LOCUS NZ_CP018145 23571 bp DNA circular CON 05-MAR-2024 DEFINITION Brevibacillus formosus strain NF2 chromosome, complete genome. ACCESSION NZ_CP018145 VERSION NZ_CP018145.1 KEYWORDS RefSeq. SOURCE Brevibacillus formosus ORGANISM Brevibacillus formosus Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus. REFERENCE 1 (bases 1 to 6437015) AUTHORS Fu,B. and Li,Z. TITLE Direct Submission JOURNAL Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: HGAP v. 3 Genome Coverage :: 167.68 Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 03/05/2024 02:46:36 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.6 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,168 CDSs (total) :: 5,986 Genes (coding) :: 5,821 CDSs (with protein) :: 5,821 Genes (RNA) :: 182 rRNAs :: 16, 17, 17 (5S, 16S, 23S) complete rRNAs :: 16, 17, 17 (5S, 16S, 23S) tRNAs :: 127 ncRNAs :: 5 Pseudo Genes (total) :: 165 CDSs (without protein) :: 165 Pseudo Genes (ambiguous residues) :: 0 of 165 Pseudo Genes (frameshifted) :: 85 of 165 Pseudo Genes (incomplete) :: 95 of 165 Pseudo Genes (internal stop) :: 22 of 165 Pseudo Genes (multiple problems) :: 35 of 165 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 14:35:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 1773547 Orig. end :: 1797118 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to CP018145.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ This genome has a base modification file available. COMPLETENESS: full length. FEATURES Location/Qualifiers region 1..23571 /candidate_cluster_numbers="1" /contig_edge="False" /product="azole-containing-RiPP" /region_number="4" /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)" /tool="antismash" cand_cluster 1..23571 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)" /kind="single" /product="azole-containing-RiPP" /protoclusters="1" /tool="antismash" protocluster 1..23571 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[10000:13571](+)" /cutoff="10000" /detection_rule="((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)" /neighbourhood="10000" /product="azole-containing-RiPP" /protocluster_number="1" /tool="antismash" proto_core 10001..13571 /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)" /neighbourhood="10000" /product="azole-containing-RiPP" /protocluster_number="1" misc_feature 67..76 /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: strong, score: 18.31" /tool="antismash" misc_feature complement(342..355) /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: medium, score: 21.32" /tool="antismash" misc_feature complement(598..611) /note="TFBS match to PerR, Peroxide regulator, confidence: weak, score: 23.22" /tool="antismash" misc_feature complement(599..614) /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 22.69" /tool="antismash" gene 754..975 /locus_tag="BP422_RS08895" /old_locus_tag="BP422_08655" CDS 754..975 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS08895" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="BP422_08655" /product="hypothetical protein" /protein_id="WP_088907417.1" /transl_table=11 /translation="MIQDLSEIFSSQPLIKKILRKKWKRTFMVRASFLQNDPNMPVKLV DELFGEKVKTALGKLPGTVIVDAGYGGI" gene 1015..1719 /locus_tag="BP422_RS08900" /old_locus_tag="BP422_08660" CDS 1015..1719 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019419822.1" /locus_tag="BP422_RS08900" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08660" /product="alpha/beta hydrolase" /protein_id="WP_088907418.1" /transl_table=11 /translation="MIRQNLEIGNIPAILWGDKSDKLFIVVHGNMSNKADDSIIVFAEE ATAVGYQVLSFDLPQHGERKDDTYLCKVQNCVRDLNKIMTYAKSLSNHISIFACSMGVY FSLLEYCHEPLNQCLFLSPVVNMERIIDNMMTWFNVSESRLKIEKEISTPIGQTLYWDY YCYVKEHPIVAWNNPTSILYGSGDNLCEFDIVSEFAKRFNCNLQVMENGEHYFHTQEQL QYFRQWLKKHIY" misc_feature complement(1842..1857) /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 21.95" /tool="antismash" misc_feature 1845..1860 /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: strong, score: 26.61" /tool="antismash" misc_feature 1847..1861 /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: medium, score: 21.0" /tool="antismash" misc_feature 1848..1861 /note="TFBS match to PerR, Peroxide regulator, confidence: weak, score: 22.06" /tool="antismash" misc_feature 1886..1904 /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: weak, score: 22.83" /tool="antismash" gene 1888..3513 /gene="nikA" /locus_tag="BP422_RS08905" /old_locus_tag="BP422_08665" CDS 1888..3513 /EC_number="7.2.2.-" /GO_component="GO:0009897 - external side of plasma membrane [Evidence IEA]" /GO_component="GO:0030288 - outer membrane-bounded periplasmic space [Evidence IEA]" /GO_component="GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]" /GO_function="GO:0015413 - ABC-type nickel transporter activity [Evidence IEA]" /GO_function="GO:0016151 - nickel cation binding [Evidence IEA]" /GO_process="GO:0015675 - nickel cation transport [Evidence IEA]" /codon_start=1 /gene="nikA" /gene_functions="transport (smcogs) SMCOG1068: extracellular solute-binding protein family 5" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_013919971.1" /locus_tag="BP422_RS08905" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08665" /product="nickel ABC transporter substrate-binding protein" /protein_id="WP_088907419.1" /transl_table=11 /translation="MFGSTKKAVLLMVAVILLLSTTLLGCTKQETESNGENKAASAEKV ITLSWPRDIGPMNPHTYNPSQLFAQSMIYEPLVSYKEGGKLEPYLAESWSISKDGKEYT FKLRQNVKFSDGTPFNAAIVKKNFDAVMKNPKLHSWLGVINALDKTEVVDEQTFKMTLK EPYYPTLQDLALVRPVRFLGEAGFPDDGDTSKGLKKPIGTGPWMLADYKKDEYAVFTRN PNYWGESPKIDKVTVKIIPDAETRVMAFEKGELDLIYGEGVISMDSFNQLKESGKYVTE LSDPVGTRSLLLNTSNEKLADLRVRMALQHGFNKQAMVEGITLGLEEKADNILSKNFPY TNMDVQQVEYNVEKANAYLDEAGWKLPAGKTVREKDGQPLELELIYDKTDPIQKAMAET MQAEWGAIGVKLNITGLELTVQIKRRKAGEFDLDFWYNYGAPYDPHSFINVVAEKGWGV SEAHSRLSMKQELDQQIKDTLASTDEAKREQLYDSILRTLQEQSAIVPVSYIKKTVVYQ KNVKDFSFPANRDEHPFYGIGISK" gene 3532..4477 /gene="nikB" /locus_tag="BP422_RS08910" /old_locus_tag="BP422_08670" /pseudo="" CDS 3532..4477 /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_component="GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]" /GO_function="GO:0015413 - ABC-type nickel transporter activity [Evidence IEA]" /GO_process="GO:0015675 - nickel cation transport [Evidence IEA]" /codon_start=1 /gene="nikB" /gene_functions="transport (smcogs) SMCOG1118: binding-protein-dependent transport systems" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_013373739.1" /locus_tag="BP422_RS08910" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08670" /product="nickel ABC transporter permease subunit NikB" /pseudo="" /transl_table=11 /translation="MVSYIGKRALAIIPIVLFAILITFVLIHISPVDPAEAYLTAAHIH