LOCUS       NZ_CP018145            23571 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Brevibacillus formosus strain NF2 chromosome, complete genome.
ACCESSION   NZ_CP018145
VERSION     NZ_CP018145.1
KEYWORDS    RefSeq.
SOURCE      Brevibacillus formosus
  ORGANISM  Brevibacillus formosus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Brevibacillus.
REFERENCE   1  (bases 1 to 6437015)
  AUTHORS   Fu,B. and Li,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi
            Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 167.68
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 02:46:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,168
            CDSs (total)                      :: 5,986
            Genes (coding)                    :: 5,821
            CDSs (with protein)               :: 5,821
            Genes (RNA)                       :: 182
            rRNAs                             :: 16, 17, 17 (5S, 16S, 23S)
            complete rRNAs                    :: 16, 17, 17 (5S, 16S, 23S)
            tRNAs                             :: 127
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 165
            CDSs (without protein)            :: 165
            Pseudo Genes (ambiguous residues) :: 0 of 165
            Pseudo Genes (frameshifted)       :: 85 of 165
            Pseudo Genes (incomplete)         :: 95 of 165
            Pseudo Genes (internal stop)      :: 22 of 165
            Pseudo Genes (multiple problems)  :: 35 of 165
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:35:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1773547
            Orig. end                         :: 1797118
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP018145.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23571
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="4"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23571
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23571
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13571](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13571
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    67..76
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(342..355)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.32"
                     /tool="antismash"
     misc_feature    complement(598..611)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.22"
                     /tool="antismash"
     misc_feature    complement(599..614)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.69"
                     /tool="antismash"
     gene            754..975
                     /locus_tag="BP422_RS08895"
                     /old_locus_tag="BP422_08655"
     CDS             754..975
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BP422_RS08895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BP422_08655"
                     /product="hypothetical protein"
                     /protein_id="WP_088907417.1"
                     /transl_table=11
                     /translation="MIQDLSEIFSSQPLIKKILRKKWKRTFMVRASFLQNDPNMPVKLV
                     DELFGEKVKTALGKLPGTVIVDAGYGGI"
     gene            1015..1719
                     /locus_tag="BP422_RS08900"
                     /old_locus_tag="BP422_08660"
     CDS             1015..1719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419822.1"
                     /locus_tag="BP422_RS08900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08660"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_088907418.1"
                     /transl_table=11
                     /translation="MIRQNLEIGNIPAILWGDKSDKLFIVVHGNMSNKADDSIIVFAEE
                     ATAVGYQVLSFDLPQHGERKDDTYLCKVQNCVRDLNKIMTYAKSLSNHISIFACSMGVY
                     FSLLEYCHEPLNQCLFLSPVVNMERIIDNMMTWFNVSESRLKIEKEISTPIGQTLYWDY
                     YCYVKEHPIVAWNNPTSILYGSGDNLCEFDIVSEFAKRFNCNLQVMENGEHYFHTQEQL
                     QYFRQWLKKHIY"
     misc_feature    complement(1842..1857)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.95"
                     /tool="antismash"
     misc_feature    1845..1860
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: strong, score: 26.61"
                     /tool="antismash"
     misc_feature    1847..1861
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.0"
                     /tool="antismash"
     misc_feature    1848..1861
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.06"
                     /tool="antismash"
     misc_feature    1886..1904
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.83"
                     /tool="antismash"
     gene            1888..3513
                     /gene="nikA"
                     /locus_tag="BP422_RS08905"
                     /old_locus_tag="BP422_08665"
     CDS             1888..3513
                     /EC_number="7.2.2.-"
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikA"
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013919971.1"
                     /locus_tag="BP422_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08665"
                     /product="nickel ABC transporter substrate-binding protein"
                     /protein_id="WP_088907419.1"
                     /transl_table=11
                     /translation="MFGSTKKAVLLMVAVILLLSTTLLGCTKQETESNGENKAASAEKV
                     ITLSWPRDIGPMNPHTYNPSQLFAQSMIYEPLVSYKEGGKLEPYLAESWSISKDGKEYT
                     FKLRQNVKFSDGTPFNAAIVKKNFDAVMKNPKLHSWLGVINALDKTEVVDEQTFKMTLK
                     EPYYPTLQDLALVRPVRFLGEAGFPDDGDTSKGLKKPIGTGPWMLADYKKDEYAVFTRN
                     PNYWGESPKIDKVTVKIIPDAETRVMAFEKGELDLIYGEGVISMDSFNQLKESGKYVTE
                     LSDPVGTRSLLLNTSNEKLADLRVRMALQHGFNKQAMVEGITLGLEEKADNILSKNFPY
                     TNMDVQQVEYNVEKANAYLDEAGWKLPAGKTVREKDGQPLELELIYDKTDPIQKAMAET
                     MQAEWGAIGVKLNITGLELTVQIKRRKAGEFDLDFWYNYGAPYDPHSFINVVAEKGWGV
                     SEAHSRLSMKQELDQQIKDTLASTDEAKREQLYDSILRTLQEQSAIVPVSYIKKTVVYQ
                     KNVKDFSFPANRDEHPFYGIGISK"
     gene            3532..4477
                     /gene="nikB"
                     /locus_tag="BP422_RS08910"
                     /old_locus_tag="BP422_08670"
                     /pseudo=""
     CDS             3532..4477
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikB"
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373739.1"
                     /locus_tag="BP422_RS08910"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08670"
                     /product="nickel ABC transporter permease subunit NikB"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVSYIGKRALAIIPIVLFAILITFVLIHISPVDPAEAYLTAAHIH
                     PTEELLAEKRHEFGLDQPLIVQYFQTVMKICRLDFGRSYITNEPVWDEVTARMPATIQL
                     AVSSILFAMIVSIPLGFFVSGL"
     gene            4474..5307
                     /gene="nikC"
                     /locus_tag="BP422_RS08915"
                     /old_locus_tag="BP422_08675"
     CDS             4474..5307
                     /EC_number="7.2.2.11"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikC"
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003183802.1"
                     /locus_tag="BP422_RS08915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08675"
                     /product="nickel ABC transporter permease subunit NikC"
                     /protein_id="WP_088907420.1"
                     /transl_table=11
                     /translation="MIPHIRTVLKGQKTITVCSVILLVFAIITVLAPWISPHDPIKVNV
                     AMKLKPPCTEHLLGTDHLGRDNLSRLLHGARISLGFAFLIFVSSIGIGLIVGTIAGYKG
                     GWIDTVLMRFCEGVMAFPNLVLVLGIVGVFGPGLIQVVLALMLVQWVYYARMFRSMVVS
                     LKERNFIIAARISGSSQWKIIKQHMIPNILPPILVMGTLEMGWAIMDISALSFLGLGIQ
                     PPTPEWGAMIHEGKGFIRSHPELMLYPGLMILFVVITFNVLGEALSERFGVKRRF"
     gene            5326..6150
                     /gene="nikD"
                     /locus_tag="BP422_RS08920"
                     /old_locus_tag="BP422_08680"
     CDS             5326..6150
                     /EC_number="7.2.2.-"
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikD"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691684.1"
