LOCUS NZ_CP018145 22622 bp DNA circular CON 05-MAR-2024 DEFINITION Brevibacillus formosus strain NF2 chromosome, complete genome. ACCESSION NZ_CP018145 VERSION NZ_CP018145.1 KEYWORDS RefSeq. SOURCE Brevibacillus formosus ORGANISM Brevibacillus formosus Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus. REFERENCE 1 (bases 1 to 6437015) AUTHORS Fu,B. and Li,Z. TITLE Direct Submission JOURNAL Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: HGAP v. 3 Genome Coverage :: 167.68 Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 03/05/2024 02:46:36 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.6 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,168 CDSs (total) :: 5,986 Genes (coding) :: 5,821 CDSs (with protein) :: 5,821 Genes (RNA) :: 182 rRNAs :: 16, 17, 17 (5S, 16S, 23S) complete rRNAs :: 16, 17, 17 (5S, 16S, 23S) tRNAs :: 127 ncRNAs :: 5 Pseudo Genes (total) :: 165 CDSs (without protein) :: 165 Pseudo Genes (ambiguous residues) :: 0 of 165 Pseudo Genes (frameshifted) :: 85 of 165 Pseudo Genes (incomplete) :: 95 of 165 Pseudo Genes (internal stop) :: 22 of 165 Pseudo Genes (multiple problems) :: 35 of 165 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 14:35:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 2392507 Orig. end :: 2415129 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to CP018145.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ This genome has a base modification file available. COMPLETENESS: full length. FEATURES Location/Qualifiers region 1..22622 /candidate_cluster_numbers="1" /contig_edge="False" /product="lanthipeptide-class-iii" /region_number="9" /rules="(micKC and not PKS_KS)" /tool="antismash" cand_cluster 1..22622 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(micKC and not PKS_KS)" /kind="single" /product="lanthipeptide-class-iii" /protoclusters="1" /tool="antismash" protocluster 1..22622 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[10000:12622](-)" /cutoff="20000" /detection_rule="(micKC and not PKS_KS)" /neighbourhood="10000" /product="lanthipeptide-class-iii" /protocluster_number="1" /tool="antismash" proto_core complement(10001..12622) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(micKC and not PKS_KS)" /neighbourhood="10000" /product="lanthipeptide-class-iii" /protocluster_number="1" gene complement(289..1320) /locus_tag="BP422_RS10910" /old_locus_tag="BP422_10605" CDS complement(289..1320) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729333.1" /locus_tag="BP422_RS10910" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10605" /product="ABC transporter substrate-binding protein" /protein_id="WP_088907746.1" /transl_table=11 /translation="MKPFNKWTKAFMALTLATGLAACGNQASTDAGQTQAPADKATEPT ELTIALDWYPNAVHSFLYVAEEQGYFKDENLKVTMQMPSDSNDPLKMAAAGKVDLAISY QPQLIQARAEGVPVVSVGALVRHPLNVIMTRQDSGIDTPQKLAGKNIGYPSLPLDESIV RQVVKHNGGDDSGLTFTDIGFDIVPALTAKKVDAVVGGYINHEQLILEKHGIPVNVFKP FEFGVPDYYELVLATSDETLGKKQKAVEGFLRAIGKGQDYVKNNKEKALDLLLAKQAAD FPLEKDIETKSLDTLIPLMDAGEKPFGYQTVESWQTLIDWMKKEKLITTDVKAEEIMRD LVK" gene complement(1317..2075) /locus_tag="BP422_RS10915" /old_locus_tag="BP422_10610" CDS complement(1317..2075) /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1044: ABC transporter, permease protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248963.1" /locus_tag="BP422_RS10915" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10610" /product="ABC transporter permease" /protein_id="WP_088907747.1" /transl_table=11 /translation="MGRGIWFGISIAIFLLVWEAGCRLLGVPPFILPPPSAVVVSLWDL RASLVGVHLWATLKEVLLGLSISIVFGISLAFAMIRSRIVERLVYPYIVISQTIPIIAL SPVFILWFGYDLSGKIAVTILFTFFPIVVNAYDGLRSTDKEMLQLLKTMGATNGQIFTK LQLPSSLPHFFSGLKVAATYSVAGATIGEWLGASEGLGYFGRRASGNFQAPALFASVLL LSILGMLLFWLAGRIERHFSPHMKIKGEQQ" gene complement(2075..2857) /locus_tag="BP422_RS10920" /old_locus_tag="BP422_10615" CDS complement(2075..2857) /EC_number="7.6.2.14" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729340.1" /locus_tag="BP422_RS10920" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10615" /product="ABC transporter ATP-binding protein" /protein_id="WP_088907748.1" /transl_table=11 /translation="MGEQLAFADVSFSYGDRQILDHFDLRVEKGEFVSLIGPSGIGKST LFQLIAGLLEPGQGEIRLGSVPVANRLGKVGYMPQRDLLMPWRTIVENAALPLEIKGMT KKEAHERVRQQLPRYGLQDWADRYPAQLSGGMRQRVSFLRALFSGAEIMLLDEPFSALD GITRMDMQEWLMEKWQETGSTMLMITHDIDEAILLADRIIVLSGSPITKPIELTVPVSR PRTASSRNQAGFLALREQIWELLRQERQAAMKPLRREA" gene complement(2842..3522) /gene="tenA" /locus_tag="BP422_RS10925" /old_locus_tag="BP422_10620" CDS complement(2842..3522) /EC_number="3.5.99.2" /GO_function="GO:0050334 - thiaminase activity [Evidence IEA]" /GO_process="GO:0006772 - thiamine metabolic process [Evidence IEA]" /codon_start=1 /gene="tenA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729343.1" /locus_tag="BP422_RS10925" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10620" /product="thiaminase II" /protein_id="WP_088907749.1" /transl_table=11 /translation="MATFTDRLRKSVAPIWERVHQHPFVTGLGDGSLPVGAFKYYMKQD YIYLIDYAKMFAIASVKAYDLETSSRFAALQESTLNTEMELHRQYAERFGISRAELEAT EPSFVMLGYTSYMLRVAHQGSLAELVSALLPCTWSYWEIGKRLAQVEGALDHELYGEWV RMYSSDEFGQLAIWLIDIMNQLAEGKSEQELAKLEEYFVNTSKMEYMFWDMSYREEMWP WENN" gene complement(3530..4825) /locus_tag="BP422_RS10930" /old_locus_tag="BP422_10625" CDS complement(3530..4825) /EC_number="3.5.1.16" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1247: acetylornithine deacetylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248966.1" /locus_tag="BP422_RS10930" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10625" /product="acetylornithine deacetylase" /protein_id="WP_088907750.1" /transl_table=11 /translation="MSSVDRLTEAVESIASRKEELFALLAELVSHPTVSPPARNSDAAQ GVIANRLQAMGFEVDRWTVYPGDDNIVGRLSGRASTHANSLIINGHIDVAEVGDDTGWT YPPFALTHGKDGRLYGRGVADMKGGLAASLFAIQILREHGVELQGDLLFQSVIGEEAGE AGTLVAIERGYQADYAVVVDTSNLQMQGQGGVITGWITIESPTTLHDGMRAQTIHAGGR