LOCUS       NZ_CP021920            21935 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Bacillus sonorensis strain SRCM101395 chromosome, complete genome.
ACCESSION   NZ_CP021920
VERSION     NZ_CP021920.1
KEYWORDS    RefSeq.
SOURCE      Bacillus sonorensis
  ORGANISM  Bacillus sonorensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4832293)
  AUTHORS   Cho,S.H.
  TITLE     Genome sequence of Bacillus sonorensis strain SRCM101395
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4832293)
  AUTHORS   Cho,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2017) Bioinformatics Research Institute, Microbial
            Institiue for Fermentation Industry, 61-27 Minsokmaeul-gil,
            Sunchan-eup, Sunchang-gun 56048, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 181.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002202015.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 02:45:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,075
            CDSs (total)                      :: 4,961
            Genes (coding)                    :: 4,743
            CDSs (with protein)               :: 4,743
            Genes (RNA)                       :: 114
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 218
            CDSs (without protein)            :: 218
            Pseudo Genes (ambiguous residues) :: 0 of 218
            Pseudo Genes (frameshifted)       :: 158 of 218
            Pseudo Genes (incomplete)         :: 77 of 218
            Pseudo Genes (internal stop)      :: 30 of 218
            Pseudo Genes (multiple problems)  :: 43 of 218
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:23:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3579390
            Orig. end                         :: 3601325
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021920.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Microbial Institute for
            Fermentation Industry.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21935
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="11"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..21935
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21935
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11935](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11935
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(485..499)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     misc_feature    complement(589..606)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(677..898)
                     /locus_tag="S101395_RS18815"
                     /old_locus_tag="S101395_03782"
     CDS             complement(677..898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180197.1"
                     /locus_tag="S101395_RS18815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03782"
                     /product="hypothetical protein"
                     /protein_id="WP_006636658.1"
                     /transl_table=11
                     /translation="MCPVCNGILVEERACPRCGGEMADAGRTTDFYGPYSPYMEYDSFL
                     QTRSSCIHLYTCQDCSYDETVEIELTEA"
     gene            1132..1332
                     /locus_tag="S101395_RS18820"
                     /old_locus_tag="S101395_03783"
     CDS             1132..1332
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180196.1"
                     /locus_tag="S101395_RS18820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03783"
                     /product="alpha/beta-type small acid-soluble spore protein"
                     /protein_id="WP_006636657.1"
                     /transl_table=11
                     /translation="MANQNSSNQLLVPGAAQAIEQMKFEIASEFGVNLGAETTSRANGS
                     VGGEITKRLVSQAQASMGGQQ"
     gene            1452..1595
                     /locus_tag="S101395_RS25740"
                     /old_locus_tag="S101395_03784"
     CDS             1452..1595
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180193.1"
                     /locus_tag="S101395_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03784"
                     /product="hypothetical protein"
                     /protein_id="WP_167373800.1"
                     /transl_table=11
                     /translation="MQLVTSINWELLQFVGISLLHEYLINIRPFQAVFRFSGAFSPGRS
                     DV"
     gene            1620..2240
                     /locus_tag="S101395_RS18825"
                     /old_locus_tag="S101395_03785"
     CDS             1620..2240
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017360329.1"
                     /locus_tag="S101395_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03785"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_006636656.1"
                     /transl_table=11
                     /translation="MKIALFGGTGRVGRAFLHFIEAGGRHSVSALVRAEHPNLPSTCCR
                     TFRGNARNPEDAQALIKEADIVVSCLNTDGDDTLSVSIQNIINAMSAQNKKRLITIGTA
                     GILQSRQNPALYRFESNESKRRSSRAAKEHANVYERLLASDLNWTVICPTYLPDGPAVT
                     NYRVERNFLPIGGKEISTGDTAHFLYKQLNSDEFIRARAGLAY"
     gene            complement(2270..4291)
                     /locus_tag="S101395_RS18830"
                     /old_locus_tag="S101395_03786"
     CDS             complement(2270..4291)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180189.1"
                     /locus_tag="S101395_RS18830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03786"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_006636655.1"
                     /transl_table=11
                     /translation="MKTGKRLFQYALCYKNILICALLMLTAAVTAELTGPMIGKKMIDD
                     HILGIQKPWYEVSGKSEYTVPYHGREYVRADRADPSLEKRKEVRVFQIGMTYYFVDEAV
                     PFDGKRTVKDGVLRISSGGQSESYPAVRLSASEAFSFYEPEMKGLVSLILLYLGLLILS
                     IFFHYGQFYLLQMSANRIIQKMRQDVFANIQRLPVRYFDNLPAGKVVARVTNDTEAIRD
                     LYVTVLSTFVTDMIYMAGIFAALFLLDARLAAVCLLILPLIAIWAAVYRKFASGYNHKL
                     RSINSDINAKMNEAVQGMPIIQVFRRQKDIKREFEELNDSHFHYQNKMLNLNSLMSHNL
                     VNVLQNVMFAVLIWYFGGAALKMEGMMSIGVLYAFVDYLTRLFQPITGIVNQFPKLELA
                     RVSSERVFRLLDEPGVDVEETSGVKVNGHVVFEDVSFRYGDSGEYVLKNISFEAKQGET
                     VALVGHTGSGKSSIMNVLFRFYDIQKGDVKIDGTSIYDMSRQDVRQHMGIVLQDPYLFS
                     GTIASNVNLDHEAVTREQIEAALKQVGADKLLAHLPKGFDEPVIEKGSTLSSGERQLIS
                     FARALAYDPAILVLDEATANIDTETEAVIQKALDVVKKGRTTFIIAHRLSTIRKADQIL
                     VLDKGRIIEKGSHEELMKQKGQYYQMYELQKGRGTLVG"
     gene            complement(4288..6042)
                     /locus_tag="S101395_RS18835"
                     /old_locus_tag="S101395_03787"
     CDS             complement(4288..6042)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388852.1"
                     /locus_tag="S101395_RS18835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03787"
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /protein_id="WP_006636654.1"
                     /transl_table=11
                     /translation="MFSVLWKLGWFFKASWRRYTIAIVLLLMVNILEMFPPKLLGNAID
                     DMQTGAFSAMAMAGYIGLLIGLSLVVYTLSYNWMYQLFGGANLIEKILRSKLMGHLLKM
                     TPAFYEKNRTGDLMARATNDLKAISMTAGFGILTLVDSTMFMLTILFTMGFLISWKLTL
                     ASIIPLPLMAAAIGVYGKKIHQRFTEAQNAFGELNDQVLESVSGVRVIRAYVQEKNDVS
                     RFNSMTADVYQKNMKVALIDSLFEPTVKLLVGMSYLIGLGYGAYLVFRSQLTLGELVSF
                     NVYLGMLIWPMFAIGELINIMQRGNASLDRVNETLRHQPDVKEAPHPKRAEPGDIVFDK
                     VSFTYPSSSSENLSGISFAVLKGQTVGIVGKTGSGKTTLIKQLLRQYPEGNGTLAISGV
                     PIGDLPLDLLHSWIGYVPQDHVLFSKTVKENILFGGLHATEQDVADVIRAAHLEKDIEL
                     LSDGLETMVGEKGVALSGGQKQRISIARALIADPDILILDDSLSAVDAKTEAAIIENIR
                     HHREGKTTFITSHRMSAVEHADFILVMENGKISERGTHQELIAGKGWYFEQYEAQQLPS
                     GDEGGTVA"
     gene            6588..7088
                     /locus_tag="S101395_RS18845"
                     /old_locus_tag="S101395_03788"
     CDS             6588..7088
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017695384.1"
                     /locus_tag="S101395_RS18845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03788"
                     /product="universal stress protein"
                     /protein_id="WP_006636653.1"
                     /transl_table=11
                     /translation="MFTANRIIVAFDGKDDSKKALKKAIDLTKRIGAELTIAHVHEPRQ
