LOCUS       NZ_CP022161            21050 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8386032
            Orig. end                         :: 8407082
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21050
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="34"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21050
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21050
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11050](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11050)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(85..909)
                     /locus_tag="CES90_RS37705"
     CDS             complement(85..909)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113592.1"
                     /locus_tag="CES90_RS37705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_189780823.1"
                     /transl_table=11
                     /translation="MSLHPTLQPYADAWTHSVDAISELVSPLVEGEWNRRTPCPGWSVR
                     DVVSHVIGLDCEMLGDPRPIHTLPRDLYHVRTEHQRYMEMQVDARRHHTAPEMTSELEY
                     TIIRRNRQLRNESRDPGHKVRGPLGTEVTLEQAMRNRAFDVWVHEQDLRAALGRPGDLD
                     SPGAYVVRDELLSVLPKVVAEDARAPRSSAVVFDVHGPVEFIRTVRVDMQGRGTLETAP
                     ALGPAATLTLDWETYVRLACGRVTADLVADRIKGEGDPQLIAEILRSFAVTV"
     gene            1145..1939
                     /locus_tag="CES90_RS37710"
     CDS             1145..1939
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483092.1"
                     /locus_tag="CES90_RS37710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbon-nitrogen family hydrolase"
                     /protein_id="WP_189780822.1"
                     /transl_table=11
                     /translation="MRASLIQIGVNEDESVDSRRRRVASLVREQAGADLVVLPELWTTG
                     AFAFESFTAEAEPLEGPTFEVMAKAASDAGVWLHAGSIPERDPEGPLYNTSLIFSPSGE
                     LAAAYRKIHRFGFDKGEAVLMGAGSELVTLRLPETTIGLATCYDLRFPELFRGLVDAGA
                     ETLVIPAGWPERRRAHWTLLAQARAVENQSYVLACGTAGTHAGVPQAGHSIVVDPWGEV
                     LAEAGSDEEILTVDFDPTKVPTTREQFPALKDRVLGLPTPRR"
     gene            complement(2043..3050)
                     /locus_tag="CES90_RS37715"
     CDS             complement(2043..3050)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975132.1"
                     /locus_tag="CES90_RS37715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_189780821.1"
                     /transl_table=11
                     /translation="MPKGSSQHSPPLPHRVAIVVDEATNPFEVGVATELFGLPRPELGL
                     PGPLYEVTLCTPQSEVRMNHGFFTMTGVAGLDAVDDADTLVVPGRPDNVVPRGPAVLDA
                     IRCAHARGARVVSFCTGTFALAEAGVLDGRRATTHWRWADAFRELHPKVRLEPDVLYVD
                     EGDLLSSAGSAASLDLGLHIWRLDHGAEIANAVSRRLVFAAHRDGGQRQFVERPVPHIP
                     DESLAPVLAWAQERLDEPLSVADLAARAAVSPATLHRRFRAQLGTTPLAWLTGERVNLA
                     RRLIERGEERLDIVAERSGLGTAANLRARLRRETGLSPSAYRRRFGAGPGKRNA"
     gene            3102..3506
                     /locus_tag="CES90_RS37720"
     CDS             3102..3506
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055235.1"
                     /locus_tag="CES90_RS37720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cupin domain-containing protein"
                     /protein_id="WP_189780820.1"
                     /transl_table=11
                     /translation="MESTEPTEPISLFDALTSFDALWSPRIVTTVNDYDVRVAKVEGEH
                     LWHTHDHTDEFFLVIEGELHISLREPSGERTVVLPQGSVFTVPRGTEHKPYAPARAAIL
                     VLEPTGTLTVGDRHDEIPDHVDATTGHALA"
     gene            3598..5460
                     /locus_tag="CES90_RS37725"
     CDS             3598..5460
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009336556.1"
                     /locus_tag="CES90_RS37725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHL domain-containing thioredoxin family protein"
                     /protein_id="WP_189780819.1"
                     /transl_table=11
                     /translation="MNDTTTQHPTPRRVRVRAPELIGKGGWLNTGGKQYTLADLRGKIV
                     VLDFWTFCCVNCLHVLDELRELEEKHRDTVVVIGVHSPKFAHEAEHRAVVDAVERYEVE
                     HPVLDDPELATWKQYAVRAWPTLVVIDPEGYVVAQHAGEGHAHAIERLVAELEAEHGAK
                     GTLRRGDGPYVAPDPEPTVLRFPGKALLLPDGDFLVSDTTRHQLVRLAADGETVVRRYG
                     SGERGFVDGTAEHARFSEPQGLALLDNATVVVADTVNHALRRLDPATGEVSTLAGSGRQ
                     WWQGAPTSGLAWEVDLSSPWDVAVFAGKVWIAMAGVHQLWTYDPADCTVAVAAGTTNEG
                     LVDGPGADAWFAQPSGLAATADRLWLADSETSALRWVDLDGVVHTAVGTGLFDFGHRDG
                     AAEQALLQHPLGVTVLPDGSVAVSDTYNHALRRYDPATGEVTTLATDLREPSDAVLVGD
                     DIVVVESARHRLTRLRLPEETVKVEAVAHRTQRAATEVAPGSLRLEVIFQAPPGQKLDE
                     RYGPSTRLLVSATPPELLLRGEGADPALSRTLELNPSISEGVLHVSAMAASCDDTASNS
                     GSAAGANEYPACHVHQQDWGVPVRITDGGADRLPLVLAGMDESL"
     gene            5748..7745
                     /locus_tag="CES90_RS37730"
     CDS             5748..7745
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823207.1"
                     /locus_tag="CES90_RS37730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M28 family metallopeptidase"
                     /protein_id="WP_189780818.1"
                     /transl_table=11
                     /translation="MPVLFFDIGATLADAREEVDGSLTLVPRPRVLAVLDAFGDVRKGV
                     ISNPGPGEGAAERAASALREAFPGRFTDDALIHWGPKNSREIFDEAVAGTAGEGIPASA
                     AGECVFVGEDHQERAFAGQAGLRTAAHPVFTGAALENRPVLWARIELPEDRGLPALETV
