LOCUS       NZ_CP022161            10471 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9646745
            Orig. end                         :: 9657216
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10471
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="43"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10471
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10471
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5471](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5471)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            876..1415
                     /locus_tag="CES90_RS43370"
     CDS             876..1415
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018839044.1"
                     /locus_tag="CES90_RS43370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_189788508.1"
                     /transl_table=11
                     /translation="MDTMNPAEDYSPSCRDLVGLLAQTDRRAAYAALALGATSVAEVAE
                     LTKLRPPAAAAALQKLTDGRIAAFDSEKRTYTLLDDTFRLAVQAEVSVSGRGSGDGAGS
                     YFRRGRLTSIPGKAEVRSRVLAVVKDSFEPGVTYSEAKVNAICGEWFDDWVSLRRALVD
                     EGLLRRNESGTTYERV"
     gene            complement(1495..1878)
                     /locus_tag="CES90_RS43375"
     CDS             complement(1495..1878)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040041.4"
                     /locus_tag="CES90_RS43375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6262 family protein"
                     /protein_id="WP_189788509.1"
                     /transl_table=11
                     /translation="MLRRGFGLRPPRRRSRRARTNAEKAISAAQRTGSHTSFAAIAKEA
                     GVSRSWLYTQQDLLTAIRQLQNRRPSSQRTGLQPASATSIQRRLEIALTRINHLRAENS
                     ELTRRLETAYGEVRRLRSERPLP"
     gene            complement(2241..3074)
                     /locus_tag="CES90_RS43380"
     CDS             complement(2241..3074)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974487.1"
                     /locus_tag="CES90_RS43380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YhjD/YihY/BrkB family envelope integrity protein"
                     /protein_id="WP_189788510.1"
                     /transl_table=11
                     /translation="MPMKPSGAADRSSRFGPLHRLISHSPVGRGWRRSREIELWSRSLG
                     FAALGLLTLVPLLIIVSSADPEHGRGFAQWLGEGLGVSTASMRQVEQLFTGPGQALRTT
                     TAFGIAALAVFGLTFGAAVQTGYEKVWGLSPARWWARWRHVMWLGVLTGYLYVSATTAL
                     RREPLAGGAVVSLSAVLLLWWSQRLLLGGRIRWRALFPGAVATVIGLLGLRVFSRLVFS
                     PLIASNTVTYGPMGTVLVIQSWLVGVGIVVFGGALVGRLLHEELPRMAHARKRRR"
     gene            3234..3590
                     /locus_tag="CES90_RS43385"
     CDS             3234..3590
                     /GO_function="GO:0042314 - bacteriochlorophyll binding
                     [Evidence IEA]"
                     /GO_process="GO:0019684 - photosynthesis, light reaction
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486008.1"
                     /locus_tag="CES90_RS43385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PRC-barrel domain-containing protein"
                     /protein_id="WP_189788511.1"