                     AKPLANEQRPAAGTAYIYGGIPSVPPVPRESDIAGEPVIYEDSTEEAIAAAKIILNEHQ
                     FDANIEILEGDPANAVLRHAEHFGADLVITGSRDQNRLKKLLFGSVSDKISAKSEIPVL
                     IVK"
     misc_feature    complement(7577..7594)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: strong, score: 20.69"
                     /tool="antismash"
     misc_feature    complement(7667..7680)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.86"
                     /tool="antismash"
     gene            7841..8110
                     /locus_tag="S101395_RS26420"
                     /old_locus_tag="S101395_03789"
     CDS             7841..8110
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S101395_RS26420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S101395_03789"
                     /product="hypothetical protein"
                     /protein_id="WP_244185739.1"
                     /transl_table=11
                     /translation="MCELCKLLELRELCELLELCELLELRELCKLLELRELLELCRSLL
                     LELRKLLAWRRYVALRSRLPLPLLPQGPINHNGQQNYIYWYVLF"
     aSDomain        8133..8432
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_S101395_RS18855_Heterocycloanthracin_
                     C_RRE.1"
                     /evalue="2.80E-59"
                     /identifier="RREFam011.1"
                     /label="S101395_RS18855"
                     /locus_tag="S101395_RS18855"
                     /protein_end="100"
                     /protein_start="0"
                     /score="188.1"
                     /tool="antismash"
                     /translation="MTNLTASARLKVKQDTCFLPDPAGGVYVRNNSGSFRMKGASIYQW
                     IEKLLPMFNGEHTLEELTNGLPAPYRDRVFDIGGMLYKNGFVRDVSRDRPHQLEE"
     gene            8133..10001
                     /locus_tag="S101395_RS18855"
                     /old_locus_tag="S101395_03790"
     CDS             8133..10001
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003329452.1"
                     /locus_tag="S101395_RS18855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03790"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_006636651.1"
                     /sec_met_domain="TIGR03693 (E-value: 2.5e-256, bitscore:
                     850.1, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     4.9e-57, bitscore: 188.1, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 9.6e-13,
                     bitscore: 46.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNLTASARLKVKQDTCFLPDPAGGVYVRNNSGSFRMKGASIYQW
                     IEKLLPMFNGEHTLEELTNGLPAPYRDRVFDIGGMLYKNGFVRDVSRDRPHQLEENVLK
                     KYASQIEFIESFADSGAYRFQLCRQANILAAGSGSFLISLVRSLAESGFAKIHVFFTEA
                     RSDHQTALEELEAYARQADGDMIELTAVQDWREAVKSCDWILYASEIDDPEKLLALQSV
                     CREEKKRLFPAVCLKQIGLAGPFVHQDGDGCFESAWRRIHRSALQEERKVDTFPAAGKD
                     MLANVIVFELFKTVSGLASLTKRNECYLVDLSTLEGVWCPFLPHPLVSSDGGMAELVRD
                     IEAKVQNRSKPKEKGRLFQLFSQLTSEKAGIFRLWEEKHLKQLPLSQCFVQVANPLSEG
                     PAELLEKTVCSGFTHEEARREAGLKGIEMYGAKLADVSVIEDGFLGIGTGETIAESVLR
                     GLQKSLDAELQKRAKSGGETASPLSIGMINDKRAAFYLNALSIMHGTPEIGLGKDISGF
                     PVVWTGVCGRWYGSAGINITLALRNALQQALMNTRPLEEAAVILTENKIRLDIPVCEDH
                     TQLLDTALKSIRRNGLQLLVYDVPAEPFFEKALAGIYAVRLKKEEA"
     aSDomain        8154..8399
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_S101395_RS18855_Thiopeptide_F_RRE.1"
                     /evalue="5.40E-15"
                     /identifier="RREFam004.1"
                     /label="S101395_RS18855"
                     /locus_tag="S101395_RS18855"
                     /protein_end="89"
                     /protein_start="7"
                     /score="46.1"
                     /tool="antismash"
                     /translation="ARLKVKQDTCFLPDPAGGVYVRNNSGSFRMKGASIYQWIEKLLPM
                     FNGEHTLEELTNGLPAPYRDRVFDIGGMLYKNGFVRD"
     gene            10001..11935
                     /locus_tag="S101395_RS18860"
                     /old_locus_tag="S101395_03791"
     CDS             10001..11935
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180177.1"
                     /locus_tag="S101395_RS18860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03791"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_006636650.1"
                     /sec_met_domain="TIGR03882 (E-value: 1.4e-46, bitscore:
                     156.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.4e-133, bitscore:
                     441.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 8.3e-86, bitscore: 286.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERCILLVGEGMIADDVSKQLSGRYRVLRQPDVKAGIPGETGLVL
                     IVHDAWRPSVYHEAEAILRPAGIPWLRGFVSFGEGVIGPLVCPEDAGCSSCADMRRFIT
                     GPDSTEMRMLMQQNRDFHRDPWASQAGCRHMVRLICTEIKNMMENGRSRLKNKLWLINF
                     KTLDCSLHSVMPEPLCEVCGRLPDDTAESALISLKPAPKTGPGSYRTRRTDDLQDVLRQ
                     EYLDPRTGIFNGKLFDAILPFADMIVNMPLWIGSEGVGGRSHSYEESELTAILEGLERY
                     SGIEPRGKRTAIYDCYRNLKDQALDPRTAGLHDEEQYKQPDFPFKPFDPNRPLDWVWGY
                     SFMQKRPILVPESLAYYSLGREDSFVYETSNGCALGGTLEEAIFHAILEVVERDSFLLT
                     WFARLPLRQIELHSCEDEELRLMIERVRAVAGYDLYVFNSTMEHGIPSIWAIAKNRKQH
                     GLNLICSAGAHPDPSKAVKSALHELAGMMFKHDAKLEAERDKYEEMLHNPFLVREMEEH
                     SLLYGLPEAEERLRFLLEQNQPLTTFQEAFKQKTNNLDLKKDLEELLETFRRLNLEVIV
                     VDQTSPVTKRNGLYCVKVLIPGMLPMTFGHRLTRLTGLERVLTVPAKLGYRKETLTFDE
                     LNQHPHPFP"
     gene            complement(12232..13212)
                     /locus_tag="S101395_RS18865"
                     /old_locus_tag="S101395_03792"
     CDS             complement(12232..13212)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328966.1"
                     /locus_tag="S101395_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03792"
                     /product="aldose 1-epimerase"
                     /protein_id="WP_006636649.1"
                     /transl_table=11
                     /translation="MSSTIRNCRFLNEEAVLLENEYLEAILVPSWGSNLISLKWKPAGM
                     HLLKTPETKEEYHANPCLFGIPVLFPPNRIDHGTFTYEGKTYSLPINEKPLQNHLHGFL
                     YDKAWTLAKAEAEGRRGIAQTVLNAGKDPDIQRIFPHSFSIAITYTLEEHDLHIDASVV
                     NHGEEPMPLGLGYHTSFRYPFNHEGDKTECVFSLPASKHWDLSDRMLPTGEYSETDGFK
                     AGRTAAGERLDDMLAAEHDQAGNSTAEIRDRLAGIRLSYEGDRHFKHWVVYNGKTDHED
                     LLCLEPYTWMTNAPNLDLPADVTGFRALGPNEELTMRSKITIGGM"
     misc_feature    complement(13305..13319)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.1"
                     /tool="antismash"
     gene            13439..14800
                     /gene="nhaC"
                     /locus_tag="S101395_RS18870"
                     /old_locus_tag="S101395_03793"
     CDS             13439..14800
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nhaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019712919.1"
                     /locus_tag="S101395_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03793"
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="WP_006636648.1"
                     /transl_table=11
                     /translation="MSNEKRLSFSISAFLFFSILLIIFICLFVFHADPHMPLLICIGFL
                     AVVGVLQGFTWKDLENGIVSGIRSGVQPLIVLSLIGILIGVWEYSGAIPTVTVYALNII
                     EPQFLLLTALISCLIISSLVGSSFTTVSTIGVALIGVASAAGIPLTWVAGAVICGACFG
                     DKMSPLSDTTNFAAGVGELPIFKHIRHMTGTTIPALLITVLLFFFMGRSLTITSGSIDN
                     IRSIVNGIENTVDISFWTLLSPLLVIVLAVRRMPVIPSLAAGIVSAGIIAALIQPDAGI
                     SSFLSAMQKGPVFSAGSETVENILNRGGLQSMMGSISLIIIAFALGGLMEKTGLITSLL
                     EGVIKGIRSKGRLVFSTVSSSIAMNLLTGEQYLSILIPGQSFKNLYDKLGIDRKHLSRS
                     LEDGGTLVNPMIPWGVSGAFMSSALGVPVTDYLPFVFFLYLSPIFSILFGFRKQ"
     gene            complement(14841..15692)
                     /gene="dat"
                     /locus_tag="S101395_RS18875"
                     /old_locus_tag="S101395_03794"
     CDS             complement(14841..15692)
                     /EC_number="2.6.1.21"
                     /GO_function="GO:0047810 - D-alanine:2-oxoglutarate
                     aminotransferase activity [Evidence IEA]"
                     /GO_process="GO:0019480 - L-alanine oxidation to pyruvate
                     via D-alanine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_4 (43-271). E-value: 1.8e-43.
