LOCUS       NZ_CP022161            27455 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5876606
            Orig. end                         :: 5904061
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27455
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aureonuclemycin"
                     /region_number="25"
                     /rules="(her4 and her5 and her6 and her7)"
                     /tool="antismash"
     cand_cluster    1..27455
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(her4 and her5 and her6 and her7)"
                     /kind="single"
                     /product="aureonuclemycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27455
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17455]"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17455
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
     gene            complement(275..814)
                     /locus_tag="CES90_RS26255"
     CDS             complement(275..814)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004693.1"
                     /locus_tag="CES90_RS26255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="WP_189783799.1"
                     /transl_table=11
                     /translation="MTQPKRPPLPHDFHPVVPSFTVTSEDVEPGATLKDAQVYAGGNTS
                     PQLRWEGFPAETKSFAVTCYDPDAPTGSGFWHWVLFDIPVSVTELPAGAGSGKFEGLPE
                     GVVQVRNDYGTKDFGGAAPPPGDPAHRYVFTVYSVDQEKLGPDSDASPAVVGFNLRFHT
                     LARAQLIGEYAAVAEK"
     gene            complement(857..1639)
                     /locus_tag="CES90_RS26260"
     CDS             complement(857..1639)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522080.1"
                     /locus_tag="CES90_RS26260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sporulation protein"
                     /protein_id="WP_189783800.1"
                     /transl_table=11
                     /translation="MGFKRLLASLGAGGASVETVLTEVNVVPGGVVQGEVRIQGGSVDQ
                     QIEALSVGLQAKVEVEGQDAEYKQDIEFTKQRLGGAFELKAEAVHVVPFGLEIPWETPV
                     TTIQGQTLPGMNIGVTTELEIARAVDSGDLDPINVHPLPAQQAILDAFVQLGFRFKNAD
                     LERGHIRGTRQKLPFYQEIEFFPPQQYHGLNQVELSFVADEREMDVVLEMDKKPGLFSE
                     GSDSFRAFKVGLQDYQGTDWAAYLNQWLSEVGSKRSWF"
     misc_feature    complement(1704..1717)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            1839..2480
                     /locus_tag="CES90_RS26265"
     CDS             1839..2480
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0003905 - alkylbase DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381068.1"
                     /locus_tag="CES90_RS26265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_189783801.1"
                     /transl_table=11
                     /translation="MIAIPDRTPLAREFFDRPVLEVAPDLLGRVLVRVTPDGPIELRLT
                     EVEAYDGANDPGSHAYRGRTARNGVMFGPPGHVYVYFTYGMWHCMNLVCGPEGRASAVL
                     LRAGEITEGAELARKRRLSARNDKELAKGPARLATALDVDRALDGTDACALDDPALTVL
                     TGTPVSPDQVLNGPRTGVAGDGGVHPWRFWIANDPTVSPYRAHVPRGRST"
     gene            <2807..3286
                     /locus_tag="CES90_RS26270"
                     /pseudo=""
     CDS             <2807..3286
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538739.1"
                     /locus_tag="CES90_RS26270"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA-directed RNA polymerase subunit alpha
                     C-terminal domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RVEQRTDFDKLIVDVETKQAMRPRDAMASAGKTLVELFGLARELN
                     IDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELLARSEADLMD
                     IRNFGAKSIDEVKAKLAGMGLGLKDSPPGFDPTAVADAFGASNDTDAGFVETEEY"
     gene            complement(3485..3649)
                     /locus_tag="CES90_RS26275"
     CDS             complement(3485..3649)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS26275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189784683.1"
                     /transl_table=11
                     /translation="MRASDEETGPAEAVRAGCGVQRQRRVALDSETAHFVEVGLCLGAD
                     KYLCLGADK"
     gene            complement(3793..4170)
                     /locus_tag="CES90_RS26280"
     CDS             complement(3793..4170)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.5"
                     /locus_tag="CES90_RS26280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_308437876.1"
                     /transl_table=11
                     /translation="MTASSICLYWGGMALNDYADAVVDAVERPQRPGPSGRISRRSALA
                     VASGLTRAGLGLAAVPGRRRGLATEVPLAGLVWAYDLALKSTPAGPAAMAGARAVDVLA
                     GTRSLAPALPRPSWWACTPTP"
     gene            complement(4290..4955)
                     /locus_tag="CES90_RS26285"
     CDS             complement(4290..4955)
                     /EC_number="2.8.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_4: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF036807.5"
                     /locus_tag="CES90_RS26285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfotransferase family protein"
                     /protein_id="WP_189784684.1"
                     /transl_table=11
                     /translation="MVDVIGAGFGRTGTASLKEALEMLGYGPCHHMTEVIQNPDTSAGW
                     IAALTGDASVLPGLVGKYRATQDFPGALLWREMMELYPDAKVLLSVRDPKEWYDSARAT
                     ILNQDLRRHLEQAAEPDARRMADMLLSLTDAMAAKGFRTDLGEQETIAVFERHNEAVRA
                     AVDPEKLLVYEVRQGWEPLCAFLGVDVPDEPFPRGNEAGVFTGKVRRLVAGEADSTVQ"
     misc_feature    complement(5133..5146)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(5864..7156)
                     /locus_tag="CES90_RS26290"
     CDS             complement(5864..7156)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982476.1"
                     /locus_tag="CES90_RS26290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189784770.1"
                     /transl_table=11
                     /translation="MAEDITFWDYSRSQALSRYNGSKIDVREIAVLCGIRKDAESVDTR
                     LPSPDEIAGIHPLALKRPRRWEAAIAAMIYAGSGQLAARQEIIKARELLDRLSRADRSA
                     LSVSRMLALVPTMIAGFRFSRQSEMFNPESNRYLEGARFLSALLEDRPALDVEIGLCAH
                     RAGVTDPVLPEHVSGPGTARMVAFVSALMDNSLARKRTVNVSQQTATDRAASTVNSLVF
                     LHYATEGRVEHLLRILDQHADDLRAALACHNAVSDTEFRFTPLDPFSDLVERDMDEVFG
                     PDWSGAPAEPHWRSGETLHSAVEAAMGTMQRFMRNERHDLDHLLRLHKNGERPSERGAS
                     ALCWFDRYERRPLEVRARYHVAFHHRLALTTLRKDGVGIGMERGWDAYQWLAWSAAYGS
                     PQKAMPLLYARSSTEPASNISLKSFNLRQFW"
     gene            complement(7235..8509)
                     /locus_tag="CES90_RS26295"
     CDS             complement(7235..8509)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009343476.1"
                     /locus_tag="CES90_RS26295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_189784685.1"
                     /transl_table=11
                     /translation="MSAAPSAPPRPGRLSTALGLPRLGGQRLLLAAVLVDSTGSGLAVP