                     /transl_table=11
                     /translation="MIHSADIREWRNRSVVDPKGHKIGVLEAVYVDTTTDEPAMATVRT
                     GLPIRHHLAFVPLDEATLGPDYVKVSYTKTLVKKAPWVGMDDILPAESEEAIFQHYDMP
                     YQTGAGGERQLARR"
     gene            3627..3797
                     /locus_tag="CES90_RS43390"
     CDS             3627..3797
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049997.1"
                     /locus_tag="CES90_RS43390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189788512.1"
                     /transl_table=11
                     /translation="MALLLFLVLLAVVLGIIGVAAEGVGYLLIIGIVILVAALGLIAVR
                     WSQRTGRRPLR"
     tRNA            3964..4044
                     /anticodon=(pos:9650747..9650749,aa:Gly,seq:tcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CES90_RS43395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gly"
     gene            3964..4044
                     /locus_tag="CES90_RS43395"
     gene            complement(4151..5017)
                     /locus_tag="CES90_RS43400"
     CDS             complement(4151..5017)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="CES90_RS43400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_189788513.1"
                     /transl_table=11
                     /translation="MVYTRKDVSALTRSERHRFVNALLEVKRRGEYDEFVRTHIEYYRS
                     DGEAGLRVAHMAPTFLPWHRKFLLDLEEALRRVDDRVTVPYWDWTRNRGTTAVPWTADL
                     LGGTGRRSDRQVMTGPFAYRNGQWTIEVGITDTEFLTRDLGRSRDPIALPRAGDLERAL
                     ADPVYDAAPWNSTSAKGFRNRLEGWGSGRGVVSWLTHNRVHRWVGGHMVGGASVNDPVF
                     WMHHAFVDLLWSRWQRRHPNARYLPAEQPALGSGQRGRVVARHEPMPPWDVTPDSLEDL
                     SGIYRYA"
     gene            complement(5001..5471)
                     /locus_tag="CES90_RS43405"
     CDS             complement(5001..5471)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028525.1"
                     /locus_tag="CES90_RS43405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_373313637.1"
                     /sec_met_domain="melC (E-value: 2.1e-45, bitscore: 153.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATSRFFGNGETTGRRRVLRGAFVAALGITPAPFLVASRSAGTEE
                     TRFDETYRGRRIVGVRHEDGPSGGGTPGTWHVTVDGRPLHLMRRADGSWMSMIDHYQSY
                     ETPLAAARAAVDELGPTARLGAPGDRSSRTDGSRTPSGCEGAERDHRRGVHA"
     gene            complement(5669..5911)
                     /locus_tag="CES90_RS43410"
     CDS             complement(5669..5911)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529518.1"
                     /locus_tag="CES90_RS43410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189788514.1"
                     /transl_table=11
                     /translation="MKSLKAAAIVAGSLVVAGFATPALALDAPGSQSGGLGQAVTGITD
                     GVQLNGKKVLDPRQGLAGTLQGATGGLGNGGKLAG"
     gene            complement(6183..6863)
                     /locus_tag="CES90_RS43415"
     CDS             complement(6183..6863)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS43415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189788515.1"
                     /transl_table=11
                     /translation="MRTFTARRIATSALCATFLIGVTAPTALAADTARDRTRESAPVSE