                     Score: 140.9. Matches aSDomain:
                     nrpspksdomains_S101395_RS18875_Aminotran_4.1"
                     /codon_start=1
                     /gene="dat"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020450756.1"
                     /locus_tag="S101395_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03794"
                     /product="D-amino-acid transaminase"
                     /protein_id="WP_006636647.1"
                     /transl_table=11
                     /translation="MKVLFNGRLMERSECAVDIEDRGYQFGDGVYEVIRIYNGSLYTLD
                     EHIARFFKSAAEIGIVLPFSEAELKGELKGLIKANQVDDGGLYLQATRGTAPRKHQYKP
                     GLTPQVTAYTFPIKKPVNEQENGVSVITEDDLRWLRCDIKSLNLLYNVMIKQKAHEASS
                     FEAILIRDGFVTEGTSSNVYAVKQNVIYTHPASNLILNGITRRTLLELFRKNGWQHEEK
                     AITKDELMNADEVFISSTTAEVIPVTVIDGQNIGTGAPGPLTKEVQKALQDNILSETAK
                     VL"
     aSDomain        complement(14880..15563)
                     /aSDomain="Aminotran_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S101395_RS18875_Aminotran_4.1"
                     /evalue="1.80E-43"
                     /label="S101395_RS18875_Aminotran_4.1"
                     /locus_tag="S101395_RS18875"
                     /protein_end="271"
                     /protein_start="43"
                     /score="140.9"
                     /tool="antismash"
                     /translation="LDEHIARFFKSAAEIGIVLPFSEAELKGELKGLIKANQVDDGGLY
                     LQATRGTAPRKHQYKPGLTPQVTAYTFPIKKPVNEQENGVSVITEDDLRWLRCDIKSLN
                     LLYNVMIKQKAHEASSFEAILIRDGFVTEGTSSNVYAVKQNVIYTHPASNLILNGITRR
                     TLLELFRKNGWQHEEKAITKDELMNADEVFISSTTAEVIPVTVIDGQNIGTGAPGPLTK
                     EVQKAL"
     misc_feature    complement(15822..15836)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    15907..15925
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.19"
                     /tool="antismash"
     gene            15995..16894
                     /locus_tag="S101395_RS18880"
                     /old_locus_tag="S101395_03795"
     CDS             15995..16894
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180166.1"
                     /locus_tag="S101395_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03795"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_006636646.1"
                     /transl_table=11
                     /translation="MRQDSRKTAPSVPYLLTKTACFAILFLILLYVWDLSQSPGASGKK
                     DLAMSENSEMRHEGDSIPLKKETHGKLLDHLSTKQEIAKRKVEKEQKKEAAEKKQEKTV
                     YLTFDDGPSAATQKLLEILDEQDVKASFFMLEPNMKLHSKAVLNMKQQGHALGLHGVTH
                     DQKQFYKGANSPNLEMKQAQNTLKSITGVKTRLIRTPYGSKPSLTEAQKKRLKKSGFIY
                     WDWNIDSLDWKYRNQRYVPEVMNQLNIIKNRHTKQPIVILMHDIPSTVQSLPLLITNLK
                     NMGYSFATLDESMTPVHE"
     gene            17030..17527
                     /locus_tag="S101395_RS18885"
                     /old_locus_tag="S101395_03796"
     CDS             17030..17527
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180165.1"
                     /locus_tag="S101395_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03796"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_006636645.1"
                     /transl_table=11
                     /translation="MEIEELTSLDSHIDTLSDLLVQVTDEGASVGFLPPLKRADALEYW
                     QTVLQPGVILLIAKQNGKIAGTVQLHLCMKQNGCHRAEICKLMTAPSFRRQGVARLLMK
                     NILERAKQEGRSLAVLDTREGDPSNLLYASLGFAKAGRIPEYAESADGSLEATVFYYKD
                     LR"
     gene            complement(17903..18652)
                     /locus_tag="S101395_RS18890"
                     /old_locus_tag="S101395_03797"
     CDS             complement(17903..18652)
                     /EC_number="2.3.1.286"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180163.1"
                     /locus_tag="S101395_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03797"
                     /product="NAD-dependent protein deacylase"
                     /protein_id="WP_006636644.1"
                     /transl_table=11
                     /translation="MDKEAETFLDLIDNARRITVLTGAGMSTESGIPDFRSAGGLWTED
                     MSRMEAMSRDYFERYPKLFWPKFKALFQMKMTGSFQPNAGHLYLAELEKRGKDVRVFTQ
                     NIDGLHVKAGSRHVYELHGSIQTARCPKCGAGYGLEHLLREEVPRCSRINQKGEACGFI
                     LKTDVVLFGDPVQHFDTLFDILADSDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMIN
                     LEKTPYDHLFDVVIHRKIAEFTKEISG"
     gene            complement(18686..19765)
                     /locus_tag="S101395_RS18895"
                     /old_locus_tag="S101395_03798"
     CDS             complement(18686..19765)
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180161.1"
                     /locus_tag="S101395_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03798"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_006636643.1"
                     /transl_table=11
                     /translation="MFTQYLTMEFAGQIGISIGILLLFFLLRKIFTKYLFNLILKLTHK
                     PKTDFFNQVAVAFEKPARWFFAILGIYLAIIYSPFFDAHMAIVHKLYRVSLVILVVIGL
                     YNVTASSSVLFHKINKRLELDMDDILAPFLSKILRFVIVALGISMIAGEFHYDVNGFVA
                     GLGLGGFAFALAAKDTVGNFFGGIVIIMEKPFTIGDFIETKIVIGTVEDITFRSTKVRT
                     AGEALVTVPNSVLANEAIMNWTKMRKRQITFSLHIDPSTPREKVERCVQRFREMLQTHE
                     GVHPDVIMVNLDVLQDTYLSIFFNFYTNTTVWAENLDIRQDINYRIIDIMKEEQVEFVS
                     PGHSLFELHDMKAALENQA"
     gene            complement(20000..20107)
                     /locus_tag="S101395_RS18900"
                     /old_locus_tag="S101395_03799"
     CDS             complement(20000..20107)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388844.1"
                     /locus_tag="S101395_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03799"
                     /product="YhdX family protein"
                     /protein_id="WP_006636642.1"
                     /transl_table=11
