LOCUS       NZ_CP022161            20891 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6410446
            Orig. end                         :: 6431337
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20891
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="27"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20891
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20891
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10891](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10891
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(286..1227)
                     /locus_tag="CES90_RS28535"
     CDS             complement(286..1227)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327005.1"
                     /locus_tag="CES90_RS28535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_189785906.1"
                     /transl_table=11
                     /translation="MSDRDRDHARVERSAGLAHRVPDLGALELLLAVARLGSLGRAAQS
                     LGITQPAASSRIRSMERQLGVALVDRSPRGSSLTDAGALVTDWARRIVEAAEAFDVGAQ
                     ALRDRRDSRLRVAASMTIAEYLLPGWLIALRAERPDTAVSLLAGNSTVVAERLLADEAD
                     LGFVEGPTVPAGLDAAVIAHDHLIVVTAPDHPWARRRKPLDAAELASTPLILREKGSGT
                     RQVLEGALGGLARPLIELSSTTAVKSSALSSAGPAVLSELALGEELSARRLVRIPVEGI
                     RLRRALRAVWPTGHRPAGPARDLLSLTRGATG"
     gene            complement(1359..1961)
                     /locus_tag="CES90_RS28540"
     CDS             complement(1359..1961)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128360.1"
                     /locus_tag="CES90_RS28540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189785905.1"
                     /transl_table=11
                     /translation="MGDHKEQPLRVGAAVRRRRRALELTLSVVAERSGLSVPFLSQVEN
                     ERARPSKPSLERIADALGTTAVELLAAADPACSVDVVRAAGAADDAFTPADSHSRSLVR
                     GHHQLHAMEFTGDHDEGREVQHRNDELMYVADGAVEVEAEGRAHRLGRGDTLYMSGGVR
                     HRWRATVPDTRVIVVAVADHIEALEDRHGGRGRAGGA"
     gene            complement(2157..3149)
                     /locus_tag="CES90_RS28545"
     CDS             complement(2157..3149)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639428.1"
                     /locus_tag="CES90_RS28545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_229914159.1"
                     /transl_table=11
                     /translation="MPTRRLAPAALALALALTVPLLAAAGDALPLTKVAPASPATARFA
                     ELAGDVRQADGHAYDVRDHTGRTMDTAEITQTPDGTYLAVYHSTLPDGRFHAAVATSTD
                     LRTWTRRHDFGPGTSQASLVPNGRGGYVLAYEKDPDNHIAVRGYPDLDALLTGEADRAF
                     DAPRTLSRCAEGTPDVTAVDGDTIELTGHYQESCGTDRQLRARLRDFTTWRAEPDDRLD
                     RAVAAWGTAGNIGDRTRVALGGEPIVLIEGQHRRDDFGSWRTYAYDPVTGRADRLTPRT
                     HGGSEALANPSATVLTTPEGRPALLVSLFVPREGAAHGEAGQLVYWREL"
     gene            complement(<3346..3952)
                     /locus_tag="CES90_RS28550"
                     /pseudo=""
     CDS             complement(<3346..3952)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977205.1"
                     /locus_tag="CES90_RS28550"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYKVFGRRPDQAVDRLRAGTARAVLRADGTTAAVIDRRRDRRLLH
                     GGGRPDLRRHGPVRLRQVHPAAHAQRAPGATVGHVRFGGRDLTALSDRELRAVRAHGIS
                     MVFQHFALFPHRSVLENAAYGLEVQGVPRAEREKRATEALALCGLAGWEKSWPDELSGG
                     MQQRVGLARALATDADPYRPDRYRRGHPPPPGRRLRGLL"
     gene            4284..5228
                     /locus_tag="CES90_RS28555"
     CDS             4284..5228
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485279.1"
                     /locus_tag="CES90_RS28555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5'-3' exonuclease"
                     /protein_id="WP_189785976.1"
                     /transl_table=11
                     /translation="MGYGMMRGVTRRLMLLDTASLYFRAYFGMPESVKAPDGTPVNAVR
                     GLLEFIDRLVRDHRPTDLVACMDADWRPHWRVELIPSYKAHRVAEEHAVGPDEEEVPDT
                     LSPQVPVIEAVLDALGIARVGVAGYEADDVIGTFTALAKEPVDIVTGDRDLYQLVEDAR
                     EVRVLYPLKGVGTLQLTDEAALREKYGVDGRGYVDLALLRGDPSDGLPGVPGIGEKTAA
                     KLLDRFGDLAGIMAAVDDPAASLTPSQRKRLDEARSYVAVAPRVVRVAVDVPLPDVDTA
                     LPRTPRDPATLEALATRWGLGGSLQRLLTTLQG"
     misc_feature    5258..5271
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    complement(5374..5392)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.69"
                     /tool="antismash"
     misc_feature    complement(5376..5396)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            5410..6267
                     /locus_tag="CES90_RS28560"
     CDS             5410..6267
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988113.1"
                     /locus_tag="CES90_RS28560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="siderophore-interacting protein"
                     /protein_id="WP_189785904.1"
                     /transl_table=11
                     /translation="MAERPVRRTPKPHSARVVRTERLTPHMQRVVLGGDGLAEFSTRGS
                     TDHYVKLLFGPEGVTYPEPFDMERIRAEFSRDQWPVTRTYTVRAWDPELRELTIDFVLH
                     GDEGLAGPWATRVQPGELVRFLGPGGAYAPNPEADWHLLVGDESALPAIGASLEALPDG
                     ARVHALVEVAGPEEEQKINSDVDVVWLHRGDRPVGSVLVEAVRALEFPEGRLHAFVHGE
                     AGFVKELRRLLRVELQIPREDLSISGYWRLGHDEDGWQASKKEWNARVEAEQEGEQEGV
                     STPA"
     misc_feature    6542..6556