PTEELLAEKRHEFGLDQPLIVQYFQTVMKICRLDFGRSYITNEPVWDEVTARMPATIQL AVSSILFAMIVSIPLGFFVSGL" gene 4474..5307 /gene="nikC" /locus_tag="BP422_RS08915" /old_locus_tag="BP422_08675" CDS 4474..5307 /EC_number="7.2.2.11" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_component="GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]" /GO_function="GO:0015413 - ABC-type nickel transporter activity [Evidence IEA]" /GO_process="GO:0015675 - nickel cation transport [Evidence IEA]" /codon_start=1 /gene="nikC" /gene_functions="transport (smcogs) SMCOG1085: binding-protein-dependent transport systems" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003183802.1" /locus_tag="BP422_RS08915" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08675" /product="nickel ABC transporter permease subunit NikC" /protein_id="WP_088907420.1" /transl_table=11 /translation="MIPHIRTVLKGQKTITVCSVILLVFAIITVLAPWISPHDPIKVNV AMKLKPPCTEHLLGTDHLGRDNLSRLLHGARISLGFAFLIFVSSIGIGLIVGTIAGYKG GWIDTVLMRFCEGVMAFPNLVLVLGIVGVFGPGLIQVVLALMLVQWVYYARMFRSMVVS LKERNFIIAARISGSSQWKIIKQHMIPNILPPILVMGTLEMGWAIMDISALSFLGLGIQ PPTPEWGAMIHEGKGFIRSHPELMLYPGLMILFVVITFNVLGEALSERFGVKRRF" gene 5326..6150 /gene="nikD" /locus_tag="BP422_RS08920" /old_locus_tag="BP422_08680" CDS 5326..6150 /EC_number="7.2.2.-" /GO_component="GO:0009898 - cytoplasmic side of plasma membrane [Evidence IEA]" /GO_component="GO:0043190 - ATP-binding cassette (ABC) transporter complex [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0015413 - ABC-type nickel transporter activity [Evidence IEA]" /GO_process="GO:0015675 - nickel cation transport [Evidence IEA]" /codon_start=1 /gene="nikD" /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017691684.1" /locus_tag="BP422_RS08920" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08680" /product="nickel import ATP-binding protein NikD" /protein_id="WP_088907421.1" /transl_table=11 /translation="MEEPRKVLQVSGLHVKVKAEQGMLSLIQDIHFDLKRGQVLGLVGE SGSGKTVTCNSLLQLLDQKNTIVEGSIQLNGRELNGLKAEEMRRIRGKEIAFIMQNPMS AFTPVYTIGMQFIETIRTHTMLTKKQAIELAVTSMEDVNLPDPPKLMNLYPFQLSGGML QRVMIAISICLRPSVVIADEPTTALDVVNQLQVLRQLDRLRLEYGTSIMLISHDLGVIS ELADEVAVMQHGRIVEQANVFKLFDHPQHAYTKKLLNARPAFPLHQLNRESV" gene 6213..7031 /gene="nikE" /locus_tag="BP422_RS08925" /old_locus_tag="BP422_08685" CDS 6213..7031 /EC_number="7.2.2.11" /GO_component="GO:0009898 - cytoplasmic side of plasma membrane [Evidence IEA]" /GO_component="GO:0043190 - ATP-binding cassette (ABC) transporter complex [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0015413 - ABC-type nickel transporter activity [Evidence IEA]" /GO_process="GO:0015675 - nickel cation transport [Evidence IEA]" /codon_start=1 /gene="nikE" /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007433071.1" /locus_tag="BP422_RS08925" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08685" /product="nickel import ATP-binding protein NikE" /protein_id="WP_088907422.1" /transl_table=11 /translation="MLLQVKDVTHSYGVPRLFWRSDRRVPVLSDISLTIEQGMCLGLLG TSGAGKSTLGKVILGLEKPRQGQVFFQGHDLYRTDIQTRKALRRDLQVVFQDCYSSVNP RMTAERIIGEPLDNYESLSLNEQKRKIGELLEMVGLNPEDMRKYPNQFSGGQLQRINIA RAIALKPKMIVLDESVSSLDMVNQTHILGLLRELKSVFGLSYLFITHDIKAAYSICDGL AVLEKGELVEMCDDKDQIFASSHATVRSLISSILSEHPRHRSLSSDEDPY" gene 7731..7922 /locus_tag="BP422_RS08935" CDS 7731..7922 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="BP422_RS08935" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_236841331.1" /transl_table=11 /translation="MKRRLFAGDVDVVDVVVAAADVVVAVVPVLAPASVAVPASAHAAA LASSHALSYEWRYLLTIN" aSDomain 8061..8357 /aSDomain="Heterocycloanthracin_C_RRE" /aSTool="RREfinder" /database="RREFam.hmm" /description="RRE-containing C protein in a heterocycloanthracin LAP cluster" /detection="hmmscan" /domain_id="rrefinder_BP422_RS08940_Heterocycloanthracin_C_ RRE.1" /evalue="1.00E-42" /identifier="RREFam011.1" /label="BP422_RS08940" /locus_tag="BP422_RS08940" /protein_end="99" /protein_start="0" /score="135.0" /tool="antismash" /translation="MVRLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERW VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQDISREKPHELS" gene 8061..10004 /locus_tag="BP422_RS08940" /old_locus_tag="BP422_08700" CDS 8061..10004 /GO_component="GO:0005575 - cellular_component [Evidence IEA]" /GO_function="GO:0003674 - molecular_function [Evidence IEA]" /GO_process="GO:0030152 - bacteriocin biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) TIGR03693" /gene_functions="biosynthetic-additional (rule-based-clusters) Heterocycloanthracin_C_RRE" /gene_functions="biosynthetic-additional (rule-based-clusters) Thiopeptide_F_RRE" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007717950.1" /locus_tag="BP422_RS08940" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08700" /product="putative thiazole-containing bacteriocin maturation protein" /protein_id="WP_088907425.1" /sec_met_domain="TIGR03693 (E-value: 3.2e-182, bitscore: 605.5, seeds: 2, tool: rule-based-clusters)" /sec_met_domain="Heterocycloanthracin_C_RRE (E-value: 2.1e-40, bitscore: 135.0, seeds: 5, tool: rule-based-clusters)" /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.4e-12, bitscore: 45.1, seeds: 20, tool: rule-based-clusters)" /transl_table=11 /translation="MVRLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERW VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQDISREKPHELSPEIIS AYAEQIEFLDQFGGSGGYLFQKYRAEKVLIVGAGSFLLSVVHALLESGCVQFHYVIANE TPTNRERLDAIIEHARRKDPHVKLEELKPASWGIAEWSEAIEPFAAILYTSAQVNKDEM SVIHSACREREKVFVPAVCLMQKGIAGPLIHPESAACLESAWRRLHRQTLCADPDLHPF SMTAAAILANIAVFEWFKHVTGVNEAEDENKVYVLNLETLEGSWRSFLPHPLVNKEMSL EVLNSKELESRLSNKTEPKEGLQSLFQSWTSSDTGIFHSWDEGELTQLPLTQCMVTAVD PVSEGPAELMPQVVCPGYTHEEARREAGLLGAEMYVGRMVKHLVTIDTDFRAMGNGNMG VGAGETPAEGLNRALRHCLTLMYVSEMKGRQPTARPVYADTIADEPCQFYIRSFTTLGE KPTIAKGYEVYGFPVYWVGTRTGWYGSIGLQERDALRSALMYALQQIQTPTTQVSKYVL TAQSVGLAGEAIEVALNSVQEESEKEVWKQAAEVLALHHLSPLVMNAAVEPFLEEDLGG VFALLLSQEVPR" aSDomain 8082..8324 /aSDomain="Thiopeptide_F_RRE" /aSTool="RREfinder" /database="RREFam.hmm" /description="RRE-containing F protein in a thiopeptide cluster" /detection="hmmscan" /domain_id="rrefinder_BP422_RS08940_Thiopeptide_F_RRE.1" /evalue="1.10E-14" /identifier="RREFam004.1" /label="BP422_RS08940" /locus_tag="BP422_RS08940" /protein_end="88" /protein_start="7" /score="45.1" /tool="antismash" /translation="MRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGEMIERWVDQLMPM FNGEYTLAQLTDDLPEEYQQQIYQVADTLLQNGFLQ" gene 10001..11941 /locus_tag="BP422_RS08945" /old_locus_tag="BP422_08705" CDS 10001..11941 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) azole-containing-RiPP: TIGR03604" /gene_functions="biosynthetic (rule-based-clusters) azole-containing-RiPP: TIGR03882" /gene_functions="biosynthetic (rule-based-clusters) azole-containing-RiPP: YcaO" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016740499.1" /locus_tag="BP422_RS08945" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08705" /product="TOMM precursor leader peptide-binding protein" /protein_id="WP_088907426.1" /sec_met_domain="TIGR03882 (E-value: 2.3e-47, bitscore: 159.6, seeds: 35, tool: rule-based-clusters)" /sec_met_domain="YcaO (E-value: 1.8e-75, bitscore: 253.2, seeds: 127, tool: rule-based-clusters)" /sec_met_domain="TIGR03604 (E-value: 4.3e-122, bitscore: 406.0, seeds: 25, tool: rule-based-clusters)" /transl_table=11 /translation="MSADILIIGDGVLAELVSERLRKDYRVWHSENMESATSGADLALL LHDTYRPALHLQAENNFRQANIPWLRGFVSFGEAIVGPLVRPGQTGCSQCADMRRLMAG RDRKEMWKVQHMLSEKGGILRDPWASRSGLLQVAYHVSAEVDRIVEGRQAQLSEHIQFI DLQTLTSTRHFFLLNPLCPVCSQLPEDSEEQTRIRLKPIIKQSPDSYRTKSIADLKQAL STEFLDSRTGFLNGKVRDLVSVFADVSVNLPLFSHDEGTAGRSVSYADSEITAILEGME RYCGLMPRGKRTMVRDCYANLAPHALDPTTVGTHSEEQYALPDFPFQPFDPKREMNWVW GYSFKEERPILVPELMAYYSMGFGEGVVFESSNGCALGGSLEEAIFYGILEVVERDAFL LTWYAQLPLPRLDPATVNDRELLLLIDRMQTVTNYDLYLFDATMENGIPAVWTIAKNRG AEGLHLVCAAGAHPDPIRAVKSSIYETAAMLMPLTDKYEANRDKYLRMLQDSSLVKKMD DHAMLYSLPEASERLSFLMDDSRPMVSFAEQFPRRNQNRDLTDDLRELLGVFQKLDLDV IVVDQTTPEVGRHGLSCVRVLIPGMLPMTFGHHLTRVTGLKRVLEVPVKLGYAKQPLRV DELNPFPHPFP" gene 11964..13571 /locus_tag="BP422_RS08950" /old_locus_tag="BP422_08710" CDS 11964..13571 /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) azole-containing-RiPP: PF00881" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248326.1" /locus_tag="BP422_RS08950" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08710" /product="SagB family peptide dehydrogenase" /protein_id="WP_088907427.1" /sec_met_domain="PF00881 (E-value: 2.6e-06, bitscore: 26.0, seeds: 78, tool: rule-based-clusters)" /transl_table=11 /translation="MSLENFLYRLHFDTENARSSDLEVDWGDAPLTYKVYRGLPVIPLP EDVPLSLVDQTVSQEMSLSQLGAWLWYSYGLIQISQSLLTTTSADAESESFLPLVTNRR PVPSGGGLYPSELYVYLKLSSIPPGLYHYDVAHHRLVQLREGNFDHVLSRALGGSCPVH ACFGVAFVSIYFWKNFFKYDEFSYRLQGLDAGVLLGQLQEMANQFGVTTAVHYQYLDKA INKLLGLSADQESVYAVVPLSLQEEGERHSHSPALWTERGDETASEVIRELPEQKHMHV IRSKRMRQYPALLQMNEAAMQESTHAFRRYSDQLESKWSRRFDERILLPRLQKPSYDLA QYCRERFSPEMDFIRKKTDQNQVARIMEMTMSALSYGNDLGNNQEAAWGRLSLFVSIHQ VEGIQDGAYAYKPLEHALYPIVYGDLRARLQDGMTLDNVNLYQGPLCFHVAGKRDHLIN QLGFRGYRIQQMEAGIVVHRLLLAAFTCGMGGHPLLGFDVENCDDLYNLETEEKTCLIQ IPVGHYRPRARFQTGLHG" gene complement(13612..14826) /locus_tag="BP422_RS08955" /old_locus_tag="BP422_08715" CDS complement(13612..14826) /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_5 (20-394). E-value: 2.6e-67. Score: 219.2. Matches aSDomain: nrpspksdomains_BP422_RS08955_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (rule-based-clusters) DegT_DnrJ_EryC1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:TIGR01976.1" /locus_tag="BP422_RS08955" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08715" /product="cysteine desulfurase-like protein" /protein_id="WP_236841437.1" /sec_met_domain="Aminotran_5 (E-value: 1.6e-64, bitscore: 216.6, seeds: 34, tool: rule-based-clusters)" /sec_met_domain="Aminotran_1_2 (E-value: 4.4e-05, bitscore: 21.3, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.7e-08, bitscore: 30.6, seeds: 38, tool: rule-based-clusters)" /transl_table=11 /translation="MEKVREQFPALQRTYKGKPVVYLDGPGGSQVVKSSMDAIYRYMAN GGANLHGSFPTSKETEAILADAKQAVADLFHVRPLEVAFGANMTTLTFAIARALGRHWK EGDEIIVSEMDHRANVDPWLTVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLLA VGLASNAVGTIHDLAAISQKARTKGVVVAVDAVHAVPHFSIHRDEIGADILLCSAYKFF GPHVGIAVIRKEIFEALDVYKLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFIASLGLG ESFAEKIRSGYEVIEAYENQLAEKLRKDLDAMKGVTLYQADEDAPKTPTIAFRIEGFSP QEICERLCEEHSIFVADGDFYATTLANCLGINESGGWIRAGLAPYNTHEEIDRFVQGIK AVIRA" aSDomain complement(13645..14766) /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BP422_RS08955_Aminotran_5.1" /evalue="2.60E-67" /label="BP422_RS08955_Aminotran_5.1" /locus_tag="BP422_RS08955" /protein_end="394" /protein_start="20" /score="219.2" /tool="antismash" /translation="VYLDGPGGSQVVKSSMDAIYRYMANGGANLHGSFPTSKETEAILA DAKQAVADLFHVRPLEVAFGANMTTLTFAIARALGRHWKEGDEIIVSEMDHRANVDPWL TVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLLAVGLASNAVGTIHDLAAISQK ARTKGVVVAVDAVHAVPHFSIHRDEIGADILLCSAYKFFGPHVGIAVIRKEIFEALDVY KLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFIASLGLGESFAEKIRSGYEVIEAYENQ LAEKLRKDLDAMKGVTLYQADEDAPKTPTIAFRIEGFSPQEICERLCEEHSIFVADGDF YATTLANCLGINESGGWIRAGLAPYNTHEEIDRF" gene complement(<14839..15357) /locus_tag="BP422_RS31990" /pseudo="" CDS complement(<14839..15357) /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1111: GCN5-related N-acetyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000140152.1" /locus_tag="BP422_RS31990" /note="incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /product="GNAT family N-acetyltransferase" /pseudo="" /transl_table=11 /translation="MSTTLNTALVRIQPWADHDLSLLRLLNGSAMMEHLGGPETEEQLL ARHERYVNKDGQLTSKMFSIVLLPDHTPVGSIGYWDRIWQGENIYEVGWSVLPPFQGKG IASMALASLITRINQERRHKYIHAYPSVDNPASNAICRKLGFTLQSECVFEYPPGSFMR SNDWRLEVAS" gene 15636..16148 /locus_tag="BP422_RS08960" /old_locus_tag="BP422_08720" CDS 15636..16148 /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1111: GCN5-related N-acetyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891003.1" /locus_tag="BP422_RS08960" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08720" /product="GNAT family N-acetyltransferase" /protein_id="WP_088907429.1" /transl_table=11 /translation="MNEKSIQTQRLILIPFTHRIATNILQENYEELLDLGLTLGKGWPD EDAMETIPKIIKALELTGEPTGFESWMIITQDGMKIIGDVGFKGVPNAQGEVDIGYGII EAERKKGYAYEAAKSLANWALLQPHVKKITAKCLLDNIDSAKLLVKMGFTEIKRDDTII YWSRQKE" gene complement(16224..17048) /locus_tag="BP422_RS08965" /old_locus_tag="BP422_08725" CDS complement(16224..17048) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016740503.1" /locus_tag="BP422_RS08965" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08725" /product="hypothetical protein" /protein_id="WP_088907430.1" /transl_table=11 /translation="MFRKIVHSLVCLLLVMTAGAVNVNAAEAKATGMFFIDKPLKKEGL RFQVTVTEIDNPKYDSPTYHVNTIVTNISRKPITYTTGHCYGVTTRLEAYASGDSWELP YPENEPVCPPVIQEKTLKPGRTIEQDEYFRTDELPDDLTPDYFQLNSSVHILVGPEDER KEEFVKMQTKLLPGLALNPDEIEIQSESSKLPKSYYELKVTGKASNKDIKSVTIQVFNT IITLRIDSKSGEFSTKKKVKAKGPSLQSGVLEVTYKDGTKHIYNIPIENSSN" misc_feature 17151..17164 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 21.06" /tool="antismash" gene 17303..17914 /locus_tag="BP422_RS08970" /old_locus_tag="BP422_08730" CDS 17303..17914 /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1188: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007717970.1" /locus_tag="BP422_RS08970" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08730" /product="DedA family protein" /protein_id="WP_088907431.1" /transl_table=11 /translation="MQNWMTQIIEQYSYFGILLMMALENIFPPIPSEVILTFGGFMTTQ SSLTVFGVILSATIGSVIGAIILYGIGYYLDVKKIEKIVARWGHILRIKPADIHKANEW FDRYGYWTIFFCRMVPLIRSLISIPAGMTKMNFPLFLLFTTLGTFIWNIVLVMAGHLLG ESWEDILYYFDLYSNVVYAVLAFAGIAFLIFFLRKRKADA" gene 18052..19482 /locus_tag="BP422_RS08975" /old_locus_tag="BP422_08735" CDS 18052..19482 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Amidohydro_1" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009335780.1" /locus_tag="BP422_RS08975" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08735" /product="amidohydrolase family protein" /protein_id="WP_236841332.1" /sec_met_domain="Amidohydro_1 (E-value: 6.2e-33, bitscore: 112.9, seeds: 57, tool: rule-based-clusters)" /transl_table=11 /translation="MSWAPPLFFRLGEMQLDRFVTRKRRSYYHRQRPSGCTHHCILPGF VDAHGHGGHSLFKTIATDNINDWMSIMTNTYKHYVTDDFWYYEGKLSALERLKAGITTG VSVLGSMPRSDDPIFALNHAKAYNEVGVREIVATGPCNPPWPHPFSRWVDGQKVTKEVS YEQVLAGAEAVIEALNHANNDKTRAYITPFVIVTSVNPSYPTPADQLFGLTDFDRYQAR KIREIAKKYDTRIHSDAFGGMIHLAIQDKEYALLGPDVHLQHCRGISFDEAKILAETGT NVSASPGFGQINARTPITELLEMGATVAITTDGTSPMTPFDMFQAMRRMQLLQQAALRD YYYLPPGKLLEMVTIDAARCVGWDDELGSIEAGKKADVITVNMHQAHLNPENMHVHRVV YQAVGGDVNHVIVDGELIMDERRVLTVDEKQILKQANEEANRTIARAGLEVYMQPSKYF WGHARAYLDERRFDPTKL" gene 19671..20513 /locus_tag="BP422_RS08980" /old_locus_tag="BP422_08740" CDS 19671..20513 /EC_number="7.6.2.7" /GO_function="GO:0005215 - transporter activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0006810 - transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007717977.1" /locus_tag="BP422_RS08980" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08740" /product="ABC transporter ATP-binding protein" /protein_id="WP_088907432.1" /transl_table=11 /translation="MYLTIDNVTKHFVNEEKQKVKVLDDINLEVEKGSFVSIVGPSGCG KSTLLYLIAGLDQPDSGDIHVAGNKVNKPGPDRVVVFQEAGLFPWLTVLENVTYGLKLK KMSTAKANEKALEVLKMVHLSKYVHSYPHQLSGGMKQRVAIARALVMEPDILLMDEPFS ALDEQTRMVLHKELLEIWRTTKVTIFFVTHNIREAVQLAERIVVFATRPGKIKEIIAVP AMRDGVMPDSVTVNTEQKVLSILQEEIEKVLKEEMGNDYSFKTGHLHRYDSGDMGSHI" gene 20446..21201 /locus_tag="BP422_RS08985" /old_locus_tag="BP422_08745" CDS 20446..21201 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1044: ABC transporter, permease protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020372021.1" /locus_tag="BP422_RS08985" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08745" /product="ABC transporter permease" /protein_id="WP_088907433.1" /transl_table=11 /translation="MTTALRRVIFIAMIAAIWEVTSKLSGLPSFMFPSLTQVFETLVNG LISGQITAAIGKSMGRILLGFLIAIIVGLILGYFIWRYKLVEDTLGFVVTALQSIPSIV WFPLAIIWFGLNDFSILFIVTIGATWTMTVNATSGFKNVPPLYQRVARTYGSTGFHFVR TVILPASVPQIISGLRIAWAFSWRALMAGELLGGGGGLGQLLEMGRSLGQMDLVISVMI IIAIIGTIVDNVVFSRIERNVQMKWGVHS" gene 21233..22228 /locus_tag="BP422_RS08990" /old_locus_tag="BP422_08750" CDS 21233..22228 /GO_component="GO:0009897 - external side of plasma membrane [Evidence IEA]" /GO_component="GO:0030288 - outer membrane-bounded periplasmic space [Evidence IEA]" /GO_component="GO:0043190 - ATP-binding cassette (ABC) transporter complex [Evidence IEA]" /GO_function="GO:0005488 - binding [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0042918 - alkanesulfonate transport [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007717982.1" /locus_tag="BP422_RS08990" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08750" /product="aliphatic sulfonate ABC transporter substrate-binding protein" /protein_id="WP_088907434.1" /transl_table=11 /translation="MFKKVFSTVVASLLLMGIASGCSTGGAESSEKEVRIGYFPNLTHS ATIIALEKGYFKEAFGADMKIQTKTVTNGGLFMEAMATKAIDVGTVGPGPLLNFYVKHP GYRLISGAVNGGAVLVMNGSTNITELKDLKGKKIAIPVIGSTQDVMLRKALNEVGLKPT TNGGDVELYAAAPADTAALFVQKSVDGAATQEPWGYVLENQAGGKLLLDWDQFAWGKES TNTVVAASDEFLKREGLATAYLQAHKKAVKFIQENPEESQDLIIKHLKNLTGKELSKKE VQAAFSRLEVTTAVNEKVIQEMADISQEAGYISSNKIDGLIDLKYLEAAK" gene 22308..23168 /gene="kynA" /locus_tag="BP422_RS08995" /old_locus_tag="BP422_08755" CDS 22308..23168 /EC_number="1.13.11.11" /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase activity [Evidence IEA]" /GO_process="GO:0019441 - tryptophan catabolic process to kynurenine [Evidence IEA]" /codon_start=1 /gene="kynA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015891010.1" /locus_tag="BP422_RS08995" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_08755" /product="tryptophan 2,3-dioxygenase" /protein_id="WP_088907435.1" /transl_table=11 /translation="MRPNEQGSNQPNDTSLETQIHTDFQQEMTYGDYLQLDQILSSQQR QSTHHDEMLFIIIHQVSELWMKQILHELSAANECICNHDLEPAFKMFARVSRIQQQLIK SWDVLSTLTPADYLQFRDKLGHSSGFQSYQNRLIEFTLGYKNQHVLAVYAHQPELHAKM SAALQQPSIYDAAIREMAARGLPIDPECLNRDWSQPYQPNQSVEQAWLTVYRNVNQYWD LYELAEKLVDIASQQQQWRFNHMTTVERIIGQKPGTGGSSGVMYLRRALDHRFFPELWS LRTLL" misc_feature complement(23296..23309) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 19.65" /tool="antismash" misc_feature 23296..23309 /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: weak, score: 20.31" /tool="antismash" ORIGIN 1 cgatttttgg cttggtggcc cttgtcttgg caacaccgtt ggctgctatt atgggttttc 61 tcggactgtt tttttatgtc gtgccttata cgatgtggac aaaaagaaga accgtttaca 121 atacggaggt aggaagtatt tctggggcaa tgccgccgct catcggttgg gctgccattc 181 acccggatat cacgcatcct gctatccttg gacttttcat catcatggtc atttggcaaa 241 tgcctcactt ctatgcgatt gcgattcgca agcatgatga gtacaaggca gctggggttc 301 ctatgttgcc tgtggtcaaa ggtgcaagac gtacctatat tcaaacaaat gtttatttgg 361 ttattttaat cgcaagcagt tttctatttt ggtcattaag cgctggtctt acgtttatgg 421 ctctgctcct gaatgtttta tggctggttc tgagtgtttt tggataccgg aaaatggatt 481 cacagaaatg gtctaaaacg atgtttattt attcgctgat tcatatgacg gtgctgttct 541 caacggtgat tatttactcg ctgatgggga ttattttcaa gttgtagaga tgaatgctga 601 taataattat ttttccagtt aagcatgtta aaaatttgta tataattatc ggttgatgta 661 gatttggaaa atattataat atgaaaatta gatgacccga ctagtatctc atcggtgtca 721 tttttttttg cttgaaaaga gtaaaaataa aatatgattc aggacttgtc agagattttc 781 agttcccagc ctttgataaa gaaaatcctg cgcaaaaagt ggaaacgaac cttcatggtg 841 agagcatcct ttttgcagaa cgatccgaac atgccagtaa aattagtaga cgagttattt 901 ggtgaaaagg ttaaaactgc tttaggaaaa ttaccgggaa ccgtcattgt ggacgctgga 961 tacggcggga tttaggaatc atgaattatt tatatttcat ggaggataga tgtaatgata 1021 agacaaaatt tagagatagg aaatattcca gcaattttgt ggggggacaa atcagataag 1081 ttatttatag tagtgcatgg taacatgtca aataaggcag atgactcgat tattgtattt 1141 gcagaagaag cgacagcagt aggttatcaa gttcttagtt ttgatttgcc tcaacatggt 1201 gaacgtaaag atgatactta tctttgtaaa gttcaaaact gtgttcgaga ccttaataaa 1261 attatgacat atgcaaaatc gttatcaaat catataagca tttttgcttg tagcatggga 1321 gtatatttca gcctattaga