LOCUS       NZ_NIUP01000001        23909 bp    DNA     linear   CON 19-MAR-2024
DEFINITION  Bacillus mycoides strain MOD1_Bc228 Bc228_contig_1, whole genome
            shotgun sequence.
ACCESSION   NZ_NIUP01000001
VERSION     NZ_NIUP01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 285003)
  AUTHORS   Chase,H., Gopinath,G., Tall,B. and Carter,L.
  TITLE     Bacillus cereus isolated from various food and clinical sources
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 285003)
  AUTHORS   Chase,H., Gopinath,G., Tall,B. and Carter,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2017) US FDA, CFSAN, 8301 Muirkirk Road, Laurel,
            MD 20708, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-DEC-2016
            Assembly Method                   :: CLC NGS Cell v. 8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002200005.1-RS_2024_03_19
            Annotation Date                   :: 03/19/2024 02:45:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,644
            CDSs (total)                      :: 5,560
            Genes (coding)                    :: 5,360
            CDSs (with protein)               :: 5,360
            Genes (RNA)                       :: 84
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 91 of 200
            Pseudo Genes (incomplete)         :: 129 of 200
            Pseudo Genes (internal stop)      :: 46 of 200
            Pseudo Genes (multiple problems)  :: 56 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:21:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 19774
            Orig. end                         :: 43683
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NIUP01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23909
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23909
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23909
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13909](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13909
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            222..1490
                     /locus_tag="CEU84_RS00095"
     CDS             222..1490
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084457.1"
                     /locus_tag="CEU84_RS00095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016120649.1"
                     /transl_table=11
                     /translation="MNSIILDKIVVRNNRVDYSFSIKGDLQKYFKTSNHMFLEYNYDVS
                     DIPLSILAIPFVANVVPLVWITNSTIVINELDKSFYICLNNIKNAYQNMFPGVKFKGSV
                     DVGEIIDNVYIPEFEAASLFSGGLDALTTFIRIKDKKPLLVTEYGWHENEIEGSKVWEA
                     DKENAINFVKDNGLENIFIQSNYGTFIIAGNIDHDFREKLNDTWWHGLHHGLAIISAAI
                     PIAFKLKIKCIYIASSNSPLYQVTCASDPTVDNEIKYASGTVFHDGYELTRQEKIKVVV
                     DHYSASKEPVNIRVCFKNEENCCKCEKCLRTIMGIIAEGRDPREYGFNIPSNLYQYVKT
                     SLNSEVKFFTNTFIEMYWNLIQVRMKQNCDCITDKNLLNWFLDYDFKAQRRKALLKYRI
                     TKFFPILKRKISAKFSRVGTQNN"
     gene            1509..3068
                     /locus_tag="CEU84_RS00100"
     CDS             1509..3068
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001222557.1"
                     /locus_tag="CEU84_RS00100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016120648.1"
                     /sec_met_domain="Polysacc_synt (E-value: 5.3e-09, bitscore:
                     30.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIQNSLKNILFGLSGQIISIGMGFVVRTVFIYTLGIEYLGVDGL
                     FTSILLMFSLANLGFDTAIIYSLYRPLAEKDIYKIQALMNLYQKAYRLIGVVVLLLGLS
                     LLPFLDYLVNADTMIKDINIIYLLFLISSVSSYYFVYKQSIIIADQSNYIISKIHTLFI
                     IISNALQIVLLIIISDYIVVLIVQLTLKVIENVYIANKANKLYPFLKEKNNAKLSKADR
                     REFFENLYSLLLYKISGVVINATDNIIISKFIGIIWVGVYSNYLLILNTLNTLLGYLFY
                     SITASVGNLNVKENAEKKYFIFRVINFFNFWIYGFCTVCLWNLINPFITLWLGEEYVFN
                     KYVLFFILLNFFTSGMQNTTTIFRETTGLFKKGKYRPIIAAIINIVVSIILAKQIGIAG