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            6737..6910
                     /locus_tag="CES90_RS49970"
     CDS             6737..6910
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS49970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_229914158.1"
                     /transl_table=11
                     /translation="MTFRLTHYDGDTFSFETVGENASGPSGVTFRGDQGGTATQVTIGA
                     FDKGGLGTFRRG"
     gene            complement(6923..7735)
                     /locus_tag="CES90_RS28570"
     CDS             complement(6923..7735)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010058184.1"
                     /locus_tag="CES90_RS28570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-formylglutamate amidohydrolase"
                     /protein_id="WP_189785903.1"
                     /transl_table=11
                     /translation="MNDPTAPHRLTPGAPDSPVILHAPHGARKIPAAVRAEILLNDRSL
                     TRELDHITDTHTDRIAEQAAARSATRPWTFVNRLSRLVVDPERFPDEREEMLAAGMGAV
                     YTRTTHGEDLRPADHDGRPLLERYFHPYAAAMTDAVTDRLEAAGRAVIIDVHSYPSAPL
                     PYELHGDGPRPPICLGRDPFHTPPDLLARAEETFAGFGGTGVNSPFAGAYIPLKYYGND
                     PRVSALMIEIRRDTYMTEPGGPAGPGLDALAEALAELVDAVTAAPPTR"
     misc_feature    complement(7864..7878)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            7966..9489
                     /locus_tag="CES90_RS28575"
     CDS             7966..9489
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382898.1"
                     /locus_tag="CES90_RS28575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid permease"
                     /protein_id="WP_189785902.1"
                     /transl_table=11
                     /translation="MTSTASADVRPDPPHSPDDRSLTAFGYRQELHRSLGRYASFAAGF
                     SFISVLTTVFQFFAFGYSFGGPVFFWTWPAVLLGQLAVAACFAELAARYPLSGAIYQWS
                     SRLSNLTFGWFAGWIMVIGQIVVVAAAALALQMVMPAIWSGFQLVGGDPTPTSATGAAN
                     AAVLGVILLLLTTVVNVLDNRVLSLVNRVGVTAEIIGAALIIVLLLTHAERSPGITFHT
                     AEGSTGLLGALLVGSFMAAYVMIGFDSAGEMSEETRHPRRTAPRTILTALGAAGLLGGL
                     IVLGGLLAAPSLTDGKLGVDGLSYVLTSSLGDGVGRLLLADVVVAITVATLAIQTSACR
                     MLFSMARDGQLPFATRLARVNPRTGMPSACALVVGLLAAALLLLNFTSPDAFLAIGTTC
                     IVMLYLAYAMVTGPLLVRRLKGAFTTDDTDETGKPLFTLGRWGIPINAFALLYGLFMTL
                     NLAWPRAEVYDPSGGHWWFQWFTVLFLVVTVGLGVLYRLTRARRVHSAE"
     misc_feature    complement(9616..9629)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    9629..9643
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     misc_feature    complement(9707..9725)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.73"
                     /tool="antismash"
     misc_feature    complement(9710..9725)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            10001..10891
                     /locus_tag="CES90_RS28580"
     CDS             10001..10891
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382903.1"
                     /locus_tag="CES90_RS28580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_232791333.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-50, bitscore: 172.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAARNMTALFAADDHYCDEKIEGVSLAMSASRLAGSLTALENGS
                     RLPDCPSIEGFVGSDPVTRALRATAEHITRLGTPAQVGRLRHETIATFLAMAAENAWRI
                     AGHVPDPAEYLAHRKYNGAMACLVLIDAVGGYELPVRDWEEPGVRSLSLAASLMIMLVN
                     DLYSVAKESADIGSHSLPTVLSARHGWSLERSMCATGELHDRLMREYLRLEPDVARHAS
                     PELARYLAGLRHWMRGNLEWHTLTGRHNRRAGRPTPRTGPHGPTHHRMRADVHYSAAGV
                     CPHCGDRHNAATAVA"
     gene            10956..11897
                     /locus_tag="CES90_RS28585"
     CDS             10956..11897
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279: pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661671.1"
                     /locus_tag="CES90_RS28585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RluA family pseudouridine synthase"
                     /protein_id="WP_189785901.1"
                     /transl_table=11
                     /translation="MRRRTPPPPSPLPQRDGVDPVRVRLPAGDAWATVRDHLVARLAAG
                     PGVIDGMLDAGRIVDVTGRPVPRDMAYVPGMFVWFHRELPHEEQVPFEVGVLYRDEHVV
                     VADKPHFMATTPRGSHVAETALARLRRQLGIPTLGAAHRLDRLTAGVVLFTVRPEERGA
                     YQSLFRDKRVAKEYEAVAPYDPVLVLPRTVRSRIVKERGVVAAREVEGEPNAVSRVELL
                     EHRNGRARYRLLPRTGQTHQLRVHMSALGVPILGDPLYPTVTGPVPTGDFRRPLQLLAR
                     ALEFTDPVTGRDHRFVSPRVLRAWSSYEEWAG"
     gene            complement(11935..13416)
                     /locus_tag="CES90_RS28590"
     CDS             complement(11935..13416)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117696.1"
                     /locus_tag="CES90_RS28590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_189785900.1"
                     /transl_table=11
                     /translation="MTPETHSPTSTDDPKLGPPPGCPAHGNGPGSLRRLYGPEAEDLGA
                     VYEKLRAEHGAVAPALLHDDVPIWVVLGHGENLHMVSTPSQYCKDSRLWTPMQDGTVKP
                     DHPLMPHFAWQPICCHAEGEEHLRLRGAVTGAMSTIDYRSIRRSINRATQHLVNQFCED
                     GRADLVSQFAEHLPMAVMCEILGMPEEYGDRIVQAARDMLKGTETAIASNQYVMDVLMR
                     LTARRRAEPQDDFTSHLINHPAGLNDEEIGQHLRVVLIAAYEATANLLANVLRVVLTDP
                     GFRAQLNGGQMTVPEAVEQSLWDEPPFSTVFAYFAKQDTELGGQRIRQGDGLLLGIAPG