atattgccat gagccattga atcagtgttt gtttctctct 1381 cctgtggtaa atatggaacg tataatagat aatatgatga cgtggtttaa cgtaagtgag 1441 agtagactaa aaatagagaa agaaatttcc acacctattg gacaaactct ctattgggat 1501 tactactgtt atgtgaaaga acatcctatt gtagcttgga ataatccgac ttcaattctc 1561 tatggttcag gagataactt atgtgagttt gacattgtat ctgaatttgc taaacgcttt 1621 aactgtaatt tgcaagtaat ggagaatgga gaacactatt tccatactca ggaacaattg 1681 cagtatttca gacaatggct aaaaaagcat atatactaaa tgattaaggg aagtcaaaat 1741 ggtttccctt aaaagttaaa taatttcaac attattttaa gtcaatcgaa atataaaaat 1801 cttttctgtt gacataaaat gtgcccttca ctattataaa cgtaaatgat aatcattatt 1861 aacatacaag aatggagata ccactttatg tttggatcaa ctaagaaggc cgttttattg 1921 atggtagctg ttattctact cttatcaaca actctattgg ggtgcacgaa acaggaaaca 1981 gagtcaaatg gtgaaaacaa ggcggcgtca gcggaaaagg taatcacttt atcttggccg 2041 agggatatcg gaccgatgaa tcctcataca tataaccctt cacaattatt tgctcaatcg 2101 atgatctatg aaccgttggt tagctataag gaagggggca aacttgaacc ctatcttgca 2161 gaatcatggt cgatctcgaa ggatggcaaa gagtatacct tcaagctccg tcaaaatgta 2221 aaattttcgg acggaacccc gtttaacgca gctattgtga aaaaaaactt tgatgctgta 2281 atgaagaacc caaaattgca tagttggctt ggcgttatta atgctcttga caagacagag 2341 gtagtggacg agcaaacttt caaaatgact ttaaaggaac cctattaccc tacattgcag 2401 gatttggcac tagtccgtcc ggttcgattc ctgggtgaag cgggtttccc ggatgacggc 2461 gacacttcca agggcttaaa aaagccgatt gggaccggac cgtggatgct ggccgattac 2521 aagaaagacg aatatgccgt gtttacccga aacccaaatt actggggcga gagtccaaag 2581 attgataaag taaccgtaaa gatcattccc gatgcagaga cgcgcgtaat ggcttttgaa 2641 aaaggtgagc tggatttgat ctatggtgaa ggagtcatca gcatggattc ctttaatcaa 2701 ctgaaagaat cgggaaaata tgtgacggag ttatccgacc ctgtcggaac gagaagcttg 2761 cttttgaata cctccaatga aaagctagct gacctgaggg tacgcatggc cctccagcac 2821 ggatttaaca agcaagcaat ggtggaaggc atcacgctag gtctggagga gaaggcggac 2881 aacatcttgt ccaaaaactt cccgtacacc aatatggatg tccaacaggt cgaatacaat 2941 gtggagaaag cgaatgctta tcttgatgaa gccggatgga agcttcccgc aggcaaaact 3001 gtacgggaga aggacggtca accgcttgag ttggaattga tctatgataa gaccgacccc 3061 attcaaaaag cgatggcgga aaccatgcaa gccgagtggg gagcgattgg tgttaaactt 3121 aacattacgg gtcttgaatt gacggttcaa attaaacgcc ggaaagcagg cgagtttgac 3181 ttggatttct ggtacaacta tggagcgcca tatgatccgc actcgttcat taatgttgtg 3241 gcagaaaaag gatggggcgt ttcggaagca cattcgcgct tgtctatgaa acaagaatta 3301 gatcaacaaa taaaagatac ccttgcctca acggatgagg caaagcgcga acagctttac 3361 gactccattt tgagaacttt gcaggagcag tcagctatcg ttccggtgtc ttacatcaag 3421 aaaactgttg tttaccagaa aaatgtgaaa gactttagct tcccggcgaa tagggatgaa 3481 catccattct acgggattgg tatcagcaag taatcggcag ggaggcaact catggtcagc 3541 tatatcggga agagagctct cgctatcatt ccaattgttc tctttgccat tctcatcacg 3601 tttgtactca tccatatctc accggtggac ccggctgagg cttatttaac cgcagcccat 3661 attcatccga ctgaggagtt attggctgag aaaagacatg aatttggctt ggatcagcct 3721 ttgatcgtac aatattttca aactgtcatg aagatttgcc gacttgattt cggcagatct 3781 tatataacga atgagccggt ttgggatgag gttacggccc ggatgcctgc gaccattcaa 3841 ctcgccgtca gcagcatttt gttcgccatg attgttagta taccgctcgg tttttttgtc 3901 agcggtttat aaaaacagcc tgattgataa tttcagcagg ctgctctctt ttttcggcgc 3961 ttccattccg caattttggc ttgggtactt attgattttt ttcttttccg tcaaactgga 4021 ctggcttccg gtagaaggaa gagggtcgtg ggagcatcta gtgcttccga ccatgacgtt 4081 gtcgttggca atgatcgcga tctatacccg tcttctgcgc gcgagtgtgt tggaacaatt 4141 gcaggagtcg tatgtcttat atgccaggac tcggggcatt aaagaaaaag tcattatggt 4201 gaagcatgtg ttgaaaattg ccatttcacc ggtgattacc ggtttgggca tgaatttcgg 4261 caaattgctc acgggaacca ttatcgtgga gcaagttttt tcctggccgg ggttcggacg 4321 ctattttgtc gaggcgattt ttaatcggga tattcctgtt atccaatgct acgtattcct 4381 cgcagcctgt ttgttcatcg tgtgcaacct gattgttgat cttgtccagc tgtatatgga 4441 tccccgaatt tctttgaaag gaagaaccga ccagtgattc cgcatatacg gaccgttctc 4501 aagggacaga aaaccataac ggtatgctcg gtcatattac tggttttcgc cattattacc 4561 gttttggctc catggatttc acctcatgat ccaattaaag tgaatgtagc gatgaagttg 4621 aagccgcctt gcaccgagca tttgctgggt acagaccatt tgggacgtga caatctttct 4681 cgtcttctgc atggagcccg catatcgctg gggtttgcct tcttgatttt cgtttcctcg 4741 ataggaatag gcttgatcgt cggaaccatt gccggttaca aaggcggttg gattgataca 4801 gtactgatgc ggttttgcga aggggtcatg gcgtttccga atcttgtgct ggttttgggg 4861 attgtcggag tgtttggacc tggattgata caggtagttt tggcgttgat gctggtgcaa 4921 tgggtatact atgcccggat gttccgaagc atggtcgtca gcttgaagga acgcaatttt 4981 attatcgcag cccgaattag cggctcttca caatggaaaa ttatcaagca gcacatgatc 5041 cccaatatac tgcctccgat tctcgtgatg ggtacattgg aaatgggatg ggctatcatg 5101 gacatctctg cgctgtcgtt tttgggcttg ggcattcagc ccccaacacc tgaatggggg 5161 gcaatgatcc acgaaggaaa aggctttata cgaagtcatc cggaattaat gctgtatccg 5221 ggactgatga ttttgtttgt cgtgattaca ttcaatgtac taggggaagc tttgtcggaa 5281 cgatttgggg taaaacgacg tttttgaatg ggaatgaggc cagtgatgga agaaccacgc 5341 aaagtattgc aggtgagcgg tctgcatgtc aaggtaaagg cagagcaggg aatgctttct 5401 ctgattcagg atattcattt tgatttgaaa cgcggtcaag tgctcggcct tgtgggcgag 5461 agcggcagcg gcaagactgt cacctgcaac tccctcctgc aacttctgga ccagaaaaat 5521 accatcgtag aaggcagtat tcaattgaat ggccgagagc tgaacggctt aaaagcagag 5581 gagatgcgac gtatacgcgg gaaagaaatc gccttcatta tgcaaaatcc gatgagtgcc 5641 tttacaccgg tgtatacgat aggtatgcaa ttcattgaaa cgattcgtac ccataccatg 5701 ctcacaaaaa aacaagcaat cgagctggcg gtcacttcca tggaagatgt gaatttgcct 5761 gatcccccca agctgatgaa cttgtacccc tttcaattga gcgggggaat gctgcaacgg 5821 gtgatgattg ccatttccat atgcctgcga ccatctgtcg tgattgccga tgagccgact 5881 acagcgctgg acgtggtgaa tcaattgcaa gtgttgaggc agctggaccg attgcgcttg 5941 gaatacggca catcgattat gctgatttcc catgacttgg gtgtcatttc ggaattggct 6001 gacgaagtcg cagtgatgca gcatggacgg atcgtagagc aggcgaatgt ctttaagctg 6061 ttcgatcatc ctcagcatgc gtatacgaaa aaactgctga atgccagacc agcctttcct 6121 ttacatcagt tgaataggga atctgtttaa ttattttctc ctgcatagtt ttgctgtcta 6181 ttctatgaaa aacggaaaca gggggtgagc gcatgctgct tcaggtaaaa gacgtaaccc 6241 attcttatgg cgtaccgagg ctgttttggc ggtcagatcg acgagtgccc gtcctctccg 6301 acatttctct tacgattgaa caaggaatgt gtctgggtct actgggaacc agcggtgcag 6361 gaaaaagtac attgggcaaa gtgattctgg gcttggaaaa acctcgacag ggacaggttt 6421 tttttcaagg tcacgatctg tatcgcacgg atatacaaac tcgtaaagcg ttgcgacggg 6481 atcttcaagt cgtgtttcaa gattgctact catcggtaaa tccacggatg acggccgaac 6541 ggattatcgg ggaaccgtta gataactatg agagcttgtc cttgaacgag caaaaacgaa 6601 aaatcggaga gttgctggaa atggtcgggt tgaatccaga ggacatgcgg aaatacccta 6661 accaatttag cggaggacag ctccaaagaa ttaatatcgc gcgggcaatt gccttgaaac 6721 ctaaaatgat tgtattggat gaatcggtaa gtagtttgga catggtgaat caaacccaca 6781 ttttaggctt gttacgcgaa ttaaagtcgg tattcgggct ttcataccta ttcatcacgc 6841 acgatataaa agctgcctac tctatttgtg atggactcgc ggtactcgaa aaaggggaat 6901 tggtcgagat gtgcgacgat aaggatcaaa tttttgcctc ctcccatgcc