                     /locus_tag="BP422_RS08920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08680"
                     /product="nickel import ATP-binding protein NikD"
                     /protein_id="WP_088907421.1"
                     /transl_table=11
                     /translation="MEEPRKVLQVSGLHVKVKAEQGMLSLIQDIHFDLKRGQVLGLVGE
                     SGSGKTVTCNSLLQLLDQKNTIVEGSIQLNGRELNGLKAEEMRRIRGKEIAFIMQNPMS
                     AFTPVYTIGMQFIETIRTHTMLTKKQAIELAVTSMEDVNLPDPPKLMNLYPFQLSGGML
                     QRVMIAISICLRPSVVIADEPTTALDVVNQLQVLRQLDRLRLEYGTSIMLISHDLGVIS
                     ELADEVAVMQHGRIVEQANVFKLFDHPQHAYTKKLLNARPAFPLHQLNRESV"
     gene            6213..7031
                     /gene="nikE"
                     /locus_tag="BP422_RS08925"
                     /old_locus_tag="BP422_08685"
     CDS             6213..7031
                     /EC_number="7.2.2.11"
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007433071.1"
                     /locus_tag="BP422_RS08925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08685"
                     /product="nickel import ATP-binding protein NikE"
                     /protein_id="WP_088907422.1"
                     /transl_table=11
                     /translation="MLLQVKDVTHSYGVPRLFWRSDRRVPVLSDISLTIEQGMCLGLLG
                     TSGAGKSTLGKVILGLEKPRQGQVFFQGHDLYRTDIQTRKALRRDLQVVFQDCYSSVNP
                     RMTAERIIGEPLDNYESLSLNEQKRKIGELLEMVGLNPEDMRKYPNQFSGGQLQRINIA
                     RAIALKPKMIVLDESVSSLDMVNQTHILGLLRELKSVFGLSYLFITHDIKAAYSICDGL
                     AVLEKGELVEMCDDKDQIFASSHATVRSLISSILSEHPRHRSLSSDEDPY"
     gene            7731..7922
                     /locus_tag="BP422_RS08935"
     CDS             7731..7922
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BP422_RS08935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_236841331.1"
                     /transl_table=11
                     /translation="MKRRLFAGDVDVVDVVVAAADVVVAVVPVLAPASVAVPASAHAAA
                     LASSHALSYEWRYLLTIN"
     aSDomain        8061..8357
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BP422_RS08940_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="1.00E-42"
                     /identifier="RREFam011.1"
                     /label="BP422_RS08940"
                     /locus_tag="BP422_RS08940"
                     /protein_end="99"
                     /protein_start="0"
                     /score="135.0"
                     /tool="antismash"
                     /translation="MVRLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERW
                     VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQDISREKPHELS"
     gene            8061..10004
                     /locus_tag="BP422_RS08940"
                     /old_locus_tag="BP422_08700"
     CDS             8061..10004
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717950.1"
                     /locus_tag="BP422_RS08940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08700"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_088907425.1"
                     /sec_met_domain="TIGR03693 (E-value: 3.2e-182, bitscore:
                     605.5, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2.1e-40, bitscore: 135.0, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.4e-12,
                     bitscore: 45.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERW
                     VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQDISREKPHELSPEIIS
                     AYAEQIEFLDQFGGSGGYLFQKYRAEKVLIVGAGSFLLSVVHALLESGCVQFHYVIANE
                     TPTNRERLDAIIEHARRKDPHVKLEELKPASWGIAEWSEAIEPFAAILYTSAQVNKDEM
                     SVIHSACREREKVFVPAVCLMQKGIAGPLIHPESAACLESAWRRLHRQTLCADPDLHPF
                     SMTAAAILANIAVFEWFKHVTGVNEAEDENKVYVLNLETLEGSWRSFLPHPLVNKEMSL
                     EVLNSKELESRLSNKTEPKEGLQSLFQSWTSSDTGIFHSWDEGELTQLPLTQCMVTAVD
                     PVSEGPAELMPQVVCPGYTHEEARREAGLLGAEMYVGRMVKHLVTIDTDFRAMGNGNMG
                     VGAGETPAEGLNRALRHCLTLMYVSEMKGRQPTARPVYADTIADEPCQFYIRSFTTLGE
                     KPTIAKGYEVYGFPVYWVGTRTGWYGSIGLQERDALRSALMYALQQIQTPTTQVSKYVL
                     TAQSVGLAGEAIEVALNSVQEESEKEVWKQAAEVLALHHLSPLVMNAAVEPFLEEDLGG
                     VFALLLSQEVPR"
     aSDomain        8082..8324
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BP422_RS08940_Thiopeptide_F_RRE.1"
                     /evalue="1.10E-14"
                     /identifier="RREFam004.1"
                     /label="BP422_RS08940"
                     /locus_tag="BP422_RS08940"
                     /protein_end="88"
                     /protein_start="7"
                     /score="45.1"
                     /tool="antismash"
                     /translation="MRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERWVDQLMPM
                     FNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQ"
     gene            10001..11941
                     /locus_tag="BP422_RS08945"
                     /old_locus_tag="BP422_08705"
     CDS             10001..11941
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016740499.1"
                     /locus_tag="BP422_RS08945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08705"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_088907426.1"
                     /sec_met_domain="TIGR03882 (E-value: 2.3e-47, bitscore:
                     159.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.8e-75, bitscore: 253.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4.3e-122, bitscore:
                     406.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADILIIGDGVLAELVSERLRKDYRVWHSENMESATSGADLALL
                     LHDTYRPALHLQAENNFRQANIPWLRGFVSFGEAIVGPLVRPGQTGCSQCADMRRLMAG
                     RDRKEMWKVQHMLSEKGGILRDPWASRSGLLQVAYHVSAEVDRIVEGRQAQLSEHIQFI
                     DLQTLTSTRHFFLLNPLCPVCSQLPEDSEEQTRIRLKPIIKQSPDSYRTKSIADLKQAL
                     STEFLDSRTGFLNGKVRDLVSVFADVSVNLPLFSHDEGTAGRSVSYADSEITAILEGME
                     RYCGLMPRGKRTMVRDCYANLAPHALDPTTVGTHSEEQYALPDFPFQPFDPKREMNWVW
                     GYSFKEERPILVPELMAYYSMGFGEGVVFESSNGCALGGSLEEAIFYGILEVVERDAFL
                     LTWYAQLPLPRLDPATVNDRELLLLIDRMQTVTNYDLYLFDATMENGIPAVWTIAKNRG
                     AEGLHLVCAAGAHPDPIRAVKSSIYETAAMLMPLTDKYEANRDKYLRMLQDSSLVKKMD
                     DHAMLYSLPEASERLSFLMDDSRPMVSFAEQFPRRNQNRDLTDDLRELLGVFQKLDLDV
                     IVVDQTTPEVGRHGLSCVRVLIPGMLPMTFGHHLTRVTGLKRVLEVPVKLGYAKQPLRV
                     DELNPFPHPFP"
     gene            11964..13571
                     /locus_tag="BP422_RS08950"
                     /old_locus_tag="BP422_08710"
     CDS             11964..13571
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248326.1"
                     /locus_tag="BP422_RS08950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08710"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_088907427.1"
                     /sec_met_domain="PF00881 (E-value: 2.6e-06, bitscore: 26.0,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLENFLYRLHFDTENARSSDLEVDWGDAPLTYKVYRGLPVIPLP
                     EDVPLSLVDQTVSQEMSLSQLGAWLWYSYGLIQISQSLLTTTSADAESESFLPLVTNRR
                     PVPSGGGLYPSELYVYLKLSSIPPGLYHYDVAHHRLVQLREGNFDHVLSRALGGSCPVH
                     ACFGVAFVSIYFWKNFFKYDEFSYRLQGLDAGVLLGQLQEMANQFGVTTAVHYQYLDKA
                     INKLLGLSADQESVYAVVPLSLQEEGERHSHSPALWTERGDETASEVIRELPEQKHMHV
                     IRSKRMRQYPALLQMNEAAMQESTHAFRRYSDQLESKWSRRFDERILLPRLQKPSYDLA
                     QYCRERFSPEMDFIRKKTDQNQVARIMEMTMSALSYGNDLGNNQEAAWGRLSLFVSIHQ
                     VEGIQDGAYAYKPLEHALYPIVYGDLRARLQDGMTLDNVNLYQGPLCFHVAGKRDHLIN
                     QLGFRGYRIQQMEAGIVVHRLLLAAFTCGMGGHPLLGFDVENCDDLYNLETEEKTCLIQ
                     IPVGHYRPRARFQTGLHG"
     gene            complement(13612..14826)
                     /locus_tag="BP422_RS08955"
                     /old_locus_tag="BP422_08715"
     CDS             complement(13612..14826)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (20-394). E-value: 2.6e-67.
