LOCUS       NZ_CP021892            21612 bp    DNA     circular CON 23-JUN-2024
DEFINITION  Bacillus subtilis subsp. subtilis strain SRCM100333 chromosome,
            complete genome.
ACCESSION   NZ_CP021892
VERSION     NZ_CP021892.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis subsp. subtilis
  ORGANISM  Bacillus subtilis subsp. subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4086692)
  AUTHORS   Cho,S.H.
  TITLE     Genome sequence of Bacillus subtilis subsp. subtilis strain
            SRCM100333
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4086692)
  AUTHORS   Cho,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2017) Bioinformatics Research Institute, Microbial
            Institiue for Fermentation Industry, 61-27 Minsokmaeul-gil,
            Sunchan-eup, Sunchang-gun 56048, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 272.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002201995.1-RS_2024_06_23
            Annotation Date                   :: 06/23/2024 03:30:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,461
            CDSs (total)                      :: 4,339
            Genes (coding)                    :: 4,054
            CDSs (with protein)               :: 4,054
            Genes (RNA)                       :: 122
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 285
            CDSs (without protein)            :: 285
            Pseudo Genes (ambiguous residues) :: 0 of 285
            Pseudo Genes (frameshifted)       :: 188 of 285
            Pseudo Genes (incomplete)         :: 96 of 285
            Pseudo Genes (internal stop)      :: 52 of 285
            Pseudo Genes (multiple problems)  :: 44 of 285
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3694851
            Orig. end                         :: 3716463
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Microbial Institute for
            Fermentation Industry.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="8"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11612](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11612
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     gene            complement(31..1170)
                     /gene="acdA"
                     /locus_tag="S100333_RS19680"
                     /old_locus_tag="S100333_04013"
     CDS             complement(31..1170)
                     /EC_number="1.3.99.-"
                     /codon_start=1
                     /gene="acdA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391598.1"
                     /locus_tag="S100333_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04013"
                     /product="acyl-CoA dehydrogenase AcdA"
                     /protein_id="WP_014481201.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.2e-40, bitscore:
                     136.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.7e-26, bitscore:
                     89.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.8e-52, bitscore:
                     174.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFSLSEEHQMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREM
                     ANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFGTE
                     EQKTEYLTQLALGEKIGAFALTEARSGSDAGSMKTTAERIGDDYVLNGSKVFITNGGVA
                     DIYIVFAVTDPEKKKKGITAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPAS
                     KRLGQEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIGEQQGI
                     AFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEAVQIFGG
                     YGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD"
     gene            complement(1167..3284)
                     /gene="fadF"
                     /locus_tag="S100333_RS19685"
                     /old_locus_tag="S100333_04014"
     CDS             complement(1167..3284)
                     /codon_start=1
                     /gene="fadF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391599.1"
                     /locus_tag="S100333_RS19685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04014"
                     /product="heterodisulfide reductase-related iron-sulfur
                     binding cluster"
                     /protein_id="WP_088272547.1"
                     /transl_table=11
                     /translation="MSGFLIANTLLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQR
                     FKERLHDIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLPLG
                     PVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTVLLG
                     NGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVYVPQS
                     KHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYACVECG
                     RCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGNQLAAAS
                     AGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKIIDLRRYLV
                     LTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKKEGKEFEYL
                     FWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGNEFLFQELAE
                     KNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELVKNGKLKPQHP
                     LHETITFHDSCYLGRYNEVYDPPREILKGIPGVQLVEMERNRETGMCCGAGGGLMWMEE
                     ETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAMEAEDQVKTYDVVELLAQSV
                     LGADLKMGEKQ"
     gene            3438..4634
                     /gene="cls"
                     /locus_tag="S100333_RS19690"
                     /old_locus_tag="S100333_04015"
     CDS             3438..4634
                     /GO_function="GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cls"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391600.1"
                     /locus_tag="S100333_RS19690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04015"
                     /product="cardiolipin synthase"
                     /protein_id="WP_014481203.1"
                     /transl_table=11
                     /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSDI
                     ELIHCGADLVERMMKDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLLLD
                     WAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIGGFN
                     IAEEYLGKKAKFGNWEDYHLRMMGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQQGAI
                     SHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSVRIIVP
                     MKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANFDKRSLF
                     LNEEVNVEIDDEAFTSEVYATIEEDMKKSERLTMEDFSKRTFRQRPAEWLGRALSYFL"
     gene            4647..5609
                     /gene="uvsE"
                     /locus_tag="S100333_RS19695"
                     /old_locus_tag="S100333_04016"
     CDS             4647..5609
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0009650 - UV protection [Evidence IEA]"
                     /codon_start=1
                     /gene="uvsE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391601.1"
                     /locus_tag="S100333_RS19695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04016"
                     /product="UV DNA damage repair endonuclease UvsE"
                     /protein_id="WP_050258580.1"
                     /transl_table=11
                     /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVTK
                     ANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKTHQ
                     LRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGNKDT
                     ATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYANPDDH
                     ADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFRQWGTN
                     IDFMIEAKQKDKALLRLMDELSSIRGVKRLGGGALQWKS"
     gene            5690..5962
                     /locus_tag="S100333_RS19700"
     CDS             5690..5962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391602.1"
                     /locus_tag="S100333_RS19700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_003227597.1"
                     /transl_table=11
                     /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKIK
                     SLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL"
     misc_feature    complement(6054..6070)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.82"
                     /tool="antismash"
     gene            6224..>7099
                     /locus_tag="S100333_RS22940"
                     /old_locus_tag="S100333_04017"
                     /pseudo=""
     CDS             6224..>7099
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033551.1"
                     /locus_tag="S100333_RS22940"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04017"
                     /product="IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKPYYSENKDRPSLDPLILFKMMFIGYLYGIRSERQLEKEIYYNM
                     AYRWFLGLNINDPVPHHSTISWNRRTRFKDTTIFQDIFDEIVLQAINHDMVGGRVLFTD
                     STHLKANANKHKYTRKTIAQDTQNYIKDLNEAIQEDREEHGKKPLTAKEEVKAEKEIRH
                     STTDPESGYLYRENKPEGFFYLDHRTTDMKYNIITDAYVTPGNVHDSVPYLDRLDHQIA
                     RFGFQVEAVALDSGYLTAPICKGLSDRQIFGVIAHRRYHPIRGLFPKWKFHYDSEQDRY
                     ICPITKHLHTQ"
     gene            7069..7449
                     /locus_tag="S100333_RS22945"
                     /old_locus_tag="S100333_04018"
     CDS             7069..7449
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025126.4"
                     /locus_tag="S100333_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04018"
                     /product="transposase"
                     /protein_id="WP_237983620.1"
                     /transl_table=11
                     /translation="MSNHQTLTYSTTDRKGYRSYKSNPEICSSCPLLENCTKSKNRQKV
                     ITRHVWEDHKEKVRQNRLSVSGKNLYKKRKEKIERSFADSKQLHGLRYCRLRGKRNVSE
                     QVLLTAACQNMKKIATYLAKQG"
     gene            complement(7591..9261)
                     /gene="argS"
                     /locus_tag="S100333_RS19710"
                     /old_locus_tag="S100333_04020"
     CDS             complement(7591..9261)
                     /EC_number="6.1.1.19"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391614.1"
                     /locus_tag="S100333_RS19710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04020"
                     /product="arginine--tRNA ligase"
                     /protein_id="WP_088272548.1"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLEIPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRG
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     gene            complement(9258..9686)
                     /gene="ywiB"
                     /locus_tag="S100333_RS19715"
                     /old_locus_tag="S100333_04021"
     CDS             complement(9258..9686)
                     /codon_start=1
                     /gene="ywiB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391615.1"
                     /locus_tag="S100333_RS19715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04021"
                     /product="DUF1934 domain-containing protein"
                     /protein_id="WP_014481216.1"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVKGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     misc_feature    9893..9908
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            10001..10132
                     /gene="sboA"
                     /locus_tag="S100333_RS19720"
                     /old_locus_tag="S100333_04022"
     CDS             10001..10132
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="sboA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391616.1"
                     /locus_tag="S100333_RS19720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04022"
                     /product="subtilosin A"
                     /protein_id="WP_003222002.1"
                     /sec_met_domain="Subtilosin_A (E-value: 9.2e-29, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       10001..10030
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="S100333_RS19720_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       10031..10132
                     /prepeptide="core"
                     /locus_tag="S100333_RS19720_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[10000:10030](+)"
     gene            10089..10241
                     /gene="sboX"
                     /locus_tag="S100333_RS19725"
     CDS             10089..10241
                     /codon_start=1
                     /gene="sboX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054594.1"
                     /locus_tag="S100333_RS19725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin-like protein SboX"
