LOCUS       NZ_CP022161            11341 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7351463
            Orig. end                         :: 7362804
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11341
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="31"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11341
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11341
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6341](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6341)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(493..1431)
                     /locus_tag="CES90_RS32850"
     CDS             complement(493..1431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009324628.1"
                     /locus_tag="CES90_RS32850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_189780489.1"
                     /transl_table=11
                     /translation="MAETHARRSRRPAGALAALFLAAALALTGCGANGDSSGGTTASDS
                     KADMSGRQEGALNGDSGSAQSSGEAADAPIKVAPSHIIRTASLTVRVKDVPKALDEART
                     VAENAGGFVADESTTRDGKDRERTRVVLRVPTEKYEEVLGELEGTGKLIERKTKAEDVT
                     EQVVDVESRIKTQQASVARIRELMDRATKLSDVVTLEGELSTRQADLEALLAQQESLKD
                     RTSLATITLSLSETAVKKSDKDDDPGFVDALAGGWNAFVAVFRWLAMALAAVFPFAVAT
                     ALVLLLWFRLTRTRRPRPAAATPDESESEES"
     gene            1603..3057
                     /gene="hemG"
                     /locus_tag="CES90_RS32855"
     CDS             1603..3057
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000068: Oxidation (60% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981981.1"
                     /locus_tag="CES90_RS32855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_189780488.1"
                     /sec_met_domain="DAO (E-value: 1.1e-09, bitscore: 37.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGSRTGAGHAVVIGAGIAGLAAAHGLLDQGVRVTVLEASDRVGG
                     KLLPGEIAGARVDFGAESMLARRPEAVALARAVGLADRLQPPATATASLWTRGALRPMP
                     KGHVMGVPGTASALSGVLSDEGLARIERDADLPRTEVGDDVAVGEYVAARLGREVVDRL
                     VEPLLGGVYAGDAYRISMRSAVPQLFQAARTRTSLTEAVREIQARAAADRQTGPVFMGI
                     EGGVGQLPLAVAESVSSRGAEILTRTPVTELRREADGGWRLSTGDRVLHADAVVVAVPA
                     PAAADLLRAEAPEAAAELAAVEYASMALVTLAYRRADITLPEGSGFLVPPVDGRTIKAS
                     TFASQKWAWIADQNPDLLLLRTSVGRYGETEILQRDDAHLVDVSRNDLRAATGLDATPL
                     ETRVTRWDNGLPQYPVGHHARVARVREHIGKLPGLAVCGAAYDGVGIPACIASAAAAVD
                     QIHGDLRAVQDLTANPVQSLHGGAGE"
     gene            3062..3793
                     /gene="hemQ"
                     /locus_tag="CES90_RS32860"
     CDS             3062..3793
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564417.1"
                     /locus_tag="CES90_RS32860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_189780487.1"
                     /transl_table=11
                     /translation="MSDDAPTTESGRIPNKGKLAKDLNEVIRYTLWSVFKLKDVLPEDR