                     VLLGTVISRLCTYFWYDPYIIFKMIFKKSVKVYFIRYILFVVLVLFSVIATDFIGYIFH
                     INIFMDMVIRSILCLIIPNLIFWMVFKEAEEYRYFLNLTRILIKKIKSKILTRKVSNDN
                     YP"
     gene            3403..5637
                     /locus_tag="CEU84_RS00105"
     CDS             3403..5637
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000269321.1"
                     /locus_tag="CEU84_RS00105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_002014456.1"
                     /transl_table=11
                     /translation="MWRRRDNLGNLNDLDLVSKPPFHNDILTYDSTQLKWIPKSFEATN
                     STSIYVLELDRWDVKNDGTDAINTSKGINNALVWAAQQGYTEVVLPRGIYLIDKQTPIE
                     PPSHLTLNLNGSTLKMETNNLTGYAIISFRRNQVYSRITNGIIQGDRYTHDYSSGGTHE
                     AGYGIELGSFTPPADGGNNTRFVSLDNLDILDCTGDAITLNSTFGQISPFPTALASSFE
                     QGAINTTDGSLVSSTTKIRSNLQIDMTQVAIVKYGYFGLYGNGFGALGSEIKCDYYDVI
                     FYTSNNIFLSSKTNVQFFDEVEVPNGASYAKIVLHQGNVPAPANCLINVRVPSFSQYTY
                     IEKCNLHDCRRQGISVCGAKNVYIRDNDIHHIAGTNPQSGLDIEDGYDLNQYIYIERNN
                     FHDNKNYNIIVVNGKFIYISNNSIMNTISNAYVGLSINGGADRVIVTGNNIRLTKVSLL
                     GDVIFSNNYVYGAQVNVQGVYVNRSINILDNIFSNSKMIIDTPFPYAVKVDSCRFINDA
                     DKLNSLSSLYQWTLEMKNEPQTISNCIFEGQDVLYLNYVPVGTVKSGWIFENIIFNNVK
                     NPTLVAGTYTNCFFKDVTFLGITSTGSTLELKDCKFFSIDRNNTLFTVNNLKAFKMMDC
                     HIEKPNGTVLNIQNVSDEIVLGGNTIKITNDTLQRAIIVLDAAFTGKQVIIQNNIINST
                     NLMQVGIDNRTTSITPLVVIQNNVLNNAKITITGREFLQGNIVNGVIDPN"
     gene            6253..6858
                     /locus_tag="CEU84_RS00110"
     CDS             6253..6858
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002070010.1"
                     /locus_tag="CEU84_RS00110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar transferase"
                     /protein_id="WP_002128595.1"
                     /sec_met_domain="Bac_transf (E-value: 1.2e-70, bitscore:
                     230.7, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLFDIFISLLLLICFFFVILLVAIIVKTQIGSPILFRQQRPGL
                     HGKPFYLYKFRTMTNERDRNGELLQDHARLTKVGKFLRKYSLDELPQLINVLKGQLSLV
                     GPRPLLIEYMPLYSKEQAKRHNVRPGITGWAQVNGRNSISWDEKFKLDVWYVENQSFLL
                     DLKILYLTFSKVLKSEGITNNKHVTMPVFKGGIEHGGE"
     gene            6845..7822
                     /locus_tag="CEU84_RS00115"
     CDS             6845..7822
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002165241.1"
                     /locus_tag="CEU84_RS00115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_033729827.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.5e-24, bitscore:
                     80.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGNKMNILFTSSGRRVTLIKKFKEVLKQEGIKGKIFTADLKETA
                     PTIYFSDKHFIVPRVNEEGYINELLKICKSEMINLIIPLIDTELTLMANNSKVFEGIGV
                     KVLVSSMELNKIANNKKYTYNFFASNNIPTPRVYSDEEIGRKEYQFPLLIKPYDGSSSK
                     GVTKIMNEKELEFFKDYIPNAMIQEYVSGEEYTIDVMVDFCGNIKTIVPRLRIETRAGE
                     VSKGITKKDFDIIQAAETVIKALPNPIGCITLQCFKKEDGQITFIEINPRFGGGIPLSI
                     EAGANFPLWTIKMCQGEVFIDKDFNWRENLTMLRYDEAVFMESI"
     gene            7824..8519
                     /locus_tag="CEU84_RS00120"
     CDS             7824..8519
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016086741.1"
                     /locus_tag="CEU84_RS00120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family hydrolase"
                     /protein_id="WP_002128593.1"
                     /sec_met_domain="HAD_2 (E-value: 3.4e-25, bitscore: 83.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIKAIVFDMDDTLYKEKDYVVSGFKAVDDWIKEKYKKTGFYNIA
                     IQLFDSGERRFVFNETLEKLNIPYDEKLISNLIEQYRFHKPDIQLLDEADWVLNNLVNT
                     VKIGLISDGYLVAQEKKINALKLKERFHSIILTDELGKEYWKPSQIPYEKISKELQVPH