                     ANRTEVVPVHIASARLVLAMASMRGAAALEQAGFTVDLRGPVEDTAAFLIRDDRPLTPA
                     QGFEDVPERATTRATSAFGVVADELAGLTAPPLLPLGPAPGGVYVAVPAGAPIEDVHLP
                     GAKPGHTERLLPDPALLSRPGEAWAQGLAAGPTERMEGATEVPAEPGRPASAAGDGRPS
                     PETIAAVRAAVTPQALRGHVARISGVEPLRDGEALLVRSRDASAADNPRVVEALADRFQ
                     NLGLDVRLHRFRWRGRPLFNVEAEHRVAGADSTVLITAHLDSTASNGAFVDENGDPRPY
                     DPTVDPAPGADDDGSGTAAVMAAAECLHHLLAEGRTPTRNVRFVLFNAEEQGLVGSKFY
                     ARAAAAADDRIAGVFQMDMIAGRQQGSTPTVEIHAGSSVPGPVVDASDRLGALVADTVP
                     AVDPAVTVQQLMGPSDPAIGRSDHASFHERGWAAIAVSEDIFAPDGGPGTGTRQYHTPG
                     DTLIDRDHSPEFAATVARSVTATALTLAGL"
     gene            7875..9890
                     /locus_tag="CES90_RS37735"
     CDS             7875..9890
                     /GO_component="GO:0005615 - extracellular space [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014214.5"
                     /locus_tag="CES90_RS37735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M36 family metallopeptidase"
                     /protein_id="WP_189780817.1"
                     /transl_table=11
                     /translation="MTQLIDKRDLQYDRLARVRGAEAFLAQTDRVAESVHHTLIADDSK
                     VNRFTGHLTELRVEGAPADLAERAGAEAADGDYIVRAKEYLSSVSEAIGFAAGEPAEFE
                     ADPKVTSTSGGMRVVSLQQTLNGIDVWGMAPKVWLRQDGTVDRVVGDTASVPSNVPTMP
                     AVPVETALAAGAAKAAEPVTIDGLFGTDELPALDLSEGLRRLSSQARNDQPMTFDKGAF
                     DEAIPARLVYFYMGDTVRLAWSFRFSRAKGAVQYHALVEADERTPDKAAPQVLYLQDLT
                     NHVVGGLVFRQNPAETGYALASFPLPLSDYPVEPPPEPLPGFPGPWAERQNGQVATAGN
                     NVHAVDGDTGESFKVGVDTSGNGVFAPNPDTPEQLVTNIFFFCNYMHDFFVMLDFTEEH
                     GNFQTVNFSGLGHGADPVVALAHPGPVFGTANMLTPPDGRAAEMNMGLVAGTGRHTAND
                     AHVVFHEFTHGVTNRLVGGLHDANGLREDQSRAMGEGWSDYFALTIPNFFREREHIVVG
                     AWVVDDPGGIRQRPYDDRYPGGFGDIGQAKGGLDYTRIHNVGEIWCAALMEMTRRISAE
                     LGSKERGYRVAWQAVVDGLKLTPKNPSFLTARGAILRALKDLKGTAFTEAEYPEVRKAA
                     WGSFARYGMGFDAFCPNASFFGCRAGIQLPPAGHED"
     misc_feature    complement(7887..7901)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(10001..11050)
                     /locus_tag="CES90_RS37740"
     CDS             complement(10001..11050)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="CES90_RS37740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189780816.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.1e-48, bitscore:
                     164.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEPGVGLGPSAVESVLTRYRDLTMARLLSDIPDSAEDELYSLV
                     RDYPSRSGKGLRPALCLAVCRALGGDIEKAIDSAVAIELTHNAFLILDDVQDGSEMRRG
                     APTLPAEYGLGVAVNVGSATNLLALQHLMANRWALGPNLAWAILQESALMMRHSLEGQA
                     IEVGWIRNNACDLVDDDYYRMCMKKSSWYTCIHPCRVGALVAEGKHRATARFDRYGCYL
                     GAAFQIQDDLLNLTGHYSRYGKEISGDLREGKRTLVLIEYMRRCTAAQRARMERFLGRT
                     RAARTEDEVRWVRDELLASGCVETVRARARALADEAHREALKAFDDNPDSEDKQFLLDL
                     PYYMVERDS"
     gene            complement(11064..11540)
                     /locus_tag="CES90_RS37745"
     CDS             complement(11064..11540)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS37745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189780815.1"
                     /transl_table=11
                     /translation="MPDEHLNRVDPERLELSRAVSQVVKQAATILQQELTDGSGRATAM
                     QKKYATTKKVDPNEFQLLSSRVRKDVHDLIAMAAEMFSELKTNEVQSLVSRMATDAHDV
                     VDTTMNLVENTPATARTLANLGFTTPPPAGPTPLTDDGDTPASDSGDEPPRPSA"
     misc_feature    complement(11562..11575)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.82"
                     /tool="antismash"
     misc_feature    complement(11568..11581)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.36"
                     /tool="antismash"
     gene            complement(11640..11882)
                     /locus_tag="CES90_RS37750"
     CDS             complement(11640..11882)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483113.1"
                     /locus_tag="CES90_RS37750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6458 family protein"
                     /protein_id="WP_189780814.1"
                     /transl_table=11
                     /translation="MGLGGCIILIAVGAILTFATDWDMQGVNLDLVGVIFMIVGLIGVA
                     TFSSIARRRRVVVPPATPVIDDDRHRHHRDGYQGY"
     gene            complement(12017..13315)
                     /locus_tag="CES90_RS37755"
     CDS             complement(12017..13315)
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009336522.1"
                     /locus_tag="CES90_RS37755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M18 family aminopeptidase"
                     /protein_id="WP_189780813.1"
                     /transl_table=11
                     /translation="MRTPPRFDRGHTDDLMTFLAASPSPYHAVASAAERLEKAGFRQVS
                     ETDAWDGTLGGKYVLRGGAIIAWYVPEGATPHTPFRIVGAHTDSPNLRVKPRPDSAAHG
                     WRQVSVEIYGGPLLNSWLDRDLGLAGRLSLRDGTSRLVNIDRPLLRVPQLAIHLDRTVS
                     SEGLKLDKQRHLQPIWGLGDDVRDGDLIAFLEEESGLPKGEVTGWDLMTHSVEPPAYLG
                     RDKELLAGPRMDNLLSVHAGTAALAAVATSGDELPHIPVLAAFDHEENGSQSDTGADGP
                     LLGGVLERSVFARGGSYEDRARAFAGTVCLSSDTGHAVHPNYAERHDPTHHPRADEGPI
