LOCUS       NZ_CP022161            10216 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces capitiformicae strain 1H-SSA4 chromosome.
ACCESSION   NZ_CP022161
VERSION     NZ_CP022161.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces capitiformicae
  ORGANISM  Streptomyces capitiformicae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Streptomyces capitiformicae sp. nov., a novel actinomycete producing
            naphthoquinone compounds isolated from the head of Camponotus
            japonicus Mayr
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10989391)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUN-2017) Life of Science, Northeast Agricultural
            University, No. 59 Mucai Street, Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Feb-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002214185.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:26:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,013
            CDSs (total)                      :: 9,935
            Genes (coding)                    :: 9,274
            CDSs (with protein)               :: 9,274
            Genes (RNA)                       :: 78
            rRNAs                             :: 2 (5S)
            complete rRNAs                    :: 2 (5S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 661
            CDSs (without protein)            :: 661
            Pseudo Genes (ambiguous residues) :: 0 of 661
            Pseudo Genes (frameshifted)       :: 220 of 661
            Pseudo Genes (incomplete)         :: 571 of 661
            Pseudo Genes (internal stop)      :: 32 of 661
            Pseudo Genes (multiple problems)  :: 155 of 661
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:06:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 152270
            Orig. end                         :: 162486
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022161.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            67..2208
                     /locus_tag="CES90_RS00580"
     CDS             67..2208
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="CES90_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_189782050.1"
                     /transl_table=11
                     /translation="MSDVYASRGRTTVETARLGHPMLSLALAAMMDDVDAHSGAVYLLT
                     ADEPVLEMAVMAGLPRSFAAPWERVGLSTPVPVAEAVRDRRLVWVNGEEQMARRYPRIA
                     VVLPYPFALAALPVATRDTTYGAVFLTWPGSHPPELSDRERDHLTSACDRLAKRLRRAE
                     EEGRPVLPEPDLSAPSATTVAGTLGTVEAARMVARLPYGMCALDLHGRISFANAATAEL
                     LGIPVSGLLGTQLWASVPWLNDPSYEDRYRAALMSQHVTSFVALKPPNDWLSFRLYPGT
                     NGLSVRISRARAVAEMEGAARRDDDEPGRLVTINHVLALASALTEAVGVQDMVELVANE
                     IVPAIGAQALLMLGSRAGRLHVLGHRGYADPRLVEGFDGMPLTAQTPGAHVLSSGVPAF
                     FESRQQLEHLYPMQRTTRDGLGAWAYLPLIAQGRPVGTCVLGYAEPHPFPADERAVLTS
                     LSGLISQALERALLYDAKHQLAHGLQAALLPHSLPSIPGIESASRYLPATRGMDIGGDF