                     Score: 219.2. Matches aSDomain:
                     nrpspksdomains_BP422_RS08955_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01976.1"
                     /locus_tag="BP422_RS08955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08715"
                     /product="cysteine desulfurase-like protein"
                     /protein_id="WP_236841437.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-64, bitscore:
                     216.6, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.4e-05, bitscore:
                     21.3, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.7e-08,
                     bitscore: 30.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVREQFPALQRTYKGKPVVYLDGPGGSQVVKSSMDAIYRYMAN
                     GGANLHGSFPTSKETEAILADAKQAVADLFHVRPLEVAFGANMTTLTFAIARALGRHWK
                     EGDEIIVSEMDHRANVDPWLTVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLLA
                     VGLASNAVGTIHDLAAISQKARTKGVVVAVDAVHAVPHFSIHRDEIGADILLCSAYKFF
                     GPHVGIAVIRKEIFEALDVYKLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFIASLGLG
                     ESFAEKIRSGYEVIEAYENQLAEKLRKDLDAMKGVTLYQADEDAPKTPTIAFRIEGFSP
                     QEICERLCEEHSIFVADGDFYATTLANCLGINESGGWIRAGLAPYNTHEEIDRFVQGIK
                     AVIRA"
     aSDomain        complement(13645..14766)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BP422_RS08955_Aminotran_5.1"
                     /evalue="2.60E-67"
                     /label="BP422_RS08955_Aminotran_5.1"
                     /locus_tag="BP422_RS08955"
                     /protein_end="394"
                     /protein_start="20"
                     /score="219.2"
                     /tool="antismash"
                     /translation="VYLDGPGGSQVVKSSMDAIYRYMANGGANLHGSFPTSKETEAILA
                     DAKQAVADLFHVRPLEVAFGANMTTLTFAIARALGRHWKEGDEIIVSEMDHRANVDPWL
                     TVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLLAVGLASNAVGTIHDLAAISQK
                     ARTKGVVVAVDAVHAVPHFSIHRDEIGADILLCSAYKFFGPHVGIAVIRKEIFEALDVY
                     KLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFIASLGLGESFAEKIRSGYEVIEAYENQ
                     LAEKLRKDLDAMKGVTLYQADEDAPKTPTIAFRIEGFSPQEICERLCEEHSIFVADGDF
                     YATTLANCLGINESGGWIRAGLAPYNTHEEIDRF"
     gene            complement(<14839..15357)
                     /locus_tag="BP422_RS31990"
                     /pseudo=""
     CDS             complement(<14839..15357)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140152.1"
                     /locus_tag="BP422_RS31990"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTTLNTALVRIQPWADHDLSLLRLLNGSAMMEHLGGPETEEQLL
                     ARHERYVNKDGQLTSKMFSIVLLPDHTPVGSIGYWDRIWQGENIYEVGWSVLPPFQGKG
                     IASMALASLITRINQERRHKYIHAYPSVDNPASNAICRKLGFTLQSECVFEYPPGSFMR
                     SNDWRLEVAS"
     gene            15636..16148
                     /locus_tag="BP422_RS08960"
                     /old_locus_tag="BP422_08720"
     CDS             15636..16148
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891003.1"
                     /locus_tag="BP422_RS08960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08720"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_088907429.1"
                     /transl_table=11
                     /translation="MNEKSIQTQRLILIPFTHRIATNILQENYEELLDLGLTLGKGWPD
                     EDAMETIPKIIKALELTGEPTGFESWMIITQDGMKIIGDVGFKGVPNAQGEVDIGYGII
                     EAERKKGYAYEAAKSLANWALLQPHVKKITAKCLLDNIDSAKLLVKMGFTEIKRDDTII
                     YWSRQKE"
     gene            complement(16224..17048)
                     /locus_tag="BP422_RS08965"
                     /old_locus_tag="BP422_08725"
     CDS             complement(16224..17048)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016740503.1"
                     /locus_tag="BP422_RS08965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08725"
                     /product="hypothetical protein"
                     /protein_id="WP_088907430.1"
                     /transl_table=11
                     /translation="MFRKIVHSLVCLLLVMTAGAVNVNAAEAKATGMFFIDKPLKKEGL
                     RFQVTVTEIDNPKYDSPTYHVNTIVTNISRKPITYTTGHCYGVTTRLEAYASGDSWELP
                     YPENEPVCPPVIQEKTLKPGRTIEQDEYFRTDELPDDLTPDYFQLNSSVHILVGPEDER
                     KEEFVKMQTKLLPGLALNPDEIEIQSESSKLPKSYYELKVTGKASNKDIKSVTIQVFNT
                     IITLRIDSKSGEFSTKKKVKAKGPSLQSGVLEVTYKDGTKHIYNIPIENSSN"
     misc_feature    17151..17164
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.06"
                     /tool="antismash"
     gene            17303..17914
                     /locus_tag="BP422_RS08970"
                     /old_locus_tag="BP422_08730"
     CDS             17303..17914
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717970.1"
                     /locus_tag="BP422_RS08970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08730"
                     /product="DedA family protein"
                     /protein_id="WP_088907431.1"
                     /transl_table=11
                     /translation="MQNWMTQIIEQYSYFGILLMMALENIFPPIPSEVILTFGGFMTTQ
                     SSLTVFGVILSATIGSVIGAIILYGIGYYLDVKKIEKIVARWGHILRIKPADIHKANEW
                     FDRYGYWTIFFCRMVPLIRSLISIPAGMTKMNFPLFLLFTTLGTFIWNIVLVMAGHLLG
                     ESWEDILYYFDLYSNVVYAVLAFAGIAFLIFFLRKRKADA"
     gene            18052..19482
                     /locus_tag="BP422_RS08975"
                     /old_locus_tag="BP422_08735"
     CDS             18052..19482
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009335780.1"
                     /locus_tag="BP422_RS08975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08735"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_236841332.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 6.2e-33, bitscore:
                     112.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWAPPLFFRLGEMQLDRFVTRKRRSYYHRQRPSGCTHHCILPGF
                     VDAHGHGGHSLFKTIATDNINDWMSIMTNTYKHYVTDDFWYYEGKLSALERLKAGITTG
                     VSVLGSMPRSDDPIFALNHAKAYNEVGVREIVATGPCNPPWPHPFSRWVDGQKVTKEVS
                     YEQVLAGAEAVIEALNHANNDKTRAYITPFVIVTSVNPSYPTPADQLFGLTDFDRYQAR
                     KIREIAKKYDTRIHSDAFGGMIHLAIQDKEYALLGPDVHLQHCRGISFDEAKILAETGT
                     NVSASPGFGQINARTPITELLEMGATVAITTDGTSPMTPFDMFQAMRRMQLLQQAALRD
                     YYYLPPGKLLEMVTIDAARCVGWDDELGSIEAGKKADVITVNMHQAHLNPENMHVHRVV
                     YQAVGGDVNHVIVDGELIMDERRVLTVDEKQILKQANEEANRTIARAGLEVYMQPSKYF
                     WGHARAYLDERRFDPTKL"
     gene            19671..20513
                     /locus_tag="BP422_RS08980"
                     /old_locus_tag="BP422_08740"