                     LKVNVNNRYATDGSGRAIFAAACERAGVPLQTFVSNNSMPCGTTIGPITAARHGIRTVD
                     IGVAILSMHSARELCGAKDPYLLANALAAFLEG"
     gene            complement(13830..15656)
                     /locus_tag="CES90_RS37760"
     CDS             complement(13830..15656)
                     /EC_number="1.3.8.-"
                     /GO_function="GO:0003995 - acyl-CoA dehydrogenase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991606.1"
                     /locus_tag="CES90_RS37760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_189780812.1"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.1e-18, bitscore:
                     65.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.6e-15, bitscore:
                     55.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGHYKSNLRDIEFNLFEVLGRDKLYGTGPFAEMDTDTAKSILEEL
                     TRLAENELAESFTDADRNPPVFDPETNTAPVPASFKKSYKAFMESEYWRLGLPEGIGGT
                     TAPASLIWSFAELILGANPAVWMYSSGPAFAGILYDEGNDVQKKIAQIAVERTWGSTMV
                     LTEPDAGSDVGAGRTKAVQQEDGSWHIEGVKRFITSGEHDMEENILHYVLARPEGHGPG
                     TKGLSLFLVPKYLFDFETGELGERNGVYATNVEHKMGLKASNTCEMTFGDRHPAKGWLI
                     GDKHDGIRQMFRIIEFARMMVGTKAISTLSTGYLNALEYAKERVQGPDLAKFMDKTAPK
                     VTITHHPDVRRSLMTQKAYAEGMRALVLYTASIQDEIAVKEAAGEDVSALHALNDLLLP
                     IVKGYGSEKGYEQLAQSLQTFGGSGFLQEYPIEQYIRDAKIDTLYEGTTAIQGQDFFFR
                     KIVRNQGAALNSLAEEIKKFLALGEGGEQLAGAREHLAKAAVELEAIVGLMLTDLAATE
                     QDVKNIYKVGLNTTRLLLASGDVIVGYLLLKGAAVAAEKLPNASAKDKAFYTGKIAAAK
                     FFAANVLPGVTLARKISETVDLDLMELDEAAF"
     gene            15805..16302
                     /locus_tag="CES90_RS37765"
     CDS             15805..16302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055242.1"
                     /locus_tag="CES90_RS37765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SseB family protein"
                     /protein_id="WP_189780811.1"
                     /transl_table=11
                     /translation="MYGYDQSAGTQQQYAPPPQQQMPGQQMPGGPMGGGYGQQPPLYPE
                     PSPPSLADAVRAFTTGQMAAEDFQQVFATSKVYCPRGDNPGFLALHNTQQPVIPMFTSL
                     KELRRYAGKESKYFVITGAEVIDLLPTGYGFVLDMEGEHRMVFDAKAVEQMVEFAMRRM
                     YG"
     gene            16476..17339
                     /locus_tag="CES90_RS37770"
     CDS             16476..17339
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023580.5"
                     /locus_tag="CES90_RS37770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3592 domain-containing protein"
                     /protein_id="WP_189780810.1"
                     /transl_table=11
                     /translation="MTEIDTSPLVLYGRRRSVARLKAGVLLLDQGRIRRRIPVSAIERV
                     DVGGPRACELTVVLTAGTPPAVTYVLRARSAPMVREFAAAVSRALPVRDAEEPRHDGAG
                     LVSEEVVKRWSPSPAHWVATGLLIVYLLVPLILWVAGRTTPFVLWLLGPWVALLGLGSV
                     MGGWEAKEKAAALRTRGITVEGRLEYSYEERSGEDTVKKYVYSFADTSGEVHQRHGTQG
                     GGAERVEIVYDPADPKENNKVGRGTAVRLAGAWLLVLLVGVPAVVAGAAFMVVGVVALC
                     PWAGAE"
     misc_feature    complement(17425..17434)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            17468..18439
                     /locus_tag="CES90_RS37775"
     CDS             17468..18439
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483120.1"
                     /locus_tag="CES90_RS37775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pirin family protein"
                     /protein_id="WP_208921533.1"
                     /transl_table=11
                     /translation="MPAVTVENPLALPRVVAPADAVARPVLGVTTAPSGFEGEGFPVRR
                     AFAGIHYRHLDPFIMMDQMGEVEYAPGEPKGTPWHPHRGFETVTYIIDGIFDHQDSQGG
                     GGTITNGDTQWMTAGSGLLHIEAPPESLVMSGGLFHGIQLWVNLPAKDKMMAPRYQDIR
                     GGQVQLLTTPDGGALLRVIAGELDGHQGPGITHTPITLLHATVTPGAEITLPWREDFNA
                     LAYVLAGRGTVGADRRPIHMGQTAVFGAGSSITFRADEKQDSNAPDLEIVLLGGEPIRE
                     PMAHYGPFVMNTREELQQAFEDFQKGRLGTIPAVHGMAEGGI"
     gene            complement(18608..19045)
                     /locus_tag="CES90_RS51710"
     CDS             complement(18608..19045)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS51710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_308437827.1"
                     /transl_table=11
                     /translation="MRLEQRNLEADEMLAAFTEDRNHLLQQLNQSQSRIADALQDIAES
                     LRRPNRSHSTPEPEPELTPQDLLATWKAKNLVVTEDVHAVAACLAPALVRGEARYRLEE
                     ISTRTGLSQERVNDCLRMLLKRGCVRQRGCTEDGAPVYVLP"
     gene            complement(19061..19603)
                     /locus_tag="CES90_RS51715"
     CDS             complement(19061..19603)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014548.5"
                     /locus_tag="CES90_RS51715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Bro-N domain-containing protein"
                     /protein_id="WP_332836435.1"
                     /transl_table=11
                     /translation="MPASCSALCLASEAEVMLDVRAEQHAARRIGGTATGRHRHQRLRV
                     RGHGARMRRLTTPDGEHWFVAADVASNLGYANTRQALGWHVAPDCTKPLSEIAQGVYTV
                     DTSRKLADHRLQKSMKMVNLRGLVALVNGCTKPECAPFKAWVSDVITTIQRDGSYALEP
                     SPVQTPAVGPPAYVMPQ"
     gene            complement(19714..20040)
                     /locus_tag="CES90_RS37785"