                     /protein_id="WP_010886632.1"
                     /transl_table=11
                     /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIHT
                     QPFFI"
     gene            10266..11612
                     /gene="albA"
                     /locus_tag="S100333_RS19730"
                     /old_locus_tag="S100333_04023"
     CDS             10266..11612
                     /codon_start=1
                     /gene="albA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391617.1"
                     /locus_tag="S100333_RS19730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04023"
                     /product="subtilosin maturase AlbA"
                     /protein_id="WP_069837825.1"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1081.4, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 5.2e-29,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-07, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-44, bitscore:
                     150.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.4e-06, bitscore: 24.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-21, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.3e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-09, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRAIR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIIHPTKDAEQHRKFMEYEQNVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     aSDomain        10281..10556
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_S100333_RS19730_Subtilosin_rSAM_RRE.1
                     "
                     /evalue="3.40E-31"
                     /identifier="RREFam018.1"
                     /label="S100333_RS19730"
                     /locus_tag="S100333_RS19730"
                     /protein_end="97"
                     /protein_start="5"
                     /score="98.4"
                     /tool="antismash"
                     /translation="MFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLNKTAYE
                     LCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQ"
     gene            11625..11786
                     /gene="albB"
                     /locus_tag="S100333_RS19735"
                     /old_locus_tag="S100333_04024"
     CDS             11625..11786
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391618.1"
                     /locus_tag="S100333_RS19735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04024"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbB"
                     /protein_id="WP_003222006.1"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGM
                     RARKADSR"
     gene            11783..12502
                     /gene="albC"
                     /locus_tag="S100333_RS19740"
                     /old_locus_tag="S100333_04025"
     CDS             11783..12502
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="albC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391619.1"
                     /locus_tag="S100333_RS19740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04025"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014481218.1"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKTREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     gene            12495..13805
                     /gene="albD"
                     /locus_tag="S100333_RS19745"
                     /old_locus_tag="S100333_04026"
     CDS             12495..13805
                     /codon_start=1
                     /gene="albD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391620.1"
                     /locus_tag="S100333_RS19745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04026"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbD"
                     /protein_id="WP_088272549.1"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCLSAALMPAATLPLCAVHMLWAVVIDFPVFLQAPPQQSRMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAAFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRPIS
                     VLTFLQCIELLLAGAFIRLTADKKRPFFSWQTEQQLWSGFSKYRSYLFCLPLFLATLAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     gene            13795..14955
                     /gene="albE"
                     /locus_tag="S100333_RS19750"
                     /old_locus_tag="S100333_04027"
     CDS             13795..14955
                     /codon_start=1
                     /gene="albE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391621.1"
                     /locus_tag="S100333_RS19750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04027"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbE"
                     /protein_id="WP_088272619.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 5.5e-05,
                     bitscore: 21.2, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLK
                     EQIIDDFGCAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPS
                     SLSFEAVEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRKDRIKAIHP
                     KRFHDATDFIVDLASQQKQLNILGQVQACDVRGHAPQTSAVTSERIPVNRHVFETETRS
                     AAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYD
                     VMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQFDSPEGL
                     LAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     gene            14960..16240
                     /gene="albF"
                     /locus_tag="S100333_RS19755"
                     /old_locus_tag="S100333_04028"
     CDS             14960..16240
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="albF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391622.1"
                     /locus_tag="S100333_RS19755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04028"
                     /product="pitrilysin family protein"
                     /protein_id="WP_088272550.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.6e-13, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQTHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHTERKIIPACPPALSQKMMLGDEERMEDTWTGLQIGALPGQNDLLTIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQAAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIYISQKEAIRQ"
     gene            16237..16938
                     /gene="albG"