     CDS             19671..20513
                     /EC_number="7.6.2.7"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717977.1"
                     /locus_tag="BP422_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08740"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088907432.1"
                     /transl_table=11
                     /translation="MYLTIDNVTKHFVNEEKQKVKVLDDINLEVEKGSFVSIVGPSGCG
                     KSTLLYLIAGLDQPDSGDIHVAGNKVNKPGPDRVVVFQEAGLFPWLTVLENVTYGLKLK
                     KMSTAKANEKALEVLKMVHLSKYVHSYPHQLSGGMKQRVAIARALVMEPDILLMDEPFS
                     ALDEQTRMVLHKELLEIWRTTKVTIFFVTHNIREAVQLAERIVVFATRPGKIKEIIAVP
                     AMRDGVMPDSVTVNTEQKVLSILQEEIEKVLKEEMGNDYSFKTGHLHRYDSGDMGSHI"
     gene            20446..21201
                     /locus_tag="BP422_RS08985"
                     /old_locus_tag="BP422_08745"
     CDS             20446..21201
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020372021.1"
                     /locus_tag="BP422_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08745"
                     /product="ABC transporter permease"
                     /protein_id="WP_088907433.1"
                     /transl_table=11
                     /translation="MTTALRRVIFIAMIAAIWEVTSKLSGLPSFMFPSLTQVFETLVNG
                     LISGQITAAIGKSMGRILLGFLIAIIVGLILGYFIWRYKLVEDTLGFVVTALQSIPSIV
                     WFPLAIIWFGLNDFSILFIVTIGATWTMTVNATSGFKNVPPLYQRVARTYGSTGFHFVR
                     TVILPASVPQIISGLRIAWAFSWRALMAGELLGGGGGLGQLLEMGRSLGQMDLVISVMI
                     IIAIIGTIVDNVVFSRIERNVQMKWGVHS"
     gene            21233..22228
                     /locus_tag="BP422_RS08990"
                     /old_locus_tag="BP422_08750"
     CDS             21233..22228
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0042918 - alkanesulfonate transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717982.1"
                     /locus_tag="BP422_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08750"
                     /product="aliphatic sulfonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_088907434.1"
                     /transl_table=11
                     /translation="MFKKVFSTVVASLLLMGIASGCSTGGAESSEKEVRIGYFPNLTHS
                     ATIIALEKGYFKEAFGADMKIQTKTVTNGGLFMEAMATKAIDVGTVGPGPLLNFYVKHP
                     GYRLISGAVNGGAVLVMNGSTNITELKDLKGKKIAIPVIGSTQDVMLRKALNEVGLKPT
                     TNGGDVELYAAAPADTAALFVQKSVDGAATQEPWGYVLENQAGGKLLLDWDQFAWGKES
                     TNTVVAASDEFLKREGLATAYLQAHKKAVKFIQENPEESQDLIIKHLKNLTGKELSKKE
                     VQAAFSRLEVTTAVNEKVIQEMADISQEAGYISSNKIDGLIDLKYLEAAK"
     gene            22308..23168
                     /gene="kynA"
                     /locus_tag="BP422_RS08995"
                     /old_locus_tag="BP422_08755"
     CDS             22308..23168
                     /EC_number="1.13.11.11"
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /gene="kynA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891010.1"
                     /locus_tag="BP422_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BP422_08755"
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="WP_088907435.1"
                     /transl_table=11
                     /translation="MRPNEQGSNQPNDTSLETQIHTDFQQEMTYGDYLQLDQILSSQQR
                     QSTHHDEMLFIIIHQVSELWMKQILHELSAANECICNHDLEPAFKMFARVSRIQQQLIK
                     SWDVLSTLTPADYLQFRDKLGHSSGFQSYQNRLIEFTLGYKNQHVLAVYAHQPELHAKM
                     SAALQQPSIYDAAIREMAARGLPIDPECLNRDWSQPYQPNQSVEQAWLTVYRNVNQYWD
                     LYELAEKLVDIASQQQQWRFNHMTTVERIIGQKPGTGGSSGVMYLRRALDHRFFPELWS
                     LRTLL"
     misc_feature    complement(23296..23309)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    23296..23309
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.31"
                     /tool="antismash"
ORIGIN
        1 cgatttttgg cttggtggcc cttgtcttgg caacaccgtt ggctgctatt atgggttttc
       61 tcggactgtt tttttatgtc gtgccttata cgatgtggac aaaaagaaga accgtttaca
      121 atacggaggt aggaagtatt tctggggcaa tgccgccgct catcggttgg gctgccattc
      181 acccggatat cacgcatcct gctatccttg gacttttcat catcatggtc atttggcaaa
      241 tgcctcactt ctatgcgatt gcgattcgca agcatgatga gtacaaggca gctggggttc
      301 ctatgttgcc tgtggtcaaa ggtgcaagac gtacctatat tcaaacaaat gtttatttgg
      361 ttattttaat cgcaagcagt tttctatttt ggtcattaag cgctggtctt acgtttatgg
      421 ctctgctcct gaatgtttta tggctggttc tgagtgtttt tggataccgg aaaatggatt
      481 cacagaaatg gtctaaaacg atgtttattt attcgctgat tcatatgacg gtgctgttct
      541 caacggtgat tatttactcg ctgatgggga ttattttcaa gttgtagaga tgaatgctga
      601 taataattat ttttccagtt aagcatgtta aaaatttgta tataattatc ggttgatgta
      661 gatttggaaa atattataat atgaaaatta gatgacccga ctagtatctc atcggtgtca
      721 tttttttttg cttgaaaaga gtaaaaataa aatatgattc aggacttgtc agagattttc
      781 agttcccagc ctttgataaa gaaaatcctg cgcaaaaagt ggaaacgaac cttcatggtg
      841 agagcatcct ttttgcagaa cgatccgaac atgccagtaa aattagtaga cgagttattt
      901 ggtgaaaagg ttaaaactgc tttaggaaaa ttaccgggaa ccgtcattgt ggacgctgga
      961 tacggcggga tttaggaatc atgaattatt tatatttcat ggaggataga tgtaatgata
     1021 agacaaaatt tagagatagg aaatattcca gcaattttgt ggggggacaa atcagataag
     1081 ttatttatag tagtgcatgg taacatgtca aataaggcag atgactcgat tattgtattt
     1141 gcagaagaag cgacagcagt aggttatcaa gttcttagtt ttgatttgcc tcaacatggt
     1201 gaacgtaaag atgatactta tctttgtaaa gttcaaaact gtgttcgaga ccttaataaa
     1261 attatgacat atgcaaaatc gttatcaaat catataagca tttttgcttg tagcatggga
     1321 gtatatttca gcctattaga atattgccat gagccattga atcagtgttt gtttctctct
     1381 cctgtggtaa atatggaacg tataatagat aatatgatga cgtggtttaa cgtaagtgag
     1441 agtagactaa aaatagagaa agaaatttcc acacctattg gacaaactct ctattgggat
     1501 tactactgtt atgtgaaaga acatcctatt gtagcttgga ataatccgac ttcaattctc
     1561 tatggttcag gagataactt atgtgagttt gacattgtat ctgaatttgc taaacgcttt
     1621 aactgtaatt tgcaagtaat ggagaatgga gaacactatt tccatactca ggaacaattg
     1681 cagtatttca gacaatggct aaaaaagcat atatactaaa tgattaaggg aagtcaaaat
     1741 ggtttccctt aaaagttaaa taatttcaac attattttaa gtcaatcgaa atataaaaat
     1801 cttttctgtt gacataaaat gtgcccttca ctattataaa cgtaaatgat aatcattatt
     1861 aacatacaag aatggagata ccactttatg tttggatcaa ctaagaaggc cgttttattg
     1921 atggtagctg ttattctact cttatcaaca actctattgg ggtgcacgaa acaggaaaca
     1981 gagtcaaatg gtgaaaacaa ggcggcgtca gcggaaaagg taatcacttt atcttggccg
     2041 agggatatcg gaccgatgaa tcctcataca tataaccctt cacaattatt tgctcaatcg
     2101 atgatctatg aaccgttggt tagctataag gaagggggca aacttgaacc ctatcttgca
     2161 gaatcatggt cgatctcgaa ggatggcaaa gagtatacct tcaagctccg tcaaaatgta
     2221 aaattttcgg acggaacccc gtttaacgca gctattgtga aaaaaaactt tgatgctgta
