaataccact tgcagggaca ggccttctaa agcagcaata tcttgcatgt tttctagtac 35521 gaaggctgta tccagcagtg tcttcaggtc cgtgtcggat agatcaagcc attgcatcat 35581 ttgcgaaaac ggatagttct gatgctccat tgcctctttg accagctgct taccctcttt 35641 cgccacgtct gcaaaagtag cttcttgatg catccgtaca cgcagcggca gcacccgatt 35701 ccaagcatta gggggaagcg gattctgaaa gaccggcgtg agaatgatca tgtcgtctgt 35761 ctgcttatac cgattcagca tgatttgata cgtcgacaga aggaacaggt agagcttcat 35821 cggatgatga tcgcaatggg ccgtaacggc agcgttcaaa tcatccggaa ggacaaaaga 35881 tatttctttt gtctcctcct ccccatcgcc ttccttctcc gtcccttcgg ttggaaggag 35941 ggagagcgtc cactccccct gtaacttctc ttgccagtac tgctcctccc ggctaaattt 36001 ccgactggtt agcagaatgt tttgcgaaat agtagtctcc atattgccct ccccctctta 36061 cttaccgctt gctctaaaat tcaaaatccc aatcgacgcc ctgtgcttga ataagggcta 36121 cctcaagggt caattcaaag tcttgcagga ggcgcagggg atcttccatc aactgctgca 36181 acaagctttt gaagtcactc acaaactgct ccatcgtctc tctgcggaac aggtcactgc 36241 ggtaatccag cttacatgta agtctgtcga aaacaggata agccgacaga tgaaggtcaa 36301 gtttagccgt gttgttttgc agtggatagt ttttgacgat catgtcctca agctccagtt 36361 ccccttccgg attgtccatg ttttgcagga cgaagatcgt atcaaaaagg ggctgacgac 36421 ctgtatttgg ctcaagccca agagtctgga caaacagatc aatcgggtaa tccgcttgtt 36481 caaaagaggc tagcgtatgc tcgcggacct ccgcaagaaa ctcgcgatag gttttctcgc 36541 cttttggata attgcgcaag ggaatcgtgt tgataaacat cccaatcact tcatcaaact 36601 ctgcaaattt acggccagct actggagttc cgacaacgac atcctcttga ccgctgtatt 36661 ttgcaagcaa catgttgtaa accgacaaca gcaccatgta aagtgtcgca tgttcctgcg 36721 ttgccagctc ctgcaaccgc tgcctctcct ccgccgatat atcgaactca atcgtcgcac 36781 caggatacgt aagagattct ggcctttcgt aatcagtcgg aatcgatagt agtggagccg 36841 ggctggtaaa caagtctgcc caatagtcag cttgaagctc ccctgactca agtgcagatt 36901 cttgccaaac agcaaactct ttttgctgaa cttccaatgc aggaagtgtc acgcccgcat 36961 agacacgaac aaagtcctct atgagaatat ccatggatac accgtctgaa acgatatggt 37021 gcatgtcgaa catcaagaga tgcttttccg gtgcaatcct gattagccct gcacgcaaca 37081 agggggattg acgcaagtcg aatggccgta caaacgttgc cagactgacc tccaactgct 37141 ctgcacttgc ttcgctcact tccaaatgga agaccagcga atcatgtaca atttgaacca 37201 cttgcccatc tatataatcg aacgaggtac gaagagattc atggcggtca accagtcctt 37261 gaaaagcttg ctctaccttc tcacggctca aagctccctc gatgaaacgg gcagccgtaa 37321 tgtgtagact tgtgtcagcc ggattgacct gctgaagaat aaagaacttg cgctgggcag 37381 gcgtaacagg atagtacgat ctggcttcga cagggaaacg tcttttcata atcgtcttgt 37441 ctgctccatc aatcaccttg ccaagctcct gaatcgttgg gtgattaaac atggttcgca 37501 gtggaagctg tacgccaaac tgttgagcaa tctgcgcagc caccgtattg atttttaacg 37561 aatgcccacc tagagcaaag aaattgtccc gagcgctgat tgtgtttgga tcaagctgta 37621 acacatgccc ccagatttgg gtgagagctt tttccgtctc ggttgtagct gacacaaaaa 37681 tagatgtgtc gacccgatcc tgtatgccag gcttcggtaa agcccctctg tccacttttc 37741 cgttaggggt aagtggcaat acgttttgtt ttacatagtg catcggcacc atgtattccg 37801 gaagcacagt aaacagataa tcacgcacat ctcgtgcgga aaattcctct aagggaacga 37861 cataggcaca taagtacttt gcacccgttt cctctgaaag cgccaagacc actgcgtcct 37921 taaccgctgg atgtctgcgc atcacctgtt caatctcact caattcgatt cggtaacccc 37981 gaatcttgac ttgattgtcc attctcccga agtactcaat atatccgtcc tccgtgatcc 38041 ggccgacatc acctgttcgg tagaggactt ggtaatcagg gtcttctacc cagctggcat 38101 acggatttgc tacaaaaact ttctgtgtcc gttcctcatc tttgtagtag ccgtatccaa 38161 cccccggacc ggctacacat atttctcctt ttacgcctcg cgggcagata cactgatttt 38221 gatcgagtat gtaaatatgg gtgttctgga tcggtatgcc gattggtacc actatctgtt 38281 gatcgctggg cattccccga ataatgtggt gggtaatatc atcggatgct tccgttggcc 38341 cgtacatatt caccaatgga atttccgtat agcaggcaaa ccagcgtcgt accagagggg 38401 caggcaactc ctctcctgtt actgccatcc agcgcagatc agggaagctg cgtgcggagt 38461 cgggccattc ttgaacgaga tcaagcagca cggagagcag agatggtacc acttccgcta 38521 cggtgacgcg gttggatcgc agaacattat gaagggcctg tgtatccatt accgtctctg 38581 tatcgaccac tagcacagag ccacccacta gcaaaacagc tagatattgc caaacagaaa 38641 tgtcgaagca aagagaagcc gtttgtgcaa caagatcatc ctcgcagagg gataggtcgt 38701 tgattttagc gaaaatgtgg ttaatcattc cacgatggtg caccattacg cctttcggtt 38761 gtccagtcgt gcccgatgtg aagatgatat atgccaagtc tgttcccgca ctctcccgat 38821 cgatgtcttc tcccgatagc gactctactg attcgtcgga ttgaccaaag acatagagat 38881 acttcagttc aggtgaggat gcttgaatcg actccaatcc atctagcaag tcaggctgag 38941 tgattaaccc tgcaatctcg ctcttctgca cgatgtacaa gatccgatgc agcggatagt 39001 ctggatcaat cggtacgtag gctcctcccg ccttgaacac tgcaagaatc gcaacaagcg 39061 tatccacgtt acgcttcata tagataccga tttttgtgcc aggtcgtaat ccttgctgga 39121 taaaatggcg cgcaagtcgg ttggatcgct cgtttaattc ctgataggtt aaagttgatt 39181 ttccgtctgt caccgcttta cgatgaggcg tcttctttac ctgctcctca aagaggcgat 39241 caaagctctg atcgcgcgga aaagcaaccc gattgtcgtt gaatgaaaga acgagctccc 39301 gaacctcttc cgtagataag cacgctatct cagcgatctt ctgattcggt tgcgttacga 39361 tgacctgata gatacggact aaatgctcca tcatccgttc catcatgggg agttggtatc 39421 tttgccccac gtaacgcaca agtaattcga ggaagttccc ctttttggaa aagaggagct 39481 gcaactcgct cgaaacctgt tccaggctgt cctgatcatg aaggacgtcc aacaagcaag 39541 tcgcctcaaa aaacggtgtg ctgttcccct gctgaggtac ttgcagttcc tcgatcaacc 39601 gcaagattgg gtagttctga tgttccacag cggcctttaa ggtctgccga acttcttgca 39661 gcagctcctt gatgctccat tccgggagta cctgatgacg caagggcagt actttgttca 39721 aaaactcacc cggcgttgtt tgacgaaaga tagccgttcc aacgcatatg tcctgatgtc 39781 ccgtgtattt ggacaacaag atgccaaatc cactcagcaa agccatgaac aaacgttgat 39841 ccgagccatt gctcagatga atcagcgcct tgctgagttc gtccggaaac atgatggtca 39901 gctcacgaag ctcagactga cgctgaaacg aggcccgaga gtctgttgga aggtcgagtg 39961 aatgaaactc tcgagaaagg ttctccatcc aatagccttt ttcgcgatca aactgcccac 40021 tggccagcaa gatgttttgt gccgttatcg ttgtcaagcc aatccctctt ttctgtccgt 40081 catgtatttc ttaaaaagca aagtcatcgt cgtccacttg tccctgtgct acttgtacta 40141 ctccatgacc gatctgaagt tgtccgatgg ttcggttcgg gtgggctacc atttgctcca 40201 gaagaatgac aaagtcttga gccatcctct cgattgttct tctgtgatac aagttcgtgt 40261 tatattgcca gtgcatgcct atgtgatcct cagccttaac cacttccaaa gccagatcga 40321 gcatggcagc tttgcgtctg aactcgtacg gagcaaactc gatttgatcg agacggacct 40381 tttgctgctc cgctgcatga tgcagggtca gcatggcgtc aaacagcggg ttccttgctg 40441 gatcacgtgg gaattgaatc tggcttacga gttgatcgaa tggatagtct ccatgctcaa 40501 aaccgctaag cacgttttgg cgtacctgcc cgatatactc ttggacggtc aattctttct 40561 tcggccagtt tcgcaaggcc aaggtgttaa caaacattcc cacaacaggg gcaaactccg 40621 cacgttgtct accatccatg