                     FDLVLSHGRASAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQAPQDVMSSTNRLLIDL
                     GSELFASCLYLRLDPEHGMAVMARAGHPPPLLRRPDGKVKVLDLAGGPLLGIDADAVYP
                     TTEVALGEGSLLALYTDGLIESPGVDIEDALADLGERLASVGEQALDAVADELVRETET
                     AQERLDDVALLLLRAAKVG"
     gene            complement(2433..3824)
                     /locus_tag="CES90_RS00585"
     CDS             complement(2433..3824)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484004.1"
                     /locus_tag="CES90_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S1 family peptidase"
                     /protein_id="WP_189782049.1"
                     /transl_table=11
                     /translation="MAALGAAALILPNAMASQTESNQAAPKTLAASDASDLASQLREAL
                     GEAFAGAYYNSSEQQLIIQVIDGIEIDGDDNNVIIQAQEAGAKVQEVENSWSELKAGAA
                     TLKEKASIPGTAWAIDPRTNKLQVTADSTVTGENWDTIESTVKSLGSGMAEIKKSAGTF
                     KTFLEGGDAIFGGGARCSAGFNVVNAQGAPAFLTAGHCGVAEAEWSEEEGGAPIGTVDA
                     ATATFPGDGDFALVNYNDPATQAASTVDLGNGETVDINAAGEATVGLQVFRMGSTTGLA
                     DGQVTGLDATVNYPEGTVTGLIQTNVCAEPGDSGGSLFTQDGQAIGLTSGGSGDCTVGG
                     ETFFQPVTTALAAVGATLGDGGAGAGEEAAGGAGDEAAAAGAGGEAGAGEEAAAAGAGE
                     EAAAAGAGDEAGAAGAGGEAAAAGAGGEAGAGEEAAAAGAGEEAAAAGAGEEAGAEHEQ
                     GVVEH"
     misc_feature    3982..3993
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.57"
                     /tool="antismash"
     gene            4084..4497
                     /locus_tag="CES90_RS00590"
     CDS             4084..4497
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676669.1"
                     /locus_tag="CES90_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PaaI family thioesterase"
                     /protein_id="WP_189782048.1"
                     /transl_table=11
                     /translation="MTLTPAEADKILATNFAPWVLDLGLTAVELDERRAVLRLPWCDRL
                     AREGGALSGQALMAAADTATVIAVSAARGSFVPMTTVQQSTSFQRAVTGEDVLVEAVLT
                     KLGRRMAFADIAMTTGSSGELAARASTVYALLG"
     gene            5001..5216
                     /locus_tag="CES90_RS00595"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="CES90_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type A2 lantipeptide"
                     /protein_id="WP_189782047.1"
                     /sec_met_domain="strepbact (E-value: 2.1e-32, bitscore:
                     110.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETAELSDAALDAVSGGLQVNALGTVTGLVDGVAPVSGL
                     VNTAVTTVEGATGLSTAPVTSLVAGL"
     gene            5339..6145
                     /locus_tag="CES90_RS00600"
     CDS             5339..6145
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="CES90_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_189782046.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLVLSITVVAMAAASVW
                     AVTGSVTSTVSAPAILTHGQGSYILQSPVAGQVTAVLAKQGERLPAKAPVLKVATAEGE
                     TVVRSVAAGRVSALAATIGQIIQTGADVAAIEKVADADDPLYATVYVPAENAASIPKNA
                     EVDLTVQSAPTQSYGVLRGHVKKVDRTAQTPQSIGAFLGDSQLGEQFTRKGRPVAVTVR
                     LDRKASTESGYKWSSQDGPPFELSSMTMATGSIRMADERPIDWLLP"
     gene            6142..8379
                     /locus_tag="CES90_RS00605"
     CDS             6142..8379
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115096.1"
                     /locus_tag="CES90_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_373313300.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.4e-37, bitscore:
                     127.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPQDTAPPSGHGRRKAAAKKRPVPRSRQRTVRTPTVLQMEAVE
                     CGAASLAMVLGHYGRHIPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDVAAL
                     AEVKGPAILFWEFNHYVVYDGMGRRFGRRGVHINDPGKGRRFVPMEDFDASFTGVVLVM
                     EPGADFERGGRKPGVLGAMPARMRGTSGTLPAAVLASLLLVAVGAAVPALSRTYIDMFL
                     IGGQTSLLGVLFASMGACVLLTVLLTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTF
                     FSQRSPADLVQRLQSNDVVAETLARDLAAAGVDAVVVVLYAVLLYTYDPQLTFVGIAVA
                     LLNVVAMRVVIRLRATRTAKLRADSARLTNTAYTGLQLIETMKATGGEEGYFRKWAGQH
                     ATTLEEQQRLGVPSAWLGVVAPTLATLNSALILWIGGMRAVEGHISVGLLVAFQSLVTR
                     FTAPITRLNGVAGRIQDFAADVARLKDVENFQADPLYTRPDAGESTRRLHGHVELENIT
                     FGYSPLDKPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYTPWEGVIRIDGRRL
                     EDIPRGALATSVSFVDQEVFLFEGTVRDNVALWDPSIPDEAVVEALRDAALYDVVTRRP
                     GGINSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRKR
                     GCACVVIAHRLSTVRDSDEIVVLQHGTIVERGRHEELVARGGAYAQLVRER"
ORIGIN
        1 ccgggccgtc aggggggagc cttgacccgg gggccgtcgt gccgccgtgg gaggaggtgg
       61 tcgggcatgt ccgacgtgta cgcgtcccgg gggcggacca ccgtcgagac ggcacgcctg
      121 ggccatccga tgctgtcgct ggccctggcc gcgatgatgg acgacgtcga cgcgcactcc
      181 ggcgccgtgt atctgctgac agccgacgag ccggtgctgg agatggcggt catggcgggg
      241 ctgccgagat cgttcgccgc gccgtgggag cgggtgggac tgagcactcc ggtcccggtc
      301 gccgaggccg tacgggaccg gcggctcgta tgggtgaacg gcgaggagca gatggcccgc
      361 cgctaccccc gtatcgccgt ggtcctgccc taccccttcg ccctggccgc cctgccggtg
      421 gcgacccgcg acaccaccta cggcgccgtc ttcctcacct ggcccggctc gcacccgccg
      481 gagctcagcg accgtgagcg ggaccatctc acctcggcct gcgaccggct cgcgaaacgg
      541 ctgcggcgcg cggaggagga gggccggccg gtactgccgg aaccggacct gtcggcgccg
      601 tcggcgacca ccgtcgccgg gacgctcggc acggtggagg cggcgcggat ggtggcgcgg
      661 ctgccgtacg ggatgtgcgc gctcgatctg cacgggcgga tctccttcgc caacgcggcg
      721 accgccgaac tgctcggcat ccccgtcagc gggctgctcg gcacccagct gtgggcgtcc
      781 gtgccctggc tgaacgatcc ctcgtacgag gaccggtacc gggccgcgct gatgagtcag
      841 cacgtcacgt cgttcgtggc gctcaagccg ccgaacgact ggctgtcgtt ccggctgtac