                     NVDPRVRPDLKANMQGNRAHLAFSGGPHECPGQDIGRSIADVGVEALLARVPDIQLACG
                     EHELRWRSSIGNRHLVELPVKFEPKTPEEVMERPTVKPVAPLRPNNWQVSTEQSQPTAS
                     EPAVPADEPTPTSASPEPARRPGLYRRLLRWWRRN"
     gene            complement(13562..14182)
                     /locus_tag="CES90_RS28595"
     CDS             complement(13562..14182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325210.1"
                     /locus_tag="CES90_RS28595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_189785899.1"
                     /transl_table=11
                     /translation="MDFKSSDTITGPRTEDHLPHTAQAAAKIVIVGGFGVGKTTMVGSV
                     SEIKPLTTEETMTQAGIGVDDNYGSKSKTATTVAMDFGRISITDQLVLYLFGTPGQERF
                     WFLWNGLFEGALGAVVLVDTRRLEVSFDVMGRLEERGVPFVVAVNDFPDAPRYALDELR
                     QALDLAEEIPIVRCDARRRASSRDVLMTLMSFLHSLAMSAAST"
     gene            complement(14163..14576)
                     /locus_tag="CES90_RS28600"
     CDS             complement(14163..14576)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485263.1"
                     /locus_tag="CES90_RS28600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_189785898.1"
                     /transl_table=11
                     /translation="MTPPQRRRRHPKQEPPPPPLELEGPKDGEGERPPERLYILTGEDG
                     ERAPIDLVTLIVARADPPRSAAPEQSALLRLCQAPLSVAEISAYLNLPISVVTVLLTEL
                     LTAELVQARAPVIRQARADRSLLEAVMHGLQKL"
     gene            complement(14573..14980)
                     /locus_tag="CES90_RS28605"
     CDS             complement(14573..14980)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549147.1"
                     /locus_tag="CES90_RS28605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_189785897.1"
                     /transl_table=11
                     /translation="MIQQRANFDWMLKDLADGVPGIQQIVVLSADGLRIARYGGDPDAA
                     DRVAAACAGLQSLAGAVASEIPQSDGEMRMVIIQINGGYFYLMAAGSNAYLAVLANEIA
                     EPGLMSNRMRDLVDRIGSHLTSPPRRNGQTV"
     gene            complement(14977..16644)
                     /locus_tag="CES90_RS28610"
     CDS             complement(14977..16644)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327013.1"
                     /locus_tag="CES90_RS28610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_189785896.1"
                     /transl_table=11
                     /translation="MVSVQSPPGGRELPDVRVLLLPAILMAAATGTTVSLVTGSVRLAV
                     GLCGTVATLLLVAVAVIAVRGRRRTVRQLRAEQGRRTASLEQRIAAHDQEFTRLGKEIL
                     PAALYRLRGGESPSEVIRHVIDGDAEWRELPKSQRDVLYTVLDVIDRETAMRDSSQRSF
                     VNIARRVQAIVHQQNKELREMEEDHGRNPEVFDDLLRIDHGTALIGRLADSIAVLGGSR
                     PGRVWPKPVPLYSCLRGAMSRILEYRRIELHSIAKVNVNGVSVEPVIHACAELLDNATR
                     YSPPHTKVHVTAIEVQTGIAIEIEDGGVSLNEESRAKVEDMLKKAQRGEDIQDMGGSPR
                     LGLAVVGRLSTMYKMKISLRPSAYGGVRAVVVVPRNMLTEEPAPGLAHGIGAAAVPTMD
                     TGGVEGPDRKPKRRRPTTGPRIPSSAEEMAPGMEDDVPVVTEWTANGLPQRRSRMTIPL
                     SQRYAEAAAAEAAAEAAMAAAPVWQPEPEPKKELPPPGLWVEAFMEGLKRDPDPKAATR
                     NPNDAAAPAESSAATGFTASTANNESAHSEAGDEGDLK"
     misc_feature    16734..16743
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    complement(16734..16748)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.91"
                     /tool="antismash"
     misc_feature    16735..16748
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    complement(16736..16749)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.84"
                     /tool="antismash"
     gene            complement(16982..17617)
                     /locus_tag="CES90_RS28615"
     CDS             complement(16982..17617)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114420.1"
                     /locus_tag="CES90_RS28615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189785895.1"
                     /transl_table=11
                     /translation="MGSAGGTGGRKVGRPRAEHRPDTGLSPRDELLAAAAELFTTHGYA
                     ATSTRALADRAGMRQASMYHYVSGKEELLAELLESTVTPSLTLARRLLADDATPAEDRL
                     WELCRTDVQLLCGGPHNLGGLYLLPEVRTERFAGFHAVRAELKDAYRQLIAATAAGAAL
                     AKSELDLRTDLVFGLIEGVILVHRSDPDRPVSAFADATADAALRIAGV"
     gene            17857..18681
                     /locus_tag="CES90_RS28620"
     CDS             17857..18681
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327016.1"
                     /locus_tag="CES90_RS28620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="urea amidolyase associated protein UAAP1"
                     /protein_id="WP_189785894.1"
                     /transl_table=11
                     /translation="MATATTYGARDHARAQEGTRTEAMPVVPASSWPEPPCEASRLVWA
                     ETVAGGNYTHRVLARGTEFRLTDTHGDACAHLLLHHADRPWERLNVADTVKVQWNAYLG
                     EGVLLLSDQGRVLASVVADTSGRHDALCGTSTLVRNTERYGDGTPQSPSPAGRELFKLA
                     AAKNGLDPRDLPPSLSFFQGVRVRDDGTLDFTGSVGPGGSVTLRAEQDVTVLIANVPHP
                     VDPRPEYVSTALEVLAWRARPTRPGDALWDATPEGRRAFLNTAEFLAARGIA"
     gene            18678..19283
                     /locus_tag="CES90_RS28625"
     CDS             18678..19283
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019066130.1"
                     /locus_tag="CES90_RS28625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="urea amidolyase associated protein UAAP2"
