LOCUS NZ_CP018145 20903 bp DNA circular CON 05-MAR-2024 DEFINITION Brevibacillus formosus strain NF2 chromosome, complete genome. ACCESSION NZ_CP018145 VERSION NZ_CP018145.1 KEYWORDS RefSeq. SOURCE Brevibacillus formosus ORGANISM Brevibacillus formosus Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus. REFERENCE 1 (bases 1 to 6437015) AUTHORS Fu,B. and Li,Z. TITLE Direct Submission JOURNAL Submitted (17-NOV-2016) Insitute of Enzyme Engineering, Shaanxi Academy of Sciences, No 16, East Renmin Road, Xi'an, Shaanxi 710600, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: HGAP v. 3 Genome Coverage :: 167.68 Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 03/05/2024 02:46:36 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.6 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,168 CDSs (total) :: 5,986 Genes (coding) :: 5,821 CDSs (with protein) :: 5,821 Genes (RNA) :: 182 rRNAs :: 16, 17, 17 (5S, 16S, 23S) complete rRNAs :: 16, 17, 17 (5S, 16S, 23S) tRNAs :: 127 ncRNAs :: 5 Pseudo Genes (total) :: 165 CDSs (without protein) :: 165 Pseudo Genes (ambiguous residues) :: 0 of 165 Pseudo Genes (frameshifted) :: 85 of 165 Pseudo Genes (incomplete) :: 95 of 165 Pseudo Genes (internal stop) :: 22 of 165 Pseudo Genes (multiple problems) :: 35 of 165 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 14:35:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 1408631 Orig. end :: 1429534 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to CP018145.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ This genome has a base modification file available. COMPLETENESS: full length. FEATURES Location/Qualifiers region 1..20903 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene-precursor" /region_number="3" /rules="(PT_FPPS_like and not PT_HPP)" /tool="antismash" cand_cluster 1..20903 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_FPPS_like and not PT_HPP)" /kind="single" /product="terpene-precursor" /protoclusters="1" /tool="antismash" protocluster 1..20903 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:10903](+)" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" /tool="antismash" proto_core 10001..10903 /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" misc_feature 72..85 /note="TFBS match to ANR, Anaerobic transcriptional regulator, confidence: weak, score: 20.06" /tool="antismash" gene 320..997 /gene="spoIIIAF" /locus_tag="BP422_RS07040" /old_locus_tag="BP422_06835" CDS 320..997 /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0003674 - molecular_function [Evidence IEA]" /GO_process="GO:0030436 - asexual sporulation [Evidence IEA]" /codon_start=1 /gene="spoIIIAF" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016739905.1" /locus_tag="BP422_RS07040" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06835" /product="stage III sporulation protein AF" /protein_id="WP_088907122.1" /transl_table=11 /translation="MTWLTLWLKKIILLVLLAAFLDLILPNTTLQRYVKMVMGLILLLT IISPVFSLFSLSQEDLAFRLDRYQQELNKPASAEWKRITDKLLGQQNQQMTAYVQSQVA SSVKASVKEQYGVTVEDVTITVNQQNPEQPTLERIELVVGDANKEEQKGQSTIEPIKPV QPVEITIGKLSEIQPDPKIEIAATAHHDNPLYAQITNGVAKEWGLSKSQVVIKDESRER EKQ" gene 1029..1724 /gene="spoIIIAG" /locus_tag="BP422_RS07045" /old_locus_tag="BP422_06840" CDS 1029..1724 /GO_function="GO:0003674 - molecular_function [Evidence IEA]" /GO_process="GO:0030436 - asexual sporulation [Evidence IEA]" /codon_start=1 /gene="spoIIIAG" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017247999.1" /locus_tag="BP422_RS07045" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06840" /product="stage III sporulation protein AG" /protein_id="WP_088907123.1" /transl_table=11 /translation="MNQLWEKLKSLFMKQQGETTQEEKKIVVGSKGKNQKLKPLHYFIV ILGIGIAIMILTDFLRVEKDQPLGFGDIGSEAPGPSGGDSTSQVLGGSPTTDVIAEYEN IYETQLRDILASVVGVGEVEVMVNLESTPELVVEKNRNIRSSTNQEMDKEKATRNQNDQ SRDEQVVIVQGGKQDAPVIVKTLKPKIRGVLVVAKGADNIQVKAWITEAVQKVLDVPAY KISILPKKG" gene 1738..2412 /locus_tag="BP422_RS07050" /old_locus_tag="BP422_06845" CDS 1738..2412 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007725717.1" /locus_tag="BP422_RS07050" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06845" /product="SpoIIIAH-like family protein" /protein_id="WP_088907124.1" /transl_table=11 /translation="MILRKQTVWLLTMLAVMVVLSGYYLVKGPQEQVPTSGQEQAVQKQ EQISGVVVESKQVDHAPKATPVDQAPKANPVDGKSGTQEEKTPAAPEAKPAATNTVVPV AETASEIFQGYKMKREAMLQQQKDEQLAIVNSTDSSPQAVAEAMAKFEELSTMESATMT AEEMLKASGYQDAVVTVQNDKATVIVQKDKLSANEVVEIIANVKQHLNIPATNINVQYK SS" gene 2621..3118 /gene="accB" /locus_tag="BP422_RS07055" /old_locus_tag="BP422_06850" CDS 2621..3118 /EC_number="6.4.1.2" /GO_component="GO:0009317 - acetyl-CoA carboxylase complex [Evidence IEA]" /GO_function="GO:0003989 - acetyl-CoA carboxylase activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="accB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012686025.1" /locus_tag="BP422_RS07055" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06850" /product="acetyl-CoA carboxylase biotin carboxyl carrier protein" /protein_id="WP_047069477.1" /transl_table=11 /translation="MKMHEIREIIKLIDQSSIQEFNLETEGAKVSLKKSNGTETIVVTQ PAVQAPVAAPVAHIPAQPVVAAAPVAAEAPKAAVQASDDANLHKIVSPMVGTFYSAPEP GKPPYVQAGDKVTASKVVCIVEAMKLFNEIEAEVSGEIVKVLVEDGQLVEYGQALFLVK PE" gene 3135..4490 /gene="accC" /locus_tag="BP422_RS07060" /old_locus_tag="BP422_06855" CDS 3135..4490 /EC_number="6.3.4.14" /GO_component="GO:0009317 - acetyl-CoA carboxylase complex [Evidence IEA]" /GO_function="GO:0003989 - acetyl-CoA carboxylase activity [Evidence IEA]" /GO_function="GO:0004075 - biotin carboxylase activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="accC" /gene_functions="biosynthetic-additional (rule-based-clusters) ATP-grasp" /gene_functions="biosynthetic-additional (rule-based-clusters) Dala_Dala_lig_C" /gene_functions="biosynthetic-additional (smcogs) SMCOG1090: acetyl-CoA carboxylase biotin carboxylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248003.1" /locus_tag="BP422_RS07060" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06855" /product="acetyl-CoA carboxylase biotin carboxylase subunit" /protein_id="WP_088907125.1" /sec_met_domain="ATP-grasp (E-value: 2e-09, bitscore: 35.7, seeds: 20, tool: rule-based-clusters)" /sec_met_domain="Dala_Dala_lig_C (E-value: 5.5e-12, bitscore: 44.0, seeds: 12, tool: rule-based-clusters)" /transl_table=11 /translation="MFQKVLIANRGEIAVRIIRACRELGIRTVAVYSEADREALHVKLA DEAYCIGPKASKESYLNIANIMSVATKVGADAIHPGYGFLAENADFAEICTACNITFIG PDPEAIVKMGDKSTAKDTMKTAGVPTVPGTEGLIEDVADAVVTANEIGYPVMVKATAGG GGRGMRVAVDDEDLEKAIRQAQNEAKTAFGNPGVYLEKFVEGPRHVEIQIMADKHGNAV YLGERDCSIQRRHQKLIEEAPSPALSEELRRQMGDAAVAAAKAVSYHGAGTVEFLLDKH GKFYFMEMNTRIQVEHPVTELVTGFDLIKEQLTVAAGQPLSFTQEDIKMDGWAIECRIN AENPAKNFMPSPGRITEYLAPGGFGVRVDSAAYAGYSIPPYYDSMIAKLIVWGKDRNEA IDRMKRALGEFVVEGITTTIPFHLKVLEHEVFVSGHFDTKFLETYDLNLDEE" gene 4560..4976 /locus_tag="BP422_RS07065" /old_locus_tag="BP422_06860" CDS 4560..4976 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005827279.1" /locus_tag="BP422_RS07065" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06860" /product="Asp23/Gls24 family envelope stress response protein" /protein_id="WP_012686027.1" /transl_table=11 /translation="MEEFTPDLDRTELGKVQIAPEVLEVIAGMAASEVEGVAQMSGGFV GEIAERLGRKNIARGVRVEVGSREAAVDVSIIVKYGHRIPEVARNIQDSVRNAIESMTG LSVVEVNVHIVDVELKAEEKVPAPVPVEEHQRVR" gene 5130..5687 /gene="amaP" /locus_tag="BP422_RS07070" /old_locus_tag="BP422_06865" CDS 5130..5687 /codon_start=1 /gene="amaP" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007785599.1" /locus_tag="BP422_RS07070" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06865" /product="alkaline shock response membrane anchor protein AmaP" /protein_id="WP_088907126.1" /transl_table=11 /translation="MNLFDRFILTIYSFALIVLSCIAIAATSGLIPQDFFRPYVDQMLA GTNITYLIVAIIFLVVSLRFFFSSFRSNKPKVERGIRQRSDLGEVNITIQTIQTIAERA ARRVKGVRDMKTTVKALESGNIITLRVSVDGETPLPELTQKLQADVKEQVEGIAGVVIS EVAIVVTEVAQQENYSSRKRVE" gene 5700..5912 /locus_tag="BP422_RS07075" /old_locus_tag="BP422_06870" CDS 5700..5912 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012686029.1" /locus_tag="BP422_RS07075" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06870" /product="DUF2273 domain-containing protein" /protein_id="WP_012686029.1" /transl_table=11 /translation="MMRELMWEHKGKLMGVFAGLFLGIIYLLVGFWDTLVFVVFVGTGY YIGRKLDHKEDLREILDKILPGKFR" gene 5959..6363 /gene="nusB" /locus_tag="BP422_RS07080" /old_locus_tag="BP422_06875" CDS 5959..6363 /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene="nusB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005827285.1" /locus_tag="BP422_RS07080" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06875" /product="transcription antitermination factor NusB" /protein_id="WP_088907127.1" /transl_table=11 /translation="MKRRTAREKVVQCLFQIDMAEVPLTDAVALVMEESEENAQYLRYL LDGVLKNLTEIDSEIKKYLRGWQLERIANVDRAILRLAFYEIMFEQDTPDKVVMNEAIE IAKLFSDEQSHRYINGVLSSFLQSRETKQA" misc_feature 5990..6005 /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 20.87" /tool="antismash" gene 6382..7341 /locus_tag="BP422_RS07085" /old_locus_tag="BP422_06880" CDS 6382..7341 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003337887.1" /locus_tag="BP422_RS07085" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06880" /product="O-sialoglycoprotein endopeptidase" /protein_id="WP_088907128.1" /transl_table=11 /translation="MSKVMLGIDTSNYRTSLCLAEEDGRIVAEAKRLLKVKEGKRGLQQ SEAVFQHVMNLPELSEEMKWKDYEIAAICVSEKPRPQDGSYMPVFKVGEGLAKSLATYL RVPLHLTTHQEGHIAAGEYTAEVRPTEDRFLAVHLSGGTSELLLCERHAAGYAIEKIGG TIDLHAGQLVDRIGVALGLSFPAGPALEQLAKGATGAFRISSAVDGLSFSFSGPEASLL REVEKGSTSPAEIARATEQCIANTLEKSLRHAVDQGYPKDILIVGGVAANYYIRERLIK RLEHPAVKAKLYFCDPVYSGDNAYGVAMLGWMKLKDEH" gene 7434..8288 /gene="folD" /locus_tag="BP422_RS07090" /old_locus_tag="BP422_06885" CDS 7434..8288 /EC_number="1.5.1.5" /EC_number="3.5.4.9" /GO_function="GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA]" /codon_start=1 /gene="folD" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248009.1" /locus_tag="BP422_RS07090" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06885" /product="bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD" /protein_id="WP_088907129.1" /transl_table=11 /translation="MAATILQGKEVAQSIRAELANEVAELKKQGIVPGLTVVIVGDDPA SHSYVRGKAKGCEEVGISSEIIMKDADITEEELLVIIQQLNENPNVNGILVQLPLPAHI SEQAVIEAIAPEKDVDGFHPISIGNMVLGNDTMLPCTPHGIIELIKRTGTPLAGKHAVV IGRSNIVGKPVSLLLQQENATVTMCHSRTQNLEEYTQKADILVVATGRAHMIGKEHVKP GAVVIDVGVNRIETGKLVGDVKFDEVKEVASFLTPVPGGVGPMTITMLLKNTVAAAKKQ AKQ" gene 8399..9781 /gene="xseA" /locus_tag="BP422_RS07095" /old_locus_tag="BP422_06890" CDS 8399..9781 /EC_number="3.1.11.6" /GO_component="GO:0009318 - exodeoxyribonuclease VII complex [Evidence IEA]" /GO_function="GO:0008855 - exodeoxyribonuclease VII activity [Evidence IEA]" /GO_process="GO:0006308 - DNA catabolic process [Evidence IEA]" /codon_start=1 /gene="xseA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016739915.1" /locus_tag="BP422_RS07095" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06890" /product="exodeoxyribonuclease VII large subunit" /protein_id="WP_088907130.1" /transl_table=11 /translation="MALQDILSVSDLNRYIKLVLEKEPHLQDIWVRGEISNFTHHSSGH MYFTLKDKQSRIKVVMFASYNRFLRFLPKDGAKAIVRGSISAYERDGAYQFYAKEMQPD GLGSLYLAFEQLKEKLAQEGLFAAERKRMLPRFPKRVGVVTSPTGAAIRDICTTIRRRY