VRGASAIEKMTKVITALQELERDWAVMKSYPGFPPGSNTINPAVIEGGRHAAFIADRCA LWITVHFYPNESYEEIIREIEDHVGRAAAADLWLRDNPPTFRWGGRSMIEERGEIFLSL ELDTEHPGLAMLQSAYESHMHQTPIVNMSPTVTDAGWFAHAGIPAVLFGPGELTHAHAV DESIDPDQLVHFAQIMARFIATWCNTPKEAKE" gene complement(4818..5591) /locus_tag="BP422_RS10935" /old_locus_tag="BP422_10630" CDS complement(4818..5591) /EC_number="2.8.1.10" /GO_function="GO:1990107 - thiazole synthase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729347.1" /locus_tag="BP422_RS10935" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10630" /product="thiazole synthase" /protein_id="WP_167385117.1" /transl_table=11 /translation="MMDTLKIGPYEFRSRLLLGTGKFADLDTQGKAVEVSEAEILTFAI RRLNLENPQEPNFLEQLDLKKFTLLPNTAGAYTVEEAVRIARLAKASGLCDMIKVEVIG DPKTLLPDPIGTLEASKILVEEGFIVLTYTNDDPILARRLQEVGVHAVMPGASPIGSGQ GIVNENNLRFIIEDAKVPIIVDAGIGSPADCAKAMELGADGVLLNTAVALADNPVLMAE AMKLGVEAGRKGFLAGRIAKKRYASASSPTEGMIE" gene complement(5597..5800) /gene="thiS" /locus_tag="BP422_RS10940" /old_locus_tag="BP422_10635" CDS complement(5597..5800) /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /GO_process="GO:0009228 - thiamine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="thiS" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016743632.1" /locus_tag="BP422_RS10940" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10635" /product="sulfur carrier protein ThiS" /protein_id="WP_016743632.1" /transl_table=11 /translation="MIVQLNGKKVELAEEITTVRALLASYSLQEKIVVVERNGDIIDRS AYEQTPIADGDRIEIVHFVGGG" regulatory complement(6000..6110) /bound_moiety="thiamine pyrophosphate" /db_xref="RFAM:RF00059" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00059" /inference="COORDINATES: profile:INFERNAL:1.1.5" /note="TPP riboswitch; Derived by automated computational analysis using gene prediction method: cmsearch." /regulatory_class="riboswitch" misc_feature complement(6056..6073) /note="TFBS match to ArcA, Repressor of carbon oxidation, confidence: medium, score: 19.23" /tool="antismash" gene complement(6152..6535) /locus_tag="BP422_RS10945" /old_locus_tag="BP422_10640" CDS complement(6152..6535) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729350.1" /locus_tag="BP422_RS10945" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10640" /product="kinase-associated lipoprotein B" /protein_id="WP_088907751.1" /transl_table=11 /translation="MNWNPGDIVRVTQRTGEYIAEVLEIHDSKLLVKVLAVTKYPTQGD LHSSYEVDVPLFHQRPALSYMEKFMTPAQGVIRYNGAIPDYKESVRQAMEREMEKLAKM AAWAERCLVELEKMHKEAFTNTK" gene complement(6569..7780) /locus_tag="BP422_RS10950" /old_locus_tag="BP422_10645" CDS complement(6569..7780) /GO_function="GO:0003676 - nucleic acid binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729351.1" /locus_tag="BP422_RS10950" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10645" /product="DHHA1 domain-containing protein" /protein_id="WP_088907752.1" /transl_table=11 /translation="MDDRLYYQDAYTRTFSAQVTRTGVEQDGTPYVVLNQTAFYPTGGG QPSDLGVLEEIRVVDVEEVDGEIRHRLEAPLSESIGEVTGHIDWDRRFDHMQQHAGTHI LSASFLEVVQAETVAFHLGKERVTIDVRLDELTADVWEKVEKRANQIVMENHPIIARFV DDEELATLPLKKQPTVTENIRVVMIPDFDYNPCGGTHPARTGEVGMIKILGWEGHRGNI RLEFICGWRALRDYNQKQAVVRDTAKLLATNEGELIAQTERLLAERDTLKAKLAEVDKQ LLGVEVNQQLAAASQLGHSHLIMCTFTDKTIQQLQQFAQLATALAPDAICLLAATTEDK VQVVFARGQEVNVAINQVLKETLPVINGKGGGNPAMAQGGGQSVVDAEDVLLHARKLLE ASLM" gene complement(7862..8089) /locus_tag="BP422_RS10955" /old_locus_tag="BP422_10650" CDS complement(7862..8089) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005828760.1" /locus_tag="BP422_RS10955" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10650" /product="hypothetical protein" /protein_id="WP_236841360.1" /transl_table=11 /translation="MGECKLDHSHEDVLKKLAEQAPHLSELRVSQFKHQLNGELSQERL NELFHLLKKYDLASPEERQEREKQMDHLFG" gene complement(8185..9468) /locus_tag="BP422_RS10960" /old_locus_tag="BP422_10655" CDS complement(8185..9468) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248973.1" /locus_tag="BP422_RS10960" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10655" /product="glycoside hydrolase family 18 protein" /protein_id="WP_088907754.1" /transl_table=11 /translation="MQIHVVEEGQTLASIAETYGTTPEAITEANELPDPNKLVTGQAMV IPIVGSYYWVKQRDTLYTIGQRYQISAAELARINRIPQYRPLQVGQRLYIPPRPRRAAD FNAYVEPRRTVTPAMEADVRTAAPHLTYLAPFSFRIRRDGTLVRPTLNNFPQIAKENQV LLMMVITNLEREQFSTELGELILNNQELQNTLLNNILQTARELGMGDIHFDLEALPTTG AEAYANFLRKARDRIHAAGLMMSVALAPKTSAEQAGKWYTAHDYKAIGAIADFVVIMTY EWGYSGGPPMAVSPIGPVRRVLQYAITEMPADKILMGQNLYGYDWTLPYERGTTARALS PQAAIALASQHNAVIRYDYRAQAPFFTYTDNQGKQHRVWFEDARSIQAKFNLVKQLGLR GVSYWKLGLPFPQNWLLIEENFRVRKRS" gene complement(9533..9841) /locus_tag="BP422_RS10965" /old_locus_tag="BP422_10660" CDS complement(9533..9841) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248974.1" /locus_tag="BP422_RS10965" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10660" /product="thioredoxin family protein" /protein_id="WP_088907755.1" /transl_table=11 /translation="MQELTSTELIQYLQERESVALFVYTPMCGTCKLAARMLGIMQETL PTVPLYQININTAPALAEQWQVTSVPALLIFHKNELIERHYAIQSVGFLYEVLKPLA" gene complement(10001..12622) /gene="lanKC" /locus_tag="BP422_RS10970" /old_locus_tag="BP422_10665" CDS complement(10001..12622) /GO_function="GO:0004672 - protein kinase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0005975 - carbohydrate metabolic process [Evidence IEA]" /GO_process="GO:0006468 - protein phosphorylation [Evidence IEA]" /codon_start=1 /gene="lanKC" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-iii: micKC" /gene_functions="biosynthetic-additional (rule-based-clusters) Pkinase" /gene_functions="biosynthetic-additional (rule-based-clusters) LANC_like" /gene_functions="regulatory (smcogs) SMCOG1030: serine/threonine protein kinase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248975.1" /locus_tag="BP422_RS10970" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10665" /product="class III lanthionine synthetase