                     AGYADEVQELFDQLAAKDVTIRGTYDVSGLRADADLMIWWHAETSDQLQEAYNLFRRTR
                     LGRALTPVWSNMALHRPAEFNRSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGKMARGFPDVRANTVASFSLGDYEWLLAFEADELYRIVDLMRHLRASEARMHVR
                     EEVPFYTGRRKSVAELVAGLA"
     gene            complement(3910..4698)
                     /locus_tag="CES90_RS32865"
     CDS             complement(3910..4698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983659.1"
                     /locus_tag="CES90_RS32865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_189780486.1"
                     /transl_table=11
                     /translation="MRSTHHSGRLVSGTGLIVAGLTATLVAMVFPIWSYADRSGTGVAT
                     LNASTVSTQYGPLSALDRDFITKVRLAGLWELPAGQQAQTKGTTEAVRTAGNHLVEGHT
                     HLDARVRDVAARIGLPLPNQPSDQQKAWLETLSAAQGETYDREFANILRLAHGKVFSVV
                     AQVRATTRNSLVRDLADAANTTVLDHIRVLEATGLVDYDAIAREAASASAPPITNSPAP
                     PAPLNDPASPIPVTPSPTAPSPTPSSADYSLPPAAQGPRG"
     gene            complement(5001..6341)
                     /locus_tag="CES90_RS32870"
     CDS             complement(5001..6341)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009317893.1"
                     /locus_tag="CES90_RS32870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_189780485.1"
                     /sec_met_domain="DUF692 (E-value: 1.5e-95, bitscore: 318.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQIRQLGAGIGWRPEIADAVEGMAGPSGRVDWVEVVAENVCPGH
                     IPESLLRLRERGVTVVPHGVSLGLGGADRPDEQRLRDLAERAEVLGAPLVTEHIAFVRA
                     GGALTASPRLEAGHLLPVPRTRDALDVLCENVRIAQEALPVPLALENIAALINWPGEEM
                     TEGQFLYDLVDRTGVRLLIDVANLHTNHVNRGEDPAKALDELPVEAIAYVHVAGGFERD
                     GVWHDSHAHPVPQQVLDILADLASRVTPPGVLLERDENFPEPGELERELGAIRGVLEKA
                     EVRGPEEKAAPSAEAEAEAAEEAGEAEPAARQRLGLAQAALLSALVGGTPVPEGFDRVR
                     LGVQARALAAKRADVVGKVAPELPEILGKVYRPAFLAYAQGHPMTDGYRRDALSFAEHV
                     LLEQGLEDATAKRALRTWWLERSGPAPLSRRPAARLARATRRVLLRR"
     gene            complement(6522..7331)
                     /locus_tag="CES90_RS32875"
     CDS             complement(6522..7331)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481896.1"
                     /locus_tag="CES90_RS32875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_189780484.1"
                     /transl_table=11
                     /translation="MRRSKGSVLVAVAVVGTISAVAYPVFYSYPNRNAAAAAAVPTGDT
                     VTTQWGPLTPADRDLLIRVRLAGLWELPAGQQALERSGSKSVREAADHLIVGHADLDKR
                     SRVIAAKLGVELPNQPTAQQQGWLDQMTAAKTEAEYNKTWANLLRAAHGKIFPAIATVR
                     NSTRNTLIRQLASDANQTVLDHITVLEGTGEVDFETIANNSVSGTASPTGPPPPVPGQV
                     PPAAPAAEPSTNPRVSSVPSPTTPGLVPTGRPDPEELNKEQGEPVVP"
     gene            complement(7460..8068)
                     /locus_tag="CES90_RS32880"
     CDS             complement(7460..8068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481898.1"