                     AETLQGQVAHLGSIGIVVPPVTTLMDTVLKAPNHRLSEADAQRLGDAAKAAIAKVAATA
                     VTPANPANPANPANPANPATPGMTTPAAPTVPNVSANPAFVPQLAENEARDETAPADTL
                     TDAIAELQKAVDQLVTAAKTGDVSGALSAVTGVSTKLASVVVALLLGAVPSLPGLPVPL
                     EQPS"
     gene            7358..8671
                     /locus_tag="CES90_RS43420"
     CDS             7358..8671
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613024.1"
                     /locus_tag="CES90_RS43420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_189788528.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-32,
                     bitscore: 112.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSRPIGSSRSGTRRGTAPRVLHVTQPVDGGVTHVVTELVRAQRA
                     DGFDVTVACPDSHFARTMRELGADVRPWHATRAPGRSLPDEVRRLARVIDEVRPEVLHA
                     HSAKAGLAARLAVRGRIPTVFQPHAWSFEAVGGVTAVAATAWERWAARWTARVVCVSEA
                     EHARGVRAGVHAHWRVIPNGVDPERYRPAAPVQTNTPAQADTPVQADTAVQVATVVQAG
                     TTGPTGTTAVRTALAPLAGLDPAALLVVCVGRLCRQKGQDVLLQAWPSVLRRVPGARLV
                     LVGDGPEEERLRQRAPEGVLFAGAVTDTVPWYQAADLVVLPSRWEGMALAPLEAMACGR
                     PVVVTDVAGARESLPPGHRTHCLVPPGRPGPLADALTGALLDPPLRESLGHQGRRHVLT
                     THDVRHSAEAVAALYRELLDSGRTVTQEHIECRESIRS"
     misc_feature    complement(7382..7395)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            8668..10137
                     /locus_tag="CES90_RS43425"
     CDS             8668..10137
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065681.1"
                     /locus_tag="CES90_RS43425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exopolysaccharide biosynthesis polyprenyl
                     glycosylphosphotransferase"
                     /protein_id="WP_229914527.1"
                     /sec_met_domain="Bac_transf (E-value: 4.3e-58, bitscore:
                     194.9, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKRTVSPPAAQQPDQGFLSVPVLPPRGVREGFGSPARQRARRA
                     PALSLLVMDATAALTAVPTLPHPLLAAPLLLAVLWLNARAALYRPAAVPAVLDELPAVC
                     ARIAVSWCAVAALVAALSPAHALSARTLLTCCAVQTAASCAGRGVVHWRRRRELLRSPA
                     AALVVGPAATAQRVAAAFLRHPGCGLRPVGVLADDMTGGAGLPVLSTDEEVRRAVVQNG
                     VRAMLLVGPAGEHGPLVRELSEAGCALWEVDTHVPSYEEAGHPVDDLSTEPAARRRGPR
                     ERIAGFSCRRLDTGRHPVGSAKRVVDVLVSGVLLLLAAPVLLACAVVLRVSEGPGVIFR
                     QERVGKDGLPFTLLKFRSHRPADAHEAATRWSVVDERDMSRFCRFLRRSSLDELPQLWN
                     VFRGDMSLVGPRPERPYFVATFSQAHPGYAARHRMPTGITGLAQVNGLRGDTSIEDRAR
                     FDNAYIDDWSPWQDVCILLRTAAALLRPTGS"
ORIGIN
        1 cgagacccgc gggccgtgcc ggtacccgcc tacggcgaac cgctccccgg acgcgtgaag
       61 gtcgcggtcg tggcggaccc tggcgggcac ggcgtccacc ccacggttcg cggagccatc
      121 gcgtccgcgg ccgacgcgct ccgcgacgct ggatacgacg tgcgcgagga gcaggacgta
      181 ccgcggatgg acgaggccct tgaggcgtac ggccggatca ctgtgaccga gttcgccccg
      241 acctggccgg tggtgcgcag gctgctcggc aagggcgggg accgctatat cgagatggcg
      301 atggagcaga ccccgcccgt aagcgcggag gagttcatga agttgatggg cacctggatg
      361 aacatccgcc gctcatgggc cgaattcctc aacgaatacc cgctgttgct cggcccagtc