                     FLLLYLTGQDRMTAATAGTLLTVAGVAALAAGPLSGPLMDRWSPRRLVQTAHVLRATAF
                     LGYMTTGSWPAVLVLATLAALGDNLFWPANRAFLARRCRPDELLRWYGLERTLRNVGMA
                     VGGLAAGFLAGLGPTGLRLVMAGNAVSYALATVLIALLPTAARPPSPGPAPAVPRPRPA
                     RPRPDRAYVTMVAANTLLVLVSAALPVLVPLYVVQWLHQPSWVVGAVFALNTALVTAGQ
                     ALVVRRLERREYLRVLQWAAMLWSAAAVLFGTASGLPRTAVLPLLAVAVLVFTAAELMH
                     APTSDVVAVRMAPEDVPGRHLGLHQLSWGVGSAIAPLVLTGALTLGPWWPWALLATSAA
                     AATAALAAVRRAVGQVRQDGDGPGD"
     gene            complement(8797..9885)
                     /locus_tag="CES90_RS26300"
     CDS             complement(8797..9885)
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321745.1"
                     /locus_tag="CES90_RS26300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase"
                     /protein_id="WP_189784686.1"
                     /transl_table=11
                     /translation="MNEHTHPHSPHDIISLATAFWTSKALLSAVELKVFAALAEKPRTA
                     DELRADLSLKGRGAPDLLDALVSVGLLDRSAEGIYQNTPLADTYLNPQRPATDITGYLE
                     YLNSAFPAWSQLSAAVRSGGRLNRNEALAAAADGGRETVRGGVLLEGDPTADTFGEAYS
                     TPEQVTGFVRSMTGFSLGAHLALTTRFDWSAARSVVDVGCAEGAFLAHILTAHEHLEGT
                     GFDLPQVADSFAAYLGDSPAVGRARFVAGDFFHEPLPSADVIVMGHVLHDWNLDIKKML
                     IRKAYEALPPSGSLLIYEMLIDDDRRKHTTGMLTSLNVSLASAGGLGYTGAEASSWLTE
                     AGFREVTVRHLDGPDHMVVGVK"
     gene            complement(10001..11269)
                     /locus_tag="CES90_RS26305"
     CDS             complement(10001..11269)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321756.1"
                     /locus_tag="CES90_RS26305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_189784687.1"
                     /sec_met_domain="her6 (E-value: 7.5e-221, bitscore: 732.6,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHVCFAIPDDEFERDFLQLPLDVANACAALRAEGIGVSVWDNRL
                     TDTPPDTGPDPDIVVVVTAIADRAQCYPLVLHPVRELVEGSRRQWPGATVLACGPHATH
                     LPEATRAELGADFVARGEVDSAAIQAVRDLTAGRPALPVMPLVDTYPQLAPEQWPLPAY
                     DLFDLTSYTAEVFMDGRVRRGSCGMVLGVRGCTYGCTFCHLPFGTRMRPQPVERTLAEI
                     AAMREGGVDFVFFLDYVFGLHPTFYQDLCRSLTGQGLGWTGQSRAEVVLRTDVAQWAQA
                     GCKGMWLGAESPGIAETPVGKRVKPGVTDAAVRTLQDVGITPFAFVLLGLPDDPACQNG
                     ELLDWATNLPGYFGLNQLFLRPGTTLYEQLAPRYNDGRMPSTWSEVEAVTRRYRESYPV
                     DLNELWDRLVRLPNYLGNAMAAL"
     gene            12253..13920
                     /locus_tag="CES90_RS26310"
     CDS             12253..13920
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321747.1"
                     /locus_tag="CES90_RS26310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189784688.1"
                     /sec_met_domain="her4 (E-value: 1.8e-280, bitscore: 930.5,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFAESESLGVAVEAGTATDRGAGRYEILDGRMTPQDVDETVRSV
                     LRGEGVPLRDLTEPEPGGHLIDLDGTLVQLRSRQIADAAPDTLAPIDPPAGRTQVLLAA
                     AGPLSGRAEAVFDRLVEALTLRGRCYTAAEIDSIVEGMPLVARYATEEPAFRDWALIFR
                     DHYVENSVGFLLGMERAGIDREWIFALNKGDRTLHRDRVHAWFLHRGYQSDTLDNSVIN
                     GSADTTARAYALAVNERVDDFVRRAHEAGRKVLVVDDGGLLAQGYGADGILDERIDGAL
                     ELTVSGLKRIAGAPGELTIPVLNMARSRLKSMLGYNEIADSCVRRLRAVLPGEKFIGRH
                     VLLLGYGTLGARVAHALRALGCRVAVVDTDILALITAAEHGYETYISAGEALNAHAPFL
                     IIGNTGELALTHADLPLLPDGVHLAGFATKDFSLLSEGFEGLRSTVIPQVGVRYALPTG
                     TTATLLGDGRSLNLFEYEGIANHGYDAYRAGTLIAAKTLCREADRLGPGLHLEPVDRAI
                     DEAGLFSAYYEEYLASGTRRPAAPADTAMPAAPAPVTR"
     gene            13917..15011
                     /locus_tag="CES90_RS26315"
     CDS             13917..15011
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357384.1"
                     /locus_tag="CES90_RS26315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_189784689.1"
                     /sec_met_domain="her5 (E-value: 5.4e-172, bitscore: 571.1,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2e-05, bitscore:
                     24.4, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRAFGPHVCVIGYGAAGRLHQRLLSDLGFDVSVVDPAPGVPPT
                     AIPVFDGAEQAARHRPVDVWSVCSPTATHVATVADVLAVDPTARLLVEKPLCRTWEIPE
                     LTSLLDHHPDARLVVMDQYRHSQAMALLRTLRQELAPRHELRAVRVGFGKDRRADIAAG
                     RFVDHDYGVFGYEWLHMLALVRGVLPSGTYDRYMCTGPEEWGLRVATDPELTSTAAHEQ
                     AVAEGVDIELYSTIVGSDPSGQVAVPTWFSLPAAAGESRQRHVEVLTGPVCFELDLDPV
                     TLSRGTRLPRNTHRLVVQGPELRREWLIHDSPLDNALRWSVAALLSPAGPPGLDLRGVA
                     RIGLLADTAHPAARPSSVRTELRT"
     gene            15008..16291
                     /locus_tag="CES90_RS26320"
     CDS             15008..16291
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321756.1"
                     /locus_tag="CES90_RS26320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_229914013.1"
                     /sec_met_domain="her6 (E-value: 3.3e-172, bitscore: 572.3,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPLRLCLVVPAGPVDRFVVRVPLDVLAAAAGLRADGHEVTVWDQ
                     RLPDTPPVTEDPDLLVVFTAGVGRARRYPLDLAPVRAATDRARRRFPGARTMAVGPHGT
                     HLPGATLLDLAVDHVAVGEAGSATVHGVRDLGAGTAAPVLYGDLPRPAAPVTVVGNHPR
                     PYPDLDQDRWPMPAYDLVPLERYTAEVVVDGVPRPGPAGTMLATHDGTFDHPPFGAGPR
                     TRSVDRVVAEVAAQRAAGLPSQSFLDSVFGIDTSYYGVICERLRGQGIDWVARTSTETV
                     LKTEVTRWAEAGCRGMWLRAEPPSGVDAGQPFRDAVLKLRDAGITPFASVLIGLPRDAA
                     RVPDRLVDWAAELPARFGLDLVSPRPGTPLYDRLAPGLNGGTAPATWQEVRDVTRRYRA
                     DYPADLDDLERRLTALPNHLADATALTG"
     gene            16301..17455
                     /locus_tag="CES90_RS26325"
     CDS             16301..17455
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321760.1"
                     /locus_tag="CES90_RS26325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_189784690.1"
                     /sec_met_domain="her7 (E-value: 1.7e-196, bitscore: 651.8,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.1e-22, bitscore:
                     80.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.8e-33,
                     bitscore: 113.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTFGVIGCGSIGGFLARLLTREDKELADRARLAAVAGRDPARVG
                     ALAAEVRCGATDVAGLLARRDVNAVLVCTPSGTHARLAEEALRAGKHVLVEKPVDVTPQ
                     TADRLISVAREAGRTLGVVSQHRFDPAARLARTAIASGRLGRVTSVMTELAWWRGSAYY
                     SSGTWRGTPALDGGGALMNQAIHAVDLVQWLAGPVVEVAAHTARLAHPGIEVEDVATAS
                     LRFANGALGTLLATTAAYPGRTARTAVNGDRGSVVIDDDELAYLHLARHGEDAPAYGAF
                     GTADQSADYAAALVRDPARDASGLLYQPHRDQLLDFCDAVREGRPPLVDGAAGRQAVAV
                     VTAIYASARTGRPQRVDTGTPAGIRGTPRFTKESPKGDQQTTKQ"
     misc_feature    17687..17700
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.49"
                     /tool="antismash"
     gene            17820..20666
                     /locus_tag="CES90_RS26330"
     CDS             17820..20666