     2281 atgaagaacc caaaattgca tagttggctt ggcgttatta atgctcttga caagacagag
     2341 gtagtggacg agcaaacttt caaaatgact ttaaaggaac cctattaccc tacattgcag
     2401 gatttggcac tagtccgtcc ggttcgattc ctgggtgaag cgggtttccc ggatgacggc
     2461 gacacttcca agggcttaaa aaagccgatt gggaccggac cgtggatgct ggccgattac
     2521 aagaaagacg aatatgccgt gtttacccga aacccaaatt actggggcga gagtccaaag
     2581 attgataaag taaccgtaaa gatcattccc gatgcagaga cgcgcgtaat ggcttttgaa
     2641 aaaggtgagc tggatttgat ctatggtgaa ggagtcatca gcatggattc ctttaatcaa
     2701 ctgaaagaat cgggaaaata tgtgacggag ttatccgacc ctgtcggaac gagaagcttg
     2761 cttttgaata cctccaatga aaagctagct gacctgaggg tacgcatggc cctccagcac
     2821 ggatttaaca agcaagcaat ggtggaaggc atcacgctag gtctggagga gaaggcggac
     2881 aacatcttgt ccaaaaactt cccgtacacc aatatggatg tccaacaggt cgaatacaat
     2941 gtggagaaag cgaatgctta tcttgatgaa gccggatgga agcttcccgc aggcaaaact
     3001 gtacgggaga aggacggtca accgcttgag ttggaattga tctatgataa gaccgacccc
     3061 attcaaaaag cgatggcgga aaccatgcaa gccgagtggg gagcgattgg tgttaaactt
     3121 aacattacgg gtcttgaatt gacggttcaa attaaacgcc ggaaagcagg cgagtttgac
     3181 ttggatttct ggtacaacta tggagcgcca tatgatccgc actcgttcat taatgttgtg
     3241 gcagaaaaag gatggggcgt ttcggaagca cattcgcgct tgtctatgaa acaagaatta
     3301 gatcaacaaa taaaagatac ccttgcctca acggatgagg caaagcgcga acagctttac
     3361 gactccattt tgagaacttt gcaggagcag tcagctatcg ttccggtgtc ttacatcaag
     3421 aaaactgttg tttaccagaa aaatgtgaaa gactttagct tcccggcgaa tagggatgaa
     3481 catccattct acgggattgg tatcagcaag taatcggcag ggaggcaact catggtcagc
     3541 tatatcggga agagagctct cgctatcatt ccaattgttc tctttgccat tctcatcacg
     3601 tttgtactca tccatatctc accggtggac ccggctgagg cttatttaac cgcagcccat
     3661 attcatccga ctgaggagtt attggctgag aaaagacatg aatttggctt ggatcagcct
     3721 ttgatcgtac aatattttca aactgtcatg aagatttgcc gacttgattt cggcagatct
     3781 tatataacga atgagccggt ttgggatgag gttacggccc ggatgcctgc gaccattcaa
     3841 ctcgccgtca gcagcatttt gttcgccatg attgttagta taccgctcgg tttttttgtc
     3901 agcggtttat aaaaacagcc tgattgataa tttcagcagg ctgctctctt ttttcggcgc
     3961 ttccattccg caattttggc ttgggtactt attgattttt ttcttttccg tcaaactgga
     4021 ctggcttccg gtagaaggaa gagggtcgtg ggagcatcta gtgcttccga ccatgacgtt
     4081 gtcgttggca atgatcgcga tctatacccg tcttctgcgc gcgagtgtgt tggaacaatt
     4141 gcaggagtcg tatgtcttat atgccaggac tcggggcatt aaagaaaaag tcattatggt
     4201 gaagcatgtg ttgaaaattg ccatttcacc ggtgattacc ggtttgggca tgaatttcgg
     4261 caaattgctc acgggaacca ttatcgtgga gcaagttttt tcctggccgg ggttcggacg
     4321 ctattttgtc gaggcgattt ttaatcggga tattcctgtt atccaatgct acgtattcct
     4381 cgcagcctgt ttgttcatcg tgtgcaacct gattgttgat cttgtccagc tgtatatgga
     4441 tccccgaatt tctttgaaag gaagaaccga ccagtgattc cgcatatacg gaccgttctc
     4501 aagggacaga aaaccataac ggtatgctcg gtcatattac tggttttcgc cattattacc
     4561 gttttggctc catggatttc acctcatgat ccaattaaag tgaatgtagc gatgaagttg
     4621 aagccgcctt gcaccgagca tttgctgggt acagaccatt tgggacgtga caatctttct
     4681 cgtcttctgc atggagcccg catatcgctg gggtttgcct tcttgatttt cgtttcctcg
     4741 ataggaatag gcttgatcgt cggaaccatt gccggttaca aaggcggttg gattgataca
     4801 gtactgatgc ggttttgcga aggggtcatg gcgtttccga atcttgtgct ggttttgggg
     4861 attgtcggag tgtttggacc tggattgata caggtagttt tggcgttgat gctggtgcaa
     4921 tgggtatact atgcccggat gttccgaagc atggtcgtca gcttgaagga acgcaatttt
     4981 attatcgcag cccgaattag cggctcttca caatggaaaa ttatcaagca gcacatgatc
     5041 cccaatatac tgcctccgat tctcgtgatg ggtacattgg aaatgggatg ggctatcatg
     5101 gacatctctg cgctgtcgtt tttgggcttg ggcattcagc ccccaacacc tgaatggggg
     5161 gcaatgatcc acgaaggaaa aggctttata cgaagtcatc cggaattaat gctgtatccg
     5221 ggactgatga ttttgtttgt cgtgattaca ttcaatgtac taggggaagc tttgtcggaa
     5281 cgatttgggg taaaacgacg tttttgaatg ggaatgaggc cagtgatgga agaaccacgc
     5341 aaagtattgc aggtgagcgg tctgcatgtc aaggtaaagg cagagcaggg aatgctttct
     5401 ctgattcagg atattcattt tgatttgaaa cgcggtcaag tgctcggcct tgtgggcgag
     5461 agcggcagcg gcaagactgt cacctgcaac tccctcctgc aacttctgga ccagaaaaat
     5521 accatcgtag aaggcagtat tcaattgaat ggccgagagc tgaacggctt aaaagcagag
     5581 gagatgcgac gtatacgcgg gaaagaaatc gccttcatta tgcaaaatcc gatgagtgcc
     5641 tttacaccgg tgtatacgat aggtatgcaa ttcattgaaa cgattcgtac ccataccatg
     5701 ctcacaaaaa aacaagcaat cgagctggcg gtcacttcca tggaagatgt gaatttgcct
     5761 gatcccccca agctgatgaa cttgtacccc tttcaattga gcgggggaat gctgcaacgg
     5821 gtgatgattg ccatttccat atgcctgcga ccatctgtcg tgattgccga tgagccgact
     5881 acagcgctgg acgtggtgaa tcaattgcaa gtgttgaggc agctggaccg attgcgcttg
     5941 gaatacggca catcgattat gctgatttcc catgacttgg gtgtcatttc ggaattggct
     6001 gacgaagtcg cagtgatgca gcatggacgg atcgtagagc aggcgaatgt ctttaagctg
     6061 ttcgatcatc ctcagcatgc gtatacgaaa aaactgctga atgccagacc agcctttcct
     6121 ttacatcagt tgaataggga atctgtttaa ttattttctc ctgcatagtt ttgctgtcta
     6181 ttctatgaaa aacggaaaca gggggtgagc gcatgctgct tcaggtaaaa gacgtaaccc
     6241 attcttatgg cgtaccgagg ctgttttggc ggtcagatcg acgagtgccc gtcctctccg
     6301 acatttctct tacgattgaa caaggaatgt gtctgggtct actgggaacc agcggtgcag
     6361 gaaaaagtac attgggcaaa gtgattctgg gcttggaaaa acctcgacag ggacaggttt
     6421 tttttcaagg tcacgatctg tatcgcacgg atatacaaac tcgtaaagcg ttgcgacggg
     6481 atcttcaagt cgtgtttcaa gattgctact catcggtaaa tccacggatg acggccgaac
     6541 ggattatcgg ggaaccgtta gataactatg agagcttgtc cttgaacgag caaaaacgaa
     6601 aaatcggaga gttgctggaa atggtcgggt tgaatccaga ggacatgcgg aaatacccta
     6661 accaatttag cggaggacag ctccaaagaa ttaatatcgc gcgggcaatt gccttgaaac
     6721 ctaaaatgat tgtattggat gaatcggtaa gtagtttgga catggtgaat caaacccaca
     6781 ttttaggctt gttacgcgaa ttaaagtcgg tattcgggct ttcataccta ttcatcacgc
     6841 acgatataaa agctgcctac tctatttgtg atggactcgc ggtactcgaa aaaggggaat
     6901 tggtcgagat gtgcgacgat aaggatcaaa tttttgcctc ctcccatgcc actgtgagaa
     6961 gtctgatttc atccattctt tccgagcatc cccgacaccg ttctctttct tcagacgaag
     7021 atccatacta attgacttaa accatatatt tgccgcatcg gctaggtaat actttaaaaa
     7081 actttaggca aacatcgctt taaagttttt ttatttgggc ttatttagat ggcctattac
     7141 aaaggtgttc attatgactg catatgttaa atttgcttca caattcccgt tcattgcata
     7201 aaaaaaaaga ccaacatagt acatatcgcc ggtctttgac tcatggtcag ctattaatgg
     7261 ggctctaaca caaagtaata tggtttggag agaagattgt gcaagtgatc gcgtactggc
     7321 tttcatgctg ttcttccgag ccctcttttt gtttctcctc gtgaattctt ccagcgccca
     7381 taatctgctg aaaatgacag cagttatggg cagaaaggaa gcaacaaagg caggctaaaa
     7441 atcaataatg caaagtgaag ctgaaaaata agggaagggt gtcccctcaa gtagaattat
     7501 ctacttttgg gacaccctct tttgtatgat gaaaaaatgt atagttaagc accttaaaaa