tcgcagccga cgacgatgtc ttcctgattg ctgtatctgg 40681 ataacaaaac agaataggcg gccaaaagaa gcatgtacaa cgtcgtagaa ctctgacggg 40741 tgaacgagtc gagtttttcc agccattctc cagacagctc agtcagcaac tcatctccat 40801 caaatgtcat ggtttgtggg cgaggataat cggtcgggat tgccaacggt tgcggctgcc 40861 cggaaaaggc gtccaaccag taggcttcat gctcggccca gccgatctcg gcagcttgtt 40921 ctctttgcca ccaagcgaat tccttggcct gtaccgacaa ttccggcaaa acctgtcctt 40981 ggtagaggta acaaaactcc tcaagcaaga tggacttgga tatgccatcg gaaatgatat 41041 ggtgcatgtc gaaaatcaac agatggtctt ctgatgagag ctcaattaag ccgatacgaa 41101 gcaagggagc ttgctttaaa tcgaatgacc ggaaaaagcg ctcgattgtc ttttccacag 41161 cttcctcgtc tgttttccat gtctcgatca gtacagacag gtcactgtgt actttttgtt 41221 tcacctgacc ttccattaga tgaaacgagg tgcgcagcgc ctcatgtcgt gcgacgagtt 41281 gatccgcaac gtcttgaaga cgccctgaat caagggaacc ggtgatccgc ataactcccg 41341 gtgtatgata gctggtagca tcttcttcca actgccacaa caggtaaagc cgctcttgcg 41401 cacgcgtgac agggtaatat tcctgatcag agagcaaagc gatcggtttt tgctccatct 41461 cttggaggct gcctgtgatc ctattcgcca aaccacgaat cgtcggggca tcaaacaggt 41521 cgcgcatgga aagcttcact tgaaagtcac tttccactct ggataaaagc tgaatggcct 41581 tcagcgaatg tcctccatgt ccaacaaagt gatcaagtac accaggcgat ggaatctgta 41641 aaacatccgc ccacaactca gccagctttt gttcgatggg attttccggt gatacgtatt 41701 cactactgac gcttggcttt acagcaggca aagctttgcg atcgatcttt ccatgcgggg 41761 taagcggcat ctcggacagg tccataaagt aactcggaat catatattcg gggagccact 41821 ccagcaggtg cgcacgaagc ccatctggct gaacgccatc cttttgcact acatagtagc 41881 aagccagttc gatcaacccc atctgatcag tcatagccaa tacagctacc tgattcacag 41941 caggatgctg aaggacggca cgctcaactt ctttcagttc cacacgataa ccacgcactt 42001 gaacctgatc gtccatccgc cccagatatt caaacactcc cgtttcgctg atcaatccga 42061 catctccagt acggtaaagg cgctcgccgg taatgggatg atacgtaaaa gctttctcgg 42121 tcaactcagg cttgcccaaa tatccgtcag tgatgccaat tcctccgata caaatctcgc 42181 ccttgacatc agggggacaa atttctcctg tctggccaag gatgtacata tgcgtattgg 42241 caattggcac accaataggg attctgagtg tttcttcagc aggctgttct gtgcaaagat 42301 agacggaagc gtatatcgct gattctgtca tcccgtaaat attggcgatt cgcgcgacac 42361 ggaacagacg attccattcg cgaaccagat tagctgtcag tgcttctcct ccattaaata 42421 cccacttcaa gttgggcaac ggatctgttt cattacgaga atgcacatga gccagaaaca 42481 cattcatcat cgttggaacg aactgggtga ctgtaatgcg ttgctcccgc agccagtcat 42541 acaacgctcc cggatctttg ccgtcttcct ctttcaaaat agacagcttt gatccaacca 42601 tcagcggcca aaacaattcc cacaccgagt ccgtaaaaga aatcgaggtt ttttgggcaa 42661 ccacgtctgt ctcgctcagt ggaaaagtct cctccagcca aaacaatgta tttaatacct 42721 gtttgtgcgt aatcatgaca cccttcggtg cgccggtcga accagatgtg tagatgacat 42781 acgcaacatc aacctctgaa cctgccgggg ctaatatctc atccttttgg cggcgaatgt 42841 ccgacgctgt atagaccttg tatccttcgt gatggaagga agtctcgtcc aaacaaatga 42901 tcgtttcgat gctgtcaggg agatccggta tgatctcatc cagatatatg gattctgtta 42961 caagcacctt gcagcgacta tcctgcaaaa gataccgaat tctagctcgg ggataatgcg 43021 gatcaaccgg gacgtatccc ccacctgctt ggaggattgc aagaactgcc gctaccatac 43081 gggaactcct gtctgcgaga attcctacga gttgcgaagg aactacaccc gcatctttca 43141 ggatacgggc tagctggttt gcttccgcgt gcagttctgc gtatgttctt tctcgatccg 43201 cctcaaccac agcgactcta tcaggcgttt tttccgcttg ccgggcgaac agttcagcga 43261 ttgtcacttt gttgcgatac ggtttgtctg tctgattgac tcggcttaac aagttcgctt 43321 catcatcagt gagcaggtta aactcattca gatccagatc gagctccata cgtccattca 43381 ttgcgactct tccccttttt aggtggtggt gaaaaattcc cgcaaacggt taattccctc 43441 gttatacttc gcggcagagt atgagaggcg cagtgtgttc gagatgccaa agtctgaacc 43501 cggtacggtc gccacatgtg tcgcctcgaa aatttgcgta gccaactcaa gtgaggtgct 43561 gatgcctttt ctcttcataa atgcttcgca atcaatcgtg aagtagaagc tgcctctcgc 43621 tggcagagca cgcacatccg gtacattttg gaaagcgtca atcgtgtagt cccgacgacc 43681 tttgtacagt tggaccaaat gatcaacctc atgctggtaa tcaagcgcag tcattgctcc 43741 gaactgtacg actgggtcag ctgtgagcag tgtgtggtgc tgaataaccg tcaatggctg 43801 tacgagctca tctggtacga tcgcatatcc gacacgtctg ctatacatcc gatacgcttt 43861 ggaaaacgca tctgttgtga tgaaggtaga cttggtattt ttcagctgca ttacggattc 43921 gcactcgtca tcgaagtacg tattcgcata aatctcgtca ttgataatag ccgcacggcc 43981 gtctacgatg ctgtcgatcg tatacaattc ctcttttgta agaatatttc ccaacgggtt 44041 gccaggcgtg ttgatcacga ccaccttcgt cttgtctgtg aaattctctt taaacgactc 44101 cacatcaagt ctcaacgtat ccagatcaat tttgtaataa cgaactttcg caccgactag 44161 cagcgcgcag aaatggtaaa gcgagtagta cggaagtggc agcaacactt catcgccctc 44221 tttaagcagg aggtagaaca ggttacggaa gagtgtgctg gtaccgacac tgattacgaa 44281 attctccggt ttgattgaca catcgtattt tgttttatag tgggtcgcga gcttctcttt 44341 cagctccggc agaccacctg gatatacgag cgaatatttt tcaaagctgt tcaatgcctg 44401 ttgcatagaa ttgataattt cgggatgcag cggcatttct gacttcccaa gagtcatgcg 44461 gatcgcttct ccaccgtttc tctcaagctc atttgccatc tggtccagta caaacatcaa 44521 aaagcgttcg tcgtgaaaat taattgagga tctgatttcc atattctcct acccctttta 44581 ctttattttg gatttttctg ctaacatttt caggattttc acatagcgat ccgaaagcga 44641 ttcaacatat gccgtctgaa gcatagatgg atcataggta aaaacgacat ggataccttc 44701 cgaagtttct gctacctgaa gaactagcgg acttccggcc atttctggct cgaatgatcg 44761 tttcacttca cgtttccaaa cagctgactg agctttgaac ggtatcgtct ggttgacaaa 44821 aagtgtcggc cattccatgt gtgtcgtcgc ttgccagtgc tctgacggat acaacgcgag 44881 tgtttgcatt cgggcaagta cttgcttcgt ttgatccaat aattgtgaaa acgaactgat 44941 cgtctgcata tcgatggtga gcggtacaat gttgtcaaag ttccccagca tttgttccag 45001 cacatcttgc gtacgattcg tcgttactac cccaagcgtc aagctaggca attgggtgac 45061 ctgtcgaagc aacagcaggt aagaggcaag caaaatgtct cccagctcct gattggaacg 45121 agcagctaca tgcagcaaat cggcgtgacc tgtcgggtcg atatactgct cgacttgtcg 45181 cgtcgctacc cctcccgtac caaatggttg agcagaatgt ggatttgttg ctgtcaacca 45241 ctcgtgacgc tgggcctcga aatgtccgta atgaagcatt tttttctgcc aaacagcgaa 45301 tgcttcgtag cgaggctgtt catccacagc tggtgcatgc ccttctgcaa tcgcctgata 45361 tagagcctcc cattcctcca ggagaagtcc gagacctcgc caatcactta aggagctgtg 45421 aagacttcca atcaaccgat agcggtctgc agccagcttt accagttcaa atcgaaccaa 45481 acgtcctgct ttgtcctcaa acggcctctt ctgctcggca atcaatcgtt ctcgcaacga 45541 ttccgctgtc tccgcctcgc ttttctcctg taaatcacaa agcgcaagcg gaatcggttc 45601 ggataagcct tgtggcgaca gcagaggaaa tcgtcgtacg agagcttgcc atgcttgctg 45661 catatacgac agttcgattc tgctccggag ctcgatgtca aaacatctga cagccacaat 45721 cccattttct tgttcctgct tcagcaaacg ttcctgaacg aaggaataga tgggcgttgt 45781 ttccgtatga aactcgccta gaatcggctt agatctttgt