      901 ccgggcacga acgggctgag cgttcgcatc tcccgggccc gggcggtcgc cgagatggag
      961 ggcgccgcgc gtcgggatga cgacgagccg ggccgcctgg tgaccatcaa ccatgtcctg
     1021 gcgctggcca gcgcgctcac cgaggcggtg ggggtgcagg acatggtgga gctggtcgcc
     1081 aacgagatcg tcccggccat cggcgcgcag gcactgctga tgctcggttc gcgggcgggg
     1141 cggctgcatg tgctggggca ccgcggttac gcggatccgc gcctcgtgga aggcttcgac
     1201 ggtatgccgc tcaccgcgca gacccccggc gcgcatgtcc tgagcagcgg ggtgcccgcc
     1261 ttcttcgaga gccgacagca gttggagcac ctgtatccga tgcagcggac gacccgggac
     1321 ggcctgggcg cctgggcgta tctgccgctc atcgcccagg ggcggccggt cggcacctgt
     1381 gtgctcgggt acgcggaacc gcatccgttc ccggcggacg agcgtgcggt gctgaccagc
     1441 ctcagcgggc tcatctccca ggccctggag cgcgccctgc tgtacgacgc caagcaccag
     1501 ctcgcccacg ggctgcaggc cgcgctgctt ccgcactcgc tgccgtcgat ccccggcatc
     1561 gagtcggcct cccgctatct gccggcgacc cggggcatgg acatcggcgg cgacttcttc
     1621 gacctcgtgc tctcgcacgg gcgggcctcg gccgtgatcg gcgacgtaca ggggcacaac
     1681 gtgacggcgg cggggctgat ggggcagatc cgtacggccg tacgcgcgta cacgaccgtc
     1741 ggtcaggcgc cgcaggacgt gatgagcagt accaaccggc tgctgatcga cctcggctcc
     1801 gagttgttcg ccagctgtct gtacctgcgg ctcgacccgg agcacgggat ggccgtcatg
     1861 gcgcgggccg ggcatccacc gccgttgctg cgcagaccgg acgggaaggt gaaggtgctg
     1921 gacctcgcgg gtgggccgct tctggggatc gacgcggacg cggtgtatcc gacgaccgag
     1981 gtggcgctgg gcgagggttc cctgctggcc ctctacacgg atgggttgat cgagtcgccc
     2041 ggggtggaca tcgaggatgc gctggccgac ctcggggagc ggctcgcctc cgtcggggag
     2101 caggcgttgg atgcggtcgc cgatgagttg gtccgggaga cggagaccgc gcaggagcgg
     2161 ctggacgacg tggccctgct tctgttgcgg gcggcgaagg tcgggtgact cctgccgggg
     2221 cgccgacgcc ccctgggggg tgtggtgaaa gccccgcaca gcacccctga aacgcaccgg
     2281 tccgaccctc ccgccggagg gccggaccga gttccactca ccggccggaa ccgctgtggt
     2341 gtggtcggtg ggtgggtcgt gggatcgacg gtgcggtatc agtggccgct gagcccggaa
     2401 ccgtcgtcca ccacgtcttc gcgggtgtcg gcctagtgct cgacgacgcc ctgctcgtgc
     2461 tccgcgccgg cctcttcacc ggcaccggca gcggcggctt cctcaccggc accggcggcg
     2521 gcggcttcct cacccgcgcc ggcctcgcca ccggcaccgg ccgcggcggc ctcgccaccc
     2581 gcacccgcgg cgccggcctc gtcaccagca cccgcagcgg cggcttcctc accggcaccg
     2641 gcggcggcgg cttcctcacc cgcgccggcc tcgccaccgg caccagcggc ggcggcctcg
     2701 tcaccggcac cgcccgcggc ttcctcaccg gcgcccgcgc cgccgtcgcc gagggtggcg
     2761 ccgaccgcgg ccagggcggt ggtgaccggc tggaagaagg tctcgccgcc gacggtgcag
     2821 tcgccactgc cgccggaggt caggccgatg gcctggccgt cctgggtgaa cagcgagccg
     2881 ccgctgtcgc cgggctcggc gcagacgttg gtctggatga ggccggtgac cgtgccctcc
     2941 gggtagttca ccgtcgcgtc gaggccggtg acctggccgt cggcgagacc ggtggtgctg
     3001 cccatgcgga acacctggag accgaccgtg gcctcgccgg ccgcgttgat gtcgaccgtc
     3061 tcgccgttgc cgaggtcgac ggtgctcgcc gcctgggtcg ccgggtcgtt gtagttgacc
     3121 agcgcgaagt caccgtcgcc ggggaacgtg gcggtcgccg cgtcgaccgt gccgatcggg
     3181 gcgccaccct cctcctcgga ccactcggcc tccgcgacac cgcagtgacc ggcggtcagg
