LOCUS       NZ_NIUP01000031        25238 bp    DNA     linear   CON 19-MAR-2024
DEFINITION  Bacillus mycoides strain MOD1_Bc228 Bc228_contig_31, whole genome
            shotgun sequence.
ACCESSION   NZ_NIUP01000031
VERSION     NZ_NIUP01000031.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 100870)
  AUTHORS   Chase,H., Gopinath,G., Tall,B. and Carter,L.
  TITLE     Bacillus cereus isolated from various food and clinical sources
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 100870)
  AUTHORS   Chase,H., Gopinath,G., Tall,B. and Carter,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2017) US FDA, CFSAN, 8301 Muirkirk Road, Laurel,
            MD 20708, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-DEC-2016
            Assembly Method                   :: CLC NGS Cell v. 8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002200005.1-RS_2024_03_19
            Annotation Date                   :: 03/19/2024 02:45:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,644
            CDSs (total)                      :: 5,560
            Genes (coding)                    :: 5,360
            CDSs (with protein)               :: 5,360
            Genes (RNA)                       :: 84
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 91 of 200
            Pseudo Genes (incomplete)         :: 129 of 200
            Pseudo Genes (internal stop)      :: 46 of 200
            Pseudo Genes (multiple problems)  :: 56 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:21:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8870
            Orig. end                         :: 34108
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NIUP01000031.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25238
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25238
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25238
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15238](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15238)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(185..795)
                     /gene="yqeK"
                     /locus_tag="CEU84_RS25145"
                     /pseudo=""
     CDS             complement(185..795)
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="CEU84_RS25145"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLYNDIYSFTPTGKIENDIKAFLLKYNKEFTYKHSIRVANEARKI
                     AGIFYEDEEKAAIAGCLHDISAIFPNEERIAVAEEFGIEILQEEREFPMIIHQKLSSVI
                     AKEIFKIEDEEVLNAISCHTTLHKYAT"
     gene            993..1688
                     /locus_tag="CEU84_RS25150"
     CDS             993..1688
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="CEU84_RS25150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_002016575.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKDIVELLAVYLRNEGYNIYKAYDGDEALQMICTY
                     EVDLMLLDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            1678..2835
                     /locus_tag="CEU84_RS25155"
     CDS             1678..2835
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127015.1"
                     /locus_tag="CEU84_RS25155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_002085430.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIFRLVTSVIES
                     SLTLSELGKEFIRIFGHEKYIGLKESLWMMIVSYLFLFSIFSSYLYIFYRHERKVYYET
                     CIKKMIEEIRYIASGNFNHKVSIVHHNYLEELATGVNQIIEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSAPIDIVELLGQLTVQFRIQLQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAITYGNDGDHIDITAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLLPYKA"
     gene            3017..4033
                     /locus_tag="CEU84_RS25160"
     CDS             3017..4033
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="CEU84_RS25160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_088291574.1"
                     /transl_table=11
                     /translation="MQFLKKITVLLLSFLITALIVLYFYLYVNGPIIQAKSAILIDTNS
                     GEIVYKKNEETPIQSATLSKLMTEYIALEQLNEGKIQLDELVKISNEVFRAETSAIQVT
                     SKDKTTVRDLLHALFLTGNNRSALALAEHIAGNEDNFTLLMNDKAKQLKLSQPSPFLNA
                     TGINNDTNKQSTTTSIDVAKLATQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTATRGDTRLISVILDAGDENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTILFQFKNLIIQMIMIFFIITILMFLYIRQKKAEDFN"
     gene            complement(4092..>4325)
                     /locus_tag="CEU84_RS25165"
                     /pseudo=""
     CDS             complement(4092..>4325)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="CEU84_RS25165"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="KSLSDLYRRELDNFLQLWSGDFESKILKASWTDKTYKYGEVLMHV
                     IVHEIHHIGQISIWARELNLQPVSANLVGRGL"
     gene            complement(4346..4906)
                     /locus_tag="CEU84_RS25170"
     CDS             complement(4346..4906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127500.1"
                     /locus_tag="CEU84_RS25170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002127500.1"
                     /transl_table=11
                     /translation="MNKKTKIISIAAVSGGGKTTITESLAHELKKSKALYFDRYKFDNC
                     PVDICKWIDDGANYDEWVLTPLMNDIQRSIQDSSLDYIIVDYPFAYLNREVGQFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNNLKHYMTHARKAYLEAIHTVKPNSDIVLDGS
                     LSISEIIDQIIEELNRREVIVNG"
     gene            complement(4956..5468)
                     /locus_tag="CEU84_RS25175"
     CDS             complement(4956..5468)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127499.1"
                     /locus_tag="CEU84_RS25175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_002127499.1"
                     /transl_table=11
                     /translation="MIKLKQFTRSDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLEKY
                     TECANTLAFKIMDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMMKA
                     VLCIAFDELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMSML
                     EYEWNNK"
     gene            complement(5593..5949)
                     /locus_tag="CEU84_RS25180"
     CDS             complement(5593..5949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002032241.1"
                     /locus_tag="CEU84_RS25180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002032241.1"
                     /transl_table=11
                     /translation="MGSRFNNCRKKCTCKHDDCWDIFEECKKEKNEKCDSSCVQGIRDE
                     LKKLINKTVRINTEGRTYIGTVSSVTCDVVKLAAIPGSVAAIISLCKIEAILPPATTVT
                     DEFDFNGVDVANKD"
     gene            6411..6713
                     /locus_tag="CEU84_RS25185"
     CDS             6411..6713
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CEU84_RS25185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_170935234.1"
                     /transl_table=11
                     /translation="MKGGIKECPGKMIAGVLRKSIVVMTGGNLKKRIIVMMIGVLRKSI
                     VMMIGGNLKKRIIVIMIGVLNEISVVVNVSLFVVIVKEKVGNIFNIDLKERTCLL"
     gene            complement(6821..7201)
                     /locus_tag="CEU84_RS25190"
     CDS             complement(6821..7201)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="CEU84_RS25190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002127497.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGSVILHNVWVFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRVLS
                     TRIALAIIGALALWMLIVIYIK"
     misc_feature    7310..7323
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(7311..7324)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            7865..8233
                     /locus_tag="CEU84_RS25195"
     CDS             7865..8233
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="CEU84_RS25195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="septum formation initiator family protein"
                     /protein_id="WP_002127495.1"
                     /transl_table=11
                     /translation="MGNIPKISSQQSNPKIPSQQVNANTKQSNNKKTRRRIITTLAFIL
                     PIIFVLQYSLNNQQEMIKEKQITVNTEQQKLSSLKKDGHSLKNDVKALTGSEEEILKFA
                     RKLYEFSKPNETIFQITE"
     gene            8432..>8488
                     /locus_tag="CEU84_RS29995"
                     /pseudo=""
     CDS             8432..>8488
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="CEU84_RS29995"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLYFAALNPGSIGPTL"
     gene            complement(8506..8781)
                     /locus_tag="CEU84_RS30000"
     CDS             complement(8506..8781)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="CEU84_RS30000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_234817333.1"
                     /transl_table=11
                     /translation="MVSLEVKVIEAGPAGRLNPVGPVGPVGPVGPVGPVEPVDPVGPVG
                     PVEPVDPVDPVGPVEPVDPVGPVGPVEPVDPVEPVAPVEPVGPVGN"
     misc_feature    complement(8790..8807)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            complement(8827..9042)
                     /locus_tag="CEU84_RS30005"
     CDS             complement(8827..9042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="CEU84_RS30005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002085442.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTVTVPGPLAARNTAVKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNT"
     gene            9360..9557
                     /locus_tag="CEU84_RS25205"
     CDS             9360..9557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="CEU84_RS25205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002017016.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDPVSLDALNTPSKAQEQLQETSQEAHNSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            complement(10001..11941)
                     /locus_tag="CEU84_RS25210"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (95-521). E-value: 2.4e-82.