gctgctgatt tcccgtcggt 45841 taaaagtagg tagggggcat ctgtcagttg cagattacgt cctgttcggt ctgcaaaaga 45901 aacggggatg ctacacgcta tcaaagtgtc gatccgttcg gtcagattcg ctacccgatc 45961 ctcgatttgg taaacaccac aaccactttt catgagctcc cgttgttctt gcgagtgctc 46021 cattcgaggc tgaactaact gaatgctgct ctcatccgct ttgcctagtg tgatgataat 46081 ggcttgcgat tgccgatcta gatatttctc gtgaacacgg tagcccagga aggtaaagaa 46141 cgacagtgcc tgttcagcat ctggtgtaag caaccggata gcagatcgct gatctctgct 46201 ttgccattcg tcatgcttca tatcctcgct ctctacaagt tcaatcaagc ctaccgattc 46261 caggaagaga aaggcaacga gtctatgatt gaaaagtact gctggcttag gagcgctgac 46321 caaatcgtat tggaagccag aatcaactaa ccttttcaaa aattgggtaa tattggaaat 46381 agaataacat aaatggtacg gacccgtccc cttctcttcc aacaaacgaa cgcaaggtga 46441 cgtttcatcg acaggcgcaa tcagctcaat tggcacacag cccggtttca tgcacatgga 46501 gagatacacg ttttgttctg gatcatgaag ggaatcactc gcatcaaatc cgagagtgcc 46561 atacatgatt tgagccggac ccagttctgg aactgcaact ccggcatgat gaaggcggtt 46621 cattacgccc tctttttctg tttggtgatg tacaatgtcg acatcatcca atcgctgttt 46681 cggatgcttc agaagcactg cgagtacacg caaatagttg tcagcaaagc cttccattgt 46741 ctccgcttta aacaactggg tatcgtattc aagcacgcac ctgaattgat cagtgagtgg 46801 tgtaatatcc agcttaaagt caagtttcga tgtcttcgat tcatgcggaa cctcttcaaa 46861 tttcacgtcg ccaagggtaa acctgacttc ttgctcacgc tggttatgga agatcagcat 46921 cgtatcaaac aatggatttt gcatttgctg gatgcctgcg gcgctacgag caacgatttc 46981 ttcaaacgga taatcctgat gttcgtaagc cagtaacaga ctgcgctgaa cctcttgtac 47041 aaaatcggta tacacaagtt cggcacgagg acgatttcga atcggaagga agttgataaa 47101 gacgccgacg attcgctcca aatcgggatg gtttcgtcca gctaccagtg aaccgacaac 47161 gaaatcttcc tgagacgtgt atttcatcaa caacacgtaa taagccgaca tcaaaacagc 47221 atggacagtc aattcgttct gcttggcaaa tgcatgcaaa tcaccgtacg tagaatcagt 47281 aatgaagaac gtatagtggt ccccctgaaa tgtcttaacg gaagggcgca gataatccag 47341 tggaaaagac atgagcggga ctcggtcgct aaaagtgtcc acccagtatt tttcctgctg 47401 attccactgc tcactacccc gctttttcca ctgccagtcg gcgtagtcct tgtattgaat 47461 aggcagtgca ggcagctctt cacccacata caacctggcg aagtcttcca ttaacacatt 47521 cagtgaaatg ccatccaaaa taatatgatg agagttgaag agtagataat gctgagtagc 47581 tgtgacctcg actaggcaaa cctgaaggag aggtgctttc gtcaaatcaa aagattgccg 47641 gaagtcttcc atcagttcgt ccaatgccct ggcgtcgcta tgaatggttt ggatctcaaa 47701 tggcactttg tcgctgatgt actgatacac ttctccatcc tgtaccgcaa acgaagtacg 47761 gaatgcttca tgcctttgga tgatttcctt acatacacgt ttcactcgac ttacatccag 47821 atgaccgttc accgcgatta cacccgacat gttgtagctg gtgctttcgc cttctatccc 47881 atgcatcacg aaaattcgtt tctgtgaaga agaagccctg tatctctcgg cttgaccgac 47941 ccgatcaatc ggcgcgtagg atatcggctg tctacccctg atgcggtccg ctaattgtcg 48001 aatggtcgga ttttggaata catccctgat cgtgatgtct gtttttcttt ctttttgcaa 48061 tctggtcaca agttgagcgg ccttcagcga gtggcctcct agcgagaaaa aatgatcgtg 48121 catgcttatt ttttcgactg ccaaaagctc tcgccatatt tgtgccaatt gctgctcaag 48181 ttcatctgcc ggggcccctt cctttcccgt gcgatactgt gtgtaatcca tacgttgcaa 48241 ggcagtcttg tctacttttc cactctgtgt tcgaggcaag gcatcaagat ggacgaaaaa 48301 ggctggtagc atatagtcag gcagataagt cagcactgct tcacgcagaa cgtgttcctc 48361 aatcggttgc atcgcaacca agcatgcaac cagataagga tcgcgctttg actcttgaat 48421 ggccactacc gctgcttccc ggacaccagg ctgacggcgc aggaccgctt caatttcctc 48481 caattcaacg cggttgccgc gaatcttgat ctggaaatcc ttgcggccaa aatattgcag 48541 atgtccttca tccgtccagc aagccaagtc tcccgtacga taaagtctgc catacggggt 48601 cattatatag gacgctctgg ttttttcctc gtcagcgatg taaccttctg ttactcccat 48661 cccgcctacg tacatttccc ctattacccc tttaggcaac agatgaaaat cttggtccag 48721 aagaaaaaca cgaacgttat aactcggatg tccaatcgga agcgggtttt caaaaggccc 48781 ttgtcgcggt acacaatacc cagatgcgga gatgctattt tccgttgggc catacaagtt 48841 gtacatctgc gcttgaggca gcaaggctgc gtgtcgttcc actaatgaag aagacagcat 48901 ctctcctgta cacaacactt tttgaatcga atccagcgag ccatcagcca cgtggtcaag 48961 caaagcgtga tacatcgtag ggacgacgag tatcacgttt gcttgttggc tttcgatggc 49021 agccgcgagc ttttgcgggg acttgttttc atggcgttgc aacaagcaaa gggtaccgcc 49081 gctgatcagt gtgcagaaaa tctcgacaac cgatgcgtca aaagtcaacg tggcgatctg 49141 caacgttctc gtctgctcgc cgaacccgac aaattcaatg tgccaccaaa gagcgttgat 49201 taattgatca tgatttacac gcacaccttt tggcgtacct gtcgaaccag aagtaaagat 49261 ggcatacgcc gtattcgaag gtgacgcttt tcgctgtggt gtttgagtta attcctgtgc 49321 ccagcatgct ggttcatcca gacgaaacac ccttgtttgc aagtctgcga cgagctccag 49381 atagctgccc tctgtcacaa tcagaacagg ctctatctgg tttacgatct ggtcgattcg 49441 cgcttttggc aagtctggat caagcgggac atagtaacac ccaactttga ggatagccag 49501 cagtgcagta atcatctcag gggaacgatc acacacgata actatcggtc gacctgcatc 49561 tgtcacctcc ttttggagag cccaagacag gcgattcgct tgctcttgta actccttgta 49621 ggtcacagac tgctttcctt gtacaagcgc aactgcatcc ggtgtttttt ctgccacttg 49681 atcaatcaac tcgtgcacgc agtagttact tggaactggc acgaccttca tctgttcctc 49741 gatcatctcg tgccgctcat gaccactgag cagggtaagg ttacgaatct cttgatccga 49801 atcagccgca atctgctcga gaaggctctg atagtgaagc gccaggcgtt cgatatcctt 49861 cgcttgaaac ttccatgcct ggtagttgac atggactgtc cattcatcac ctggtgttac 49921 ttccagcacc attggataat cggttgtttc atgtgaagtg atattctcca gctcgaagtc 49981 aagttccaat ccggccagcg tcttgtcgat aggatagttt tggaaaacga acaaactgtg 50041 cgccaaagga gtttgtgcgt ccatctctga gcagcttttc aactcaaccg atggcacgta 50101 caaatgcgga gccatctggt gctgttcttc catcatgaca cccagcagat ctttgacggt 50161 tgtcgtttca gtccgtttga cccgcagcgg atacgtcttg atgaagaggc cgacgatttc 50221 ctctactcca gtgagatggg caggacgtcc ggcgtacgcc acttcaaaaa gcgcatcccg 50281 cgtatcactg tatttttgca gcaaaatacc ccatgcggct tgcaacagtg tgctgattgt 50341 cacgcggtaa cgcttggatg tttcctccaa tgtctccgta agcgttcgac tgagccgaag 50401 atgataagaa gaaaaccgcc gctcttcgtt acgatcccgc atatatggaa gcggcgtagg 50461 agagctaatt ccttgtaagg aatctttcca atacgataac gattgttctt tcgatgcttc 50521 tttgagaaaa cgcaaatact ccttgtattt cgccttctgt ttgatcgcag gggacagccc 50581 cgagcacaat tgtccatatg ctgtaaatat ctctcttagg agaatgccgg agctccatcc 50641 gtccatgaga atgtgatgaa atgaccatat gacttcataa cgatacaact ccatccttac 50701 tacttgaatg cgaatggtat tgccaaactc aagcgtgaaa ggtgtttgct tgtcctggga 50761 caacaaggca gacagttttc tttcacgcgc tccagatggt aactcgctcc aatcgaaata 50821 aggaatctcc aatgtctttt gcttgagaat gagctggaca ggggcttgaa gcccctccca 50881 gcgaaaaacc gtacgaagca tttcattggc ctcaattgcc atcgaaacag cctgcgtaaa 50941 caactccagc tgaaacttgc cacgaagagt tagccgatgc tgttcgaaat aaagattgga 