     3241 aacgcgggcg ccccttgggc gttgacgacg ttgaagcctg cggagcagcg cgcgccgccg
     3301 ccgaagatgg cgtcgccgcc ctccaggaag gtcttgaagg tgccggcgga cttcttgatc
     3361 tccgccatgc ccgagccgag cgacttgacc gtcgactcga tggtgtccca gttctcaccg
     3421 gtgaccgtgg agtcggcggt gacctggagc ttgttcgtac gggggtcgat cgcccaggcg
     3481 gtgccgggga tgctcgcctt ctccttcagc gtcgccgcgc cggccttgag ctcggaccag
     3541 ctgttctcga cctcctggac cttcgcaccg gcctcctggg cctggatgat cacattgttg
     3601 tcgtcgccgt cgatctcgat gccgtcgatg acctgaatga tgagctgctg ctcactcgag
     3661 ttgtaatacg cgcctgcgaa cgcttcaccg agcgcttccc ggagttggga ggcgaggtcc
     3721 gaggcgtcac tcgcggcgag cgtcttcggg gccgcctggt tggactccgt ctgggacgcc
     3781 atggcgttcg gcaggatgag ggccgccgct ccgagtgccg ccacgccgcc tgccgctata
     3841 aaggccttac gcttggtggc tcgtttgtga ctcaactctt gacctcctgg gggcggggtc
     3901 cgtgccgccg tcggcgggtg aactgggggc gcctggttgc cagttggtac ggatgcttcc
     3961 gatggggtgt tcaacgcctc ggaaaaagtt tccgatcttc cgcttcgcaa agtgcggttc
     4021 gggtggcatt tcacgacttc ccacccgcgt tccccggccc gaatccctgg gaacgatgcc
     4081 ggcatgactc tcacacccgc cgaagccgac aagatcctcg ccaccaactt cgccccttgg
     4141 gtactcgacc tcggcctcac cgccgtggag ttggacgagc gacgcgcggt cctgcgcctg
     4201 ccgtggtgcg accggctcgc acgcgagggc ggcgccctgt cggggcaggc gttgatggcc
     4261 gcggcggaca cggcgacggt gatcgcggtg tcggcggcgc gcggttcctt cgtaccgatg
     4321 accacggttc agcagtcgac cagcttccag cgagcggtca cgggtgagga cgtactcgtc
     4381 gaggcggtcc tcaccaagct cgggcgccgg atggctttcg ccgacatcgc gatgacgacc
     4441 gggagttcgg gggagctcgc ggcccgggcg agcacggttt acgcgcttct ggggtgacga
     4501 cagggcgctc ctgtgacaac tgagcgcaat acgtcaagcg agcagacacg atccgctacc
     4561 gatcggtagc cgtccgttcc cgttcccgat cgaaaaaccg gctccggcga atctccacat
     4621 cgaataccca gtcaggtcac ggcgcaccaa ggatctgcac ggccggcgcc accgcgccgc
     4681 gcctttgagg cgggactgtc cagttcgttt tccggttggc aacgagcggg ctgcgacgat
     4741 gcggcgcccg gtgtgaagaa cttggcaccg ccgcgtgcgc aggcctgcac ggatgagccc
     4801 tcatggtcat caagttccct ggtgagaggc tctgttgatt ggatgtgcgc cccggatctc
     4861 tgctttgatc catcgcaccg cgggggccgc caagctctcg gagacgagaa gtgggcaccc
     4921 acgtgtgcgg ccgtcgttct gtccccagaa gggggccgct cccccccctt atgaagagct
     4981 atacgaaggg aagttccatc atgaactcca ccccccaggt tgagaccgcc gagctgtcgg
     5041 acgccgccct cgacgccgtc tccggcggcc tgcaggtcaa cgctctcggc accgtcaccg
     5101 gcctggtgga cggcgtcgcc ccggtctccg gcctggtcaa cacggccgtc accacggtcg
     5161 agggtgccac cggcctgagc accgccccgg tcacgagcct ggtcgccggt ctctgatcga
     5221 gccccagtgc cgctgagtcc cggaaccgcc tgacggttcc ggggctctcg gatgcccgga
     5281 caccatcggg cgccccgaaa gtcctttcgt ctcacatcgc gcaggtgagg gaagtcccgt
     5341 gcagttccgc caacaggccc tcgccaagct ccagtcaccg gaggagctcg accttccggt
     5401 gcgcttcgcc cgcccccagg gctggctggt gctgtccatc acggtggtcg ccatggccgc
     5461 cgcgtccgtg tgggccgtca ccggttcggt gacctccacg gtcagcgcgc ccgccatcct
     5521 cacccacggg cagggcagtt acatcctgca gagccccgtc gccggccagg tcaccgccgt