                     /locus_tag="S100333_RS19760"
                     /old_locus_tag="S100333_04029"
     CDS             16237..16938
                     /codon_start=1
                     /gene="albG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391623.1"
                     /locus_tag="S100333_RS19760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04029"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbG"
                     /protein_id="WP_088272551.1"
                     /transl_table=11
                     /translation="MKKNTVFTLLLLLIGMAAYSFGWVQAVAEAAAHYIQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDGYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFTISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     gene            complement(16944..18311)
                     /gene="ywhL"
                     /locus_tag="S100333_RS19765"
                     /old_locus_tag="S100333_04030"
     CDS             complement(16944..18311)
                     /codon_start=1
                     /gene="ywhL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017696256.1"
                     /locus_tag="S100333_RS19765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04030"
                     /product="YncE family protein"
                     /protein_id="WP_088272552.1"
                     /transl_table=11
                     /translation="MDLSALQENCFCFCDEEISREAPFQVPIDIPEGFKVDSAEASAAV
                     TWSTDNVSCISEPCLIQTGPETEDIGVRYAVRVQGTIMLLVSVSPVRNQYGQGDGAVSV
                     IHTEEIDQVVYYAAQSDRCPDFSQMTVEDLLIVPPFYGSPLTVAGTLVLPPSPDPQSYV
                     FTANTGDSTVSVIDADLNTVVKTILFSAVPTNLGVTFDKAFTYVLHGNTNLVSVIDNKT
                     LTIINTITVGGGPRKIEFDPTDEYAYVMAAGSIYMIDTANQSVIDVIAIPGALDFALDP
                     NGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLIATPYAGNFAYVLNGELWPKG
                     VTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTARQRI
                     IANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVKVISVGAGPSAIVM"
     misc_feature    18287..18304
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(18360..19711)
                     /gene="ywhK"
                     /locus_tag="S100333_RS19770"
                     /pseudo=""
     CDS             complement(18360..19711)
                     /codon_start=1
                     /gene="ywhK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391625.1"
                     /locus_tag="S100333_RS19770"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="YncE family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISNITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAIYVIGIDTLTVERSI"
     gene            complement(19708..19938)
                     /locus_tag="S100333_RS23120"
                     /pseudo=""
     CDS             complement(19708..19938)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009968328.1"
                     /locus_tag="S100333_RS23120"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQIPPFIILYMSYFIINILVRSAKKPQFFLSLHRMFGDIFSKRSF
                     YPQ"
     misc_feature    19892..19908
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            19941..21086
                     /gene="rapF"
                     /locus_tag="S100333_RS19780"
                     /old_locus_tag="S100333_04033"
     CDS             19941..21086
                     /codon_start=1
                     /gene="rapF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391626.1"
                     /locus_tag="S100333_RS19780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04033"
                     /product="response regulator aspartate phosphatase RapF"
                     /protein_id="WP_069837832.1"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAVSHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFT
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     gene            21070..21189
                     /gene="phrF"
                     /locus_tag="S100333_RS19785"
                     /old_locus_tag="S100333_04034"
     CDS             21070..21189
                     /codon_start=1
                     /gene="phrF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391627.1"
                     /locus_tag="S100333_RS19785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S100333_04034"
                     /product="phosphatase RapF inhibitor PhrF"
                     /protein_id="WP_009968329.1"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
ORIGIN
        1 aagagtgatc cgactgagag atgttttccg ttaatccgcg agcattctgg agatgaccag
       61 tctttgaatt tcttgagtgc cttcatagat ttgcgtgatt tttgcatcac gcatatagcg
      121 ttctaccgga taatcttttg tatagccgta gccgccgaaa atctgcacgg cttcggtcgt
      181 taccttcatc gccgtatccc cagccatcag tttggacata gcggaagctt ttccatatgg
      241 aaggcccgat gattctaacc acgcagcctg ataggtcaat agccttgaag cttctatcat
      301 tgtcgccata tccgcgagtt taaaagcgat gccctgctgc tcgccgatcg attttccgaa
      361 ttgctttcgc tcttttgcat attgaagcgc cgcatcaagc gctccttggg cgatgcctac
      421 ggcttgtgca gctatgccgt ttctgcctcc gtcaagcgtc ttcatcgcga ttttgaagcc
      481 ttctccttct tgtccgagac gctttgatgc gggcactaca caatcttcga acatgatttc
      541 cgttgtcggt gaagaacgga tgcccagctt cttttctttc ttgcctgtaa aaaatccttc
      601 aaaatccttt tctactataa aagcggtaat gccttttttc tttttctcgg gatcggtgac
      661 ggcaaaaaca atgtaaatat cagcaacgcc gccgtttgtg ataaacactt tggaaccatt
      721 taacacatag tcatcgccga ttcgttcagc agttgttttc atgctgccgg cgtcagatcc
      781 agaccgtgct tcggtcaatg cgaatgcgcc gattttctct ccgagggcca gttgtgttaa
      841 gtactctgtc ttctgttcct ccgtcccaaa ggcaaacagc ggccagctgc aaagagagat
      901 atgggctgaa agcgtcactc cggtggaggc gcacactttt gacagctcct ccaccgcgat
      961 gacgtaggcc aaatagtcac ttccgattcc gccgtaatct tcaggccatg gaattcccgt
     1021 cagccccaga tttgccattt cccgaaacag ctcgcgatcg aagcgttctt gttcgtcccg
     1081 ttctgccgca gtcggggcca cctcatgctt cgcaaaatcg cgcaccaatt ttcgtatcat
     1141 ctggtgttct tctgataatg aaaaattcat tgcttctccc ccattttcag atcagcgcct
     1201 aaaacggatt gagccagaag ctcgacgacg tcgtacgttt tgacttggtc ttcagcttcc
     1261 atcgcctttg tgccgtcccc aagcattgtg agacagtacg gacagccgga actgatcacc
     1321 gatgggttga ctgcgagcgc ttgctctgtc ctggcgacat taatcctgtt gcctgtttct
     1381 tcctccatcc acattaatcc cccgccagct ccgcagcaca tgccggtttc ccggtttctc