                     /translation="MGKGRIKVEERIKIETDAEMFKATLLDQTQSAKKK"
     gene            20340..21062
                     /locus_tag="S101395_RS18905"
                     /old_locus_tag="S101395_03800"
     CDS             20340..21062
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017695389.1"
                     /locus_tag="S101395_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03800"
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="WP_029419056.1"
                     /transl_table=11
                     /translation="MHIIAHRGASAYAPENTFAAFEKARELGAGFIELDVQLTKDGKLA
                     VIHDDKVDRTTNGTGFVRHFTMKELETLDAGSWFSPSFQGEKIPDLEAVLHKYHNKIGL
                     LIEIKSSKTQPGIEKAIGRLIDRLGPSANTIVQSFDAGAIMTLHNLYPSIPGAVLIRPR
                     FGMLPYGRLRHISSFARYVSLKHTMLSSFLIKSAHSHDMKVFAWTVNGRKTGRRLQSWN
                     IDGIITDYPDYFKKEGKA"
     gene            21059..21460
                     /locus_tag="S101395_RS18910"
                     /old_locus_tag="S101395_03801"
     CDS             21059..21460
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328971.1"
                     /locus_tag="S101395_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03801"
                     /product="CrcB family protein"
                     /protein_id="WP_006636640.1"
                     /transl_table=11
                     /translation="MKSYLAVFIGGALGSLCRYAINMSAGSAWFPWPTFIENASGSLLL
                     GLLTGFFSSRAKKPLIQLCLGTGFCGGYTTMSAFSKETALILQSAAPHNGVLYLVASLA
                     SGICLAFIGIVLGNRIGGQAGQKKERYTS"
     gene            21457..21807
                     /gene="crcB"
                     /locus_tag="S101395_RS18915"
                     /old_locus_tag="S101395_03802"
     CDS             21457..21807
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003180153.1"
                     /locus_tag="S101395_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S101395_03802"
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_006636639.1"
                     /transl_table=11
                     /translation="MMTAGFMIAGGIGSVLRFWLGNIIGSKFKNACIPASILIINILGS
                     LMLGIFVSLDIQQQMLSTVIGTGFFGGFTTFSTFSVEAVQLLVEKRLKAGAAYIILTMA
                     CCVGGFWAGSLV"
ORIGIN
        1 caaactgcgg gtgcagatgc gcgcggaaat caccaagctc catcagcgcc tgcaaacgac
       61 gacgatttat gtcacgcatg accagacaga ggcgatgaca atggcgacaa ggctcgttgt
      121 catgaaagac ggcctcatcc agcaggtcgg cgcaccgaag gaagtatatg aaaatccgga
      181 aaatgtcttt gtcggcggtt ttatcggctc tccggcaatg aactttttca ctggcaagct
      241 tcaggaaaat acctttacat tcggcgatgt ttccattctt gttccggaag gaaaaatgaa
      301 aattttgcgc agcaaaggct atatcggtaa ggaaatcatc atgggcatca gacctgaaga
      361 cattcatgac gagcccgtct tcctaaaagc ctcaaaagaa tcaaaaattg atgcaaaaat
      421 cgaagtggct gagctgatgg gcgccgaaac gatgctttat tcacaggccg gcgggcagcc
      481 gttcatcgcc agagttgatt cacggacaga tgttcaggca ggcgatgtcc acgctcttgc
      541 atttaacatg aacaaagccc atttctttga taaagacaca gagctccgca tccgctctga
      601 aggatgactt gcttcccgtc acttccggcc cccggcaata gagcgaatca gaaaattgac
      661 cgaagtgcgg cttctgctat gcttcggtca attcaatttc gactgtttca tcataagagc
      721 agtcttggca agtgtataaa tgaatacagc ttgaccgcgt ctgcaaaaac gaatcatact
      781 ccatatacgg gctgtaagga ccgtaaaaat cggttgttct tccggcgtcg gccatttcgc
      841 cgccgcacct cggacaagct ctttcctcca ccagaatccc attgcataca ggacacattc
      901 ggcatcctcc ttatcttttc ctttagattg cccctttcgc tgaaatttcc gctttcaaca
      961 tttaccagtt tgtactgcgc atggatttga ttgaatccac cataatacgt agtagcaagg
     1021 cagcattggg ttcagccata gaaggcagct gttttcccct ttggaaagcc gccagctggt
     1081 gcaaatccag ccaacccaac catactatct gataaaggag agtttgatac aatggctaac
     1141 caaaattctt caaatcaatt gctcgttcct ggagctgctc aagcgatcga acaaatgaaa
     1201 ttcgaaatcg cttcagagtt cggtgtaaac cttggtgctg aaactacttc ccgcgcaaac
     1261 ggatctgtcg gcggagaaat tacaaaacgt cttgtttccc aagctcaagc ttctatgggc
     1321 ggacaacaat aaccatcaac ttcatatcat ggctaaagct gaaggtgctt cacagcacct
     1381 tctttttgca tgggaaaatc ccgcacccgc catctccgtt ttacatatgc tgatgtaaag
     1441 gaggagtcgg catgcagctt gtcacaagca tcaattggga actgcttcaa tttgtcggga
     1501 tttccctttt gcacgaatat ctcatcaata tccggccttt tcaggcggtc tttcgcttct
     1561 ctggggcttt ttctcccggt cgatctgacg tatgatagat caaatgggag ggattgttga
     1621 tgaagattgc actttttgga ggtacaggcc gtgtcggacg agctttcctg cactttattg
     1681 aagcaggcgg cagacactcc gtctctgccc ttgtccgcgc ggaacatccg aaccttccga
     1741 gcacatgctg ccgcacattc cgcggaaacg caagaaatcc ggaagacgcg caagctctca
     1801 ttaaagaggc ggatatagtt gtcagctgtt taaatacaga tggagacgat acattaagcg
     1861 tctccatcca aaacatcata aacgctatga gcgcccaaaa caaaaaaagg ctgattacga
     1921 tcggaaccgc cggaatttta caatcgagac aaaacccggc gctttaccgc tttgaatcaa
     1981 acgaatcaaa aaggcgctca tcacgcgcgg caaaagaaca tgcaaacgtg tatgaacgcc
     2041 ttctggcatc agatttgaat tggacggtta tttgcccgac ctatcttccg gacggtccgg
     2101 ccgtgacaaa ttaccgcgtc gaacggaatt ttctgccgat tggcggcaaa gaaatatcaa
     2161 ccggcgatac cgcccatttt ctttacaaac agctcaactc agacgagttt attcgggcaa
     2221 gggccggact ggcgtattaa catgctgggg caagccggga atgcccggct taccctacaa
     2281 gcgttccgcg tcctttttga agttcataca tttgataata ttgccctttt tgcttcataa
     2341 gctcctcatg tgagcccttt tcaatgatcc gccccttatc aagcacaagg atttgatctg
     2401 cctttctgat ggtcgatagc ctgtgtgcga tgataaaggt cgtgcggcct tttttgacta
     2461 cgtcaagcgc cttttggatc acagcttcag tttcggtatc tatatttgcc gttgcttcgt
     2521 ccaacacgag gatcgccgga tcataagcaa gcgccctcgc aaatgaaatc agctgccttt
     2581 ctcctgagga gagcgtgctt cctttttcaa tgacaggctc atcaaatcct ttcggcaggt
     2641 gggcaagcag tttatcagcc cctacttgct tcaatgcggc ttcaatctgc tctcttgtga
     2701 ccgcctcatg atcaaggttg acatttgaag caatcgtacc ggaaaacaag taagggtcct
     2761 ggagaacgat gcccatatgc tgtctgacat cctggcgcga catatcataa atgcttgttc
     2821 catcaatttt gacatcgcct ttttgtatat cgtagaagcg gaacagaaca ttcataatcg
     2881 agcttttgcc tgatcctgta tggccgacca atgccacggt ctccccttgt ttcgcttcga