     5581 actcgcgaag cagggcgagc ggctgcccgc caaggcaccg gtcctgaagg tcgccaccgc
     5641 cgagggcgag acggtcgtac gttccgtcgc cgcgggccgg gtctccgcgc tcgccgccac
     5701 gatcggccag atcatccaga ccggcgccga tgtcgccgcg atcgagaagg tcgccgacgc
     5761 cgacgacccg ctgtacgcca cggtgtacgt cccggccgag aacgccgcct ccatcccgaa
     5821 gaacgccgaa gtcgacctca ccgtccagtc ggcgcccacc cagagctacg gtgtgctgcg
     5881 cggtcatgtg aagaaggtgg accgcaccgc ccagacaccg cagtcgatcg gcgcgttcct
     5941 cggtgacagc cagctcggcg agcagttcac caggaagggc cggccggtgg ccgtcaccgt
     6001 acgcctggac cgcaaggcgt cgaccgagtc cggctacaag tggtcctcgc aggacgggcc
     6061 gcccttcgag ctgtcctcca tgaccatggc cacgggttcg atccgcatgg ccgacgagcg
     6121 tccgatcgat tggctgctcc cgtgacccca ccgcaggaca ccgcgccgcc gtcggggcac
     6181 ggcaggcgca aggcggcggc gaagaagcgc ccggtgccca ggagcaggca gcggaccgtc
     6241 cgtacgccca ccgtcctcca gatggaggcc gtggagtgcg gtgccgcctc cctcgccatg
     6301 gttctcggcc actacgggcg gcacatcccg ctggaggagc tgcgcatcgc ctgcggtgtc
     6361 tcccgggacg gctcgcgcgc gagcaacctc ctgaaggcgg cccgcggtta cggcctgacc
     6421 gccaagggca tgcagatgga cgtggccgcc ctcgcggagg tgaagggtcc ggccatcctg
     6481 ttctgggagt tcaaccacta cgtcgtctac gacgggatgg ggcgccgctt cggccggcgc
     6541 ggcgtgcaca tcaacgaccc cggcaagggc cgccggttcg tgccgatgga ggacttcgac
     6601 gcgagcttca ccggtgtcgt cctcgtcatg gagcccggcg ccgacttcga gaggggcggc
     6661 cgcaagcccg gcgtcctcgg cgccatgccg gcccggatgc gcggcacctc cggcaccctg
     6721 cccgccgccg tcctcgcgag cctgctcctt gtggcggtcg gcgcggcggt acccgcgctg
     6781 agccgcacgt acatcgacat gttcctgatc ggcggccaga cctcgctgct gggcgtgctg
     6841 ttcgcgtcga tgggcgcgtg cgtgctgctg acggtcctgc tgacctggct gcaacaggcc
     6901 aacctgctgc gcggccgtct gatctcctcc accctctcca gcgcccgctt cctcaggcat
     6961 ctcctccgcc tgcccgtcac cttcttctcc cagcgcagcc ccgccgacct cgtccagcgg
     7021 ctccagtcca acgacgtggt cgccgagacc ctggcccgcg acctcgcggc ggccggtgtg
     7081 gacgcggtcg tcgtcgtcct ctacgccgta ctcctctata cgtacgatcc gcagctcacc
     7141 ttcgtcggca tcgcggtggc gctgctgaac gtggtggcga tgcgggtggt gatccggctg
     7201 cgcgcgaccc gtacggcgaa actgcgcgcc gacagcgcac ggctcaccaa cacggcgtac
     7261 accggcctgc agttgatcga gacgatgaag gcgaccggcg gcgaggaggg ctacttccgc
     7321 aagtgggcgg gccagcacgc caccacgctg gaggagcagc agcgcctcgg cgtgccgagc
     7381 gcgtggctgg gcgtggtcgc gccgacgctc gccacgctca acagcgcgct catcctctgg
     7441 atcggaggca tgcgcgcggt cgagggccac atatccgtcg gcctcctggt cgccttccag
     7501 tcgctggtca cccgcttcac cgcgccgatc acccgcctca acggcgtcgc gggccgcatc
     7561 caggacttcg cggcggacgt cgcccggctg aaggacgtcg agaacttcca ggcggacccg
     7621 ctgtacaccc gcccggacgc cggcgagtcc acccgccgac tgcacggcca cgtcgagctg
     7681 gagaacatca ccttcggcta cagccccctc gacaaacccc tgctcacggg cttcgacctc
     7741 accgtcggcc caggtcagca ggtggctctg gtcggcggct cgggcagcgg caagtcgacg
     7801 gtgtcgaggc tgatctcggg cctgtacacc ccctgggagg gcgtgatccg catcgacggc
     7861 cgacgacttg aggacatccc gcgcggcgcg ctcgccacct ccgtctcctt cgtcgaccag