     7561 tgggcgcatg atgatggaac aaatacccaa tgtcgcttca taaatctaga gtagctccat
     7621 gaagtggcgg aggtgaagat gaatggatga tttcaaaaaa gagctaaaaa aactaaaggc
     7681 ttccgaaata aaagcggatc aagtacagcg ttgggataaa caaaagatga atgaagcgac
     7741 gcttgttcgc gggcgatgtg gatgtggtag atgtggttgt ggccgctgcg gacgttgtag
     7801 ttgcagttgt tcctgttctt gctcctgctt ctgtagctgt tcctgcttct gcacatgcag
     7861 ctgcacttgc ttcttcccat gctttatcgt atgaatggcg atatcttcta acgataaact
     7921 gaatgaagcg ccctgccagg atgacgtctt ggcaggggtt ttgtttttct gctggcatgt
     7981 gagacaacgt attctacata aaatgacgat gacacatcat gtcgcaaaag ggctgatctc
     8041 gcacaataag ggggaggaga atggttaggc tgaatccttc aatgcgcata aaagtgaagc
     8101 gggatacggt ttatctgcct gattcagatg ggagtgtata ctttcggaac aacatcggaa
     8161 catttcgaat gaagggggag atgattgaac gatgggttga ccagctcatg ccgatgttta
     8221 atggggagta cacgctggcc caattgaccg acgatttgcc ggaagaatac caacaacaaa
     8281 tataccaggt ggcagacacg cttttacaaa atggatttct tcaagacatc agtcgagaga
     8341 agccacatga actatcgcct gaaatcatat cggcctatgc agaacagatt gaatttttgg
     8401 accagtttgg cggatcgggt ggatatttat ttcaaaaata tcgagcggaa aaagtattga
     8461 tagttggggc aggttccttt cttctttctg ttgtccatgc cttgctagaa tcgggctgcg
     8521 ttcaattcca ttacgtcatc gcgaatgaaa ctcccacgaa tcgagagcga ttggacgcaa
     8581 tcatcgagca tgctcgcagg aaagacccgc acgtgaagct ggaggaactg aaaccagcgt
     8641 catgggggat tgcagagtgg tcggaggcta ttgagccttt cgctgctatt ttgtacacct
     8701 cagcgcaggt aaacaaggat gaaatgagcg tcattcattc cgcgtgcaga gagagggaga
     8761 aagtatttgt tcctgccgtt tgtctgatgc aaaaaggaat agctggaccg ttgattcatc
     8821 ccgaatcagc agcttgttta gaatcggctt ggcggcgttt gcaccgacag actttatgtg
     8881 cggatcccga tctacatcca ttttcaatga cggcagcagc gatcctggcg aatattgccg
     8941 tgttcgaatg gtttaaacat gtgactggtg tcaatgaagc tgaggatgaa aacaaggtgt
     9001 atgtactgaa tctggagaca ttggaaggaa gctggcgatc attcctgcct catccgttgg
     9061 tgaataaaga gatgagcctg gaggtattga atagtaagga gcttgaatct cggctatcca
     9121 ataagacgga accaaaggaa ggactacagt ctctgtttca gtcgtggacc tcatcggata
     9181 caggaatttt tcacagctgg gatgagggtg agctcacgca attaccgctc acacagtgta
     9241 tggttacggc cgtcgatcca gtctcggaag gtccggcgga gctgatgccg caagttgtct
     9301 gccctggcta tacccatgaa gaggcacgaa gagaagcggg acttcttggg gcagaaatgt
     9361 acgttggtag aatggtgaag cacctcgtaa ccatagacac tgactttcga gctatgggaa
     9421 atggcaatat gggagtcggc gcaggggaaa cgccagcaga agggcttaat cgtgcactgc
     9481 gacattgctt gacgctcatg tatgtatcag aaatgaaagg gagacaacca acagcgagac
     9541 cagtatacgc tgacacgatt gctgatgaac catgccaatt ttatatccgg tcatttacta
     9601 cgttgggtga aaaaccaacg attgcaaagg gctatgaggt gtacggattt ccggtgtatt
     9661 gggtgggaac gcgcacggga tggtacggga gtattggctt gcaggaacga gacgcattac
     9721 gatcagcgct gatgtatgcc ttgcaacaga ttcagactcc aaccacccaa gtgtccaagt
     9781 atgtcctgac agcgcaatct gttggattgg cgggtgaagc catcgaagtt gcactcaaca
     9841 gcgttcagga agaatcggaa aaagaagtct ggaaacaagc tgccgaggtg ctggcccttc
     9901 atcacctttc tccgctagtc atgaatgccg cggtggagcc tttcctggaa gaagaccttg
     9961 gcggagtatt cgctttgctg ctctcgcagg aggtgcctcg atgagcgctg acattcttat
    10021 cattggagac ggagtactgg cagagctggt ttcggaacgt ttgaggaagg actatcgtgt
    10081 gtggcacagt gaaaacatgg agtctgcgac aagcggagca gatttggctc tcctgttgca
    10141 cgatacgtac cgtcccgctt tgcatttgca ggcagaaaat aactttcgac aagccaacat
    10201 cccatggctg cgcggctttg tttcatttgg ggaggccatc gtaggtccgt tggttcgtcc
    10261 aggtcaaaca gggtgctccc agtgtgcaga tatgcggcga ctgatggcgg gacgtgatcg
    10321 caaagagatg tggaaggtac agcacatgct gagtgaaaaa ggcggcatac tgcgtgaccc
    10381 gtgggcatcc cgctctggat tgttacaggt ggcataccat gtaagcgcgg aggttgatcg
    10441 tatagtagaa ggcaggcaag cccagttatc agagcatatc cagtttattg atttacaaac
    10501 attgacaagc acgcgtcatt tctttttgct gaatccgtta tgtccggtat gcagtcagct
    10561 gcctgaggat tccgaagagc agacgagaat tcgcttgaag cctatcataa agcaaagtcc
    10621 agacagctat cggaccaaat ccatcgccga tttaaaacaa gctctctcca ccgaattttt
    10681 agattcccgt actggatttc taaatgggaa agtacgtgat cttgtctctg tgttcgcaga
    10741 tgtcagtgtc aatcttccgt tattttcaca tgacgagggc acggcaggca ggtctgtttc
    10801 atacgcggat agtgagataa cggcgatttt ggaaggaatg gaaagatatt gcgggttgat
    10861 gccgcgtggc aagaggacga tggtacgcga ctgctatgcc aaccttgcgc cgcatgccct
    10921 tgatccgacg acggtgggaa cccattcaga agagcagtat gccctgcctg attttccgtt
    10981 tcagccgttt gaccccaaac gggaaatgaa ctgggtatgg gggtattctt ttaaagaaga
    11041 gcgacccatt cttgtacccg aactcatggc ctactacagt atgggattcg gggagggagt
    11101 tgtatttgag agctccaatg gctgtgcgtt aggcggcagt ttggaggagg cgatctttta
    11161 cggcatcctc gaagtggtgg agcgagatgc tttcttgttg acctggtatg cccaattgcc
    11221 attgccacgc ctcgatcctg ctacggtcaa tgatcgggaa ttgcttctgt tgatcgatcg
    11281 aatgcagacc gttaccaatt acgatttgta cttgttcgat gcgaccatgg aaaatggaat
    11341 tcctgctgta tggacgattg cgaaaaaccg cggagcggaa ggcttgcacc tcgtttgtgc
    11401 agcaggagcg catccagacc ccatccgcgc tgtaaaaagc tccatttacg aaacggctgc
    11461 tatgctcatg cctttgacag acaaatacga agcgaaccga gacaaatact tgcgcatgct
    11521 tcaagattcg tccttggtga aaaagatgga cgatcatgcg atgctttaca gcttgccgga
    11581 agcatcggag cgcttatcct ttcttatgga tgattcacgt ccaatggtct ctttcgctga
    11641 acaattccct agaagaaacc aaaatcgtga tctaacagac gatttgcggg agttgctcgg
    11701 tgtgttccaa aagctcgatc tcgatgtcat tgtggtggat caaacgacac cagaggtagg
    11761 gcgccacggc ttatcttgcg tgcgcgtatt gattccgggc atgcttccga tgacttttgg
    11821 ccatcatctc acgcgagtaa cgggattgaa aagagtattg gaggtccctg tgaaactggg
    11881 ttacgcgaaa caaccactgc gtgtagatga gttgaatcct tttccgcatc cgtttccata
    11941 acatgcatct gggagtgagc cggatgagtc tcgaaaattt cttgtaccgc cttcattttg
    12001 atacagaaaa tgccaggtca agcgatctcg aagtggattg gggggatgcg ccactgacat
    12061 acaaagtgta cagggggcta cctgtcattc cattaccaga agatgttcct ctttcacttg
    12121 tagatcaaac agtttcacaa gagatgtctc tttctcaatt gggtgcttgg ctatggtata
    12181 gctacggact gatccaaatc agccaatcgt tattaaccac gacctcggca gatgcagaat
    12241 ctgagtcgtt tttgccactt gtaacgaatc gaagaccggt tccgtctggt ggaggactct
    12301 acccgagtga gctgtacgtg tatttgaagc tgtcgagtat tcctccaggt ctataccact
    12361 acgatgtggc ccatcacaga ctcgtacaat tacgcgaagg gaattttgat cacgtcctta
    12421 gccgagcact gggtggcagt tgtccggtac atgcatgctt tggagttgcg ttcgtatcca
    12481 tctatttttg gaagaacttt tttaagtacg atgagttttc ctatcggttg cagggcctcg
    12541 atgctggtgt actgctggga caattgcagg aaatggcaaa ccagttcggt gtgacgaccg
    12601 cggtacatta ccagtacctc gataaagcga taaataaact gctaggattg tctgccgatc
    12661 aagagagtgt atacgcggta gttcccttat cgcttcaaga agaaggggag aggcattcgc
    12721 actcaccggc actatggaca gagcgaggag acgagacggc aagcgaggta atcagagaac
    12781 tgcctgagca aaagcatatg catgttatac gctcaaaaag aatgagacaa tatcctgcgc
    12841 tcttgcaaat gaatgaagct gccatgcagg aatctaccca tgcatttaga cgatattcgg