                     /protein_id="WP_189785893.1"
                     /transl_table=11
                     /translation="MKTVVVPARAAWSSVIRAGAALTITDLHGNQAVDFLVYDAHDTSV
                     RYSAPDTIHAQGGIFLTTGSVLMSNEHTPLMTVVADDVGRHDTVGGACSKESNTLRYGH
                     HTWSQHACVDNFLAEGAKHGLGKRDLVSNINWYMNVPVEKDGTLGIVDGISAPGLSLTL
                     RAERDVLVLVSNCPQINNPCNGFDPTAVEMTITEAGGA"
     misc_feature    19884..19899
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    complement(20351..20364)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 cgggggcggg ggtggggtgg gttttggggg ttcagtggca tccggagatg ggggaggacg
       61 ttcgggtgat gcgggcgttg gcgctggccg ctggttgagt cggtttttct cgccccgcgg
      121 cccctacccg tcccatccac gtcccatcca cgtcccatcc cccagggctg ccgccccttc
      181 gaccccgctg cgccttccag ctcgggggcc tccggttcgt tggcgagtgc gggttgttcg
      241 tggcttgtcg cgcagttccc cgcgcccctt gcaggggcgc ttcggtcagc cggtggcgcc
      301 tcgggtcagg ctcagtaggt ctcttgctgg gcctgcgggt ctgtggcccg ttggccagac
      361 cgctcgtagg gctcggcgta ggcggatgcc ctctacgggg atgcggacca ggcggcgggc
      421 ggagagttcc tcgcccaggg cgagctcgct caggacggcg gggccggcgc tgctgagggc
      481 ggaggacttg accgccgtgg tggaggagag ctcgatgagg gggcgggcga ggccgccgag
      541 ggccccttcc aggacctggc gggtgccgga gcccttttcg cggaggatca ggggggtcga
      601 ggcaagctcc gccgcgtcca gcggcttgcg gcggcgggcc caggggtggt cgggggccgt
      661 cacgacgatc aggtggtcgt gggctatgac cgcagcgtcc aggccggccg gtacggtcgg
      721 tccctccacg aagcccaggt ctgcctcgtc tgccagcagc cgctccgcga ccaccgtcga
      781 gttgcccgcg agcagcgaga ccgccgtgtc cgggcgctcg gcgcgcagcg cgatgagcca
      841 gcccgggagc agatactcgg cgatcgtcat gctcgcggcg acccgcagac gcgagtcgcg
      901 ccggtcccgc agcgcctgcg cgcccacgtc gaacgcctcg gccgcctcca cgatccgccg
      961 ggcccagtcc gtgaccagcg cccccgcgtc cgtgaggctg gacccacgcg gcgaccggtc
     1021 caccagggcc acgcccagct gccgctccat cgaacggatc cggctgctcg ccgccggctg
     1081 agtgatcccc aacgactggg ctgcccgccc gagcgagccg agccgtgcga cggccagcag
     1141 cagctcgagg gcgcccagat ccggcacacg atgggccagc ccggcgctcc gctccacacg
     1201 cgcatggtca cgatcacggt cgctcataac ttcagcttat gccggggtgt ggagtgcctg
     1261 agagctcggg tgagtgcggt tgcgatcgcg ggcgcgggga actgcgcgag cacccccacg
     1321 cacccgcagc cgccaacccg accgaaccac ccgagctctc aggcgccccc cgctcggccg
     1381 cgccccccgt gccggtcctc cagggcctcg atgtggtcgg cgacggccac cacgatcacc
     1441 cgggtgtcgg gcacggtggc ccgccaccgg tgccgtacgc cgccggacat gtacagcgtg
     1501 tcgccgcgcc cgagccggtg ggcgcgtccc tcggcctcga cctcgacggc accgtcggcg
     1561 acgtacatca gctcgtcgtt gcggtgctgg acctcgcggc cctcgtcgtg gtcgccggtg
     1621 aactccatgg cgtgcagctg gtggtgaccg cgcaccaggg agcgcgagtg ggagtcggcg
     1681 ggcgtgaacg catcgtcggc ggcgccggcg gcgcgtacga cgtcgacact gcacgccggg
     1741 tcggccgcgg cgagcagttc gacggcggtg gtgccgagtg cgtcagcgat gcgttccagg
     1801 gagggcttgc tggggcgggc cctctcgttc tcgacctggc tgaggaaggg gaccgacagg
     1861 ccgctgcgct cggccacgac ggagagggtg agctccagtg cccggcgccg ccgccggacg
     1921 gccgcgccca cccgaagggg ctgttctttg tggtcgccca tagctccggc tccctccttc
     1981 gctcgtcggt cggctctcgg acgcctacgg gtccggttac ggatgcccac cggcccgggg
     2041 ctcatacagg actcatccgg cgcacatctc ctgatgagtt ctctgcaccc tacgcatgtt
     2101 cggcaaaccg tttcatgcgc ccgtcacatc cctgtaaacc ggggaggggt tcatgctcac
     2161 agttcgcgcc agtagacgag ctgtcccgcc tcgccgtgcg ccgccccctc ccgcggtacg
     2221 aagaggctga ccaggagcgc gggacgcccc tcgggcgtgg tgaggacggt ggccgacggg
     2281 ttggccaggg cctcgctgcc gccatgggtg cgcggagtga gacggtcggc gcgcccggtc
     2341 accggatcgt aggcgtacgt ccgccaactg ccgaagtcgt cgcgccggtg ctggccctcg
     2401 atcagcacga tgggttcgcc acccagtgca acgcgggtgc ggtcgccgat gttcccggcc
     2461 gtcccccagg ccgcgacggc acggtccagc cggtcatcgg gctcggcgcg ccaggtggtg
     2521 aagtcccgta gccgggcgcg gagttggcgg tccgtgccgc aggactcctg gtagtggccg
     2581 gtgagttcga tcgtgtcgcc gtccacggcg gtgacgtcgg gcgtgccctc ggcacagcgc
     2641 gagagggtgc ggggtgcgtc gaaggcgcgg tcggcctcac ctgtcagaag ggcgtcgaga
     2701 tcggggtagc cgcggaccgc gatgtggttg tccggatctt tctcgtacgc cagtacgtaa
     2761 ccgccacgtc cgttcggtac gagtgaggcc tggctggtgc ccgggccgaa gtcgtggcgg
     2821 cgggtccagg tgcgcagatc ggtcgaggtg gcgacggccg cgtggaagcg gccgtcgggg
     2881 agggtcgagt ggtagaccgc gaggtaggtg ccgtccgggg tctgggtgat ctcggcggtg
     2941 tccatggtcc ggcccgtgtg gtcccgtacg tcgtacgcgt ggccgtcggc ctgtcgtacg
     3001 tcgccggcca gctcggcgaa cctggcggtc gcgggggacg ccggcgccac cttcgtgagc
     3061 ggcagcgcgt cgcctgcggc ggcgagcaac gggacggtga gggcgagcgc gagcgccagg
     3121 gcggcggggg cgaggcggcg tgtgggcatt gtgggcatgg gggctcacag gaacgggtgg
     3181 ggcgggcagt cgagagtacg ggcgcctgcc cggtcccgag cgcgcgaaga gaggtggggt
     3241 tcgccacatg gctcgcccca cccctctgta cggcccgtca ggggctgtgg accctccaga
     3301 cgccgtgggc gtccatctgt ccgccgcgtc cgggttccgg ctgatgaagg aggccacgta
     3361 gtcgtcggcc gggcggagga ggatgtcctc ggcggtaccg gtccggacga tacggatcgg
     3421 cgtccgtggc gagggcgcgg gccagaccga cgcgctgctg cataccgccg gacagctcgt
     3481 cgggccagga cttctcccag cccgccaggc cgcacagggc gagcgcctcg gtggcgcgtt
     3541 tctcgcgttc ggcgcgcgga acgccctgga cctccaggcc gtacgcggcg ttctccagga
     3601 cgctgcggtg cgggaagagc gcgaagtgct ggaagaccat gctgatgccg tgcgctcgga
     3661 ccgcccgcag ttcgcggtcg ctcagcgcgg tcaggtcccg gccgccgaag cggacgtggc
     3721 cgaccgtggc tccaggagcc cgttgagcat gcgcagcagg gtggacttgc cggagccgga
     3781 caggcccatg acgacgaaga tccggcctgc ctccaccgtg aaggaggcgt cgatcacggc