     7921 gaggtcttcc tcttcgaggg cacggtccgc gacaacgtgg ccctgtggga cccgtcgatc
     7981 ccggacgagg ccgtggtcga ggcgctgcgg gacgccgccc tgtacgacgt cgtcacccgt
     8041 cgcccgggcg gtatcaacag cagggtcgag caggacggcc gcaacttctc cggcgggcag
     8101 cgccaacgtc tggagatcgc ccgggctttg gtgcgcaggc ccagcatcct cgtcctggac
     8161 gaggtgacga gcgcgctcga cgccgagacc gagctggtcg tcatggacaa cctgcgcaag
     8221 cgcggctgcg cctgtgtggt gatcgcccac cggctcagca cggtccgcga cagcgacgag
     8281 atcgtcgtcc tgcagcacgg cacgatcgtg gaacgcggcc ggcacgagga gctggtggca
     8341 cgcggcggcg cgtacgccca actggtcagg gagcggtgag atgacctccg tacacgacag
     8401 ccacgggggc caggatgtcc agggaagcca ggtgaaccac gggggcgacc tcgtcctcgg
     8461 cgcgctcggc gccatgggca cacccctcga ctgcaccggc tacacccgcc tcgacctcga
     8521 aggcccgcag gtgctgtggc tggtggtctc cggcgccctg gacctgttcg cggtcgacgc
     8581 cgagcagcag ggccactggc accacctcgg ccgcctggaa gcgggctcgc tgttgctcgg
     8641 cccggtcgcc gggccgcaac acaccctggt cgcacgcccg ttgcgggact gcgtggtgcg
     8701 ccgcatcggg ctgcgcgagc tgtaccagcc ggtgaacacc gagacctggt cgtacgacga
     8761 atggggcaac ccccagctcg tacccccgca gacgagcccg ctggagtacg ccctcgccct
     8821 gggcgtcggc cgtggtctgt ccatcctctt ccaggcgccg atggccaccg agcaggcggc
     8881 cgcgctcacc gacgacgacg tgttctggat gcaggtgccg cccggcagcg tccagtacgg
     8941 ctcgctgtac ggcgcggagg cggcggccga cctgctgatg gaccccgggg tctggcagag
     9001 catggtcgac cagcagtacc ggctgctggc cacgctggac cgctggatcg agcagctgga
     9061 acgcacccac gaggaccgta cggcggcggg tatcaaggcc ggcgaggcgg tccgcgccca
     9121 ggccgaccga accctgctcg cgtccatcgg caagtcgtcc gcgacccggc gtacgacggc
     9181 ggccgacgcc gacgccacgt acgcggcctg caaggtcgtc gcccaggcgg ccgggatcgc
     9241 tctctccgaa cccgcgcaga gcggcacgga gagcgaccgg ctcgacccgg tggaacgcat
     9301 cgcgctcgcc tcccgggtcc gggtccgcgc cgtacggctc accggaagct ggtggcggga
     9361 gaacgtgggc ccgctggtcg ggcaccgggc cctgtccggc gcgccggtgg cgctgctgtg
     9421 gcggcgcggc ggatatgtgg ccgtgcagcc gtcgtccggc cgggagacgc cgatcgagaa
     9481 ggcgaacgtg gcggagttcg agccgcgtgc cgtgatgttc taccgcccgc tgcccgagcg
     9541 ggtgctgagc cccctgcgtc tgatgcggtt cagcctccac ggcaccggcg gcgacatgac
     9601 cggcctgctg ctgagcggcc tggtgacggt cgcgctcggg tcgctcgtac cgatcgcgac
     9661 gggcaaggtg ctcggcgagt acgtgccgaa ggcgcaggag aacctcatcg tgcaggcctg
     9721 cttggcggtg atgctcgcga gcgtggtgtc ggcggcgttc ctgctgttgc agaacctgac
     9781 gatcctgcgc ctggagggca ggatcgaggc gacgctccaa ccggcggtct gggaccgcct
     9841 gttgagactt ccgaccaagt tcttcacgac ccgctcgacc ggtgaactcg ccagtgccgc
     9901 catgggcatc agcgcgatcc gtcggacgct cgcgggggtc ggcccggtgg tcgcccagtc
     9961 ggtgacgatc ggtgccgtga acctggctct gctgctctgg tacagcgtgc cgatggcgct
    10021 ggccgcgatc gggatgctcg tggtcgtcgc ggcggtcttc ctcggcctcg gcctgtggca
    10081 ggtgcgctgg cagcgccgcc tggtggtgct gagcaacaag ctgaacaacc aggccttcca
    10141 gaccctgcgc gggctgccga agctgcgggt ggcggcggcc gagaactacg cgtacgcggc
    10201 ctgggcgggc gagttc
//