     2941 atgaaatgtt cttgagcaca tattccccgc tgtcaccata ccgaaatgag acatcctcga
     3001 aaacaacatg accattcact ttaactccac ttgtttcctc aacatcaact ccaggttcat
     3061 ccaaaaggcg aaatacccgt tcagatgata ctctcgcaag ctcaagcttg ggaaattggt
     3121 tgacgatccc ggtaatcggc tgaaacagac gagtcaggta atcgacaaat gcatagagca
     3181 caccgatcga catcattccc tccatcttca gcgccgctcc cccgaaatac cagattaaaa
     3241 cggcgaacat gacattctgc agaacattga caaggttatg ggacattaac gaattcaaat
     3301 tgagcatttt gttttgatag tgaaaatggc tgtcgtttaa ttcttcaaat tcacgcttta
     3361 tatctttttg ccgccggaag acctggataa tcggcatccc ttgaaccgct tcattcattt
     3421 tggcgttaat atcgctgttg atcgatctga gtttatgatt gtagcctgaa gcaaattttc
     3481 ggtagacggc cgcccaaatg gcgatcagcg gcaatatcag caagcagacc gccgccagtc
     3541 tggcatcgag cagaaacaaa gcggcaaaaa ttccggccat ataaatcatg tctgtcacaa
     3601 atgtcgaaag aacagtcaca taaagatcgc gtatcgcttc cgtgtcattt gtcacccgcg
     3661 cgaccacttt gccggccggc aaattgtcaa aatagcggac aggcagcctt tggatattgg
     3721 caaacacatc ctggcgcatt ttctgaatga tgcggtttgc gctcatctgc aaaagataaa
     3781 actggccgta atgaaaaaag atcgacagga tgagcagtcc cagatacagc aatatgagcg
     3841 acacaagccc tttcatttcg ggttcgtaaa atgaaaaagc ctcagacgct gacagccgga
     3901 cggccgggta ggattccgac tgtcctccgc tggagatccg caataccccg tccttcaccg
     3961 tcctttttcc atcaaaagga acagcttcat ctacaaaata atacgtcatg ccgatttgaa
     4021 aaacgcggac ttccttccgc ttttccagcg aaggatcggc cctgtcggct ctgacatatt
     4081 cccttccgtg atacgggact gtatattcgc tttttcctga aacttcatac cacggttttt
     4141 gaatcccgag aatatgatcg tcaatcattt ttttgccgat catcggccct gtcagctccg
     4201 cagtgacggc cgccgtcagc ataagaagag cgcagatcag gatgttttta taacagagcg
     4261 catattgaaa aagccgtttt ccagtcttca tgccacagtc cccccttcat cccctgaagg
     4321 cagctgctgt gcttcatatt gttcaaaata ccagccttta cctgcgatca gctcctgatg
     4381 cgtgccacgc tctgaaatct tgccgttctc cattacgaga atgaaatcgg catgctcgac
     4441 tgctgacatg cggtgcgatg taataaatgt cgttttgcct tcccggtgat gacggatatt
     4501 ttcgataatc gccgcctctg ttttcgcatc tacggctgag agcgaatcgt ccaaaatcaa
     4561 aatgtccgga tctgcaatca aggctctcgc aatcgaaatc cgctgttttt gtccgccgga
     4621 taatgccacc cctttttcgc cgaccatcgt ctcaagcccg tcagaaagca gttcaatatc
     4681 cttttccaaa tgggctgccc ggatcacgtc agctacatcc tgctctgtcg cgtgtaatcc
     4741 gccgaacaat atgttttctt ttaccgtttt tgaaaacagc acatgatcct ggggcacata
     4801 tccaatccag ctgtgcagca gatcaagggg cagatcccca atcggcacac cggaaatggc
     4861 gagcgttcca tttccctcgg gatactgtct taaaagctgc ttgatcagcg tcgttttgcc
     4921 gcttcccgtc tttccgacga ttccaacagt ctgtcctttc aagactgcaa acgaaatccc
     4981 tgaaaggttc tccgagcttg agcttggata cgtaaaactg actttgtcaa agacaatatc
     5041 cccaggttca gctcttttgg gatgaggcgc ttcttttaca tcaggctgat gacgcaatgt
     5101 ctcattcacc ctatcgaggg acgcgttgcc tctttgcatg atattgatca gctcgccaat
     5161 cgcgaacatc ggccagatca gcatccccaa gtaaacatta aaagagacga gctcccccaa
     5221 tgtcagctgg ctgcgaaaga caaggtaggc gccgtagccc aaaccgatta aataactcat
     5281 cccgacaagc agcttcaccg tcggttcaaa cagcgaatcg atcagcgcca ccttcatgtt
     5341 tttttgataa acatcagctg tcatgctgtt aaaccggctg acatcgtttt tttcctgcac
     5401 ataggccctg atcaccctta cgcctgatac tgattcaagc acctgatcat ttaattcgcc
     5461 aaacgcattc tgcgcttctg taaaacgctg atgaattttt ttcccgtata caccgatcgc
     5521 cgcggccatc aatgggagag gaatgatcga tgcaagcgtc agcttccagc tgatcaaaaa
     5581 tcccattgta aacagaatcg tcagcataaa catcgttgag tcgacaagcg tcaatatccc
     5641 gaaaccggcc gtcatcgaga tcgcttttaa atcatttgtc gctcttgcca tcaaatctcc
     5701 ggtgcggttc ttctcgtaaa aagcgggcgt cattttcaac aagtggccca tcagttttga
     5761 cctgaggatt ttttcgatca gattcgcccc gccaaacagc tgatacatcc agttgtatga
     5821 cagcgtataa acaacaaggg agagtccgat caataaaccg atataaccgg ccatcgccat
     5881 tgccgaaaaa gcgcccgtct gcatatcgtc aatggcgttt ccaagcagtt tcggcggaaa
     5941 catttccagt atattcacca tcaataacag gacgatcgcg attgtatagc gccgccatga
     6001 ggctttaaaa aaccagccga gcttccataa aacagaaaac atgtgatatc ctctcctttt
     6061 ttagccgcct tcgagctttt ccttgcagtc attgatctcg ctttttctta catttggcat
     6121 aaaaaattcc tccttttact attcgaaaat tcagtcggat ccgccgaatt ttcatttatt
     6181 agaaaaacat ccgcaccata ttggagacgg aatgttttat ctccgaaaaa aaaggcacac
     6241 tgtacgagca gcatgccttt tcgatataaa aaaggcgcat gtacgaaaga tgaacgtgac
     6301 atgcgccttt cctcaaatat tatttagaaa ccgtctgtaa agaatatgga aggtgtaaag
     6361 ccgccacgtt ttgattcagt tgtctgctga ttgatgaatt gattgctctg atcatgacgt
     6421 tgccctccat tcttattaat attttccatc ttatagcacg gttttttatt tgtcaatttc
     6481 atttcttcat aaattggaag aatctttatt catatgttca aattccgtta gtttttttga
     6541 aaatcgggta taacgataat aaatccattc tgaaaggaat gatcaatgtg tttacagcta
     6601 accggatcat tgtcgcgttt gacggaaaag acgacagtaa gaaagcgctc aaaaaagcga
     6661 tagacctcac caaaaggatc ggcgctgaac tgaccatcgc ccacgtccat gaaccgaggc
     6721 aagccaaacc tctggcaaat gaacaaaggc cggccgccgg cacggcttat atctacggcg
     6781 gcatccccag cgtccccccg gttccgcgcg agtcggatat tgcgggagaa cccgtcattt
     6841 acgaggacag cacagaggaa gcgatcgcag cggccaaaat cattttaaac gaacaccaat
     6901 tcgacgccaa cattgaaatt cttgaaggcg accccgccaa tgcggtcctg cggcacgccg
     6961 aacacttcgg cgccgacctc gtcatcacag gaagccggga ccaaaaccgc ctgaaaaaac
     7021 tgctgttcgg aagcgtcagt gataaaattt ccgcaaaatc ggaaataccg gtgctgattg
     7081 tgaaataaat ggggctggat attttccggc ctcttttttt cgtttatgag aggaccgcca
     7141 ataagcgagc ctttcaccat ttcacggtgt tcaatttttt ctcttacatc tagtttcatc
     7201 cccaaacaat ctcttctagc aaatagaaac tgaaaactca atttcaaacc atgatcatct
     7261 taatgataaa actcaaataa aacagcaaaa agaccctaat aaaccatgaa ggtatgagcc
     7321 cctccaagaa atatccatga tttatctttt ctctatctca ttacaaccgt acagataata
     7381 aaaaaggcat tatgttaggc gcaacccgct ttactatctt tttcgttatc tcaatcggtc
     7441 tgcatgacca gattggacag ttcacttttc aattctctct atccatttct ttcaaagaat
     7501 gaattctagc agtccttttc cgcaaaacag agaaaatccc acaaatccaa ttacaggaaa
     7561 ataggcgttc aaatcagtaa caatcaccta acaagtctca tagtttgatg ttgaatgtgc
     7621 ctggggcatg tcgttcattt ttttctattt ttatgttgtg gtctgattgt ttttaaaaaa