                     Score: 268.6. Matches aSDomain:
                     nrpspksdomains_CEU84_RS25210_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="CEU84_RS25210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_002127493.1"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-89, bitscore:
                     291.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLFGWMKSLGYEDYEAFYNKSIEETAWFW
                     GEAERAVGYQWMKPYTEVLDLENGTPFAQWYTEGTCNVVESALSRWLADDKTKTQAALM
                     YEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAVGVPDDVKGEVCHCFVVLRDGVTFSGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CEU84_RS25210_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="CEU84_RS25210"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11656)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CEU84_RS25210_AMP-binding.1"
                     /evalue="2.40E-82"
                     /label="CEU84_RS25210_AMP-binding.1"
                     /locus_tag="CEU84_RS25210"
                     /protein_end="521"
                     /protein_start="95"
                     /score="268.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KTKTQAALMYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGD
                     RVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRR
                     GKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNS
                     DDPLMLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPF
                     LLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNK
                     HSLKSLEVFASTGEPWNPDPWMWLFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAP
                     ISFNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFEN
                     KWVHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CEU84_RS25210_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="CEU84_RS25210"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11990..13531)
                     /locus_tag="CEU84_RS25215"
     CDS             complement(11990..13531)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="CEU84_RS25215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_002017014.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLITPQEPKQFDKTLEEIIPENQNAPFNM
                     KDLINRIIDEGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYRLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13534..14322)
                     /locus_tag="CEU84_RS25220"
     CDS             complement(13534..14322)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 4.4e-75. Score:
                     244.1. Matches aSDomain:
                     nrpspksdomains_CEU84_RS25220_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="CEU84_RS25220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_002017012.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRERQANSLSLALLEELQTILTQI
                     NEESNTRVVILTGDGEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRKPMYKGE"
     aSDomain        complement(13561..14280)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CEU84_RS25220_ECH.1"
                     /evalue="4.40E-75"
                     /label="CEU84_RS25220_ECH.1"
                     /locus_tag="CEU84_RS25220"
                     /protein_end="254"
                     /protein_start="14"
                     /score="244.1"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQTILTQINEESNTRVVILTGD
                     GEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            complement(14327..15238)
                     /gene="mvaB"
                     /locus_tag="CEU84_RS25225"
     CDS             complement(14327..15238)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="CEU84_RS25225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_002017011.1"
                     /sec_met_domain="HMGL-like (E-value: 1.4e-50, bitscore:
                     164.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADASDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15260..15475)
                     /locus_tag="CEU84_RS25230"
     CDS             complement(15260..15475)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="CEU84_RS25230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001985297.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            complement(15502..16839)
                     /locus_tag="CEU84_RS25235"
     CDS             complement(15502..16839)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="CEU84_RS25235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_002127492.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.4e-12,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 5.9e-08, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 4.8e-08, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.8e-11, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKLA
                     NEAYLVGGPRVQESYLNLEKIMEIAKKTNAEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNIRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LKIALEELKVEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     gene            complement(16855..18000)
                     /locus_tag="CEU84_RS25240"
     CDS             complement(16855..18000)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="CEU84_RS25240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_002032227.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.8e-41, bitscore:
                     131.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.3e-28, bitscore:
                     89.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.9e-59, bitscore:
                     192.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTLSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKFLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGFEDNGKKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKPISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERYIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18217..19185)
                     /locus_tag="CEU84_RS25245"