      421 ttcaccgagc caccggtcga gccggggctg gagtcgcgtg acaggtcagg tagggaccgt
      481 gtcgggtcgg gaatgcgcct gtgcaccgtg accagtttcg tgggcgtacc cggtgtggcc
      541 ataccgaccg ggatggtcga cgggctcccc tgcggagtac agatcgtcgg gcgcgcgttt
      601 cgggaggacc tgtgcctggg cgcggcccag gcgatcgagg accggctcgg agttctcaca
      661 ccgctcgacc cgcgtgtggg aagccgggct tattgagccc ttgggccata gagggcgcgc
      721 gcggcggccc ccgtacccct cacgcccccg tcccggcggc ctggctgaaa cgcacccgtt
      781 cacgacgaac cgctctcaac ggcagcccga gatcacggta cttgtagaga cgcccgaggc
      841 tccaacgacg atcggcaccc gaaacaacaa ccggaatgga caccatgaac cccgccgagg
      901 actattcgcc ctcctgccgc gacttggtcg gtctcctcgc ccagaccgac cggcgcgccg
      961 cctacgcggc cctcgccctc ggcgcgacct ccgtggcgga ggtcgccgaa ctgaccaagc
     1021 tccgcccacc ggccgctgcc gcggctctgc agaagctgac ggacggccgg atcgccgcct
     1081 tcgacagcga aaagcgcacg tacacgctgc tcgacgacac ttttcggctc gcagtccagg
     1141 ccgaggtcag cgtctccggc cggggcagcg gagacggggc gggctcctac ttccgccgtg
     1201 gtcggctcac gtccattccg ggcaaggcgg aggtacgcag ccgtgttctg gccgttgtga
     1261 aggactcgtt cgagcccggc gtgacttact ccgaggccaa ggtcaacgcg atctgcggcg
     1321 aatggttcga cgactgggtg agcctgcgcc gtgccctcgt ggacgagggt ctgttgcgca
     1381 gaaacgagtc cggcaccacc tacgagcgcg tctgacggat ggtgcgagta ttggccggcg
     1441 acgcccgcac acccgaggat gccaccgcgc cgacctgcaa cgcgcttcga ccgatcaagg
     1501 caacggccgt tcgctgcgca gcctgcggac ctcgccgtat gcggtctcca gtcgtcgggt
     1561 gagttcgctg ttctcggccc gcagatggtt gatgcgcgtg agcgcgatct ccagacgtcg
     1621 ctggatggac gtggccgagg cgggttgcaa gccggtccgc tggctggagg gccgccggtt
     1681 ctgcaactgt cggatggccg tgaggagatc ttgttgcgtg tagagccagg accttgaaac
     1741 acccgcttcc ttcgcgatcg ccgcgaagct ggtgtggctg ccggtgcgct gggccgctga
     1801 gatggccttc tcggcgttgg ttcgggcacg ccggctgcgg cgtcgggggg gtcgaagccc
     1861 gaagcctctt cgaagcactg gtcaccgacc aggcgaccga cccgtcccgg ccccacccac
     1921 cgtcgcccgc cgaccaaggc cacgcactgt gggcaggggc ccggcgccac gcgaagggaa
     1981 tcggcccgtg atgacgtacg gccctcactg gctcgacggt gtggtctgcg gcggaacgag
     2041 tgccggtgtc ccatgaggat ggcgatgccc aagtacatgc ccaccagcat ggtcagggca
     2101 gagcgtggtg gagggcgctg ccgttggccc aggagccgac ctcgcacctt gtagaggccc
     2161 gcggatccga agaggaacca ggcccggcag cgatgacgaa ctcgcggccc aagcgaaatg
     2221 accagttgca gggaggcatt tcatctgcgc cgtttccgtg cgtgtgccat gcgcgggagt
     2281 tcctcgtgga gcagtcggcc gaccagcgca ccgccgaaga cgacgatacc cacgccgacc
     2341 agccaggact ggatgacgag gacggttccc atggggccgt aggtgacggt gttggaggcg
     2401 atcaacggcg agaagacgag cctggagaag accctcaggc cgagcagccc gatcacggtg
     2461 gccacggcgc cgggaaacag ggcacgccag cggatcctcc cgccgagcag caggcgctgg
     2521 gaccaccaca gcaacaggac ggcactcagc gacacgacgg ccccacctgc caggggttca
     2581 cgccgcagcg cggtggtggc ggagacgtag agatatccgg tgaggacgcc gagccacatc
     2641 acatgccgcc acctggccca ccagcgggcc ggcgacaggc cccagacctt ctcatagccg
     2701 gtctgcaccg ccgccccgaa ggtcagaccg aacacggcaa gggcggcgat accgaacgcg
     2761 gtcgtggtcc gcagtgcctg gccgggcccg gtgaacaact gctcgacctg ccgcatggag
     2821 gccgtcgaca ctccgagccc ttctcccagc cactgcgcga acccccgccc gtgctcggga
     2881 tcggcagagg agacaatgat cagcagcggc accagcgtga gcaatcccag cgccgcgaaa