     7681 cttttattta tttctggagg gatatgtcaa tgcaatattt tcatgatgaa ttgcaatcat
     7741 taggaatgga tcatttccat gtggatgaga tgacggcttg ggatccaaac cgtcatgagg
     7801 taaatgctaa acactgtgca agctgttgga gttgtggaag ttgtgcgagc tgtgcaagct
     7861 gctggagttg cgcgagctgt gcgagctgct ggagctgtgc gagctgctgg agctgcgcga
     7921 gctgtgcaag ctgctggagc tgcgcgagct gttggagctg tgcaggtcat tgttgttgga
     7981 gctgcggaag ctgctggcat ggaggaggta tgtagcttta agaagcagac tgcccctgcc
     8041 tttactgccg caggggccca ttaatcataa cggacaacaa aattacatat actggtatgt
     8101 cttgttttaa gatgatctaa aggaggtaca gcatgacgaa tctgaccgct tccgcccgcc
     8161 tgaaggtgaa acaggataca tgttttcttc cggacccggc tggcggcgtg tatgttcgaa
     8221 ataattcagg atcgtttcgt atgaaagggg cgtccattta tcaatggata gaaaaattgc
     8281 tgccgatgtt caatggtgaa catacactgg aagaattgac aaatggactg cccgcaccct
     8341 accgtgacag agtgtttgat attggaggga tgctgtataa aaacggattt gttcgggacg
     8401 taagccggga ccgcccgcat caattagagg agaacgtact caagaaatat gcttcacaaa
     8461 ttgaatttat agaaagcttc gcagattcgg gcgcttatcg cttccagcta tgccgccagg
     8521 caaacatatt ggctgccggc tccggctctt ttctcatttc actggtcaga tcattggctg
     8581 aatccggttt cgccaaaatt catgtttttt ttacagaagc acgctctgac catcagacag
     8641 ctttagagga gctggaggct tatgcgagac aggctgatgg cgatatgatc gagctgactg
     8701 ctgtacaaga ttggcgggaa gccgtcaaat cctgtgattg gattttatat gcttcagaaa
     8761 ttgacgatcc ggagaaactt cttgcgcttc aaagcgtttg cagggaagaa aagaaacgct
     8821 tatttcccgc ggtctgtctg aagcagatcg ggctggcagg ccctttcgtg catcaagacg
     8881 gcgacggatg ctttgaatcg gcatggcggc ggattcaccg ttcggcgctt caggaggagc
     8941 ggaaggttga cacctttcct gcggctggaa aagacatgct ggcgaatgtc attgtgtttg
     9001 aattgtttaa aacggtttcc gggcttgctt cattaacaaa gcgaaatgaa tgttatcttg
     9061 tcgacctctc cactcttgaa ggagtctggt gcccgttcct cccccatccg ctcgtcagct
     9121 ccgacggcgg catggctgaa ttggttcgcg atattgaagc aaaggtgcaa aatcgctcca
     9181 aaccgaaaga aaaaggacgg ctttttcaat tgttcagtca gctgacatcg gaaaaagcgg
     9241 gaattttccg cctatgggaa gaaaaacact tgaagcagct ccctctttcc caatgcttcg
     9301 ttcaagttgc aaatccgctc tcagaaggac cggccgagct tttggagaag acggtctgct
     9361 ccggttttac ccatgaggag gcccgcagag aagccggact gaagggcatt gaaatgtatg
     9421 gggcaaaact ggcggatgtc tctgtcattg aggatggttt cttaggcatc ggaacaggag
     9481 aaacgatcgc tgaaagcgtg ctgcggggat tgcaaaagtc gcttgacgct gaattgcaga
     9541 agcgggcaaa aagcggagga gaaacggcct ctcctctttc tatcggcatg atcaacgata
     9601 aacgagccgc attttatttg aatgcgctgt ctatcatgca cggcacacct gagattggct
     9661 tgggaaagga tatatcaggc tttccagttg tatggacagg tgtgtgcggc cgctggtatg
     9721 gaagtgcggg aatcaatata acattggcgc ttagaaacgc actgcaacag gcgctcatga
     9781 acacacggcc gcttgaggag gccgctgtca ttttaacgga aaacaagatc aggctcgaca
     9841 tcccggtttg tgaagaccac acacaactgc tcgatacggc attgaaaagc atcagacgca
     9901 acgggttaca gctgctcgtt tatgatgtgc cggctgagcc ttttttcgaa aaagcactcg
     9961 caggcatcta tgctgtgcgg ttaaaaaagg aggaggcttg atggaacgct gtattttgct
    10021 tgttggggaa ggcatgatcg cagatgatgt gtcaaaacaa ttatccggcc ggtatcgagt
    10081 gcttcgccag cctgatgtta aggcgggaat tcccggggaa accgggcttg ttcttatcgt
    10141 gcatgatgcc tggcgcccgt ccgtatatca cgaggcggaa gccatattaa ggccagcggg
    10201 aattccatgg cttcgcggct ttgtttcatt tggtgaaggt gtcatcggcc cccttgtgtg
    10261 tccggaggac gccggctgct ccagctgcgc tgatatgagg cggttcatca ccggccccga
    10321 cagcacagaa atgcggatgc tcatgcagca aaatagggat tttcaccgtg acccctgggc
    10381 atctcaggca ggatgccgcc atatggtccg cttgatctgt acagagatca aaaacatgat
    10441 ggagaatggc cggagccgtt taaaaaacaa gctgtggctg atcaatttca aaacattgga
    10501 ttgctcctta cactctgtta tgcctgaacc gctctgtgag gtctgcggcc gattgcctga
    10561 cgatacagcg gaatcggccc tgatttcgct taaaccggct ccaaaaacgg ggccgggcag
    10621 ctaccggacg cggcggacag atgatttgca agatgtgctg agacaagaat acctcgatcc
    10681 caggacggga atcttcaatg gaaaattatt tgatgccatc ctgccatttg ccgatatgat
    10741 cgtcaatatg cctttatgga taggaagcga aggtgtcggg gggcgaagcc attcctatga
    10801 ggaaagtgaa ttaacggcta ttttagaggg cttggagcgc tattccggaa tcgagccccg
    10861 cggcaaacgg acggcaatct atgattgcta ccgcaatctc aaagatcagg cgctagaccc
    10921 aagaaccgcc ggactccatg atgaagaaca gtataaacag cctgattttc ctttcaagcc
    10981 atttgatcca aatcgtccgc ttgattgggt atggggctat tcttttatgc aaaagcggcc
    11041 gatattggtt cccgaatctc tcgcctatta cagcctgggc cgtgaagaca gctttgttta
    11101 cgaaacgtcg aatggatgtg cattgggcgg gactctggaa gaagcgattt tccacgccat
    11161 tttagaagtt gttgaacggg attccttttt gctgacttgg tttgccagac ttcctctccg
    11221 ccagattgag cttcattcat gcgaagacga ggaattgaga ttaatgattg agcgggtgcg
    11281 cgccgtggcc ggatatgacc tgtatgtgtt taattcaacg atggagcacg gcattccaag
    11341 catctgggcg atcgccaaaa acagaaaaca gcatggcttg aatcttattt gctctgcggg
    11401 agcacatcca gatccctcta aagcggtcaa aagcgcacta catgagcttg cggggatgat
    11461 gttcaagcat gacgcaaaac tcgaggccga aagagacaaa tatgaagaga tgctccacaa
    11521 tccttttctc gttcgggaaa tggaggaaca cagcctgctg tacggtttgc cggaagccga
    11581 ggagcgcctt cggtttttgt tggagcaaaa tcagccgctt accacctttc aagaagcgtt
    11641 caagcaaaag acaaacaacc tggatttaaa aaaagatctt gaagagcttc tcgaaacatt
    11701 ccgccgactg aaccttgagg tgatcgttgt tgaccaaaca tcgccggtca caaaacgaaa
    11761 tggcttgtat tgtgtgaaag tgctgattcc cggcatgctg ccgatgacat tcgggcaccg
    11821 cctcacccgc ttgaccggtc ttgaacgggt tttgacagtg ccggcaaagc ttggctatag
    11881 aaaagagacg ctgacattcg atgaactgaa tcaacatcct cacccgtttc cttaaaactt
    11941 gcatgttttg atcgttctgt tttacgataa ggcggaaatt ttaggcgact ccaatgaaac
    12001 aggagtacaa acggcccatc gttttgaccg gggccgtttt catgatcgtt tgttttttta
    12061 tttcagcgga tgctgatggc ttttcactct tgggaatatc caaaatgaat cagaaaagcc
    12121 gggaacatta acattggacg tgtaaacccg gcaaacttgc tgatacatag ttggaatctt
    12181 ctttgcagga tttgagatga agttgagcca aactctgggc ggaatgaacg cttacattcc
    12241 gccgatcgtg attttgcttc tcattgtcag ctcttcattc ggacccaaag cccgaaaacc
    12301 ggtgacatca gccggaagat caaggttcgg ggcgtttgtc atccatgtat aaggctcaag
    12361 gcaaagcaag tcttcgtgat ctgtctttcc gttatagacg acccaatgtt taaaatgcct
    12421 gtctccctca tagctgagac ggatgccggc caggcggtcg cggatttcgg ccgtgctgtt