actgtgagaa 6961 gtctgatttc atccattctt tccgagcatc cccgacaccg ttctctttct tcagacgaag 7021 atccatacta attgacttaa accatatatt tgccgcatcg gctaggtaat actttaaaaa 7081 actttaggca aacatcgctt taaagttttt ttatttgggc ttatttagat ggcctattac 7141 aaaggtgttc attatgactg catatgttaa atttgcttca caattcccgt tcattgcata 7201 aaaaaaaaga ccaacatagt acatatcgcc ggtctttgac tcatggtcag ctattaatgg 7261 ggctctaaca caaagtaata tggtttggag agaagattgt gcaagtgatc gcgtactggc 7321 tttcatgctg ttcttccgag ccctcttttt gtttctcctc gtgaattctt ccagcgccca 7381 taatctgctg aaaatgacag cagttatggg cagaaaggaa gcaacaaagg caggctaaaa 7441 atcaataatg caaagtgaag ctgaaaaata agggaagggt gtcccctcaa gtagaattat 7501 ctacttttgg gacaccctct tttgtatgat gaaaaaatgt atagttaagc accttaaaaa 7561 tgggcgcatg atgatggaac aaatacccaa tgtcgcttca taaatctaga gtagctccat 7621 gaagtggcgg aggtgaagat gaatggatga tttcaaaaaa gagctaaaaa aactaaaggc 7681 ttccgaaata aaagcggatc aagtacagcg ttgggataaa caaaagatga atgaagcgac 7741 gcttgttcgc gggcgatgtg gatgtggtag atgtggttgt ggccgctgcg gacgttgtag 7801 ttgcagttgt tcctgttctt gctcctgctt ctgtagctgt tcctgcttct gcacatgcag 7861 ctgcacttgc ttcttcccat gctttatcgt atgaatggcg atatcttcta acgataaact 7921 gaatgaagcg ccctgccagg atgacgtctt ggcaggggtt ttgtttttct gctggcatgt 7981 gagacaacgt attctacata aaatgacgat gacacatcat gtcgcaaaag ggctgatctc 8041 gcacaataag ggggaggaga atggttaggc tgaatccttc aatgcgcata aaagtgaagc 8101 gggatacggt ttatctgcct gattcagatg ggagtgtata ctttcggaac aacatcggaa 8161 catttcgaat gaagggggag atgattgaac gatgggttga ccagctcatg ccgatgttta 8221 atggggagta cacgctggcc caattgaccg acgatttgcc ggaagaatac caacaacaaa 8281 tataccaggt ggcagacacg cttttacaaa atggatttct tcaagacatc agtcgagaga 8341 agccacatga actatcgcct gaaatcatat cggcctatgc agaacagatt gaatttttgg 8401 accagtttgg cggatcgggt ggatatttat ttcaaaaata tcgagcggaa aaagtattga 8461 tagttggggc aggttccttt cttctttctg ttgtccatgc cttgctagaa tcgggctgcg 8521 ttcaattcca ttacgtcatc gcgaatgaaa ctcccacgaa tcgagagcga ttggacgcaa 8581 tcatcgagca tgctcgcagg aaagacccgc acgtgaagct ggaggaactg aaaccagcgt 8641 catgggggat tgcagagtgg tcggaggcta ttgagccttt cgctgctatt ttgtacacct 8701 cagcgcaggt aaacaaggat gaaatgagcg tcattcattc cgcgtgcaga gagagggaga 8761 aagtatttgt tcctgccgtt tgtctgatgc aaaaaggaat agctggaccg ttgattcatc 8821 ccgaatcagc agcttgttta gaatcggctt ggcggcgttt gcaccgacag actttatgtg 8881 cggatcccga tctacatcca ttttcaatga cggcagcagc gatcctggcg aatattgccg 8941 tgttcgaatg gtttaaacat gtgactggtg tcaatgaagc tgaggatgaa aacaaggtgt 9001 atgtactgaa tctggagaca ttggaaggaa gctggcgatc attcctgcct catccgttgg 9061 tgaataaaga gatgagcctg gaggtattga atagtaagga gcttgaatct cggctatcca 9121 ataagacgga accaaaggaa ggactacagt ctctgtttca gtcgtggacc tcatcggata 9181 caggaatttt tcacagctgg gatgagggtg agctcacgca attaccgctc acacagtgta 9241 tggttacggc cgtcgatcca gtctcggaag gtccggcgga gctgatgccg caagttgtct 9301 gccctggcta tacccatgaa gaggcacgaa gagaagcggg acttcttggg gcagaaatgt 9361 acgttggtag aatggtgaag cacctcgtaa ccatagacac tgactttcga gctatgggaa 9421 atggcaatat gggagtcggc gcaggggaaa cgccagcaga agggcttaat cgtgcactgc 9481 gacattgctt gacgctcatg tatgtatcag aaatgaaagg gagacaacca acagcgagac 9541 cagtatacgc tgacacgatt gctgatgaac catgccaatt ttatatccgg tcatttacta 9601 cgttgggtga aaaaccaacg attgcaaagg gctatgaggt gtacggattt ccggtgtatt 9661 gggtgggaac gcgcacggga tggtacggga gtattggctt gcaggaacga gacgcattac 9721 gatcagcgct gatgtatgcc ttgcaacaga ttcagactcc aaccacccaa gtgtccaagt 9781 atgtcctgac agcgcaatct gttggattgg cgggtgaagc catcgaagtt gcactcaaca 9841 gcgttcagga agaatcggaa aaagaagtct ggaaacaagc tgccgaggtg ctggcccttc 9901 atcacctttc tccgctagtc atgaatgccg cggtggagcc tttcctggaa gaagaccttg 9961 gcggagtatt cgctttgctg ctctcgcagg aggtgcctcg atgagcgctg acattcttat 10021 cattggagac ggagtactgg cagagctggt ttcggaacgt ttgaggaagg actatcgtgt 10081 gtggcacagt gaaaacatgg agtctgcgac aagcggagca gatttggctc tcctgttgca 10141 cgatacgtac cgtcccgctt tgcatttgca ggcagaaaat aactttcgac aagccaacat 10201 cccatggctg cgcggctttg tttcatttgg ggaggccatc gtaggtccgt tggttcgtcc 10261 aggtcaaaca gggtgctccc agtgtgcaga tatgcggcga ctgatggcgg gacgtgatcg 10321 caaagagatg tggaaggtac agcacatgct gagtgaaaaa ggcggcatac tgcgtgaccc 10381 gtgggcatcc cgctctggat tgttacaggt ggcataccat gtaagcgcgg aggttgatcg 10441 tatagtagaa ggcaggcaag cccagttatc agagcatatc cagtttattg atttacaaac 10501 attgacaagc acgcgtcatt tctttttgct gaatccgtta tgtccggtat gcagtcagct 10561 gcctgaggat tccgaagagc agacgagaat tcgcttgaag cctatcataa agcaaagtcc 10621 agacagctat cggaccaaat ccatcgccga tttaaaacaa gctctctcca ccgaattttt 10681 agattcccgt actggatttc taaatgggaa agtacgtgat cttgtctctg tgttcgcaga 10741 tgtcagtgtc aatcttccgt tattttcaca tgacgagggc acggcaggca ggtctgtttc 10801 atacgcggat agtgagataa cggcgatttt ggaaggaatg gaaagatatt gcgggttgat 10861 gccgcgtggc aagaggacga tggtacgcga ctgctatgcc aaccttgcgc cgcatgccct 10921 tgatccgacg acggtgggaa cccattcaga agagcagtat gccctgcctg attttccgtt 10981 tcagccgttt gaccccaaac gggaaatgaa ctgggtatgg gggtattctt ttaaagaaga 11041 gcgacccatt cttgtacccg aactcatggc ctactacagt atgggattcg gggagggagt 11101 tgtatttgag agctccaatg gctgtgcgtt aggcggcagt ttggaggagg cgatctttta 11161 cggcatcctc gaagtggtgg agcgagatgc tttcttgttg acctggtatg cccaattgcc 11221 attgccacgc ctcgatcctg ctacggtcaa tgatcgggaa ttgcttctgt tgatcgatcg 11281 aatgcagacc gttaccaatt acgatttgta cttgttcgat gcgaccatgg aaaatggaat 11341 tcctgctgta tggacgattg cgaaaaaccg cggagcggaa ggcttgcacc tcgtttgtgc 11401 agcaggagcg catccagacc ccatccgcgc tgtaaaaagc tccatttacg aaacggctgc 11461 tatgctcatg cctttgacag acaaatacga agcgaaccga gacaaatact tgcgcatgct 11521 tcaagattcg tccttggtga aaaagatgga cgatcatgcg atgctttaca gcttgccgga 11581 agcatcggag cgcttatcct ttcttatgga tgattcacgt ccaatggtct ctttcgctga 11641 acaattccct agaagaaacc aaaatcgtga tctaacagac gatttgcggg agttgctcgg 11701 tgtgttccaa aagctcgatc tcgatgtcat tgtggtggat caaacgacac cagaggtagg 11761 gcgccacggc ttatcttgcg tgcgcgtatt gattccgggc atgcttccga tgacttttgg 11821 ccatcatctc acgcgagtaa cgggattgaa aagagtattg gaggtccctg tgaaactggg 11881 ttacgcgaaa caaccactgc gtgtagatga gttgaatcct tttccgcatc cgtttccata 11941 acatgcatct gggagtgagc cggatgagtc tcgaaaattt cttgtaccgc cttcattttg 12001 atacagaaaa tgccaggtca agcgatctcg aagtggattg gggggatgcg ccactgacat 12061 acaaagtgta cagggggcta cctgtcattc cattaccaga agatgttcct ctttcacttg 12121 tagatcaaac agtttcacaa gagatgtctc tttctcaatt gggtgcttgg ctatggtata 12181 gctacggact gatccaaatc agccaatcgt tattaaccac gacctcggca gatgcagaat 12241 ctgagtcgtt tttgccactt gtaacgaatc gaagaccggt tccgtctggt ggaggactct 12301 acccgagtga gctgtacgtg tatttgaagc tgtcgagtat tcctccaggt ctataccact 12361 acgatgtggc ccatcacaga ctcgtacaat tacgcgaagg gaattttgat cacgtcctta 12421 gccgagcact gggtggcagt tgtccggtac atgcatgctt tggagttgcg ttcgtatcca 12481 tctatttttg gaagaacttt tttaagtacg atgagttttc