     1441 tccatttcaa caagctgcac gcccggaatg cctttcaaaa tctctctcgg cggatcatag
     1501 acttcattgt accggcccaa atagcatgaa tcatggaagg taatcgtctc atgaagcggg
     1561 tgctgcggct ttaattttcc gtttttcaca agctcggcca gcacttctgt atgatgataa
     1621 acctcgcctt caaatccgaa atccggatat tcgtttttaa ataaattgta tgcatgggga
     1681 tcgatcgtaa cgattttttt gacatcattt ttttcaaatt cagaaatatt cttctcagcc
     1741 agctcttgga acaaaaattc atttccgagg cggcgcggcg tgtctcctga atttttttct
     1801 ttattgccga ggatcgcgaa ggacacgccc gcgtgattga gcagcttggc aaaggaaatt
     1861 gcgattttct ggcttctgtt gtcgtaagac cccatggagc ctacccagaa aaggtactca
     1921 aattcttttc cttctttttt catttctttt acagtcggaa tctcagcatc cggcgcctca
     1981 tcacgccaat tttcacgttc cttgcggttg agtccccacg gattcccctg ccgctcaata
     2041 cttgtcattg cgcgctgggc gtcactgtcc atttttcctt ctgtcagtac gaggtagcgg
     2101 cggaggtcga tgattttatc cacgtgctca ttcatgaccg ggcattgatc ctcacagttt
     2161 cggcaagtgg tgcatgccca aatttcttcc tctgtgatga cgtcgccgat caagcttgga
     2221 ttgtaatcaa gcgccgctgc ggcttcctgc gatccgctgc ccgctgacgc cgcagccagc
     2281 tgattgcctc tcgtatgccg aaacgctgct gcgggcaccc atggggagcg cgaggtgacg
     2341 gcagcgcctt tttccgtgag atggtctctg agacgtaaaa tcaagtccat cggagacagc
     2401 atttttccgg tgcctgttgc agggcacata ttggtacagc ggccgcactc gacacacgcg
     2461 tacagatcaa gcagctgaga ctgcctgaaa tcctcaattt ttcccgctcc gtagctttct
     2521 ttcgtttcgt cggtaaaatc aattttttca agttttccgg cagattccat tctattgaaa
     2581 aagacgtttg ccgggccggc gattaaatgg gcatgcttag actgaggcac gtacactaaa
     2641 aagctaagca agaacagaag atggatccac catgcgatat agaaaatcac cgccgcacct
     2701 gttttcccga ctccgctaag cataaacgca atacctgagg caattggctc gctccaagaa
     2761 agcccatgct catgccaaat cagattcatc ccgttcccaa gcagaacggt cagcattaaa
     2821 cctccgataa aaatgagaac gagtccggct ttgaaaccgc gtttcagcct cacgagcttt
     2881 tcgatgtaac gtctgtagaa tgcccaccca acagcaatta aaatgagaaa cgtaacaatt
     2941 tcctgaaaaa aggtgaaggc gggatagacc gggccaagcg gcagattccg gccgggagcc
     3001 agtcctttaa tgataaagtc aattgctccg aactgaacca atataaatcc gtagaaaaac
     3061 atgacgtgaa tgattccgct tttcttgtcc ttgagcagtt ttttctgtcc gaatacattc
     3121 acccatatgt cgtgaagccg ttccttgaac cgttgatcaa attgttcttt ctggccgagc
     3181 ttgatgtagg ccagtctcgt tttgaccaaa tacacaaaca aatagacagc gtaagcggtt
     3241 acaatcagaa ataataatgt atttgcgatg agaaagccgc tcattccaat tccccctttt
     3301 tactgataaa gaccgcgatc ctctaccccg aatctgtata agattatctt tatgataaat
     3361 aatgaatgag tgttcagtca ataattaaat tcctgctgtt cgggcacact acctttacta
     3421 cggaaaggag tgccggtatg aaagtattta tcgtgattat gatcattgtc gttattttct
     3481 ttgccttgat tctgcttgat atcttcatgg gccgtgccgg atacagaaaa aaggcgtacg
     3541 agcctgtttt ttcaaaaaag aagagtgaca tcgaattgat ccactgcggc gctgatctcg
     3601 ttgagcggat gatgaaggat attcgccagg ccgcctcttc tgttcacatg atgtttttta
     3661 ttatgaaaaa tgatgaggtc agccacaata tgtatacctt gctgaaaaca aaagcccaag
     3721 ctggcgtatc cgtttatttg cttctggatt gggcgggctg ccgggcaatt aaaaaaacgg
     3781 cgctgcagac gatgaaaaat gccggcgtcc atgtccatgt gatgaatcgt ccccgttttc
     3841 cttttttctt ttttcacatg caaaaacgga atcaccggaa gattacggtg atagacggaa
     3901 aaatcggtta tatcggcggg tttaacatcg ccgaagaata tcttggaaag aaggcgaagt
     3961 tcggcaattg ggaggattat catctgcgca tgatgggaga aggcgtacat gatcttcaaa
     4021 cgctttttgc ttctgatcta aaacgaaata ccggaatcga actgggttcg gatgtttggc
     4081 caaagcttca gcaaggggct atttctcaca agatatatgc gaccgacggt tattcccttg
     4141 aaaacatata cttggccaac attgcacaag cgaagaatcg ccttacggtt tgcacgcctt
     4201 attacattcc atcaaaaccg cttcaagagg cccttattaa tgcaagaaaa aacggcgtat
     4261 ccgtgagaat cattgtaccg atgaaatcag accatccgct ggtacgagaa gcagctttta
     4321 cgtattattc ggagctcttg gatgccggct gtcttattta tcgttattat caaggatttt
     4381 atcatgtaaa agccctcatc atagacgacc atctcagcat tatcggaaca gccaacttcg
     4441 ataaacgaag cctgttttta aatgaagagg tgaatgtcga aattgatgac gaagcgttta
     4501 caagtgaagt ctatgccacg attgaggagg atatgaaaaa gtcggagcgg ctgacgatgg
     4561 aggatttcag caagcgcaca ttcaggcagc gcccggcgga atggctcggc agggcattat
     4621 cttatttctt ataaaggaga gttcctatga ttttcagatt cgggttcgtt tcaaatgcga
     4681 tgagcctttg ggatgcgtct cccgctaaaa cattgacatt cgcgcgttat tcaaagcttt
     4741 caaagactga aagaaaagaa gcgcttctga ctgtgacaaa agccaatttg cgtaatacga
     4801 tgagaaccct tcactatatc atcggacacg gcatcccttt gtaccgtttt tccagttcga
     4861 ttgtgccgct ggctacgcat cccgacgtga tgtgggattt tgtaacaccg tttcaaaaag
     4921 agtttcggga gattggagag cttgttaaaa cccatcaact gcgaacaagc tttcatccaa
     4981 atcaattcac tctgtttacg agcccgaagg aatccgtcac aaaaaatgcg gtaaccgata
     5041 tggcgtatca ctaccgcatg cttgaagcca tgggcattgc tgatcgctcc gttatcaaca
     5101 ttcatattgg cggcgcttac ggaaataaag acaccgccac tgcacaattt catcaaaata
     5161 taaaacagct gccgcaggag atcaaagagc ggatgacact tgaaaatgat gataaaacat
     5221 atacaacgga agaaacgctt caggtctgtg agcaggagga tgttccgttt gtctttgact
     5281 ttcatcattt ttacgccaat ccagacgatc acgccgacct gaatgtagca ctgccccgca
     5341 tgatcaaaac gtgggagcgg atcggccttc agccaaaggt tcacttgtct tccccaaaat
     5401 cggaacaagc gatacgcagc catgccgatt atgttgacgc caactttttg ctgccgctgt
     5461 tggaacgctt taggcaatgg ggaacgaata ttgatttcat gattgaagca aagcagaaag
     5521 acaaggcgct tctccgcttg atggatgaat taagctccat ccgcggtgtc aaacgcctcg
     5581 ggggcggtgc gctgcaatgg aaatcataaa tgtgcaaaaa taggtttacg acttgtcagc
     5641 tttgggaact taggctatat aagacaacaa tcgatggagg agaaagatca ttaaaaatat
     5701 caagtctctg aaagtagccg cacaggcctt tactttaaga aatttgattc atctttataa
     5761 aatgtgccat tccggaagcc acgaggttta tatttattca aagaaaacga tgtgcaaaat
     5821 caaaagctta attgagcttg aaacattccg catggctcat aatgaaaagg aatatttgat
     5881 cgtagttgaa ggaacaaaag catcacagct cattgaaaaa ttccaaaatc tcatcgagcc
     5941 tgctgagaga gaagcgctct aacttacata caaaaaagga tagacatctg tctatcctca
     6001 ggctgtcgag aaaatctcga cagcctttat ttttccttaa aatatccatt cttctgtaat
     6061 aaaataaaag aaagacttaa aaggacggtg tctttctcat gttccacaca agaaactctt
     6121 ctcaaaacac agccgaattt gttctgcttg accaactcgt tgaagaggat cacctgcttc
     6181 ggaaaattga taaacacata gactctcttt catcattgaa aaggtgaaac cttactacag
     6241 tgaaaacaaa gaccgcccct cacttgatcc gcttatttta tttaaaatga tgtttatcgg
     6301 atacctctat ggtatccgtt cagaaagaca gcttgaaaaa gaaatttact acaatatggc
     6361 gtacagatgg tttctcggat tgaacataaa cgacccggtt ccacaccact ccaccatcag
     6421 ctggaacaga cgcacacgct ttaaagatac aaccatcttc caagacattt ttgatgagat