LanKC" /protein_id="WP_088907756.1" /sec_met_domain="micKC (E-value: 1.8e-136, bitscore: 454.8, seeds: 18, tool: rule-based-clusters)" /sec_met_domain="Pkinase (E-value: 6.2e-16, bitscore: 57.0, seeds: 54, tool: rule-based-clusters)" /sec_met_domain="LANC_like (E-value: 3.4e-11, bitscore: 41.0, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MKANMVYYDYLNENSKYFTPNKSIVTEREFNVTNLSDDCVVSREE NSVWKMYKFKERSLQAQGWKIHISATLDNAEQILQKVSHILVERKVHFKHLASEWDYFT TNSKTANRASSGKFITIYPPSDDDFLNLLDLLYTTLHSFESGPYILSDKCWKNSNVYYR YGGFAMIFNEQGELCMKDENGELLVDERVPYYKVPTFVKEFDQYLDSLNTTSIEADVEN NKFEEYEFQSALRFTNGGGIYVTERKKDKKKVIIKEARPKSGLDGQKVDALERQKIELD ALSKLSKVDGIVNILDYFTHWKHSFLVEEYVDGIDLDSWIVANYPFINNGDIKVYKNKI HNILTKLVSIVEEMHKNGVGMGDLQPANIIISEDLNVTLIDFETARPKDSEGKPTLQTY GFSHPRNKNNGERDWYAIKKILRHCLLPIGPIEDIDSDMYDYQDQWIEKVYGEDFLLFV KMIREKCNQHLSFIGEENRSHAINKNAMKKDVSSIIEGLRNGIEKNFVRSEKLIHGDIR QYESKAGKYNVQNGGTGAALAFFRSGTVSENINHWIENELMRNIDSIEQGGLLTGKAGI GTTLYEIGYKKEAMNIFANMNLNSSDISLRSGLSGIGLGFVSLYLEEKDERFLDKAIFV ASIIDTFMSEKKELKVQDWAGIPIGIMDGWSGVSLFYSALYAVTKKENYYLKSIECIDK DLEKTKEDKSTLQTIDDSNRLLPYLSGGSLGIGIAIVYLNHVSDKKRYQRELSLITNLY RVRCSLSGGLYDGAGSFLIIPPLLGKSDSEYTNKKDCVIELLRLFLIPKENHILFPGQF CYRLSDDFQTGSSGIILALEGILKDNPLYWLPLINIDDFYKNTKYSQDVACVNAAPTTI KQ" CDS complement(12764..12868) /gene="allorf_2405271_2405375" /locus_tag="allorf_2405271_2405375" /protein_id="allorf_2405271_2405375" /tool="antismash" /transl_table=1 /translation="MNQVLNLQKLPQNEASEVAARWSLYSNICPWPWG" CDS_motif complement(12809..12868) /prepeptide="leader" /note="peptide class: lanthipeptide" /note="predicted sequence: MNQVLNLQKLPQNEASEVAA" /locus_tag="allorf_2405271_2405375_lanthipeptide" /aSTool="lanthipeptides" /tool="antismash" CDS_motif complement(12764..12808) /prepeptide="core" /locus_tag="allorf_2405271_2405375_lanthipeptide" /peptide="lanthipeptide" /predicted_class="Class III" /score="1.20" /molecular_weight="1729.0" /monoisotopic_mass="1727.8" /core_sequence="RWSLYSNICPWPWG" /aSTool="lanthipeptides" /tool="antismash" /leader_sequence="MNQVLNLQKLPQNEASEVAA" /leader_location="[12808:12868](-)" /alternative_weights="1747.0" gene complement(13217..14107) /locus_tag="BP422_RS10975" /old_locus_tag="BP422_10670" CDS complement(13217..14107) /EC_number="1.1.-.-" /GO_function="GO:0050661 - NADP binding [Evidence IEA]" /GO_function="GO:0051287 - NAD binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1100: 3-hydroxyisobutyrate dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729360.1" /locus_tag="BP422_RS10975" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10670" /product="NAD(P)-dependent oxidoreductase" /protein_id="WP_088907757.1" /transl_table=11 /translation="MEAIGVIGIGAMGKGMVCNLLQKGYHVYAYDPSPAAKAWAKERGA IVVESPQAVGSVARVVFTSLPGPAIVEEVMLGADGLFLSLGAGSFVFDTSTIDPATAKR LNQHGVEKGIYYYDCPVSGGPAGSAAGTLTIMVGGDEAKLPEIMDYLRAIGKEIFYLGE SGSAQVAKLCHNSVVAVITAALGEAFTVGAKAGVDPHKLAAVMDKGSAHNRVLSVFGPN ILYGTYENTVFSLDHMHKDLQLYAQTAREQQVPVLVGGTVAQMYEAAKAQGKGSWDSSA VCTVTEELAHTTISR" gene complement(14134..15585) /locus_tag="BP422_RS10980" /old_locus_tag="BP422_10675" CDS complement(14134..15585) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aldedh" /gene_functions="biosynthetic-additional (smcogs) SMCOG1017: aldehyde dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729364.1" /locus_tag="BP422_RS10980" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10675" /product="aldehyde dehydrogenase family protein" /protein_id="WP_236841361.1" /sec_met_domain="Aldedh (E-value: 2.9e-159, bitscore: 528.9, seeds: 89, tool: rule-based-clusters)" /transl_table=11 /translation="MTVTYNNYIAGAWVASHTGQVFPSTNPANTNEVLGYFQKSDGLDA RSAIEAAANAFGEWSQKSAPTRGEFLFSLIHLLEKHKEELAETITREVGKTLREARGEV AKTITSMKQLTGEATRLTGQTVPSFDERVIGYTVREPIGVFAIIAPWNFPLGIGLWKIV PAILAGNTVVFKPASNTSLISVKLVELLIESGVPSGVVNLVTGPGAVIGEELTNHPLVK GISFTGSSEVGLALGRAVGARGGKIQAEMGGKNPAIILADADIDLAIDSIVLSGFFDNG QRCTGTSRVLVVPEVAEQVKAKLIERAKGLKIGNGFDPDNHNGPVVDEHQLNLYLHYVQ KGMEEGGVLECGGKRLVEDDLAQGYFVAPTVFTGITQEMTIANEEIFGPVIAVIDVDSF EHAMQVANQVEFGLSSTIFTNDLQKAFQFVKGIQSGVTHVNMPSTHFESQFPFGGKKIS GLGPREQGESAFDFYVETKTVYIRP" gene 15709..17844 /locus_tag="BP422_RS10985" /old_locus_tag="BP422_10680" CDS 15709..17844 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729366.1" /locus_tag="BP422_RS10985" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10680" /product="helix-turn-helix domain-containing protein" /protein_id="WP_088907758.1" /transl_table=11 /translation="MNSFSLLLEKLHKWFGDQPFSILFQFSRDRHFRLVFSSFHENAAT NIPPMTVPLCDNDASHMRYAFESLPSQQMYRFFYENEGQAVICLAHQAKLPIILTADQW ELLWFGFRLLLAEEKMTAKTEESKKLFEGIRSISATLDVHQIIRGIIGNALAVIPAADA GLLHLYDPTIDRLIPKATVGFHDTVFKDLKMRVGESIAGKVFEDGIPRMYKTSQETTHA MKDISADNFHSLNHAKALRDLNGLLCVPISREEKRIGVLVLHQFHQENVFTDYDLDLLQ GFADQTSIALQNAELYAEVKQAYEHMASISAQLQAKHDDLIQRNHIHESIKQLSLQNKG AETIVKTLSKMTGHSIYFADWLEQKMYPEKSAVFFSWDELYTLLNKKRQPVSVNLFTPA SGDDQLFCLYPLINGSIFLGCLMIPLDERGLSDLARMTVEQGSAVLILDLVKKQSISSV LYKRAHDLFQELIASKGNELFDRARSMGLQPQAEYYVIYAHLTQCHDLALLEANIHRLI TRWKWEFSKTQMLVYGFHNHVTLLIRSLGSRDGKDIRERLQQASDEWELGKEASLSIGV GSMASGIEQISKSYEEAKKAAHYLTNRGRSGVVYYKDLGVNRLMLNQSQADIDAFIQDV FAPFWQDPEKYQEWEQTIITYMKCSQSPQLTAKELHIHVNTLYQRLRKVEELLHIDLRN PEDLLKLQLACHLRQEG" gene 18147..18743 /locus_tag="BP422_RS32070" CDS 18147..18743 /EC_number="2.3.1.