ctatcggttg cagggcctcg 12541 atgctggtgt actgctggga caattgcagg aaatggcaaa ccagttcggt gtgacgaccg 12601 cggtacatta ccagtacctc gataaagcga taaataaact gctaggattg tctgccgatc 12661 aagagagtgt atacgcggta gttcccttat cgcttcaaga agaaggggag aggcattcgc 12721 actcaccggc actatggaca gagcgaggag acgagacggc aagcgaggta atcagagaac 12781 tgcctgagca aaagcatatg catgttatac gctcaaaaag aatgagacaa tatcctgcgc 12841 tcttgcaaat gaatgaagct gccatgcagg aatctaccca tgcatttaga cgatattcgg 12901 atcagttgga aagcaagtgg tctcgtcgtt ttgatgagcg aatccttctc ccgcgtttgc 12961 agaaaccaag ctatgatctg gcgcaatatt gccgggagcg tttttcacca gaaatggact 13021 ttatcaggaa gaaaacagac cagaatcagg tagcgcgtat catggaaatg acgatgagtg 13081 ctttatcgta tggcaatgat ttgggaaata atcaagaagc agcgtgggga aggctttctc 13141 tttttgtaag cattcatcag gtagaaggga tacaagatgg ggcatacgct tacaaaccac 13201 tggagcacgc tctttatccg attgtttatg gagatttacg agcacgcctt caagacggaa 13261 tgaccctgga caacgtgaat ttgtatcaag ggccgctctg ctttcatgtg gcgggtaaac 13321 gcgatcattt gatcaatcag ctagggttta gaggatatcg cattcagcag atggaggcgg 13381 gaatcgtcgt gcatcgcttg cttttggcag cgttcacgtg tggaatgggc ggtcacccgc 13441 tactcggatt tgacgtggag aattgcgatg atctttacaa cctagagacc gaagagaaaa 13501 cctgcttgat tcaaattccg gtcgggcact atcgcccccg cgccagattt cagaccgggc 13561 ttcatggata aaaacgtgga agacccgagt cgcgttgacc cgggtcttgt attatgctcg 13621 tataacggct ttgatacctt gaacgaaacg gtcaatttcc tcgtgggtat tgtacggtgc 13681 cagccccgct cgtatccagc cgccactttc attgattccc aaacaattgg cgagtgttgt 13741 cgcatagaag tccccatccg caacgaatat gctatgctcc tcacacaatc gctcacatat 13801 ttcttgggga gaaaaccctt cgatccgaaa agcgatcgtc ggtgttttcg gtgcatcttc 13861 atccgcttga tagagtgtga cacccttcat tgcatctagg tcttttcgca gcttttctgc 13921 cagctgattt tcataagctt cgatcacctc gtaaccagag cggatttttt cagcgaagct 13981 ttcaccgaga ccaagcgacg caataaattc gatagcgggt ctgattcctg cgatcccttc 14041 atgattttgt gttccggtct ccagtttatc tggataagaa gagggggcag gaaccaattt 14101 gtaaacatcg agtgcttcaa aaatttcttt acggatgaca gcgattccca catgtggacc 14161 aaaaaacttg taagcggaac agagcaggat atcggctcca atctcgtcac gatggataga 14221 gaagtgaggg accgcatgca cggcgtcgac agcaacaacg actccttttg tgcgtgcttt 14281 ttgggaaatg gcagcgagat catggatcgt tccgacagca ttggaagcaa gcccgactgc 14341 caaaagtctg gttctggaag taaggagggt atcgagctca tctagttgta acgtaagtgt 14401 ctctttattc acctttaacc accgaacggt cattccgcga tcagcggcaa cagtcagcca 14461 cgggtctaca ttggcgcggt gatccatctc ggagacgatg atctcatccc cttctttcca 14521 atgtcgacct aatgcacgcg caatcgcaaa ggtcagggtg gtcatattcg caccgaaggc 14581 tacctctagc ggcctcacat ggaagaggtc ggctacggct tgcttggcat ctgccaggat 14641 ggcttctgtc tccttgctcg ttggaaagga gccgtgtaaa ttcgctccac cgttcgccat 14701 atagcgatag atcgcgtcca tggaggattt tacgacttgc gagccgcctg ggccatccag 14761 ataaacaact ggcttgcctt tgtacgttcg ttgtagggcg gggaattgct cacggacttt 14821 ttcaatgggg aaatgtcctg acgcaacttc taatcgccaa tcattggagc gcataaaact 14881 tccaggaggg tattcaaaga cgcattctga ttgcagagtg aaaccgagct tacggcaaat 14941 ggcattcgag gcagggttgt ccacggaggg ataggcatga atatacttgt gtcttcgttc 15001 ttggttgatg cgtgtgatga gtgaggctaa agccatagag gcgattcctt tcccttgaaa 15061 ggggggcagg acgctccagc ctacttcgta tatgttttct ccttgccaga tgcggtccca 15121 atagccgatg cttccgacag gggtgtgatc tggcagcagt acgatgctga acatcttgct 15181 cgtaagctgt ccgtccttat tgacgtatcg ttcgtgccga gcaaggagct gctcctccgt 15241 ctccggacct ccaagatgct ccatcatggc tgacccattc aaaagacgca gcaaggaaag 15301 atcgtgatcc gcccagggct gaatgcggac aagcgcagtg tttagcgttg tggacatttt 15361 ttcactcctt atcaactgga tttccgggtg tccatcctca ttcgttatct ctcattattc 15421 ggaaaagata cccattaatc aatcttccat tcgttctgag aaagagggat ggaaaatcat 15481 gctataatag tgatgcccga gtgattctta ttatcggagt atggaaagag tagctgaggt 15541 ggaggaatag accctttctg aaaaggcata tgtcgagtaa atccaacgta aatattttca 15601 ccgacaataa aggaaagagg aaggggtacc tgtccatgaa tgaaaaaagc attcaaacac 15661 aacggctcat attgattcca tttacacata gaatagcgac gaatattttg caagaaaatt 15721 acgaggagtt attggatttg gggcttacat taggcaaagg ctggcctgat gaggatgcga 15781 tggaaacgat ccccaaaatc atcaaagcac tcgaactcac aggggaaccg acaggatttg 15841 aatcgtggat gatcattaca caggatggca tgaagatcat cggggatgta gggttcaaag 15901 gtgtcccgaa tgcgcaggga gaagtggaca tcggctatgg aattattgaa gccgagcgaa 15961 aaaaaggcta cgcgtacgag gcggcaaaaa gcttagcgaa ttgggcgttg ttgcagccac 16021 atgtgaaaaa aattacggcg aagtgcttgc tagataacat agattcggca aaattattag 16081 tcaaaatggg ctttaccgaa ataaagaggg acgacacaat aatttactgg tctaggcaga 16141 aggaatagca cggaagaaca gatgcagagt ttcacacgaa aaaaaggacg cacacatggg 16201 cagtcctttt ttcatggaga acatcagttg ctggaatttt ctatgggaat gttgtagata 16261 tgtttcgtgc catctttata cgttacttcg agtacacctg attgaaggga cggacctttt 16321 gcttttactt ttttcttcgt ggaaaactct cctgacttcg aatcgattcg caacgtaatg 16381 atcgtattga agacctgaat cgttacgctt ttgatatctt tattagaggc tttccctgtc 16441 actttgagtt cgtaatacga tttagggagc ttgctcgatt cagactggat ttcaatctca 16501 tctggattga gagccagccc tggaagaagt ttcgtctgca tctttacgaa ttcctcttta 16561 cgttcatctt cgggtccaac gaggatgtgt acggaagaat tcaattgaaa atagtctggc 16621 gtaagatcat ccggcagttc atctgtgcgg aaatattcat cttgctcgat agttctcccg 16681 ggctttaagg ttttttcctg gatgaccggg ggacatacag gttcgttttc agggtaagga 16741 agctcccaag agtctccaga ggcatacgct tctagtcgtg ttgttacacc gtagcaatga 16801 ccagtcgtgt atgtgattgg tttccgcgaa atattggtga caatcgtatt tacgtggtac 16861 gttggtgagt cgtattttgg attgtcgatt tcggtaacgg tcacttgaaa ccgaagtcct 16921 tctttcttca atggtttgtc aatgaaaaac atgccggttg cttttgcttc ggccgcgttt 16981 acattcacgg cgccagccgt cataaccagt aaaagacata cgagtgaatg gacaatcttg 17041 cgaaacacac agttcacctc ctcacgattc gtttttgagt aatgtgcatg gaggcacctt 17101 ttaaatattc catatattac ctccctttgc aatgtttttt gctcaggaat attttaaatg 17161 aaaattttca aaggaaaggt aacccaagac ttccttcttt cgtattgaaa taaaggaaaa 17221 gatgatcgct tttcattgaa ctatgcaacg cgtgtctcta tactggagag ataagcattg 17281 gtaaataatt gtgagggata gtatgcagaa ctggatgacc caaattattg aacaatatag 17341 ttacttcggt atcttactga tgatggcact ggaaaacatc tttccaccca taccttctga 17401 ggtgatcttg acattcggtg gatttatgac gacgcaatca tccttaacgg tttttggcgt 17461 aatcttgtca gctacaatcg gttcggtaat cggggcaatc attctctacg gaatcggtta 17521 ttacctagac gtcaaaaaaa tagagaagat cgtagcgaga tgggggcata ttctgcggat 17581 taaaccggca gatatccata aagcgaatga atggttcgac cgatacgggt actggacgat 17641 ctttttttgc cgtatggtcc cattaatcag aagcctgatt tccattcctg caggtatgac 17701 caaaatgaat ttcccgctgt ttttgttgtt tacaacactt ggtacgttta tttggaacat 17761 cgtcctcgtg atggctggtc acttattggg ggaatcgtgg gaagatattc tgtactactt 17821 cgatctctat tccaatgtcg tttatgctgt actcgcattt gcggggatag cgttcctcat 17881 ttttttcctt cgcaaacgaa aagcggatgc ctaaaacctt caaaccatct ttcctacaag 17941 ggaaggtggt ttttccattt ggaaccaaga ggtaaacata ttgcaaaaag tcgtaaattt 18001 cttgcaaata caagatgtca aaattgagct aaggtgtagg gaggggaagt