     6481 cgttcttcag gccatcaatc atgacatggt gggcggacga gtcctattca ccgactccac
     6541 acaccttaaa gccaatgcca acaagcataa atacacaaga aaaacaattg cgcaggatac
     6601 ccaaaactat atcaaggatt taaatgaagc cattcaagag gatcgggagg aacacggaaa
     6661 aaagccatta acagccaagg aggaagtgaa agctgaaaaa gagatccgcc acagtacaac
     6721 cgatccggaa agtggctatc tgtatcgtga aaacaaacca gaaggttttt tctatttaga
     6781 tcaccgcaca acagatatga aatacaacat tatcaccgat gcctacgtca cacctggaaa
     6841 tgtccatgat tctgtgcctt atcttgaccg attagaccac caaatcgcac gatttggttt
     6901 tcaagtagaa gccgtcgccc ttgattccgg atatttaacg gctccgatct gtaaaggatt
     6961 atctgaccgc caaatctttg gtgtcatcgc acatagacgt tatcacccta tccgaggatt
     7021 gtttccaaaa tggaaatttc attatgacag tgaacaagac agatacattt gtccaatcac
     7081 caaacactta catactcaac aactgaccga aaaggctacc ggtcatacaa atcaaatcct
     7141 gaaatatgtt cctcatgccc gctgcttgaa aactgtacaa aatcaaagaa tcggcagaaa
     7201 gtgattactc gacatgtatg ggaagatcat aaagaaaagg tcagacaaaa tcgcttgtct
     7261 gtttcaggaa aaaacctcta caaaaaaaga aaagaaaaaa tagagcgaag ctttgcagat
     7321 tcaaaacaac tgcatgggct tcgctattgc aggttgaggg gaaaacgaaa tgtgagtgaa
     7381 caagttctcc tcacagccgc atgccagaac atgaagaaga ttgccacata cctagccaag
     7441 cagggctagg catgtgggag cgctttttct gcatctgaaa cctgatgaat atctaaagaa
     7501 actgtataaa acaaaaaagc ttgtagaaaa aacgtcgttt tctctacaag ctaaggacaa
     7561 agtccgaaga ctttgtcctt ttgttcgtga ttacattttt tccggagccg atacgccgat
     7621 cagctgaagc gcattgttca gcgtaatttg cgttgccttc attaaagcca ggcgcgcgcg
     7681 gcttttctct tcattttcag ggtcgatgac tttctctgcg ttgtagaagc tgtgcagagc
     7741 agaagccaga tcataaatat agttagtgac acggtgcgga attcgttttt ccgctgcttc
     7801 cgccactgcc tctgggaagc cgccgatcgt tttcagcaga tcgtattctt tttctgattg
     7861 aatatggctg aaatcaagat ctgccgccgg tttaagcccc tgctcttccc cttggcgaag
     7921 catgctgcaa atacgtgcat gcgcgtattg tgcataatac acagggtttt cgttagatgt
     7981 tgatacagca agatctaagt caaaatccat atgggtgtct gcacttcgca ttgcaaagaa
     8041 gtaacgcacg gcatccaagc cgacttcttc aatcaggtca cgcatcgtta cggctttacc
     8101 ggtccgtttg ctcattttca ttttctcgcc gtttttgtaa aggtgaacga gctgaatgat
     8161 ttctacttca agcgttcctt tttcataccc cagcgcttcg attgccgctt tcatacgcgg
     8221 gatgtagccg tggtgatcgg cgccccaaac gttgatcagc ttatcaaagc cgcggtcaag
     8281 cttgtcctta tgatacgcga tatcaggaag caggtacgtg tacgtgccgt ccttcttgat
     8341 caatacgcgg tctttatcat cgccaaacgt cgtggaacgg aaccaagtcg cgccgtcttc
     8401 ttcatagaca tggccttttc cgcggagcgc ttcaagcgcc ttgtcgattt ttccattttg
     8461 gtacagtgaa gtttctgaat accacacatc aaacggcaca cggaagtttt ccaagtcctt
     8521 gcgaagcttt tccagctcgt atttcaggcc gtattcacgg aaaaacgcga ggcgttcact
     8581 ttcctcttcg ttaacgaaac ggtcaccgta ttcctcagcg agacgctttc cgatcgcaat
     8641 gatatcctcg ccgcggtagc catcctccgg catcggtttt tccaatccga gtgcttcgaa
     8701 gtaacggact tcaacagaga gcgccagatt gttgatttgg tttcccgcat cgttaatgta
     8761 gtattcgcgg cttacatcgt aacccgcttt tgaaagcacg ttgcacaagg aatcgccgac
     8821 agccgccccg cgcgcatgcc cgaggtgaag gtctcccgtc ggattcgctg atacgaattc
     8881 tacctgaact cgttcaccgt ttccgatgtt cgtttccccg tatgcttccc ctgcttccag
     8941 tacagacgga atcagctttg ttaaatattg attgttcata tagaaattga taaaacccgg
     9001 gccggcgata tccagttttt caatcgaagc ctttccttta tcaaaatggg cgacaatctc
     9061 ttcagcgatt tggcgcggcg ctttttttgc cactcttgcc agctgcatcg ccatattcgt
     9121 tgagtagtcg ccgtgtgttt tatctttcgg tatttctaaa acaacattgg gaatctggct
     9181 ttcttcagcc agtcccgctt tcagaacggc cgctttgatt tcttctttca gcacgtcctt
     9241 catttgttcc gcaatgttca tgcgtgagtt cctccctcat acgtgatcgt catattatgt
     9301 aaatgctcct gctcgtctcc gacatgcatg tcatatgcga tgctgatacg gcctttttct
     9361 tcatcgagat cagattgaat cgattttgtg cttgttttca gctcaagctc accaaatgac
     9421 attttatatt tagcaattgt ggaagctccc tttacgaaac gctgattcat tttgacagcg
     9481 cctgacctca tgaccaggac ttcgccttcg cttactttca caatcgtttt gactttgcct
     9541 aagtcgtgtt cttcataata agatagatac actttatttt gttttacata gtaaaatccg
     9601 gtggtgcgga attcgatgac ttcttggttt ccgtcatcct cgatcacaga cttcacatgg
     9661 agtgttatcg gtgtctcttg cttcattctg acacgtcctt ttcatcattc cactttgact
     9721 tgaatagtat aatcattcgg tttgtaaact tcaactgctt ctatcttacc atcattgctc
     9781 atcagatttg aagataaacc tcataaaaag catttcctta tatagaagag aaaatcatat
     9841 cactaattac ctttagtaaa tgttacattt ttccgaaatc tatcatttcc ttttcacatt
     9901 tttttcaaaa tatatgtatt gaattagtaa tttgatagtt ttaagataaa agtacaacat
     9961 agatctgtta gaaaaacaaa aaaaaaggga ggattcaatt atgaaaaaag ctgtcattgt
    10021 agaaaacaaa ggttgtgcaa catgctcgat cggagccgct tgtctagtgg acggtcctat
    10081 ccctgatttt gaaattgccg gtgcaacagg tctattcggt ctatgggggt aaggatctcc
    10141 caaaagggca tagtcattct actatgccct ttttaagtaa attacaattt ttaactaaaa
    10201 tctacctctt ggatatacat acacaaccgt ttttcatttg aatcatatgt ataggggatg
    10261 gtattttgtt tatagagcag atgtttccat ttattaatga aagtgtaaga gttcaccagc
    10321 ttcctgaggg cggcgtgtta gaaatcgact acttgcgcga taatgtctcc atttctgact
    10381 ttgagtattt ggatctcaac aaaacagctt acgagctctg catgcgcatg gatggccaaa
    10441 aaacagctga gcagatttta gctgagcaat gtgcagtgta tgatgaatca ccggaagacc
    10501 ataaagattg gtattacgac atgctcaaca tgctccagaa caagcaggtt atccagcttg
    10561 gaaaccgggc catccgccat accatcacca cgagcggaag caatgaattt ccgatgcccc
    10621 tgcacgccac ctttgaactg acgcaccgct gtaatttgaa atgcgcccac tgttatttgg
    10681 aaagctcgcc tgaagcgctc ggcaccgtgt cgattgagca attcaaaaaa acggctgata
    10741 tgctgtttga taacggtgta ttgacatgcg aaatcacagg cggagaaatt tttgtccatc
    10801 caaacgccaa tgagattctt gactatgtgt gtaaaaagtt caaaaaagtc gctgtcttaa
    10861 caaacggaac actcatgcga aaagagagcc tggagctttt gaagacttac aagcaaaaaa
    10921 tcatcgtcgg catttctctt gatagtgtca attccgaggt ccatgactcc tttagaggga
    10981 gaaaaggctc ttttgcccaa acttgtaaaa cgataaaatt gttgagtgac cacggtatat
    11041 ttgtcagagt cgccatgtct gtcttcgaaa aaaacatgtg ggaaatccac gatatggccc
    11101 aaaaggttcg ggatctcgga gcgaaggcgt tttcttacaa ttgggttgac gatttcggaa
    11161 gaggcaggga tattatccat ccaacgaaag acgccgagca gcaccgcaag tttatggaat
    11221 acgagcaaaa tgtgattgat gagtttaaag atctgattcc gattattccc tatgagagaa
    11281 aacgcgcggc aaattgcggc gctggctgga agtccattgt gatcagcccg ttcggcgaag
    11341 tacgtccttg cgccctcttt ccaaaggaat tttcattggg aaatattttt catgattcct
    11401 atgaaagcat ctttaactcc cctctcgtcc ataaactgtg gcaagcgcag gcgccgcggt
    11461 tcagcgaaca ttgcatgaaa gacaaatgcc cgttcagcgg ctattgcgga ggctgttact