                     /locus_tag="CES90_RS32880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_189780483.1"
                     /transl_table=11
                     /translation="MQRLNGSVIASLALVVTVGALAFPVWSYADRSGTAQANMASGMVN
                     TQWGPLTASDRDLIVRVRLAGLWELPAAEQAMQRSDSPAVREAADHLIVGHKDLDERVR
                     NVASQLGVELPNVPNAQQQAWLQQMNNATDDQYDRVWANLLRSAHGKIFPAIGQVRNGT
                     QNTLVRQLASDTNQTVLDHITMLEKTGEVDFDAIANGTI"
     misc_feature    complement(8020..8034)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    8154..8169
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            8347..8769
                     /locus_tag="CES90_RS32885"
     CDS             8347..8769
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS32885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189780482.1"
                     /transl_table=11
                     /translation="MKKAIPLKRMTAAATAGSALLTAGLLAAGPAQAATPETNSPVSAL
                     ACVVDLDPPTRGGAGVTALIRTSGCSQGVKWTAKLQSSRWWGWADDAEQTWNGSQSRRL
                     TAGCAGVHDHRVIVQAVVDGQGSPWKVGPKATLNCG"
     gene            complement(8840..9559)
                     /locus_tag="CES90_RS32890"
     CDS             complement(8840..9559)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009317873.1"
                     /locus_tag="CES90_RS32890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_189780481.1"
                     /transl_table=11
                     /translation="MSTGDPNSQDSPFRHERTSRDEAPQFVLPLVVHIEKASPPARTDA
                     LETAARAVLVMLSDERSVGAGEWAEAMRDWQDARIRKVVRRARGAEWRRAEALPGITVT
                     GKSAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPESPAEPDLSAPVIWMSPDLDMSAGK
                     AMAQAGHGAQLAWWALSEEARTAWHDAGFPLAVRTATPADWPGLTASGLPLVRDAGFTE
                     IAPGSCTVVADHPALRG"
     misc_feature    9578..9592
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.75"
                     /tool="antismash"
     gene            9641..10567
                     /locus_tag="CES90_RS32895"
     CDS             9641..10567
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009317912.1"
                     /locus_tag="CES90_RS32895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_189780480.1"
                     /transl_table=11
                     /translation="MGRELLLSLEGVGRRYGFRGPWILRGVDLAVAPGALIRVEGANGT
                     GKSTLLRVLAGIDAPTEGRMAGRPRTAYVPERFPAALPFTAAEYLTHLGAVHGLDRPAA
                     ARAADDWLERFGAAEYARTPMAQLSKGSSQKVAVAQALLAEPELLVLDEAWTGLDADAR
                     EELERVVVERTAAGAAVVFVDHDPRRLAGVPDATYAVAGGALNLRTGAGTSEGVGEGPA
                     VVVEARGPSRAQVPDEVVKLAADVEETGAGSHRFSVPEAGSDALLRALLRARPPWHVVS
                     VGPGKAMAEPEEESEPEVTGELEVERS"
     misc_feature    9653..9655
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10567..11238
                     /locus_tag="CES90_RS32900"
     CDS             10567..11238
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997023.1"