51001 atccttttgg agtcggtagt aaaacagcat gccctcctgc gttggactta acggcaaaat 51061 gtcagctata ttgtttttgt cgatcttgtt catcacaatt ttctctcctg actcccttac 51121 cgaacagctt cactcggcag gttttccacg atctccccat ctgcattcac gtacggcaag 51181 ccattgtgtt cgaatacatg gtcgaggcag tacatctctc cctgtttgta gtccaaaatc 51241 atcaggtctt ctgaacgggt tgggattaat tccttcaacc gctctggaag atagtctggt 51301 ccgactgctt gatgccattt caaaacaatt ttctcagggc gctcggctgt cggataaaag 51361 ccacaaatct ctaattttcc aaagtcgtgg gaagtaagaa gtaccccttt tttctccaag 51421 ccacccagat tgcgcttgga ctcggccaca ttccggaacg cctcgtccaa tggaatggca 51481 tactgctcga cgcccctgac tggcataaac accgtcaaat aatacgaaat gatccgatta 51541 tccagaaact tgcgctgcaa gtcgatcaag gtctcaacag aatcgttaac gccacgaatg 51601 atggcaggct gtccgcgaat ctgtacaccg acggatagca gcgcttgcgt tgcttggatc 51661 gaaacgccac ttatttcccc aggatggttg aactgggaaa tcacacttac ctgcttgccg 51721 ggcgtctgtc ttacttggtc aaaaaacgcg agcagctctc catcaagaaa acgagcagga 51781 tcataggcca aagccttggt tgcaaagcga acgagtcgaa tactcttcac actcaataga 51841 gtgctaatta gcttgattaa gtcagaggtt ttacggaagg aagcagggtc tccaccggta 51901 aagaggacat tatcgatgta cggatgtgct tccaaatact gcactgccct ttctgcttta 51961 tccataatat tggtgtatcc aatatcctcg tggcggattt cgttcacttt atagcagaac 52021 tggcagttgg caatacaaaa gtcgtcgatg tgaagcaaca gtgtcttttt atacttgtgt 52081 tgcaggaaag cagtttcatc ctgacggtac gacttgtttc catacggatc aaagcggcct 52141 ttatagggtt tctttcccgg tggcggaagc acgatattga tcatctgcgt acgataaggc 52201 tccgattgac tcgcaatcaa ctcggcataa tagcgagtca ccttgaatgg catataagac 52261 tgctccagta atgcactgcg ttcttccctc tcagcttctg taaagccgac aattgctgcg 52321 aactcctcaa atcctttttt tcccattaac accttgacac tcaatgtaat ccctcctgtc 52381 atttattaaa cactcgtcat ctttgctttc tcggaaaact cgatcaagca tgagactcgc 52441 ttgttaccca aacagcaaat ccagctcttt ttgcgtcaat tccacatctt caaaatccga 52501 tggagtaaat tcagggacct cctgacggca gcaatgatca atgagttgct ccaattcatt 52561 gaaaaacaac gcaagtaact tctccatggt ctcctcgcga tacttgcgca agctaaacgt 52621 aacagaaacc tgaagttctc cttgacgaat gagagcagcc acgtcaagca gtgctgtcaa 52681 atgattaccc accccggcat caaccgccaa gtttcctccc attagtacca gatcatcact 52741 cagttggtta tcaacggatc ccagataatt gaatcgaaca tgtgactttt cctctgccgc 52801 gagtagctga ggctttagcc agccaaaccc aagccccccc atcggaatct gacgtaattt 52861 ctcctttact gcttttaggt gatcagtccg attggatgga ttcgtttcga acagaacagg 52921 atacatgcta gtaaaccatc ctactgttct agttacattc atcgtatgaa tagaagactc 52981 acgcccatgc gactccatta ccagcaagag acgctcccta tcaaacacat cagacaaagt 53041 ccgggtaagt gctgcaacca ataggtcttg gggacccgtg ttgaacattc ggttggccgt 53101 tgtcaacagt cgcgacgtca tctcggcaga aagtgtgcgt gtagatgtag cgctgtattc 53161 taccaagtct tcgccaaaat cgtagtcagt cggtagttta tcttccggga tggaaaacat 53221 gtcccaatat gctttttcat tgcttgcctg attcgactgg taaaaggcgg tgacttcctt 53281 gatccacgct tgcatcgaat gtgttttatc cggcaagaca atcggctcat tacgttttag 53341 actggccaag gcgctcatca aatcttccaa aagaatcctc caggagacac cgtccacaac 53401 aagatgatgg gccgtcagaa ataatcgctg aggtcgatcg ggtcctaatt caaagagaca 53461 accggtaaac agcaaagatt cttccaactt gaagctaaca gcgcaagctc tcattgcctc 53521 aagcattcta ctctcctgtt cttcttgcgg tacggaagaa aggtcgacgt aagatacaga 53581 cactcgattg gtcaggtgtc gctcattgta aaagagcttc ccctcttttg ccgagtaatt 53641 gagtcgcaga caatcgtgat ggttaaccag tgcagacaga ctcgcttcaa actcctccag 53701 cgttactttt tccttgcttt caaggagcaa cgactggttc caatgatcag cattgcggaa 53761 ctgttgtgac aaaaaccaag aaacgatggg agatgacggc aactcaccag tacacggctc 53821 ttgtgagatc tgttccactc cccagctcca gtcacttctc gcttttaatt ccgcaatcgt 53881 gtcataaatc aagatgtctc ttaccggaat cttgattcct cgctgatgca atcgatagga 53941 aacctgaatc gccttgatcg aatccccccc tagttgggaa aacgggtcat gtagaccaaa 54001 tggtgaacga ccaagcacat cctcatacac ttcaaccaat agcttgtcaa actcgtcacg 54061 aggactggtt tcatcctccg cacctcttcg ctcaatgacg ggttcgggaa gctgttttcg 54121 atctaccttg ccatttgagg tcagcggaaa ctgttcaagc tgcacgattt gcgaagggat 54181 catgtatgcg ggcaatcgac ctgccagttc ttcgcggagc tctttttccc ggaaagatgt 54241 ttccgtgatc aaataagcac aaaggtactt acgcccccat gtatccaagc gatcaatcac 54301 gactgcctca cgcacagaag aatgaccaag gagctgctgt tcaatttcac ccaattcaat 54361 gcggtaacca tgaatcttca cctgataatc agcccgcccc agatactcca tgactccatt 54421 gggccgatag cgaaccagat cgcccgtctt gtacatcact ttacctcgct gaaacggatt 54481 gggtaggaaa cgctcttgtg tcaattcctc gcggttaaga tacccccgtg ccacactatc 54541 tcccgaaatg aatagctctc ctgtcgatcc gatcgggatt ggtttcccat atgaatccaa 54601 aatgtagagc tgcacgttac tgatcggatg tccaatcgga acagaacctt cgacatcggt 54661 cgctggatcg tattgataga tcatgcaccc gactactgtc tcggtagggc catactcatt 54721 gagaatttcg atttgtccgt tccatttcgc atgaatcgcc tcagccagac tcaccttcaa 54781 gtcctcgccg cctacaatca ctcttttcac agtggtagaa ggcagcgcga tttcttgcag 54841 caaaaacaga tgggcaggtg tcagctttac aacatgggag cgtccgtcgc taaagatgcg 54901 cgataagaca aactctgaat cggagtgcgg atagataacc attcgatttc cctttaccaa 54961 cgggcaaaaa atggacgtaa ccgtcaaatc aaatgccagt gaggaataga aagcaaacgc 55021 ttcttcgggg caggagagat agcggtcttt cgcccacgaa atatagttga ctagccctcg 55081 atgagtaacc atgactccct tcggatttcc agtagagcct gatgtataaa tgacataggc 55141 caaatcatct ggctgattga ccgattccag gaattcgcca tcatttcgat acagggacga 55201 atcaccaagc tccaggattt cttttgacca cgagatatcc tttgttcgcg aagtgtgacg 55261 aagcaacagg tccgcttcag aatcagacag cagatattca atgcgctgag aagggagttg 55321 aggatcaatc ggaaggtaag tcccgccagc ttttagcact gccaacagcc cgatgatcat 55381 ctctggcgaa tgatctgcca gcaacgccac aattacgcca gggccaactc ctcggtttcg 55441 caacgattga gcgagtcgat tcacttgatc atgcagttcc tgaaatgtca gcgtgcgccc 55501 ctctgactcc aatgccactc cctgcggcga gcgtattact tgctcttcaa acaactggac 55561 aaccgtcttc tcgctgggat agggagccgc tgtatcgttc cacgcattga gttgtagtgc 55621 caactcttcg tcagcaagga agttcagatt ggagagcgga acttctggat tcgagattat 55681 ctgattgagc agccttacga gatgatccgc tattcgatca acatcatttt ccgtgtactc 55741 ggcgatctta tagtccaatt ccagcgtcaa tcgttcatct gttgcccatt ccctgataat 55801 tacttggagc gaatacaact ggtgaccgtt gtaaaactcc tcattggtca cggggtaccc 55861 accaagggtg aaaggcagct gcgtgctgta ataattcaca caaatctgaa acaggctgtc 55921 atagccatgt ttcttcagct ccaactcttg cgccagcaaa tcgtacggat atttctgatg 55981 aaaaaaacag gaagtaagtt ccctgttgac atatttaaca taatcgaaag catccatttc 56041 catcggaact gccagacgaa atggcatagt gctggtgaac atcccgaata ttttgcgctc 56101 cactttccct gaacggttta aaagcggtgt accgatcaca atttcttctt gcctcgtaca 56161 acgctgaagg taaagactga