-" /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF024157.4" /locus_tag="BP422_RS32070" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="GNAT family N-acetyltransferase" /protein_id="WP_236841362.1" /transl_table=11 /translation="MFAQKMVQGTELTTDCFHSATNLFEALKHHVSIKGVIAGVIPGRV FLSNDARSALLTSPQGIFLGGSVDNPLFFKEVNTLLKEELLPQLAADEQLDYVLFYPTD EKWDDILDIVMKDVFPMRSGRMIFTHHLEDLSPLADDHIFPINSTLLKRKELVGLEDVI DEIAENWPSIEAYENKGFGCAAIQDTDEGPPNNAG" gene 18749..19177 /locus_tag="BP422_RS32075" CDS 18749..19177 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS32075" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_236841363.1" /transl_table=11 /translation="MGWQCWSNNIGSQRTALSVGFELLADFPVLFGWNLPLNNFLVNGN HYMRGDLKYGVEKDYARAAWSYAQALDEGWDWNGDAALYWNAACLFYLSGEEDRAKHYY KKAIEHGWVSIHHPHYHDDVYREQDSEQIARILAESLK" gene complement(19448..19888) /locus_tag="BP422_RS11000" /old_locus_tag="BP422_10695" CDS complement(19448..19888) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS11000" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="BP422_10695" /product="hypothetical protein" /protein_id="WP_236841364.1" /transl_table=11 /translation="MTKLFQLNSEDDIEKVVAQSQQIAQKALQEYDLDGEHADEKITED QVYKEGVLLAKLHTVSQDFQLPPEFARPIWGEDSFKQSMSRLREHYQQFLTDEEFVLYQ LAADKILTCLAKLDMNSSNYGVIHGNLHQAIPFWGYILNKER" misc_feature 20024..20042 /note="TFBS match to HgtR, Hydrogen-dependent regulator, confidence: weak, score: 24.01" /tool="antismash" gene 20024..20761 /locus_tag="BP422_RS11005" /old_locus_tag="BP422_10700" CDS 20024..20761 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1171: transcriptional regulator, MerR family" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729375.1" /locus_tag="BP422_RS11005" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10700" /product="MerR family transcriptional regulator" /protein_id="WP_088907760.1" /transl_table=11 /translation="MLYTVNDVAKLSGTTIKTLYHYQKIGLLMPEIVTENGYRYYGENE LKRLQQILFYRELDLSLDSIKAALDHEPDRLRCLCEQQTMLKARQLRLERILNTLEETI QHERKRGNMSTENMFDGLNEEEWKQAFTQQNEHLQKAYDFQFDTENLDVTSLNEKAAEA KAFMTFMADALKNNRSVDDKTVVSAIESHLAFLQKDHPIDAKAFAEQSRFFLSDEFHRT MLEEQQTGLSYYICIAAENYASK" gene complement(20844..21863) /locus_tag="BP422_RS11010" /old_locus_tag="BP422_10705" CDS complement(20844..21863) /EC_number="3.-.-.-" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1053: beta-lactamase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007729378.1" /locus_tag="BP422_RS11010" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_10705" /product="serine hydrolase" /protein_id="WP_088907761.1" /transl_table=11 /translation="MQRSYWPTTEWQAADPAILNIDAEKLAELDPIIKSAYSNINGIVV VRNGYLAHEKYYHGYGPKDRNHVASVTKSILSALIGIALEERFIKNVDQKVLEFFPDYA PDHTDEQKQAITIRHLLTMTAPYPFEDWHEPLDKMCMQSDWVKYTLDMLGQKGTIGAFK YSTAGAHLLSAILTRSTGKSAREFANERLFTPIGMEEIPDYEMKWFASDDLFGKDVRGW VKDPDNNSTGGWGLTLTPRDMARFGWLYLNRGCWDNHQIIPEAWIDESIAMNPNQYGYL WWLREEDGVFAYAAIGDGGNVICCIPEKNLVVAIASEFMPNPRDRWMLIKEHIIGAVI" ORIGIN 1 aaaggcattg agaaaggcat gctgcctgac ttggtggaat tgccttattc gtcaaaaaga 61 aaatctccct cacacaatgg tcatggtctc ggtttgccca tggttgcacg tattgctgcc 121 gctcatcatg gacacctgct gttaacaagc gatacaggaa aagggattac agcagaactt 181 tgtttccccc tctcctccta aaagaaagag cacctcctct gtatcgccaa tggagagtag 241 actctcaaaa gcgtgcaaag gggtgctttt tgactgattc tgggtcaatt acttcacgag 301 atcgcgcatg atctcttctg ccttgacgtc agttgttatc agcttctctt ttttcatcca 361 atcaatcagt gtttgccaag attccaccgt ctggtatcca aatggctttt ctcctgcatc 421 catcaacgga atcagggtat ccaaactctt ggtctcaatg tctttttcca gagggaaatc 481 cgcagcctgt ttggcaagca acagatcgag tgccttttcc ttattatttt tcacatagtc 541 ctggcccttg ccgatcgcac gcaggaaacc ttccacagct ttctgctttt tgcccaaagt 601 ctcgtcactt gtcgccaata cgagctcata atagtctgga acaccaaact caaaaggctt 661 gaacacattg actggaatgc cgtgcttctc caaaatcagt tgttcatggt tgatatagcc 721 acctaccact gcatcgacct ttttggccgt caatgctggg acgatgtcaa agccgatatc 781 cgtgaaggtc agtccggaat catcgccacc attatgcttc acgacttgac gtacgatcga 841 ttcgtcaaga ggaagtgatg gataaccgat attttttcca gccaactttt gcggagtatc 901 gataccactg tcttggcggg tcatgatcac gtttaacggg tgacgaacga gtgcacctac 961 agatacgaca ggaactcctt ctgcacgagc ttggatgagc tgtggttgat agctgattgc 1021 caaatccact ttgcccgcag ccgccatctt caacggatca ttgctgtctg aaggcatttg 1081 catggtcacc ttgaggttct cgtctttgaa atagccttgc tcctctgcga catacaagaa 1141 ggaatgtaca gcattcggat accaatcgag cgcaatcgtc agctcagtag gctccgttgc 1201 tttatcagca ggggcttgcg tctgaccagc atctgtgctc gcctgattgc cgcaagcagc 1261 aagacctgtt gccaaagtaa gtgccatgaa tgctttcgtc catttgttga aaggtttcat 1321 tgttgttctc ctttgatttt catatgcggg gaaaaatgac gttcgattcg tccagccagc 1381 caaaacagca gcatgccgag aatcgagagc aacaggaccg aggcaaacag cgcgggagcc 1441 tgaaaattgc cagatgcccg tctgccaaag tacccgagtc cctcgctcgc tcccagccat 1501 tccccaatgg ttgcccctgc cacactgtag gtagctgcca ctttgagacc actgaagaaa 1561 tggggtaaac tcgacgggag ttgcagcttg gtgaaaattt gtccgtttgt tgcccccatt 1621 gtttttaaca gctgaagcat ttctttgtca gtcgagcgaa gtccatcata cgcgttgacg 1681 acgatcggaa agaaagtaaa cagaatcgta acagcgattt ttccagataa atcatacccg 1741 aaccacaaaa tgaatacggg tgataacgcg ataatcggaa tcgtttggga gatgacgata 1801 tacggataga ccaagcgctc cacaatccga ctgcgaatca ttgcaaatgc aagggagatt 1861 ccaaatacaa tcgagatcga tagccccagt aacacttcct ttaacgtcgc ccaaagatgt 1921 acacctacta gagaggcacg taaatcccac aaagacacaa ccacagcgct aggtggtggt 1981 aaaatgaatg gcggcactcc gaggaggcgg catccagctt cccacaccag tagaaaaata 2041 gcgatggaga taccaaacca aatgcctctc cccatcatgc ttctctcctc aacggcttca 2101 ttgctgcttg gcgctcctgt cgaagcagtt cccaaatttg ttcacgcaat gccaagaatc 2161 cggcttggtt gcggctgctc gccgttcgcg gtctgctcac cggaacggtt aattcgatcg 2221 gcttggtgat cggactacct gaaagcacga taatccgatc tgcaagtaaa atggcttcgt 2281 cgatgtcatg tgtaatcatc agcatcgtac tgcctgtttc ctgccacttt tccatcagcc 2341 actcttgcat gtccattctt gttattccat ctaacgcact aaacggctca tccaacaaca 2401 ttatctctgc accagaaaac aatgcgcgta aaaaggaaac ccgctgacgc atcccaccgg 2461 aaagctgggc tggatatctg tcagcccaat cttgaagccc gtaccttggc aattgctgtc 2521 tgacacgctc atgcgcttct tttttcgtca tacctttgat ttccagcggc aaagctgcat 2581 tttcgacaat cgtacgccat ggcatgagca gatcgcgttg gggcatataa ccgaccttcc 2641 ccaaacgatt tgccactggt acactgccga gcctgatttc gccttgtccc ggctcaagaa 2701 gacctgcgat gagttgaaac aaggtgcttt tcccgatccc gctcggaccg attaagctga 2761 cgaattcccc tttttccaca cgcagatcaa aatgatcgag aatctgcctg tcgccatacg 2821 aaaagctgac gtcggcgaaa gctagttgtt ctcccacggc cacatttcct ctctgtagga 2881 catgtcccag aacatgtact ccattttgga ggtgttgaca aaatactctt ccagtttggc 2941 cagctcttgc tcgctcttac cttccgccaa ttggttcatg atatcaatca gccagatggc 3001 caactgccca aactcatcgg