PQAEIVLSPAVVQGADAPASIVSAIRIMNDQPDIDVLIVGRGGGSIEELWAFNDENVAR AIAASLIPVISAVGHETDVTIADFVADVRAATPTAAAELAVPHYLEWVERVRQLEIRMH RAVRGTMTEQRNRLTRLSNSYAMRQPERRLEEAAERLDRAHLRMRQSMKHLLDRRRERY TRLDEQIKRYRLADQIGDKRKNLSKLRATLDERMLGRLNQKRMAFAARIATLEALSPLK VMQRGFSLVYTNDRLVKSVEQFAPGDEIMVRLSDGSATARVEKVNREEEKQSGSQENRA RD" gene 9750..10004 /gene="xseB" /locus_tag="BP422_RS07100" /old_locus_tag="BP422_06895" CDS 9750..10004 /EC_number="3.1.11.6" /GO_component="GO:0009318 - exodeoxyribonuclease VII complex [Evidence IEA]" /GO_function="GO:0008855 - exodeoxyribonuclease VII activity [Evidence IEA]" /GO_process="GO:0006308 - DNA catabolic process [Evidence IEA]" /codon_start=1 /gene="xseB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012686034.1" /locus_tag="BP422_RS07100" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06895" /product="exodeoxyribonuclease VII small subunit" /protein_id="WP_048032540.1" /transl_table=11 /translation="MARKKTEQETDMQFEDAMKRLEEVVNRLEEGDIPLEEAITLYQEG VTLSRICGQKLDAIEAKITQLVEEDGQVKQKAFRVEGES" gene 10001..10903 /locus_tag="BP422_RS07105" /old_locus_tag="BP422_06900" CDS 10001..10903 /GO_process="GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene-precursor: PT_FPPS_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182: Polyprenyl synthetase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248012.1" /locus_tag="BP422_RS07105" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06900" /product="polyprenyl synthetase family protein" /protein_id="WP_088907131.1" /sec_met_domain="PT_FPPS_like (E-value: 3.4e-62, bitscore: 208.6, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MIGVHTFESYLVEKTAYIEQRLLPALEQQGVPENLYESMKYSLMA GGKRLRPMLVLAVLEALDKPIERGVAFAAALEMIHTYSLIHDDLPAMDDDDLRRGKPTN HKVFGEATAILAGDALLTRAFAYIAEAYMDRTDVSAATTVKLIAELGKRAGATGMVGGQ MADIEGESKRLNLDQLEFIHRHKTGDLLIAALRGGGYLAEASEGQMEALTRYGVCIGLA FQIQDDILNVEGDAQELGKAVGSDADREKATYPSLLGLAESKARLEDLIAEAKVALADA GIENSALSPLADYVRDRNK" gene complement(10956..12650) /locus_tag="BP422_RS07110" /old_locus_tag="BP422_06905" CDS complement(10956..12650) /EC_number="3.4.-.-" /GO_function="GO:0004222 - metalloendopeptidase activity [Evidence IEA]" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007728774.1" /locus_tag="BP422_RS07110" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06905" /product="M3 family oligoendopeptidase" /protein_id="WP_088907132.1" /transl_table=11 /translation="MKFSQIQYERMDMDKVEGQFTQLLEAFQHAASFSEQDTIMAQLNK LRQEVESARNVAQIRHTINTEDPFYKAEQDYWDEANPLYTGIVSRYYQAIVDSSFRAEL EEKWGAQLFRIAESTLRTFSPEVISDLQEENRLASQYVALKASAKIMFDGEERNLSEMV PFTIAKDRDIRKRANEAKYDFMRQHTDEFDRIYDQLVKVRTRIAKKLGFNSFVELAYAR LNRTDYNPEMVASFRQQVLEHIVPVASKLVERQRQRIGVDTLEYYDLSFDFATGNPSPK GPPEWIVENGKKMYAELSPETDQFYNFMLDNDCLDLLSKKGKATGGYCEYISQYRLPFI FANFNGTSGDIDVLTHEAGHAFQVYVSRDFEVPEYHFPTYEACEIHSMSMEFLTWPWME HFFKEDTDKYKFSHLSSGLQFIPYGVSVDEFQHVVYENPDMTPAERKRAWREIERKYLP HRNYAQNEYLEEGGFWQQQTHIFQSPFYYIDYTLAQICAFQFWKRSQSEPKQAWEDYLT LCREGGSKSFLELVQVAKLYSPFEDDCIPSVIGEIEQFLNSIDDKSL" gene 12899..14785 /gene="dxs" /locus_tag="BP422_RS07115" /old_locus_tag="BP422_06910" CDS 12899..14785 /EC_number="2.2.1.7" /GO_component="GO:0005737 - cytoplasm [Evidence IEA]" /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate synthase activity [Evidence IEA]" /GO_process="GO:0008615 - pyridoxine biosynthetic process [Evidence IEA]" /GO_process="GO:0009228 - thiamine biosynthetic process [Evidence IEA]" /GO_process="GO:0009240 - isopentenyl diphosphate biosynthetic process [Evidence IEA]" /codon_start=1 /gene="dxs" /gene_functions="biosynthetic-additional (rule-based-clusters) DXP_synthase_N" /gene_functions="biosynthetic-additional (rule-based-clusters) TPP_enzyme_C" /gene_functions="biosynthetic-additional (smcogs) SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007728776.1" /locus_tag="BP422_RS07115" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06910" /product="1-deoxy-D-xylulose-5-phosphate synthase" /protein_id="WP_088907133.1" /sec_met_domain="DXP_synthase_N (E-value: 1.3e-125, bitscore: 416.5, seeds: 174, tool: rule-based-clusters)" /sec_met_domain="TPP_enzyme_C (E-value: 1e-07, bitscore: 30.3, seeds: 323, tool: rule-based-clusters)" /transl_table=11 /translation="MLLTTINDPQDLKKCTQPQLHTLASEIRQFLIETLSKTGGHLAPN LGVVELTLALHYVFDSPKDKLIWDVGHQAYVHKMLTGRREMFPTLRQYKGLCGFPKMVE SPHDVWETGHSSTSLSAAMGMATARDLKKEKNHVVAVIGDGALTGGMALEALNHIGHER KNVIVVLNDNEMSIAPNVGALHNYLGKIRSTENYQWAKDEVEGLLKSIPAVGGKLAHMA ERFKDSMKYLLVSGVLFEELGFTYIGPIDGHNMELLLDTLKTAKHTKGPVLIHAITKKG LGYAPAEADSVKWHGIGTYKIESGDTPKSAPTYTSVFAETMMKLADEDNSIVAVTPAMP AGSGLIPFGQKYPDRLFDVGIAEQHACTFAAGLATQGLKPVFAIYSTFLQRAYDQLIHD VARQKLHVIFAVDRAGLVGADGETHQGMYDVAFMRIIPNMVIMAPKDENELRHMMKTAV EYKGGPISYRYPRLPTRGVKMDEDLQVLPIGKAEIVREGKHVAILSFGHVFEIAEAAVK QLQEEGIKPMLVNARFCKPLDEELLLRLAKEGYDIITVEEGCEMGGFGSAVIEYYSRAG YHGMNVQVVAVPDYFVEHGSVKEQRQEVGLTADNIAARVRSLMPISKGVVEA" gene 14782..15600 /locus_tag="BP422_RS07120" /old_locus_tag="BP422_06915" CDS 14782..15600 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248015.1" /locus_tag="BP422_RS07120" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06915" /product="TlyA family RNA methyltransferase" /protein_id="WP_088907134.1" /transl_table=11 /translation="MSVRKERVDVLLVERGHYETREKAKAAVMAGLVQVAGERCDKPGT KFAEDVAITVKGEVHPYVSRGGLKLEKALRVFEIDMKDRVMMDIGASTGGFTDCALQNG ARLVYAIDVGYGQLAWSLRQDERVVVMERTNFRHMDPEAFEHERPDAASIDVSFISLRL ILPVLYRFLTGGGDVVALVKPQFEAGKDRVGKNGIVRDPDVHESVLTDIGQFASGLGFA LKGLDYSPITGGEGNIEFVMHVQKSEGGMDSEEWLQCVTEVVASAHANLK" gene 15729..16586 /locus_tag="BP422_RS07125" /old_locus_tag="BP422_06920" CDS 15729..16586 