cgagcgccac aaacaaggaa tttaacgagc atttcatctg 56221 gtctgcatac tggcgtatcc ttgtcgaatc ttcagggtta aatgcataga ctttgcgctt 56281 gccttcggta gtatctgttg ccttttgtaa tgtcgtgatc acaggcaggc tctgaaactt 56341 gtcccgccag tatcgcttgt ccttttcaaa tctctcagac agagaatagg catgctccct 56401 ttcgacaaaa gcttgataag ggtgttcatc tccaacatga acggtaccgc ctgccagcaa 56461 cgtgtcataa tagtgagcaa tttgctctgt catgattgag atggaccaac catcagcaat 56521 caaatggtgc agctttacaa aataccccgc ttcttcgtca ctcagttgaa tcagacaaaa 56581 gtagaacaga ggctctcgtc cgatcgaaaa cggctttgta aataaagctt gcaggaattg 56641 tctgcaccga tcaggggcat tcggttcctg tctgaaatca aacacctgca atggctgtgg 56701 ttcgtactct ccagcaaatt gaagaactgt ctcttcctcc tgatagttga gtcgcaaagc 56761 atcgttcttt tgaatgaaca ggtgaatggc cgcttctaat acatccagtt tcacctttcc 56821 ttgaacccgc accatccccc ctaacgtatg gataggaagc tgtggatgta atttttccgt 56881 ataccagata cgcttttgtg gatgacttaa aggatatccc accttcgatt gcttcttatc 56941 ctggagcaat gcatatcccc ccctttcgga attgtgcaga tgtaatcaca attcatacat 57001 ggaaaaaaat ttaattgatt acaaatattt ccattttcaa ctataaagat ctatcttcta 57061 tagtgtcaaa taaatttttc ataaaatgta atttctgaaa attgaatgaa ttctatctct 57121 ctttcccttt tccagagctg catagaagag aaaaaagtta gtgcactcta ttgattttgg 57181 ctgtcttttc acgtaggata aatgtaatat attggtaaaa acaagccccc ggaaggatga 57241 atgtgattag atgtctgtga cacttcgtga agtaactttg gaaaactggg aagagtgtat 57301 tgaactggaa cctactcccg aacagagcga gtttgttgcc ccgaacctct actccatcgc 57361 tgaatcaaag tttcaaacta catttgttcc tttggccata taccatgatg acacaatggt 57421 tggctttgtc atgtatgggc ttgaccctga cgatggcaac tactggattt acagactctt 57481 aattgatgcg aagtaccaac gactaggcta cggacgtgct gcgattgcgc aagtcattga 57541 tatcctgaaa gcaaaggtag attgtcaaaa aattgtcatt ggttatgccc ctgccaatgt 57601 cgcagccgaa aacctttacg cttcactcgg atttcaaaaa aatggtatgg ttctgtttgg 57661 cgagacgatt gcggaattaa acttttaagc gagttttcgt tacccaaaaa tgaaacagcg 57721 gcgatctagg acctgaaaat caagtcttag cctcgccgct gtttgaattg tttcccatat 57781 attaaaaaag cacaccatcc atgtgtctgt aaacatcatg gttagtgtgc attcgttttt 57841 gatatggtgc cggtgaaggg acttgaaccc ccacggtttc cctcacgatt ttgagtcgcg 57901 cgcgtctgcc attccgccac accggcaagt gaaactatga ataaattaac acatcatcga 57961 tagaaaatca atggtgggga gagacggatt cgaaccgccg aacccggagg gagcagattt 58021 acagtctgcc gtgtttagcc acttcactat ctccccacaa tatgtgccgt ctatcttctg 58081 tgtctactct cttcaaccag aagcgacatt tattaatcta tcatgaactt tgtttgacgt 58141 caatatattt atttagattg actctctttt ttcgctaaga tttcctgtgc ccactcgtga 58201 aagacgcgca gggcttcatc tacttcttga aatgttgctt cttcctcaca ggagtattcc 58261 gggaagtcta gtatacggtt tttgcgaatc ttcacttgcc cttcttcgca ttttatctcc 58321 aagaagtagg gaacggcttc atctatccca taactgtttt ctaaaaactc gtaggtacgt 58381 acccactcca aaattcgaac ttccgatgct tttaagcgaa gcacctgctc caaggacata 58441 atcgtttcat tcccgtagta atacatgtta ttcagccctt ctgcatgaaa atggacggag 58501 ccgtgactcc gcccttttat tgatgtgata gattagatcg aggatagcag ctctctcagt 58561 tctttgacaa tcacttgctg gtaaccagtg ccttccccat actgctcgag catttcggca 58621 cgtgccactt tgatcttttc ttcataatct ggtgcgtttc ggtcagggtt ttgttgtttg 58681 aatgccgtca tgacagcttg gacatgcttt ggtctcggtc cccatttagc gagaacatgt 58741 ccaccggtgt ctgcgaaaat aacaacaggg atcgcccgac ctcccatagt aagaaactca 58801 tccatgagat cgaggtgttg ttccatcacc ataatttcca ctggcatgtc tgtttctttc 58861 agggcgtgca agacgactgg caagttgcga atgacgtcgc cacaccagtc cgcagccaaa 58921 atcaagcatc taagatcatc gcgatgctgg agagaggcaa aaaacgcacg gtcttgttca 58981 tcctcccatg agaatgcatc cgaccagttt tggtatgtat cctgattttt agtcatgctt 59041 tccacaaaca cctgtggctt gagccccgta cggaatttat gtgctacgtt tgcccccatc 59101 ttttctcctc cttttgtatc gctcgcctat tcttggtttt tatccgctgc ctcatttgct 59161 tccttttctt gattagccag ctccatcatt ttttgcaaca agatgtgctg cggcatgtgc 59221 atgagacgct ccaagggtac ctgaagcgct tccgccagct tgacagccgt ctccggtgat 59281 atttgtaatg gacgcatgtc atttttgctc ctttccctta ctttcatcag tcccttcagt 59341 ataatacaca gccgttaaac ctgccagcat acaagcctga cactggggag tctttggcct 59401 ttgtaacatg ttggctctac tgatacattc ttaatgaaaa tttaaaaaag agccacccgt 59461 aggcagctcc aaaatagagt caggctgttt gaccccttct caccgcacgc gaagggacta 59521 tctctcgtga acagaatatt ccgcacatgg aaaggacggg ctatggcttc tgtcttgtga 59581 gaatgcacgg tacaccaaag ccgatcgcac cgggccgaga catctgttcc agatatgcca 59641 atcctcgcgc gcattgctgc ttgcaaattt gacatgtttg ggacgatacg attttcagct 59701 gcatttgatt cgggtgctgc cgcgtgtcct tcttctttat ctttttaccc ttggccatcc 59761 gtttgcctcc ctttgccctg gatcactcca gtctatgaag gagaacagcc ctgctcttta 59821 ggcaagcata caaaatcaag atattcacct gcaaaatggg ccttgtcata cgtgtcaata 59881 catagaaaaa gccgccggag aattctaccc cagcgactta aatgtcttca ttatggtttt 59941 ggacttaaca actggcgcag ttccagctca agtgtaggag catctaccat gccaattatc 60001 ttctttcgta cgatcccatc cgcgtcaatc aagtaagtag ttgggaatgc caacaccttg 60061 taacggttcg acacagttcc agctacgtcc atcggtatcg gaaatgtcag cttgtagtta 60121 gtgacgaagg ccatggctgc ttccgggctg tcattgcttg tgacgttcac accatacaga 60181 tcaacctgtc cgccgtattt ttcatagact ttttgtaaat caggcgcctc catcttgcat 60241 ggtccacacc aggaagccca aaaattcaag accaatggtt tcgccctttt tccttctacc 60301 ttgtacgtct gctggtccaa tccggtcagt gtaaaatgag gagccgcaaa gccaacttca 60361 ggtttttgaa cctctgctac gattgcggct gtttcttgag gcttttccca aacagaaagt 60421 ccgaccccca ataatacgat aaccgcgagc aacagctttt tcattttgtc acctctgccc 60481 tactgagtta gaatcccgta aagcctccgt acatttgaat gagaacgcgt gtaatatccg 60541 tcaatttatc tgtatacaga agaatcccga acaaaatcat aatggctcct ccgattttca 60601 taaacaggtc ggaatatttc acaatcgctt tcaccttact gatgaagaac gtcatgacaa 60661 aaaacggaat ggcgaaaccg agtgtatacg ccaatgtgta agccaaggcg cttgaaggat 60721 tggatacgcc catgacgata atgccagaaa gaatgggtcc cacacacggt gtccatccag 60781 ctgcatacgt cattcccacc agtatggacc cagtataccc caatggtctc gattttaaat 60841 cgattttaaa cgaacgcatc atccaatcca ttttaaacac gccaagcata accaaaccaa 60901 taacagcaag caaaataccg cccagttgac gaatcaagtc ctgctggtcg gtgaacaaac 60961 ttccgatcca agatgtagac agccccagcg caacgaaaat gatcgaaaac ccgacaatga 61021 agaaaaaggt atgcaagaag gcttgcttgc gaaaaaccgc tctccctttt tttacttcat 61081 caatcgtaac cccagttatg taagacaaaa aggacggata aagcggcagg cagcaaggag 61141 aaataaacga gagaaaacct gctgcaaagg ccaaaaacac agttatatcg ccagtcatat 61201 ttacctccgg tgggtatttt atccactatc ctttcattgt atcgaatctt ttcccccttc 61261 aaaagtagca atgacacttt gtctaaaaac cgtgacaatt tccctttaca taataatgat 61321 tgatggataa aaccggttcg cttaaaaaaa tagatcagat