     CDS             complement(19714..20040)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS37785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189780809.1"
                     /transl_table=11
                     /translation="MRTHAPRTRSVPKAFVTTAVGSALILGALAEPSWSAPDVAAKYPG
                     RLRRPRTHPGPQQRQHGERQHLHQVGHVRHVQRVARHGAGPNKLTWKNCEKATIVNKGD
                     NSRL"
ORIGIN
        1 ggaacgcctg gtggcgagca gggtggagac ggtgcacgta ccggcgtgag ccgacgctga
       61 ggtcgcgcgc cggcctcggt ggccctacac cgtcaccgcg aacgaccgca ggatctccgc
      121 gatcagctgg gggtcgccct cgcccttgat gcggtcggcg acgaggtcgg cggtcacgcg
      181 gccgcaggcg aggcggacgt aggtctccca gtcgagggtg agggtggcgg cggggccgag
      241 ggcgggggcg gtctccaggg tgccgcggcc ctgcatgtcg acacggacgg tacggatgaa
      301 ctccaccggg ccgtgcacgt cgaagacgac ggccgaactg cgcggcgccc gcgcgtcctc
      361 ggcgacgacc ttcggcagta cggagagcag ttcgtcacgg acgacgtacg cgcccggcga
      421 gtccaggtcc cccggccggc ccagcgcggc gcgcaggtcc tgctcgtgga cccacacgtc
      481 gaacgcgcgg ttgcgcatgg cctgctcgag cgtcacctcc gtgccgagcg ggccgcgcac
      541 cttgtggccc gggtccctcg actcgttccg cagctggcgg ttgcggcgga tgatcgtgta
      601 ctccagctcg gaggtcatct ccggggcggt gtggtgccgc cgggcgtcga cctgcatctc
      661 catgtaccgc tggtgctcgg tccgtacgtg gtagaggtcg cgcgggaggg tgtggatcgg
      721 ccgcgggtcg ccgagcatct cgcagtccag gccgatcaca tgggagacca cgtcgcgcac
      781 cgaccagccg gggcatggtg tccgccggtt ccactccccc tccacgagtg gggacaccag
      841 ctcggatatc gcgtccacgg agtgggtcca ggcgtcggcg tagggctgga gagtgggatg
      901 cagactcacg gaacgggacc cctcgggcgg tcggtacgtg tcagtacagt cggtacgtgt
      961 cggctacgtg gtgggtggtc ttcgtgggtg ggggcgtcgg cgttgacggc gggagtgggc
     1021 gtcggcggct gtcggtgggt gctgtggaac gttaagttac gctgctgaga ggcaccccgg
     1081 cagtgctttc gtgtgacgat cgtaggcccg atatggacgg ctcgaatgcc aggacggtgg
     1141 tagtgtgcgc gcctcgctca tccagatcgg tgtaaacgag gacgaatcgg ttgattcgcg
     1201 caggcggcgt gtggcgtcac tggtacggga gcaggccggc gccgatctcg tcgtccttcc
     1261 cgagctgtgg accaccggcg cattcgcgtt cgagtccttc acggccgagg ccgagccgct
     1321 ggaggggccg accttcgagg tgatggccaa ggcggcgagc gacgcgggcg tctggctgca
     1381 cgccggctcg atccccgagc gagaccctga gggccccctc tacaacacgt ctctcatctt
     1441 ctccccctcc ggcgaactgg ccgccgccta ccgcaagatc caccgcttcg gcttcgacaa
     1501 gggcgaggcc gtactgatgg gcgcggggtc ggagctggtg acgctccgcc tccccgagac
     1561 gaccatcggc ctggccacct gctacgacct gcgcttcccc gaactcttcc gcggcctcgt
     1621 cgacgcgggc gccgagaccc tcgtcatccc cgccggctgg cccgaacgcc gccgcgccca
     1681 ctggaccctt ctcgcccagg cccgagcggt cgagaaccag tcgtacgtcc tcgcgtgtgg
     1741 aacggccggt acgcacgcgg gagttccgca ggcgggtcac tcgatcgtgg tcgatccctg
     1801 gggcgaggtc ctcgcggagg ccggctccga cgaggagatt ctcaccgtcg acttcgaccc
     1861 gacgaaggtc ccgacgacac gggaacagtt cccggccctg aaggacaggg tgctgggact
     1921 gccgacgcca cgccgctgac ctgcgtcaac ggcccgccac cctggtgtgc gacggatagg
     1981 cgcgaggggc tcgccgtccc gttcgatcac catggtggcg cgcggtctgg aatctcatgc
     2041 cctcaggcgt tccgtttccc ggggcccgct ccgaaacgtc gtctgtaggc cgaagggctc
     2101 agtccggtct cccggcgcaa ccgcgcgcgg aggttcgcgg cggtcccgag tccgctgcgc
     2161 tcggcgacga tgtcgagccg ttcctcgccg cgttcgatga gccgacgggc caggttcacg
     2221 cgttctccgg tgagccaggc caggggagtc gtgccgagct gggcgcggaa acggcggtgc
     2281 agggtggcgg gcgagacggc cgcccgcgcg gcgaggtccg cgacggagag gggttcgtcg
     2341 agccgctcct gggcccatgc cagtacgggg gccagggact cgtccgggat gtgcggaaca
     2401 ggccgctcca cgaactgccg ctgtccgccg tcgcgatggg cggcgaagac cagtcgccgg
     2461 ctcaccgcgt tggcgatctc ggcgccgtgg tccaggcgcc agatgtgcag ccccaggtcg
     2521 agcgaggccg cgctcccggc cgagctcagc aggtcgccct cgtccacgta cagcacgtcc
     2581 ggctccagcc gcaccttcgg atgcagctcc cggaacgcgt cggcccagcg ccaatgggtg
     2641 gtcgcccggc gcccgtcgag gaccccggcc tccgccaggg cgaaagtgcc ggtacagaag
     2701 ctcacgacac gtgccccgcg cgcgtgggcg caccggatgg cgtcgagcac tgcgggaccg
     2761 cgcggcacga cgttgtccgg acggcccggt acgacgaggg tgtccgcgtc gtcgacggcg
     2821 tcgagcccgg ccaccccggt catggtgaag aacccatggt tcatccggac ctcggattgg
     2881 ggcgtgcaca gcgtcacctc gtacagcggc cccgggagcc ccagctcggg ccgcggcagc
     2941 ccgaacaact cggtcgccac gccgacctcg aaggggttgg tggcttcgtc gacgacgatc
     3001 gcgacgcgat gcggaagcgg tggagagtgt tgcgaggatc ctttcggcat gtgcgattcc
     3061 tagcactcgt ccggtaatgc cgtcacccgc acgatgaccg tatggaatcc acggaaccca
     3121 ccgaacccat ctccctgttc gacgctctca cctccttcga cgccctgtgg agcccccgca
     3181 tcgtcaccac cgtcaacgac tacgacgtcc gcgtcgcgaa ggtcgagggc gaacatctct
     3241 ggcacaccca tgaccacacc gacgagttct tcctggtcat cgagggtgaa ctgcacatct
     3301 ccctgcgcga accgtccggc gagcgcacgg tcgtcctgcc ccagggttcg gtcttcaccg
     3361 tcccgcgagg caccgagcac aagccgtacg ccccggcccg cgccgccatc ctcgtcctgg
     3421 agcccaccgg caccctcacc gtgggcgacc gccacgacga gatcccggac cacgtggacg
     3481 cgacgacggg gcatgcgctg gcctgaacac cgggcctccg cgagttgtcc acaggcccgt
     3541 ccgcgaggtt ttccacaggc tcgcgagcgg gtggcgggcg agtggcactc tggacccatg
     3601 aacgacacca cgacccagca cccgacaccc cgccgtgtcc gtgtccgcgc ccccgagctg
     3661 atcggcaagg gcggctggct gaacacgggc gggaagcagt acaccctcgc tgacctgcgg
     3721 ggaaagatag tggtgctcga tttctggaca ttttgctgcg tgaactgcct gcacgtcctg
     3781 gacgagctgc gggagctgga ggagaagcac cgggacacgg tggtggtcat cggggtgcac
     3841 tcgccgaagt tcgcgcacga ggcggagcac cgggcggtgg tcgacgccgt ggagaggtac
     3901 gaggtggagc accccgtcct cgacgatccg gagctcgcga catggaagca gtacgcggta