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024793.5"
                     /locus_tag="CES90_RS26330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_229914024.1"
                     /transl_table=11
                     /translation="MRTEIRDLFLTPFGDPINLINQRGRIFILQGGPGTGKTFYLEEAK
                     RLAIASDSLCLHATGFREEHEIPFSAFEQFIHVPGIPDTVRSAVWRLVRRTASATPSGL
                     APARLLQDLFSALVAAAKHTGMVILIDDAQYLDADSHSCLLYLARRAQSHNITMVVAYP
                     PDAFCDAIGNRLDLLGLPGACLLKATSLRENDVRTLLERGLGAEGATRLAAPVHRISGG
                     NPALAAALVRDLRVAGGIEPETPVPIGDAFRTAYLAGLARHPCLAKTVQALAVLGDDAT
                     PARAAQLLESCPHEIAKHIAALECAGLLGEGGFRHPAVPGAVLGMLGAELASLHRRASA
                     LLVAEGAPALAVAQHLLAAQERPDVSHVPVLRRAWQQLLVAGQTDRALACLRLADQAEL
                     GEEQRAEITAELVHTLVWVNPLAAEPEVGRLLAAARAGRADCRALRLLVAWLLWFGRHD
                     RAREVLVQLVETCDPSHADDGKRALSTLIGCLWPEVLGDPAVRGYFRTAQDSTLATGYG
                     ATAIPPSRTAVVHSGRLRRLLSPMAATEWNDDHEAAGRRAASADMDARPFWKLDLAAVM
                     ELVQEGETTLADRLCEEKRTRLPADEFPVRHALLAALHGHIRGKLGDPRTASECAQAAL
                     ALLHEQGWGVAVGLPLSVLISAHTLMGDPSRAAHYLERPVPDEMWDSSFGPLYRIALGC
                     YLLETGRPDMALNEFIACAPKGEDRPADPFGCSCWRAHAAEAYLALGEPEQARRMADAE
                     LLQGDRPTDARGRALRILAVVDAPEQRRAHLEEAERTLRGAHSRLPLAQVLAQLSQVDL
                     ADGHTRTARARWKEALSLAAACGVPHRLRPPASPLDEPLAPPQPAWAEGGQPTATGPAP
                     RHTTGAGGLTEAEWRVASLAAARRSNRQIAAQLYITVSTVEQHLTRVYRKLSVRRRSDL
                     PGLLGLQSQEGDQTGFVF"
     misc_feature    17841..17843
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17979..17981
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18741..18743
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20337..20339
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20663..20971)
                     /locus_tag="CES90_RS49885"
     CDS             complement(20663..20971)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (31-62). E-value: 3.3e-08. Score:
                     25.3. Matches aSDomain:
                     nrpspksdomains_CES90_RS49885_ACPS.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013786.5"
                     /locus_tag="CES90_RS49885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_229914014.1"
                     /transl_table=11
                     /translation="MGVDVQGVPGPETVTLCAPALHPAEQAEIAGAPESLRPVAFARLW
                     ARKEAYLKGLGTGIGHGVGARYLGERGGDTAPARPAGWDIRSRADPRGAPWCSGLVD"
     aSDomain        complement(20786..20878)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CES90_RS49885_ACPS.1"
                     /evalue="3.30E-08"
                     /label="CES90_RS49885_ACPS.1"
                     /locus_tag="CES90_RS49885"
                     /protein_end="62"
                     /protein_start="31"
                     /score="25.3"
                     /tool="antismash"
                     /translation="APESLRPVAFARLWARKEAYLKGLGTGIGHG"
     gene            complement(20998..21480)
                     /locus_tag="CES90_RS49890"
     CDS             complement(20998..21480)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS49890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_229914015.1"
                     /transl_table=11
                     /translation="MGARTGAGRWPRPWAHSNDGPTVPDRPGGPGQPDRPRPHRPRHTQ
                     AGADGGDRLGSGLEEGALHVWLLRAAHGAGPLPRSATDELSAREARRAAATARPRHRLL
                     YLSAHIALRRLLAAYTGVPPDRLRLGRARCPRCGGPHGRPVLLGFPCTSPSPTATG"
     gene            complement(21562..23157)
                     /locus_tag="CES90_RS26340"
     CDS             complement(21562..23157)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129830.1"
                     /locus_tag="CES90_RS26340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_373313444.1"
                     /transl_table=11
                     /translation="METEMTTSPQVKAGKREWLGLAVLALPTILIALDMSVLHLAVPHL
                     SADLDPSSTQLLWIVDIYGFLIAGLLITMGTLGDRIGRRRLLLIGAVGFGAASVLAAYS
                     TSPVMLITARGLLGVAGATLMPSTMSLLRNMFHDAKQRNVAISVWMAGFVLGGALGPAV
                     GGVMLEYFWWGSVFLLGAPVMALLVITGPILLPEYRSEQPGRLDFLSVLMLLVGVLPVV
                     YGIKEYASHGIEATSSLILAVGLAICAAFVLRQRNLESPLLDLRLFSSRTFAAALAVLS
                     LSMFVMAGAQFFLAQFLQMVSGYTPMEAGLLMLPISVMMVIGIMASPGLAQKIRPAYLM
                     AGGLAIAAVGLFILSRLTEDSGIGMVIAGGAIMSLGLGPTPALGTGMVLATAPAEKAGE
                     ASAIQETAAELGAALGIALLGAVGTAVYRAQVQDSIPDGTPEAATAAAEDSIGSAVAAA
                     EDLSGDTKESLLDAVRTAFTDGIQISYTASVVIALAIALLVATLLRRVTPTLEEEGEAP
                     QPEQKVTATGDQAR"
     misc_feature    complement(23101..23103)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(23276..23857)
                     /locus_tag="CES90_RS26345"
     CDS             complement(23276..23857)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950145.1"
                     /locus_tag="CES90_RS26345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_189784693.1"
                     /transl_table=11
                     /translation="MSEEKLRLAVLVGTVRDVRLAPVFAGWFLRAARAHGRFEVDVVDA
                     KYIALPLAVDRRSAEISAEPRKVTPVLASADAFVVVTGEYNHSFPAALKNLIDWHRTEW
                     QAKPVGFVSYGGMSGGLRAVEQLRQVFAELHAMTVRDSISFHKATALLDATGRIRDEEA
                     YAPTVKSMLGQLEWWSLALREARDKRPYEA"
     gene            complement(23898..24269)
                     /locus_tag="CES90_RS26350"
     CDS             complement(23898..24269)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189784694.1"
                     /transl_table=11
                     /translation="MAPAAGCALYARLEEPGSYAADALPTLLLFGVGFMLAFGALNMRA
                     SSGLRPADKGVGTAVYQAAVPFGAVVVLVVVALLLGRGDGAGPATGDGLAYQDALLLVT
                     AVAGAGALVALAGALRRSP"
     gene            24283..24597
                     /locus_tag="CES90_RS26355"
     CDS             24283..24597
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CES90_RS26355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189784695.1"
                     /transl_table=11
                     /translation="MSEGAPKRAAVLGSERDDQPQVDVDCVRRPGAAAEGSVAEDVEVG
                     GHLAAYLLGKHCEVSSDQLFEGVGCVVEQDVEIVEHVDEMDCGDIDVPGQCVHRAPWWL
                     "
     gene            complement(25583..26671)
                     /gene="ychF"
                     /locus_tag="CES90_RS26360"
     CDS             complement(25583..26671)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ychF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058470.1"
                     /locus_tag="CES90_RS26360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="redox-regulated ATPase YchF"
                     /protein_id="WP_189784696.1"
                     /transl_table=11
                     /translation="MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVG
                     VPDARLTKLAEIFGSQRILPATVDFVDIAGIVRGASEGEGLGNKFLANIRESDAICQVI
                     RAFKDENVVHVDGKVSPKDDIETINTELILADLQTIEKVLPRLAKESRIKKDVAPKVKA