ttttgacaaa tatgacatgt 61381 acctttcttg gaagatgtgt agatgatgag cagcatgacc aagaataaaa tagacgagtg 61441 cagctgcagt tgtcttgtcc tgaatgatca ctcccgaccg attcagttcg tcttccgtaa 61501 gtcctgttac cagtgatcgg gtagcagaac gcactgtctg aaactcctcg attaaatcgg 61561 caagcggtcg gcggtcaaaa ttcgtaaggc taacgaaaat gtcctgatgt cgtggcaagg 61621 gtgtcttgtc tcctcttgaa gcacacagca agcgatagct catgattctc tctgtatcca 61681 taatatggcc gagaacttcc tttacactcc attttccctc ctgataacgg tacatgctct 61741 gttcttcccc acatgaccga aacaaagcaa gtatttcttc ctcctgagca cgaagcagtt 61801 cattcagatc accttcagga gcaattttga tataggtttc aaattgcgca ggataatcat 61861 ctgactgtgg tttgcggaag tacattcgaa gtggcctcct tttttgaatg aggtgagcaa 61921 gcacttccat tgtacacaaa aaagaggcgg atgtactccg ccccttcctt gctattcttt 61981 ttcttactga atcgtgactt tgccgccatc ttgtagcagt gtttgccctt ttaccacgat 62041 cttatcgccg gcagacaagc ctgtcaaaat ttcgatctga tcactggagg atttgcctgt 62101 agtgacctcg acttgttttg caatgtcacc ttccagctta aatacatact gcttaccatc 62161 gcgatcaaaa actgcaccgc gcgttacaac gatcgatttt gctccacttt ccccagctga 62221 tgggaaggtt acattcacaa ccatatcgga cttcagctca ttggatgggt ttggaatcgt 62281 aatctcaact gggtatgcct tcagctgcgt atccatgact ggactcatcg ccgttacttt 62341 ggcatcaatc gtttttccac tcgattgtac gtttactttt acggtagttc ctacttttac 62401 ttttgtgata tctgcttctg acagatttgc ttttaccaga agtgggtttg tgttaacaac 62461 aaccacaacc ggttgctgac ctgccatttg accaacggcg ccgtttacgc tggaaatata 62521 tccgttgatc ggagaagtca cagtcgcatt cgccaattgc tcacgagcat tttgcagact 62581 cacttgtgct tgctgcacag atgcttcgga cacttgcaca cttgtttttt gcccagcaga 62641 ttgcaatgcc tgcatcgcgt tatcataaga agtctgtgcc gttgtcagtt gagaatttgc 62701 ctgttccatc tgctgagcgg aaatcgctcc ttgtgaaaag agctgttgca tccgctgctg 62761 atttactttt gcatcctgaa gggcagtttc tgcttgcttc aggctatttt ttgcttgcac 62821 caagccttga tcagagctac tgcctgcttg gtttaagctg gcttttgata cgttgtaagc 62881 tgcttctgct tgcttgacac cgttcaccag atctttttca tcgagcttga acaatacttg 62941 accttttgtc acgtattgac ccagtttcac tggcagggaa gaaattttcc cacctacttt 63001 cggggagact tgcacttcct cactcggtgc gagctttgcc gtgagaccag aatctgatac 63061 tactgtgccc gtagcaaccg ttccaacctg tacaggggtt gccgcttcca ccgtttccgt 63121 aggcggtgtt tccgcttgcg ggctggagca ccctgccact agcgtgatgg ccagcaatgc 63181 caaaatgacg ggttttttac ttagtttcat gtatgtccct cctcttccca caaacgtctt 63241 acgattccaa agcgggattg attttctttt gtttcttttc aagtttcttt tctagtttta 63301 acttgcgctt caagcgtctc tttttcccta aatcatcaaa ccaagaagca acgacaggaa 63361 ccagaaccag agtaatcaaa gttgagaatc cgagaccgaa aataaccgtc acggccattg 63421 gtgcgttcgt ctcggaaccg gcaccgccag agaatgcgag tggtccaatc gccagaatgg 63481 tggtgagtgt cgtcatcaaa atcgggcgaa gacgaatcgg cccagcgtgc aggatcgcat 63541 caaacagttc catacctttt gcacgcagtt ggttcacgta gtcgatcaat acaatcgcgt 63601 tgttcacgac cagaccgatc aacaaaatgt acccgatcaa aaccccaacg ctgatcgttg 63661 ttcctgtcgc caatagtcca agcagaacgc ctgtaacggt cggtggcacg gagaacatga 63721 tgataaatgg ggtgtagaac gattcaaact gcgctgccat taccatataa agcaacacga 63781 ctgacagtac aatcgcaaga gcaaggctac tgaatgattc catcatttct tcactttgcc 63841 cgccaaaatc gactttgtag ccatccggga gattcagctt cgaaattttc tcttgcactt 63901 cccgtgtgac agagctcagg tcacgccctg ccaaatcact cgttacttga acttcacggc 63961 ttgagttggc acggttaatc gatactggca cgtctacctt actgatagtc gcaaccgagg 64021 tcagcgcgat ctgtgcccca ccaggagcgg agattcgcat attgttcaag aagttgatat 64081 cttcctgata cgttttcggc agcttgaggt tgacgtcaat ctcatcatcg cccgtgcgat 64141 agtatgtaac cgtttgacct tggaaggaag tgcgaacact ggagagaatt tgtcctgtcg 64201 tcaatccgta cagactcgct ttctctgcat tgatcttcac ttccagctct tgccttgatt 64261 cttccaagct ggttgttacg ttactcgtac ctggtacctt ctcaatttca cctttaatga 64321 taccactgat gtctttcagt acggccaaat catccccgct cacctttagt tgaattgggg 64381 aaccagtaga cataccggct ggtgcgctta ccttaatttc tggtccagcg atatgcttca 64441 gcttttcctg gagatccatc acaatttcat tggaggaacg agttcgctcc ttgaggtcta 64501 ccagcatcag gctgatcgtc ccctgattgg aagacaaggt gctagcgatt ggtgatgcat 64561 tgctaccaac cgaagtcgaa acaatatctt tctccggtac ggtgttgaca atttcttcta 64621 cttgtctggt tactttttct gtttcagcca gaactgtacc atttggcatt ttgatggaga 64681 tatttacttg accttggtcc atggccggga taaactctgc cccgatcatc ggagttaatg 64741 cgagagagcc caccatcagg acaaccgaag aaatcataac tgttttacga tggcccaatg 64801 accattttaa caatctttgg tagccttttt ctactttgct aaatccaatg ttgaaccaag 64861 taactggatt aattccacga tagttctcat gatgtgtatg cgacggaatt ttgtttaaaa 64921 ttcttgaact cagcatcggc acgagcaaaa tagagaatac aagcgccgca atatgtgagt 64981 aaactaccgt cagtgcaagt ggtccaaaca actcagaagc aataccttct gtgagggcaa 65041 tcggcaagaa cacgcaaatt tgcgccaaag ccgaagccat tactgccgta cctacttctt 65101 tggaaccatc caatgcggct tccatcatac cttttccctg ttctcgatga cggaaaacat 65161 tctcgagcat aacaaccgca aagtcaatca atgatcccaa tcccaacgtc aaaccggaga 65221 gggaaatcag gttgatcgtc tgtccagaca tgtacatcag caagaacgta gcaacgatcg 65281 atacaggaag aacgatgacc gcaattacca tggatcgcaa gctgcccaag aagaagaaca 65341 gcaagatcat accgataccg ccacccaaca gagcatgttc agcggtcgtg taaacggaat 65401 ccttaatgta ggtggatgtg tccagagtcg taataatttg aacgccttct ggcagctcgc 65461 ttttgatttt ctccagctca gcttttacat catctgctac ctcaatggtg tttccgccag 65521 aagcttttgt cactttaaca cccaagctag gttttccatt tacgtaactc aattgcgtta 65581 catcttgatg cgtgtctttt acttcggcaa tatcgctgag cctgatggag tttcctccaa 65641 cagagattgg tgtcagcgcg atttgttcta catcggcaaa ctcaccttgt acacggatgt 65701 tgagcttggc gtcaccctcg cgtaccgctc caccggaacc tgacaagttg ctgctctgta 65761 gagcttgctg aacttggtca agtgacaatc catatgccgc tagtttggct gggtcgactg 65821 taacatcgat aatccggctt tgtccgccgc tgatggaagc agatgcgacc ccatcaatac 65881 gctccaggcg tgattggatc atatcctctg ccatcttttt caatttgttg atatcttgct 65941 cacccgtcac cgcaaactca atgatcggtg tactgttcgg gtcaatgcgc agtacgcgtg 66001 gcgctctagc tgagtcaggc aaagagccac gaacctgatc taccttctcc cgcatgtcga 66061 gagtcgcctg atcaaggtct gtcccccagt taaacatgag gataacctgc gaagcgcctt 66121 ccatcgatac cgattgtata ctatctaaat cggataccgt tgcaagtgcg tcctcaattg 66181 gcttcgttac cagtttttct acctcacttg gagatccgcc gtcaacggat gtaaccacga 66241 cagcaaccgg gaagttcaga tccggcatga gatcaatcgc caagcgaggc agtgagacga 66301 aaccaaaaat cagcatggcc agagtcaaca ttatcatggt gaccgggcgt ttaatcgata 66361 gttcagaaag attcaatcca ctcacctctt ctttatatat ctgctaattt tttgtgagaa 66421 atagttcgca taacgaaatg aataaggtga atttcgcagt gacatttcgt ttaacgaaat 66481 ataaaggggt gaaagcattc ttaaacggtt tgtgaatttc cccatttcac atctcgctgt 