     3961 cgggcctggc cgacgctcgt ggtgatcgac ccggaggggt atgtcgtcgc ccagcacgcg
     4021 ggcgaggggc atgcccacgc catcgagcgg ctggtggcgg agctggaggc cgagcacggg
     4081 gcgaagggca cgctacggcg cggcgacggg ccgtatgtgg cgccggatcc ggagccgacg
     4141 gtgctgcgtt ttcccggcaa ggcgctgctc ctcccggacg gcgacttcct ggtcagcgac
     4201 acgacccggc accagctggt ccggctggcg gcggacggcg agaccgtcgt acggcgctac
     4261 ggatccggtg agcgcggatt tgtggacggc accgccgagc acgcccgctt cagcgagccg
     4321 caggggctgg cgctgctgga caacgccacc gtggtcgtcg ccgacaccgt gaaccacgcc
     4381 ctgcgccgcc tcgacccggc caccggtgag gtctcgaccc tcgccggcag cggccgccag
     4441 tggtggcagg gggcgccgac ctcgggtctc gcgtgggagg tcgacctgtc ctcgccgtgg
     4501 gacgtggccg tcttcgccgg caaggtctgg atcgccatgg ccggtgtcca ccagctgtgg
     4561 acgtacgacc cggccgactg caccgtggcc gtggcggcgg gtacgacgaa cgaggggctc
     4621 gtggacgggc cgggggcgga cgcctggttc gcgcagccgt cggggctcgc ggccaccgcc
     4681 gaccggctgt ggctggccga ctccgagacg tccgcgctga gatgggtgga cctcgacggg
     4741 gtggtccaca cggcggtcgg caccgggctc ttcgacttcg ggcaccgtga cggcgcggcc
     4801 gaacaggcgc tgctccagca tccgttgggg gtcacggtcc tgcccgacgg ttcggtggcg
     4861 gtcagcgaca cgtacaacca cgcgctgcgg cgctatgacc cggcgacggg tgaggtgacc
     4921 acgcttgcca cggatctgcg ggagccgagc gacgcggtgc tcgtcgggga cgacatcgtg
     4981 gtcgtcgagt cggcgagaca ccggctcact cggctgcggc tgccggagga gaccgtgaag
     5041 gtcgaggccg tcgcccaccg cacgcagcgc gcggccaccg aagtcgcccc cggcagcctg
     5101 cggttggagg tcatcttcca ggccccgccc ggccagaagc tcgacgaacg gtacggcccg
     5161 tcgacccgtc tcctcgtctc cgcaaccccg cccgagctgc tgctccgggg cgagggcgcg
     5221 gacccggccc tgtcccgcac gctggagctc aacccgtcca tatccgaggg cgtactgcac
     5281 gtctcggcga tggcggcctc ctgcgacgac acggcgtcca acagcggctc cgccgcgggt
     5341 gccaacgagt acccggcctg ccacgtccac cagcaggact ggggcgtgcc ggtccggatc
     5401 acggacggcg gggcggaccg gctgccgctg gtactggcgg ggatggacga gagtctctag
     5461 gtccagtgcg tccttcaact gtccgaagtt gaacggcatt cgcctatagc ccgggatgcg
     5521 agcgcgcaac cgaaggcgga cgatggagtg gtcgggcgcg tattcccgca gtggagtgtg
     5581 gtgtggcagt ggacggctgg cgcgggggcc gtccacggtt ccctctctct cgccgcgtcc
     5641 cgctctcgcg gttctgttcc cctcgttctc gaacggccgt cgccgcccgg gacgttcact
     5701 cggtcatgtg ccgattccgg accggttcac ttcgtggagg cactcacatg cccgtgctct
     5761 tcttcgacat aggagcgacc ttggcggatg cccgggagga ggtggacggt tcgctgacgt
     5821 tggtgccccg gccccgcgtc ctcgccgtgc tcgacgcctt cggcgacgta cgcaagggcg
     5881 tcatctccaa cccgggcccg ggtgaaggcg ccgcggagcg ggccgcgtca gccctgcggg
     5941 aggcgttccc cggccggttc acggacgacg cgctcatcca ttggggcccc aagaacagcc
     6001 gggagatctt cgacgaggcg gtcgccggca cggcgggcga ggggatcccg gcctccgcgg
     6061 ccggcgaatg cgtcttcgtg ggtgaggacc accaggagcg cgcgttcgcc gggcaagccg
     6121 ggctgcgtac ggcggcccac cccgtgttca ccggcgccgc cctggagaac cgtcctgtcc
     6181 tctgggctcg gatcgagctg cccgaggacc gggggctgcc cgcactggag acggtcgcga
     6241 accggaccga ggtcgttccc gtgcacatcg cctccgcgcg gctcgtgctg gccatggcga
     6301 gcatgcgcgg cgccgcggca ctcgaacagg ccgggttcac ggtcgacctg cgggggccgg
     6361 tggaggacac ggcggccttc ctgatccgcg acgaccgccc cctcaccccc gcccagggct
     6421 tcgaggacgt cccggagagg gcgacgaccc gtgccacgtc cgctttcggc gtcgtagccg
     6481 acgaactcgc cggcctcacg gccccgccgc tcctcccact gggccccgcg ccgggcggtg
     6541 tctatgtcgc cgttcccgcc ggcgctccga tcgaggacgt ccacctgccg ggcgcgaagc
     6601 ccggccacac cgagcgactg cttccggatc cggcgctcct ctcccgcccc ggcgaggcat
     6661 gggcgcaagg actcgccgca ggccctacgg aacggatgga aggcgctacg gaagttccgg
     6721 cggagccggg ccgacccgcg tcggcagccg gtgacggccg cccttccccg gagacgatcg
     6781 ccgcggtacg ggcggccgtg accccccagg cactgcgcgg ccatgtcgcg cgcatctccg
     6841 gtgtcgaacc gctcagagac ggcgaggcgc tgctggtgcg cagtcgggac gcgtccgccg
     6901 cggacaaccc ccgagtcgtc gaggcgctcg cggaccgctt ccagaacctc ggcctggatg
     6961 tacgactgca ccggttccgg tggcgcggac gcccgttgtt caacgtggag gccgagcatc
     7021 gtgtggccgg ggcggactcc acggttctca tcacggcgca tctggactcc actgcctcca
     7081 acggcgcatt cgtcgacgag aacggcgacc cgcgccccta cgaccccacc gtggaccccg
     7141 caccgggcgc cgacgacgac ggcagcggaa ccgccgccgt catggccgcg gccgagtgcc
     7201 tgcaccactt gctcgcggag ggcaggacac cgacccggaa cgtgcgcttc gtgctcttca
     7261 acgccgagga acagggcctg gtcggcagca agttctacgc gcgggccgcc gccgcggcgg
     7321 acgaccgtat cgccggtgtg ttccagatgg acatgatcgc ggggcgtcag cagggcagca
     7381 cacccaccgt cgagatccac gccggttcct cggtgccggg tccggtcgtc gacgcatccg
     7441 acaggctggg cgctctcgtc gcggacaccg tccccgccgt cgaccccgcg gtgacggtcc
     7501 aacagctcat gggcccctcc gatcctgcga tcggacggag cgaccacgcc agcttccacg
     7561 agcgggggtg ggcggccatc gctgtctccg aggacatctt cgctccggac ggcgggcccg
     7621 gtacgggcac caggcagtac cacacaccgg gagacaccct catcgaccgg gatcacagcc
     7681 cggagttcgc ggccacggtc gcccgctccg tcacggcgac cgcgctcact ctggccggcc
     7741 tgtaaccccc gacacgtaac ccccgacacg taaccccgac acgtaacccc cgacacacgg
     7801 gcctccaccc cacgagacag ccgaaacagg acagccgaag ccgggcctcg cacccggcga
     7861 caggagcaac cgtcatgaca cagctgatcg acaagcggga tctgcagtac gaccggctcg
     7921 cccgggtccg gggcgccgaa gcgttcctcg cccagaccga tcgtgtggcg gagtcggtgc
     7981 accacaccct catcgccgac gacagcaagg tgaaccgctt caccgggcac ctgaccgagc
     8041 tgcgggtgga gggcgcaccg gccgacctcg ccgaacgggc gggcgccgag gccgccgacg
     8101 gcgactacat cgtccgcgcc aaggagtacc tttcctcggt ctcggaggcg atcggcttcg
     8161 ccgccggaga gcccgccgag ttcgaggccg atccgaaggt gacgtccacg agcggcggca