                     VEEAKEILERGDTLFSQGIVQGGERAELLHDLHLLTTKPFLYVFNVDEDELIDDDFKNE
                     QRALVAPAEAIFLNAKLEADLAELDEADAMELLESVGAEEPGLATLARVGFNTLGLQTY
                     LTAGPKESRAWTIKKGATAPEAAGVIHTDFQKGFIKAEVISFTDLVETGSVAEARAKGK
                     ARMEGKEYVMQDGDVVEFRFNV"
ORIGIN
        1 gcagttcggg gtgggtctgc tcgacgacgg ccttgtcctg cagcaccaga acgacggctc
       61 tgttgagcgt caccgtcgac agcggctcga agctcgcgtt cagtaccagc gtgtcccgca
      121 ctccagccca cctcctgtgc accagcccac cccccggcgg gcttggatca actctggccg
      181 ggcacgccga gatggacaac gcaataaaaa atgcccgcct ctgatcactt ccaagaccag
      241 agacgggcaa acgttcaatg aacgtccggc ttcgttactt ttccgctacc gccgcgtact
      301 ctccgatgag ttgagcacgc gcaagtgtgt ggaatcgcag attgaatccg accacggcgg
      361 gcgaagcatc cgaatccggg ccgagcttct cctgatccac ggagtagacc gtgaacacat
      421 accggtgcgc cggatccccg ggcggcggcg cggcaccacc gaagtccttc gtcccgtagt
      481 cgttgcgcac ctggaccacg ccctcgggca gcccctcgaa cttccccgag cccgcacccg
      541 ccggcagctc cgtcaccgag accggaatgt cgaacaggac ccagtgccag aatccgctcc
      601 cggtaggggc gtccgggtcg tagcacgtca cggcgaagct cttggtctcg gccgggaagc
      661 cctcccagcg cagctgcggc gaggtgttgc cgcccgcgta gacctgggcg tccttgagcg
      721 tcgcccccgg ctcgacgtcc tcgctcgtga ccgtgaacga cggcacgacc ggatggaaat
      781 catgggggag cggcggcctc ttcggctggg tcacctcgat acctcctgtg gatctggggg
      841 tgactgtgct cagagcctag aaccagctgc gcttgctacc gacttccgac agccactggt
      901 tcagatacgc cgcccaatcg gtgccctggt agtcctgcag ccccaccttg aacgcacgga
      961 acgagtcgct gccctcgctg aacagacccg gcttcttgtc catctccagt acgacgtcca
     1021 tctcgcgctc gtcggcgacg aaactcaact cgacctggtt cagcccgtgg tactgctgcg
     1081 gcgggaagaa ctcgatctcc tggtagaacg gcagcttctg ccgcgtaccg cggatgtgac
     1141 cgcgctccag gtccgcgttc ttgaaacgga agcccagctg gacaaaggcg tccaggatcg
     1201 cctgctgcgc cggcagcgga tgcacgttga tcgggtccag gtcaccggag tccaccgcac
     1261 gcgcgatctc cagctcggtc gtcacaccga tgttcatccc cggcagcgtc tgcccctgga
     1321 tcgtggtgac cggcgtctcc cacggaatct ccagcccgaa cggcaccacg tgcaccgcct
     1381 cggccttcag ctcgaaggcc ccaccgagcc gctgcttcgt gaactcgatg tcctgcttgt
     1441 actccgcgtc ctgaccctcg acctcgacct tggcctgcag accgacggac agcgcctcga
     1501 tctgctggtc cacggagccg ccctgaatcc gcacctcacc ctggacgacg ccacccggca
     1561 cgacattgac ctcggtcagc accgtctcga ccgaagcgcc accggccccc aggctcgcga
     1621 gcagccgctt gaaccccatg tctgttcctc ccgtcaggca acgcctgtgt atctgtgtgg
     1681 ctctgtgttc tgtgtggtgt ggatcgcgct gcgtggcgtg gatccttgat ccctacaaac
     1741 gcagaccgac ggcgaccggt tccgcgcccc acccttccaa ggaggacgcc ccctcgccac
     1801 ccgtcggccc gcacccgtct ggactacgct cgtacgccat gatcgcgatc cccgaccgta
     1861 cgcccctcgc ccgggagttc ttcgaccgcc ccgtcctgga ggtcgcaccc gacctcctgg
     1921 gtcgcgtcct cgtgcgggta accccggacg gtccgatcga actccgcctc acggaggtcg
     1981 aggcctacga cggggccaac gaccccggct cgcacgccta tcgcggtcgc accgcccgca
     2041 acggcgtgat gttcggtccg cccggccacg tgtacgtcta cttcacctac ggcatgtggc
     2101 actgcatgaa cctcgtgtgc ggtccggagg gccgcgcgag cgcggtcctg ctgcgcgccg
     2161 gcgagatcac cgagggcgcc gagctcgccc gcaaacgtcg actctcggcc cgaaacgaca
     2221 aggaactggc caaagggccc gcacgcctgg ccacggccct ggacgtcgat cgggccctcg
     2281 acggcacgga cgcctgcgcc ctcgacgacc cggccctgac agtcctgacc ggcacccccg
     2341 taagccctga ccaggtactg aacggtcccc gcaccggcgt cgccggagac ggcggtgtcc
     2401 atccctggcg cttctggatc gccaacgacc cgactgtcag cccctatcgg gcccacgtcc
     2461 cccgcgggcg ctcaacttga ctcgctcctg ggcggtccgt aatgtagccc gagccgcttg
     2521 aaccggttac ggcgatcagc cagcagccga gagcggccaa cccactacct acgacatccc
     2581 ctcagcgggg gcgaattagg catgccctaa ttcaagcccg cagcactcga ttatgagttg
     2641 ccgagggaat cggctaacgt agtgaatgtc gaaaggccgc aagggaaacc acgaggccta
     2701 aaggcaaatc ccgccgacag gggatcggat cggaaaacga tctgatagag tcggaaacgc
     2761 aagaccgaag ggaagcgccc ggaggaaagc ccgagagtag cttgggcgtg tcgagcagcg
     2821 caccgacttc gacaagctga tcgtcgacgt cgagaccaag caggcgatgc gtccgcgtga
     2881 cgccatggcc tccgccggta agacgctggt cgagctgttc ggtctcgccc gcgagctgaa
     2941 catcgacgcc gaaggcatcg acatgggtcc gtccccgacg gacgccgcgc tcgccgccga
     3001 tctggcgctg ccgatcgagg agctggagct caccgttcgg tcgtacaact gcctcaagcg
     3061 tgagggcatc cactccgtgg gtgagctcct ggcgcgctcc gaggccgacc ttatggacat
     3121 ccgtaacttc ggtgcgaagt ccatcgacga ggtcaaggcg aagctggccg gcatgggcct
     3181 gggcctcaag gacagcccgc ccggattcga cccgaccgcc gttgccgacg ccttcggcgc
     3241 gagcaacgac acggacgccg gttttgtgga gaccgaggag tactgagcgc tgcgctgcac
     3301 ctgggcaggg aaccgccacg ctgttccctg ccggggtcca agtaggaacg gaacacgaaa
     3361 ccggggagcg gacggagacg tggctcccgg tcgaacctgg ttccgctgaa ggcggccctc
     3421 ggcttcctgc tcagcgtgct ggcccgcgac cgaggggagc gggccagcag cccaaatccg
     3481 gcatttactt gtccgcaccg aggcacaggt acttgtccgc accgaggcac aggccgacct
     3541 ccacgaagtg cgccgtctcg gagtcgaggg ctacccgacg ctgccgctgc acaccgcagc
     3601 cggcacggac cgcctcggcc ggccccgtct cctcgtccga ggccctcacc gccgcactca
     3661 accagcacct ggccgccacg accggccgac ccgcgcgcgt ctgctacctg aggccgacgg
     3721 ccgtactgcc ggcgagggtc gccgcgggta cggacgcggg ggcgccgtcg acctcatgac
     3781 ggctcaacgc cgtcacggtg taggtgtgca ggcccaccac gagggccggg gcagcgccgg
     3841 ggcgagggac cgcgtaccgg ccagcacgtc cacggcacga gcgccggcca tggcggcggg
     3901 acctgcgggg gtggacttga gggccaggtc ataggcccac accagcccgg cgagcggcac
     3961 ctcggtggcc aggccgcgcc gcctcccggg gacagcggcg agtccgagtc cggccctcgt
     4021 gagcccactt gccacagcga gcgcgctccg acgactgata cgcccggagg ggccgggtcg
     4081 ttggggacgc tcgacggcgt cgaccacagc gtcggcgtag tcgttgaggg ccatcccgcc
     4141 ccagtacagg cagatggacg aggccgtcat ccccgagtcc ggaccgctgt cgggcggccg
     4201 cctgcggcag ctccggccag tacgtcacca ggaggtgcat ttcctggccc gggtatccgc
     4261 cccgcaccac cgccggctcg aacggcgggt cactgcacgg tgctgtcggc ctcacccgcc
     4321 accagccgtc gcactttccc ggtgaacaca ccggcctcgt taccccgggg aaacggttca
     4381 tcgggcacgt ccacgccgag gaacgcgcac agcggctccc agccctgacg gacctcgtag
     4441 accaacagct tctccggatc gaccgcagcg cgcaccgcct cgttgtgccg ctcgaagacc
     4501 gcgatcgtct cctgctcgcc gaggtcggtg cggaagccct tggcggccat ggcatccgtg
     4561 agcgacaaca acatgtcggc catcctccgc gcgtccggct cggccgcctg ttccaggtgc
     4621 cgccgcaggt cctggttcag gatggtcgcg cgggcgctgt cgtaccactc cttcggatcg
     4681 cggacgctca gcagcacctt ggcgtccggg tagagctcca tcatctcgcg ccagagcagg
     4741 gcgccgggga aatcctgggt ggcccggtac ttcccgacca ggccgggcag gaccgatgcg
     4801 tcaccggtca gtgccgcgat ccatccggca gaggtgtcgg ggttctggat cacctcggtc
     4861 atgtggtgac acgggccgta gccgagcatc tccaacgcct ctttcagcga ggccgtgccg
     4921 gtgcggccga atccggcccc gatgacgtca accatgctgc tgccgccctt ttcagtgatg
     4981 aagcggattg cggccgtcgc gtagcctccc ggatcaccag ccagtagtcg gcggcgaggc
     5041 ccggcagcgc cgggtcgacg ggcttgaccc agcttgatcc acgacggtgc acgccaagac
     5101 ttccacatca actgcgctta tgtgcgacgg gtttgatcgg cagcgaaccg tccgcgcgat
     5161 gtggtcgggc acgggggccc gcccggccgc agtgacaagg gcggatgcgg gcgacagacc
     5221 cacgctcgga ccatgcgccg accgggccgg ggtgcgtatc gtcatgctca ccgaggacca