     2941 cccagcgagc gcgaccacag ctcaatttcc ctgctccgcc gccatccgcg cccgactggc
     3001 gaatggctga tcaggcggtg cagcggcccg aaccgagagg aacggtccgc ggcaccggaa
     3061 ggcttcatcg gcatgcctgt cgactaccac gttcggaacc cctgccgcgt gagggcacga
     3121 agcagagata cccggataac ctggaagaac aaagggctac cgggctcagc gggctgccac
     3181 tgcccgaggg ggcggcgcgt accggctcgg atcaacggct caggaggcag accatgatcc
     3241 attcagccga tatccgcgag tggcgcaacc gcagcgtcgt cgacccgaag ggccacaaga
     3301 tcggcgtact cgaagcggtc tacgtcgaca ccaccaccga cgaaccggcc atggccacag
     3361 tccgcaccgg actccccatc cgccaccacc tggccttcgt ccccctcgac gaggcgaccc
     3421 tcggaccgga ctatgtcaag gtctcctaca ccaagacgct ggtgaaaaag gcaccctggg
     3481 tcggcatgga cgacatcctg cccgccgagt cggaggaagc aatcttccag cactacgaca
     3541 tgccctacca aacgggcgca ggcggcgagc ggcaactcgc gcgccgctga tcgcccgctc
     3601 agccacccaa gggaggtgga cgcgtcatgg ccctcttgct atttctcgtt ctgctcgccg
     3661 tcgtgctggg aatcatcgga gtggccgcag aaggggtggg ctacctactg atcatcggca
     3721 tcgtgatcct tgtggccgcg ctgggcctca tcgccgtccg ctggtcccag cgcaccggtc
     3781 gccgccccct ccgataacga acggcaccct gttactccgt ggaggcccag ccgttgggag
     3841 ccgttcggga gcagggccgc tcgctggacc gtcacgcacc cagcagtagt cgaggccggt
     3901 aggaccgttc ccgagaatgc cggaaaatgc ccttgccagc cggtcaggac aacgcgtaag
     3961 agcaggtcag aggcacagca gacgcgcccg gccaggcgcc ttccaagcgc ttggccgcag
     4021 gttcgagtcc tgccgggggc gccacggaaa gccctccctt cgcggagggc cttttcacga
     4081 cctcgtcgtc accgcccgcg cacacgttcc cgcccccctt cccccctcac gcataccctc
     4141 cccgtacggg ctacgcgtac cggtagatcc cgctgaggtc ctccagggag tccggcgtca
     4201 cgtcccaggg cggcatcggc tcgtgccgcg cgacgacccg gccgcgctgt ccgctgccca
     4261 gggccggctg ctcggcgggg agatagcggg cgttcgggtg ccgtcgctgc cagcgggacc
     4321 agaggaggtc gacgaaggcg tggtgcatcc agaagacggg gtcgttgacg gaggcgccgc
     4381 cgaccatgtg gccgccgacc caacggtgga cccggttgtg ggtgagccac gaaactacgc
     4441 cccgccccga cccccaccct tccagcctgt tgcggaaccc cttggcggac gtggagttcc
     4501 agggggccgc gtcgtaaacg ggatcagcga gggcccgttc cagatccccg gccctgggca
     4561 gcgcgatcgg gtcccgcgag cgccccaggt cgcgcgtgag gaactccgtg tcggtgatcc
     4621 ccacctcgat ggtccactgg ccgttgcggt aggcgaacgg gccggtcatc acctgccggt
     4681 cggaccgccg cccggtgccg ccgagcaggt ccgcggtcca cggtacggcc gtcgtgccgc
     4741 ggttgcgtgt ccagtcccag tacggcacgg tcaccctgtc gtccacgcgg cgcagcgcct
     4801 cctccaggtc cagcaggaac ttgcggtgcc agggcaggaa ggtgggggcc atgtgggcga
     4861 cacgcagccc ggcttcgccg tcggagcggt agtactcgat gtgtgtgcgc acgaactcgt
     4921 cgtactcgcc acggcgtttc acctccagca gcgcgttgac gaaccggtgc cgctcggacc
     4981 gggtcagcgc actgacgtcc ttacgcgtgt acaccacggc ggtgatccct ttcggctccc
     5041 tcgcacccgc tcggcgtgcg gctgccgtcc gtacgactgc ttctgtcacc cggcgcgccc
     5101 agccgtgcgg tggggccgag ctcgtcgact gccgcgcggg cggcggcgag cggggtctcg
     5161 tacgactggt agtggtcgat catgctcatc cagctaccgt ccgcccggcg catcagatgc
     5221 agcggccggc cgtccaccgt gacgtgccac gtgccggggg taccgccccc ggacggcccg
     5281 tcttcgtgcc tgacgccgac gattcggcgg ccgcgatacg tctcgtcgaa ccgcgtttcc
     5341 tccgttccgg ccgatctcga cgccaccagg aagggcgcgg gcgtgatccc gagcgccgcc
     5401 acgaacgctc cccgcaacac tcgccgtcgc cccgtggtct ccccattccc aaagaatctg