     8221 tgcgcgtggt cagcctccag cagacactca acggcatcga cgtgtggggc atggctccca
     8281 aggtgtggct gcgccaggac ggcacggtcg acagagtcgt cggcgacacg gcgagcgtgc
     8341 cgagcaatgt gcccacgatg ccggcggtgc cggtcgagac ggctctggcc gccggcgccg
     8401 cgaaggccgc cgaaccggtc acgatcgacg gcctcttcgg caccgacgaa ctgccggctc
     8461 tggacctctc ggaaggcctc cgccgactga gctcccaggc acgcaacgac cagccgatga
     8521 cgttcgacaa aggcgccttc gacgaggcga tccccgcgcg gctcgtgtac ttctacatgg
     8581 gcgacaccgt ccgactcgcc tggtcgttca ggttctcgcg cgcgaaggga gccgtgcagt
     8641 accacgcgct cgtggaggcc gacgagagaa cgccggacaa ggccgcgccc caggtcctct
     8701 acctccagga cctgacgaac catgtcgtcg gaggactggt gttccggcag aacccggccg
     8761 agaccgggta cgccctggct tccttcccgc taccgctgag cgactatccg gtcgaaccgc
     8821 cgcccgaacc gctgcccggg ttccccgggc catgggccga gcggcagaac gggcaggtgg
     8881 cgaccgcggg gaacaacgtg cacgccgtcg acggggacac cggtgaaagc ttcaaggtcg
     8941 gcgtcgacac gtcgggcaac ggggtgttcg ccccgaaccc ggacacaccc gagcaactcg
     9001 tcaccaacat cttcttcttc tgcaactaca tgcacgactt cttcgtgatg ctcgacttca
     9061 cggaggagca cggcaacttc cagaccgtca atttctcggg cctgggccac ggcgccgacc
     9121 cggtcgtcgc cctcgcgcat cccggcccgg tcttcgggac ggccaacatg ctcacgcccc
     9181 ccgacggtcg ggcggcggag atgaacatgg ggctggtcgc cggcaccgga cggcacacgg
     9241 ccaacgacgc acacgtcgtc ttccacgagt tcacgcacgg tgtgaccaac cggctggtcg
     9301 gcggcctgca tgatgccaac ggtctgcgcg aggaccagtc ccgggcgatg ggcgagggct
     9361 ggtcggacta cttcgcactc accatcccca acttcttccg ggagcgggag cacatcgtcg
     9421 tcggcgcctg ggtcgtcgac gacccgggcg gcatccgcca gcggccgtac gacgaccgct
     9481 accccggtgg cttcggggac atcgggcagg ccaagggcgg gctcgactac acgaggatcc
     9541 acaatgtcgg cgagatctgg tgcgccgcgc tcatggagat gacccgccgg atcagcgcgg
     9601 aactcggcag caaggagcgc ggctaccggg tcgcctggca ggccgtcgtc gacgggctga
     9661 aacttacccc gaagaacccg tcgttcctca ccgcccgtgg cgcgatcctg cgggccctga
     9721 aggacctcaa gggcacggcg ttcaccgagg ccgagtaccc cgaggtccgc aaggcggcct
     9781 ggggttcctt cgcccgctac ggcatgggct tcgacgcctt ctgccccaac gcgtccttct
     9841 tcggctgccg ggccggtatc cagctgcccc cggccggaca cgaggactga ggcccccggc
     9901 cggacacgag gactgaggcg gtctgtcgga cacgaggact gaggcggtct gtcggacacg
     9961 aggactgagg cggtctgtcg gacacgagga ccgaggcggt tcagctgtcc cgctccacca
    10021 tgtagtacgg caggtcgagc aggaactgct tgtcctcgga gtcgggattg tcgtcgaacg
    10081 ccttgagcgc ctccctgtga gcctcgtcgg cgagggccct cgccctcgcc cgtacggtct
    10141 cgacgcagcc cgacgcgagc agttcgtcgc gtacccaccg cacctcgtcc tcggtgcggg
    10201 cggcacgggt cctgcccagg aagcgctcca tccgcgcccg ctgggcggcg gtacagcggc
    10261 gcatgtattc gatgaggacg agcgtgcgct tgccctcccg gagatccccg gagatctcct
    10321 tgccgtaccg cgagtagtgg ccggtcaggt tgagcaggtc gtcctggatc tggaacgcgg
    10381 caccgaggta gcagccgtag cggtcgaaac gggccgtcgc cctgtgcttg ccctcggcca
    10441 cgagggcgcc gacgcgacaa gggtggatac acgtgtacca ggacgacttc ttcatgcaca
    10501 tccggtagta gtcgtcgtcg accaggtcgc aggcgttgtt ccggatccag ccgacttcga
    10561 tcgcctgccc ttccagcgaa tggcgcatca tcagcgcgga ttcctggagg atcgcccacg
    10621 cgaggttggg tccgagtgcc caccggttgg ccatcaggtg ctgcagcgcc agaagattgg
    10681 tcgcgctgcc gacgttgacc gcgaccccga ggccgtactc ggcgggcagc gtcggcgccc
    10741 cgcggcgcat ctcgctgccg tcctgtacgt cgtcgaggat gaggaacgcg ttgtgggtga
    10801 gctcgatggc gaccgccgag tcgatcgcct tctcgatgtc gccgccgagc gcccgacaca
    10861 ccgccaggca cagcgccggg cgcagaccct tgccggatcg gctggggtag tcgcgcacga
    10921 ggctgtacag ctcgtcctcc gccgagtccg gaatgtccga cagcagccgc gccatcgtga
    10981 ggtcgcggta gcgcgtgaga acggattcca cggctgaggg gccgaggccc acgcccggtt
    11041 cggcggtcat ggatcggccc ccctcaggcg ctggggcgcg gtggttcgtc accggaatcc
    11101 gacgccggcg tgtcgccgtc gtcggtgagc ggcgtggggc ccgcgggtgg cggcgtggtg
    11161 aagcccaggt tcgccagggt cctggcggtc gcgggcgtgt tctcgacgag gttcatcgtg
    11221 gtgtcgacca cgtcgtgcgc gtcggtggcc atccgcgaca ccagcgactg gacctcgttg
    11281 gtcttgagtt cggagaacat ctcggcggcc atcgcgatga ggtcgtgcac gtccttgcgg
    11341 acccggctgc tcaacagctg gaactcgttg gggtcgacct tcttcgttgt cgcgtacttc
    11401 ttctgcatgg ccgtggcgcg acccgagccg tcggtcagct cctgctggag aatcgtcgct
    11461 gcctgcttga ccacctgaga gaccgcgcga gacagctcaa ggcgctccgg gtcgactcgg
    11521 ttgaggtgct cgtcgggcat gcgatctcct cacgcagaga aatgtactaa ttatggtgat
    11581 atgcgtgatc gtaatggaga ccgtcggtga gcccgtgcag caaaccgccg tgatcaacct
    11641 cagtacccct ggtagccgtc gcggtgatgg cggtgccggt catcgtcgat gacgggcgtc
    11701 gcgggcggca ccacgacgcg cctccgcctg gcgatgctgc tgaacgtcgc gactccgatg
    11761 agtccgacga tcatgaagat gacgccgacc aggtcgaggt tgaccccttg catgtcccag
    11821 tcggtggcga acgtgaggat ggcccccacg gcgatcagaa tgatgcaccc gcccaggccc
    11881 atgagtgttc cctcccagtc cggttgggtc ggccggtcgt tccggtcgtt cggtccttcc
    11941 ggtcggttcc gggtacccgg acggggctgt ccgtaactgg gcgacagggg cccagcccat
    12001 gggaccagcc gcgggcctag ccctccagga acgccgccag cgcgttcgcc aggaggtacg
    12061 ggtccttggc gccgcacagt tcgcgggcgc tgtgcatgga gaggatggcg acgccgatgt
    12121 cgacggtacg gatgccgtgc cgggcggcgg tgatcgggcc gatggtggtg ccgcagggca
    12181 tggagttgtt ggagacgaag gtctgcaagg gcacgccggc ccgctcgcag gcggcggcga
    12241 agatcgcgcg gcccgaaccg tccgtggcat agcggttgtt gacgttgacc ttgaggatcg
    12301 ggccttcgtc ggcgcggggg tggtgcgtcg ggtcgtggcg ctccgcgtag ttggggtgga
    12361 cggcgtgacc ggtgtccgag gagaggcaga ccgtaccggc gaaggcgcgc gcccggtcct
    12421 cgtacgagcc gccgcgggcg aataccgagc gctccagtac gccgccgagg agcggcccgt
    12481 cggcgccggt gtcgctctgc gagccgttct cctcgtggtc gaaggcggcg aggacgggga