     CDS             complement(18217..19185)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="CEU84_RS25245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_088291576.1"
                     /transl_table=11
                     /translation="MRQFAKPIIVVSKCLEFDACRYNGEMVPDLTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEKNGANRLVQPSIREDVTEKMNEFLNAFLQTLPEVDGFILKN
                     RSPSCGTRDVKIYSGFEKGPVKGKGTGLFGGAVIKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVAFQSDYKYLFMAYNQVKQKELGRIIANQKNETIEVVFD
                     NYEKTLYELFIRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLELLQKYSEKKIPLSSL
                     LVILKTWAIRFDEKYLLRQTYFEPYPEGLVEISDSGKGRDY"
     gene            complement(19190..19843)
                     /locus_tag="CEU84_RS25250"
     CDS             complement(19190..19843)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="CEU84_RS25250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002032224.1"
                     /transl_table=11
                     /translation="MKKDWLEELVAATNADKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLFAVVMPTLTKFAAPFFVQAFAKEIFKTEYESYEVLL
                     RVIIQNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLIETELLVHFKKLIAKFQEEGE
                     IIELPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRR"
     gene            complement(19868..20887)
                     /locus_tag="CEU84_RS25255"
     CDS             complement(19868..20887)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="CEU84_RS25255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_002127488.1"
                     /transl_table=11
                     /translation="MRVNGVVIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLIFTQKDYI
                     PHIAVVDVPAPIVKAMKNQEASIYEYSKDKAISELEKQKVDAVIHLENGKMNLLLEGSD
                     SSKNRAVLQVLQKSTEKNNVSMMKPEVDYLHGSKDITMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVLGYIIGFGIFALIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQVFFSGLFPMESMNTW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            complement(20884..21609)
                     /locus_tag="CEU84_RS25260"
     CDS             complement(20884..21609)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129461.1"
                     /locus_tag="CEU84_RS25260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088291577.1"
                     /transl_table=11
                     /translation="MQQPSIILRDVSKKFGKKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKMIAGINDSTTGDVIVFNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKERIVEVFELLQLSEHTKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKSIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     QTSSGRIEDVFMLEGVIES"
     gene            complement(21794..22045)
                     /locus_tag="CEU84_RS25265"
     CDS             complement(21794..22045)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="CEU84_RS25265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002017002.1"
                     /transl_table=11
                     /translation="MHKEFEIEEYTAIEEQIHYYSTSLLVSHPEQIVKYLEKRLEKYAE
                     TLQYAHLYPETVILPIQQIVIEYSLDVARIRRYLNLKT"
     gene            complement(22262..23104)
                     /locus_tag="CEU84_RS25270"
     CDS             complement(22262..23104)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="CEU84_RS25270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_002032218.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.2e-10, bitscore:
                     34.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIKRIILIIGILVGISIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKVKSINPDIIAITGDLIDSKSYDAEMSMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKKLKKQHVTVLRNEHVIIQKGGHEINLLGIDDPEF
                     NTGDIDEGSIVKDAIVKAKIETLPDRYNVLLSHRPEFLEAYADEQVDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYEQQNTSMIVSRGLGNSIIPQRVFNRPEIVVVQLN"
     misc_feature    complement(23149..23167)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     misc_feature    23242..23257
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(23365..23378)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            23705..24274
                     /locus_tag="CEU84_RS25275"
     CDS             23705..24274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="CEU84_RS25275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002127485.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPSTSVFAAEKEAPIQQEETQMSI
                     QPFAQNNLETAVKAALNGPEVKKIKVFEHEFNVKPIEVVNLGGGKTYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFTAPLLSILAAYNGIPVNPNDLNALGQQ
                     IGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    complement(24473..24486)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.02"
                     /tool="antismash"
ORIGIN
        1 atacctatat agttgtgtaa aatattccat attatacgtg ttaccatctt ctttgaattg
       61 atatttatct ttcccaaaat caaaatgaag atgattttcc cactgaaagt atatggacgg
      121 tactaacgta actcctggga atgtttgatt catatattct tttaattgca tttttatacc
      181 ctttctactc tacaatttct tttaaatacc aatatgcttc ttctaaccac gggtgtatga
      241 cttttaatgt atattttctt tcccacaaat atgaaatata tatacaaaag cagcatgttc
      301 caaagatttt tccaatcctt tttttacctc aattaaatat gacggtgtcc ctatttgatc
      361 ccattctaat ttatcagcaa taaataatac taaatccatc tacgttgcat atttatgcaa
      421 cgtagtgtgg caactgattg catttaaaac ttcttcatcc tctattttga atatctcttt
      481 tgcaattaca ctcgataatt tttgatgaat aatcattgga aactctcgtt cttcttgtaa
      541 tatttctatg ccaaattctt cagcaactgc aatccgctcc tcattcggaa agattgcact
      601 aatatcatgt aaacaccctg caatcgctgc tttttcttca tcttcataaa atattcccgc
      661 aatttttctc gcctcatttg ccacacgaat tgaatgttta tatgtaaatt ctttattgta
      721 ttttaataga aaagctttaa tatcattttc tatttttcca gttggagtaa atgaatatat
      781 atcattatat aacatagcaa gtccccctta taactatctt tcagtataat gtggagttta
      841 aatatccttc ttattttata ttcgttatga atgttttaat tcctttttaa tacgatacat
      901 gaaattttat gtagaaacat tactacaaaa tacataaatg tttgatatta tagtaatgtt
      961 gattaattgt aaggaaagga actaactata aaatgaataa aaacatatta attattgatg