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248016.1" /locus_tag="BP422_RS07125" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06920" /product="NAD(+)/NADH kinase" /protein_id="WP_088907135.1" /transl_table=11 /translation="MKKIGIIANKGKPEARIVARELLYLLEDRGAQVFLDEHIASDVGH PELGASVEEMGKQADLVCVLGGDGTLLRIARQLAGHSIPIFGINLGTLGFLSEAEPEHL PQAVDNLLSGKYDIEKRAMLEACLVRKGITLGTYTAMNDIGIAKGSFCRIIQCAVFLDD EYVATFSGDGVIVSTPTGSTAYSLSAGGPIVAPNVDMLLLTPVAPHSLTARPMVLSGNQ TIRVEVDAIHQEMGLSIDGQFGYRLEGGDQIYIKKSPCVTPLIKWKKGGFFEAIRTKLQ GEWE" gene 16592..17041 /gene="argR" /locus_tag="BP422_RS07130" /old_locus_tag="BP422_06925" CDS 16592..17041 /codon_start=1 /gene="argR" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248017.1" /locus_tag="BP422_RS07130" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06925" /product="transcriptional regulator ArgR" /protein_id="WP_047068862.1" /transl_table=11 /translation="MNKGQRHIRIREIISNQEVETQDDLVDRLRTAGFNVTQATVSRDI KELHLVKVPLPDGRYKYSMPAEQKFNPLQKLKRMLVDSFISIDQADHFIVLKTLSGHAN AVAELIDNLPWEEIMGTISGDNTILIICRSKENTNEVTKRLMEML" gene 17058..18782 /gene="recN" /locus_tag="BP422_RS07135" /old_locus_tag="BP422_06930" CDS 17058..18782 /GO_component="GO:0005737 - cytoplasm [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0006281 - DNA repair [Evidence IEA]" /GO_process="GO:0006310 - DNA recombination [Evidence IEA]" /codon_start=1 /gene="recN" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012686041.1" /locus_tag="BP422_RS07135" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06930" /product="DNA repair protein RecN" /protein_id="WP_047068864.1" /transl_table=11 /translation="MLVELSIRNFAIIKSVTVSFQKGLNILTGETGAGKSIIIDALGLL LGGRASADFVRYGEPRAEVEGLFELPPGHPGLDVCKNVGVQIEQDGMLVVRRDISNQGK SIIRINGQLVTLAMLRELGPWLVTVHGQHDTHMLMQSDKHINWLDAYGESALGAAKQEY STLYTAYRKTKQDLERMARNDRELVQRIDLLQYQLDEIEAATLTPGEDEKLMQQRKKWM NIEKVYSTIQDAYRALHGDQKGMDWLGHAMGELERGVNYEEQLVPILEMVQSAYYQIED VVHNLRQLSYQMDFEPEQLAEVERRLDQIQSLKRKYGKSVDDILEYAATIQDELDDMHH YEDRLQQVEKQLQELAADLAVEALELSVIRSECAGKLAQEIEQQLKELHMERARFAIDV RQTPDDDGVEIDGIKRFVDANGMDQIEFLISPNPGEPLRPLAKIASGGELSRVMLAIKT ILAGTDQVETLIFDEVDTGVSGRAAQAIAEKLARVAGQRQVLCITHLPQVASMADAHFL IKKEMSENETETRVNRLSDDERVSELARMLSGAEVTAKTEEHAREMILLGRERKTVS" gene 19023..20357 /gene="spoIVB" /locus_tag="BP422_RS07140" /old_locus_tag="BP422_06935" CDS 19023..20357 /EC_number="3.4.21.116" /GO_function="GO:0008236 - serine-type peptidase activity [Evidence IEA]" /GO_process="GO:0030436 - asexual sporulation [Evidence IEA]" /codon_start=1 /gene="spoIVB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017248019.1" /locus_tag="BP422_RS07140" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="BP422_06935" /product="SpoIVB peptidase" /protein_id="WP_088907136.1" /transl_table=11 /translation="MIRQNKRKWMGSLLLLITALVVSSTPFRDLSSFPRELRLMEGSLE QLRVSVPVMGTLINSNPDILHVNGTEAREVSVDLSRPMSVEPRRAGEAQLQVKWHNIPL TAVKVNVLPDLRLYPGGQSIGVKLQTAGVLVVGHHLVDDGKNKFSPGEQAGIHVGDMII KMNDMYINDMNDVKKLINETGKKNHSVQLLVVRGKEKLSLTLHPAKDKKDSEYRMGLYI RDSAAGVGTLTFYDPNSKAYGALGHVISDVDTGQAIVVGDGQIVQASVTSIEKGQSGNP GEKFARFYNESEVLGNITKNTPFGIFGKMKDEPKRSYYQEPLPIALAEQVEEGPAKILT VVEGQKVEEFDIEIANVVKQHFPATKGMIIKVTDKRLLEKTGGIVQGMSGSPIIQKGKI VGAVTHVFVNDPTSGYGCYIEWMLQDAGVNVRDTAESRTHTTKAA" ORIGIN 1 tctccgatgc ggcagatacc gtactcaatg cctcgctcct ggtcaaaaat gccgtgggct 61 tggcgggagt tttgatcctg atcatgctat gcgcgtttcc ggctttgaag atactggtac 121 tggctctgat ctacaatctg tcatctgccg tactccaacc gcttggaaac agcccgatca 181 tcagcgcgtt aggtacgatt gggaaaagtc ttttgttcgt cttcgctgct ttggcaacgg 241 tcggcttgat gttctttctg gcgattacga tcattattgc ggcgggcaac atctccatga 301 tggttcggta ggtgatgaga tgacgtggtt aaccctgtgg ttgaaaaaaa ttatcctgct 361 cgtccttttg gctgccttcc tcgatctgat cctgcccaat acgacactgc aacgctacgt 421 aaaaatggtg atgggcttga ttctcttgct gacaatcatt tctcccgtgt tcagtctgtt 481 cagcctctcg caggaagatt tggcttttcg tctggatcga taccaacaag agctgaacaa 541 gcctgcttcg gcagagtgga aacgcatcac tgacaagctg ctcggtcaac aaaaccaaca 601 gatgaccgct tacgtccagt cacaggtagc gtcctctgta aaagccagtg tcaaagagca 661 gtacggcgta actgtcgaag atgtcacgat taccgtcaat cagcaaaatc cggaacagcc 721 cacccttgag cgaatcgagc tggtagtcgg tgacgcgaac aaggaagagc aaaaagggca 781 gagcacgatt gaaccgatta aacctgtcca gcctgttgaa attacgattg gcaaactgag 841 tgaaatacaa cctgatccca aaatagaaat tgcagcaaca gctcatcatg acaatcctct 901 ttacgcgcaa atcacaaacg gtgtcgccaa agagtggggg ctttcgaaga gtcaggtcgt 961 catcaaagac gaatcgagag aaagagagaa acagtagcgg atccagtcag tgaagcgagg 1021 tgaaaacaat gaaccaatta tgggaaaagc tgaaaagtct gttcatgaag caacaaggcg 1081 agacgacgca ggaagaaaag aaaattgtgg tagggagcaa ggggaaaaac caaaaactca 1141 agccgctgca ttatttcatc gtcatattgg gaattggcat agccatcatg attctgacgg 1201 acttcctcag agtggaaaaa gaccagccac tcggatttgg agatataggg agtgaggcgc 1261 caggtccttc tggaggcgat tcaacttccc aggtgttggg gggatcaccg actaccgatg 1321 tcattgcaga gtatgaaaac atttacgaga cgcagcttcg cgatatcctc gcttctgttg 1381 tcggcgtcgg tgaagtagag gtcatggtca atctggaatc aacaccagag ctggttgtgg 1441 aaaaaaaccg caatattcgt tcctcaacca atcaggaaat ggacaaagaa aaggcaaccc 1501 gcaatcaaaa tgaccagtca cgagatgagc aggtcgtcat cgtgcaaggc ggcaagcaag 1561 atgcccccgt tattgtgaag acgctgaagc cgaaaatccg cggggtcctg gtagtagcga 1621 aaggggccga taacatccag gttaaagcgt ggatcactga agccgttcaa aaggttttgg 1681 atgttcccgc ttataaaata tccattttgc ccaaaaaagg gtaggaggta atggcgaatg 1741 attctgcgaa agcaaacggt atggttgttg acaatgcttg ctgtcatggt tgtgctctct 1801 ggatattact tggtgaaggg gccgcaagaa caggtcccaa catcaggaca agagcaagcc 1861 gtccagaagc aagagcaaat ttctggtgtg gttgttgaat ccaagcaagt agatcacgcc 1921 ccgaaagcaa cacctgtcga tcaagctcca aaggcaaatc cggtagacgg aaaaagtggc 1981 acgcaggaag agaaaactcc tgctgcgcca gaagcgaaac cagccgcaac gaacacggtc 2041 gtcccagtag cagaaacggc gagtgaaatc ttccaaggct acaaaatgaa