     3841 ggcggtcgat cacggcggcg gtggtgccgt cggcgcgcag tacggcgcgg gctgtgccgg
     3901 cgcgcaggcg gtccaccgct tggtcgggtc ttctgccgaa gaccttgtac aggttctcgg
     3961 cctggagcct ggagcctgga gggctgagtg gctgacacag atacctctcg gtccgcaaac
     4021 aggacagccc gcctcccccg cccgcaggac ggccgtggag cacggcggga tcggcccgcc
     4081 cgaccggtgg catcacactg ttgacaccag gtctccacag gtcggcacgc cagccttgcg
     4141 ttgctccggg gctgcacgtg cccacgcccg agcagggcaa acgggaaagt ggccggcttc
     4201 gcagatcgtt cactggtgca cacgtgcggc gcgtacgcct ggcgcgtgca cgggtccgcg
     4261 tccgcgtcgg ggacagcctg tcggtggggt acggcatgat gcggggcgtg acccgacgcc
     4321 tgatgctcct cgacaccgcc tcgctctact tccgcgccta cttcgggatg ccggagtccg
     4381 tgaaagcccc ggacggcacc ccggtgaacg ccgtgcgcgg gctgctggag ttcatcgacc
     4441 gcctggtccg ggaccatcgg ccgacggacc tggtggcgtg catggacgcg gactggcggc
     4501 cacactggcg ggtcgagctg atcccctcct acaaggcgca ccgcgtcgcc gaggagcacg
     4561 cggtcgggcc cgacgaggag gaggtgccgg acaccctgtc gccgcaggtg ccggtcatcg
     4621 aggcggtgct ggacgcgctc ggtatcgcgc gcgtgggcgt cgccgggtac gaggcggacg
     4681 acgtgatcgg cacgttcacg gccctcgcga aggagccggt cgacatcgtc accggcgacc
     4741 gcgacctgta tcagctggtc gaggacgcgc gcgaggtgcg cgtgctgtac ccgctcaagg
     4801 gcgtggggac gctgcagctc accgatgagg cggcgctgcg cgagaagtat ggggtggacg
     4861 gccgggggta cgtggatctg gctctgctgc gcggcgaccc gagcgacgga ctgccggggg
     4921 tgcccggcat cggcgagaag acggccgcga agctgctcga ccggttcggc gacctggccg
     4981 gcatcatggc cgcggtcgac gacccggcgg ccagtctcac cccgtcgcag cgcaagcggc
     5041 tcgacgaggc gcgctcttat gttgcggtcg cacccagggt cgtgcgggtg gccgtcgacg
     5101 taccgttgcc ggacgtcgac acggcactgc cgcggacacc gcgggacccg gccacactgg
     5161 aggcgctcgc cacgcgctgg ggtctggggg gatcgttgca gcggctgctc acgacacttc
     5221 aggggtgagg aggggacgga acgccggggg atgggacggc acttgggttg cgagggcccc
     5281 gagccactcg tgagagccct gaggcgcgac tcacatcgcg aagatgtggt ccccgcggcg
     5341 aacatggggc gttcatgaag ggaagatgat aacttaggta agccttagct aggtatttgg
     5401 gaggctgtca tggcagagcg tccggtacgc aggaccccga agccccactc cgcgcgagtc
     5461 gtccgcaccg agcggctcac cccgcacatg cagcgggtcg tcctcggcgg cgacggcctc
     5521 gccgagttca gcacacgcgg cagcaccgac cattacgtca agctcctgtt cggccccgag
     5581 ggcgtgacct accccgagcc cttcgacatg gagcgcatcc gcgcggagtt ctcccgggac
     5641 cagtggcccg tgacccggac gtacaccgta cgtgcctggg atcccgaact gcgcgagctg
     5701 accatcgact tcgtgctcca cggcgacgag ggcctcgccg gcccctgggc gacgcgggtc
     5761 cagccgggcg aactggtccg cttcctgggc cccggcggtg cgtacgcgcc caacccggag
     5821 gccgactggc atctcctcgt cggcgacgag agcgccctgc ccgcgatcgg cgcctcgctg
     5881 gaggccctgc ccgacggggc ccgggtccac gcgctcgtcg aggtcgccgg ccccgaggag
     5941 gagcagaaga tcaactccga cgtggacgtc gtctggctgc accgcgggga ccgccctgtc
     6001 ggctcggtcc tcgtcgaggc cgtacgcgcg ctggagttcc ccgagggccg actgcacgct
     6061 ttcgtgcacg gcgaggcggg cttcgtgaag gagctgcgcc ggctgctgcg cgtcgagctt
     6121 cagattccgc gcgaggacct gtcgatctcc ggctactggc gcctcggcca cgacgaggac
     6181 ggctggcagg cgtcgaagaa ggagtggaac gcgcgcgtgg aggccgagca ggaaggcgag
     6241 caggagggcg tgtccacacc agcgtgaccc ccgggccggg tccgcctcca gcctccgccc
     6301 gccgccctgc cctccgccct ccgccctccg ccctccgccc tccgccctcc gccctccgcc
     6361 ctccgccctc cgcaggacaa agcccggctc acccgtctga atgaacacat gggtgttcgg
     6421 caggtgagaa gcccacgagt gttcggcagg cgaggacacg tcataggaac acggcgctgg
     6481 tcgccacggc cttgacctcg cccctcggcg cccggcacgg caagccgacc caggactgac
     6541 tggacctcat cggccaggtc tacgcgcagg aggagcagaa cgcccgctcc accaccgact
     6601 gctccaagcc cccggacgac gccgccgagc cccgccccga ctccgcctac acgggcacct
     6661 accgcaacgc ctactacggc cccctgaccg tcaccgagtc ggaggcgaac tcgccctgcg
     6721 tctgggcccg aagccgatga cgttccgtct gacccactac gacggcgaca ccttctcctt
     6781 cgaaacggtc ggcgagaacg cgagcggccc ctccggcgtc acgttccgcg gcgaccaggg
     6841 cggcacggcg acacaggtga cgatcggggc gttcgacaaa ggcggcttgg gaacgttcag
     6901 gcggggatag ggggttgacg ggctagcgag tcggcggggc ggcggtcacc gcgtcgacga
     6961 gttcggccag cgcctccgcg agggcatcca gccccggccc cgccgggccg cccggctcgg
     7021 tcatataggt gtcgcggcgg atctcgatca tcagggcgct cacccggggg tcgtttccgt
     7081 agtacttcag cgggatgtac gcccccgcga acgggctgtt gactcccgtg ccgccgaagc
     7141 ccgcgaacgt ctcctcggcg cgggcgagca ggtcgggcgg ggtgtggaag gggtcgcggc
     7201 ccaggcagat gggcggtcgg gggccgtcgc cgtggagttc gtagggcagg ggggcgctcg
     7261 gataggagtg aacgtcgatg atcaccgccc ggcccgcggc ttccagacgg tcggtcaccg
     7321 cgtcggtcat ggcagcggcg tacggatgga agtaacgctc gaggagcggt cggccgtcgt
     7381 gatcggcggg gcggaggtcc tccccgtgcg tggtccgtgt gtagaccgcg cccatgccgg
     7441 cggccagcat ctcctcccgc tcgtcgggga agcgctcggg gtcgacgacc agacgggaca
     7501 gccggttcac gaacgtccag ggccgggtcg ccgaccgggc ggcggcttgc tcggcgatcc
     7561 ggtccgtgtg cgtgtcggtg atgtggtcca actcccgtgt cagagagcgg tcgttgagaa
     7621 gaatttcggc gcgtacggcg gccggaatct tccgtgcacc gtgtggcgcg tgcaggatga
     7681 cgggggagtc cggcgccccc ggggtgagcc ggtggggggc cgttggatcg ttcatcaagg
     7741 gtcctcgctg ggggtcggat gcgcgtgccg cacgcgttcc agtgtcttcc tgtgtcgtag
     7801 tacatcccgg cggcgggtgc gtgaggactt gggcccgcct cggacacggc cgcgtgacgc
     7861 gggtgaaaca gctcgtccct aatttctgtc gcccgacagg aattcgccct tcgcgcgccg
     7921 cgtgtgcgaa agctcgcgcc gcttgtgtga aagcaggttg ccgccatgac gagcaccgcc
     7981 tccgccgatg tccgcccgga tccgccgcac tcccccgacg accgctccct gaccgcgttc
     8041 ggttaccgcc aggaactgca ccgcagcctg gggcggtacg cctcgttcgc cgccggcttc