     1021 atgataaaga tattgtagaa ttactggctg tttatttacg aaatgaaggc tataacattt
     1081 ataaagctta tgatggtgat gaagcattac aaatgatatg tacatatgaa gttgacctta
     1141 tgcttttaga tattatgatg ccaaaacgaa acggattgga agtttgtcaa gaagtgcgtg
     1201 aaaataatac tgtacctatc cttatgctta gtgcaaaggc tgaagatatg gataaaattt
     1261 taggacttat gaccggcgca gatgattata tgattaaacc gtttaatcca ctagaattag
     1321 tggctagagt gaaggcttta ttacgaagat cctctttcca aaatgctact tcccaaaaga
     1381 atgaagatgg tattattcgt attcgttctg ttgaaataca taaacataat catactgtta
     1441 aagtaaatgg agaatatatt aaactcacct ctatcgaatt tgatatttta tatttactag
     1501 cgagtaatac tggaagagta tttagctctg aagagatatt cgaacgagtt tggaatgaag
     1561 acggttatgg ttctaataaa acggtaatgg tccatattag taatttacgc gataaacttg
     1621 aaaccgtaat gaatggtgaa aaactaattc atacggtttg gggagtagga tataaaattg
     1681 agaaatgaag catttgatat attaaaagat ataccaaagt ggaagcttat tttttggctt
     1741 ttattagcta tcactcttac accaattacc gaattaatta tatttcgcct cgtaacgagt
     1801 gtaattgaga gttcacttac tctaagcgaa ctaggaaaag aattcattag aatttttggc
     1861 catgaaaaat atattggatt aaaagagtct ttatggatga tgattgtatc ttatttgttt
     1921 ttattttcta ttttctcatc ctatttatac attttttatc gtcatgaaag aaaggtttac
     1981 tatgaaactt gtataaaaaa aatgattgaa gagattcggt atattgcaag tggaaacttt
     2041 aatcataaag tttccatcgt acaccataat tatttagaag aactggcaac tggggtcaat
     2101 caaattattg agcaattaaa agtttcgatt gatgaagaaa gacaggcaga acaagcaaaa
     2161 agcgaactta ttacaaatgt atcacatgac ttacgaaccc ctcttacatc tatagttgga
     2221 tacgtaaatt taatccatca tgataattat agagatgaag tagaattacg atactatatt
     2281 caagtcattt acgataaagt aactcgtctt aatgcattaa tgaatgactt gtttgaatat
     2341 acacgcgttc aaaataaaga gttaagttta tattctgctc ccattgatat tgtagaattg
     2401 cttggacaat taactgtcca atttcggata cagcttcaag aagctaatat tgaatgtcgc
     2461 ccttctttcc catctcaaaa gctaatggta ctagctgatg gggataaatt agtacgtgtg
     2521 tttgaaaatc taatcataaa cgctattact tatggaaatg atggagatca tattgatatt
     2581 accgcttacg aaagcaataa catgattaca attgatataa caaattacgg acaacctatc
     2641 cctagtactg atttacctca tatttttgaa cgtttttatc gtgttgaaaa atcacgttca
     2701 acaaacactg gtggatctgg gctcggatta gcaattgcaa aaagtattgt tgaattgcat
     2761 aaaggaacaa ttgaagtata tagcgatgat aaaaaaacaa ctttcactgt aaaattactc
     2821 ccttataaag cttaatacca catatttata ggttcaattt tttatcatat aaaaaattga
     2881 accttttata ttccatcaat atccaaaatt taataatcct ttataattct ttagaaattc
     2941 tttacctttt ctttcttcct aattaagcat tcctttttac aataatatta ttgatgtaat
     3001 agtaggagga tcgctaatgc aattcttaaa aaaaataaca gttttattat tatcttttct
     3061 tattactgca cttatcgttt tatattttta tctttatgta aatggtccaa ttattcaagc
     3121 taaatcagct attttaatag atactaattc tggtgagatt gtttataaaa aaaatgaaga
     3181 aactcctata caatcagcta ctttatctaa attaatgaca gagtatatcg cactggaaca
     3241 actgaatgaa ggaaaaatac agttagatga attagtaaaa ataagtaacg aagttttccg
     3301 agcagaaacg agtgctatac aagtaacttc gaaagataaa acgacggttc gtgatttact
     3361 tcatgcattg tttttgacag ggaataatcg ttccgcactt gcccttgcag aacacattgc
     3421 tggaaacgaa gataacttta cacttttaat gaatgacaaa gcaaaacaac taaagttatc
     3481 acaaccatcc ccgtttctaa atgctactgg aattaataac gatacgaata aacaatcaac
     3541 tacaacatcg atagacgtcg ctaaactagc aacacaatta gtaaaagact ttccagatgt
     3601 attgaatgtt acgaaactaa cctcttacca atttaccttc aaagattcaa aagttttcaa
     3661 tacaaataaa atgatatatt cccttaataa aaacattaaa ctccaaggtg ttgacggctt
     3721 acaaactagt ttttcaacta atggtaatta tagttttgtc agtacagcca cacgaggaga
     3781 tactagactt atttcagtaa tattagacgc cggtgatgaa aacagtactt ttattgaaac
     3841 aaaaaagtta cttcagtacg gttttgatcc ttcctcgtac tctgcactcc aagcttttaa
     3901 agatgctgtt acatcttgga caatattgtt tcagtttaaa aatttaatca tacaaatgat
     3961 tatgatcttt ttcatcatta caatcttaat gtttttatat atacgtcaaa aaaaagccga
     4021 ggattttaat taagaaatct tcttatattt agaaaccgac ttgcgtttac actgcaagtc
     4081 ggtttctaaa tctacaatcc tcttccaact aaattcgctg aaacgggctg aagatttaat
     4141 tctcttgccc atatagatat ctgaccaata tgatgaattt catgtacaat tacatgcatt
     4201 aaaacttcac cgtatttata tgttttatct gtccatgaag ctttcaatat ttttgattcg
     4261 aagtcgccag accataactg caaaaagtta tctaattctc gtctatataa atcagataat
     4321 gacttgtaca tatcgtttta tacatttaac cattcacaat cacttctctt cgattaagtt
     4381 cctctattat ttgatcaatt atttcactta tagataaaga tccatccaat acaatatccg
     4441 aattcggctt aacagtatga attgcctcta aataagcttt tctcgcatgt gtcatgtaat
     4501 gtttcaaatt attatgtatt tcactcattg tatcttcttt aaaatctctc aaaattcttc
     4561 tagccatcgc aatatctaaa ggtgtatcga taaatatagt tacatcaatg aattgtccca
     4621 cttctctatt taagtatgca aaaggataat ctacaataat ataatctaaa ctactatctt
     4681 gtatagaacg ctgaatatca ttcattagcg gtgtaagtac ccattcatcg taattagctc
     4741 catcatcaat ccatttgcaa atatcaaccg gacagttatc aaatttatat ctatcaaaat
     4801 atagagcctt tgattttttc aactcatgag ctaaactttc tgtaatggta gttttaccgc
     4861 cccctgaaac agctgcaatt gaaattattt ttgttttttt attcacgatt cccaccaaac
     4921 cccttttgtt aacataatat aattataaaa tactattatt tattgttcca ttcatattct
     4981 aacatactca tttcccataa attccaatac gtttctccta ctctttttga ctctcttaat
     5041 aaaccttctt ttacaaaacc tattttttcg taacaagaaa tagctgactt attaaagtca
     5101 taaacaccaa gagttactct atgtagtttt aattcatcaa aagcaataca aagtacggct
     5161 ttcatcatat gtttccctat agaacgccct ctcattttcg tattaccaac tagcactttt
     5221 ccaattctag cagacttatt tatattatct atttgtccaa gagaaatatg accaataact
     5281 gctttagtct cttcatccat tattttgaat gccagtgtgt ttgcacattc tgtatatttc
     5341 tctaattgct gttcatttaa aggatatgtg aatgcatttc ccgaccattg tattaaaaat
     5401 tcttcggaat taatccaatt tattaattgt ttgaaatcag atcttgtaaa ttgtttcagc
     5461 ttgatcactc tcattctcct ttcacacaac cttttataca ccttcaaatt tatttctata
     5521 tgaaaaatat attccctttt aaacaaaata aaaagccatt cataagaatg gcttagcatc
     5581 aataaagcat aattaatctt tatttgctac gtcaacaccg ttaaaatcaa actcatcagt
     5641 aacagttgta gcaggtggta aaattgcttc aattttacaa agagatataa ttgctgcaac
     5701 tgaaccagga atagcagcta gcttaacaac atcgcaagtt accgaagaaa cagtacctat
     5761 ataagtacgt ccttcagtgt taattcgcac tgttttatta attaattttt taagctcatc
     5821 tctaattcct tgtacacaag agctgtcaca tttctcgttc ttttcctttt tacactcttc