acgcgaagcc 2101 atgctacagc aacaaaaaga cgaacagctc gcaatcgtaa acagcacgga ttcctctccg 2161 caggcagtag cagaagcgat ggccaagttt gaagaactgt ccactatgga aagtgctaca 2221 atgactgcag aagaaatgct aaaggcgagt ggctatcagg atgcggtcgt aactgttcaa 2281 aatgacaagg cgacagtcat tgtacaaaaa gataaattga gcgcaaacga ggtcgtggaa 2341 attattgcaa acgtgaagca acacttgaat atcccagcga caaacattaa tgtacaatac 2401 aagtcatcct aatcaaaact acggtacttt ctcgttataa gggataggag aaacgggcat 2461 gatggtaagg attttctcgc ttctgttgga aaagaagcgg ggaaatcctt tcttgacgtg 2521 gtataggcaa caggctacca tggatttatg gtttgccaaa aggatacata atggactcca 2581 cgaacctcta ttgaaagaaa agaaggagtg cttgttcgta atgaaaatgc atgaaatccg 2641 cgaaatcatt aagttaattg atcaatcatc cattcaagaa tttaacttgg aaacagaagg 2701 tgccaaggtg tctctgaaaa aatccaatgg tacggaaacg attgtcgtca cgcaaccagc 2761 ggttcaagct cctgttgcag caccagtagc acatatcccg gctcagccag ttgtcgcagc 2821 agcaccggtc gcagcagaag ctccgaaagc agctgtacaa gcatcggatg acgcaaatct 2881 ccacaagatt gtatctccaa tggtagggac tttctatagc gcaccagaac caggcaagcc 2941 gccttacgta caagctggtg acaaagtgac tgcgagcaaa gtcgtttgca tcgtggaagc 3001 catgaaactc tttaacgaaa tcgaagcaga agtaagcgga gagatcgtga aagtgcttgt 3061 agaagacggc caattggttg agtatggcca agcattgttt ttggtgaagc cagaataagg 3121 tgggggagag cggaatgttt caaaaagtat tgattgccaa tcgcggggag attgccgtgc 3181 gtattatccg ggcatgccgc gagctgggca ttcgtacggt cgccgtttac tccgaagcgg 3241 atcgtgaagc gcttcatgtg aagctggccg acgaagccta ctgtattggt cccaaggcat 3301 ccaaggaaag ctatttgaat atagcaaaca tcatgagcgt agcgaccaag gtaggggcag 3361 acgctatcca tcctggttat ggcttcttgg cagaaaacgc cgactttgcc gagatttgta 3421 ccgcctgcaa cattaccttt atcggtccag acccagaagc aattgtgaag atgggggaca 3481 agtccacagc caaggatacg atgaaaacgg caggtgtccc tactgtacca ggtacggaag 3541 ggctgatcga agatgtggct gacgctgtcg tcaccgcaaa cgagattggc tatcctgtca 3601 tggtcaaagc gacagcgggt ggcggcggac gcggaatgcg cgtagctgta gacgacgagg 3661 atttggaaaa agcgatccgt caggcgcaaa acgaagcaaa aacagctttt ggcaatccag 3721 gagtttactt ggagaagttc gtggaaggcc cacgccatgt ggaaattcaa atcatggcag 3781 acaagcatgg caatgccgtt tacctgggtg agcgcgactg ctccatccaa cgtcgtcacc 3841 aaaagctgat cgaggaagca ccatctccag ccttgagtga agagctgcgc cgacaaatgg 3901 gtgatgctgc tgttgctgcg gcaaaagccg tttcctatca tggggcgggt actgtcgagt 3961 ttttgctgga caaacacgga aagttctact tcatggaaat gaatacacgt attcaggtag 4021 agcatccggt aaccgagctg gtgactggct ttgacctgat taaggagcag ctgaccgtag 4081 cggcaggcca accattgtcc tttacgcaag aggatattaa aatggatggc tgggctattg 4141 aatgccgcat taatgctgag aatcccgcga aaaacttcat gccttcgcca ggtcgtatca 4201 cggaatattt ggcgccaggc ggctttggtg tgcgcgtaga cagtgcagcg tatgcgggat 4261 attccattcc gccatactac gactctatga tcgccaagct gattgtgtgg ggcaaggatc 4321 gtaacgaagc gattgaccgt atgaagcgtg ctttgggcga attcgtcgta gagggtatta 4381 cgacaacgat tccattccat ttgaaagtat tggagcacga agtatttgtc agcggacatt 4441 tcgatacgaa attcttggaa acctacgact tgaacctgga tgaagagtaa gtagggctga 4501 tttgtaaaaa tacggtgtgc ttggtataat gaattacaaa ttagagggag gtgcgaagca 4561 tggaagagtt tactccagac ttagatagaa cagaacttgg taaggtccag atcgctcccg 4621 aagtgttgga agtgatcgcc ggcatggctg cgtccgaagt agaaggtgtg gcgcaaatga 4681 gcggcggttt cgtaggagaa atagctgaac gtttaggccg taaaaatata gcacgtggtg 4741 tgcgtgtaga ggttggctcc cgcgaagcag cggtagatgt ttcgatcatt gtcaaatacg 4801 gacatcgcat cccggaagtc gctcgaaata ttcaagatag tgtacgcaat gcaattgaga 4861 gcatgacagg tctttctgta gtggaagtaa acgtacatat cgttgatgtt gagttaaaag 4921 cagaagaaaa agtaccggca ccagtaccgg ttgaagaaca ccagcgcgtg cgctaacaag 4981 cagcggatgg atgcccccta cgaacagggg gcattttcct catttgaaaa cattgatttt 5041 gtttaggctt tgagcgtaaa ttcatggagt tttccggagc gtgccgtgtt tgtctccgtt 5101 ttcaaacatg gctgaaagga gaggtgcttg tgaacttgtt tgaccgcttt atcttgacga 5161 tttatagctt tgccctcatt gttttgtcct gcatcgcgat agcagcgacc agcggattga 5221 tcccgcaaga ttttttccgt ccatatgtgg atcagatgct ggcgggtacg aacatcacct 5281 atctcattgt cgcgattatt ttcctcgtag tcagccttcg cttctttttc agttctttcc 5341 gctctaacaa gcctaaagta gaacggggaa tccgtcagcg cagtgatttg ggtgaggtca 5401 acattacgat tcagacgatc cagaccattg cagagcgtgc agcccgccga gtgaaagggg 5461 tgcgcgatat gaaaacgaca gtcaaagcac tcgagagcgg caatattatc accctgcgtg 5521 tttcggtaga tggagaaacg ccattgcctg aactgacaca gaagctacag gctgacgtga 5581 aggagcaagt cgaggggatt gctggtgttg tcatttctga ggtggccatt gtcgtgacgg 5641 aagtagctca gcaggaaaac tactcgtctc gtaaacgtgt ggaatagaag gtgaagtaaa 5701 tgatgcggga gttaatgtgg gaacacaagg ggaagctaat gggggttttt gccggacttt 5761 ttttaggcat catctacctt ctcgtgggat tttgggatac actggttttt gttgtgtttg 5821 ttgggaccgg gtattatatt ggtcgcaagc tcgatcataa agaagacttg cgtgaaatac 5881 tcgacaagat tttgccaggc aagtttcggt gacgtaagaa aagtccgagc tcattttaat 5941 tagtaggtga atgaatgtat gaaacgaaga acagcacgag aaaaagtagt ccaatgtctt 6001 ttccaaatcg atatggcaga ggttccatta accgatgcgg ttgccctcgt catggaagaa 6061 tccgaggaaa atgcacagta tttgcgttat ctcctcgatg gtgtgttgaa aaacttgact 6121 gagattgatt cagaaatcaa gaagtatctg cgtggatggc aattggaacg catcgccaat 6181 gtagatcgcg ctattcttcg tctggctttt tacgagatca tgttcgagca ggacacacct 6241 gacaaagtcg tgatgaacga agcgattgag atcgcgaagc tctttagcga cgaacagtcc 6301 caccgataca taaacggtgt gttgtcgagc ttcttgcaat cacgtgaaac caagcaggcg 6361 taataggtag gagatacaag catgagtaag gtaatgttgg gaatcgacac gagcaattac 6421 cggacatcac tgtgcttggc tgaggaagac ggccgaattg tcgcagaagc aaaacgcctt 6481 ctgaaagtaa aagagggcaa gcgcggactg caacaatccg aagccgtctt tcagcatgtg 6541 atgaacctgc cggaattaag tgaagagatg aagtggaagg actacgagat tgcagcgatt 6601 tgtgtgagcg agaaaccgcg tccgcaagac ggatcgtata tgcctgtatt taaggtagga 6661 gagggcttgg cgaaatcgtt ggcgacttat ttgcgggttc ccctgcactt gacgactcat 6721 caagaggggc atatcgcggc gggggaatac accgctgagg tgcgcccgac tgaggaccgc 6781 tttttggctg tgcatttgtc tggagggacc agcgagttgc tgctgtgtga