                     /locus_tag="CES90_RS32900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter"
                     /protein_id="WP_189780479.1"
                     /transl_table=11
                     /translation="MTALLRYQAALLLRSQRWLPPVILYAAFLAIGVQSGQPVLDSLGY
                     TAAALLPVAAWLVRICATNEPPAARSCTGAAAGPGRAHLACLLVALSAAVLLGAAATAF
                     VTIISAPTSTDHQTRIEAVPAAGAGLLAALVCALLGAAVGTLTNWPLLRSPGQAVPALL
                     LGALLALVLAGSPARAAVTSLVEGSQHATVPVPVLPLVAAALLTAVAIAVACALTTRRS
                     P"
ORIGIN
        1 ccagggtctg cacgccgtgc acaccgggcg cgtccacgcc ggacagggac gggcggatcg
       61 ggcgggcgcc ggtcgcgatc acgagtttgt cgtacgaggt ccaggactcc acgccggaat
      121 cgacgtcccg cgcgcgtacg cgcgcaccct cgacatcgat ctccacgacc tccgtacgca
      181 tccggagatc gatgtcgcgg gcccggtgct cctcgggcga gcgggcgatg agccggtccc
      241 gctcggggac gtcgccgccg acccagtacg gaatcccgca cgcggagtag gaggagaagt
      301 ggccgcgctc gaacgccacg atctccaact cgtcagggcc ccgtagccgt cgcgcctgtg
      361 acgcggcaga catgcccgcc gcgtcaccgc cgatgacgac caggcgttcc ttcgaacgat
      421 cagaagggcg atctgtacgg ctcatgttca tgggaacacg ctacgagggc cccgcatttc
      481 agtcctgtcg gctcaactct cctcactctc gctctcgtcc ggcgtcgccg ctgccgggcg
      541 cggccgacgc gtgcgggtga ggcggaacca cagcagcagg acgagggccg tggccacggc
      601 gaaggggaac accgcggcga gggccatggc cagccagcgg aacacggcga caaacgcgtt
      661 ccagccgccc gccagcgcgt ccacgaagcc ggggtcgtcg tccttgtccg acttcttcac
      721 cgccgtctcg gacagggaca gcgtgatggt ggcgaggctc gtgcggtcct tcagggactc
      781 ctgctgggcc agcagcgcct ccaggtccgc ctgacgcgtg ctcaactcgc cctccagggt
      841 gaccacatcg ctcagcttgg tcgcccggtc catcagctcg cggatacggg ccacgctggc
      901 ctgctgcgtc ttgatacggc tctccacgtc gacgacctgc tccgtgacgt cctcggcctt
      961 ggtcttgcgc tcgatcagct tgccggtgcc ctccagttcg ccgaggacct cctcgtactt
     1021 ctcggtgggc acgcgcagga cgacacgggt gcgttcgcga tccttgccgt cgcgggtcgt
     1081 cgactcgtcg gcgacgaagc cgccggcgtt ctcggcgacg gtgcgggcct cgtccagggc
     1141 cttcggtacg tccttgaccc gcacggtcag cgaggcggtg cggatgatgt ggctcggggc
     1201 gaccttgatc ggcgcgtcgg cggcctcacc gctgctctgg gcgctgccgc tgtcgccgtt
     1261 cagggcgccc tcctgccggc cggacatgtc cgccttgctg tcggaggccg ttgtgccacc
     1321 cgagctgtcg ccattggcgc cacagccggt gagcgccagg gcggcggcga ggaacagggc
     1381 ggccagggcc ccagcgggcc gccgggaacg tcgtgcgtgt gtttcggcca ttgcggcgta
     1441 cccccgaggg tcgtgacagg cttgttcgcc ttgctgacgg tccttcgacg cctgagccgg
     1501 ccggaacgtt ggcggcatcc ggtcccgaag cggtcacggt ccggactcgg cgaggccaca
     1561 tgcccccgca gggatgtcag cggcatctga gagggtggat ccatgagcgg atcacgtacg
     1621 ggcgccgggc atgccgtcgt catcggggcc gggatcgcgg ggctggccgc cgcgcacggg
     1681 ctgctggacc agggggtgcg agtgacggtg ctggaggcct cggaccgggt cggcggcaag
     1741 ctgctgcccg gcgagatcgc gggcgcgcgg gtcgacttcg gcgccgagtc gatgctggcc
     1801 cgccgccccg aggcggtcgc cctcgcgaga gcggtcggtc tcgccgaccg gctccagccg
     1861 cccgccaccg ccacggcctc cctgtggacc cggggtgccc tgcgccccat gccgaagggc