     8101 tccttcatct cggtcctcac cacggtcttc cagttcttcg cgttcgggta ctcgttcggc
     8161 ggtccggtct tcttctggac ctggccggcg gtgctgctcg gccagttggc ggtggccgcc
     8221 tgcttcgcgg agctggccgc gcgctatccg ctgtcgggcg cgatctacca gtggtcgtca
     8281 cggctgtcga acctcacctt cggctggttc gccggctgga tcatggtgat cgggcagatc
     8341 gtggtggtcg ccgcggccgc actcgcgctg cagatggtga tgcccgcgat ctggtcgggc
     8401 ttccagctcg tcggcggcga cccgaccccg accagcgcca ccggagcggc gaacgcggcc
     8461 gtcctgggcg tgatcctgct gctgctcacc actgtcgtga acgtgctcga caaccgcgtg
     8521 ctgtccctgg tcaaccgggt cggcgtcacg gccgagatca tcggcgccgc gctgatcatc
     8581 gtgctcctgc tgacccacgc cgagcgctcc cccggcatca cgttccacac cgccgagggc
     8641 agcaccgggc tgctcggagc gctgctggtg ggctcgttca tggcggcgta cgtgatgatc
     8701 gggttcgaca gcgcgggcga gatgagcgag gagacccgcc atccgcgccg caccgcgccc
     8761 cgcacgatcc tcaccgccct cggcgcggcc ggtctgctcg gcggtctgat cgtcctcggc
     8821 ggactgctcg cggcgcccag cctcaccgac ggcaagctgg gcgtggacgg cctgagttac
     8881 gtcctgacca gcagcctcgg cgacggggtc ggccggctgc tgctcgccga cgtggtggtg
     8941 gcgatcacgg tggccacgct cgccatccag acgtccgcgt gccgcatgct cttctccatg
     9001 gcccgcgacg gccaactccc cttcgccaca aggctcgcca gggtcaaccc ccgcaccggc
     9061 atgccgagcg cctgcgccct ggtcgtaggc ctcctcgccg ccgcgctcct cctcctcaac
     9121 ttcacctcac cggacgcgtt cctggccatc ggcaccacct gcatcgtgat gctgtacctg
     9181 gcgtacgcga tggtcaccgg cccgctcctg gtacgacgtc tgaagggcgc cttcacgacc
     9241 gacgacaccg acgagaccgg caagcccctc ttcaccctcg gccgctgggg catccccatc
     9301 aacgccttcg ccctcctcta cggcctcttc atgaccctca acctggcctg gccccgcgcc
     9361 gaggtctacg acccgtcagg cggacactgg tggttccagt ggttcacggt gctgttcttg
     9421 gtggtcacgg tggggctcgg agttctgtac cggctgacgc gcgcacgacg cgtgcactct
     9481 gccgagtgag cctgatccgc gatccggttt cagccaggcg atccttacgg cgcctccagg
     9541 tggtccgcgg tggccgatcc agcggggtgg ccttgcgggc ggcccgttgg acaagcccgc
     9601 cgcattggcg agacttcgac ctggctcaag gccgaccgcc cctgcctgta tccagcacga
     9661 aatccgatgc gacagggaca atcgatgctg ctgcgagggg aaacggcttg agagtccttg
     9721 ccattgtggc cagaaccagc cattccttaa agggaccgcg catcgcacca taaggtgtat
     9781 gagtagcgac acctgcacat ggaatctgtc agtgccgagt gtgttgtgcc cttttccagt
     9841 cacatacgac gagactgccg cgcgcagggc ggacgaggag atcgctgctt gggcgctgag
     9901 ccttgatctc ttcccggggc agcgggccga gctgaacgga taccggttcg gcacgttcgc
     9961 ggcgttgacg caccctgacg cggtcgacca cgatcacctg atgctcgcgg cccgcaacat
    10021 gaccgccctg ttcgccgcgg acgatcacta ttgcgacgag aaaatcgaag gcgtcagcct
    10081 cgccatgagc gcctcccggc tcgcggggtc gttgaccgcc ctggagaacg gatcccggct
    10141 gcccgactgc ccctcgatcg agggctttgt cggcagtgac ccagtgacgc gtgcgctccg
    10201 cgcgaccgca gaacacatca cacgcctggg cacgccggcg caagtaggcc gtctgcgcca
    10261 cgagacgatc gccacgttcc tggcgatggc ggcggaaaac gcctggcgta tcgccgggca
    10321 tgttcccgat cccgcggagt acctggcgca tcgcaagtac aacggggcca tggcctgcct
    10381 ggtactgatc gatgccgtcg gcggctacga actgcccgta cgcgactggg aagagcctgg
    10441 tgtccggtct ctttcgctcg ccgcctcatt gatgatcatg ctggtgaacg atctgtactc
    10501 ggtcgccaaa gaaagcgccg acatcggcag ccacagcttg cccaccgtgc tctccgcacg
    10561 ccacggatgg tctctcgaac ggagcatgtg cgcgaccggc gaactccacg accgcctcat
    10621 gcgtgagtat ctgcgtctgg aacccgacgt cgcgcgccac gcctcacccg aactcgcccg
    10681 ctacctcgcc ggactgcggc actggatgcg gggaaatctc gaatggcaca ccctcaccgg
    10741 acggcacaac cgtcgcgcgg gacgccctac ccccaggacc gggcctcatg gtcccaccca
    10801 tcaccggatg agggccgacg tgcactactc ggccgctggt gtctgtccac actgcggaga
    10861 ccgccacaac gcggccacag cggttgcgta gacccaccac gaccgggcga tgagggccgg
    10921 cccggcatgc cgcgcccctc gtatgcttga tcgtgatgag acgccgtacc ccgcccccgc
    10981 cctctcccct gccgcagcgc gacggggtgg atccggtgcg ggtgcggttg ccggccgggg
    11041 acgcgtgggc gaccgtgcgg gatcatctcg tggcgcggct cgcggccggg ccaggggtga
    11101 tcgacggaat gctcgacgcg gggcggatcg tggacgtcac cgggcgtccg gtgccgcggg
    11161 acatggcgta cgtgccgggc atgttcgtgt ggttccaccg ggagctgccc cacgaggagc
    11221 aggtgccgtt cgaggtcggc gtcctttacc gggacgagca cgtggtggtg gccgacaagc
    11281 cgcacttcat ggccaccacc ccgcgcggca gccatgtcgc cgagacggcc ctggcgcggc
    11341 tgcggaggca gctgggcatc ccgacgctgg gcgcggcgca ccggctggac cggctcacgg
    11401 ccggggtggt gctgttcacc gtgcggcccg aggagcgcgg cgcgtaccag tcgctgttcc
    11461 gggacaaacg ggtggcgaag gagtacgagg ccgtggcgcc gtacgacccc gtgctggtcc
    11521 tgccccgcac tgtgcgcagc cggatcgtca aggaacgcgg ggtcgtggcg gcccgcgagg
    11581 tcgaaggcga gcccaacgcc gtcagccggg tcgagctgct ggagcaccgg aacgggcgtg
    11641 cccggtaccg gctgctaccg cgtaccgggc agacgcacca actgagggtg cacatgagcg
    11701 cgttgggggt gccgatcctc ggcgatcccc tctatccgac ggtcaccggg cccgtgccga
    11761 ccggtgactt ccggcgtccg ctccaactgc tggcgcgggc cctggagttc accgacccgg
    11821 tcacggggcg cgatcaccgg ttcgtcagcc cacgggtgtt gcgggcctgg tcgtcgtatg
    11881 aggagtgggc ggggtagccc cggtggggcg gggtagcccc ggtgcccggt cggctcagtt
    11941 gcggcgccac cagcgcagga gacgccggta caggcctggc cggcgggccg gttcgggcga
    12001 cgccgacgtc ggcgtgggct catcggccgg aaccgcgggt tccgaagccg tgggctgtga
    12061 ctgctccgtg ctgacctgcc agttgttcgg gcgcagcggc gccaccggct tgacggtggg
    12121 ccgctccatg acctcctccg gggtcttcgg ctcgaacttc accggcagtt ccaccaggtg
    12181 ccggttcccg atggacgacc gccagcgcag ctcgtgctcc ccgcaggcga gttggatgtc
    12241 cggaacccgg gccagcagcg cctcgacgcc gacgtcggcg atggagcggc cgatgtcctg
    12301 gcccggacac tcgtgggggc caccgctgaa ggccaggtgg gcgcggttgc cctgcatgtt