gcgtcatgca 6841 gctgggtatg ccattgagaa aatcggtggg acgattgatc tgcacgcagg tcaactagtc 6901 gatcggattg gtgtggcact cggtctgtcc tttccggcgg gtcctgcgtt ggagcagtta 6961 gcaaagggag caacaggtgc gtttcggatt tcttcggcgg ttgacgggct ttcctttagt 7021 ttttctggtc cagaagcatc acttttgcgg gaagtggaga aggggagtac gagccctgct 7081 gaaattgcgc gggcgacaga gcaatgcatt gccaatacac tagagaagtc attgcgccat 7141 gcagtagacc aaggctaccc gaaggacatc ttgattgttg gaggagtagc tgccaattat 7201 tacatacgtg agcggctgat caaacgtctg gaacaccctg ccgtgaaggc gaagctgtac 7261 ttctgtgacc ccgtttactc cggcgataat gcctacggag tcgctatgtt ggggtggatg 7321 aagctaaaag acgaacatta aataaatgcg aactttttat aattcgcctt tacagttgag 7381 ggggaaatcg gtacacttaa cgtatcgacg taaataaagg aggcattttc tccatggctg 7441 caaccattct ccagggaaaa gaagtagcac agagtattcg ggccgaattg gcgaacgaag 7501 tagctgaatt gaaaaaacaa gggatcgtac cgggtttgac cgttgtcatt gtgggagacg 7561 acccagcttc tcactcctat gtacggggga aagcaaaagg ctgcgaggaa gtcggaattt 7621 catccgagat cattatgaag gacgctgaca tcacagagga agagttgttg gttatcattc 7681 aacagttgaa cgaaaatccg aacgttaatg ggattttggt tcagcttcct cttcctgctc 7741 atatttcaga gcaagcggta attgaagcca ttgctcctga aaaagatgtg gacggtttcc 7801 atccgattag cataggtaac atggtactgg gaaatgatac gatgcttcct tgcacgccgc 7861 atgggattat tgaattgatc aagcgcacag gcacaccatt ggcaggcaaa catgcagtgg 7921 tgatcggacg cagcaacatc gttggaaagc cggtctcatt gctgttgcaa caggaaaatg 7981 ctacggtaac catgtgtcat tctcgcacgc aaaatctcga ggaatacact caaaaggcgg 8041 acatcctggt cgttgcaacc ggtagggctc atatgattgg caaggagcat gtcaaaccgg 8101 gcgctgtcgt cattgacgtt ggagtgaacc gcatcgaaac gggtaagctg gttggagatg 8161 tcaagttcga cgaggtcaaa gaagtggcta gctttttaac cccagttcca ggcggtgttg 8221 gcccgatgac gattaccatg ctgttgaaaa ataccgttgc ggcagcgaaa aagcaagcaa 8281 aacaatagaa gaatatcggc aacttattat agaatggata aggcataagc tttatccatt 8341 cttttgcata gtccttgtta catgcacggc aaagccagtt tttgtaaagg agggccgcat 8401 ggcattacaa gatatcttat ctgtcagtga tctcaatcgt tatattaagc tggtgctgga 8461 aaaggaaccc cacctgcaag atatatgggt gagaggggaa atctccaatt ttacccacca 8521 ctccagcggt catatgtatt tcacgctaaa ggacaagcaa tcacgcatca aagtcgtcat 8581 gtttgcgagt tataatcgct tcctgcgttt cttgcccaaa gatggagcaa aagcgattgt 8641 gcgcgggtct atttctgcat acgaacggga cggggcgtat cagttctacg ccaaagagat 8701 gcagccagat ggtctcggat cgctttattt agcatttgag cagctaaaag aaaaattggc 8761 tcaagaaggg ttgtttgcag cagagagaaa gcggatgctc ccgcgttttc ccaaacgtgt 8821 cggtgtcgtc acctctccga caggagctgc catccgagat atttgtacga cgattcgcag 8881 gcgatatccg caggcagaaa tcgtactttc accagccgtt gttcaaggtg cggatgcacc 8941 tgcatcgatt gtctccgcta ttcggatcat gaacgatcag cctgacattg atgttcttat 9001 tgtagggcgc ggtggtggtt ccatcgaaga gctgtgggcg tttaatgatg aaaacgtcgc 9061 gagggcaatt gctgcatcac tcatccccgt catctccgct gtaggacacg agacggatgt 9121 gacgatcgcc gatttcgtag cagatgtccg ggcagctacg ccgaccgccg cagctgaatt 9181 ggctgtaccg cattatttgg aatgggtcga gagggtgcgg cagctagaaa tacggatgca 9241 tcgagcagtg cgtggcacga tgacagagca gagaaaccgt ttgacacgct taagcaattc 9301 gtatgcgatg cgccaaccgg agcggaggct ggaggaagcc gcagaacgat tggatcgggc 9361 gcatttacgg atgcgccaat cgatgaagca tttgctggac agaagacgcg aacgctatac 9421 gcgattagac gaacagatca agcgctatcg cctcgctgat caaattgggg ataaaagaaa 9481 aaatctgtct aaactccgcg ccaccttgga cgaacggatg ctggggcgtc tcaatcaaaa 9541 aagaatggca ttcgcagccc gcatagctac attggaagca ctgagtccac tgaaggtcat 9601 gcagcgtgga ttctcactcg tatacaccaa tgacagactc gtgaaatcgg tggaacagtt 9661 tgcccctggc gacgagatca tggtacgatt aagtgatggc agtgcgactg cgcgtgtgga 9721 aaaagtgaac cgggaggagg agaagcagag tggctcgcaa gaaaacagag caagagactg 9781 atatgcagtt cgaggacgcg atgaagcgcc tagaagaagt cgtcaatcga ctcgaggaag 9841 gagatattcc actcgaagaa gcgattacgt tatatcagga aggagtaact ctttccagaa 9901 tttgtggtca aaagctggat gcaatcgaag cgaagattac ccagttggtg gaagaagacg 9961 gacaagtaaa gcagaaggct tttcgagtgg aaggagaatc atgatcggcg tgcatacatt 10021 cgagagttat ttggtagaga agaccgccta tatagaacaa agactcctgc cagcccttga 10081 gcagcaagga gttccggaaa acttgtacga atccatgaag tattcgctca tggctggcgg 10141 aaagaggctg cgtcccatgt tggtattggc ggtcctcgaa gcgctggaca agccgattga 10201 acggggtgtg gcatttgcgg ctgccttgga aatgatacat acgtactcct tgattcacga 10261 tgacctccca gcgatggacg acgatgatct tcgtcgcgga aaaccgacca atcacaaagt 10321 attcggtgaa gcaacagcga ttctcgcagg agatgccttg ctgacaagag cgttcgcata 10381 cattgcagaa gcttacatgg atcgcaccga tgtttcggcg gctactaccg tgaaactgat 10441 tgcggaactg ggaaaacgtg caggagcaac tggcatggtc ggcggacaga tggctgatat 10501 cgaaggggag agcaagcgcc ttaacctgga tcaactcgaa tttatccatc gtcacaaaac 10561 gggtgatctc ttgatcgcag ccttgcgcgg gggaggctac ctcgcagaag catccgaagg 10621 ccaaatggaa gcattgacac gctatggtgt ttgtattggg cttgcttttc aaattcagga 10681 tgacatcttg aatgtggaag gggatgccca agagctgggg aaagcagttg gcagcgatgc 10741 ggatcgggaa aaggcgacgt acccatcgct tcttggtcta gccgaatcga aggcgcgtct 10801 tgaggatttg attgcggagg caaaagttgc gcttgcagat gcgggaatcg agaactctgc 10861 actcagccct ttggcggact acgtgcgtga tcgcaataaa taagggaagc tggcaaccca 10921 tacgggtaat gccagctttt ttgtatacct acctatcaca agcttttatc gtcaatgcta 10981 tttaagaatt gttcaatctc gccaatcacc gatggaatgc agtcgtcctc aaatggagaa 11041 taaagcttcg ccacttgcac cagctcaagg aacgatttgc ttccgccttc gcgacaaagc 11101 gtcaaataat cctcccaagc ttgtttgggc tctgattgag atcgtttcca aaattggaac 11161 gcacaaatct gggccagtgt gtagtcgatg taatagaagg gactttgaaa aatatgcgtt 11221 tgctgctgcc agaacccgcc ctcttcaaga tactcattct gtgcgtaatt gcgatggggg 11281 aggtacttgc gctcaatttc acgccaagcc cgtttacgct ctgccggggt catatctggg 11341 ttctcgtaga cgacatgctg gaactcatcc acagacacac catacggaat gaattggagt 11401 ccgctactca aatgagagaa tttgtatttg tcggtatctt ccttgaaaaa atgctccatc 11461 catggccacg tcaaaaactc catgctcatc gaatgtattt cacatgcctc ataggttggg 11521 aaatgatatt caggcacctc aaaatctcgg