     5881 aaaaatgtcc caacaatcat catgcttaca cgtacatttt tttctacaat tattaaatcg
     5941 agaacccaaa acctcacccc ctaatccttt ctactagtaa agtatgtcca atagcttaaa
     6001 agtgtacgag acaaaagcat agaaacaaaa aaacaaacac ttgtactaaa ccttcttatt
     6061 tatactttta ataagccggc tccttgaata gggaccacct tttcctatta cttcacatat
     6121 acataggctt tgttcgcagt gatatggtgt atttttcctt taccattgtg aaatatacat
     6181 tcagaaaagc gtactccaaa ataagatatt atttaaaatc ttaacgtttc cttcaacaag
     6241 tgtttgttga ttaatatcat aaccagtagt tctctcaact atctcttgaa aattagcata
     6301 gtttgtatga attctatatc tagtagaaaa cactctatca tataaaggta aaataatagg
     6361 ttaataaaca agccattctt ttactaaaac atagaatagt atgaatccta ttgaagggag
     6421 gtataaaaga atgtcctgga aaaatgattg ctggagttct aagaaaaagc attgttgtga
     6481 tgactggtgg aaatctaaag aaaagaatca ttgtgatgat gattggagtt ctaaggaaaa
     6541 gcattgtaat gatgattggt ggaaatctaa agaaaagaat cattgtgata atgattggag
     6601 ttctaaacga aataagtgtc gttgtaaatg tttctttatt tgttgtcatt gtaaaagaaa
     6661 aagttggtaa cattttcaat atcgacttaa aagagagaac atgtcttttg tgaccgataa
     6721 atactagaat gtaatataca aaaagctgac taagtatagt cagctttttg tcaatgaaca
     6781 cgtagagatt tattttaata tagttcttat tagaaaatga ttattttata tagattacta
     6841 taagcatcca taaagccaag gcgccaatga tagcgagcgc tatacgtgta gatagtaccc
     6901 ttaattcaaa gtctgttttc ttggagggtt caggatatgc aattatgtag attcccttta
     6961 ataatgcaag ccatgcaata accgttagga acccctgcca gttgaatacc catacattat
     7021 gtaggattac actacctaac cctaggaaaa tcgatagaaa accatacata ataccaaatc
     7081 ctctgtcttc aaccactaat tttttcaatt cacgtagtac cgatggacgt acgaaaagta
     7141 ttcccgatac gataaccgtt atccatcccc aaaacaatcc taaaaaagta ctagtttcca
     7201 ttattagttc actcccctca attatttata ttccagatat cccccccttt agaacaattc
     7261 caacatcttt atatataggc taaattctgc tcttttttaa tacaaacatg gcatattcta
     7321 tgcccatcct taatcacctc atttctctac aaaatgaaat ttttatatca ttcttcatca
     7381 tctatccgaa tcaaccgaag tcgctttgta ctattaccgc acactttttc atatcttgga
     7441 gctaacatgc accaacgcca atataatgat ttattcgcct tttcacttac ctctaaaatt
     7501 atcccctctg taataaaatg atcaccttga tacaatgtat actcgcttgt cccatggaat
     7561 catcattatt cccctcccta ttaaaatagc gtttttgttt caaataatgc tctcattaat
     7621 ttggacgcat ttaccagtat atttaccaaa aaattcatga tatcgttaac tagtcgagta
     7681 cgtcattact tgacgattac ccttaggagc cccgcagaca atcggggttc cttttattta
     7741 aataaggatt ttgtttaaac tttacaaaac tcacctatat taaactatct tctagaattc
     7801 ccattgaaca tttataatac ttttaaacag tttaaattct acaatcagta atggaggcat
     7861 tttaatggga aacatcccaa aaatatcatc acaacaatca aatcctaaga taccctcaca
     7921 gcaagtgaac gctaacacca aacaaagtaa taataaaaaa acaagacgcc gtattataac
     7981 tactttagct tttatattac ctataatttt tgtccttcaa tattctctta ataaccagca
     8041 agaaatgatt aaagaaaaac aaatcacggt taatacggag caacaaaaat tatcttcttt
     8101 aaagaaggat ggtcattccc ttaaaaatga tgttaaggct ttaacaggta gtgaagaaga
     8161 aattttaaaa ttcgcaagga aactgtatga attttccaaa ccgaatgaaa ctatatttca
     8221 aataactgaa taaaattaca ctgcattacc ccaaaaggcg atttgacgat aatcgccttt
     8281 ttatatttaa tttctaaaat aaacatacta atttcttttt ctatcaaata actattttgt
     8341 ttaatttatt aaaatacaac cgcttgtcca tttcacattg ctctatcatt acatttacta
     8401 ttagtaatac gatttttaga ggtgataaat aatggacgag tttttatatt ttgctgcact
     8461 taatccgggt tctattggac ctacacttcc acctgttcaa ccctttcaat tccctactgg
     8521 tcccaccggt tctacaggag ctactggctc aaccggatca actggttcta ccggaccaac
     8581 tggaccaacc ggatcaactg gttctaccgg accaaccgga tcaaccggat caactggttc
     8641 taccggacca actggaccaa ctggatcaac tggctctacc ggaccaactg gaccaactgg
     8701 accaactgga ccaactggac caactggatt taatcttcct gctgggcctg cctctattac
     8761 cttgacttct aacgaaacca cagcatgtgt atccactcaa ggaaataata ctttattttt
     8821 ttcgggtcaa gtattagtaa acggtagtcc tactccagga gtagtggtca gtttttcatt
     8881 cagtaaccct tctcttgctt tcatggttcc tcttgcggtc attaccaatg cttcaggtaa
     8941 ctttaccgct gtatttctag ccgctaatgg gcctggaaca gtaaccgtta ctgcttcact
     9001 tcttgattct cctggaacaa tggctagcgt cactattacc attgtgaatt gtccgtaatg
     9061 gttttatttt taaggactaa gcaatatcta ataagatgag cactgattta cagtgctctt
     9121 ttttatcatt gggatgttcc tttcaaatga aatttcgtaa cagcctacta aaataacgct
     9181 tttattaaga actaatgatc tttatatttc ttaagcttgt cagcacaagt aatttttata
     9241 attagttaaa ttctcaatat agtttgtgta tataattcca ttcaaagata cataataccc
     9301 acgtaactat ttaaaaatac tttgttttta tatctaagtt caaaaaggag ctacataaca
     9361 tggataaaaa agatttatta agtcaacaac ttgatcctgt gtcattagat gcgctgaata
     9421 cccctagtaa ggcccaagaa caactgcaag aaacctctca ggaggcacat aattcaaaca
     9481 aaaaggacag tactcaagct ttacatggcg aagatttacc aatttcagat gtatatagaa
     9541 caacgaacaa acagtaaatt taaaagggaa aaaatcttaa gaacgagtga acttaattct
     9601 tttccctttt cctatttaaa taacactttt atatgaaacc cgtacacatt tttgacacat
     9661 ccactatcac aatctcctga aaattcgtga taatattaat ttgtcggata cgccaaattt
     9721 cgacattgaa cgacaataat atctccctta ttgaatccct gtcccccagg gatttctcct
     9781 tttattcatt acttttttct tcactaaatt ttcattctta acaaaattca ttcactccat
     9841 tgaatagaca gccacagtat cctattttga taaaaactaa aaacaaacag acatacttaa
     9901 cactaatagt agatttttta acttcaaatt tacttttcct ctcttttctt tttgtaaaca
     9961 ttaaaaatga gctctattta catagagctc attcgtaatt ttatagtttg ctagactgta
    10021 gtccttgaat aaagggtacc acttcaggat ttacaagtga cgataaatct cctaattctt
    10081 ttcctaagta agcagctttt atgacacgtc gcattacttt agaatttcgt gtttttggta
    10141 aatcttctac aacgtggatg tcttttggac ataaagcttt accaatatga gagtttacta
    10201 aactcattaa ttctttcttt aattctcctg agaatgttac accatctcgt aatacaacaa
    10261 aacaatgaca aacttctcct tttacatcat ccggtacacc aactgccgct gcttctatta
    10321 catcattatg tttcacaaga atagattcat attcagcagg accaatacgt ttccctgcaa
    10381 tatttagcgt atcgtctgaa cgtcctgtga tgatgtattg ctcaccgtca taaataaccc
    10441 agtccccatg gacccattta ttttcaaagc gtgaccaata tgtgtttaca taacgttcat
    10501 catcttccca gaaacttttc gtcataccta cccaaggttt ttctaaacat agttctccga
    10561 cttcatctcg aattggttta ccttgatcat caagtacaac cgctgccatt cctggtaaag
    10621 atgcgttaaa actaatcggt gcgatcggct taattaggac attcccgaaa atcccacctg