     1921 cacgtcatgg gcgtccccgg caccgcctcc gccctctccg gggtgctgtc cgacgagggg
     1981 ctcgcccgta tcgagcgcga cgccgacctg ccgcgcaccg aggtcggcga cgacgtggcg
     2041 gtgggggagt acgtggcggc ccgcctcggc cgcgaggtcg tcgaccgcct ggtggagccc
     2101 ctgctcggtg gggtctacgc gggcgacgcg taccgcatct cgatgcgctc ggcggtcccg
     2161 cagctcttcc aggcggcccg gacccgcacc tccctcaccg aggccgtccg cgagatccag
     2221 gcccgcgcgg ccgccgaccg gcagaccggc cccgtcttca tgggcatcga gggcggagtg
     2281 ggccaactgc cgctcgccgt cgccgagtcg gtgtcgtcgc gcggcgccga gatcctcacc
     2341 cggaccccgg tcacggagct gcgccgcgag gccgacggcg gctggcgcct cagcaccggg
     2401 gaccgcgtcc tgcacgccga cgccgtcgtc gtggccgtcc ccgccccggc cgccgccgac
     2461 ctgctccgcg ccgaggcccc cgaggcagcg gccgagctgg ccgccgtgga gtacgcctcc
     2521 atggccctcg tcaccctcgc ctaccgccgc gccgacatca ccctccccga gggcagcgga
     2581 ttcctggtgc cgccggtcga cgggcggacc atcaaggcgt ccacgttcgc ctcccagaag
     2641 tgggcctgga tcgccgacca gaaccctgac ctgcttctcc tgcgcacgtc cgtcggccgc
     2701 tacggcgaga cggagatcct tcagcgcgac gacgcccacc tcgtggacgt gtcgagaaac
     2761 gacctgcgcg cggccacggg cctggacgcc accccgctcg aaacccgcgt cacccgctgg
     2821 gacaacggcc tgccccagta ccccgtcggc caccacgcgc gcgtggcccg cgtccgcgag
     2881 cacatcggca agctgcccgg cctcgcggtc tgcggagcgg cgtacgacgg tgtcggcatc
     2941 ccggcctgca tcgcgagcgc ggccgccgcg gtcgaccaga tccacggtga cctgcgcgct
     3001 gtgcaggacc tcacggccaa cccggtgcag agcctgcacg gcggagcggg agaataagaa
     3061 catgagcgac gacgccccca ccaccgagtc cggccggatc ccgaacaagg gcaagctggc
     3121 caaggacctc aacgaggtca tccgctacac gctgtggtcc gtgttcaagc tgaaggacgt
     3181 gctcccggag gaccgcgccg gttacgccga cgaggtccag gagctgttcg accagctcgc
     3241 cgcgaaggac gtgaccatcc gcggtacgta cgacgtgtcc ggcctgcgcg ccgacgccga
     3301 cctcatgatc tggtggcacg ccgagaccag cgaccagctc caggaggcgt acaacctctt
     3361 ccgccgcacc aggctgggcc gcgccctcac gccggtctgg tcgaacatgg cgctgcaccg
     3421 ccccgccgag ttcaaccgct cgcacatccc cgcgttcctg gcggacgaga ccccgcgcaa
     3481 ctacgtgagc gtctacccct tcgtgcgctc ctacgactgg tacctgctgc ccgacgagga
     3541 ccgccgccgc atgctcgccg accacggcaa gatggcccgc ggcttcccgg acgtccgcgc
     3601 caacacggtc gcctcgttct ccctcggtga ctacgagtgg ctcctcgcct tcgaggccga
     3661 cgagctctac cgcatcgtcg acctcatgcg ccacctgcgc gcttcggagg cccgcatgca
     3721 cgtccgcgag gaggttccgt tctacacggg gcgcaggaag tcggtggcgg agctggtggc
     3781 agggctcgct taggcggatc acccgcgccc ctggtctttc aggggcgcgg ggcggtgttg
     3841 atcaggggct tcgccgcggg gcgcgaaccg acccgacgat tccgtaaagg accgtggaga
     3901 ggtgtcgcgc tacccgcggg gcccctgtgc ggccggcggc agcgaataat ccgccgacga
     3961 cggcgtgggc gacggtgccg tcggggacgg cgtcaccgga atcggcgagg cgggatcgtt
     4021 caacggcgcc ggcggcgccg gagagttggt gatcggcggc gcgctcgcgg acgcggcctc
     4081 ccgggcgatc gcgtcgtagt cgaccaaccc cgtggcctcc aggacccgga tgtggtcgag
     4141 cacggtcgtg ttggcggcgt cggcgagatc acggacgagc gagttacgag tcgtcgcccg
     4201 gacctgggcg acgacggaga acaccttgcc gtgcgccaga cgcagaatgt tggcgaactc