cttacataca cctgaaacgc atgtcctgcc 11581 tcgtgcgtaa gtacgtcgat atcaccggat gtaccattaa aattggcgaa aataaagggg 11641 agtctgtatt ggctgatgta ttcacagtag cctcccgtag ccttcccttt tttgctcaag 11701 agatccaaac agtcgttgtc cagcatgaag ttgtaaaatt ggtccgtttc aggtgacaac 11761 tctgcataca tctttttccc gttttccaca atccattccg gcgggccttt cgggcttgga 11821 ttccctgtag caaaatcaaa ggaaagatcg taatactcaa gtgtatcgac accaatgcgc 11881 tgtcgctgac gttcaaccag ctttgacgct acgggaacga tgtgctcaag cacttgctgt 11941 cggaaactgg ctaccatttc cggattgtaa tcggtacggt tcaaacgtgc ataggctaac 12001 tccacaaagc tattgaagcc gagttttttg gcgatgcgtg tacgtacctt gacgagctga 12061 tcgtagatgc gatcaaattc gtccgtgtgt tgccgcataa aatcatactt cgcttcatta 12121 gcgcgtttgc ggatgtctct atctttcgca attgtaaaag gaaccatctc tgaaaggttt 12181 cgttcttctc cgtcaaacat gattttggcc gaagctttca gtgcgacata ttgactcgcc 12241 aaacggtttt cttcctgcaa atcagaaata acctctggag aaaatgtacg gagtgtgctc 12301 tccgcgatgc gaaacagctg tgctccccat ttttcctcca attcagcgcg gaaggaagaa 12361 tcgacaatcg cctgatagta gcgggaaacg attccggtat acaaaggatt tgcttcatcc 12421 caatagtcct gctccgcttt gtagaaagga tcttctgtat tgatcgtatg gcggatttgt 12481 gcgacattcc gcgcagactc cacttcttgt cgcagtttgt tcaattgagc catgatcgta 12541 tcttgctcgg agaagcttgc agcatgttga aacgcttcca acagttgcgt gaattgtcct 12601 tcaactttgt ccatatccat gcgctcatac tgaatttgtg agaacttcac ggatgtccac 12661 ctcttttgtt cggagtatgt attcaaaacc atcttaccag aaaatgcaag atatcgcctt 12721 catattcgta tatgttgatc aaaagtggtg tttttattaa gaaaccgtta taatgaatca 12781 agctgaaaat aagcggaatc ggctatagca ataaggaaag ccgggttttc tagtggcttg 12841 attgatatgc agcatgcaca atcgccggag aacgaacagt ggaaagtgag gaataccaat 12901 gctgcttact actataaatg atcctcaaga cttgaaaaag tgcacgcaac cgcagttaca 12961 tacattggca tccgagatcc gtcagtttct aatcgaaacg ctctcgaaaa caggcggaca 13021 tctcgcgccg aatctgggag ttgtcgagct gacgctagcg ctgcactatg tttttgacag 13081 tcccaaggac aagctgatct gggatgttgg acatcaagca tacgtacata aaatgttgac 13141 aggacgccgg gagatgtttc cgaccttgcg tcagtacaaa ggtctgtgtg ggtttccaaa 13201 aatggtggaa agcccgcatg acgtatggga aaccgggcat agcagcacgt cgttgtctgc 13261 cgcaatgggc atggcgactg cgcgggattt gaaaaaagaa aagaaccatg tcgttgcagt 13321 gatcggagac ggtgcgctga caggcggtat ggctttagag gccttgaacc acattggtca 13381 tgagcgcaag aatgtcatcg ttgtgctaaa tgataacgag atgtctattg cgccaaacgt 13441 tggtgccttg cacaactact tggggaaaat tcgctcgacg gagaactatc agtgggcgaa 13501 ggatgaagtc gaaggcttgt tgaaatcgat accggctgta gggggcaaat tagctcacat 13561 ggctgaacgc tttaaggata gcatgaagta tttgctcgta tctggcgttc tcttcgagga 13621 gctaggcttt acgtatattg gcccaatcga cggacataac atggagcttt tgctcgatac 13681 attgaagacg gccaagcata caaaaggacc tgtattgatc catgctatca cgaaaaaagg 13741 actgggctat gcgccagcag aagctgactc ggtcaagtgg cacggtatcg gtacgtataa 13801 aatcgagtca ggtgatacac cgaaatctgc cccaacgtat acatctgttt ttgcggaaac 13861 gatgatgaag cttgcagatg aagacaattc aattgtggct gtgacccctg cgatgccggc 13921 gggttccggc ttgatcccat tcggtcagaa gtacccggac agactttttg acgtcgggat 13981 tgcagagcag cacgcatgta catttgcggc aggattagcg acacaaggct tgaagccggt 14041 ctttgcgatt tattcgacct ttttgcaaag agcctatgat cagttgatcc acgatgtcgc 14101 acgccaaaag ctccatgtga tttttgccgt tgaccgtgct ggactcgtcg gagcagacgg 14161 agagacacat caaggcatgt acgatgtggc attcatgcgc atcattccga atatggtcat 14221 tatggcaccg aaggatgaaa atgagctgcg tcacatgatg aagacagcag tggaatataa 14281 aggcggtccg atctcttatc gttatccgcg attgccgact cgtggcgtca aaatggatga 14341 agatctacaa gtgctgccaa tcggaaaagc ggagattgta cgcgaaggca aacacgtggc 14401 gattctctcg tttggtcacg tattcgaaat tgctgaggcg gctgttaagc agcttcaaga 14461 agaaggaatc aaaccgatgc tggtcaatgc acgtttttgc aagccgttgg acgaagagct 14521 tctattgcgt ctggcaaagg aaggctacga tatcattaca gttgaagaag gctgtgaaat 14581 gggcggcttc ggcagcgctg tcattgaata ctacagtcgt gcgggctatc acggcatgaa 14641 tgtacaagtt gtcgcggtac ctgattattt tgttgagcat ggaagtgtga aagaacagcg 14701 gcaagaggta ggtctcacag ctgataatat cgctgctcgt gtccgatcct tgatgccaat 14761 ttcgaagggc gtagtggaag catgagtgta agaaaagaac gggttgatgt tctcttggtc 14821 gaaagaggcc attatgagac cagagaaaaa gcaaaagcag ccgtaatggc aggccttgtg 14881 caagtagctg gcgagcgctg tgacaagccg ggaaccaaat ttgccgagga tgttgcgatt 14941 acggtgaagg gcgaggtaca cccgtatgtg agtcggggtg gcctcaagct ggaaaaggca 15001 ctgcgtgtct ttgaaatcga catgaaggat cgtgtcatga tggacatcgg ggcctccact 15061 ggtggattta cggattgtgc gctgcaaaac ggtgcgcgcc ttgtatacgc cattgatgtc 15121 gggtacggac aactcgcgtg gagcttgcga caagatgaac gagtggtcgt catggaacgg 15181 acgaatttcc gtcatatgga cccggaagcg tttgaacatg aacgcccaga cgcggcatcg 15241 attgacgtat cgtttatttc gttgcgattg atcttgccag tgttgtaccg ttttctgacg 15301 ggtggcggtg acgtcgttgc gctggtcaag cctcaatttg aagcaggcaa ggatagagtc 15361 ggaaagaatg gaatcgttcg tgatccagac gtacacgaga gcgtactgac tgacatcggt 15421 caatttgcca gtggattggg tttcgcgcta aagggcttgg actactctcc aattacgggg 15481 ggagaaggaa acattgaatt tgttatgcat gtccagaaaa gtgagggcgg catggattcg 15541 gaagagtggt tgcaatgcgt aacagaggta gttgcgtctg ctcatgcaaa tttgaaatag 15601 gataaaatac caaagcctcg ggagttttgt cacaatcgag gctttttatt tatgcatgtg 15661 aagttgtata cttgtatatg aggttgttca agaaggattt ccaaccaacc agttttgggg 15721 tggaccacgt gaagaaaatt ggaatcatag cgaacaaagg aaaacccgaa gcacgtatcg 15781 ttgcacggga gctgctgtat ttacttgagg acagaggggc gcaagtattc ctggatgaac 15841 atatcgcatc agatgtaggg catccagaac tgggcgcatc tgtagaagag atggggaagc 15901 aggcggattt ggtttgtgta ttgggaggcg atggcacgct actcagaatt gctcgtcagc 15961 ttgccggtca ctctatcccg atctttggaa ttaatttagg cacgttgggc tttttgtcgg 16021 aagcggaacc ggagcatctg cctcaggctg tagataatct cctttctgga aagtacgaca 16081 ttgaaaagag agccatgctg gaagcttgtt tggtgcgaaa aggaatcaca ctggggacat 16141 acacggccat gaatgatata gggattgcca aagggtcatt ttgccgaatc attcaatgtg 16201 cggtctttct cgatgatgag tacgtcgcaa