    12541 tgtgggggag ttcgtcgccg gaggtggcga cggcggcgag cgcggccgta ccggcgtgca
    12601 cggagaggag gttgtccatg cggggaccgg cgaggagttc cttgtcgcgt cccaggtacg
    12661 cgggcggttc gacggagtgg gtcatcaggt cccagccggt gacctcgccc ttggggaggc
    12721 ccgactcctc ctccaggaag gcgatcaggt cgccgtcgcg gacgtcgtcg cccaggcccc
    12781 agatgggctg gaggtgacgc tgcttgtcga gtttgaggcc ctcggagctg accgtgcggt
    12841 cgaggtggat ggccagttgg gggacgcgga ggaggggcct gtcgatgttg accaggcggc
    12901 tggtgccgtc acgcagggag agacggccgg cgaggccgag gtcgcggtcc agccaggagt
    12961 tgagcagcgg gccgccgtag atctcgacgg agacctggcg ccagccgtgc gctgcgctgt
    13021 ccgggcgggg tttgacgcgc aggttggggg agtcggtgtg ggcgccgaca atgcggaacg
    13081 gggtgtgcgg ggtggcgccc tccggcacgt accaggcgat gatcgcgccg ccgcgcagca
    13141 cgtacttgcc gcccagggtg ccgtcccatg cgtcggtctc cgagacctgt cggaagccgg
    13201 ccttctccag ccgttccgcg gcgctcgcca ccgcgtggta cggggacggg ctggccgcca
    13261 ggaaggtcat gaggtcgtcg gtgtggccgc gatcgaagcg tgggggtgtg cgcatggggt
    13321 tcaccttaac gacgtacgag ggcccgctcc gggggttggg aactgctcgc cgggcagcat
    13381 gcgggaggtc gtgttggctc gctcgtgtga tgggccgttc ccgggcttgt ggggggctgg
    13441 gccgttcggg ctacggtgag cgtgcgatct gggacgccgg gtatggcgtc ggcgtgcggg
    13501 gcccccgctc caccggagtg atggttcggg gcctccccgt cgcctctggc cttatccata
    13561 tgcccaggtt gtgagggcag cgttcatcag cggcctccgg ccgcggagac ctcctgggat
    13621 cggaccacgg acaggatccg tgtcgccgcc ccggggtcga gcatgccggg gaccagctcg
    13681 cccaagaccg ttcggggcgc gcggctgagc ggactcactt ctgctcagtc ttcaggaacg
    13741 gttgggagcg ggtcctcgcc cgcaggtggg acaggtgggt gggcagccgg cccggcggcg
    13801 cggctgcccc cagcttcagc cagcggctgt tagaacgccg cctcgtccag ttccatcagg
    13861 tccaggtcga cggtctcgga gatcttgcgg gccagggtga cgcccgggag gacgttggcg
    13921 gcgaagaact tcgcggccgc gatcttgccg gtgtagaacg ccttgtcctt ggcggaggcg
    13981 ttcggcagct tctcggcggc gaccgcggca cccttgagca gcaggtagcc gacgatgacg
    14041 tcaccggagg ccagcagcag acgcgtggtg ttcaggccca ctttgtagat gttcttgacg
    14101 tcctgctcgg tggcggcgag gtcggtcagc atcaggccga cgatggcctc cagctcgacc
    14161 gcggccttgg cgaggtgctc acgggcaccg gccagctgct cgccgccctc accgagcgcc
    14221 aggaacttct tgatctcctc ggcgagggag ttcagtgcgg ctccctggtt gcggacgatc
    14281 ttccggaaga agaagtcctg gccctggatc gccgtggtgc cctcgtacag ggtgtcgatc
    14341 ttggcgtcgc ggatgtactg ctcgatcggg tactcctgca ggaagccgga gccgccgaag
    14401 gtctgcagcg actgggcgag ctgctcgtag cccttctcgg agccgtagcc cttgacgatg
    14461 ggcaggagca ggtcgttcag cgcgtgcagg gccgagacgt cctcgcccgc cgcctccttg
    14521 accgcgatct cgtcctggat ggacgcggtg tagaggacga gcgcgcgcat gccctccgcg
    14581 tacgccttct gcgtcatcag cgagcggcgg acgtcggggt ggtgcgtgat ggtgaccttg
    14641 ggcgcggtct tgtccatgaa tttggcgaga tcgggaccct ggacgcgctc cttggcgtac
    14701 tccagcgcgt tcaggtaacc ggtcgacagc gtcgagatcg ccttcgtacc gaccatcatc
    14761 cgggcgaact cgatgatccg gaacatctgg cggatgccgt cgtgcttgtc tccgatcagc
    14821 cagcccttgg ccgggtggcg gtcgccgaag gtcatctcgc aggtgttgga ggccttcagg
    14881 cccatcttgt gctcgacgtt ggtggcgtag acgccgttgc gctcgcccag ctcgccggtc
    14941 tcgaagtcga agaggtactt cgggacgagg aagagggaca ggcccttggt gccggggccg
    15001 tggccttcgg ggcgggcgag gacgtagtgg aggatgttct cctccatgtc gtgctcaccg
    15061 gaggtgatga accgcttcac gccctcgatg tgccaggagc cgtcctcctg ctgcaccgcc
    15121 ttcgtacggc cggcacccac atccgaaccc gcgtcgggct cggtgaggac catggtcgaa
    15181 ccccaggtcc gctcgaccgc gatctgggcg atcttcttct gtacgtcgtt gccctcgtcg
    15241 tagaggatcc cggcgaacgc cgggccggag gagtacatcc acacggccgg gttggcgccg
    15301 aggatcagct ccgcgaacga ccagatcagg gaggcgggag cggtcgtacc gccgatgccc
    15361 tcgggcaggc cgaggcgcca gtactccgac tccatgaacg ctttgtagct cttcttgaag
    15421 gaggccggga ccggagcggt gttcgtctcc gggtcgaaga ccggcgggtt gcggtcggcg
    15481 tccgtgaagg actccgccag ctcgttctcg gcgaggcggg tcagctcctc caggatgctc
    15541 ttggccgtgt ccgtgtccat ctccgcgaac ggaccggtgc cgtacagctt gtcgcgcccg
    15601 aggacctcga agaggttgaa ctcgatgtcg cggaggttcg acttgtagtg ccccatggcg
    15661 atggctccgt agagagatcg gcgaggcact ggatcctcgc gctagttcac ataccaacaa
    15721 gtagcttcga tgtcgatgat gctacccatc ggtaataaga agcaaccccg atcgggtcat
    15781 ctgtgactcg ttacgctttg ccgcatgtac ggctacgacc agagcgctgg cactcagcag
    15841 cagtacgccc cgccaccgca gcagcagatg ccgggccagc agatgcccgg cggcccgatg
    15901 ggcggcgggt acgggcagca gccaccgctg taccccgagc cgtcaccgcc ctcgctcgcg
    15961 gacgcggtgc gcgccttcac caccggtcag atggccgccg aggacttcca gcaggtcttc
    16021 gcgacgtcga aggtgtactg cccgcgcggc gacaatcccg ggttcctggc cctgcacaac
    16081 acccagcagc cggtgatccc gatgttcacc tcgctcaagg agctccgccg ctacgccggc
    16141 aaggagtcca agtacttcgt catcaccggc gctgaggtga tcgacctgct gccgaccggc
    16201 tatggcttcg tcctcgacat ggagggcgag caccgcatgg tcttcgacgc gaaggccgtg
    16261 gaacagatgg tggagttcgc gatgcggcgg atgtacgggt agctccgctg gttgggccgg
    16321 gtccggattc ggcccggtgg gctgcggttt gctgcggggt gcgggttgtg tgtggggctc
    16381 gcgcagttcc ccgcgcccct ttgcttggct gccgtgggcc ctcacggctt tactgaactg
    16441 tttcttccgt tcattgggtg gcctactgtg ccccggtgac cgagatcgac acctcgccgc
    16501 tggtcctgta tggccggcgg cgttctgttg cccgactgaa ggccggcgtg ctgttgctgg
    16561 accaggggcg gatccgtcgc cgtatccccg tctcggcgat cgaacgggtg gacgtgggcg
    16621 gccctcgggc gtgtgaactg acggtcgtcc tgaccgccgg gaccccgccc gccgtgacgt
    16681 atgttctgcg ggcacgcagc gccccgatgg tccgggagtt cgcggcggcc gtgagccggg
    16741 cgctgcccgt gcgggatgcc gaggagccgc gtcacgacgg ggcggggctg gtgtcggagg