    12901 atcagttgga aagcaagtgg tctcgtcgtt ttgatgagcg aatccttctc ccgcgtttgc
    12961 agaaaccaag ctatgatctg gcgcaatatt gccgggagcg tttttcacca gaaatggact
    13021 ttatcaggaa gaaaacagac cagaatcagg tagcgcgtat catggaaatg acgatgagtg
    13081 ctttatcgta tggcaatgat ttgggaaata atcaagaagc agcgtgggga aggctttctc
    13141 tttttgtaag cattcatcag gtagaaggga tacaagatgg ggcatacgct tacaaaccac
    13201 tggagcacgc tctttatccg attgtttatg gagatttacg agcacgcctt caagacggaa
    13261 tgaccctgga caacgtgaat ttgtatcaag ggccgctctg ctttcatgtg gcgggtaaac
    13321 gcgatcattt gatcaatcag ctagggttta gaggatatcg cattcagcag atggaggcgg
    13381 gaatcgtcgt gcatcgcttg cttttggcag cgttcacgtg tggaatgggc ggtcacccgc
    13441 tactcggatt tgacgtggag aattgcgatg atctttacaa cctagagacc gaagagaaaa
    13501 cctgcttgat tcaaattccg gtcgggcact atcgcccccg cgccagattt cagaccgggc
    13561 ttcatggata aaaacgtgga agacccgagt cgcgttgacc cgggtcttgt attatgctcg
    13621 tataacggct ttgatacctt gaacgaaacg gtcaatttcc tcgtgggtat tgtacggtgc
    13681 cagccccgct cgtatccagc cgccactttc attgattccc aaacaattgg cgagtgttgt
    13741 cgcatagaag tccccatccg caacgaatat gctatgctcc tcacacaatc gctcacatat
    13801 ttcttgggga gaaaaccctt cgatccgaaa agcgatcgtc ggtgttttcg gtgcatcttc
    13861 atccgcttga tagagtgtga cacccttcat tgcatctagg tcttttcgca gcttttctgc
    13921 cagctgattt tcataagctt cgatcacctc gtaaccagag cggatttttt cagcgaagct
    13981 ttcaccgaga ccaagcgacg caataaattc gatagcgggt ctgattcctg cgatcccttc
    14041 atgattttgt gttccggtct ccagtttatc tggataagaa gagggggcag gaaccaattt
    14101 gtaaacatcg agtgcttcaa aaatttcttt acggatgaca gcgattccca catgtggacc
    14161 aaaaaacttg taagcggaac agagcaggat atcggctcca atctcgtcac gatggataga
    14221 gaagtgaggg accgcatgca cggcgtcgac agcaacaacg actccttttg tgcgtgcttt
    14281 ttgggaaatg gcagcgagat catggatcgt tccgacagca ttggaagcaa gcccgactgc
    14341 caaaagtctg gttctggaag taaggagggt atcgagctca tctagttgta acgtaagtgt
    14401 ctctttattc acctttaacc accgaacggt cattccgcga tcagcggcaa cagtcagcca
    14461 cgggtctaca ttggcgcggt gatccatctc ggagacgatg atctcatccc cttctttcca
    14521 atgtcgacct aatgcacgcg caatcgcaaa ggtcagggtg gtcatattcg caccgaaggc
    14581 tacctctagc ggcctcacat ggaagaggtc ggctacggct tgcttggcat ctgccaggat
    14641 ggcttctgtc tccttgctcg ttggaaagga gccgtgtaaa ttcgctccac cgttcgccat
    14701 atagcgatag atcgcgtcca tggaggattt tacgacttgc gagccgcctg ggccatccag
    14761 ataaacaact ggcttgcctt tgtacgttcg ttgtagggcg gggaattgct cacggacttt
    14821 ttcaatgggg aaatgtcctg acgcaacttc taatcgccaa tcattggagc gcataaaact
    14881 tccaggaggg tattcaaaga cgcattctga ttgcagagtg aaaccgagct tacggcaaat
    14941 ggcattcgag gcagggttgt ccacggaggg ataggcatga atatacttgt gtcttcgttc
    15001 ttggttgatg cgtgtgatga gtgaggctaa agccatagag gcgattcctt tcccttgaaa
    15061 ggggggcagg acgctccagc ctacttcgta tatgttttct ccttgccaga tgcggtccca
    15121 atagccgatg cttccgacag gggtgtgatc tggcagcagt acgatgctga acatcttgct
    15181 cgtaagctgt ccgtccttat tgacgtatcg ttcgtgccga gcaaggagct gctcctccgt
    15241 ctccggacct ccaagatgct ccatcatggc tgacccattc aaaagacgca gcaaggaaag
    15301 atcgtgatcc gcccagggct gaatgcggac aagcgcagtg tttagcgttg tggacatttt
    15361 ttcactcctt atcaactgga tttccgggtg tccatcctca ttcgttatct ctcattattc
    15421 ggaaaagata cccattaatc aatcttccat tcgttctgag aaagagggat ggaaaatcat
    15481 gctataatag tgatgcccga gtgattctta ttatcggagt atggaaagag tagctgaggt
    15541 ggaggaatag accctttctg aaaaggcata tgtcgagtaa atccaacgta aatattttca
    15601 ccgacaataa aggaaagagg aaggggtacc tgtccatgaa tgaaaaaagc attcaaacac
    15661 aacggctcat attgattcca tttacacata gaatagcgac gaatattttg caagaaaatt
    15721 acgaggagtt attggatttg gggcttacat taggcaaagg ctggcctgat gaggatgcga
    15781 tggaaacgat ccccaaaatc atcaaagcac tcgaactcac aggggaaccg acaggatttg
    15841 aatcgtggat gatcattaca caggatggca tgaagatcat cggggatgta gggttcaaag
    15901 gtgtcccgaa tgcgcaggga gaagtggaca tcggctatgg aattattgaa gccgagcgaa
    15961 aaaaaggcta cgcgtacgag gcggcaaaaa gcttagcgaa ttgggcgttg ttgcagccac
    16021 atgtgaaaaa aattacggcg aagtgcttgc tagataacat agattcggca aaattattag
    16081 tcaaaatggg ctttaccgaa ataaagaggg acgacacaat aatttactgg tctaggcaga
    16141 aggaatagca cggaagaaca gatgcagagt ttcacacgaa aaaaaggacg cacacatggg
    16201 cagtcctttt ttcatggaga acatcagttg ctggaatttt ctatgggaat gttgtagata
    16261 tgtttcgtgc catctttata cgttacttcg agtacacctg attgaaggga cggacctttt
    16321 gcttttactt ttttcttcgt ggaaaactct cctgacttcg aatcgattcg caacgtaatg
    16381 atcgtattga agacctgaat cgttacgctt ttgatatctt tattagaggc tttccctgtc
    16441 actttgagtt cgtaatacga tttagggagc ttgctcgatt cagactggat ttcaatctca
    16501 tctggattga gagccagccc tggaagaagt ttcgtctgca tctttacgaa ttcctcttta
    16561 cgttcatctt cgggtccaac gaggatgtgt acggaagaat tcaattgaaa atagtctggc
    16621 gtaagatcat ccggcagttc atctgtgcgg aaatattcat cttgctcgat agttctcccg
    16681 ggctttaagg ttttttcctg gatgaccggg ggacatacag gttcgttttc agggtaagga
    16741 agctcccaag agtctccaga ggcatacgct tctagtcgtg ttgttacacc gtagcaatga
    16801 ccagtcgtgt atgtgattgg tttccgcgaa atattggtga caatcgtatt tacgtggtac
    16861 gttggtgagt cgtattttgg attgtcgatt tcggtaacgg tcacttgaaa ccgaagtcct
    16921 tctttcttca atggtttgtc aatgaaaaac atgccggttg cttttgcttc ggccgcgttt
    16981 acattcacgg cgccagccgt cataaccagt aaaagacata cgagtgaatg gacaatcttg
    17041 cgaaacacac agttcacctc ctcacgattc gtttttgagt aatgtgcatg gaggcacctt
    17101 ttaaatattc catatattac ctccctttgc aatgtttttt gctcaggaat attttaaatg
    17161 aaaattttca aaggaaaggt aacccaagac ttccttcttt cgtattgaaa taaaggaaaa
    17221 gatgatcgct tttcattgaa ctatgcaacg cgtgtctcta tactggagag ataagcattg
    17281 gtaaataatt gtgagggata gtatgcagaa ctggatgacc caaattattg aacaatatag
    17341 ttacttcggt atcttactga tgatggcact ggaaaacatc tttccaccca taccttctga
    17401 ggtgatcttg acattcggtg gatttatgac gacgcaatca tccttaacgg tttttggcgt
    17461 aatcttgtca gctacaatcg gttcggtaat cggggcaatc attctctacg gaatcggtta
    17521 ttacctagac gtcaaaaaaa tagagaagat cgtagcgaga tgggggcata ttctgcggat
    17581 taaaccggca gatatccata aagcgaatga atggttcgac cgatacgggt actggacgat
    17641 ctttttttgc cgtatggtcc cattaatcag aagcctgatt tccattcctg caggtatgac
    17701 caaaatgaat ttcccgctgt ttttgttgtt tacaacactt ggtacgttta tttggaacat
    17761 cgtcctcgtg atggctggtc acttattggg ggaatcgtgg gaagatattc tgtactactt
    17821 cgatctctat tccaatgtcg tttatgctgt actcgcattt gcggggatag cgttcctcat
    17881 ttttttcctt cgcaaacgaa aagcggatgc ctaaaacctt caaaccatct ttcctacaag
    17941 ggaaggtggt ttttccattt ggaaccaaga ggtaaacata ttgcaaaaag tcgtaaattt
    18001 cttgcaaata caagatgtca aaattgagct aaggtgtagg gaggggaagt agtgtcatgg
    18061 gcaccgccct tattctttag gctgggggag atgcaacttg atcgatttgt tactcgtaaa
    18121 cggcgtagtt attaccatag acaaagaccg tcgggttgca cgcatcattg tatattgcca
    18181 ggcttcgttg acgcacatgg tcatggcgga cattcgttgt tcaaaacgat tgcgacggat