     5281 tctcagcacg ccgccacgat cgcccgggag ctgcgccccg aggaggagcg cagctgatga
     5341 ccggggtgga gccggacaac ctggacgatg ccgcgctcgc ccggacgtgc gctcgccaat
     5401 atcccagcac agccccagca cgggaaatgg ccaggggccc gcccccgcaa ggtcggcccc
     5461 catctgacct gcccgtttgt cagatcagcg acgtggtggt gtgtcgcccg ctgcacgttg
     5521 gatccaagcc gtgctacgtc atgtgtgctg cggcttgcca tccgctcgca cgaggccggt
     5581 ggccttcagc gccttcttga agtggtacgc gtaggccgtg gccttgggca tggtgccctt
     5641 gctcctctcc cgggtgcgaa gaagacctcc ggttccgtat ctcggcccgt tctgtccttg
     5701 aacgccaccg gcacggcgtc ctaccgctct atgtgggcgt cgatctcgtt cttcgaggaa
     5761 cggctccgtg gggatgtcgc ggtacccccc ttccgcccgg tgctgtgtcc cggtcgctcc
     5821 ggggaagtgt tgacggcatg tgattccgac ccccgacagg gcttcaccag aactgccgga
     5881 ggttgaagct tttcaaggag atgttgctcg caggctcggt cgaactcctg gcatagagca
     5941 gcggcatcgc tttctggggc gagccataag cggcgctcca tgcgagccac tgatacgcgt
     6001 cccatccccg ctccataccg attcccacgc cgtctttcct caaggtggtc aaggccaggc
     6061 gatggtggaa ggcgacatgg taacgagccc ggacctccag ggggcgccgc tcgtaccggt
     6121 cgaaccagca cagcgccgat gcgccccgct cactgggacg ttcgccgttc ttgtgcagcc
     6181 tgagcagatg gtcgaggtcg tggcgctcgt tccgcatgaa ccgctgcatc gtccccatgg
     6241 ccgcctcgac cgccgagtgc agtgtctccc cgcttctcca gtgcggttcg gcgggcgcac
     6301 cggaccagtc cgggccgaag acctcgtcca tgtcacgctc gaccaggtcg ctgaagggat
     6361 cgagcggtgt gaaccggaat tccgtgtccg agacggcgtt gtggcacgcc agcgccgccc
     6421 gtaggtcgtc cgcgtgctga tcgaggatgc ggagcagatg ctccacccgt ccctcggtcg
     6481 cgtagtgcag gaagaccaac gagttcaccg tgctggcggc ccggtcggtc gccgtctgct
     6541 gggaaacgtt gaccgtccgc ttcctggcga gcgagttgtc catcagcgca ctgacgaacg
     6601 ccaccatgcg ggccgtgccc ggaccgctga cgtgctcggg aagcaccggg tcggtcacac
     6661 cggcccggtg tgcgcacagt ccgatctcca cgtcgagggc aggcctgtcc tcgagtagcg
     6721 ccgagaggaa acgcgcgcct tccagatagc ggttcgactc cgggttgaac atctcgctct
     6781 gtcggctgaa gcggaagccg gcgatcatcg tggggaccaa cgccagcatg cgcgacacgc
     6841 tgagggcact gcggtcggcc ctggacagcc ggtccagtag ctctctcgcc ttgatgatct
     6901 cctgacgtgc ggcgagctga ccgctgccgg cgtagatcat cgctgcgatc gccgcctccc
     6961 accggcgtgg ccgcttgagc gccagcggat ggattcccgc aatctcgtcc ggggaaggaa
     7021 gccgcgtgtc caccgactcg gcgtccttac ggatgccgca cagcaccgct atctctcgca
     7081 cgtcgatctt cgatccgttg tagcggctga gcgcctgcga cctcgagtag tcccaaaacg
     7141 ttatgtcctc ggccatcact tcgttcttcc tgcggttcgt ctcgttcgga tgcctgtcgg
     7201 ccgcggcaga ccccgccgcg ctggtcagcc gtcttcagtc gccgggtccg tccccgtcct
     7261 ggcggacctg gccgacggca cggcgaacgg cggccagtgc ggcggtggcc gccgccgcgc
     7321 tggtggccag cagggcccac ggccaccagg ggcccagcgt cagcgccccg gtcaggacca
     7381 gcggggcgat cgctgagccg accccccagg acagctggtg caggcccagg tgccggccgg
     7441 gtacgtcctc gggggccatg cgaacggcca cgacgtcgct ggtgggggcg tgcatcagtt
     7501 ccgccgcggt gaacaccagt accgcgaccg cgagcagcgg cagtaccgcc gtgcgcggca
     7561 gcccgctcgc cgtgccgaac agcacggccg ccgccgacca cagcatggcc gcccattgaa
     7621 ggacgcgcag gtactcgcgc cgctccaggc gccgcaccac cagggcctga cccgccgtca
     7681 ccagcgcggt gttcagcgcg aacaccgcgc cgacgaccca ggagggctgg tgcagccact
     7741 gcacgacata cagcggtacg agcacaggaa gcgccgctga gaccagtacg agcagcgtgt
     7801 tggccgccac catggtgacg tacgcgcggt cgggccgggg ccgggccggg cggggcctcg
     7861 gaaccgccgg agccgggccg ggggacgggg gccgggcggc ggtcggcagc agggcgatca
     7921 ggaccgtggc gagggcgtag ctgaccgcgt tgcccgccat gaccagccgc aggccggtcg
     7981 ggccgagccc ggccaggaag cccgccgcga gcccgccgac cgccatcccg acgttccgca
     8041 gggtgcgttc gaggccgtac cagcggagca gctcgtcggg tcggcagcgg cgagccagga
     8101 acgcccggtt ggccggccag aacaggttgt cccccagcgc cgcgagcgtg gccaggacca
     8161 gcaccgccgg ccacgagccg gtcgtcatgt agccgaggaa cgccgtcgcg cgcagcacat
     8221 gggccgtttg gacgagccga cgtgggctcc accggtccat gagcggcccg gacagcggcc
     8281 ccgcggccag ggctgcaacc ccagccactg tcagcagcgt gccggcggtc gccgccgtca
     8341 ttcggtcctg gccggtcagg tagaggagca ggaagggcac ggccaggccg ctgcccgtgc
     8401 tgtcgaccag cacggcggcg agcagcagcc gctgaccgcc cagccggggc agaccgagcg
     8461 ccgtgctcag tcgtcccggc cgcggcggcg ccgacggtgc cgcgctcatc gcggcgcgag
     8521 ctgccgtcgg cacagcgggc cggccgacgg cagctcgcgc cctcgcccgg gccgtaccgc
     8581 ctcgtcgacc cggccggtgt ggcgacggga acggaaggac cggtgcgtcc cgtgccaccc
     8641 gcgcaccgcg ccggcggcgg aatcgcgggg ggtgcgcaca cgtgcgtccg cgtcggggcg
     8701 gggatcagcg agcgggtggg ttctcacggt gtcttccgat ctctggggcc ggggcggagc
     8761 cgcgcgggcg ggacccgcgc ggccgacggt ggggcgtcac ttcacgccga ccaccatgtg
     8821 gtccggtccg tcgaggtgac gtacggtcac ctcgcggaat cccgcctccg tgagccagga
     8881 actggcttcg gccccggtgt aaccaagccc cccggcggag gccagggaga cgttgaggct
     8941 ggtcagcatg cccgtggtgt gcttcctgcg gtcgtcgtcg atcagcatct cgtagatgag
     9001 cagggagccc gacgggggaa gcgcctcgta cgccttgcgg atcagcatct tcttgatgtc
     9061 gaggttccag tcgtgcagga catggcccat cacgatgacg tcggcggagg gcagcggctc
     9121 gtggaagaag tcacccgcca cgaaccgcgc ccgaccgacg gcgggcgagt cacccaggta
     9181 ggccgcgaag ctgtcggcca cctgcggcag gtcgaagccg gtgccttcga ggtgctcgtg
     9241 cgcggtcagg atgtgcgcca ggaaggcgcc ctccgcgcag ccgacgtcca ccaccgagcg
     9301 cgccgcggac cagtcgaacc tcgtggtcag cgccaggtgc gcaccgaggc tgaacccggt
     9361 catggaccgg acgaaaccgg tgacctgctc cggggtggag tacgcctcgc cgaaggtgtc
     9421 ggccgtgggg tcgccctcca gcagaacccc gccgcgcacg gtctcacggc cgccgtcggc
     9481 cgccgcggcc agcgcctcgt tacggttcag ccggcctccg ctgcgcaccg cggcggacag
     9541 ctgggaccaa gccgggaaag cggagttgag gtactccagg taaccagtga tgtcggtggc
     9601 ggggcgctgg gggttcagat aggtgtcggc gagcggggtg ttctggtaga tgccctcggc
     9661 cgagcggtcc agcaggccga cggagaccag cgcgtcgaga aggtccggtg cgccgcggcc
     9721 cttcagggag aggtcggcac ggagttcgtc ggcggtgcgc ggcttctccg cgagcgcggc
     9781 gaagaccttg agttcgacgg cgctcaggag cgccttggag gtccagaagg cagtggcgag
     9841 ggagatgatg tcgtgcggcg agtgggggtg ggtgtgctcg ttcacggtgc gttcctctgt
     9901 ttgtgcccga cagccgggta cgcgtgggct cggccggtgg gtgccgtcgc gtcgtcggcg
     9961 ggcgccgggc aggggcggtg gtgtgctggg cgcgggcgtg tcacagcgcg gccatggcgt
    10021 tgcctaggta gttggggagc cgtaccagcc ggtcccagag ctcgttcagg tccacggggt
    10081 agctctcccg atagcggcgg gtcacggcct ccacctcgga ccaggtgctc ggcatcctgc
    10141 cgtcgttgta gcggggcgcc agctgctcgt agagcgtggt gccgggacgc aggaagagct
    10201 ggttcagccc gaagtaaccg ggcaggttcg tcgcccagtc cagcaactcg ccgttctggc
    10261 aggcggggtc gtcgggcagg ccgagcagga caaaggcgaa cggggtgata ccgacgtcct
    10321 gcaacgtgcg caccgccgcg tcggtcacac cgggcttgac ccgcttgccg accggtgtct
    10381 cggcgatccc gggggactcg gcaccgagcc acataccctt gcagccggcc tgcgcccact
    10441 gcgccacgtc cgtgcgcagc accacctcgg cccggctctg tccggtccag ccgaggccct
    10501 gtccggtcag gctccggcac aggtcctggt agaaggtggg gtggagaccg aagacgtagt
    10561 cgaggaagaa gacgaagtcg acgccgcctt cccgcatggc cgcgatctca gcgagggttc
    10621 gctcgacggg ctgcgggcgc atacgggtgc cgaaaggcag atggcagaag gtgcagccgt
    10681 acgtgcagcc acgcaccccc agaaccatgc cgcacgagcc gcggcgcacc cgcccgtcca
    10741 tgaacacctc ggctgtgtag gaggtcaggt cgaacaggtc gtaggcgggc agcggccact