agctgtacat gcgcacccat tcaccataca gttcgtgatc 3061 caacgctcct tctacttgtg ccaagcgctt gccgatttcc caatagctcc atgtgcatgg 3121 gagtagtgca ctcaccaatt ctgccaacga cccttgatga gcaacacgca gcatgtagct 3181 ggtgtatccc aacatcacaa acgaaggctc ggttgcttcc agctccgcgc gagagatgcc 3241 aaaacgctcg gcatactgac gatgcagctc catctctgtg ttcagcgtcg attcttgcaa 3301 agcagcgaat ctggagcttg tttccagatc gtacgccttc acactcgcaa tcgcgaacat 3361 tttcgcgtaa tcaatcagat agatgtagtc ttgtttcatg taatatttga atgcaccaac 3421 gggcagactg ccatctccaa gtccggtgac gaaaggatgt tgatgaacac gctcccagat 3481 cggggctacg ctttttctca aacgatcagt aaaggttgcc atgctattct cactccttcg 3541 cttcctttgg ggtattgcac caggtggcga tgaaacgggc catgatctgg gcaaaatgaa 3601 caagctggtc aggatcaatt gattcatcta cggcatgagc atgcgttaac tcaccgggcc 3661 cgaataggac agccggaatg cctgcatgcg caaaccagcc tgcatccgtc accgtaggcg 3721 acatattaac gataggggtt tgatgcatgt gactctcata tgcggattgc agcattgcca 3781 accccggatg ctccgtatcc aattccagtg aaaggaagat ttcaccgcgc tcctcaatca 3841 tcgaacgccc accccagcgg aatgttggag gattgtctct caaccaaaga tcagctgctg 3901 ccgcacgccc gacgtgatcc tcgatctctc gaataatctc ttcgtaggat tcgttcggat 3961 aaaaatgaac agtaatccag agagcacaac ggtctgcgat gaacgcagcg tgacgacctc 4021 cctcgatgac tgcgggattg atcgtattgc tgcctggcgg gaagccggga taggacttca 4081 tgacagccca gtcccgctcc agctcctgta gtgcggtgat caccttcgtc attttttcaa 4141 tggcagaagc tccccggacg cgtccgcctg catgaatcgt ctgtgcacgc attccgtcat 4201 gcagcgtcgt cggactctca atcgtgatcc accctgtaat aaccccgccc tgcccttgca 4261 tttggagatt gctcgtgtcc actacaacgg cgtagtcagc ctgatagcca cgctcgatgg 4321 cgaccaatgt ccccgcttca cctgcttctt ctccgattac ggattgaaag agcagatcac 4381 cttggagctc cactccgtgt tcccgcagta tttggatcgc aaacaagctc gctgcgagcc 4441 cgcctttcat atccgcaact ccacggccgt acaggcgccc atccttgcca tgcgtcaaag 4501 caaaaggtgg ataggtccac ccggtatcat ctccgacttc agccacatcg atatgtccgt 4561 tgataatcaa gctgtttgcg tgggttgagg cacgccctga taaccgaccg acgatattgt 4621 cgtctcctgg atataccgtc cagcgatcca cttcgaatcc catcgcttgc agtctgttgg 4681 cgattacacc ttgtgcggca tcgctgtttc gcgcgggagg actcacagtc gggtgagaaa 4741 cgagctctgc caatagggcg aacagctctt ctttgcggct ggcaatcgat tctaccgctt 4801 ctgtcagtcg atccacgcta ctcaatcatc ccttcggtcg ggctgctcgc ggatgcgtaa 4861 cgctttttcg cgatacggcc tgccaggaag cctttgcgac ctgcttccac tccgagcttc 4921 attgcttctg ccatcaggac aggattgtca gcgagtgcga ccgctgtatt caacaagaca 4981 ccgtcagcac ccagctccat cgctttcgcg cagtctgctg gagaaccaat tcctgcatct 5041 acgataatcg gtactttggc atcctcgatg ataaagcgga ggttgttttc gttgacaatc 5101 ccttgtccgg aaccaattgg tgacgcacct ggcataactg catgtacgcc aacctcttgc 5161 agacgtctgg caagaatcgg gtcgtcattg gtgtaggtca gcacgataaa gccttcttcc 5221 accaaaattt tcgaagcctc gagtgtgcca atcgggtcag ggagcagtgt tttcgggtct 5281 ccaataacct cgaccttgat catgtcacac agtccagatg ctttagccaa acgggcgata 5341 cgcactgctt cttctactgt ataggcacct gctgtatttg gtaacagggt gaattttttc 5401 aaatcgagtt gttccaaaaa gttcggttct tgcggatttt ccaaattcaa gcgacgaatc 5461 gcaaaggtca aaatttctgc ttccgacacc tctaccgctt tcccttgtgt atccaaatca 5521 gcgaatttac ctgtccccag aagcaagcgg gagcgaaact cgtaaggtcc aattttcaat 5581 gtatccatca tgatgatcat cctcctccga caaaatgaac gatttctatg cgatctccgt 5641 ctgcaatcgg tgtttgttcg tacgcagagc gatcaataat gtcaccattt cgctctacga 5701 cgacaatctt ctcttgcagg gaataagaag caagcaaggc acgcactgta gtgatctctt 5761 ccgccaactc tacttttttc ccattcagct gaacaatcat tgattacctc cttctactgg 5821 aaaaaaaacg gcttctcccg cctgcctgag tcggttcaga caaacagaag aagccgtata 5881 cccatcccat ctcaccggac gaatggcata aaaaaaccat ccgccccgga tggttgagtg 5941 tcatcttatc atctatgcgc ataaacaagc atagttccgc tcggatgcga cacgtgatac 6001 tgattccaaa tacctcttcc tccgctggca tgacccaggt caggttcaac ggtcagtaac 6061 acactcgtta caatctcagc caacgttgct tggcccccgt ttggtagtaa tgctatgcaa 6121 ttgtcgtaca ttcgagtatt acagtaccac tctatttcgt gtttgtaaag gcttccttat 6181 gcatcttttc cagctcaacg agacaacgct ctgcccaagc tgccattttc gcaagctttt 6241 ccatttctct ctccatcgcc tgacgcacag attccttgta gtctggaatc gctccgttat 6301 agcgaatgac cccttgtgca ggtgtcatga atttttccat gtacgacagt gctggacgct 6361 ggtgaaacag cggtacatct acttcgtagg aagaatgcaa atcgccttgc gtcgggtatt 6421 tggtaactgc cagcactttt actagcagct tcgaatcgtg gatttccaat acttctgcaa 6481 tatattcacc agttcgctgc gtaacgcgaa cgatatctcc cggattccag ttcatcgcgg 6541 tttcctcctt ttattcaatc gaatgcattt acatcagtga ggcttccagc agtttgcgtg 6601 catgcagcaa tacatcttcc gcatccacta ctgactgacc gccaccctgc gccatcgcag 6661 gatttccccc accttttccg ttaatgaccg gcaaggtttc tttcaacact tgattgatgg 6721 ctacgttgac ttcttgtcca cgagcaaaca cgacttgcac tttgtcttca gttgtagcag 6781 ccaagaggca aatcgcatct ggcgccagag cagtagcgag ctgtgcgaac tgctgaagct 6841 gttgaatggt tttgtctgta aaggtacaca taatgaggtg agaatggccg agttggctag 6901 cagcagctag ttgttgattg acttccactc ccaagagctg cttatccact tctgccaatt 6961 ttgccttcaa ggtgtcgcgt tctgcaagga ggcgttccgt ctgcgcgatc agttcccctt 7021 cattggtagc gagcagcttc gccgtatcac gaacgacagc ttgcttttgg ttgtagtccc 7081 gcaaagctcg ccagccacag atgaattcaa gacgaatgtt tccacgatgt ccctcccagc 7141 ccaagatctt gatcatccca acttcgcccg tacgcgctgg atgtgttcct ccacacgggt 7201 tgtaatcaaa atcaggtatc atcacgacgc gaatattttc cgtaacggtc ggctgttttt 7261 tcaagggcag cgttgccaat tcctcgtcat caacgaaccg cgcaatgatg gggtggttct 7321 ccataacaat ctgattcgct cgcttttcta ccttctccca tacatctgct gtcaactcat 7381 ccagtcgtac atcaatagtg acacgttctt tgcccaagtg aaaggcgacg gtctccgctt 7441 gcacgacttc caggaaggac gcggataaaa tgtgtgtacc agcatgctgc tgcatgtgat 7501 caaaacgacg gtcccaatcg atatgacccg ttacttcccc tatgctttcg gacaagggtg 7561 cttccagtcg atggcgaatt tcaccatcta cctcttccac atctaccaca cgaatctctt 7621 ccaatacgcc cagatcggaa ggctgtccgc ctccagtagg gtaaaaagcc gtttgattca 7681 gtaccacata aggtgtccca tcttgctcga caccagtcct cgtcacctgg gccgagaatg 7741 ttcttgtata ggcatcctga taatagagtc tgtcgtccat cgttactcct cgctgcatgg 7801 aaccatggtt ccagcctgtg tctccctcta gggggcaaaa cgaaaaacat atgtataaag 7861 cttagccaaa caagtgatcc atttgttttt cgcgctcttg gcgctcctct gggcttgcca 7921 ggtcatactt tttcaataaa tgaaacagtt cgtttagacg ctcttggctg