    12361 ggccttgagg tcggggcgta cgcgcgggtc gacgttgccc ggtgcgatgc cgaggaggag
    12421 tccgtcgccc tgacggatgc gctggccgcc cagctcggtg tcctgcttgg cgaagtaggc
    12481 gaagacggtg ctgaacggcg gctcgtccca cagggactgt tcgaccgcct cgggcacggt
    12541 catctggccg ccgttcagct gggcgcggaa gcccgggtcg gtgagcacca cgcgcagtac
    12601 gttggcgagg aggttggcgg tggcctcgta cgcggcgatc aggacgaccc gcaggtgctg
    12661 gccgatctcc tcgtcgttga gccccgccgg gtggttgatg aggtggctgg tgaagtcgtc
    12721 ctggggctcg gcccggcggc gggcggtgag ccgcatcagg acatccatga cgtactggtt
    12781 gctggcgatc gcggtctcgg tgcccttgag catgtcgcgg gcggcctgca cgatccggtc
    12841 gccgtactcc tcgggcatgc cgaggatctc gcacatcacc gccatcggca ggtgctcggc
    12901 gaactggctg accaggtcag ccctgccgtc ctcgcagaac tggttgacga ggtgctgggt
    12961 cgcacggttg atggagcggc ggatgctccg gtagtcgatg gtcgacatgg cgccggtgac
    13021 cgccccgcgc agccgcaggt gctcttcgcc ctcggcgtga cagcagatgg gctgccaggc
    13081 gaagtgcggc atgagcgggt ggtcgggctt gaccgtgccg tcctgcatgg gggtccacaa
    13141 ccggctgtcc ttgcagtact gcgagggggt gctcaccatg tgcaggttct cgccgtggcc
    13201 gagcaccacc cagatgggca cgtcgtcgtg gagcagtgcc ggggccaccg caccatgttc
    13261 ggcgcggagt ttctcgtaca cggctcccag gtcctccgcc tccgggccgt acagccggcg
    13321 caggctgccg gggccattgc cgtgggcggg gcaaccgggg ggcggaccga gcttggggtc
    13381 gtccgtactg gtcggggagt gggtttcagg cgtcacgaat gtcgctccga actgaagtgg
    13441 atccggtgtc tggggagttg gtgagcgacc gggaggggac tggcgtgcgg gacaacacgg
    13501 ctcccggtcg tgggactcgt acggtgtgtg gctcagggaa ctcgtggaac ccgcgcgggg
    13561 ctcatgtcga cgccgccgac atcgccaggg agtgcaggaa gctcatcagc gtcatcagga
    13621 cgtcccggct ggacgcccgg cgccgtgcgt cgcagcggac gatgggaatc tcctccgcga
    13681 ggtcgagcgc ctggcggagc tcgtcgaggg catagcgagg cgcgtccggg aagtcgttga
    13741 cggcgacgac gaagggcaca ccgcgctcct cgaggcggcc catgacgtcg aagctgacct
    13801 ccagccgacg ggtgtcgacc aggacgaccg cgccgagggc gccctcgaac agtccgttcc
    13861 acaggaacca gaagcgctcc tgccccgggg tgccgaacag atagagcacc agctggtccg
    13921 tgatgctgat gcggccgaag tccatggcca cggtggtggc cgtcttggac ttggagccgt
    13981 agttgtcgtc gactccgatg ccggcctgcg tcatggtctc ctcggtcgtc agcggtttga
    14041 tctcgctgac ggaccccacc atggtcgtct tgccgactcc gaaaccgccc acgatcacga
    14101 tcttcgccgc ggcctgtgcg gtgtgcggca ggtggtcctc ggtccgtgga cccgtgatgg
    14161 tgtcagagct tttgaagtcc atgcatcacc gcttcgagga gggaacggtc tgctcgcgcc
    14221 tgccggatga ccggtgcgcg cgcctgtacc agttcggccg tcagcagctc ggtgagcagg
    14281 acggtcacca cgctgatcgg caggttgaga taggccgaga tctcggccac ggagagggga
    14341 gcctggcaga gccggagcag cgccgactgt tccggagcgg cggagcgcgg tggatcggcg
    14401 cgcgccacga tcaacgtgac gaggtcgatc ggggcccgct cgccgtcctc tccggtgagg
    14461 atgtagagcc gctcgggggg gcgctcccct tctccgtcct tgggcccctc caactccagg
    14521 ggcggcggag gtggctcctg tttggggtgg cgtcgtcggc gttgcggagg agtcatacgg
    14581 tctgcccgtt ccgccgcggc ggactggtca gatgggagcc gatgcggtcg acgaggtcgc
    14641 gcatacggtt gctcatcagc ccgggctcgg cgatctcgtt ggcgagcacc gcgaggtagg
    14701 cgttggatcc ggcggccatc agatagaagt agccgccgtt gatctggatg atgaccatcc
    14761 gcatctcgcc gtcgctctgc ggaatctcac tggcgacggc gccggccagg ctctgcaggc
    14821 ccgcgcaggc ggcggcgacc cggtcggcgg cgtccgggtc accgccgtag cgggcgatgc
    14881 gcaggccgtc ggcggagagc accacgatct gctggatgcc cggcacgccg tcggccagat
    14941 ccttgagcat ccagtcgaaa ttggctcgct gctggatcac ttgagatccc cctcgtcgcc
    15001 ggcctcgctg tgggccgact cgttgttcgc ggtggaagcg gtgaacccgg tggccgcgct
    15061 ggactcggcc ggggcggccg cgtcgttcgg gttcctggtg gcggccttgg gatccgggtc
    15121 gcgcttgagt ccctccatga acgcctcgac ccacaggccg ggaggcggca gttccttctt
    15181 cggttcgggc tcgggctgcc acacgggcgc ggcggccatc gcggcttcgg ccgctgcctc
    15241 ggccgcggct gcctcggcgt accgctggct gagcgggatg gtcatccggc tgcggcgctg
    15301 cggcaggccg ttggccgtcc actcggtgac gacggggacg tcgtcctcca tgcccggggc
    15361 catctcctcc gcggagctcg ggatccgcgg tccggtggtc gggcggcggc gcttgggctt
    15421 gcggtcgggg ccctcgacgc ctccggtgtc catggtcggc acggcggcgg cgccgatgcc
    15481 gtgggcgaga ccgggtgcgg gctcctcggt gagcatgttg cgtggtacga cgaccacggc
    15541 gcggacccca ccgtaggcgg acggcctgag cgagatcttc atcttgtaca tcgtggacag
    15601 tcggcccacg acggcgaggc cgaggcgcgg gctgccgccc atgtcctgga tgtcctcgcc
    15661 ccgctgggcc tttttgagca tgtcctcgac cttggcgcgg gactcctcgt tgaggctgac
    15721 gccgccgtcc tcgatctcga tggcgatgcc ggtctgcacc tcgatggcgg tgacgtgcac
    15781 cttggtgtgc ggcggcgagt agcgggtggc gttgtcgagg agttcggcgc aggcgtggat
    15841 gaccggttcg acggagacgc cgttgacgtt gaccttggcg atcgagtgca actcgatgcg
    15901 gcggtactcc aggatgcggg acatggcgcc gcgcaggcag ctgtagagcg ggacgggctt
    15961 gggccacaca cggccggggc ggctgccgcc gaggacggcg atggagtcgg cgagccggcc
    16021 gatcagcgcg gtgccgtggt cgatgcgcag caggtcgtcg aagacctcag ggttgcgccc
    16081 gtggtcctcc tccatctccc ggagttcctt gttctgctgg tgcacgatcg cctggacacg
    16141 tcgggcgatg ttgacgaagg aacgctgcga ggagtcgcgc atcgctgtct cgcggtcgat
    16201 gacgtcgagc accgtgtaca gcacgtcacg ctgggacttg ggaagttcgc gccactcggc
    16261 gtcaccgtcg atgacatgac gaatcacctc tgagggggat tctccgccgc gcagtcggta
    16321 cagcgcggcg ggcaggatct ccttgcccag ccgggtgaac tcctggtcgt gggcggcgat
    16381 gcgctgttcg agactggcgg tccgccgccc ttgttcggcg cggagttggc ggaccgtacg
    16441 acggcgtccg cgcaccgcga tgaccgcgac cgcgaccagc aggagcgtcg cgacggtgcc
    16501 gcacaagccg acggcgagcc ggaccgaccc cgtcaccagg gagacggtgg tcccggtcgc
    16561 cgcggccatc agtatcgccg gtagcaacag cacgcgcacg tcgggaagtt cacggccacc