cgttcagcgg agatggtgtc attgtctcta 16261 cgccgacagg atcaacggct tactcactct cggcaggcgg tcctatagtg gcgcctaatg 16321 tggacatgct attactgaca ccagtggctc ctcattcctt gacggctcgg ccaatggtat 16381 tgtcaggcaa tcaaacgatc cgggtcgaag tggatgctat acatcaagag atgggactgt 16441 ctattgacgg gcagtttggt tatcgactcg agggcggcga tcaaatttac attaaaaagt 16501 caccgtgtgt taccccgctg attaagtgga aaaaaggtgg ctttttcgaa gcaatacgaa 16561 cgaaattaca aggggaatgg gagtaatcca tatgaataaa gggcaacgac atattcgtat 16621 tcgggagatc atcagcaatc aagaggtgga aacccaggat gatctggtgg accgcttgcg 16681 gactgctggc tttaacgtga cgcaagcgac tgtatcccga gacatcaagg agctacactt 16741 ggtaaaagtg ccacttcccg atggacgata taagtattca atgcctgctg aacaaaaatt 16801 caatccactg caaaagctga aacgcatgct tgtggattcc tttattagca ttgaccaagc 16861 tgatcatttt attgtactga agactctttc gggacatgcg aatgcggtag ctgaactgat 16921 tgacaacctt ccatgggaag aaatcatggg gacaatcagt ggcgacaaca ccatcctgat 16981 tatttgccgc tccaaagaaa ataccaatga agtgacaaaa cgcttaatgg aaatgttgta 17041 gaaggtggtc gcttgcgatg ctagtggaac tctcaatccg aaattttgcc atcatcaaat 17101 cagtgacggt ctcatttcaa aaaggcttaa acatcctgac tggggagact ggtgccggta 17161 aatccatcat tatcgatgcg ctaggactgt tgttaggggg ccgggcttcg gctgattttg 17221 tccgttacgg tgagcctcgt gcagaagtgg aagggctgtt tgaattgccg cctggtcacc 17281 ccggacttga cgtttgtaag aatgtcggcg tccagattga gcaagacggt atgcttgtgg 17341 tacgccgaga tatatcgaat caagggaaga gtatcattcg aatcaatggc cagctcgtaa 17401 ctctcgcgat gctgcgtgag ttagggccgt ggctggttac ggtgcatgga caacacgata 17461 cgcatatgct gatgcagtca gacaagcata tcaattggct cgatgcatac ggggaaagtg 17521 cgttgggagc tgcgaagcaa gagtacagta ccctgtatac tgcgtaccgt aaaacaaagc 17581 aagatctgga gcgcatggca cgaaatgatc gggagctggt gcagcgtatc gatctattgc 17641 aatatcaact cgatgaaatt gaggcggcaa ccctcacgcc tggtgaagac gagaagctca 17701 tgcagcagcg gaaaaagtgg atgaacattg aaaaagttta ttcaacgatt caagatgcat 17761 accgcgcatt gcatggtgac cagaagggca tggattggtt aggacatgcg atgggcgagc 17821 ttgagcgtgg tgtgaactac gaagaacagc tcgttccgat tttggagatg gtccaatcgg 17881 cctattatca gatagaagat gtggttcata acctacgtca attgtcgtac caaatggatt 17941 ttgaaccgga gcagctggca gaagtagaac gtcgccttga tcaaatccag tcgttaaaac 18001 gcaagtatgg caaaagtgta gacgatattt tggagtacgc agccacgatt caggatgaat 18061 tggatgacat gcatcactac gaagatcgcc ttcagcaggt ggaaaagcaa ttgcaggagc 18121 ttgcagccga tttagcagtg gaggcattgg agttatcggt tattcgttcc gaatgtgcag 18181 gaaaactcgc acaagaaatc gagcagcagc taaaagaact gcacatggag cgtgctcgtt 18241 ttgccatcga cgtcagacag acaccggatg atgacggggt agaaatcgac ggaatcaagc 18301 gcttcgtaga cgcgaacgga atggatcaga tcgagttttt aatctcacct aaccccggtg 18361 aaccattgcg tcccttggcg aagattgctt ctgggggaga gctgtctcgt gtcatgctgg 18421 ccattaaaac gattttggcg ggcactgatc aagtggagac cctcattttt gatgaagtcg 18481 acacgggtgt aagcggaaga gccgctcaag cgatagcaga aaagctcgcc cgggtcgctg 18541 ggcagcgcca ggtcctgtgc atcacgcact tgccacaggt cgcatccatg gcagacgcgc 18601 attttctgat caaaaaggaa atgagcgaga atgaaacaga gacgcgggtg aatcgtttgt 18661 ctgatgatga acgggtatca gagctggctc gcatgctaag cggggcagag gtaactgcga 18721 aaacagaaga acatgcacgc gagatgatcc ttctcggccg tgaacgaaag actgtcagct 18781 aatttggttg gcagtctttt tttattgtag gtagtacaac gattggtctc gccaagggct 18841 tgtgaagcct ggttttctaa tgttttgagt gggttatttt cctgacataa tccgcttggc 18901 tggtggcaac attaaaggta cacaaggtgg aggtgtccct catgaccgct tgcggtcaat 18961 caaaacggaa ctgaccgttt tgttttgtag gtgtaggtag ggaacggtag gagtgattac 19021 tggtgatccg acaaaacaaa agaaaatgga tgggaagtct ccttctcctc atcacggcgc 19081 ttgtcgtgag ttccaccccg ttccgcgatc tgtcctcctt tccccgtgaa ttgcgtttga 19141 tggaagggtc cctcgagcaa ctacgggtct ctgtgccggt aatgggcacg ctaatcaata 19201 gcaatcctga tattttgcac gttaacggga cagaggcgcg tgaagtatcc gttgatttga 19261 gcaggcctat gtctgtagag ccgcgtaggg ctggggaagc ccaattgcag gtgaagtggc 19321 ataacattcc gctgactgct gtaaaagtaa atgtattgcc agatctgcgg ttgtaccctg 19381 gtggacagtc aatcggggtg aagctgcaaa cagcgggtgt tttggttgtc ggtcatcatt 19441 tagtagacga tgggaaaaac aagttttctc caggtgaaca ggcaggtata cacgtcggtg 19501 acatgattat caaaatgaac gacatgtaca tcaacgacat gaacgatgtt aagaaattaa 19561 ttaacgaaac ggggaaaaag aatcattccg ttcaattgct tgtcgttcgt ggcaaggaaa 19621 agctatcgct cactttgcac ccggcaaaag ataaaaaaga cagtgaatac cgtatgggtc 19681 tctatattcg ggattcagcg gcaggagtag ggacactgac cttttatgat ccaaattcca 19741 aagcgtacgg ggcattaggg cacgtcattt ccgacgttga tactggccaa gccattgtcg 19801 taggagatgg ccagatcgtg caagcaagtg tcacatcgat tgaaaaagga caaagtggca 19861 acccagggga gaaatttgcg cgtttctaca atgaaagtga agttcttgga aatataacca 19921 aaaacacccc ttttggcatt ttcggcaaaa tgaaggacga gcccaaacgc agctattatc 19981 aggagccgtt accaattgct cttgctgagc aggtagagga agggccagcc aaaatcctta 20041 ctgtcgtgga aggtcagaag gtagaagagt tcgatattga gatcgcaaac gtggtcaagc 20101 agcattttcc tgcaaccaaa gggatgatta ttaaagtcac ggacaaacgc cttttggaaa 20161 agacaggtgg catcgtacaa gggatgagcg gcagtcctat cattcaaaaa ggcaagatcg 20221 tcggtgccgt cacccatgtg tttgttaatg atcctacttc gggatacggc tgctacattg 20281 aatggatgct tcaggatgct ggcgtgaatg tccgagatac tgccgaatcc cgaacccata 20341 caaccaaggc tgcctgaagg aagtgccgtc acgcaaacga agcgaggcgg cttttccgat 20401 ttttgcattc ctttggagaa tcggttcgga atgaaaggaa tctttgtcga aatatcagtt 20461 aaatcattca atctttcgtc attggcagga atggaatttg ctttgtcgaa taatttttgt 20521 agagaaaaag atggtatgga ctaacccttt tagatttgtt acttctagaa cgccaccttc 20581 tttccaaaag aacgtccatt gttaggagga acgaccttga gcaagattga agtgttgttg 20641 gcagatgata accgagaatt tgtgaatctg ttagaagagt acatcagtag ccagtatgac 20701 atgaatgttg tgggtgttgc ttacaacggt aatgaggtag ttcgactgct gcaggaacgt 20761 gtacccgatg tattaatttt ggatatcatc atgccacatc tggatggctt ggctgttttg 20821 gagcaaattc aggccatgcg cttaagtcct caacctaaaa ttatcatgtt gactgctttc 20881 gggcaggaag agattacaaa gaa //