    12481 tccagcttga tcgtgttcgg ccgccaacat atcgtccaga cgttctccgg ccgccgttct
    12541 ccctgctttg aaaccgtctg tctcgctata ttcccctgtt ggaagcatcc ggtctgacag
    12601 atcccaatgt ttcgaagccg gaagtgaaaa cacacattcc gttttatccc cctcatgatt
    12661 aaacggatag cggaatgaag tatgatagcc aagcccgagc ggcatcggct cttcaccatg
    12721 attgacaaca gacgcgtcga tatgtaaatc gtgttcttcc aatgtatagg tgatcgcgat
    12781 cgaaaatgag tgcggaaaga ttcgctggat atcaggatcc ttgccggcgt tcagcacggt
    12841 ttgcgcaatt ccgcgccttc cttcagcctc cgctttcgcc agcgtccacg ctttatcata
    12901 aagaaatccg tgcaaatggt tttgcagcgg tttttcattg atgggcagtg aataggtttt
    12961 tccttcataa gtaaacgttc catgatcgat ccgattcggt ggaaaaagga ctggaattcc
    13021 gaacaaacat ggattggcgt gatattcttc ctttgtttcg ggcgttttta atagatgcat
    13081 tccggcaggc ttccacttca atgaaatcag attgcttccc cagcttggca caagtatggc
    13141 ttccaaatat tcattttcca gcaaaaccgc ttcttcattt aaaaaccggc aatttcggat
    13201 cgtactggac atccttcatt cctcctatat tgaaacgatt cggtgcaggc atgcacacaa
    13261 tcaattatgc ttgcctgagc ttattatatc taaagaagtg agcgctttca aaaagagaaa
    13321 tgaaaaatgt ttgaaatatt ttaatttagg tcattcttct ttttttctgt tataatacgt
    13381 ttacgcacaa aagcataaaa gtattaaaga atgatatttt cttaatgagg tgtatgattt
    13441 gtccaacgag aaacgcttat cgttttccat atcggctttt ttattttttt cgatcttatt
    13501 gatcattttt atctgtttgt ttgtttttca tgcagatccg cacatgcctt tattgatctg
    13561 catcggattt ttagcggttg tcggcgtcct gcagggcttc acatggaagg accttgaaaa
    13621 cgggattgtc tctggcattc gcagcggcgt tcagccgctc attgtcctgt cgctgatcgg
    13681 gattttaatc ggtgtttggg agtacagcgg agcgattccg acggttacgg tatacgcttt
    13741 gaatatcatc gaaccgcaat ttttgctgct gaccgcttta atcagctgtc tgattatcag
    13801 ttctcttgtc ggttcaagct ttacgacggt aagcacgatc ggtgtcgctt taatcggcgt
    13861 tgcctccgcc gccggaatcc ccctgacatg ggttgccgga gccgttattt gcggagcttg
    13921 cttcggggat aaaatgtccc ccttatccga cacgactaat ttcgccgcag gcgtcggtga
    13981 gctgccgatt ttcaagcata tcagacatat gacgggaacc acgatacccg ctctgttgat
    14041 caccgttctg ctgttctttt ttatgggacg gtccttgacc atcacatcgg gatcaataga
    14101 taacattcga tcgattgtaa atggaattga aaatactgtg gatatcagct tctggaccct
    14161 tttgtcgcct ttattggtga tcgtgctggc tgtaagacgg atgcccgtta ttccgtctct
    14221 cgctgcgggg atcgtgtcgg cgggtatcat cgccgcattg atccagccag atgccggcat
    14281 ttcctcattc ttatcggcga tgcaaaaagg accggtgttt tcagcaggaa gcgaaacagt
    14341 tgaaaatatt ctgaatcgcg gcgggctcca gtcgatgatg ggctccatct ccttaatcat
    14401 catcgcgttt gcgctcggcg ggctgatgga aaaaaccggg ttgattacaa gcctgcttga
    14461 aggcgtgata aaggggattc gatcaaaagg acgccttgtg ttttcaacgg tttcatcaag
    14521 catcgccatg aatctgctga caggcgagca atatttatcg attttaattc ccggacaatc
    14581 ctttaaaaat ctttatgata agctcggaat tgaccggaaa catttgtcaa gatcgctcga
    14641 ggacggagga acgttggtaa atccgatgat tccgtggggc gtcagcggcg cgttcatgtc
    14701 aagcgcgctc ggcgtgcctg tcactgacta tttgccattt gtgttttttc tttatctatc
    14761 accgatcttt tcgattttgt tcggatttcg aaaacaatga aaaaagcgcc gtttccagct
    14821 gcggaagcgg cgttttcttt ttacagcact tttgctgtct ctgacaaaat gttgtcttgc
    14881 agggcttttt gcacttcttt tgtgagcggt cccggcgccc ccgttccgat attctggccg
    14941 tcaataacgg tgaccggaat gacctctgct gtcgtcgatg aaataaacac ttcatccgca
    15001 ttcatcagtt catcttttgt tatcgctttt tcttcatgct gccagccgtt ttttcggaac
    15061 agctccaaca aggttctccg tgtgataccg tttaaaatga gatttgacgc agggtgtgta
    15121 tagatgacat tttgtttgac ggcataaacg ttcgaagacg tcccttccgt cacaaatccg
    15181 tcgcggatca aaatcgcttc aaatgaggaa gcctcgtgcg ctttttgttt gatcatgaca
    15241 ttgtacagca gattgagact cttaatatcg catctcagcc agcgaagatc gtcttccgtt
    15301 atgacggaaa caccgttttc ctgttcgttc acaggttttt tgatcggaaa cgtataagcc
    15361 gtcacctgag gggtgagccc tggtttatac tgatgctttc tcggagccgt tcctcttgtc
    15421 gcctgcagat aaagcccccc gtcgtccact tggttggcct taatcagccc cttcagctcc
    15481 cctttcagct cagcttctga aaacggcagg acaatgccga tttccgccgc gcttttaaaa
    15541 aaacgggcga tgtgctcatc aagcgtataa aggcttccgt tgtaaattcg gatcacttcg
    15601 tagactccgt ccccaaactg gtagcctctg tcttcaatat caactgcaca ctcgctccgt
    15661 tccatcagtc ggccgttaaa aagaaccttc atttctccat ccccttgttc tttagttggt
    15721 tttctcgatt ttctcccttc cattctaaca tgccggtttc attctaaata gtgtaagatt
    15781 tcgaaaaact tttccttttc atcaaagcgg tttttggccg ctggacgaca gcatcctcca
    15841 tcattcagca tttttcctta acatttgcta gaaattttgc ggcaccggta ttcaacttct
    15901 ttccaatcct gtatacttaa acactgtggt ccattatttt atcagattag cagtctattc
    15961 ataatggatt aagaaatgat atggagagag tcacatgcgc caagattcaa gaaaaacagc
    16021 gccttcagtg ccttatttgc tgacgaaaac agcatgtttt gccattctgt tcctcattct
    16081 tctgtacgtc tgggatttat cgcaatctcc cggcgcatcc ggcaaaaaag atctggccat
    16141 gtcggaaaac agtgaaatga ggcatgaagg ggacagcatt ccgctcaaaa aagaaacaca
    16201 cggcaagctt ctcgaccacc tgagtacgaa gcaggaaatc gcgaaacgca aagtggaaaa
    16261 agaacagaaa aaagaagcgg cggaaaaaaa gcaggaaaaa acggtttatt tgacttttga
    16321 tgacgggcct tcagcggcaa cccaaaagct gcttgagatc ttggacgaac aagatgtgaa
    16381 agcgtcattc ttcatgcttg agccaaacat gaagcttcac agcaaagccg ttctcaatat
    16441 gaagcagcag ggccatgcac tcgggcttca cggggtgacc catgaccaga agcagtttta
    16501 taaaggcgcc aattctccta atctggaaat gaagcaggca caaaacacgc tgaagtccat
    16561 tacaggagtg aaaacccgtc tgatcagaac gccgtacgga agcaaaccgt cgctgactga
    16621 ggctcaaaag aagagattga agaaaagcgg gtttatttac tgggattgga atatcgacag
    16681 tcttgactgg aaatacagga accaaagata tgtcccggaa gtgatgaacc agctgaacat
    16741 catcaaaaac cggcacacaa aacagccgat tgtcatttta atgcatgata ttccttcaac
    16801 tgttcagtca ttgccgctat tgatcaccaa tttgaaaaac atggggtatt catttgcaac
    16861 ccttgatgaa tcaatgacgc cagttcacga atagccaatg tcaagatccc cttttttaag
    16921 gggatttttt tttattttga agctggtcag tttttctgac acattcgttg cactcaaaaa
    16981 aacttagact atattaggta gatagattga tataaaatga ggtgttcaga tggagattga
    17041 agaattgaca tcgcttgata gccatatcga taccctgtca gatctgctcg tccaagtcac
    17101 agacgaagga gcttcagtcg gctttctgcc tccgctgaag cgggcggatg cattagaata
    17161 ctggcagacc gtattgcagc ccggcgtgat tttgctgatc gccaaacaaa atggcaaaat