    10801 gctcgggggc gagttgcgga taggtgtcca ccagcggcat caccggcagc gcggggcggc
    10861 cggcggtcag gtcgcgtacg gcctggatgg cggcggagtc cacctcgccg cgggcgacga
    10921 agtcggcgcc cagttcggcg cgggtggcct cgggcagatg ggtggcgtgc ggtccgcagg
    10981 caagcacggt cgcccccggc cactgccggc ggctgccctc caccagctcc ctgaccgggt
    11041 gcagtacgag gggatagcac tgggcgcggt cagcgatggc ggtgacgacg accacgatgt
    11101 cggggtccgg gccggtgtcg ggcggggtgt cggtgagacg gttgtcccac acggacacgc
    11161 cgatgccctc ggcgcgcagg gcagcgcagg cgttggccac gtcgaggggg agctgaagga
    11221 agtcacgctc gaattcgtcg tcggggatgg caaaacagac gtgggtcatg gggactcccg
    11281 ggcggaatca tgggcgcggg caggcagcgg cctgggacgg gggctcggga cggggcccgg
    11341 tcgccgccgg ctttgccgcg gtcgcgccag ggggtgcggg gggggaggaa ggggggagcg
    11401 ttggtgcgta ccggcgctcc ggtgtacgcg gacgggtgac cggaaggtgc gcggcgggga
    11461 agcaccggtc gggtcgcggt gctcgccctg gcaccgggac cagggggcga aacgcccgtc
    11521 ggccgacgtg ctcaccgccg tcggcggggg cgcactggcc gtgtcaagcg ccgcaccatc
    11581 atctcgaacc tcttctcgtc gtcgtggatc aggccgtcgg tcaggggtga ccggcacacg
    11641 ggggagggcc ggctggtgcc ccttcctgcg gggcgggagc tgtgcgagga cgggatgtgg
    11701 gagtcccggc cgcacccggg ccatctcccc accgcgagcc tacgaagatc atcctgggct
    11761 tccccagccc ctacggcccc tacgaacccc tatcgcgcac ctgggcgaga gccgacgcgg
    11821 ccgttccgcg gcgaaccgag ccgagggcac ggaggcgagt gcgagggtct tggagaagag
    11881 cccgcccgtg cacccccgtt gcccgtcggc ggggcgccgc ggagtgcggc gtgcgctccc
    11941 ccttggcgat cctccagcgc acgtcggcgt acccccacag cgcgcggccg gctggtaggg
    12001 ggtcgtaggg gccatagggg ctggggcagc ggctgacgat cttcataggc tcgcggatgc
    12061 gagatggctc ttgtgcggcc cggccggctt cggacgattc ttccggcctc cgtctgcgcc
    12121 cttgccgctg acgggtgtcg cggtgcccgc acaccccgtt ctcgcacagc tccccacgcc
    12181 gcgggagggg gcacaactgt ccttccccgg cgtatcgatg gcccgatacc acgacgagaa
    12241 gaggttgaga cgatggcttt tgccgagagc gagtccctgg gcgtcgcggt cgaggccggt
    12301 accgcgacgg atcgcggcgc cggccggtac gagatcctcg acggccgtat gacgcctcag
    12361 gacgtcgacg agacggtccg ctcggtacta cgcggagagg gggtgccact tcgggacctc
    12421 acggaaccgg agccgggtgg ccacctgatc gacctggacg gcaccctcgt acaactgcgc
    12481 agccggcaga tcgcggacgc ggccccggac accctggccc ccatcgatcc cccggccggc
    12541 cgtacccagg tgctgctcgc cgccgccgga ccgctgtccg gaagggccga ggccgtcttc
    12601 gaccgcctgg tcgaggcgtt gaccctgcgc ggccggtgct acacggctgc ggagatcgac
    12661 tccatcgtgg agggcatgcc gctggtcgcc cgctacgcca ccgaggagcc ggccttccgc
    12721 gactgggcac tgatcttccg cgaccactac gtggagaaca gcgtcggttt cctgctcggc
    12781 atggagcgcg ccggaatcga ccgggagtgg atcttcgcgc tgaacaaggg tgaccgcacc
    12841 ctgcaccgcg accgcgtcca cgcctggttt ctgcaccgtg gctaccagag cgacaccctg
    12901 gacaactcgg tgatcaacgg ctcggccgac accaccgcgc gcgcgtacgc cctggcagtc
    12961 aacgagcggg tggacgactt cgtccgccgt gcacacgagg cgggccgcaa ggtgttggtg
    13021 gtcgacgacg gcggcctgct cgcgcaaggg tacggagccg acggcatcct cgacgaacgc
    13081 atcgacggcg ccctggagtt gaccgtcagc gggctgaagc gcatcgccgg tgcccccggt
    13141 gaactgacca tcccggtgct gaacatggcg cggtcgaggc tgaagagcat gctcggctac
    13201 aacgagatag ccgactcctg cgtacgccgg ctgcgtgccg tcctgcccgg cgagaagttc
    13261 atcggccgcc atgtcctgct gctgggctac ggcacgctcg gcgcccgggt ggcgcacgcg
    13321 ctgcgcgcgc tgggctgcag ggtcgccgtc gtggacacgg acatcctggc cctgatcacg
    13381 gccgccgaac acgggtacga gacgtacatc agcgcgggcg aggcgctgaa cgcccacgcc
    13441 cccttcctga tcatcggcaa caccggcgaa ctcgccctca cccacgccga tctgccgctg
    13501 ctgcccgacg gggtccacct cgcgggcttc gccaccaagg acttcagcct gctcagcgag
    13561 gggttcgagg gactgcggtc cacggtgatc ccccaggtcg gcgtccgcta cgccctgccc
    13621 accggcacca cggccaccct gctgggcgac ggccgctcgc tcaacctctt cgagtacgag
    13681 gggatcgcca accacggcta cgacgcctac cgggccggca cgctgatcgc cgcgaagacg
    13741 ctgtgccgcg aggccgaccg gctcgggccc ggcctccatc tggaacccgt ggaccgggcg
    13801 atcgacgagg cgggactgtt ctccgcctac tacgaggagt acctggcctc cggcacccgc
    13861 cgccccgccg caccggccga cacggccatg cccgccgccc cggccccggt gacccgatga
    13921 ccccccgcgc gttcggcccc cacgtgtgtg tgatcggcta cggggccgcc ggccggctgc
    13981 accaacggct gctgagtgac ctcgggttcg acgtgagcgt ggtcgatccc gccccgggtg
    14041 tcccgcccac cgcgatcccg gtcttcgacg gggccgagca ggccgcccgc caccgccccg
    14101 tcgacgtctg gtcggtgtgc tcgccgaccg ccacccacgt ggcgaccgtg gcggacgtgc
    14161 tcgccgtcga ccccacggcc cggctgctcg tggagaagcc gctgtgccgc acctgggaga
    14221 tccccgagct gacctctttg ctggaccacc accccgatgc ccgtctggtg gtcatggacc
    14281 agtaccggca ctcccaggcg atggccctgc tgcgaacact gcggcaggag ctggcacccc
    14341 ggcacgagct gcgggcggtc cgcgtcgggt tcggcaagga ccggcgggcc gacatcgcgg
    14401 cgggccgctt cgtcgaccac gactacggcg tcttcggcta tgagtggctg cacatgctgg
    14461 ccctggtgcg cggcgtactg ccgtcgggga cgtacgaccg ctacatgtgc accggccccg
    14521 aggagtgggg cctgcgggtg gcgaccgacc ccgaactgac cagcaccgcg gcccacgagc
    14581 aggccgtggc cgagggcgtg gacatcgagc tgtactccac catcgtcggc tccgacccgt
    14641 ccgggcaggt cgccgttccc acctggttca gcctgcccgc cgcggccggg gagagcagac
    14701 aacgccatgt cgaagtactc accgggccgg tctgcttcga gctggacctg gacccggtga
    14761 cgctgtcccg gggcacccga ctcccgcgca acacccaccg gctcgtggtg caggggccgg
    14821 agctgcggcg cgagtggctc atccatgact cgcccctgga caacgccctg cgctggtcgg
    14881 tcgccgcgct gctgtccccg gccgggccgc ccggcctcga cctgcgcggg gtggcgcgca
    14941 tcggcctgct cgccgatacc gcccaccccg ctgcccgccc ctcctcggtc cgcaccgagc
    15001 tgcgcacgtg agcccgctgc gcctctgcct ggtggtgccc gccggcccgg tcgaccggtt
    15061 cgtcgtccgg gtcccgctgg acgtcctggc cgccgcggcc gggctccgtg ccgacggcca
    15121 cgaggtcacc gtatgggacc agcgccttcc ggataccccc ccggtcacgg aagaccccga
    15181 cctgctggtg gtcttcacag ccggcgtcgg ccgcgcccgg cgctaccccc tggacctggc
    15241 accggtccgg gccgccaccg accgtgcccg gcggcggttc ccgggcgccc gtaccatggc
    15301 ggtcggcccg cacggcaccc acctgccggg agccactctg ctcgacctgg cagtggacca
    15361 cgtcgcggtc ggcgaggccg gctcggcgac cgtgcacggc gtacgcgacc tcggggcggg
    15421 gaccgccgca cccgtcctct acggcgacct gccacggccc gccgcacccg tgaccgtggt
    15481 gggcaaccat ccccggccct acccggacct cgaccaggac cggtggccga tgcccgcata
    15541 cgacctggtg cccctggagc ggtacacagc ggaggtggtc gtggacggcg taccgcggcc
    15601 ggggccggca ggcacgatgc tggccacgca tgacggcacg ttcgaccatc ccccgttcgg
    15661 tgccgggccg cggacccggt cggtcgaccg ggtcgtcgcc gaggtagcgg cacagcgggc
    15721 tgccggtctg ccgtcccagt ccttcctgga ctcggttttc ggcatcgaca cgtcgtacta
    15781 cggagtgatc tgcgagcggc tgcgcggtca gggcatcgac tgggtggccc ggacgagcac
    15841 cgagaccgtg ctgaagaccg aggtcacccg gtgggccgag gcgggctgcc ggggcatgtg
    15901 gctgcgggcc gagccgccct cgggggtcga cgccgggcag ccgttccggg acgccgtgct
    15961 gaagctgcgc gacgcgggta tcaccccgtt cgcctccgtg ctgatcgggc tgccgcgcga
    16021 cgcagcccgc gtgccggacc ggctggtcga ctgggcggcg gaactccccg cccggttcgg
    16081 gctcgacctg gtttccccgc gccccggtac accgctgtac gacaggctcg ccccgggcct
    16141 caacggcggt acggcgcccg cgacctggca ggaggtcagg gacgtgaccc ggcggtaccg
    16201 ggcggactac ccggccgacc tcgatgacct ggagcgtcgg ctcaccgcgc tccccaacca
    16261 cctggccgac gccacggccc tgactggatg agatgtttct gtgctgacgt tcggagtgat
    16321 cggctgcggg tcgatcggcg gcttcctggc ccggctgctg acccgcgagg acaaggaact