     5461 ctggtcgcca acgttctgtc tcctcctcgt catggaaacg gacccgccca tacacggaat
     5521 ccttacaagg agccttttct ggaatcctca agaagagcct tcacacagaa tccctgtgcg
     5581 caacataatc aaagggccga tcccgcattc ggcggaatcg gcccagggac gtcacaagcg
     5641 tccgaaccgc tcagttctgc aaaagttctc agcccgccag cttgccaccg ttgccgagtc
     5701 cgcccgtcgc cccctggagg gtgcccgcca aaccctgcct cgggtcgagc accttcttcc
     5761 cgttcagctg gacaccgtca gtgatgccgg tcaccgcctg accgaggccg ccggactggc
     5821 tccccggggc gtccagggcg agagcgggag tggcgaaacc ggccacgacc agggacccgg
     5881 caacgatggc ggcagccttc agagacttca tcgtatttcc tttcttcggc aacccgaaag
     5941 tcgccagcgg gaattacttc atcgacacca acgagccccc gccgccgagg aaaccccgaa
     6001 cacagaaaat tccggcccgc cgcaggaagg tcacccgaat gaatgaggag cgtttcttat
     6061 ccgcgtttcc catcctccta tgaacgcgga ctcctatgaa cgcggactcc cgtgacgcgg
     6121 gcgctgcccg atgacgcgcg cgagccggcg cacctcatcg gacagcgagc gaactcccct
     6181 tctcaggaag gctgctccag gggcacgggc aggccgggca ggctgggcac ggcaccgagc
     6241 aggagggcga cgacgacgct tgcgagcttc gtcgacacgc ccgtgaccgc ggagagggcg
     6301 ccggacacgt caccggtctt ggcggcggtg accaactgat ccacggcctt ctgcagctcg
     6361 gcgatcgcat ccgtcagggt gtcggcgggc gccgtctcgt cacgtgcctc gttctccgcc
     6421 aactgcggta cgaacgccgg gttcgccgac acgttcggaa cggtcggcgc ggcgggggtc
     6481 gtcatccccg gagtcgccgg gttcgcgggg ttcgcggggt tcgcggggtt cgcggggttc
     6541 gcgggagtca ccgcggtcgc ggcaaccttg gcgatggcag ccttggcggc gtcgccgagt
     6601 ctctgcgcat ccgcttcgga cagccggtgg ttcggcgcct tgagcacggt gtccatcaga
     6661 gtggtgaccg gggggaccac gatgccgatg gagcccaggt gcgctacctg cccctggagg
     6721 gtttccgcct cggagacggg agccgactca cgggtacggt cccgtgccgt gtcggccgcg
     6781 agggcggtgg gtgccgtgac accgatcaga aacgtggcgc acagggccga ggtcgcgatg
     6841 cgccgtgccg tgaaagtacg catggaagtt cctttcgcaa gggtgcgtgg ggtcctgtag
     6901 ccacctttga atcggtgacc acaccttgca accggacaag cgcacagtgt gactgtccga
     6961 ccctttacgg cacggcgtcg ccgctggtgg gcgaccctgt cgaaccctcc gaccgctccg
     7021 tcccgttcgg cgcagcgctc aagcgggagc gcgacgcacg ggcggaagcg cggacacgag
     7081 ccggcccgga tgcgacggcg accgtgcggg accgtcgaca cgagaggagg gatttgaaca
     7141 cttcatcact cttgcccgaa atgcgaggta ttccgagata gggtgacgcg tcgtaagtca
     7201 gccgaacact tgacgttcct cgcgaaaggg caacgccagt catgcgtcac gcccggggtc
     7261 tttccactgc gacacgcacg gggctccgcc cgtccgacgg cctgtccgac ggcccgtcag
     7321 gccgggacgg tcgcccttcg gatcgactcg cacggtgatg gtcagccgac ccatcggatc
     7381 gtcgcgcagc gggacgcggc ggggcactgc accgcgcgtc ctccacgtca cccagccggt
     7441 ggacggcggc gtcactcacg tcgtcaccga gctggtgcgt gcgcagcgcg cggacggttt
     7501 cgacgtcacg gtcgcgtgtc ccgacagcca cttcgcccgg acgatgcggg aactcggcgc
     7561 ggacgtacgg ccctggcacg ccacccgcgc gccggggcgg tcgctgcccg atgaggtccg
     7621 tcggctcgcg cgtgtcatcg acgaggtgcg gcccgaggta ctgcacgcgc acagcgccaa
     7681 ggccgggctc gccgcccgac tggcggtcag ggggcggatc ccgacggtgt tccagccgca
     7741 cgcctggtcg ttcgaggcgg tcggcggagt cacggcggtg gccgccacgg cgtgggagcg
     7801 gtgggcggcg cgatggaccg cccgggtggt gtgcgtcagc gaagctgagc acgcgagggg
     7861 cgtacgcgcc ggagtgcacg cccactggcg agtgatcccc aacggtgtcg acccggagcg
     7921 ttaccgcccc gccgcccccg tacaaaccaa cacacccgca caagccgaca cccccgtaca