66541 tggtacacac gctctgtcag tgacacccac acaactcgtc gatctgcttg gtctcggaac 66601 ctgcgtacca ggttttcctg ctccaaccgg ttaatgagac cggaagttgt gctgtatgaa 66661 agaccgacag tcttacttat gtcccccatc gtttttggcc cgtttccaag ctgctccaga 66721 atcaagacct gttgccaggt tacatcgctt gtatccagct cttgctcaga aattgtggta 66781 aacaaaacac tggcttcttg caggagtttt gccaactgaa acagttcttt catgagaacc 66841 tcccttgcca tccttactta accactccac acccataact tgtcgtttat ttcccaaaaa 66901 taattctact gaaatatata tgtagtgaag tctacccagg ggtagatttc tgacaagtat 66961 ttatctatct ggagatagac gacaacgcat gctagaatga agttaagtga ttatccggca 67021 gagaaagaag gacttctcat tgttgaagat aatgatgaaa gccatacaaa aacgtttgct 67081 gatcatgtgg ttttccatct taattgtatt agctttgctt cctgattcat ttaaacggga 67141 aactccgttg caattttctc ttaccattgt actatttatt tgttaccttg tggtattttg 67201 gacttccaag aaaaaatgga agcctttcca attcgaatta gcgacagttg tgcttggaat 67261 cgtttcctta ctaaagtccc tcatcttggg tggagaggga ttcggcttga tgctcccact 67321 cgctgttttt atcggttttc acattcatgg acgccgtgcg ttggcctatg ctactttttt 67381 tggtacgtgt agtacgcttt ttttatattt tgaagaaaac ctgaaattca cgcacatcat 67441 ctcttatatt cttacgtatg tgggttgcta tatcggcgca cgtggctatc ggattcaaac 67501 agaagcatac gaaaccaacc aacagcacct ggagcagctg caaaaagcac atacagagtt 67561 gcaagaggca cacttacaac tccaagaagc agctctccat tcccttcaag tagcggttct 67621 ggaggaacga acgagaattg cccgtgatat tcacgatgca ttgggtcata gtttgacttc 67681 actcattgtc cagctacacg cactgaagta tatgttgcag gatggacctg acaacgcaca 67741 agaagccgtg cgcaacatgc tcggtgttgc caagcaaagt ctggaggata ttcgcacgtc 67801 tgtccataca ctggctctgg ataaaacctc cttggggctt acacctctgc gagctctttt 67861 gtctcaggct caaaaacata cgggaataaa gatggagctg atatgctccg atctggacat 67921 cccgctctct caggaaatga cgataacgtt ttatcgtatt ttgcaagaag cgatcaccaa 67981 ttccctacgt cattctgatg caaaagaaat tctcgtcatc atcgaacaaa agaaggacat 68041 ccttttcttg tccatccgag acgatggaag catcacgaga gaccaaaaaa tcaaacctgg 68101 ctttggcctg actggcatat ctgaacggat tcaattattg aacggaactc tcgcatatcg 68161 cattcgagag cctcacggat tccaactcga tttcagcttt ccgattcgcc agactgaacc 68221 tgaaaggagc atgcgaacat gaccggtaga caaaaagaag gagccattcg cgtggtccta 68281 gtagatgacc aaaccatgat tcgccaaggt ttaggttatg tcattcaaat gcaatccgat 68341 atggaagtaa ttggggaagc ttccgatggc gtagaagcag tcgaactgat aggcgccctc 68401 gtacccgatg tcgttttgat ggatgttcag atgcccaaca agtcgggtat tgaggctaca 68461 agagaaatca tgcagcagca tcctcgcaca aaggtattga ttcttaccac ctttgacaat 68521 cacaattatg tagtggacgg cattcgtgct ggagctgtcg gttatatgct aaaggatgcc 68581 gactctcagg aaatgcttga tctgattcgc agagcccatc agggagaagc cctcttccac 68641 accgtgacag ctgcaaaagc ccttgccgaa gctctgcaag gtcaacgtga gacacctgat 68701 tcgactacca cctcccaatc cgtcttgcta gatgaactca cggatcgaga gctggatgta 68761 cttcaacaga tcgcagatgg ctatcgaaat gatcagattg cgcaaaactt gtttatatct 68821 gaaggcactg taaaaacaca cgtgcatcga atcttgcaaa aaatgggtgt cgaggatcgt 68881 acacaggcag tggcaaaagc tctgcggcac aaaatcgtga aataaatcag acagttttag 68941 gcaggaggat taagtggaat caagtttcca tcctcctgct ttatgctgat ggaaacccct 69001 tcgcccagct ctgcaaaacc tcattaggcc ttccctcgat ctgctccgct actacagcaa 69061 aatagtcgcc aatttctcct acatttccgt aatgaacggt ataaaggtgc tctgattcct 69121 cataccaaac ctcccagtag ctccacctcg tttcgttttt ttcagcatcc gaatcactgt 69181 tgttcaactc cgttcaaatt gtaaccgttt tgtaaattat tccactaatc gacagacctt 69241 gacaacaact tacaaaaaga ttgattcgaa agacttgcaa tttttccgaa aacaggacta 69301 tttgcccatt tgaatataaa aaaagacgga tattcgatcc gtctacagtc acaatccttt 69361 ttgtttttta ggaaatggag agaggtaaac gtatctcaaa acgggctcct ttcagtttcg 69421 gtgagttttc cgcatagagt tcgccaccgt gatccgcgat gatgcgttgt gtcgtagaca 69481 aacctaaccc cgttccctct tgtttggtcg tataaaaagg aacgaacaaa ttttgcaagc 69541 aagaatctga tagaccaggt ccgttgtctt ccacaacaat gattacttga ttgagagagg 69601 agtacacttt cacatgaacg agattgcctt gggtcatcaa tgcttcaagc gcatttttca 69661 agatgttcaa gatcgcttgc ttgattcgtg aacgatgacc aaaaacatgc cactcgcctt 69721 gtgcaatatc cagctcaagc ttgattcctc ttcgatttgc ttctggctcc agtaaacgaa 69781 tgacgccata taactcgtcc atcactaaga aacgttccga tacgatttta tcatccctgt 69841 accgggccaa aacaagtaca tcgttcaata gcccatcaat acgttcaatt tccgttaaga 69901 taacagaaaa ataagattca ctacgatttg cttccccttg ctcccgtaac aactgaatga 69961 agcccttgat ggctgtcagt ggattgcgaa tctcatgtgc catcccagca gccagttgcc 70021 caactgctgc cagcgcttca cgcttgctca attcttcttc gtactttttg ctttccgtaa 70081 cattccgaag aacggcaatc gctccccaca tctctgtgcc gtaataaatg gggctcgtac 70141 tcactgtcgt ccatttgcct ctgtattccg caacataatg gccagactgc ccgcgttcaa 70201 tcacccactg gacaaaacgc tcgcttacat gaggacgaag ggcatgatca atgttttgac 70261 caatgagttg attccgatct acgccaaata aatgacagac agcgtaattc gcttcaatga 70321 ctctgaactg gcggtcgatc atcaagacgg caatgtcact ggactgcaga accaattgga 70381 caagctcctg ttcagcgagc attgtaacat cttctccttt agccgaactt gtaggagaag 70441 ctggtgtttt ctcaaccgga acttgatgcg aatttttgtt gaagacatcg tccatttgat 70501 acaaaatata gtccatcgat tgatagagac gaatctgtgc ttgcaaaagc tctactcgct 70561 ccatatccgt cgaggcaaga gaaaatgtgt tgttattcat ttcttcaata ataacgtctc 70621 gacacttgcg caaaaattgc tgcaaatacg taagattcat tccgagcaac gaaaatttgt 70681 aagcaatttc actcaattca cgctcgaatg catacgtgtc gactactttt actacttcaa 70741 tccatttcgt gatttgctga acaaacaaag cctctgtatt ttcgcggtct tctagaagca 70801 aagcagagta atgatgatct gaaagaaagg aaaacgtctt ggccaccgcc gcagagacca 70861 aatgagtaag atacttactt attcgatttt tcaaaacact ctggctcctt ttctccgtgc 70921 ttcattgagg ctatttttcc aagtatgtat aggctctatt atggacgtaa atgagacaag 70981 atgtaaagcg gcttgatgat atcctggcgc agggaataac accatccaat caggttctct 71041 tcttatcctt acagacaaac tatctcggct agcatcctat tttcgcgcgc tttttatttc 71101 ctttttcgga cactctcacc tcctgaacat gtttgactga aaccgcttac ccaacatttt 71161 ctatcatatc acgatcgagc ataaaaaggt caaggaagtt tattattcaa ccatccaaaa 71221 agcatttgcc cccgcagaga caaatgcttt cgctttatga atgggatttg acagcgtaat 71281 tgcgcaaatc cgattttacc gggctatttg ggttggttcc tgtatgcgcg cgcttgaaag 71341 cctcgctttc tgtccagttt ttaaatgatt cctcatctgt ccacttcgta aaaacaatgt 71401 attcgtcacc ttccgatggt gccaggaaaa ggaactccaa aaaaccagga acctccttca 71461 tccgttctcc tccattacca aatgcacgtt ccaaatggga ttggtagtct gctggtacag 71521 tcagtctgtt catggataca tacatgctgg tcacacgtcc ttttcattgg gttcatctac 71581 caactcccat tatactacta cttttggcga aaaacctaaa aaccgcaaac gctattcgcg 71641 cctgcggtta atttgttgct cgagcatgat atccatcaaa agtgtatcct gcaacggatc 71701 tttcgggtct