    10681 aaatttcagt tccacctgaa tagttacaaa ttggtacttt acctttacca actgtattaa
    10741 ataaccacat ccatgggtct ggattccaag gttctcctgt tgatgcgaat acttctaaac
    10801 tctttaacga gtgtttattt acatattcat caccttttgc cattaatgca cggattaacg
    10861 ttggtgaaat accgagatga gtaatttcat atttatcgac tgtctcccat aagcggtctg
    10921 cttctggaaa gtctgggaca ccttcataca taaccattgt tgcgccatta attaaagagc
    10981 cgaatagtaa aaatggtccc atcatccagc ccatatcagt tacccataat actcggtcgc
    11041 cttgttttat attcattcca aatcctgcat caaatgcaga ttttagcggg aaaccagcat
    11101 gtgtgtgtac tgtccccttc ggcttaccag tcgttccaga tgtatatata agcattaatg
    11161 gatcatcact gttcatttct tcagcatgta taaatggttt ttctttttct aacgtactcc
    11221 atgaaaaatc ataattatgc ggtgtaaaat catttcctgc atgacgaaca attaccacct
    11281 tttcaacagt tggacaatgt tcacaagctt tatctacttc atcttttaat gaaacaattt
    11341 tcccacggcg tgaaaagcca tctgcggtaa taaccatttt tgaaccagct gcttgtacac
    11401 gtgtcattac tgcatcagca gcaaaacctg agaatattgg tgaaataatc gctccaattt
    11461 tcattaccgc taacatagca acaactgttt caggaatcat tggcatgtaa attgttacac
    11521 gatcaccttt ttcaatacca gcatgtttca aaccgttggc aacacggctt acccagctgt
    11581 caagctcttc atatgtaaat gatttcgaag ttccgttttc cccttcatac ataagtgctg
    11641 cttgtgtttt cgttttatcg tctgcaagcc agcgagataa agcagattct acaacgttac
    11701 aagttccctc agtataccac tgtgcaaacg gtgtaccatt ttctaaatct aacacttctg
    11761 tatatggttt catccactga tagccaactg ctctctcagc ttctccccaa aaccaagctg
    11821 tttcttcaat tgacttatta taaaaagctt cgtaatcttc atagcctaat gatttcatcc
    11881 aaccaaataa acgcgttttt tctttatatt cttctgttgg aaaccaaact gcttgtttca
    11941 tgttttcccc tccttgattt tttgagcaag aaagccctaa atagggcttt taaactggat
    12001 atacaggatg tttacgatcc gtgaatactt gatatttact catatacatt tcgaatcgtc
    12061 cttttagctc ttcacgtaaa ttgtttggat gaacaatacc atcaatcacc atctcagatg
    12121 ctaaacggta aatatcaata tctttcttat actcttctcg tttttcagca ataaagcttg
    12181 cacgctcttc ttctggtaaa gctgctatct tatttgcata tacagcattg accgctgctt
    12241 ctggacccat tactgcaata gaagctgttg gtaatgctaa gcagcaatct ggttcaaacg
    12301 ctggacctgc cattgcatat aagccagctc catatgcttt tcgaacgacg atagaaattt
    12361 tcggtacagt tgcttcactc attgcagaga tcatttttgc accgtgacga ataattccgg
    12421 cacgttctac ttttgtacca atcataaatc caggtacatc tgcaaggaat aataatggaa
    12481 tatggtatgc atcgcataaa tttataaact tcgctgcttt atcagctgaa tcgtggaata
    12541 atacgccgcc cttcatacgc ggctgatttg caataatgcc aattggctta ccatcaatgc
    12601 gtgctaaacc tgtaattagt tcttgagcaa ataatttttt cacttcaaag aaagaacctt
    12661 catcaataat tctgttaatg agatctttca tattgaaagg agcattttga ttttctggaa
    12721 tgatttcttc taacgtttta tcgaactgtt tcggttcttg aggtgtaatc aaaggagtct
    12781 tttctaaata gttacttgga aaataagaaa tatattgtct tgcttgcgta attgcatctt
    12841 cttctgtttt acataaaaca tctccgcatc ctgatactga gcaatgcata cgtgctccgc
    12901 ccatttcttc taaagttacc ttctcaccga taaccatttc agccatacgc ggagacccta
    12961 aatacataga agcatttcct tcaaccatca taacaacgtc acaaaatgct ggaatatacg
    13021 caccaccagc tgctgaaggt ccaaataata aacaaatttg tggcactttt ccagataatt
    13081 tcacttggtt ataaaaaatt cttcccgcac cgcggcgtcc agggaacatt tcaacttgat
    13141 ctgtaatacg cgctccagca gaatcaacta aataaaataa cggtacacgt aatttttctg
    13201 ctgtttcttg aattcgtaga attttttcaa ctgtacgtgc tccccatgat ccagctttta
    13261 cagtcgaatc atttgccatt acgcacgcag tacgaccatg tattttacca gtcgcagtta
    13321 caacaccatc agctggtaat ccagtttgtt cacaatttgc aaataatgca tcttccacat
    13381 attcaccatt atcgaataaa agagctaaac gatctcgaac aaaaagtttc ccttttgctt
    13441 tgttttgttc atgatatttc ggtgccccgc cttgcttaat tgtttcaact cgttcttcaa
    13501 atgaattaga ttgttgtttt tgatctaaca tatttactcc cccttataca ttggtttgcg
    13561 tttttccttg aatgcctgta atccttctaa tctatctttc gtatggatta cgccctcata
    13621 cgcctgtttt tccatttgta agccggtatg taaatctact tgaattccat ttgaaattgc
    13681 ttcttttgct aatcgaacag caattggacc atttttagca attcgatctg caatttcaat
    13741 tgctttctct tctagtaaat cagctggtac tacgaattct actaaaccat attctttcgc
    13801 ttcttgcgcc gaaatacgtc ttcctgtata aattaattct ttcgctctac cgactccaat
    13861 taatctcggt aaacgctgag taccacctgc tccaggtata attgcaagag aagtttcagt
    13921 aagacctaga cttgcagtgt cagaagcaat tctaaaatca caagctaagc ttaattcagt
    13981 acctccacca agtgcgattc cattaatagc agcaataact ggttgtggta attgttccac
    14041 catctccata gtagaacgaa tcatacccac agcatggcga acttgttctt cactcatgtt
    14101 ggcacgctct tttagatcag caccagcgca aaatgctttt tcgccatccc ctgttaaaat
    14161 aacaacgcgc gtatttgatt cttcgtttat ttgagttaat atagtttgta attcttctaa
    14221 taatgccaaa gataatgagt ttgcttgtct ttcacgattt aacgaaatct ttacaacgtg
    14281 cggtgtaaca tagtcaactg aaatgttttg taattgtagc atcttctcac ctacttatcg
    14341 ttttatgttg aagcgctcta tacacatgac tcggtaattg gatatttaac ttactttgaa
    14401 taaactgact agctctcaat aacttttcct catcaatatt agtttggact cccagcttat
    14461 ggagcatatg cactaagtca tcagtagcaa cattacccga tgctcctggt gcataaggac
    14521 atcctccgag tccaccacaa gaactatcaa acgttgtaat accatattct aaagacttaa
    14581 ctacattcgc cagagccatt ccatacgtat tatgaaaatg cattgcaaac tgcgaagcat
    14641 catacttctt taatagatgt tctaatactt gttctacttg taatggattc gctacaccaa
    14701 tcgtgtcacc gagagaaact tcataaatgc cgtatgaaaa tagttgatta catatttcgt
    14761 caactgctgt ggcacttata tccccttcat aaggacatcc aaatacagta gaaacatagc
    14821 ctcttacctt tttaccttcg aacgttgcct gttttgttat atcttcaatt acagctaatg
    14881 cttctttaat agatttatta atattacttt tattgtgaga ttcacttgct gataaaaaaa
    14941 cattcacctc atctacattt tgcaaaaaag ctcgttccaa accattttga tttggaacaa
    15001 gcgctgcata tgtaacattt ggatcccttt ttagctcaga aaacacatca cttgcatctg
    15061 ctaatgcagg aacccattta gggtgaacga atgaggaaac ttcaacgtac gacaatcccg
    15121 cttctgtaag tagttgaatc cattttactt tatcttttgt gccaacaatc tttttttcat
    15181 tctgtaagcc atcacgtggc ccgacttctt taatgacagc aaaattaggt agtttcaatt
    15241 cgcttccccc tatatctccc tattcaattt ctagtaatac atctccttca tttacaaaat
    15301 cgccttcttg tacgttaatt ttcataacag ttccggcttc ttctgaaacg attggaattt
    15361 ccattttcat agattccaaa atgacgacat cctgctcttc ctctactgta tctcctactc
    15421 ccacaacaat tttccaaaca tttcctgcca tcgatgcata tactttcgtc atcatttttt
    15481 cccccttaat attcataact cttatttttt aacaagttgt tttgttacaa aacctgttgt