     7981 agccgacacc gctgtacaag tcgccacggt cgtacaagcc ggcaccaccg gcccaaccgg
     8041 caccaccgcc gtacgaactg ccctcgcccc gctcgccggc ctcgatccgg ccgccctgct
     8101 ggtggtctgc gtgggacgcc tgtgccggca gaaggggcag gacgtgctgc tccaggcgtg
     8161 gccctcggtg ctgcggcggg tgcccggcgc caggctggtg ctcgtcgggg acgggccgga
     8221 ggaggagcga ctgcggcaac gcgcgcccga gggcgtgctg ttcgccggag ccgtcaccga
     8281 caccgtgccc tggtaccagg ccgcggacct ggtggtgctg ccgtcccgct gggagggcat
     8341 ggcgctggcg ccgctggagg cgatggcgtg cgggcggccc gtggtggtca cggacgtggc
     8401 cggggcgcgc gagagtctgc cgcccggtca ccggacgcac tgtctggtac cccccggtcg
     8461 gccgggcccg ctggccgacg cgctcaccgg ggcgctgctc gatccgccgc tgcgcgagtc
     8521 tctcggccac caggggcgcc gccacgtact gaccacgcac gacgtgcggc attccgccga
     8581 ggcggtcgcg gccctctacc gcgaactcct cgactccggg cgcacggtga cccaggaaca
     8641 catcgagtgc agggagtcca tccgctcgtg accgtcaaac gcaccgtctc tccgcccgcg
     8701 gcccagcagc ccgaccaggg attcctgtcc gtcccggtcc tccccccgcg cggggtccgc
     8761 gagggtttcg ggtcccccgc gaggcagcgg gcgcggcgtg ccccggcgct gtctctgctc
     8821 gtcatggacg cgacggccgc gctcaccgcc gttccgaccc tcccccaccc cctgctggcc
     8881 gcaccactgc tgctagccgt cctctggctg aacgcgcggg cggcgctgta ccgccctgcc
     8941 gccgtgcccg ccgtgctgga cgaactcccc gccgtctgcg cccggatcgc ggtgagctgg
     9001 tgcgccgtag cggcactggt cgcggcgctc tccccggccc acgccctgtc cgcccgtacg
     9061 ctgctgacat gctgcgccgt gcagacggcg gcgagctgcg ccggacgcgg cgtggtgcac
     9121 tggcgccgcc gccgggagct gctccgcagc cccgcggcgg ccctcgtcgt gggcccggcg
     9181 gccaccgccc agcgcgtggc cgccgccttc ctgcgccacc cggggtgcgg cctcagaccg
     9241 gtgggtgtcc tcgccgacga catgaccggc ggtgccgggc tgcccgtgct cagcacggac
     9301 gaggaggtgc ggcgcgccgt cgtccagaac ggtgtgcggg ccatgctcct cgtcggcccc
     9361 gcaggtgaac acggcccgct ggtaagggag ttgtccgagg cgggctgcgc actgtgggag
     9421 gtcgacacgc acgtaccctc gtacgaggag gccggccacc ccgttgacga cctgtcaacc
     9481 gagcccgcgg cccggcgccg tggcccgcgc gagcggatcg ccggcttctc ctgccgacgc
     9541 ctggacaccg gccgacaccc cgtgggatct gccaagcgcg tcgtcgacgt actggtctcc
     9601 ggggtgctgc tcctgctcgc cgccccggtg ctgctggcct gcgcggtcgt gctgcgggtc
     9661 agcgaggggc ccggagtcat cttccgccag gagcgcgtcg gcaaggacgg cctccccttc
     9721 acactgctga agttccgcag ccaccgcccg gccgacgcgc acgaggccgc gacccgctgg
     9781 agtgtcgtgg acgagcggga catgagccgg ttctgccgct tcctgcgccg gtcctcgctc
     9841 gacgaactgc cccagctgtg gaacgtcttc cggggcgaca tgagcctcgt cgggccccgc
     9901 ccggaacgcc cctacttcgt cgccaccttc agccaggccc atcccggata tgccgcccgc
     9961 caccgcatgc cgaccggcat caccgggctc gcccaggtca acgggctgcg cggtgacacc
    10021 tccatcgagg accgcgcccg cttcgacaac gcgtacatcg acgactggtc gccgtggcag
    10081 gacgtctgca tcctcctgcg tacggccgcc gcgctgctgc gcccgacggg gagctgaacg
    10141 cggtgagcca cgcatgcgcc ccgcccgccg cgcgcgggct gacgcccgtc ctgccggtgg
    10201 tcgcggtgat cgccctggtc gcgctgcccg tcgcggcggg cggcgagggc ggcgcgacac
    10261 ccgtcgacgc cgcctccggt gtcgtagtcc tggcatgcgc gatccgtctg ctgcggcagc
    10321 ggcggcgccc cctgtcccgt accgccgcgg tggtgctggg cctgcccgtg gccgggttcg
    10381 cggtcgcggc ggtgggagcc tccgaaccgg gcgcggcgct caccggcttc gggcgcggtc
    10441 tgcagatctt cgtgctcgtc ccggccgctg t
//