     4261 ccggtcgtac gtctcgccct gcgccgcgct caacgtctcc agccaggcct tctgctggtc
     4321 gctcggctga ttgggcagcg gcaggccgat ccgggcggcg acatcgcgga cccgggcgtc
     4381 gaggtgggtg tgcccttcga cgagatggtt cccggcggtc cgtacggcct cggtggtgcc
     4441 cttcgtctgg gcctgctgcc cggccggcag ctcccagagt cccgccagtc tgaccttggt
     4501 gatgaagtcc cggtccagcg cggacaacgg accgtactgc gtcgacaccg tggacgcgtt
     4561 cagtgtggcc acgccggtgc cggagcggtc cgcgtacgac cagatcggga aaaccatcgc
     4621 cacaagggtc gcggtcagcc cggcgacgat gagtccggtc ccgctgacga gtcttccgct
     4681 gtggtgggtg gatcgcatgg tgcctcctgc tcgcggcacc gcacgctagt gcgtttcggg
     4741 tgctgattgg cttgagaact ggcatgttac tgcccggtct acgccaactg ccgtacgggg
     4801 aggaagggtt gaggacggga caaagcgcgc cggatggggt aagcggaccg gcggacagaa
     4861 gctatgaaat gcctttcaag caggcgtgaa acccgtgcgg ggggcacggg tttgttaatc
     4921 gcagcacatc tcggggcgac ggggcttctg gtggacatcc gtgccgccgc ggagatccac
     4981 cagaagcccc ctaccccggc tcaacggcgc aggagcaccc tgcgggtcgc acgcgccagg
     5041 cgggcggccg ggcgccgtga gagcggggcc gggcccgacc gctccagcca ccacgtacgc
     5101 aacgcgcgct tcgcggtcgc gtcctccagc ccctgttcca gcagcacgtg ctcggcgaag
     5161 gagagggcgt cgcgccggta accgtcggtc atcgggtggc cctgcgcgta cgcgaggaag
     5221 gccggccggt acaccttccc gaggatctcc gggagttccg gcgccacctt ccccaccaca
     5281 tccgcccgct tggccgcgag ggcccgcgcc tgcacgccca gccgcacccg gtcgaacccc
     5341 tcgggcacgg gcgtcccgcc gaccagcgcg gacagcagcg cggcctgcgc cagcccgagc
     5401 cgctgccggg cggcgggctc ggcctccccg gcttcctcag cggcctcggc ctcggcctcc
     5461 gctgacggcg ccgccttctc ctcgggaccc cgtacctcgg ccttctccag gacccctcgg
     5521 atcgccccca actcccgctc cagctcgccc ggctcgggaa agttctcgtc gcgctccagg
     5581 aggacccccg gaggggtcac gcgggaggcc aggtcggcga ggatgtcgag gacctgctgg
     5641 gggaccgggt gggcgtggct gtcgtgccag acgccgtcgc gctcgaagcc gcccgcgaca
     5701 tggacgtacg cgatggcctc gactggcagc tcgtcgagcg ccttggcggg gtcctcgccc
     5761 cggttgacgt ggttggtgtg gaggttcgcc acgtcgatga ggagccggac tccggtgcgg
     5821 tcgacgaggt cgtacaggaa ctggccctcc gtcatctcct cgccgggcca gttgatgagg
     5881 gccgcgatgt tctccagcgc gagcggcacg ggaagcgcct cctgcgcgat gcggacgttc
     5941 tcgcagagca cgtccagcgc gtcccgggta cgcggcaccg gcagcaggtg tccggcctcc
     6001 agccgcggcg acgcggtgag ggcacccccc gcccgtacga acgcgatgtg ctccgtgacg
     6061 agaggcgcgc ccaggacctc cgcgcgctcg gcgaggtcgc gcagccgctg ctcgtcgggg
     6121 cggtcggcgc cgccgaggcc gagcgagacg ccgtgcggga cgaccgtgac accccgctcg
     6181 cgcaggcgga gcagcgactc ggggatgtgg ccggggcaga cgttctcggc gacgacctcg
     6241 acccagtcga cccggcccga cggtccggcc atgccctcga cggcgtcggc gatctccggc
     6301 cgccagccga tccccgcccc caactgcctg atctgctcca tcgtcccctc ctcggtcacg
     6361 gcttcaccag gacccgcgtg tcgtctcctt acggcggacc cgtgttccgg cgtgacggag
     6421 tcatggcccc ggcagccggg gccgaacccc ggggagggga ccttcagagc aacatttgag
     6481 cttccggagg ccactgcttc cggtggcccc gctttcggtg gctacgggac gaccggttcg
     6541 ccctgttcct tgttgagctc ctccgggtcc ggacggccgg tcgggaccag gccgggcgtg
     6601 gtcggcgacg ggaccgagct cacgcggggg ttggtggacg gctcggcggc gggcgcggcg