agttcgccat 7981 tcaactgatg tttgaattga ctcacacgca actccgacag atgtggagct tgttctgcca 8041 gttttttgag tacgtcctca tggctgtgat ccaatttgca ttctcccatg atttctcccc 8101 ttttccttcc tgtcatcttc atcataccat gattttccat tcgaaaaaag gcgtacaatc 8161 cgcgatggaa tgtacgccag ataactatga acgcttacgg acacgaaagt tctcctcgat 8221 caacagccaa ttttgcggaa atggcaaacc caatttccag tagctgacgc ctctcaagcc 8281 aagctgttta accagattga acttggcttg gatcgaccgc gcatcctcaa accacactcg 8341 atgttgctta ccttgattat cggtgtacgt aaaaaacgga gcctgcgcgc gatagtcata 8401 ccggatgacg gcattatgct gggaagccag tgcaatcgct gcctgtggac tcaatgcacg 8461 cgctgtcgtc cctcgctcgt acggtaaggt ccagtcgtat ccgtacagat tttggcccat 8521 caaaatttta tcggctggca tctcggtaat cgcatactgc aagacacgtc gtaccggacc 8581 aatcggggaa actgccatag gaggaccgcc actatagccc cattcatatg tcatgatcac 8641 gacaaaatcg gcaatggcac caatcgcctt gtaatcatgg gcggtatacc atttgcctgc 8701 ctgctcggca cttgtcttcg gtgccagcgc aacagacatc atcagtcctg ctgcatggat 8761 acggtctctc gcttttcgca agaagttggc atacgcttct gcaccggttg tgggtaatgc 8821 ttccaagtca aaatgaatat ctcccattcc cagctctcgt gctgtctgaa gaatattgtt 8881 caacaaggta ttctgaagct cttgattgtt gaggataagc tcgcccaatt cggtgctgaa 8941 ctgctctctt tccagattcg taatgaccat catgagcaga acctggtttt cttttgcgat 9001 ttgcggaaaa ttgttcaatg tcggtcgcac gagagtacca tcccgtctga tacgaaagct 9061 gaacggagcc aaatatgtca gatgcggtgc agccgtgcga acatcggctt ccatagctgg 9121 tgtgacggtg cgtctcggtt ccacataagc attgaaatcg gctgcacgcc gcggacgggg 9181 cgggatgtaa aggcgttgcc cgacttgaag cggtctgtat tgcggaatcc tattgattcg 9241 tgcaagctct gccgcactga tctgataacg ctgaccgatg gtatacaacg tatctctttg 9301 cttgacccaa tagtagcttc ccacaatcgg aatcaccatc gcctgtccag ttaccaactt 9361 attaggatca ggcagttcat ttgcctcagt tatcgcttcc ggggtcgttc cgtacgtctc 9421 ggcgatgctc gctaaggttt gtccttcttc caccacgtgg atttgcatac tccccctcct 9481 tcgcatttct tctctctttg tcatattcac ggcgaaggta ataggtgtat gtctaggcaa 9541 gaggtttcag aacttcgtat aaaaacccaa cggactggat ggcataatgg cgttctatca 9601 actcattttt gtgaaagatc agcaaggcgg gaacactggt cacttgccat tgttctgcca 9661 atgcaggcgc cgtattaatg ttgatctgat acagcggaac ggtaggcaat gtttcttgca 9721 tgatgccgag catacgtgct gccagcttgc acgtcccaca catcggtgta tagacaaaaa 9781 gagcgaccga ctccctttct tgcaggtatt ggatcaattc tgttgaggtt agttcttgca 9841 agtcgtatct ctcctttctg cacattggac acgatacagg atctaaacaa cctttttctc 9901 tttcgcaaac aaaaaacgac agcaaccaac cataaggtag cactgtccat tttgttactc 9961 ttatacaatt atggaacaaa gccaactact actctacgcc tcattgcttg attgtagttg 10021 gggcggcatt tacacatgct acatcttggc tatattttgt atttttataa aaatcatcga 10081 tatttattaa tggaagccaa tataatgggt tatctttcaa tatcccctct aaagctagta 10141 taataccaga actccctgtt tgaaagtcat cagacaaacg ataacaaaac tggcctggaa 10201 ataaaatatg attttcctta ggaattaaaa ataaacgtaa caattctatt acacaatctt 10261 ttttgtttgt gtactcagaa tcactttttc ctagtagagg cggtattatc aaaaagcttc 10321 cagcgccatc gtaaagcccc ccgcttaagc tacatctaac acgatataaa ttagtaatta 10381 agctcaattc tctttggtaa cgttttttat cactaacatg atttaggtat acgattgcta 10441 ttcctatacc taacgatccc cctgaaaggt aaggtaataa gcgattggag tcatcaatcg 10501 tttgcaatgt gcttttgtct tcttttgttt tttctaaatc tttatcaatg cattcgatag 10561 atttcaagta ataattttcc tttttggtga ctgcatacaa agccgagtaa aacaacgaga 10621 ctccagacca accatccatt ataccgattg gaatcccggc ccaatcctga acttttaact 10681 ctttcttctc gctcataaaa gtatcaatga tactcgcgac aaatattgct ttgtccagaa 10741 aacgttcatc tttttcttct aaataaagac taacgaaccc aagacctata cctgacaatc 10801 ctgaccttaa agatatatca gacgaattaa gattcatgtt tgcaaagatg ttcattgctt 10861 cttttttata accgatttca tataatgttg tccctatgcc tgctttacct gttaataatc 10921 caccttgttc aatagaatcg atgtttctca ttaattcatt ttcaatccaa tggtttatat 10981 tctcactcac agtaccagat ctaaaaaatg ctagcgcagc tccagtgcct ccattttgta 11041 cattgtattt cccagctttg ctttcatatt gcctgatatc accatgaatt aatttttcgc 11101 tacgaacaaa atttttctca ataccgtttc tgagaccttc tataatggag gaaacatcct 11161 ttttcatcgc atttttattt atggcatgcg acctattctc ttctcctata aatgataaat 11221 gctgattaca tttttccctt atcattttta caaatagcag aaaatcctct ccataaactt 11281 tttcaatcca ttgatcttga taatcataca tatcagaatc aatatcctcg attggtccaa 11341 ttggcaataa gcaatgtcgt aggattttct ttattgcata ccaatccctc tctccgttat 11401 ttttattacg tggatgagag aatccgtatg tttgcagtgt aggctttcct tcagaatcct 11461 taggtcgtgc tgtttcaaag tcaatcagag tcacgtttaa atcttcggat atgatgatat 11521 ttgctggttg taaatctccc attcctacac catttttatg catttcttca acaatagaca 11581 ccaatttagt aagaatatta tgtattttgt tcttatagac tttgatatca ccattattaa 11641 taaaagggta gttcgctaca atccaggaat ctaagtcaat tccatccaca tactcttcca 11701 caagaaaact atgtttccaa tgtgtaaagt aatccagtat atttacaatt ccatctactt 11761 tcgatagctt tgataaagca tcaagttcga ttttttgtct ttctaatgca tcaacttttt 11821 gaccatccaa tcctgatttt ggccttgctt ctttaataat gactttcttt ttatctttct 11881 tcctttctgt cacatagatt cctccaccat tcgtaaagcg aagtgcactt tgaaattcgt 11941 attcttcaaa tttattattt tctacatcag cctcaataga tgtggtattt aaagaatcta 12001 aatactgatc aaattcttta acaaaagtag gtactttata gtaaggaacc ctttcgtcta 12061 caagcaattc accattttca tctttcatgc acaattcgcc ttgttcgttg aatatcattg 12121 caaatccgcc atacctatag taaacattgc tgtttttcca acacttgtca ctcaggatgt 12181 atggaccact ctcaaaagaa tgaagagtgg tatatagtag atctaataaa tttaaaaaat 12241 catcgtcact aggaggatag atcgtaataa actttcccga acttgctcta tttgcggtct 12301 ttgagtttgt agtaaaataa tcccattcgc ttgcaagatg tttgaaatgg actttacgtt 12361 caaccaatat atgactgacc ttctgtaaaa tctgttctgc attatcaagt gttgcactaa 12421 tatggatttt ccaaccttga gcttgcaagg atcgttcttt aaacttgtac attttccata 12481 cagaattttc ttccctgctc actacacaat catctgataa atttgtcaca ttaaattctc 12541 tctcagtaac gattgatttg ttaggagtga aatatttcga gttttcattt aaataatcat 12601 aataaaccat gtttgccttc atgatatact ctcctctcat aaatgattta tgtacctctc 12661 ccaataattt gtaagctaca tcttatgtat tcgtctcatt caaaaggacc tagttgaagt 12721 tagccttcaa ctaggtcttc tctgaagaag cactttacaa ccattacccc catggccaag 12781 ggcaaatgtt actatacaat gaccacctag cagctacttc acttgcctcg ttttgaggaa 12841 gtttttgtaa attcagtact tgattcatta