    16381 ggccgacagg gcgcggctgg ccgcggtcgc cggccgggac ccggcgcggg tcggcgcgtt
    16441 ggcggccgag gtgcgctgcg gggcgaccga cgtggcgggg ctgctggccc ggcgggacgt
    16501 gaacgccgta ctggtgtgca ccccgagcgg cacccatgcg cggctggccg aggaggcact
    16561 gcgcgccggc aagcacgtgc tggtggagaa gcccgtcgac gtgacgccgc agaccgcaga
    16621 ccggctgatc tccgtggccc gggaggcggg acggacgctc ggtgtggtgt ctcagcaccg
    16681 cttcgacccg gccgcccggc tggcccgtac ggcgatcgca tccgggcggc tcggccgggt
    16741 caccagcgtc atgaccgagc tggcatggtg gcgcggttcc gcgtactact cctccggcac
    16801 ctggcgcggc acgccggccc tggacggcgg cggagcgctg atgaaccagg cgatccacgc
    16861 cgtggacctg gtgcagtggc tggccgggcc ggtggtggag gtggccgcgc acaccgcgcg
    16921 actggcccac cccggtatcg aggtggagga cgtggcgacg gccagtctgc gcttcgcgaa
    16981 cggcgccctg ggcaccctgc tcgccaccac ggccgcctac ccggggcgca ccgcccggac
    17041 ggccgtgaac ggggaccggg ggtccgtggt catcgacgac gacgaactcg cctatctgca
    17101 ccttgcccgg cacggcgagg acgcgcccgc gtacggagcg ttcggtaccg ccgaccagtc
    17161 cgccgactac gcggcggcgc tggtgcggga ccctgcccgg gacgcctcgg gtctgctgta
    17221 ccagccgcac cgggaccagc tcctggactt ctgcgacgcg gtgcgggagg gacggccccc
    17281 gctggtggac ggggcggcag gacggcaggc ggtggccgtg gtgacggcga tctacgcatc
    17341 cgccaggacc ggccgaccac agcgggtgga caccggaact cctgcgggga tccgcggtac
    17401 ccctcgcttc accaaggaat caccgaaggg cgaccagcag acgaccaaac agtgatcacg
    17461 ggaaggtaaa tccgggaaac ggcagggttc gcctcgcacg gtcgcccctg cctcgccgat
    17521 ggcgcacgca aggcggcatt cccgcaggaa gcagacatgg aatacacgca gaatctccac
    17581 acgggagacc ctcatgcgac gccctcgcgc tcacaccgtt gaacaccatc acgtgcggca
    17641 cttcaccagc cactcccttt gcttctctat gcccacgtaa agcacatgga aagattctga
    17701 atggcgatcc gataccccac ctgaccagtc ctacacttga tcaacggcgg acgggggttg
    17761 ctcgccgccc gggaggaagg acccggggcg gctccatgca cctgaacagg acggttatga
    17821 tgcgaacgga aatccgcgat ttatttctga cgccgttcgg tgaccccatc aatctgatca
    17881 accagcgtgg cagaatcttc atcctgcaag gaggtccagg aactggaaaa actttctatc
    17941 tggaagaggc gaaaaggctg gccattgcct cggattcctt atgcctgcac gccaccgggt
    18001 ttcgcgaaga gcatgaaatc cccttttctg ccttcgagca gttcattcac gttccgggga
    18061 ttcccgacac cgtacggtcg gccgtgtggc ggctcgtgcg acgtacggcg tccgccaccc
    18121 cgtccggcct cgcccccgca cgcctcctgc aggacctctt ctccgcgctg gtcgcggcgg
    18181 cgaaacacac cgggatggtc atcctcatcg acgacgccca gtacctggac gcggactcgc
    18241 actcctgttt gctctatctc gcccgccgcg cccagtccca caacatcacc atggtggtgg
    18301 cctacccgcc cgatgccttc tgcgacgcca tcggtaaccg gctggacctc ctcggactcc
    18361 ccggcgcctg tctgctcaag gccaccagcc tgagggaaaa cgatgtcagg acgctgctgg
    18421 agcgtgggct cggtgccgag ggggccacac ggctggctgc gccggtgcac cggatcagcg
    18481 gcggcaaccc cgccctggcc gcagcgctgg tccgcgacct gcgcgtggcc ggaggcatcg
    18541 agcccgaaac gccggtcccg atcggggacg cctttcggac cgcctacctc gccggtctgg
    18601 cccgccaccc gtgtctcgcg aagaccgtcc aggccctcgc cgtgctgggt gacgacgcga
    18661 ccccggcacg ggccgcccag ttgctggaga gctgccccca tgagatagcg aagcacatcg
    18721 cggcactcga atgcgcgggc ttactcggtg agggcggctt ccggcatccg gccgtgccgg
    18781 gcgccgtcct cggcatgctc ggcgccgaac tggcgagcct gcaccggcgg gcctccgcgc
    18841 tgctcgtcgc ggagggggca ccggccctcg ccgtcgccca gcacctgctg gccgcgcagg
    18901 agcggcccga cgtatcccat gtgccggtgc tgcgacgtgc ctggcagcag cttctcgtgg
    18961 ccgggcagac ggaccgggcg ctcgcctgtc tacgcctggc cgaccaggcc gaactcgggg
    19021 aagagcagcg cgccgaaatc accgccgagt tggtccacac actggtctgg gtcaatcccc
    19081 tggcggcgga gcccgaggtg ggccggctgc tggccgcggc gcgcgccggg cgagccgact
    19141 gccgtgcgct gcgcctcctc gtcgcctggc tcctctggtt cggccggcac gatcgggcac
    19201 gggaggtgct ggttcagctg gtcgagacct gcgacccgtc ccacgcggac gacgggaaac
    19261 gggccctgtc caccctgatc ggctgcctgt ggccggaagt gctcggcgac cccgcggtac
    19321 gtggctactt ccgcaccgcc caggacagca cccttgccac cgggtacggt gcgacggcga
    19381 tacctccgtc tcgcaccgcg gtggtccact ccggccgcct gcggcgcctt ctgtcgccca
    19441 tggccgccac ggagtggaac gacgaccacg aggccgccgg gcggcgggcc gcctcggcag
    19501 acatggacgc tcggccgttc tggaaactgg atctcgcggc cgtaatggaa ctggtgcaag
    19561 agggtgagac aaccctcgcc gaccggctct gcgaggagaa gcgaacccgc ctgcccgcgg
    19621 acgagttccc cgtccggcac gcgttgctgg ccgctctgca cggccacatc cgagggaaac
    19681 tgggagaccc gcgtacggcc tcggagtgtg cccaggcggc cttggcactg ctgcacgagc
    19741 agggctgggg cgtcgctgtc ggcctacccc tgtcggtcct gatctccgcc cacaccctca
    19801 tgggcgatcc gagccgggcg gcccactacc tggaacgacc cgtcccggac gagatgtggg
    19861 actcgtcgtt cggcccgctg taccgcatcg ccctcggctg ctacctcctg gagacaggcc
    19921 gtccggacat ggcgttgaac gagttcatcg cctgcgcccc gaagggcgaa gaccgaccgg
    19981 ccgacccctt cggctgctcc tgctggcgcg cccacgccgc agaggcgtac ctggccctcg
    20041 gcgagccgga gcaggcccga cggatggccg acgccgagct cctgcagggc gaccggccga
    20101 ccgacgcccg aggtcgagcc ctgcggatcc tggccgtggt cgacgccccc gagcagcgca
    20161 gggctcatct ggaggaggcg gagcgcaccc tgcgcggggc gcacagccgt ctcccgctcg
    20221 cccaggtgct ggcccagctc agccaggtgg acctggcgga cggtcacacc cgtaccgcgc
    20281 gggcccgctg gaaagaggcg ctgagcctgg ccgccgcatg cggcgtgccc catcggttac
    20341 ggcctcccgc gagcccactc gacgagccgt tggccccacc ccagccggcc tgggcggagg
    20401 gcggacagcc gacggcaacc ggtccggcgc cgaggcacac cactggcgcc gggggtctga
    20461 cggaggccga gtggcgggtt gcctcgctgg ccgcagcgcg caggtcgaac cggcagatcg
    20521 ccgcccagct gtacatcaca gtgagcacgg tggagcaaca tctgacccgt gtgtaccgaa
    20581 aactctcggt ccgccgccgg tcggacttgc ccggcctgct gggactccag tcgcaagagg
    20641 gagatcagac cggtttcgtt ttctagtcga ccaagcccga gcaccacggt gcaccccgtg
    20701 gatcggctcg actgcggatg tcccagcccg ccggccgggc gggtgccgtg tccccgccgc
    20761 gctcaccgag gtagcgggcg cccacgccat ggccgatgcc ggtgccgagt cccttgagat
    20821 acgcctcttt acgggcccac agccgggcga aggcgaccgg gcgcagactc tccggggcgc
    20881 ccgcgatctc cgcctgttcc gccggatgga gcgcgggggc gcacagcgtg acggtctcgg
    20941 gaccgggcac tccctggacg tcgacgccca cgggtgccga cgcgatcccg gccaggatca
    21001 gcccgtggct gtgggagagg gagaagtgca gggaaagccg agcagtacgg ggcggccgtg
    21061 cgggccgccg caccgcgggc agcgtgcgcg tccgaggcgg agccggtccg gggggactcc
    21121 ggtgtaggcg gccagcagcc gtctgagggc gatgtgcgcc gacagataca gcagccggtg
    21181 ccgggggcgt gccgtcgcgg cggcccgccg ggcctcccgt gcgctgagtt cgtcggtcgc
    21241 gctgcggggc agcggcccgg cgccgtgggc cgcgcgcagc agccacacgt gcagcgcgcc
    21301 ctcctcgagg ccggagccga ggcggtcccc gccgtcggct ccggcctgtg tgtgccgcgg
    21361 tctgtgcggc cgtggtctgt ccggctggcc ggggccgccg gggcggtccg ggacggtcgg
    21421 cccgtcgttg ctgtgcgccc atggccgggg ccaccttcct gcgcctgtgc gggcccccac
    21481 atgacgggcc ccggggcgag gacgacctgc cccggggcct cgaatcacgc ggagagcccg
    21541 ctgcctttct gcggctgccg gctacctggc ctgatcaccc gtcgcggtta ccttctgctc
    21601 cggctgcggg gcctcgccct cctcctcgag ggtgggcgtg acccggcgga gcagggtggc
    21661 caccagcagg gcgatggcga gggcgatgac cacgctggcc gtgtaggaga tctggatgcc
    21721 gtcggtgaac gcggtgcgca cggcgtccag gagggactcc ttggtgtccc cgctgaggtc
    21781 ctccgccgcc gcgacggcgg agccgatgct gtcctcggcc gcggccgtgg ccgcttcggg
    21841 ggtgccgtcc ggaatgctgt cctgcacctg ggcgcggtag accgcggtgc cgaccgcgcc