     6661 ggcggcacct gaccggggac gggcggcggc ggtccggtgg ggctcgccgt accgctgacc
     6721 gagttgttgg cgatggtctc gaagtcgacc tcgccggtgc cctccaggac cgtgatgtgg
     6781 tcgagcacgg tctggttggc gtcggaggcc aactggcgga tcagggtgtt gcgggtggag
     6841 ttccgcacgg tggcgatcgc cgggaagatc ttgccgtggg cggcacgcag caggttcgcc
     6901 caggtcttgt tgtactcggc ctcggtcttg gcggcggtca tctggtccag ccagccctgc
     6961 tgctgcgccg tcggctggtt cggcagctcg acgcccagct tcgccgcgat gacccgtgac
     7021 cgcttgtcga ggtcggcgtg gcccacgatc aggtggtcgg cggcttctct gacggacttg
     7081 ctgccactgc gctccagcgc ctgctgcccg gccggcagct cccacagacc tgccagccgc
     7141 acgcggatga gcaggtcgcg gtcggccggg gtcagcggcc cccactgcgt ggtcaccgtg
     7201 tccccggtgg gcacggccgc ggccgccgcg gcgttgcggt tggggtacga gtagaacacg
     7261 gggtaggcga ccgcactgat cgtgccgacg accgccacgg cgacgaggac agagcccttg
     7321 gagcgtcgca aaagagcctc ccggaggaaa ccaactgatc gttggggact gaacgttgct
     7381 tggggggtgg ggtgctgcct cggcttggcc gggccctgtc actggctgcg acaggcccgg
     7441 tccgtgccgt ggggccgcgt cagatcgtgc cgttggcgat ggcgtcgaag tcgacctcgc
     7501 cggtcttctc cagcatcgtg atgtggtcga gcacggtctg gttggtgtcc gaggcgagct
     7561 ggcgcaccag ggtgttctgg gtgccgttcc gcacctgccc gatcgccggg aagatcttgc
     7621 cgtgggccga gcgcagcaga ttcgcccaca cccggtcgta ctggtcgtcc gtggcgttgt
     7681 tcatctgctg gagccaggcc tgctgctgcg cgttcggcac gttgggcagc tcgacgccca
     7741 gctgggaggc cacgttccgc acccgctcgt cgaggtcctt gtgacccacg atcaggtggt
     7801 cggcggcctc cctgacggcc gggctgtccg accgctgcat cgcctgctcg gcggccggca
     7861 gctcccacag tcccgccagc cgtacccgga cgatcaggtc ccggtcggaa gccgtcagcg
     7921 gaccccactg ggtgttcacc atgccggacg ccatgttggc ctgggcggtg cccgaccggt
     7981 cggcgtagga ccatacgggg aacgccagcg cgccgacggt gacaacgagg gccaggctgg
     8041 cgatgaccga gccgttgaga cgctgcaaag tgatcctccc gggtgaagcc aactggtcgt
     8101 tggggcagtt acatggccag tgcaggaagg tacgtacggg gagcccgggg tgttcaacga
     8161 cctttgcacg ggccgagaac gcccagttcg gtgggcggac gcctcacgag aactcgggcc
     8221 ggacagcccc cgtggcgtcg tcgcgttgtt cgggagttgt ttgttcggca ccggtgcccc
     8281 gaacgcgaac aacgcccggg cccctacacc tggaggtgac cggtaccgtc gatcaaagga
     8341 gaacccatga agaaggcaat cccgctcaag cggatgacgg ccgcggccac cgcaggttcc
     8401 gcgctcctca ccgccggtct cctcgccgca gggcccgcgc aggcggcgac gccggaaacg
     8461 aactcccccg taagcgccct ggcctgcgtg gtcgatctgg acccgccgac caggggcggg
     8521 gccggggtga ccgccttgat ccgcaccagc ggctgcagtc agggcgtcaa gtggaccgcc
     8581 aagctccaga gctcccgctg gtggggctgg gccgatgacg ccgagcagac ctggaacggc
     8641 agccagtcgc gtcggctcac cgcgggatgc gccggggtcc acgaccacag ggtcatcgtg
     8701 caggccgtcg tcgacggcca gggcagcccg tggaaggtag gacccaaggc cacgctcaac
     8761 tgcggctgat cccgatcacc cggaccgccc gtgcggggcg gtccggcgac cgggccgcac
     8821 ggggaatcca cacagctgtt cagccgcgca gcgccggatg gtccgcgacg accgtgcacg
     8881 agcccggggc gatctccgtg aagcccgcgt cgcgcacgag cggcaggccg gaggcggtga
     8941 ggccgggcca gtcggccggg gtggcggtgc ggacggcgag ggggaagccg gcatcgtgcc