    15541 ataaatacca cttttgaaca catcgtctcc gagtacttgc agtagcatcg gtgtgtttgt
    15601 tttaatacct tctactttta actcttctag agcaattttt aattttgaaa tcgcttcttc
    15661 acgagtttca ccatgtgcga ttactttcgc aatcattgga tcatagaaag gtgtaatcgt
    15721 tacttgattc tccaaaaagt gatcaatacg tatatttgtc ggtaacgtta aatctgtaat
    15781 tttcccaggt gatgggaaga atgttttcgg atcttctgca taaatacgag cctcaatggc
    15841 atgaccacta cgttttacat catcctgtgt aaatgatagc ttctcaccat atgcgataag
    15901 taattgttgt tcaactaagt ctaacccagt aatttcttct gtaactggat gttctacttg
    15961 taatctcgta ttcatttcta agaaataaaa gttcttttga tcatctacaa gaaactcaac
    16021 tgtacctgca tttgtataac caagtgcttt agcagcttgt acagcaactt ctcccatagc
    16081 ctttcgtgta ccctcatcta aaaatggtga aggtgcttct tcaattactt tttgatttcg
    16141 gcgctgcact gaacattcgc gttcccataa atacactgta ttaccatgtg tatctgctaa
    16201 aagctgaatt tcaatatgat gtgcatctgc tatatagcgt tctaagtaca tttctccgtt
    16261 accaaagaaa ttttgcgctc ttgttttatt actttcaaat gctttggtga gcgtttgctc
    16321 agtttccatc aactgcattc caatgcctcc gccgcccgcg gatgccttaa gcattaatgg
    16381 ataaccaatt tgttttgcaa tttcaattgc ttcttcagca gtttctatat ttgtagtaat
    16441 gcctggaact actggtacat ctgctgcttg catcgctata cgtgactcaa ttttacttcc
    16501 catcttagta atgatttctt ctgaaggacc gataaatacg atgccttctt ctttacagcg
    16561 aatcggaaaa gatggattct ctgataataa tccgtacccc ggatggattg cttcagcatt
    16621 tgtcttctta gctatttcca taattttttc aaggtttaag tagctttctt ggacacgtgg
    16681 accgcctact aagtaagctt catttgccaa ttttacatga agggcatttt catcagcctc
    16741 agaataaata gcaacggtac gaatgccaag tttttgacaa gttttcataa tgcgaactgc
    16801 gatttccccg cgattagcaa ttaatatttt ttgaaacata gtgactcctc ctttttatct
    16861 acatcctaaa tgtcttgcaa ttacgagacg ttgaatttca gaagttcctt caccaatttc
    16921 taaaagtttt gcatcacgaa tatatcgttc aacttcatat tcacgcatat agccatatcc
    16981 accatgaatt tgtactgcat gatttgctat acgacttgca gcttcagatg caaacaactt
    17041 tgccatagcc gcttctttac cgaaaggttt atcgttatct tttaaccaag ctgctttatg
    17101 tactaaatta cgcgctaatt ctacttcagt cgccatatca gccaatttaa attgaatcgc
    17161 ttggaaatta gaaatcggtt ttccaaattg ttgacgttct ttcgcatatt gcaatgcacg
    17221 ttcaaatgca gattgtgcaa tacctactgc taatgctgca attgaaatac gtcctccatc
    17281 aagtgtatat aagaattgtt taaatccttt atttacatca ccaagaatat tttctttcgg
    17341 tacacgtaca ccatcaagta cgatttcaca agtattagaa gcacgaacac ccatcttatc
    17401 gtaagggctt gaaatcgtta atccttcact agtagtcggt acgataaatg cagaaatacg
    17461 ttttttacca ttgtcttcaa aaccgttgat agcggttaca ataattgtat ttgcatactc
    17521 tgcgtttgta atccagcact tttcaccact aataacatat tcatcgccat ctaaaattgc
    17581 tttcgtttgt gtaccccctg catcagatcc agcatttggc tccgtcaatc cgaaagcacc
    17641 taacgtttta cctgacgcca ttggaactaa aaatttctgt ttttgttctt ctgtaccgaa
    17701 ataataaatt ggagaagcac ctaatgaaat tgttgcagca tagcttaaac ctgttccacc
    17761 acaagcacga ccaatctctt caacagctaa cgcgtacgat aacgtatcgc cacctgaacc
    17821 tccatactct tccgggaatg ggatacctaa taatcctagt tcgcccattt tttgaaatgt
    17881 ttcatatgga aattccgcag ttttgtcata atatacagct ttcggtgcga tttccttttc
    17941 agcaaaatca cgtaccattt ctttaatcat ttgtttttcg cgagttagag taaattccat
    18001 tccgctacac accccttatc gaatattgag tttcgacagc gtgcgagttt ctactacaaa
    18061 cattacttct taaaagacac gaatattagt tagacaattg ctataattct gtcataactt
    18121 aattttaaaa cagattctgt accaatgcac aaaaaaattc ctacattgtt ctacaacaac
    18181 ataggaggtt ttgtgtcgaa ttatgtaatt tattgtttaa taatctctac cttttcccga
    18241 atcagaaatt tctactaacc cttcagggta tggttcgaaa tatgtttgtc ttaataaata
    18301 cttttcatca aatcgaatgg cccatgtttt taaaatgaca agtaaactac taagtgggat
    18361 tttcttttca gaatacttct gtaacagctc taaaaaatga tctttttctt gtttttttag
    18421 ctttgtttta aaatatccga aaatgtgctc acatacattt acattcgatg tatagcgagg
    18481 cgcgcgaata aataattcat ataaagtctt ctcatagtta tcaaatacga cttcaattgt
    18541 ttcatttttt tgatttgcaa taatacgccc taattctttt tgtttcacct gattatatgc
    18601 cataaataaa tacttataat ctgattgaaa cgctacgagt tcttttatgt ttttagtatg
    18661 tttaatcatt ttgtaatgcg cgattgtaaa caatcttgta aagaaatgct ctctaataat
    18721 aaaattcgac aatctacctt cttcttcaat tggaagatgc gaaaattttt ttattactgc
    18781 tccaccaaat aatccagttc cttttccttt tactggccct ttttcaaaac cagaatagat
    18841 tttcacatca cgagttccgc aacttggcga acgattcttc aaaataaaac cgtcaacttc
    18901 aggtaatgtt tgtaaaaatg catttaaaaa ttcattcatt ttttcagtta catcttctcg
    18961 tattgacggt tgtacaagcc tattcgcacc atttttttct acaatacgta tcgtttcacg
    19021 aggagtccct aaaccaattt ctacttcagg acatacaggt ataaatgtaa caaatggctg
    19081 caagtttcga attgttaaat ctggaaccat ctctccatta taacgacagg catcaaattc
    19141 taaacattta cttacaacaa ttatcggttt agcaaattgt cgcatcacat tacctccgtg
    19201 gcgttagtcc atacaatata aattgaatcg tattttcaat ttccacttca tcgtcccatt
    19261 tctcttccgg caataataaa aacctcgtta agagcaaccc taatacagct gataaagtaa
    19321 gacgtaatac ggaagatggt ggaagttcaa taatttcccc ttcttcttga aactttgcaa
    19381 tcagcttttt aaaatgtaca agcagttctg tttctattaa ttgttgtatt tcacttttta
    19441 gttccggctg aaatggtact tcttgaatta atatttttat cattggaaag tgctttttag
    19501 caaattcaaa tctattttga attattactc ttaaaagcac ttcatacgat tcatactctg
    19561 ttttaaatat ttcttttgca aaggcttgta cgaaaaatgg tgcagcaaac tttgttaagg
    19621 tcggcatcac gactgcaaac aataaatctt ttttcgtttt atagtagcgg aagattgttc
    19681 cttccgctac accagctcgc tttgcaattt cactcgttga agttgaggcg tacccttttt
    19741 ctccaaacat atcaacagct gcctctaata tacgcatttg acgttcatta cgtttatcag
    19801 cattcgttgc ggcaactaat tcttccagcc aatccttctt catttattgt gctccttttt
    19861 atcatcatta tattttgcga tgtttcttta atgcaaatac atttcctact gcaaataata
    19921 gtgaaaaaag tagtaataca gtaagatcta atgcaatctc tgtaaaccct tgattccgaa
    19981 tcattacttg tctcatagcg tcagcaccat atgtgagtgg aaataattta cctaacattt
    20041 gtaaccatgt attcatggat tccattggaa acaacccaga aaagaagact tgtggcacga
    20101 taacaagcgg tataaattga atcatttgaa attcattatt tgcgtatgcc gataaaaatg
    20161 tgcctaatgt tagtgcagtt aaagaaagca tacatgttat aagtagcgtt agccatattg
    20221 agccagctac atataaatct aaaatataaa ctgaaaaact tacaattata atagattgta
    20281 taagtgcaaa gattccaaaa ccaataatat atcctaaaac tatttcccat cttctcactg
    20341 gtgtggacaa taacctctct aatgtaccac ttaaacgttc tcttacaaaa gatactccgg