    17221 tgcaggaacc gttcaattgc atttatgcat gaaacaaaac ggatgccaca gagccgagat
    17281 ctgcaaatta atgacggccc cctccttcag gcggcaaggc gtcgcccgct tattaatgaa
    17341 aaatatcctc gaaagagcaa aacaggaagg cagatctttg gcggttcttg atacaaggga
    17401 gggagacccg tccaatcttc tgtatgcttc actcggattt gccaaagctg ggcggatccc
    17461 tgaatatgca gagtcggcgg acggcagtct ggaagcaacc gttttttatt ataaagattt
    17521 acgataaaac cgtggaagag gtcatcataa acctgaaatg aaaatgaaaa agacgtacca
    17581 tcattcatca gctgataatg gaggcgttcg cggaatatcg ctgtcttgac gtcccgtcgg
    17641 gcggaccgac agaaacggct gcaacggtaa aaacagcgct ttgaaacggc gaggaacagg
    17701 ctctctgata cgttttcgct cggttcagcc agatgcagcc tgaaggacga ccgctgaaaa
    17761 aaatcgaatg cgttgtcagg gcatctctcg ggatatggcg tcataaaagt gaaagatgcc
    17821 atcaatccga acggatgtgt agtcaagaca gcgcagttcg aaaaaacaaa tgaagaggcg
    17881 ctccctccgg gaagcgcctt ttttaaccgc ttatttcttt ggtaaactct gcgatcttgc
    17941 ggtgaatgac aacatcaaac aagtgatcgt acggggtttt ttcaagattg atcatggctt
    18001 tctttaaacc cgggatcaga tgcgcttcct ctgggacaaa gcggacagga gccacttcaa
    18061 gcgaggtgcc gattaccaaa agcaggtcag agtcggcgag aatgtcaaaa agggtgtcaa
    18121 aatgctgcac ggggtcgccg aacagcacga catccgtctt caatataaaa ccgcaagcct
    18181 cccccttctg attgatgcgg ctgcatctcg gaacctcttc ccgcaataag tgttccagtc
    18241 cgtagcccgc cccgcattta gggcatcttg ccgtttgaat ggagccatgg agctcataga
    18301 catggcggct tcccgccttt acatgaagcc cgtcaatgtt ctgtgtgaac accctcacgt
    18361 cttttccccg cttctcaagc tctgctaaat acaaatgtcc tgcgttcggc tgaaacgaac
    18421 cggtcatctt catttgaaaa agcgctttga acttaggcca aaagagcttt ggataccgtt
    18481 caaagtaatc gcggctcatc gcttccatcc ttgacatatc ctccgtccat aacccgccgg
    18541 ctgaacgaaa atcgggaatt ccggattcgg tgctcattcc ggctcccgtt aacacggtga
    18601 tccgccgcgc gttgtcaatc aaatccaaaa acgtttctgc ttctttatcc atgctggcgt
    18661 ccctcccttc ccttttaaac gatcatcaag cttggttttc gagagcggct ttcatatcgt
    18721 gcaattcaaa caggctgtgt ccgggagaaa caaactcgac ttgctcttcc ttcatgatgt
    18781 cgataatccg gtagttaata tcctgcctga tatctaaatt ttcggcccat acggtcgtat
    18841 ttgtatagaa gttaaaaaag atgcttaaat acgtatcctg caatacatcg aggttgacca
    18901 tgatcacatc cggatgtacg ccctcatgtg tttgcagcat ttccctgaac cgttggacac
    18961 acctttcgac cttttcccgc ggtgttgacg gatcgatatg cagcgagaac gtgatttgac
    19021 gcttcctcat ttttgtccag ttcatgatcg cttcattggc gagcacagag tttggcactg
    19081 tgacaagagc ctcccctgcc gtgcggacct ttgtgcttct aaatgttata tcttcgaccg
    19141 tcccgatcac gatttttgtt tcgataaagt cacctatcgt aaaaggcttc tccatgatga
    19201 tgacaattcc cccgaaaaag tttcctacgg tatcttttgc cgcaagagca aaagcgaatc
    19261 cgccaagacc aaggccggcg acaaaaccgt tcacatcgta atgaaactct ccggcaatca
    19321 tgctgattcc gagggccacg atgacaaagc ggagaatctt tgacaaaaac ggcgcaagaa
    19381 tgtcatccat gtcaagctcc agccgcttgt tgattttatg gaaaagcacc gaagacgaag
    19441 ccgttacatt ataaagcccg atcacaacga gtatgacaag ggataccctg tacagcttat
    19501 ggacgatcgc catatgcgca tcaaaaaacg gcgaatagat gatggccaaa taaatgccga
    19561 gaatggcaaa aaaccatctc gccggctttt caaatgcaac cgccacttga ttaaaaaaat
    19621 cggttttcgg tttatgcgtt aattttaaaa tcaggttaaa caaatacttc gtaaagattt
    19681 ttctcaataa gaaaaataaa agcaggatgc cgatgctgat tccgatttga ccggcaaact
    19741 ccattgtcaa gtactgtgta aacatcgctt tctctcctta tatcgctgtc aagcatttat
    19801 tatactaaaa gcttcgaaaa atttctcatt ttattgcgcg gcaaaatgtg acaggacggt
    19861 tatggacgga agaggaagag gattttcctg cttttgcgtc aggattccta ttctccgcat
    19921 aaaaggccgc cgatattttc ggcagccttt gtcgatcgta tgttattgtt ccaagagaca
    19981 tttgattcgg gctatactgc tattttttct tcgcagactg tgtttgatcc aggagagtcg
    20041 ctttaaacat ttcagcatcg gtttcgatct taatccgttc ttccacttta attctccctt
    20101 tacccatcat ctcgcctcct ttgttccatt ataaaatatc cgaatattcc gcaaatgaat
    20161 cttttggact atttttgacg aaatttgtcg caaccctttt gtagttttct aaacgatacg
    20221 catggcagca gcccgttatg cccagaatgt tttacaattc gaagacagct gatttacttg
    20281 catcagcact tcgggtatcc ttgttatgga aagatttttt tgcagaggag ctgacatgtt
    20341 tgcacatcat cgcacatcgc ggagcctcag cttacgcccc ggagaacacg tttgccgctt
    20401 ttgaaaaagc acgagagctg ggggccggct ttattgagct ggatgtacaa ttgacaaagg
    20461 atggaaagct tgcggttatt catgatgaca aagtggaccg gacgacaaac ggaacgggct
    20521 ttgttcggca ttttacaatg aaagagcttg aaacgcttga tgcaggaagc tggttcagcc
    20581 cttcctttca gggcgaaaaa attcccgatc ttgaagcggt tcttcacaag tatcacaata
    20641 aaatagggct gctcatcgaa atcaagtctt ccaaaacaca gcctggaatt gaaaaagcga
    20701 tcggccggct gattgaccgg ctcggccctt cggcgaacac gatcgtgcaa tcctttgacg
    20761 ccggagccat catgacgctt cataaccttt atccttcgat accaggcgcc gttttgatca
    20821 gaccgcggtt cggaatgctg ccgtacggcc gcctccggca tatttcttca tttgcacgct
    20881 atgtcagcct gaaacatacg atgctcagtt catttttgat caaatccgct cacagccatg
    20941 atatgaaggt ttttgcatgg acggttaacg gacgcaaaac cggacgccgc ctgcaaagct
    21001 ggaacataga cggaatcatt accgattatc cggattactt taagaaagaa ggaaaagcat
    21061 gaaatcatat ctagccgtat tcataggggg agcgctcggt tcactttgcc gctatgcgat
    21121 caacatgagt gcgggaagcg cttggttccc ttggccgacc tttatagaaa atgcatcagg
    21181 aagcctgctc ctcggtctgc tgacgggctt tttttcatcc agggcaaaaa aaccgctgat
    21241 ccaattatgt ttaggaacag gcttttgcgg aggttatacg acaatgtccg cgttttcaaa
    21301 agaaacggct ctgatcctcc agtccgcagc accccataac ggcgttttat atttggtggc
    21361 atcgcttgcc tccggaatct gccttgcttt tattggaatt gtgttaggga atcggatcgg
    21421 cggacaggca ggccaaaaaa aggagcgcta tacctcatga tgactgcggg ttttatgatt
    21481 gcggggggca tcggttcagt cctgagattt tggctcggca atatcatcgg ctccaaattc
    21541 aaaaatgcct gcattccggc aagcatttta atcattaaca ttctcggctc tttaatgctc
    21601 ggcatattcg tcagcctcga catccagcag cagatgctgt ccaccgtcat cggaaccggt
    21661 tttttcgggg gatttacaac cttctcaacc tttagtgttg aagccgttca gctcctggta
    21721 gaaaaacggc tgaaggcggg cgcggcctac atcatattga caatggcgtg ctgcgtcggc
    21781 ggtttttggg cggggagcct tgtttaatcg ttatacatac gatcaactgt tttgatgaag
    21841 caattgttct gatctggtta tgagcaggca aaatcgcgcc tgcttccggt tgttgttttt
    21901 tcctggcgct agccgggcgg atttataatg gtcgc
//