    16621 gggaggcgat tgaacactca ccatgtatgc cctctaaaga cagatcggct gaaggtcagg
    16681 gacttatggg ggacttgctg atggttcttc cgcagttcaa actgcgtctt cggtattttt
    16741 tggaacaagc gcacgattac atctcaactc ggtgcgctgc gggcgagctt agtccgaccg
    16801 gatcatcgct gtgtcatatt cagcaaccgc ctgaaaccac cctcgcaact ggggtacgct
    16861 ctggtcgttt acacacaggg cagccgttcg aacgcattgc gtaacggcga acgagcgtac
    16921 gagaatcgcc ccttgacagg gtgagacggg acgcaaaggc gcaggtgagc cgcgctccgg
    16981 ctcagacccc ggcgatccgc aacgcggcat ccgccgtggc gtcggcgaac gcggacacag
    17041 gccggtcggg gtcggagcgg tggacgagga tgacaccctc gatcaggccg aacaccaggt
    17101 ccgtacgcag gtccagctca ctcttggcga gcgccgcgcc cgccgccgtc gccgcgatca
    17161 actgccgata ggcgtccttg agttccgccc gtacggcgtg gaagcccgcg aagcgttcgg
    17221 tgcggacctc cgggaggagg tagagcccgc cgaggttgtg cgggccgccg cagagcagtt
    17281 ggacgtcggt gcggcacagc tcccacagcc ggtcctcggc cggggtcgcg tcgtccgcga
    17341 gcaggcggcg ggccagggtc agcgaggggg tgaccgtcga ctccagcaac tcggcgagga
    17401 gttcctcctt gcctgagacg tagtggtaca tcgacgcctg tcgcatgccg gcgcggtcgg
    17461 ccagggcgcg ggtggaggtg gccgcgtagc catgagtcgt gaacaactcg gcggcggccg
    17521 cgagcagttc gtcacggggc gagaggccgg tgtcgggccg gtgttcggcc cggggcctgc
    17581 cgacctttcg cccacccgtg ccacctgcgc ttcccatgcg ttcgatcctc gcacatgggg
    17641 cgctggagcc tttggacggt gggtacgcgc gggtcctatg tggccggtcg cgccgttccc
    17701 cgcgcccctt cgtggcacca ccctggtgag ggttcgaggg gcggccccgt gagcgttcga
    17761 taaccgaccc ggaacctcgg cgtcacgccc tcgacgtcac ccactcatag tttctgtcga
    17821 gcgacagaaa tcaccggagc acccggaggc cccgcgatgg cgacagcgac gacgtacgga
    17881 gcacgtgatc acgccagggc gcaggagggc acccgcaccg aggcgatgcc cgtcgtaccg
    17941 gcgagcagtt ggccggaacc cccctgtgag gcgagccgcc tggtgtgggc ggagacggtg
    18001 gcgggcggca actacacgca cagggtgctg gcccgcggca cggagttccg cctgaccgat
    18061 acgcacggcg acgcctgcgc gcatctgctg ctccaccacg ccgaccggcc ctgggagcgg
    18121 ctgaacgtcg cggacacggt caaggtccag tggaacgcct acctcggcga gggcgtcctg
    18181 ctcctgtccg accagggccg cgtcctcgcc tcggtcgtcg ccgacacctc gggccggcac
    18241 gacgcgctgt gcggcacctc cactctcgta cgcaacaccg agcgatacgg ggacggcacc
    18301 ccgcagtccc cctcccccgc cgggcgcgag ctgttcaagc tcgccgccgc caagaacgga
    18361 ctcgacccgc gcgatctgcc gccctcgctc tccttcttcc agggcgtgcg ggtacgcgac
    18421 gacggcaccc tcgacttcac cggctccgtc ggccccggcg gcagcgtgac gctgcgcgcc
    18481 gagcaggacg tgaccgtact gatcgccaat gtgccgcatc cggtcgatcc gcgcccggag
    18541 tacgtcagca ccgcgctgga ggtcctcgcc tggcgcgccc ggccgacccg gcccggcgac
    18601 gccctgtggg acgccacccc cgagggccgc cgcgccttcc tcaacaccgc cgagttcctc
    18661 gccgcgaggg ggatcgcgtg aagaccgtgg tcgttcccgc ccgcgccgcc tggtcgtccg
    18721 tgatccgcgc cggcgccgcc ctcaccatca ccgatctgca cggaaaccag gccgtcgact
    18781 tcctcgtgta cgacgcccac gacacgtccg tccgctacag cgcccccgac accatccacg
    18841 cgcagggcgg aatcttcctc accaccggca gcgtgctgat gtccaacgag cacactccgc
    18901 tgatgaccgt ggtcgccgac gacgtgggcc ggcacgacac ggtcggcggc gcctgctcca
    18961 aggagtcgaa caccctgcgg tacggccacc acacctggtc gcagcacgcc tgcgtggaca
    19021 acttcctcgc ggagggcgcc aaacacggcc tgggcaaacg cgacctcgtc tcgaacatca
    19081 actggtacat gaacgtgccc gtcgagaagg acggcaccct cggcatcgtc gacggcatct
    19141 ccgccccggg cctctccctg accctgcgcg ccgaacgcga cgtactcgtc ctcgtctcca
    19201 actgccccca gatcaacaac ccctgcaacg gcttcgaccc gacggcggtg gagatgacga
    19261 tcaccgaggc aggcggcgca tgaccttcga caccctgctg gtcgccaacc ggggcgagat
    19321 cgccgtacgc atcatccgca ccgcccgcga actcggcctg cgcacggtcg cggtgtactc
    19381 cgacgccgac cgcgccacgc cccatgtccg gctcgccgac gaggcggtac ggctcggccc
    19441 ggcgcccgcg aaggagtcgt acctcgacgc ggacctggtc ctgaaggccg ccaaggacgc
    19501 gggcgcgggg gcgatccatc ccggctacgg cttcctctcc gaggacgcgg ccttcgcccg
    19561 ccgctgcgtg gacgcggaca tcgtgttcgt ggggccgacc cccgagcagc tggagctgtt
    19621 cggcacgaaa cacacggcgc gggcggccgc cgaggccgcg ggcgtccccc tgctccccgg
    19681 caccgggctg ctggcctcgc tcgacgaggc cctcgaccgg gccgcggcca tcggctggcc
    19741 ggtgatgctc aaggccaccg gcggcggagg cggtatcggt atggcggcat gtcgatccgt
    19801 cgatgaactg accgaggcct gggagcgggt gcagcgcgtc gccgccgctt cgttctccgc
    19861 ggcgtcttcg tcaggtgtct acctcgaacg cctcgtcgag cgggcccgcc atgtcgaggt
    19921 gcaggtcttc ggcgacggcg acggcctcgt cgtcaccttc ggcgaccgcg actgcaccct
    19981 tcaacgccgc aaccagaagg tcgtcgagga ggccccggcc ccaggcctcc ccgaccatgt
    20041 ccgcgcgcaa ctgaccgcct ccgcccgcga cctgtgcgcg agcgtcgagt accgctccgc
    20101 cggaaccgtc gagttcgtat acgacaccgc acgcgaggag gcgtacttcc tggaggtcaa
    20161 cacccgcctc caggtggagc atccggtcac cgaggagatc tacggcgtcg acctcgtcgc
    20221 ctggatgctg cgcctggcgc gcggcgactc cgccgtcgtc caggccccgg cgcaaccccg
    20281 cggccacgcc gtcgaggccc gcgtctacgc cgaggacccg gcccgcgaac accggccgag
    20341 cgcgggcctg ttgacccggg tcgagttccc gcaaggtgtg cgcgtggacg gctgggtgga
    20401 gacaggtacc gaggtcacga cgtcgtacga tccgctgctc gcgaaggtcg tcgcgtacag
    20461 ctcggaccgc gcgcacgcgc tgcggcggct cgacgaggcg ctggccagga cccgcgtcga
    20521 cggcatcgag acgaacctgg ggctggtccg ggcggcgctc acacaaaagg acttcgagca
    20581 ggccacccac tccaccgcga ccctggcatc ggtgagcgac ccgaccccgc gcatcgaggt
    20641 cgtctccggc ggcaccctca ccaccgtgca ggactggcca ggccgcaccg gctactggca
    20701 ggtcggcgtg ccgccctgcg gccccatgga tgacctgtcc ttccgcctgg gtaaccgggc
    20761 gctcggcaac tccgacggcg cccccggcct cgaatgcacc ctccaggggc cgtcgctgcg
    20821 cttcacccac gccacgaccg tctgtgtgac gggcgccccc gcccccgtga ccgtggacgg
    20881 ctcaccggtc c
//