     9001 aggcggtgcg ggcctcctcg gagagggccc accaggcgag ttgggcgccg tggccggcct
     9061 gggccatggc cttgccggcg gacatgtcga ggtccgggct catccagatg accggggcgg
     9121 agaggtcggg ctcggccggg gattccgggt cgtcgaggtc cgtgccggac acctggagac
     9181 gggccaggtc cttgggccag ccgtcgaggg ggaccggcgg aaagacgcgc acctccgccg
     9241 acttgcccgt caccgtgatc ccgggcagcg cctcggcccg ccgccactcc gcgccacgcg
     9301 cccgccggac caccttgcgg atccgggcgt cctgccagtc ccgcatcgcc tcggcccact
     9361 ctcccgcgcc caccgaccgc tcgtcgctga gcatcaccag caccgcccgc gccgccgtct
     9421 ccaacgcgtc cgtacgcgcc gggggcgacg ccttctcgat gtgcacgacc agcggcagca
     9481 cgaactgcgg tgcctcgtcg cgggaggtcc gctcgtgccg gaaggggctg tcctgggagt
     9541 tcgggtcacc ggtgctcacc cgcccagtct gccagccgga agatccgttc ccggatgggc
     9601 cgcccgtaca gccgtacgac ggttgtacga ggatgggggc atgggacgtg agttactgct
     9661 gagtctggaa ggtgtcggcc gccgctacgg gttccggggg ccgtggatcc tgcgcggcgt
     9721 cgacctcgcc gtcgcccccg gcgcgctgat ccgcgtggag ggcgccaacg gcaccggcaa
     9781 gtcgacgctg ctgcgtgtcc tcgccgggat cgacgccccc acggagggcc ggatggcggg
     9841 gcgcccgcga acggcgtacg ttcccgagcg cttccccgcc gcgctgccgt tcaccgccgc
     9901 cgagtacctc actcacctcg gcgctgtcca cggccttgac cgccctgccg ccgcccgtgc
     9961 cgccgacgac tggctggaac gcttcggagc cgccgagtac gcccgtacgc cgatggccca
    10021 gctctccaag ggcagcagcc agaaggtcgc cgtcgcccaa gcgctcctcg cggaaccgga
    10081 gttgctcgtc ctcgacgagg cgtggaccgg cctcgacgcc gacgcccgcg aggagttgga
    10141 gcgggtggtc gtcgagcgga ccgcggccgg ggccgccgtg gtgttcgtcg accacgatcc
    10201 gcgtcggctg gcgggggtgc cggacgcgac ctacgcggtt gccgggggcg ccctcaacct
    10261 ccgtacgggg gcggggactt cggaaggggt gggcgagggc cctgcggtgg tcgtcgaggc
    10321 gcgcggaccc tctcgtgcgc aagtaccgga tgaggtggtg aagttggcgg ccgatgtgga
    10381 ggagacaggc gccggcagcc accggttctc cgttccggag gcggggtcgg atgccttgct
    10441 gagggcgttg ctgagggctc ggccgccgtg gcatgtggtg agtgtggggc ccgggaaagc
    10501 gatggcagaa ccggaagagg aaagcgaacc ggaagtgacc ggcgaactgg aagtggaacg
    10561 ctcctgatga ccgccctcct ccgctaccag gccgccctcc tgctccgctc ccagcgctgg
    10621 ttgccgcccg tcatcctgta cgcggccttc ctcgccatcg gggtgcagag cgggcagccg
    10681 gtgctcgact cgctcggcta cacggcggcc gcgctgctgc ccgtggccgc ctggctggta
    10741 cgtatctgcg ccaccaacga gccgcccgcg gcccggagtt gtacgggagc ggcggccgga
    10801 ccgggccggg cgcacctggc gtgtctgctg gtcgcgctct cggcggccgt gcttctcggc
    10861 gcggcggcca cagccttcgt cacgatcatc agcgctccca cgagcacgga ccaccagacg
    10921 cgtatcgagg cggtcccggc ggccggcgcc gggcttctcg cggccctcgt ctgcgccctc
    10981 ctcggcgcgg ccgtcggtac gctcacgaac tggccgcttc tgcgctcgcc gggccaggcc
    11041 gtccccgcgc tcctcctcgg cgcgctgctg gccctggtgc tcgcgggctc cccggcccgc
    11101 gcggcggtca cgtccctggt cgaaggctcg cagcacgcga ccgtcccggt ccccgtcctg
    11161 cccctggtcg ccgccgcgct gctcacggcg gtggcgatcg ccgtggcctg cgccctgacg
    11221 acccgccgct caccctgaac aggcgttgcg ctcggcctcc cgccactcgc acaccgggca
    11281 cagggtgatc cccttgtacg actccgggta ctcggtgggc tcctggcaca gcacacaggc
    11341 g
//