    21901 cagcagggcg atgcccaggg cggcgcccag ctcggcggcg gtctcctgga tggccgaggc
    21961 ctcgccggcc ttctccgcgg gagcggtggc gagcaccatg cccgtgccca gcgccggagt
    22021 cgggcccagg cccaggctca tgatggcgcc gccggcgatg accatgccga tgccggaatc
    22081 ctcggtcagc cggctgagga tgaacaggcc cacggcggcg atcgccagtc cgccggccat
    22141 caggtaggcg ggccggatct tctgggcgag tccgggggac gccatgatgc cgatgaccat
    22201 catcacggag atcggcagca tcagcagtcc ggcctccatc ggcgtgtacc cggacaccat
    22261 ctgcaggaac tgggccagga agaactgcgc gccggccatg acgaacatcg acagggacag
    22321 cacggccagg gcggccgcga aggtacggct gctgaacagg cgcaggtcca ggagcggcga
    22381 ctcgaggttg cgctggcgca gtacgaaggc tgcgcagatg gccaggccca cggcgaggat
    22441 cagcgaggag gtggcctcaa tgccgtgcga ggcgtactcc ttgatgccgt agaccaccgg
    22501 aagcacgccg accagcagca tcagcacgct gaggaagtcc agccggcccg gctgctcgga
    22561 gcggtactcc ggcagcagga tgggcccggt gatcaccagc agggccatca ccggcgcgcc
    22621 cagcaggaag actgatcccc accagaagta ctccagcatc acgccgccga cggccggtcc
    22681 cagggcgccg cccagcacaa agcccgccat ccacacgctg atcgcgacgt tgcgctgctt
    22741 cgcgtcgtgg aacatgttcc gcagcagcga catcgtggac ggcatcaggg tcgccccggc
    22801 cacgcccagc agcccgcgcg cggtgatgag catcaccgga ctcgtggaat aggccgcgag
    22861 aaccgaggct gcgccgaatc ccaccgcgcc gatgagcaac agccgccgtc ggccgatacg
    22921 gtcacccaat gtgcccatgg tgatgagcag accagcgatg aggaaaccgt agatgtcgac
    22981 aatccagagc aattgcgtgc tcgacgggtc gaggtctgca ctcaaatgcg gcaccgccaa
    23041 gtgcagaaca gacatatcga gggcgatcag gatggtcggc agagccagga cggccagccc
    23101 taaccactct cgcttcccag ccttgacctg gggagatgtt gtcatttccg tctccatggc
    23161 gccaccttag aacctcaact gaacttgagg tcaagcaggg tcttcgcgcc acctttcgga
    23221 atgtggcgca attacttccc gattccttgt tcgggaaatc cggaatgccg tgcgatcagg
    23281 cctcgtaagg acgtttgtcc cgcgcctccc tgagggccag ggaccaccac tcgagttggc
    23341 ctagcatgct tttcaccgtc ggcgcgtaag cctcttcgtc ccgaatgcgg ccggtggcgt
    23401 ccagcagtgc ggtggccttg tggaagctga ttgagtcccg gacggtcatc gcgtgcagtt
    23461 cggcgaagac ctggcgaagc tgttcgaccg cgcgcagccc cccgctcatc ccgccgtagc
    23521 tcacgaagcc gaccggtttg gcctgccact cggtgcgatg ccagtcgatg aggttcttca
    23581 acgccgccgg aaaactgtgg ttgtactcgc ccgtcaccac cacgaacgcg tccgccgacg
    23641 ccagcacggg tgtcaccttc cgcggctcgg cgctgatctc cgcgctgcgc cggtccaccg
    23701 cgagaggcag cgcgatgtac ttggcgtcga ccacgtcgac ctcgaaccgc ccgtgggcac
    23761 gcgccgcccg gaggaaccat ccggcgaaca ccggcgccag ccggacgtcc cggacggtgc
    23821 cgacgagcac ggccaggcgc aacttctcct cagacatgga cacttccttc cggtggtacg
    23881 gacgactcgg cggacgttca gggggagcgg cgcagagcac cggcgagcgc gacgagggct
    23941 cccgcgccgg cgaccgcggt gacgaggagg agcgcgtcct ggtacgcgag gccgtccccg
    24001 gtggccgggc cggcgccgtc gccccggccc agcagcagcg ccacgaccac cagcacgacg
    24061 acggcgccga acgggacggc ggcctggtag acggcggtgc cgaccccctt gtccgcgggt
    24121 cgcagcccgg acgacgcccg catgttcagc gccccgaagg ccagcatgaa gccgacgccg
    24181 aacagcagca gggtcggcag ggcgtcggcg gcgtacgagc ccggctcctc caggcgggcg
    24241 tagagcgcgc agccggcggc gggtgccacc gcgcccagcg cgatgagcga gggggctccg
    24301 aagcgggcgg ccgtactcgg cagtgaacgg gacgatcagc cgcaggtgga tgtcgactgt
    24361 gtgaggcgac ctggggcggc ggcggagggc tccgttgcgg aggatgtcga agtaggcggt
    24421 cacctcgccg cgtatctgct cgggaagcac tgcgaggtga gctctgacca gttgttcgag
    24481 ggtgtcgggt gcgtcgtcga gcaggatgtc gagatcgttg agcatgtcga tgagatggac
    24541 tgcggggaca tcgatgtccc gggacagtgc gtgcaccgtg caccgtggtg gctttgatcc
    24601 tttcggaagg ctggtgcagg gccgagagga tcatcaagcc tcacttcacg cgcttgatgg
    24661 tgcagcgatt ccagcccccg taccgccgcg acgtccctgg cccgatcgac gaggaagtcc
    24721 gcatagccgg gatctgcggg ggtgaatcct gtccaggagc gcctcttcga gccgttcggg
    24781 ttccgatagc tgccggaagt cccggaccgg ctcgaaaagc gtgagttgga tactctcggg
    24841 cggcttcagc agcagggggt gcctgtgcgg cgtttcgctc ggcgaatcag gcatctccgc
    24901 tgttcttgcg gtgaggtggt ggcgccgatt ccatttgatc aggtcagcga gaaacgtctg
    24961 gtgcccggtt gcggctgcga ccgtgaggtc caaccgggcc ccgtggccgg ctgacgggac
    25021 cttgatacgg ccgacgacga atgcggcctg gtgacggcag gcccggcaga ctccgtcacg
    25081 cagggggacg gtcgcgccgt acgtgccgca cgagtcggca gggtacttgt accaccatgc
    25141 cctgcacaca tagcagagga tcgtcgagcc gcccgggtta gggtgaaggc cccaggccat
    25201 gcagacctcg caactctcag gcgtcccaag ccccttggcc ttcgcttcct tcgtcacaac
    25261 ggcggcaaag aaagtgtgag cgcggatttt gtccggtccc ggtcaaacgt cacctgggac
    25321 tagacattac tcggccacgc ctgtttcacc tcccacaggg ctgcggcgcc cgagtcagca
    25381 cgggaccctc accgatatcc cagcacgatc ccagcacggc agggatgagc aggggtgatg
    25441 acaggtgacg aggggtcagg tttcccagca gcatcccagc accatcccag cacgggaaaa
    25501 aactaggggc ccgaccccgg agagtcgaac cccttctgac ctgcaagttt gcgagatcag
    25561 cgatgtggtg gtacgtcacc cgctacacat tgaaccggaa ctcgacgacg tcgccgtcct
    25621 gcatcacata ctccttgccc tccatgcgcg ccttcccctt cgcgcgggcc tccgcgaccg
    25681 agccggtctc caccaggtcg gtgaaggaga tgacctcggc cttgatgaag cccttttgga
    25741 agtcggtgtg gatgacgccg gcggcctcgg gggcggtggc gcccttcttg atggtccagg
    25801 cgcgggattc cttggggccg gcggtgaggt aggtctgcag gccgagggtg ttgaagccga
    25861 cgcgggcgag ggtggcgagg ccgggctctt ccgcgccgac cgactcgagc agctccatcg
    25921 cgtccgcctc gtcgagctcg gcgaggtccg cctccagctt ggcgttgagg aagatcgcct
    25981 cggcgggggc gaccagggcg cgctgctcgt tcttgaagtc gtcgtcgatc agctcgtcct
    26041 cgtccacgtt gaagacgtag aggaagggct tcgtggtcag cagatgcagg tcgtgcagga
    26101 gctccgcgcg ctcgccgccc tggacgatgc cctgcgagaa gagggtgtcg ccccgctcaa
    26161 ggatctcctt ggcctcctcc accgccttca ccttcggcgc gacgtccttc ttgatccgcg
    26221 actccttcgc caggcgcgga aggaccttct cgatggtctg gaggtcggcg aggatcagct
    26281 cggtgttgat ggtctcgatg tcgtccttgg gcgagacctt gccgtcgacg tggacgacgt
    26341 tctcgtcctt gaaggcgcgg atgacctggc agatcgcgtc cgattcgcgg atgttcgcga
    26401 ggaacttgtt gccgaggccc tcaccctcgc tggcgccgcg gacgatgccc gcgatgtcga
    26461 cgaagtcgac ggtcgccggg aggatccgct gggagccgaa gatctcggcc agcttggtca
    26521 ggcgcgcgtc cgggacgccc acgacgccca cgttcggctc gatcgtggcg aacgggtagt
    26581 tggccgcgag cacgtcgttc ttggtcaggg cgttgaacag ggtcgacttg ccgacgttgg
    26641 gcagaccgac gattccgatc gtgagcgaca cgtttgcgac ttcccgtacg taggaggagg
    26701 gccaggcggc cggggcctgg ggtggcaggg cccggggtca gggcctgtcc gccggatcct
    26761 gcggatcgtg ccccagcggc cagagggctg gccgatcccc cagtttacgg cgtgccgacg
    26821 cccaccccgg cgacgtatcg aacgcttggc caaggtctgg ccaacggcgt gtctgtagac
    26881 ccattcggca cattaaccga cctaagttgg tgcggtggag caacccagga cgcacccccc
    26941 tcggaccggc cggccccgcc gcacggccct tccgcccgtt ccgccgcagg cggccagagg
    27001 cgggcggggc ccgacgggcg cgggggcacc gcgtcgtgcc ccggtcgcgc gcgggcccgt
    27061 tccgcccccg gtccaagccg tacggcgcgt cgtccgcgcc gtgcgccgga tgccgaaccc
    27121 ccggctcacc gggctgggct gcgggttgtt ctgcggagcg tcgatgttcg cgctcgcctg
    27181 cctcgaccgg ctgctgttcg ggggctcccc caccctgtac ggggtgctgt tcctgctggt
    27241 cagcgcgttg accgcggtgt gggtgcggtc gggcgacctg acgagtgcgc cggtggtcgt
    27301 acccatcgcc ttcgccgccg gactgctccc gatcgccggc ggcgagggcg gcctcggcgg
    27361 gcatctgatg ggcctgatca ccgccctcgc cgtggaggcg ggctggctgt acggcggcac
    27421 gctcgtcgcc gggctcatcg tgaccgtacg caagg
//