accgtcaaca gggcagcaac agcggccatc gcacatcgaa cggattggta 71761 ggaataaaag gcatctcgct ccgattcgct gaacaatgat atatccgatc gctcttgggg 71821 agggtatggg aagtcagtct cgacaccagc acgatccaga acaatgagtg cctgtttaat 71881 cgcaatcaat gccgcgctga cactaatgcc gtattcttgg cgtagatctt cccacacctg 71941 aaaagctgat ttttctaccc tttcctgatt ggggcgcgta atgattcctg ttttgcgccc 72001 ttctttcaat aaccaatcca caaaaatatc gttgcgtgga ggaaaagcat atacttgcag 72061 cttcatttcc aattctgtcg ggttatcctt ggcaaaacgc gcgtgagcca acgacatttc 72121 gtaacgccga gatggatgcc caggaacggt gacaaatact gtatcttgtc gcacagctgc 72181 gatttgcagc ttggttcgcg ctggtatcct gccttgaggt gccttttccc tgcgaatatt 72241 accgggaatc aattctactc cgaattgatg gtactccagc ggtgaatcta tccagggaat 72301 gggctctctc gtctgtattt cgtatagtcc gttaaacgtc acccattcgc ccgggcggcg 72361 ttggctgcga accaaaacag catgaatttc cttttctggt ggcaattccg tatcttgatc 72421 ctcctgtggg ggatgcattc gcttgtgttc gataagaatg cagtcggtca tgaacaatcg 72481 ctcgagcaat tcccgcttgc tcacccattc atatccgatg cggtaaatcc gatttttcat 72541 cggcttcacc tccttttgat cgccattatt gcatcatcct ggtttgtttc tattacccta 72601 ccatatgtaa tcgtcgcttt gtccgtgcta acgagatcgt acaatctgct gaagcgcttg 72661 cgctgcttct tctggtgatt cggcctggct gatcgcactg ataatcgcga ctccatcggc 72721 cccggcagca agtacttcag cagcgttttc cagtgtaatg ccaccaatcc cgacgatagg 72781 caagtcatta ccaactgcct tacggatctc cgctagcccc actggtccga taggctctcc 72841 agcatctgcc ttggaacgtg tagcgaacat cgctcctaca ccgatacaat cgacgccacc 72901 gttttgggca gcgagtgcct cgtcgaccgt acctgccgaa acaccgatgt acatctcgga 72961 gccaactttg gctcgtactt ctgccaacgc catgtcatct tgcccgacat ggacgccatc 73021 tgcctgcaag cgaatcgcca gatccacatc gtcattcaca aaaaataagg tatcatggtc 73081 acgacatagc tgttgcagct gtctgcccag ctcatattgt tcctgagcag ttagcttgct 73141 tcctttatct cgtagctgaa gcgtgcccac tcctccgcgc aatgctgctt ctacaatttg 73201 cacggtcttt tcgctggaat acccgcaatc ctgcgtacca acgacaaagt agacacccat 73261 cttttcccga agtctttgta tatttcgcac gctttatttt ccctcccaac gatccaatgc 73321 ctctcgataa gcgctggctg cggacttggc atccgttgca tcggtgatcc ccgataagac 73381 agcaatgccc gcacatcctg cttccaaaac ttgcgcagtc cgatccggtg taactccgcc 73441 gagtccgatg atcggcacat gccatcttgc tgtcatccga gcgagttcga ttgttcctct 73501 tggcgcaaga ccaggcttcg aaccactcgc aaaaatatgc ccgtagagca aataatcgac 73561 ttttgcggca atggcttgct gtgcttcctc cgtggaatgg atggaacgcc ctattttttg 73621 accagtcttc agcaccattc tcgcttccac aggagacaga ctatggtatg ccaggtgagc 73681 accggcacaa cccgacgcag cagccacatc cacccgatca ttcacgatca aggacgaaag 73741 ggggatgacg tttgccaatg cctttaccca gtccatgcat tcctttgcgg tacgctgttt 73801 ttcccgtatg tgtaaaaagt tcataccacc tgcataagca gcttctgcca ttcgcaatac 73861 gtcatcaagc gaatgccgac cgctcgtaat cacatgcagc tcacgagtgc ttgacatcag 73921 gttgaacacc gcctccagcg agtgctgtca cacattcctg cagccagtgc gtcgttcggt 73981 cttctttgtc cgtcggggac tgagccaaca gctcaatcac aagccgacgc aagaaaaaag 74041 cttgttgcac ggtaagtgga aaagtaatat tttttggctt ggtttcctgt ttctccaacg 74101 tctctacgcc cgccaacaaa atatcaccga tggactccac gagttcgcga acctgctcat 74161 tttgcttcaa ttcgtcatag cagccatcat atagtctgca caaaagtaaa aacgcctgtg 74221 acgacaaggt caccggctgt acattctgca tcggttccgt catacgtttc cctccactcg 74281 ctagaaaaac aaaatctatt atatcacatc atgacctgta taaataaaac aacatctatc 74341 gctgccttct catggaggag cgaccgcatt ttagtggaaa gttgttatcg gctccagaat 74401 tcataagctt atgaattcct ccacgatgaa gaaaaccgct gattgctcag cggtcttttg 74461 cagttccttc atttcgatca ttatggttcg attgtcgcaa atttgtgttg cgatcatttt 74521 catccagcgt tttaccacga tttttcccga ggtctttgct gttgttgttc tttcccaatt 74581 gattcacctc ctacgtcgtt cataggatag cgtaaccaat ttgggtcact ttattagctg 74641 attgcgtgta gtctattgcg tttgtagatc gcgtagccga tggcgaacgg tacacgccac 74701 ccgagcaaaa acgccagcgt aacgaaataa gtcacacctg caaaaataag cgtagtcggt 74761 acaccagtcc accaggagcg gatcagcaag ccaatcggtg ctgctagtgt ccaagtaatc 74821 agtgccgata ataattgtcg acccgcagat tcatacgttc gctgtccgta gctcttgaat 74881 agcagaattg cgatgatcca tcccacgagg aaaggggcta atgtttcgat aatccccatg 74941 accgtaacag agtagttatg aatgattttt ccgtaataaa caaaaagcac aaaggcgatc 75001 agatccccga gcaacaataa atagcccggt gtcgacaaac gcagtctcat gtataccctc 75061 ttttccgggt cttatcagag taaaccctct tggttcaccc ctattgtaca catgctctga 75121 acgcccttca atcaatccaa gcctttattc accaaacagc aacaattgca gcttttgctt 75181 ggcttctggc cattcacggt cgagtatgct gaagtatacc gagtcgcgaa tgtatccatc 75241 tggcatcacc atatgattgc gcaggactcc ttctcgaatg ccaccgattc gggcaatggc 75301 acgctgcgaa ttcaaattgc gcgaatctgt cttgagctgt acgcgaatac accctaattg 75361 ttcgaagcag tggcgcagga gaagccattt acattccgta ttgacgcccg ttttccagac 75421 ggatggggtc agccatgtaa acccgatttc caaaccgcga tcctttttcg ctatccctaa 75481 aaatctcgtg ctcccgatga tctgctcatc tgtttggcga ataatcacga atggcaattc 75541 tgtttgggct tgttcatttt ttaaagcctg caggataaaa gcctgagcat cttctcttgt 75601 tcgaatggta acggacatat gcggccaaat ctcttcgtag gcacctgctt tccagatacc 75661 gtccacatgg gccattctaa gcggctccaa tcggacaagt ttgcctttta agataacagg 75721 ttcaatgttt aacatgtctg cctctcctct actgttctgc ttcatccatc aagcagaaca 75781 gcttcccgaa atttttccaa tgatacgggc tcgcgaggac actgtcaaga caaataatta 75841 agacgttacg cttcttcact aataatgact tgcttccctc tgcgctttaa gaagataggg 75901 attagcaacc acagaagtgc acaaaccaga aaagcagcgg aaagcggctt tgtcaaaaag 75961 atggaaaagt caccattcga ggtggtcaat gctcttctca tgttattttc aatcatcggt 76021 cccaacacaa gaccgaggac gagcggtgca agcggaaaat cgtttttcgt caggtaatag 76081 ccagctaccc cacaaatcac aagcaaaatc aagtcaaacg tactgatttg cacagcgtac 76141 acaccgaaaa cggaaatcgc gataatgagc ggaatcagga aatgggacgg tgtttcaata 76201 attttggcaa acacttttac caatggcatg ttcaaaatca acagcataac atttccgata 76261 aacatactcg caatcaagcc ccaggcaatc tgcgggtgat cactaaacaa tagtggcccc 76321 ggctgtacgt tatacatcaa taatgcaccc atcaaaatcg cagtggtacc ggagccggga 76381 atgcccaacg tcaacagtgg aatcatcgct cctccagaag cagcattgtt tgcagactcc 76441 ggagcggcta cacctgcgat cgctcctttc ccaaaacggc taggatcttt gctcagcttt 76501 ttctcaaaaa tatacgaaaa gaaggatgcg agggtagcgc cagcacccgg caaaacacca 76561 atgaaaaatc cgagcaacga gccgcgtgta atcggtccgg cactttcctt taagtcttgc 76621 ttggtaggga gtactcgccc cactttaata atttccttgt tcgattgatc gtcttccagg 76681 attgtcttga acacttcccc taaagcgaac aaaccaaccg ctatcgtgag gaactccaga 76741 ccttgataca aatcaggaat atcgtaggtg aatcgcgcca cgcccgaaac ggtatccatc 76801 ccgattgtcg caagcaagag tcccgtgact gtcataatga gggctttggt catggatttt 76861 ccgccaagtc cgcttacggc acacaagcc //