    20401 acaatataaa tacaaagaaa aatgtaaaga aaccaattaa tacgggacca agcccatcga
    20461 acatcgtaat gtctttagag ccatgtaaat aatccacttc aggcttcatc attgatacat
    20521 tattcttctc tgtactcttt tgcaatactt gaagtactgc acggtttttt gatgaatcac
    20581 tgccttctaa tagaagattc atttttccat tttctaaatg aattactgca tctacctttt
    20641 gcttttctaa ttccgaaatt gctttgtctt tactatattc ataaattgat gcttcttgat
    20701 ttttcattgc ttttactata ggagcaggta catcgactac agcaatatgc ggtatatagt
    20761 ctttttgtgt aaatattagc gataataacc aaagtaataa cattggtgcc ccaaacatca
    20821 ttgctaaaga acgcttatct cgaaaaaatt gacgaatgat acggatgact acaccattaa
    20881 ctctcatgat tcaatcactc cttctaacat aaagacatct tcaattcgtc cagaagatgt
    20941 ttgttttttc aattcctccg gtgtgccaat cgcaactaaa ttcccttctc taattagccc
    21001 tagacgttcg caaaactcag cttcatccat aatgtgcgtt gttacaataa tagttgttcc
    21061 tttcttttta aggtcataaa acttctccca aatcgatttt cgaagtagag gatctatccc
    21121 aactgttggc tcatctaaaa ttaatatttc tggttcatga aggagtgcta tcgccaatga
    21181 taaacgtttt ttcattccac ctgaaaaatg ctgtacttgc tttttcgtat gctctgataa
    21241 ttgcaaaagt tcaaaaactt ctacgattct ctctttctta cgcttacctt ttaacccata
    21301 catcgttgca ataaaatctg cattttcata tgccgatagt tcttcgtata atgcatcagc
    21361 ctgagccata taaccaattc ttttcatttc atttagatta ggcatgtttg tattaaaaac
    21421 aattacatcc cctgtagttg aatcattaat acctgcaatc attttaatga gtgttgtttt
    21481 ccctgatccg gaaggtccaa ccaagccaaa aatttctgct ttttctactt gcagcgaaag
    21541 gttatgcaaa acttcttttt tcccaaattt ttttgataca tctcgtaaaa taattgaagg
    21601 ttgctgcact aaaaatcccc cttttcttta aaatgagtga gtactcactt ttattttact
    21661 ctcgaattat tatatgtcaa acttttcaaa catatatttt ttctgttatt tactaaatca
    21721 atgaaacaga gtcgacatta gaatatcttt tcttaaagtc gactctgttt cattgtaaat
    21781 tatttgattt ttgttatgtt tttaaattta aataccttct aattctagca acatctaatg
    21841 aatattcgat aactatttgc tgtattggta atataaccgt ttccggatat aaatgtgcat
    21901 attgtaacgt ttctgcatac ttttccaacc gtttttctaa atactttaca atttgctcag
    21961 gatgacttac taataaagac gtactataat aatgaatttg ctcctcaatc gccgtatatt
    22021 cttcaatttc aaattcttta tgcatttgta caccccttta tatttttaat attgcttaat
    22081 aataactatt ttaactcgac taatttttaa gttttttgat tatttacact ataacaaact
    22141 caataggtca aattttgtta ctttatgtaa cgttgaaaaa ttttaacaaa attgtaatgg
    22201 aaacttgtac tcaagaaaaa ctacctttaa attattctcc tgaacaaaaa agccgtacag
    22261 attaatttaa ctgcacgact acaatctcag gtctattaaa aactctttgc ggaatgatac
    22321 tattgcctaa tcctctacta actatcatag acgtattttg ttgttcatat aaacccgctg
    22381 tatatttggg cagtattcct tgattaggag caactaatcc cccgataaaa ggtaaccgaa
    22441 cttgcccccc atgtgcatga cccgataaca ctaaatctac ttgctcatca gcatatgctt
    22501 ctaaaaattc aggcctatgg gataataata cattatacct atctggcagc gtttcaattt
    22561 ttgcttttac aattgcatct tttacaatac ttccttcatc aatatctcca gtattaaatt
    22621 ccggatcatc aattcctaac aagtttattt cgtgtcctcc cttttgtatt attacatgtt
    22681 catttcttaa aacagtgaca tgctgtttct ttaatttttt ttctaaactg ttatatttcc
    22741 ctgaccattt ttcatgattt cctgtcacaa aatataccgg atattccttc acaagttctc
    22801 gtattacttg catactcatt tctgcatcgt acgatttact gtctattaaa tcacccgtaa
    22861 tagcaataat atctggattt atgcttttta ctttttgaat taaaacgtct tgattatcac
    22921 caaatttttt attatgtaaa tctgaaattt gtagtatttt atatccttta aaagaagagg
    22981 gaattttact agaggttatt ttaacctcag ttatacttat taaattgttt tgtaaatata
    23041 aaaagatact aatgcctact aatataccaa taattaatat gattctttta atcttcttgt
    23101 tcatacttcc tcctaaaatc ttaatcagta ctacagttca caataaatat tacgtgccct
    23161 tcgcattcag aataactgaa attttttaat tgatttgtag tatttgttat agttttatac
    23221 gccacttata aaatttttca atcgcatgcg tgtatgatgt catgctcatt tctcagtaac
    23281 tttatagcag atcactggaa tctcttcata atattaacat ttatcttact tcgtttgata
    23341 actatatcat gataattcct atagtttttt ataaaaatat tgtgtacttt tctcgaagta
    23401 tatacgacat ttgattacaa atatattatt accactacga ttttaatttg tttaaaacgt
    23461 acaaagagag aattgaaaca ctaaattgcc ttatgaaaag gtattactgt attatttatt
    23521 agaaaattga aaaaacatgt gtagatagct atcattgtaa gtgcatatat aattaacttt
    23581 aattttctga cataatttca cataattctt aaactatttt tttgcgtgca ttatgaaata
    23641 aaatattgcc ccatgtcagt ctttaaaaaa ttatatatca taactttaag ggaggaagaa
    23701 aactatgaag atgaaaagaa aaatcatgat gacgacagca cttgcagcta cattggctac
    23761 aggtgcacta ccaagtacat cggtgtttgc tgctgaaaaa gaggctccta tccaacaaga
    23821 agagacacag atgagtattc aaccatttgc acaaaataat ttggaaacag cagttaaagc
    23881 tgccttaaat ggtccagaag ttaaaaaaat taaagtattt gagcatgaat ttaatgtaaa
    23941 accaattgaa gtagtaaatt taggtggcgg taaaacatat gttaagggac aaatttctca
    24001 tcatttaagt tttcgtccag atgatcaatt ttattatgag tttacagtgc aagatggaaa
    24061 ggtaatagat aagcctgtat ttaatattga tagaggtggt tggacaccat ttactgctcc
    24121 acttttatca attcttgctg cgtataatgg gatcccagta aatccaaatg atttaaatgc
    24181 acttggtcaa caaattggga aagttataga tggaagctgg gaacatgcag cccaatctat
    24241 cgcaactgta gttagtttaa gttttaatga atagaatttt taaattttta ttagcattgt
    24301 agagatccac ttttcctaag tagccttgtt ataagaaatt ctgaaacagc tataaataga
    24361 tttttaccac tcagtcacat tatcttgatt tgttaaccac cttatcattc attatatgtc
    24421 acaaaataga agtctttttt aagacttctg ttttgtttgt atacagtaca gcggaaagtt
    24481 tgttttttac ccatctatgc ttcaattctt taagaatccg tttgactatt agatacaatt
    24541 tattacaaca aactattaaa atctcaaata acttcctacc ctattttgat tttttcaaac
    24601 acaaaaattc attactttaa gaatgaaaac aatagatgta gtaaaaaatc atcttgtttt
    24661 attatatcta ttgtttaaaa gtcaggagag ataaaatgaa caaaataaaa atgaggaatt
    24721 tttttaaaat tagtatcctt acttgtttca cactagcaag tttaagtaca ccatctacta
    24781 tttttgctga tagtcatcca ggttattcct atgaatccaa tataggctat caaaacccag
    24841 catggatgtc gaaagtagca gattcaacaa aattgagtga aatatctatt ccagggactc
    24901 acggtacaat ggctttacat ggagcaagtt ttcttgatga aaatttgaca agaaatcaaa
    24961 ctatgagtct accacaacaa ttaaattccg gaattcgata tgtagatatg cgtgttaaac
    25021 gtgtaaaaga ttcttttgca atgtaccatg ggattgtaaa tcaaaaagca atgtttgaag
    25081 atgtattaaa agaggcaatt caatttttaa aagatcatcc tacagaaaca attttaatgc
    25141 gcttaaaaga agaaactact cctgaaagtg gctcactatc attcgaggaa atacttaata
    25201 aatacaaaga ccttaattct tcctattttt gggatccg
//