    16801 aggtggtcaa gcggtggtcg ccgagtccgg cgcactgggt ggcgacgggc ctgctgatcg
    16861 tctatctgtt ggtgccactc attctctggg tcgccggaag gacgacaccc ttcgtcctgt
    16921 ggctgctggg cccctgggtg gccctgctcg gactggggag cgtgatgggt ggctgggagg
    16981 cgaaggagaa ggccgccgcg ctgcgcaccc gggggatcac ggtggaggga cgactggagt
    17041 actcgtacga ggaacgctcc ggggaggaca ccgtcaagaa gtacgtctac tccttcgccg
    17101 acacgagcgg tgaggtccat cagcgccatg gcacgcaggg cggcggtgcc gagcgggtcg
    17161 agatcgtcta cgaccccgcg gacccgaagg agaacaacaa ggtcggacgc ggtacggcgg
    17221 tgcggctggc aggggcatgg ctgctcgtcc tgctcgtcgg ggtcccggcg gtggtggccg
    17281 gggcggcgtt catggtcgtg ggcgtggtgg ccctgtgccc ctgggccggg gcggaatgag
    17341 gcccacggcg gaaagcggaa tgaagcccca tggcgaagac gggaatgcga cgcgggtcgt
    17401 gcgctgttga ggctggcgga aagttcaaca atcaactaaa gtgagcgtac gacgaggagg
    17461 taccgacatg cccgcagtga ccgtcgagaa cccgctggcc ctgccccgag tggtggcgcc
    17521 ggccgacgcg gtggcccgtc ccgtgctcgg tgtgacaacc gcgcccagtg gcttcgaggg
    17581 tgagggtttc ccggttcgcc gcgcgttcgc cgggatccac taccgccacc tggacccgtt
    17641 catcatgatg gaccagatgg gtgaggtgga gtacgcgccg ggagagccga agggcacgcc
    17701 ctggcacccc caccgcggct tcgagaccgt gacctacatc atcgacggga tcttcgacca
    17761 ccaggacagc cagggcggtg gcgggaccat caccaacggc gacacccagt ggatgacggc
    17821 cggttccggc ctgctccaca tcgaggcgcc gccggagtcc ctcgtcatgt ccggcgggct
    17881 cttccacggc atccagctct gggtgaacct cccggccaag gacaagatga tggcccccag
    17941 gtaccaggac atccgcggcg gccaggtcca gctcctcacc acccccgacg gcggcgcgct
    18001 cctccgcgtc atcgccggtg agctggacgg ccaccagggg ccgggcatca cccacacgcc
    18061 gatcaccctg ctccacgcga ccgtgacgcc gggcgcggag atcacgctgc cgtggcgcga
    18121 ggacttcaac gccctcgcgt acgtcctcgc cgggcgcggc actgtcggtg cggaccggcg
    18181 gccgatccac atgggacaga cggcggtctt cggcgcgggc tcctcgatca ccttccgcgc
    18241 ggacgagaag caggactcca acgcgcccga cctggagatc gtgctgctgg gcggagagcc
    18301 gatccgtgag cccatggccc actacgggcc gttcgtcatg aacacccgcg aggagctgca
    18361 gcaggcgttc gaggacttcc agaagggccg gctcgggacg atcccggcgg tccacgggat
    18421 ggccgagggc ggtatctgag cctgagcgag ccgaggctcc tgccggacca tgggcggggg
    18481 cctcttcgct tccggcgggt gcttgagtcc ggtacggtgc gacgaggccc gaagccgcaa
    18541 cttggatttg cgacttcggg cctgtcttac gagggctgca ctgcgaggta gtgcggggtt
    18601 ctacgggtta cggcagcacg tacaccggtg ccccgtcctc ggtgcagccc ctctgccgta
    18661 cgcatccccg cttcagcagc atccgcaggc agtcgttgac gcgctcctgc gacagccccg
    18721 tacgagtgga gatctcctcc aggcgatagc gggcctcacc gcgcaccagc gccggggcga
    18781 gacaggccgc gaccgcgtgg acatcctcgg tgacgaccag gttcttcgcc ttccaggtgg
    18841 cgagcaggtc ctggggggtg agttccggtt ctggttccgg ggtcgagtgg gagcggttgg
    18901 ggcgtctgag ggactcggcg atgtcctgga gggcgtcggc gatcctgctc tggctctggt
    18961 tgagctgctg cagcagatgg ttgcggtcct ccgtgaaggc cgcgagcatc tcgtccgcct
    19021 ccaggttgcg ttgttcgagt cgcacgatcg cgtcggcgac ttattggggc atgacgtagg
    19081 ccggggggcc gacggcgggg gtttggacgg gggagggttc gagggcgtag gagccgtcgc
    19141 gctggatggt ggtgatgacg tcggagaccc acgccttgaa gggtgcgcat tccggcttgg
    19201 tgcacccgtt gacgagcgcg acgaggccgc gcaggttcac catcttcatt gacttttgca
    19261 gcctgtgatc tgcaagtttg cgtgaggtgt ctactgtata gacgccttgt gcaatctcac
    19321 tcagaggctt cgtgcaatct ggcgcaacgt gccagccgag agcctgacgc gtgtttgcgt
    19381 agccgagatt cgaggccacg tcggccgcca cgaaccagtg ctccccgtcc ggggtcgtaa
    19441 gcctccgcat gcgcgccccg tggccgcgaa cacgaagtcg ttgatgtcga tggcgtccgg
    19501 tcgccgtgcc gccgattcgt cgggcggcgt gttgttctgc tcgtacatcg agcatcacct
    19561 ccgcctcgga cgctaggcag agggcggaac aactcgcggg catagcaagg atgttcaccc
    19621 tatagtggac agcggtatcg attctgtgac aaagggggag aggggcaggt cccctccgcc
    19681 tgcccctctc cccctttgtc gctcggccga acgtcaaagc ctgctgttgt cgcccttgtt
    19741 gacgatggtg gccttctcgc agttcttcca ggtgagtttg ttggggcccg ctccgtgtcg
    19801 cgccactcgc tgaacatggc gtacgtgccc gacttggtga aggtgttgcc gctcaccgtg
    19861 ttgtcgctgc tgcggtcccg gatgcgtacg gggtcgccgg agacgccccg ggtacttcgc
    19921 ggccacgtcc ggcgccgacc agctcggctc ggccagggca cccaggatca gcgcgctgcc
    19981 gaccgcggtg gtgacgaagg ccttcggtac ggaacgggta cgcggggcgt gcgtacgcat
    20041 ggggcaactc ctcatcaggt tggtcgggtg ggtggggtgc ggccgggcct cccccgtggg
    20101 gccggccgtc gcgacagcaa ccgagcctgg gccgtgggat cttgtccggc aatggctttc
    20161 cgtgtccggg acagacgggc cgctgtccgg gctggtcggc ggctggtcgg cggctggtcg
    20221 gcgggctggt cggcggcttg tccgggcggt acgggcggtg cggctggggg cgcccgacgt
    20281 ggccgggacg agggttgtcg gccgcgacgg ccgggatcac aatgaccgca tggcgatcac
    20341 gggggacggc gagaacgccg acaacagtca caacagcgac aacagcgaac gcagtggaaa
    20401 caccgggggg ttagaaccgg gcggcgcacg caccgcagcg gagtacgtcg tcctgttgcg
    20461 gcggctcaag gagcacagcg ggttcacctt ccggcagttg gagcagaagg ccgccgagcg
    20521 gggtgacgtc ctggcccgca gcaccctcgc ggacgtactg cgacgcgacg cgctgccccg
    20581 cgcggaagtc gtcgccgcgc tcgtccgggc gtgcggggcc gggagggacg agtccgcgtg
    20641 gctggcggcc agggagcgga tcgcgtccat gggtggggcc gagggcgagt cttcggattc
    20701 acctgattca cctgattcac cggattctcc ggactccccc gtgtcgtcct ccggcagctc
    20761 cgacgcctcc ggcagccgta tccgtaccgc ctccctcgcc accgtggcct cgctcgggac
    20821 ggtcgctctg ctcgtcatcg gcgcggtggt gctgttgccg caggacgggg aggcgccggc
    20881 caccgagggt gcgggcggcc aggcgtcgga gacgtccacc ccggtaggac ccggccccgc
    20941 ccccggactg tcccgcattc gcccggtgcg cgcccccgaa ctgtgcctga ccgaggggga
    21001 ggcgcgcgtc gagagcggtg cgtccaaggt cgtggcggta cagcggccgt
//