    11521 taaaagggct gaactctaac aaatatcacc gaaaaaacat ttgctcttgg gcgaaaaatg
    11581 aacaattaga agacgtggtc cagcttattt aggagggaaa cgatttgtca ccagcacaaa
    11641 gaagaatttt actgtatatc ctttcattta tctttgtcat cggcgcagtc gtctattttg
    11701 tcaaaagcga ttatctgttt acgctgattt tcattgccat tgccattctg ttcggaatgc
    11761 gcgcgcggaa ggctgactcg cgatgagcat tttggatata cacgatgtat ccgtttggta
    11821 tgaacgggac aacgtcatct tagaacaagt ggatttacat ttagaaaaag gcgccgttta
    11881 cgggctgctt ggggtaaacg gcgccggaaa aacgacactg attaatacgc tgacaggcgt
    11941 gaaccgcaat ttcagcgggc gctttacact gtgcggaatt gaagcggagg ccggcatgcc
    12001 gcagaaaaca tcagatcagc tgaagactca ccgttacttc gccgccgatt atccgctgct
    12061 atttacagaa attacggcga aggactatgt gtctttcgtc cattcgcttt atcaaaagga
    12121 tttttcagag cagcagtttg ccagtttggc cgaggccttt catttttcga aatacatcaa
    12181 caggagaatt tcggagctgt ccttggggaa caggcaaaag gttgtattga tgacaggctt
    12241 attgctgcgc gctcccctat ttattttgga tgagccgctc gtcggtttgg atgtggaatc
    12301 gatagaggtt ttttatcaga aaacgcgcga gtactgtgaa gcaggcggga ccattttgtt
    12361 ttcttctcat ctgctcgatg tcgtgcaaag attttgtgat tacgcggcca ttcttcacaa
    12421 caaacagatc caaaaggtca ttccgattgg agaggagacc gatctgcggc gggaattttt
    12481 cgaggtgatc ggccatgaat aacataatcc ccatcatgtc tttgctgttc aaacagcttt
    12541 acagccggca agggaaaaag gacgccatcc gcattgccgc aggccttgtc attctggccg
    12601 tatttgaaat cgggctgatc cgccaggccg gcattgatga atcggtgttg cgcaaaacgt
    12661 atatcatact cgcgcttctc ttaatgaacg catatatggt gtttctttct gtgacatctc
    12721 aatggaagga atcttatatg aaactgagct gcctgctgcc gatttcttca cggagctttt
    12781 ggctcgccca gagtgtcgtt ttgtttgtcg atacctgttt gagaagaacg ttattctttt
    12841 ttattttacc gctgttctta tttggaaacg gaacgctgtc aggggcgcaa acattgtttt
    12901 ggctcggcag gttttcgttt tttaccgttt actccattat tttcggagtt gtgctaagca
    12961 accacttcgt caaaaagaag aacttgatgt ttctgctgca tgcggcgata ttcgcctgtg
    13021 tatgtctcag cgccgctttg atgccggccg ccacgcttcc gctttgcgcg gtgcatatgc
    13081 tgtgggcggt ggtcattgac tttcctgtct ttctgcaggc gcctccgcag cagagcagga
    13141 tgcattcatt tatgcggcga tctgagtttt cgttttacaa aagagaatgg aaccgattta
    13201 tctcttctaa agcgatgctg ttaaattacg cggtaatggc ggcgttcagc ggcttctttt
    13261 cgttccagat gatgaatacc ggcatcttca atcagcaagt gatttatatc gtgatttccg
    13321 cgcttctgct catctgctcg ccgatcgccc ttttgtactc gattgaaaaa aatgaccgca
    13381 tgctgctcat cacgcttccg atcaagcgga aaacgatgtt ttgggcgaaa tatcgctttt
    13441 attcaggcct attggcaggc ggatttctcc ttgtcgtgat gattgtgggt ttcatcagcg
    13501 gccgtccgat ttcagttctc acttttttgc agtgcattga gttgctgctg gcgggagctt
    13561 ttatcaggtt aactgcggat aaaaaaaggc ccttcttcag ctggcagacg gagcagcagc
    13621 tatggagcgg tttctcaaaa tatcggtctt atctgttttg tcttccccta ttcttagcca
    13681 cattagccgg caccgctgta tccttggcgg tcattccgat agccggtctg gtcatagtct
    13741 attacctgca aaaacaggat ggtggtttct ttgatacaag caaaagagaa cggcttggaa
    13801 gttaacctgc tgaagactca tcaattttca actatatcaa tcgccgcgag ctttctgaaa
    13861 ccgatcgaaa gcgcggcgga acctgaggaa gaaacgattt atttttacgg cgccgccgca
    13921 tacctgaagg agcaaatcat tgacgatttc ggttgtgctg ccggcagccg tttcatgtac
    13981 tcagcgaatc tcttttttga tcagcagctg aaaacctgcg ggacccgttt gattcaccca
    14041 ttatataacg ggaatcttca tgttgacgcc ctgatgaaaa cttttgcaga cttgtctttc
    14101 ccttcttctc tttcattcga agcagttgaa aaggccagga atgagctgct gctgaaaatc
    14161 gaaaagaaat tcactgatcc cttctcctac tcggcggcgc gcttggctga ggaggtcttc
    14221 ggaaacccga tgtacggcac aggcatgttt ggccggaaag acaggataaa ggcgattcat
    14281 cctaaacggt ttcacgacgc aacggacttt atcgttgatt tagcgtccca gcaaaaacag
    14341 ctgaacatat tgggacaagt acaagcatgt gatgttcggg gacatgcccc gcaaacgtcc
    14401 gctgtaacgt ccgaaagaat acccgtaaac cggcatgttt ttgaaacaga gacacgcagc
    14461 gctgcaggtc cttccgtctt gacactcgga tttgactgcg gagagatgaa agatgccagt
    14521 gattatatca aaatacagct aatagacgga ttactgggaa agtacggcca ttccgcttta
    14581 ttcaagcact tcagagagaa agatctggca gtctatcacg ttatcacccg ttacgatgtc
    14641 atgaacaatt tgctgcttgt ttcaatatgt acagatcagc ttcatgagat agacattccc
    14701 ccgcgcgttt tggaagctgt ctcagctttt catacagatg agcgggaact agaacaggca
    14761 aagcagtttt tacgcaatga attgctgctg caattcgatt ctcccgaagg tctattggcc
    14821 tatatgggga tcctgcgccg cttctcctgc acgaaagaag ccttgctgga tggcatctca
    14881 gcggttacat gccgtgatgt attgcaattc atagcgacca tcaattatat cggagctcat
    14941 gtagtaaggg gatgaaaaga tggaaaagaa agcctttttt caacagctgg atgaacgaac
    15001 cgatatcaga tacacagaca gcggactaaa aatattcaga ttgaaattcc cccgcgccca
    15061 cctgcggctg tgcaatgtaa aaatcgattt tggaagccgg gatgtatgta tacgggcaga
    15121 atccggtgat acactgcttc cgtatggcac agcgcatttt ttagagcatc ttctcttctg
    15181 gcataacggc cgcaatctgt acagtgattt ttttgcgcat ggcgcgcttt taaacgcatt
    15241 cactacctac accgatacca atttcatgtt tacctcatta ccggatcggc tcagacaaac
    15301 gatccccatc ctgcttgatg ctttatggaa ccactcattt gacaagaaga ttgtcgctca
    15361 ggaaaaagct gtgattacaa gcgaaattca aacagcacac cttaaccatc agctctcata
    15421 tcattatcag ctgatcagca tgctttctcc ctcctcacca gctgccgttt tccccgcagg
    15481 cagaatcgaa gatattgagg cgcttgacat cagtgattta caaaaagcct ataaggctgc
    15541 ctaccaaacc catcggatga cgctgttttt gattgggggc tcagaaaata cagaaacgct
    15601 tttgcctcct cacctccagc tggaaaagcg tccagattat catactgaaa gaaaaatcat
    15661 cccggcatgc cctccagccc tctcacaaaa aatgatgctg ggtgatgagg agcggatgga
    15721 agatacatgg accggattac agatcggcgc acttcccggg caaaacgatc tgttgacgat
    15781 caaactttat tgggatatcg cggctcgtat tctatttcaa ttagattcac cgttttttca
    15841 agagattcag caaacgtacc gcctggaaat cgatcgtttg tcagccgaga cttatatcta
    15901 tgaggatggc ggtttcttga tccttcacag tcaagggacc cattcttcag cttatatcga
    15961 tgtggcttca tactatgtca cacagaagaa agaacaggct gccgcctggc ttcaatacgg
    16021 caaggactct ttgacagacg cgatcattta tgacagcgat tatgtgcgta aatgcttcga
    16081 gtgggcagcc gagtgtgaca ggtgcgattg ctcgtttctt gacatgtacc acatcattca
    16141 agatatggat gcgcaggttt tcttgtctct cattgatgca atggcatctt ctaacaaagc
    16201 gatcatttac atttctcaga aagaggcgat cagacaatga aaaaaaacac tgtctttacc
    16261 cttttattgc tgcttatagg tatggcggct tattccttcg gctgggttca ggccgttgcc
    16321 gaagccgccg cccactatat acagatgatc aacaatgatg ctgtacggct cggactgctg
    16381 gcttgtaccg ctgccctcct gatgctgcct gcttttctct atcttcacta tgtcacccaa
    16441 tctgtgaaaa acatgacagc agcttttcag aaactcacac agtctcatca aagctgctgt
    16501 gactttcagc aacacaactt gtgcagccga tatgcagaag acgtcaaatc gctgcgtgac