taattcacct ccttccaaaa tttagttcaa 12901 atgtcgtgac tattattttt caaatctata aagcttgtac tatattaatg ctccggtctt 12961 catcgcgaac taaaattcta accaccttta aatcgaattc atattacata ttttaacaat 13021 aggtggatat tattgtcaaa taaattcgga acttgcgata gattcagtaa atttctcaag 13081 tagctgatgg taccagattc ttggagagtc acctctactg agtttttcat cttttatttg 13141 ggcaagagaa gcctacgaaa aaagtagact acaagaaata gttgatgtag tctactttct 13201 ctttcaaact caacgcttaa cgcgaaatcg ttgtatgagc cagctcctcc gtcacggtgc 13261 aaaccgcact cgaatcccag ctacctttgc cttgtgcttt cgctgcctca tacatttgcg 13321 caaccgtgcc tccaacgaga acaggtactt gctgttcacg tgcggtttgc gcatagagct 13381 gcaaatcttt gtgcatatga tccaaagaaa agaccgtatt ttcatacgta ccatacaaga 13441 tgttaggccc aaatacggag agcacacgat tgtgggcaga gcctttgtcc atgacggctg 13501 ccagcttgtg cggatcaacg cctgcttttg ccccgacagt aaacgcctcg cccaacgctg 13561 ctgtaatgac tgcaacgaca gaattgtgac aaagcttcgc cacttgtgca gagccggatt 13621 cccccagata aaaaatttcc tttccaattg ccctgagata gtccatgatt tccggaagct 13681 tggcctcatc accgccgacc ataatggtca acgttccggc cgcagaaccc gcaggtcccc 13741 cactcaccgg acaatcatag tagtagatcc ctttttctac gccgtgctga ttcagacgtt 13801 ttgctgtagc aggatcgatc gtacttgtat caaatacgaa actgccagcc cctaatgata 13861 agaaaagtcc gtccgcaccc agcatgactt cctcaacaat cgcaggacct ggaagcgaag 13921 tgaaaacgac acgtgctacg ctacccactg cctgtggaga ctcgacgact atcgctcctc 13981 tttccttcgc ccaggctttt gctgctggac ttgggtcata ggcatacacg tggtagcctt 14041 tttgcaacag attgcagacc atccctttac ccattgcacc aatgccgata acaccaatcg 14101 cttccatctt cgctcctcct gctttcccta tacttatggc cgaatataaa ccgtttttgt 14161 ctcgacgtaa aaatcgaacg ctgactcccc ttgctctctc ggacccaatc cagatatctt 14221 tttgccacca aacggaaact gtgattcaaa atgagtcgac ggcatattga catgcgtgac 14281 acctgactga atgcctttga caaattggaa agctttttgc aaatcgtttg taaaaatcgt 14341 ggatgacaag ccgaattcca cctggttcgc cacttgcata gcatgttcga aagaatccac 14401 atcgatcacg gcgatcacag ggccaaaaat ttcttcgttg gcaatcgtca tctcctgcgt 14461 tatgccggta aacaccgtcg gagcaacgaa gtagccctgt gcgagatcat cttctaccag 14521 gcgcttaccc ccgcattcca gtacgccgcc ttcttccatc cccttttgca catagtgaag 14581 atacagattg agctgatgct cgtccactac tggaccgtta tgattgtctg gatcgaaacc 14641 attcccgatt ttcaagccct tcgcccgctc gatcagtttt gcttttactt gttcggctac 14701 ttcgggtaca accaatacgc gactggtccc cgtacaacgt tgtccattat cgaagaatcc 14761 actcagtacg atggaatcga tagcgaggtc gatatcagcg tccgcgagta tgatcgccgg 14821 atttttcccg cccatctccg cctgaatctt gcctcctctg gctccaactg ctctccccaa 14881 ggcaagtccc acttcagaag aacccgtaaa tgaaatccct ttgaccagtg gatgattcgt 14941 taattcttcc ccgattaccg cacccggtcc tgttaccaaa ttcactacgc cactcggaac 15001 gccgctttca atcaggagct ctaccagctt tacgctaatc aaggaggtgt tgcttgctgg 15061 cttgaacaca accgtattgc ctgcgaggat agccgggacg atcttccaca agccaatccc 15121 cagcggaaaa ttccatgggg caatgatcgc gaaaactccg attggctctc gcaccgtgta 15181 accgattacc cgttcatcaa aggaaggcac cgtctgacct gtcaagcgag tggcttcccc 15241 agtcaactgc ttcatagagg taattgtctt ggcaacctcg cctctcgctt cccgcaatgt 15301 ttttcctact tcacgggtga tcgtttctgc gagctcttct ttgtgttttt ccaacaaatg 15361 aatgagggaa aacaagaact ctccacgtgt gggagccgat ttttgcgacc attcaccaaa 15421 agcattggca gcagcttcaa tggcagaacg cgcatccagc ccgtccgatt tttgaaaata 15481 accgagaacc tcattcgtat tggcagggtt cgtgcttgga aaaacttgcc cggtatggct 15541 cgccacccaa gctccagcga tgtagttatt gtaggttact gtcaaatcgt ctcccacctt 15601 ccgtatctta tagaagtatt gtatatagca aaaattatga atacaatgta tacacagaca 15661 cttatttcca actattattg tgtatttctc tacatggagg acacgtggat gaattctttt 15721 tcgctcctgc ttgaaaagct gcataaatgg tttggcgatc agcccttttc cattttgttc 15781 caattttcgc gtgatcgaca ttttcggctt gttttctcct cttttcatga aaacgctgcc 15841 acgaatattc cccctatgac agttcctctc tgtgacaacg atgctagcca catgcgctat 15901 gcatttgagt cccttccctc ccaacagatg taccgttttt tctacgaaaa cgaaggacaa 15961 gccgttattt gccttgcaca tcaagcaaaa ctaccgatca tccttaccgc tgaccaatgg 16021 gaactattgt ggttcgggtt tcgcctgttg ttggcggaag aaaaaatgac tgcaaaaacg 16081 gaggaaagca agaagctttt tgaagggatt cgctccatat ctgctaccct cgacgttcac 16141 caaatcatac gtggcatcat aggaaacgca ctagctgtta tcccggctgc tgacgcaggt 16201 ctcctgcact tgtatgatcc cactatcgat cgattgattc cgaaagcgac ggtcggtttt 16261 catgatacgg tgttcaagga tctcaaaatg cgggttggag aatccatcgc aggcaaagtg 16321 ttcgaagacg gaatcccacg catgtacaaa acgagccaag aaacaaccca tgcgatgaag 16381 gatatctctg ctgacaactt tcactctctg aaccacgcaa aagcattgcg agacttgaat 16441 gggttgttat gtgttccgat atcacgtgaa gaaaagcgta ttggtgtact tgtcctgcat 16501 cagtttcatc aagaaaatgt gtttaccgac tacgacctcg accttctcca aggcttcgca 16561 gaccaaactt ccatcgccct gcaaaatgcg gagctctatg ctgaagtcaa gcaagcgtat 16621 gaacatatgg cttccattag cgctcaactg caagccaagc acgatgattt gatacaacgc 16681 aaccatatac atgaatccat caagcagttg tccttgcaaa ataaaggggc ggaaacaatc 16741 gtaaaaaccc tcagcaaaat gacaggacat tccatctatt ttgccgattg gcttgagcaa 16801 aaaatgtatc ctgaaaagag tgctgtattt tttagctggg atgaactgta tacattgctg 16861 aataaaaaaa gacagcctgt ttcggtcaac ctgtttactc ccgcttccgg tgacgatcaa 16921 ctgttctgtt tatatccact aatcaatggg agtatttttc tcggatgtct catgattccc 16981 ttagacgaac gggggctttc tgatctcgca cgtatgacgg tcgaacaagg gagtgctgtg 17041 ctcatactcg atttggtgaa aaagcaatcg atcagctccg tgctgtataa gcgagcacac 17101 gatctttttc aagagctgat cgcaagcaaa ggaaatgaac tgtttgaccg cgcccgttcg 17161 atggggttac agccgcaagc agagtactac gtgatttatg cccatttgac acagtgccac 17221 gacctggcat tgctagaagc aaacattcac cggctcatta cccgttggaa atgggagttc 17281 agtaagacac agatgcttgt atacggattc cataaccatg tcaccctcct catccggtct 17341 ctcggctccc gagatggaaa ggacatccgg gagaggctgc aacaggcgtc cgatgagtgg 17401 gaacttggca aggaagcatc gttatccatt ggcgtgggaa gcatggcaag cgggattgag 17461 caaattagca aaagctacga agaagccaaa aaagccgcac attatttgac caaccgtggc 17521 cgttctggtg tggtttacta taaagacctg ggtgtcaatc gcctcatgct gaatcagagc 17581 caggccgata ttgatgcatt tattcaagat gtctttgccc ctttctggca agacccggaa 17641 aaatatcagg aatgggaaca gacgatcata acttatatga aatgcagtca atcccctcaa 17701 ctgaccgcca aagaactgca cattcacgtc aatacgctgt atcaacgttt