agtgtcatgg 18061 gcaccgccct tattctttag gctgggggag atgcaacttg atcgatttgt tactcgtaaa 18121 cggcgtagtt attaccatag acaaagaccg tcgggttgca cgcatcattg tatattgcca 18181 ggcttcgttg acgcacatgg tcatggcgga cattcgttgt tcaaaacgat tgcgacggat 18241 aatatcaacg actggatgtc aatcatgacc aacacttata agcactacgt gacagacgat 18301 ttctggtact acgagggaaa gctgtcagca ctggagcggc ttaaagctgg gattacgaca 18361 ggtgttagcg tcctgggctc gatgccgcgc tcagatgatc cgatctttgc cttgaatcac 18421 gccaaagcgt acaacgaggt tggcgttcgt gaaatcgtag cgacaggtcc atgcaaccca 18481 ccgtggccgc atcccttcag ccgctgggtc gatggacaaa aagtaacgaa ggaagtcagc 18541 tatgagcagg ttctcgctgg agcagaagca gtgatcgaag ccctgaatca cgcgaataac 18601 gataaaacca gagcatacat aactccattt gtcatcgtga cctctgtcaa tccgtcctac 18661 ccgacaccag ctgaccaatt gtttggctta acggatttcg accgttacca agcccggaaa 18721 atcagggaga ttgcgaaaaa gtacgacacg cgcatccatt ccgatgcttt tggaggcatg 18781 attcacctcg ccattcaaga caaagagtac gcgctgctcg gtccagacgt acacttgcag 18841 cattgtcggg gaatctcttt tgacgaggcg aaaattttgg ccgaaacagg aacgaatgtt 18901 agtgcttctc ctggttttgg tcaaatcaac gcacgcaccc cgattacaga attgctggag 18961 atgggagcga ctgttgcgat cacgacagac ggcacctcgc caatgactcc ttttgatatg 19021 ttccaggcca tgcgcagaat gcagctgttg caacaagcgg cgctgcgtga ctattattac 19081 ctcccgccgg gtaagctgct ggaaatggtc acgattgatg cggcacgctg tgtcggttgg 19141 gatgacgagt tggggtcgat tgaggctggt aaaaaagcag acgtcattac tgtaaatatg 19201 catcaggccc acttgaatcc cgagaacatg catgtccatc gtgtcgtcta tcaggcagtc 19261 ggcggagatg tgaaccatgt cattgtcgat ggtgagctga ttatggacga gcgccgtgta 19321 ttgactgtgg atgaaaagca aatcctcaaa caagcgaatg aagaggcgaa tcgcacgatc 19381 gcgcgggcag gtctggaagt ctacatgcag ccaagcaagt atttctgggg acatgcgcga 19441 gcttatttgg atgagagacg atttgatccg acgaagttgt aggggaaaaa agagtagtta 19501 aagaagacga cgtgtaatgc tgcacataaa ctttggatac cgcattaaat aggagaaggt 19561 gaccaccgcc ttcccttttt tattggatta tagttgacaa aaacgatagg attaatcatt 19621 atttattcat aatacccatc gacaaagttg gaataaaaag aggtgcagcc atgtatctga 19681 ctattgataa tgttacgaaa catttcgtaa atgaagagaa acaaaaagta aaggtgctcg 19741 atgatatcaa tcttgaagtg gaaaagggca gcttcgtttc cattgtcgga ccctctggct 19801 gtggaaaatc gacgctgctc tacttaatag ccggtttgga tcaacctgac agcggtgaca 19861 tacacgttgc tggcaacaaa gtgaataagc ccggtcccga cagagttgtc gtttttcaag 19921 aagcagggtt atttccatgg ctgaccgttt tggaaaatgt tacatacggg ctcaagttga 19981 agaaaatgtc tacagcgaaa gccaacgaaa aggcgctgga agtgctcaaa atggtccatt 20041 taagcaagta tgttcattcc tatccccatc agctctcagg cgggatgaag caacgtgtag 20101 ccatagctcg ggcgcttgtc atggaacccg acattttgct gatggatgaa ccgttctcgg 20161 cgctggatga acagacgcgg atggttcttc ataaggagtt gcttgagatt tggcggacga 20221 ccaaggtcac gatttttttc gtcacccata atatccggga ggccgttcag cttgcggaga 20281 ggatcgtcgt ttttgccaca cgccccggaa aaatcaagga gatcattgcg gttcctgcta 20341 tgcgcgatgg agtcatgccg gacagtgtga cagtaaacac ggagcagaag gtgctgtcga 20401 tcctgcaaga agagatagaa aaggtgctga aggaggaaat gggcaatgac tacagcttta 20461 agacgggtca tcttcatcgc tatgatagcg gcgatatggg aagtcacatc taaattatcc 20521 ggactgccat cgttcatgtt tccaagtttg acccaggttt tcgaaacact cgtaaatggc 20581 ttgataagcg ggcaaattac cgctgcgatt ggaaaaagta tgggacgaat cctgttgggc 20641 tttctcattg ccattatcgt cggactgata ttgggttact tcatttggag atacaaactc 20701 gtagaagata cgcttggttt tgtcgtgact gcgcttcaat ctatcccgag cattgtctgg 20761 ttcccgctcg ccattatctg gtttggctta aatgacttct ccattctgtt tatcgtgacg 20821 atcggggcga cctggaccat gacggtaaac gcgaccagcg gtttcaaaaa tgtcccgccg 20881 ctatatcagc gggtagcaag gacttacggt tcgactggct ttcactttgt acgaacggtg 20941 attctccctg catccgtacc gcaaatcatt tctgggcttc gaattgcttg ggcattttcc 21001 tggcgggcac tcatggctgg tgagttgctc gggggtggcg gtggtctcgg tcaattgctc 21061 gagatgggac gttcacttgg acaaatggat ttggtgatat ctgtcatgat cattattgcg 21121 atcatcggta ccatcgtcga taatgttgtc ttttcgcgga tcgaacgcaa cgttcagatg 21181 aagtggggag tccattcata aaaagaaaaa tggctaagga gtgtgtcgtc acatgtttaa 21241 aaaagtgttc agtaccgttg tcgcctccct attattgatg gggattgcga gcgggtgctc 21301 tacaggcgga gcagaatcct ctgagaagga agtaaggatc ggatatttcc caaatctgac 21361 ccatagcgca acgatcattg cactggaaaa aggctatttt aaggaagcct tcggtgctga 21421 tatgaagatt caaactaaaa cggtcaccaa tggcggattg tttatggaag caatggctac 21481 taaagcaatt gatgtaggga cagtcggacc aggaccgctg ttgaactttt atgtcaagca 21541 tcccgggtat cgtttgattt caggtgcggt caatggcgga gcagtcctcg tcatgaatgg 21601 ttcaaccaat attacggaac taaaagattt aaaaggcaag aaaatcgcga ttccggtaat 21661 cggcagtaca caggatgtca tgctcagaaa agcactgaat gaagttggac tgaaaccgac 21721 gacgaatggt ggagatgtgg aactgtatgc ggcagctccg gcagatacgg cagcattatt 21781 cgtacaaaaa tccgttgacg gtgcagcaac gcaggagccg tggggatatg tactggaaaa 21841 tcaggcgggg ggaaaattgc ttttggactg ggatcaattc gcttggggga aagaatcaac 21901 caataccgtg gtagcagcca gcgatgaatt tttgaaacga gaaggattgg caaccgccta 21961 cctgcaagca cataaaaagg cagtcaaatt cattcaggaa aatcccgaag aaagccaaga 22021 cctgatcatc aagcatttga aaaatctgac tggcaaagag ctgagcaaaa aagaagtgca 22081 ggcagctttt tcccgtttgg aagtaacaac ggcggtcaat gaaaaagtta ttcaggaaat 22141 ggcagatatc agccaggagg ccggctatat ttccagtaat aaaattgatg gcttgattga 22201 tttgaaatac ttagaagcag cgaaataata tcggctgaga aggaggagat tcagcaggag 22261 gaacgagggg tggaaaggaa ttagatggga aaggaggtca tgccgcgatg agaccaaatg 22321 aacaaggaag taatcaaccg aacgacacct cattggagac acagattcat actgatttcc 22381 aacaagaaat gacgtacggc gattatttac agctcgatca aatcttgtcg agtcaacagc 22441 gtcaatccac ccatcatgat gaaatgctgt ttattatcat tcatcaggtg agtgagctat 22501 ggatgaaaca aattttgcac gaactgtcag cagcaaatga gtgcatctgc aatcacgatc 22561 tggagcctgc tttcaaaatg ttcgcgcgag tctcgcgtat ccagcagcaa ttgattaaat 22621 cgtgggatgt cctttctaca ttgacgccag ctgattacct ccagttccgt gacaagctgg 22681 gtcattcgtc cggttttcaa tcctatcaaa accgactcat cgaatttacg ctaggatata 22741 agaaccagca tgtcctagcg gtgtatgcgc atcaaccaga gcttcacgcc aaaatgagcg 22801 cagccttgca gcagcccagc atttacgatg cggcgatcag ggagatggct gctcgtggct 22861 tgccgattga tccggaatgt ttgaatcgcg actggtcaca gccgtatcaa ccaaatcaga 22921 gtgtagagca agcctggctg accgtgtatc gaaatgtgaa ccagtattgg gatttgtacg 22981 agttggcaga aaagctggtg gacatcgcca gtcagcaaca acaatggcgt tttaaccata 23041 tgacaacagt cgagcgcatc ataggccaaa agccgggaac aggagggtcc tcaggcgtca 23101 tgtacttacg cagagcgctc gatcaccgct ttttcccgga gctttggagc ttgcggacgt 23161 tgttgtaaaa aactcttcaa aaaaagcgag aaaagcgtct tggggaccca gggcgctttt 23221 tcgcttgtag tactcctttc acattttttc acatatctta cctaatgttg ggtataaata 23281 cccttctttt cctgacaaac atatgttttc attttttata gtatacctat tttttcaaga 23341 acaaccagaa atggagtggg catttggatg gaaacaatga agccacctat ggaagtgtta 23401 tatgcgaaac agctgaatgc gctgcgatcc catgatacag ggacaaaacc tcccaattgg 23461 ctgatgtcgc cgagagcagt gcgcgatttt attttaggaa cggatgaacc cctctcttat 23521 gagggcgaag gtatatcgat tacgaagaag ttctatggag acgaagtgct a //