    16561 ggctataaaa acgtccgcca aacatacgtg atggctgccg tgttgtgcca agtcatcata
    16621 ttcggctgca tgttcgaaat cgttaaagcc gtccctttcc gccttcacac gccccctgcc
    16681 ctttcaatgg gacttgcgat gctactgatc ctgtatttat tgttttgcat gcgaacgtat
    16741 ttgcggcagc ttttccggca cggcagcctg ttcagaaaag tgtttgcggg agcgctggca
    16801 gcagccggga tttggtggat gctcagtttc actataagtg aactgctgtt tctgattatc
    16861 ctggctgcca tccagcaaat cggatcattt atttataagc gattctctta tcgcagcacc
    16921 gcttctcttg atctataaaa tagctacatc acaatcgcag acgggcccgc gccaaccgaa
    16981 atcaccttca cggctgtata atcacttgtg cggtacacgg tcacagcatt gtcgttgggc
    17041 tgtgccgcat aaatatactg tttgtccggc gttacggcga ggtcaaaagc gccggggaga
    17101 gacacgtttg caatgatcct ctgtctggcc gtattaacta catataagtt attaataaga
    17161 aacggttcac tatatggctc tagaaaataa gctctagtgc tatcgagaga aaatacaatc
    17221 gtcctcagcg tttcaaataa acggctgaag tcccctcccc tgcttaatgg agacaaacta
    17281 atctccgtta cacctttcgg ccacagctca ccattcaaca cgtacgcaaa atttccagcg
    17341 taaggagttg caattaaact gggaaattca aatgtatcta tgatactttc taccaactgc
    17401 ccagtattta catcatattt atcaaccgac caactgcttc cattagcggt atagacatac
    17461 tgtccattcg gatcaagagc aaagtctaaa gcgccgggta tcgcgattac atcaattact
    17521 gattgattgg ccgtgtcaat catatatata gatccggcgg ccatcacgta ggcgtactca
    17581 tctgttggat caaattcgat ctttctcggt cctcctccaa cagtaatggt atttatgatg
    17641 gttaatgttt tattatcaat cactgagaca aggttggtat tcccatggag gacatacgtg
    17701 aatgctttat cgaaagtaac gcctagatta gttggcacag cagaaaacag gattgttttt
    17761 acaacagtgt ttaaatctgc atcaatgacc gaaaccgtgc tgtctccagt attggcagta
    17821 aacacatacg attgagggtc tggcgatggc ggcaaaacaa gtgtcccggc caccgtgagc
    17881 ggactgccgt agaaaggcgg cacgatgaga agatcttcca ctgtcatctg actaaaatca
    17941 ggacagcggt cagactgtgc tgcataataa acaacttgat caatctcttc agtatgaatc
    18001 acagaaaccg ccccgtctcc ttgtccatat tgatttcgca caggcgacac actgacaaga
    18061 agcataatgg tcccttgtac tctcacagca tatcgaacac caatatcttc tgtttccggc
    18121 ccagtctgga ttaagcaagg ctcactgata caggacacat tgtctgtact ccatgtaaca
    18181 gccgctgacg cttcggccga atcaaccttg aagccctcag ggatatctat cggcacttga
    18241 aacggcgctt ctcggctaat ttcctcatca caaaaacaga aacaattttc ctgtaaagca
    18301 gaaagatcca ttctttttca tgatttcacg tccttttaga aatgcacaac atgcagcggt
    18361 taaatcgtaa tggcacccgg tgaaacccca agagatatca cagtttcctc agaataatca
    18421 tctgtgttgt aaacaatgat gctctgctct ataaaacgag ttgcatacag aaaatcgcca
    18481 ttcggggtaa acgcatagtc tgttgctgat tgcggaagat ttccaattac acctgctcca
    18541 ttcggactga cagaatataa attgccagtg aagctgtcat gtaaatacac ctctgatcca
    18601 ctcgtaaaca ttacatatag cccgtcaggc tccagctctt gggtatccct gatcgtaaac
    18661 gtatttaaat caataaccgt caaataattg aataagaatt cttgttctaa tacatacgca
    18721 taccgctccg tagaatctgt ttctatggat gatacgataa gctctcgttc aatcgttcct
    18781 gtgacttcac cggtagttag gtccactttt tgcactatac caaaatttag aacataggcg
    18841 aataacccat tggggtcaat tgcaatatca aaaccttcta tatagacctc tcaacagtca
    18901 acgtatcaat tccaatcaca taaatggcag taccggtgaa aacataagca aactcatgat
    18961 tagggataaa tctaatcaat cgaggcggct gatccagcaa tatagttgct gtcactgtta
    19021 atgtgtcata atcgatgaca gaaatcacat tattgttggg atgtaagaca aacacagcgc
    19081 ttttatctgg cgtaatttca atacctgccg gattgtacgg aagagcaatc gttgtcacaa
    19141 cagtatgggt gtttgtatca atcacagaaa ctgattgatc atttggattc gctgtaaacg
    19201 cgtagacggg ttccggctcc ggtacaagca caatcgtccc cgtcaccgat aaaggactgc
    19261 cgtaaaacgg cggaacaaca acaaggttct caatcgtgat gttactgata tccgggcaat
    19321 catccggttc atcggaataa tagacgactt gatcgatttc tgcattgtga atgacggaaa
    19381 cagccccatc cccttgtcca tattgatttc gcacaggtga gacactgacg agcagcgtaa
    19441 cggttccctg cagacgcact gcaaattgaa caccgacctc atcaggctct ggccccgttt
    19501 gaattaagca acggtcactg acacaagaaa ggctgtctgc attccacgtc acgtttgcaa
    19561 cagcttcagc cggatcaacg acaaatcctt caggtaattc aatcggcgct tgaaacatgg
    19621 cttctcggct tgcttctccc tcacaaaaac ataagcactc ttcttgttct gctcctgctt
    19681 tttctttaaa ggaaagcttg ttttttctca ttccttcact tccttttcag acatacactg
    19741 ctcacgcaga tataacagaa tatggaagag taacgtgttt gcttgtacaa attactgagg
    19801 gtaaaagctt ctttttgaaa atatatctcc aaacatgcgg tgtaacgaaa gaaaaaattg
    19861 cggttttttt gcgcttctca caagaatgtt gatgataaaa tatgacatat atagaattat
    19921 gaagggaggg atttgcaaac gtgacaggtg tcatatcttc ttcttccatc ggagaaaaga
    19981 ttaacgaatg gtatatgtac atacgccgat tcagcatacc cgatgcagaa tatttgcgac
    20041 gagaaatcaa gcaagagctg gatcaaatgg aagaagatca agaccttcat ttgtactatt
    20101 cactgatgga gtttcggcac aacctgatgc ttgagtacct tgaaccgtta gaaaaaatga
    20161 ggattgagga acagccgaga ctgtctgatc tgctgcttga gattgataaa aaacaggctc
    20221 gtttaacagg tctgcttgag tactatttta atttcttcag aggcatgtat gagctggatc
    20281 agcgggaata tctgtcggct attaaatttt tcaaaaaggc cgaaagcaag ctgatattcg
    20341 ttaaggatcg gatagagaaa gctgagtttt tctttaagat gtctgaatct tattactata
    20401 tgaaacaaac gtatttttca atggactatg cacggcaagc atatgaaata tacaaagaaa
    20461 atgaagctta taatataaga ttgctgcagt gtcattcttt atttgccacc aattttttag
    20521 atttaaaaca gtatgaggat gccgtctcac attttcaaaa agcttattct atggcagaag
    20581 ctgaaaagca gccccaatta atgggaagaa ctttgtacaa tatcgggctt tgtaaaaaca
    20641 gccaaagcca atatgaggat gccataacat atttcaaaag agcaatagct gtttttgaag
    20701 aatcaaatat tcttccttcc ttacctcaag cgtatttttt aattacacag atccattata
    20761 aattaggaaa aatggataaa gctcatgaat atcatagtaa gggaatggct tattcacaaa
    20821 aggccggaga tgtaatatat ttatcagagt ttgaattttt gaaatcttta tacttatcag
    20881 gcccggatga agaagcaatt caaggatttt ttgattttct cgaaagtaaa atgttgtatg
    20941 ctgatcttga agatttcact attgatgtgg caaaatatta tcatgaacgt aaaaattttc
    21001 aaaaagcttc tgcttatttt ttgaaggtgg aacaagtaag gcaacttatt caaggaggag
    21061 tgagtttgta tgaaattgaa gtctaaacta ttactctctt gtctggctct aagcactgtg
    21121 ttcgtggcaa caactattgc aaatgcacct acacaccaaa ttgaagttgc acaacgagga
    21181 atgatttaac cgccgtccat cggcggtttt tttgtcccct ctttacccag tctcccaatc
    21241 cattctatga ttttttcaat aatcttaaaa atagtggaaa tgcagcatgt ctctaaaaag
    21301 tgtgagaacc cactttactc aatggaatcg agaaaatgat gtgacggagt tcgaaacgtc
    21361 gagtgcgaca gttgaacagg cagctgagac aatcggcgta agcctgtcta gaatcgccaa
    21421 gtccctgtcc ttcagagggg aaggagatca ggtgattctg attgtggcag ccggcgatgc
    21481 caagatcgac aacaaaaagt ccaggcaaac atttggcttt aaagcaagaa tgctctctcc
    21541 taatgaggta ctggagcaga caggccatga aattggagga gtttgcccaa ttggatagac
    21601 tcatgatcct ga
//