gcgcaaagta 17761 gaggagcttc ttcatatcga tttacgaaat ccggaagact tgctgaaatt acagctcgct 17821 tgtcatttgc gccaggaagg ttaaatcgaa aaagacagga gtagcttcgg acaggaaaaa 17881 gccccaggct accactgcct tttttgttta ccataattaa gttatgtaaa tcagtttcct 17941 tgtgtatttt ctctttgtaa aaattggaaa tcatccataa tgaacatggg ggctccaggc 18001 accaaacacc ccagagattc acgccctact acttgtaaag gagtgatgat gttttggatt 18061 cgcaaaaaca aatagaaaag catatgagag gttccaaacg ataacttcat cccttctctc 18121 atatgctatg ggaggaaatg aacgaaatgt ttgctcaaaa aatggttcaa ggaacggaac 18181 tcacaaccga ttgcttccat agcgcgacca atctgttcga agcgttgaag catcatgtat 18241 ccatcaaagg ggtcattgca ggtgtgattc ctggtagagt attcctgtca aatgacgcga 18301 gatcagcctt gctgacaagt cctcaaggta tttttctagg aggcagtgtt gataatcccc 18361 tcttctttaa agaagtgaat acattgctaa aagaggagct attaccgcag cttgctgctg 18421 atgaacagct tgactacgtc ctgttttatc ctacggatga gaagtgggat gacattctcg 18481 atatcgtaat gaaagatgta ttccccatga gaagcggccg aatgatcttt acgcaccatt 18541 tagaggatct gtcccctctt gctgacgacc atattttccc gataaacagc accttgttga 18601 agcggaaaga attggtaggt cttgaggatg ttatcgatga aatagcagag aattggccat 18661 ccatagaagc ctatgaaaac aaaggcttcg gttgtgccgc gatacaagat accgatgagg 18721 ggccgccaaa caacgcggga tgaaaagagt gggatggcag tgctggtcaa ataatatagg 18781 atcgcagcga acagccttgt ctgtcggttt cgagctgctc gcggatttcc cggttctgtt 18841 cggatggaac cttccgttaa acaatttcct tgtcaacggc aaccactata tgcgtggcga 18901 tctgaaatat ggcgtggaaa aagactatgc ccgcgccgca tggagttatg cccaagcact 18961 tgatgaaggc tgggattgga atggcgatgc ggccttgtat tggaatgctg cttgcctatt 19021 ctatctgagt ggtgaagagg accgggcaaa gcattactat aaaaaggcta tcgagcacgg 19081 ctgggtaagt attcatcacc cgcattatca tgatgatgtg tacagggaac aggacagcga 19141 gcagatcgct cgaattcttg ctgaatcact caaataagtg aaacggccgc cgttttttcg 19201 gcggcttttt gctgagctca acttttccct ctccttctct gcctttgaag gaaaaagaaa 19261 tggtttgccg ttcaagtagt ttttgatcat tggtattgca tagggctgct cttcttttaa 19321 cccctcggtt tccctgtggt caggagcatg atgactataa ttttcatcat gaccatcact 19381 gtgaagctct ctaggatggg gagccattcc ccttctaggt tccgcaagct cttgtagcct 19441 tttatgtcta gcgctctttg ttcaggatat aaccccaaaa tggtatggct tggtgcagat 19501 tgccgtgaat gacaccatag ttgctgctgt tcatgtccaa tttagcaaga caagtgagta 19561 ttttatccgc cgccaattga tatagcacga attcttcatc tgtcagaaac tgctggtaat 19621 gctccctcaa acgagacata gattgcttga agctatcctc tccccaaatc ggacgcgcaa 19681 attcaggggg caattggaaa tcctgagata cagtatgaag ctttgctaat aagacaccct 19741 ctttgtacac ttggtcttcg gtaatttttt catctgcatg ctccccatcc aagtcgtatt 19801 cttgcagcgc cttttgtgcg atttgctggg actgggccac taccttctcg atgtcatctt 19861 cagaattcaa ctgaaatagc ttcgtcatgc gaatcccccc acccaataaa tggatcattc 19921 gcttacattc gtttgatttc ggccgtactt cctcttttta tttttttctc ttgactccaa 19981 cctaaggtca gactgcaaac tcaacttcag gaggtgaatc gccatgttgt ataccgttaa 20041 cgatgtagcc aaactgtctg gtaccacaat caagacactg taccactatc aaaagattgg 20101 tttgctgatg ccagaaatcg ttacagaaaa tgggtaccgc tattacggtg agaacgaact 20161 caagcggtta caacaaatct tgttttatcg tgagcttgat ttgtcattgg acagtattaa 20221 agctgcactt gatcacgaac cagacagact tcgttgctta tgtgagcagc aaacgatgct 20281 aaaggcacgc cagctacgat tggagcgcat tttgaatact ctcgaagaaa cgattcaaca 20341 cgaaaggaag cgaggaaata tgtccacaga aaacatgttt gatggattga acgaagaaga 20401 atggaagcag gcattcactc aacaaaatga gcatttgcag aaagcgtacg attttcaatt 20461 cgatacagag aatctggacg tgacttccct gaatgaaaaa gctgccgaag cgaaggcttt 20521 catgacgttt atggcagacg cgctgaaaaa caacagaagt gtcgacgata aaacagtggt 20581 ttctgcgatc gaaagccatc ttgctttttt acaaaaagac catccgattg atgcgaaagc 20641 ttttgccgag cagtcaagat ttttcctatc agatgagttc caccgcacta tgttggaaga 20701 acagcaaacg ggattaagct actacatttg cattgctgcc gaaaattacg cttccaagta 20761 aagtgtagtt aaacgattgt ttaacagtga aaccgggtga gctgcaactc cccggttcat 20821 tgtttcaatt cctatctaat gccttagatt accgccccga taatatgctc cttgatcagc 20881 atccatcgat cacgaggatt cggcatgaat tccgatgcaa tggctacgac gaggtttttt 20941 tccgggatgc aacagataac attaccgcca tcgcctattg cagcgtatgc aaaaacaccg 21001 tcctcttcac gcaaccacca tagatacccg tattgattgg gattcatagc gattgattca 21061 tctatccaag cctctggaat gatctgatga ttgtcccaac agccacgatt caaatagagc 21121 caaccaaaac gtgccatgtc acggggagtt aacgtgagac cccatcctcc tgtggagttg 21181 ttgtctggat cttttaccca tcctctcaca tctttcccga ataaatcatc agacgcaaac 21241 cacttcattt cataatcagg gatttcttcc atgccgatgg gtgtaaacaa gcgttcgttc 21301 gcgaattctc gggcactttt tcctgtgctg cgtgtgagga tggcggagag caaatgcgcc 21361 ccagcggtcg aatacttaaa cgctccaatc gttccctttt gcccgagcat atccagcgta 21421 tatttgaccc aatcggactg catacacatc ttgtccagag gttcgtgcca gtcctcaaaa 21481 ggataggggg ctgtcatcgt gaggagatgg cgtatggtga ttgcttgttt ttgctcatca 21541 gtatgatcgg gtgcatagtc tgggaaaaat tccagcacct tttggtcgac atttttgata 21601 aaccgttcct ctaaggcaat accaatgagg gcagatagaa tacttttcgt tactgacgct 21661 acatggtttc tatccttcgg tccatagcca tgatagtatt tttcatgtgc gagatagcca 21721 tttctcacaa caacgattcc gtttatgttg ctgtacgcgg attttatgat agggtctagt 21781 tctgctagtt tttcagcgtc aatgttcaag atggccgggt ctgctgcttg ccattctgta 21841 gtgggccaat agcttctttg catgataatt ccctcctcca caaggtaatg tcattttttt 21901 ctgactgaaa aaaacacctc cgtaacaagc tcctcaggaa cgctggcttg atcgggtgcg 21961 gttacataga cttcgtaggg tgatctcacc aattcatagc cttcattttc tacccattcc 22021 ctcagcctgg catataccga tatcaattct gagtaaggac ccttacatac agactttgca 22081 caaagtcccc caggcaaatc tcttgttccc tttacagcct ccgcgaccgg gagtgcaaac 22141 tcggtatcgt ttccggcagg attaaattca gggctgtgat aaatcgtcat tggcgtgccg 22201 agcaaggtga gcttttcagt cgcaatcctt tcatacagct tactaaaata cttgccatat 22261 cctgttgcat aatcatcact cgtcatcatc tggcgtaacg aaagaatatg gatgggctgg 22321 gtctccacaa gctgtacttc tatgttgtca aggtatgcca tcatagggat accctgctcc 22381 attttcgaaa gatcatggtt cagttgtttt atggtatagt ccaaagcatt tcgtttttca 22441 tgcatttccc tttgtttgcg aagaagcgcc gaaacaagct tctcttccga ttgatcttct 22501 tcccattcca ggatggcttt tatttcgtcc agcgaaaaat gatacgattt caaacggttg 22561 atgaagagca tctttttcag ttgcttgatg gaataatacc gatagccatt ttccggatta 22621 at //