    18241 aatatcaacg actggatgtc aatcatgacc aacacttata agcactacgt gacagacgat
    18301 ttctggtact acgagggaaa gctgtcagca ctggagcggc ttaaagctgg gattacgaca
    18361 ggtgttagcg tcctgggctc gatgccgcgc tcagatgatc cgatctttgc cttgaatcac
    18421 gccaaagcgt acaacgaggt tggcgttcgt gaaatcgtag cgacaggtcc atgcaaccca
    18481 ccgtggccgc atcccttcag ccgctgggtc gatggacaaa aagtaacgaa ggaagtcagc
    18541 tatgagcagg ttctcgctgg agcagaagca gtgatcgaag ccctgaatca cgcgaataac
    18601 gataaaacca gagcatacat aactccattt gtcatcgtga cctctgtcaa tccgtcctac
    18661 ccgacaccag ctgaccaatt gtttggctta acggatttcg accgttacca agcccggaaa
    18721 atcagggaga ttgcgaaaaa gtacgacacg cgcatccatt ccgatgcttt tggaggcatg
    18781 attcacctcg ccattcaaga caaagagtac gcgctgctcg gtccagacgt acacttgcag
    18841 cattgtcggg gaatctcttt tgacgaggcg aaaattttgg ccgaaacagg aacgaatgtt
    18901 agtgcttctc ctggttttgg tcaaatcaac gcacgcaccc cgattacaga attgctggag
    18961 atgggagcga ctgttgcgat cacgacagac ggcacctcgc caatgactcc ttttgatatg
    19021 ttccaggcca tgcgcagaat gcagctgttg caacaagcgg cgctgcgtga ctattattac
    19081 ctcccgccgg gtaagctgct ggaaatggtc acgattgatg cggcacgctg tgtcggttgg
    19141 gatgacgagt tggggtcgat tgaggctggt aaaaaagcag acgtcattac tgtaaatatg
    19201 catcaggccc acttgaatcc cgagaacatg catgtccatc gtgtcgtcta tcaggcagtc
    19261 ggcggagatg tgaaccatgt cattgtcgat ggtgagctga ttatggacga gcgccgtgta
    19321 ttgactgtgg atgaaaagca aatcctcaaa caagcgaatg aagaggcgaa tcgcacgatc
    19381 gcgcgggcag gtctggaagt ctacatgcag ccaagcaagt atttctgggg acatgcgcga
    19441 gcttatttgg atgagagacg atttgatccg acgaagttgt aggggaaaaa agagtagtta
    19501 aagaagacga cgtgtaatgc tgcacataaa ctttggatac cgcattaaat aggagaaggt
    19561 gaccaccgcc ttcccttttt tattggatta tagttgacaa aaacgatagg attaatcatt
    19621 atttattcat aatacccatc gacaaagttg gaataaaaag aggtgcagcc atgtatctga
    19681 ctattgataa tgttacgaaa catttcgtaa atgaagagaa acaaaaagta aaggtgctcg
    19741 atgatatcaa tcttgaagtg gaaaagggca gcttcgtttc cattgtcgga ccctctggct
    19801 gtggaaaatc gacgctgctc tacttaatag ccggtttgga tcaacctgac agcggtgaca
    19861 tacacgttgc tggcaacaaa gtgaataagc ccggtcccga cagagttgtc gtttttcaag
    19921 aagcagggtt atttccatgg ctgaccgttt tggaaaatgt tacatacggg ctcaagttga
    19981 agaaaatgtc tacagcgaaa gccaacgaaa aggcgctgga agtgctcaaa atggtccatt
    20041 taagcaagta tgttcattcc tatccccatc agctctcagg cgggatgaag caacgtgtag
    20101 ccatagctcg ggcgcttgtc atggaacccg acattttgct gatggatgaa ccgttctcgg
    20161 cgctggatga acagacgcgg atggttcttc ataaggagtt gcttgagatt tggcggacga
    20221 ccaaggtcac gatttttttc gtcacccata atatccggga ggccgttcag cttgcggaga
    20281 ggatcgtcgt ttttgccaca cgccccggaa aaatcaagga gatcattgcg gttcctgcta
    20341 tgcgcgatgg agtcatgccg gacagtgtga cagtaaacac ggagcagaag gtgctgtcga
    20401 tcctgcaaga agagatagaa aaggtgctga aggaggaaat gggcaatgac tacagcttta
    20461 agacgggtca tcttcatcgc tatgatagcg gcgatatggg aagtcacatc taaattatcc
    20521 ggactgccat cgttcatgtt tccaagtttg acccaggttt tcgaaacact cgtaaatggc
    20581 ttgataagcg ggcaaattac cgctgcgatt ggaaaaagta tgggacgaat cctgttgggc
    20641 tttctcattg ccattatcgt cggactgata ttgggttact tcatttggag atacaaactc
    20701 gtagaagata cgcttggttt tgtcgtgact gcgcttcaat ctatcccgag cattgtctgg
    20761 ttcccgctcg ccattatctg gtttggctta aatgacttct ccattctgtt tatcgtgacg
    20821 atcggggcga cctggaccat gacggtaaac gcgaccagcg gtttcaaaaa tgtcccgccg
    20881 ctatatcagc gggtagcaag gacttacggt tcgactggct ttcactttgt acgaacggtg
    20941 attctccctg catccgtacc gcaaatcatt tctgggcttc gaattgcttg ggcattttcc
    21001 tggcgggcac tcatggctgg tgagttgctc gggggtggcg gtggtctcgg tcaattgctc
    21061 gagatgggac gttcacttgg acaaatggat ttggtgatat ctgtcatgat cattattgcg
    21121 atcatcggta ccatcgtcga taatgttgtc ttttcgcgga tcgaacgcaa cgttcagatg
    21181 aagtggggag tccattcata aaaagaaaaa tggctaagga gtgtgtcgtc acatgtttaa
    21241 aaaagtgttc agtaccgttg tcgcctccct attattgatg gggattgcga gcgggtgctc
    21301 tacaggcgga gcagaatcct ctgagaagga agtaaggatc ggatatttcc caaatctgac
    21361 ccatagcgca acgatcattg cactggaaaa aggctatttt aaggaagcct tcggtgctga
    21421 tatgaagatt caaactaaaa cggtcaccaa tggcggattg tttatggaag caatggctac
    21481 taaagcaatt gatgtaggga cagtcggacc aggaccgctg ttgaactttt atgtcaagca
    21541 tcccgggtat cgtttgattt caggtgcggt caatggcgga gcagtcctcg tcatgaatgg
    21601 ttcaaccaat attacggaac taaaagattt aaaaggcaag aaaatcgcga ttccggtaat
    21661 cggcagtaca caggatgtca tgctcagaaa agcactgaat gaagttggac tgaaaccgac
    21721 gacgaatggt ggagatgtgg aactgtatgc ggcagctccg gcagatacgg cagcattatt
    21781 cgtacaaaaa tccgttgacg gtgcagcaac gcaggagccg tggggatatg tactggaaaa
    21841 tcaggcgggg ggaaaattgc ttttggactg ggatcaattc gcttggggga aagaatcaac
    21901 caataccgtg gtagcagcca gcgatgaatt tttgaaacga gaaggattgg caaccgccta
    21961 cctgcaagca cataaaaagg cagtcaaatt cattcaggaa aatcccgaag aaagccaaga
    22021 cctgatcatc aagcatttga aaaatctgac tggcaaagag ctgagcaaaa aagaagtgca
    22081 ggcagctttt tcccgtttgg aagtaacaac ggcggtcaat gaaaaagtta ttcaggaaat
    22141 ggcagatatc agccaggagg ccggctatat ttccagtaat aaaattgatg gcttgattga
    22201 tttgaaatac ttagaagcag cgaaataata tcggctgaga aggaggagat tcagcaggag
    22261 gaacgagggg tggaaaggaa ttagatggga aaggaggtca tgccgcgatg agaccaaatg
    22321 aacaaggaag taatcaaccg aacgacacct cattggagac acagattcat actgatttcc
    22381 aacaagaaat gacgtacggc gattatttac agctcgatca aatcttgtcg agtcaacagc
    22441 gtcaatccac ccatcatgat gaaatgctgt ttattatcat tcatcaggtg agtgagctat
    22501 ggatgaaaca aattttgcac gaactgtcag cagcaaatga gtgcatctgc aatcacgatc
    22561 tggagcctgc tttcaaaatg ttcgcgcgag tctcgcgtat ccagcagcaa ttgattaaat
    22621 cgtgggatgt cctttctaca ttgacgccag ctgattacct ccagttccgt gacaagctgg
    22681 gtcattcgtc cggttttcaa tcctatcaaa accgactcat cgaatttacg ctaggatata
    22741 agaaccagca tgtcctagcg gtgtatgcgc atcaaccaga gcttcacgcc aaaatgagcg
    22801 cagccttgca gcagcccagc atttacgatg cggcgatcag ggagatggct gctcgtggct
    22861 tgccgattga tccggaatgt ttgaatcgcg actggtcaca gccgtatcaa ccaaatcaga
    22921 gtgtagagca agcctggctg accgtgtatc gaaatgtgaa ccagtattgg gatttgtacg
    22981 agttggcaga aaagctggtg gacatcgcca gtcagcaaca acaatggcgt tttaaccata
    23041 tgacaacagt cgagcgcatc ataggccaaa agccgggaac aggagggtcc tcaggcgtca
    23101 tgtacttacg cagagcgctc gatcaccgct ttttcccgga gctttggagc ttgcggacgt
    23161 tgttgtaaaa aactcttcaa aaaaagcgag aaaagcgtct tggggaccca gggcgctttt
    23221 tcgcttgtag tactcctttc acattttttc acatatctta cctaatgttg ggtataaata
    23281 cccttctttt cctgacaaac atatgttttc attttttata gtatacctat tttttcaaga
    23341 acaaccagaa atggagtggg catttggatg gaaacaatga agccacctat ggaagtgtta
    23401 tatgcgaaac agctgaatgc gctgcgatcc catgatacag ggacaaaacc tcccaattgg
    23461 ctgatgtcgc cgagagcagt gcgcgatttt attttaggaa cggatgaacc cctctcttat
    23521 gagggcgaag gtatatcgat tacgaagaag ttctatggag acgaagtgct a
//