                     QQCVYIGDNLSKDFITAKKLKWLTIHINREGGIHHNLIVEQAYKAHYTIDNLRRLSDIS
                     VLEHMFLDT"
     gene            8550..9713
                     /locus_tag="CEU84_RS00125"
     CDS             8550..9713
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (42-168). E-value:
                     1.2e-08. Score: 26.5. Matches aSDomain:
                     nrpspksdomains_CEU84_RS00125_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000557690.1"
                     /locus_tag="CEU84_RS00125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_050000629.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.4e-98,
                     bitscore: 323.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.3e-08, bitscore:
                     26.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTVQHKKRIYLSSPHMSRNEQKYIQNAFDTNWIAPLGPNVDGFE
                     RELASFVGVKGGAAVSSGTAAIHLALRLLDVQKGDTVFCSSFTFVASANPIVYLGAEPV
                     FIDSEPETWNMSPNALAHALYEANKVGKLPKAIILVHLYGQSAKLDEILSLCNQYNVPI
                     VEDAAESLGSTYKGKASGTFGRFGVYSFNGNKIITTSGGGMLVSNDVEALERARFLATQ
                     AKDPAPHYEHSEIGYNYRMSNILAGVGRGQLEVLEDRVRTRRCIYKRYYEALSHMPGFY
                     FMPELENTRSNRWLTTLTIDEKESGISIGKLLRTLAEENIEARPMWKPLHMQSLFKEKK
                     YYPHSKNEDVSQYLFQSGICLPSGSNMLAEDQQRVIQGILKAVEWKN"
     aSDomain        8676..9053
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CEU84_RS00125_Aminotran_1_2.1"
                     /evalue="1.20E-08"
                     /label="CEU84_RS00125_Aminotran_1_2.1"
                     /locus_tag="CEU84_RS00125"
                     /protein_end="168"
                     /protein_start="42"
                     /score="26.5"
                     /tool="antismash"
                     /translation="GFERELASFVGVKGGAAVSSGTAAIHLALRLLDVQKGDTVFCSSF
                     TFVASANPIVYLGAEPVFIDSEPETWNMSPNALAHALYEANKVGKLPKAIILVHLYGQS
                     AKLDEILSLCNQYNVPIVEDAA"
     gene            10001..11938
                     /locus_tag="CEU84_RS00130"
     CDS             10001..11938
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274520.1"
                     /locus_tag="CEU84_RS00130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_060752001.1"
                     /sec_met_domain="GATase_7 (E-value: 1.3e-20, bitscore:
                     67.6, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 7.7e-24, bitscore:
                     79.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIAGIIHFTNEPVSIEHGREVMSRLYKYPADDIQIWHKENAFL
                     GCHAQWITPESVGEQLPFYNYEKQLAITADAIIDNRDELFEKLQVDYSDRKNMTDSELI
                     LLSYQKWGEAAPKYLVGDFAFMIWDEKKQILFGARDFSGSRTLYFYRGEEKFTFCTIIN
                     PLFSLPYVEKKLNKQWIAEFLAIPVNFESVDPQLTVYKYIEQVPPSHTILVKEGEVKFS
                     RYYTPTVGEMLNLKSNEEYEEAFREVYQSAVKARLRTHHQVGAHLSGGLDSGSVVSFAA
                     SDLRAENKKLHTYSYVPVEGFEDWTHKGRIADERPFIQSTVEHVGNIQDYYLELPERSP
                     LSEIDDWLETMEMPYKFFENTFWLSGVYEKASQNGIGVLLSGQRGNWTVSWGPILDYQA
                     MLLKKLHWIRFYRELHLYSRNIGVKKSRVFEVVRRKAFPFLHQLLFSGKQDANSAIINP
                     EFAREMNVFDRLREQDIDITGTSISNAYDMKREQFEKPYYWSINGTYETKLSLRYALWD
                     RDPTNDLRLIQFCLSVPEEQYVQNGLDRALIRRATKNFLPDKVRLNQRVRGIQGADGVY
                     RMAPFWNEFIEEVEELSVDPVISEFLNVEVIKKAISKICKEPRPEYAFDLDFRILMRSL
                     IFYRFIKKAM"
     gene            11954..12079
                     /locus_tag="CEU84_RS28955"
     CDS             11954..12079
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172970.1"
                     /locus_tag="CEU84_RS28955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_000712621.1"
                     /transl_table=11
                     /translation="MKKEWKQPVLEVLNINMTMAGPGHKYPDAVQPDPDDPVKYS"
     CDS_motif       11954..12013
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKKEWKQPVLEVLNINMTMA"
                     /locus_tag="CEU84_RS28955_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       12014..12079
                     /prepeptide="core"
                     /locus_tag="CEU84_RS28955_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-15.80"
                     /molecular_weight="2264.4"
                     /monoisotopic_mass="2263.0"
                     /core_sequence="GPGHKYPDAVQPDPDDPVKYS"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKKEWKQPVLEVLNINMTMA"
                     /leader_location="[11953:12013](+)"
     gene            12157..13128
                     /locus_tag="CEU84_RS00135"
     CDS             12157..13128
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108921.1"
                     /locus_tag="CEU84_RS00135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldolase"
                     /protein_id="WP_002128587.1"
                     /transl_table=11
                     /translation="MFDSMGNVLYQAFGLKIVSEIPLPELSQLNEKKEMADVQVEITDL
                     SEQWGEYSAEKQKTIVVEDDIVMFHVPQTAIFAIQSGEKITFSPMANAEEDKIRLYILG
                     TCMGALLMQRKILPLHGSVIAIDGKAYALIGDSGAGKSTLASAFLNKGYKLLSDDVVAV
                     SLLNKNTAIVHPSYAQQKLWQESINELGMEVAQFSPLFERETKYAVPVNSQFFPDPLPL
                     AGVIELVKTQGEDIEMTRIEGLARLYKLYRHTFRNSLISKLGLMEWHFETSSNIASGME
                     IFQVSRPASRFTAHELVEVILNTIQKGSMVDGCPLEKNIIRT"
     gene            13091..13399
                     /locus_tag="CEU84_RS00140"
     CDS             13091..13399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128586.1"
                     /locus_tag="CEU84_RS00140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_002128586.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3e-27,
                     bitscore: 88.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.6e-16, bitscore: 54.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVHSRKISLEHNVVQSKGNIVSDMDGEKVMLNVQKGNYYNLGEI
                     GGEIWELIEKPIIINQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQIKDQPNR"
     aSDomain        13130..13378
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CEU84_RS00140_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.00E-28"
                     /identifier="RREFam002.1"
                     /label="CEU84_RS00140"
                     /locus_tag="CEU84_RS00140"
                     /protein_end="96"
                     /protein_start="13"
                     /score="88.7"
                     /tool="antismash"
                     /translation="VVQSKGNIVSDMDGEKVMLNVQKGNYYNLGEIGGEIWELIEKPII
                     INQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQI"
     gene            13436..13909
                     /locus_tag="CEU84_RS00145"
     CDS             13436..13909
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012261438.1"
                     /locus_tag="CEU84_RS00145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_033713202.1"
                     /sec_met_domain="PF13471 (E-value: 2.4e-24, bitscore: 79.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVKRLRMFLSLNMKTKLLFLEAFIFLGWARVLKNITFSKVAPS
                     LGDYMSETSSTHIQPHGDTLKKVSEAISIMSRYTFWESQCLVKAIAGMKMLEKRHIEST
                     LYLGTAKDSHGELIAHAWLRSGSFYVTGSEGMEKFTVVGSFAKRLSEDTIKGE"
     gene            13911..15098
                     /locus_tag="CEU84_RS00150"
     CDS             13911..15098
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002014444.1"
                     /locus_tag="CEU84_RS00150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_002167807.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.9e-68, bitscore:
                     224.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKDFGLNVEFMSKELKLLFTILKLQDDETLQTYSSEWFTDIDWE
                     VFLEQAMHHRVYPVIYQKLKQVDEERIPSHVVQTLNRKYRNNTFQMLYLSAEMERINKF
                     FNENEIRTMFLKGPVLSQDLYGDISLRTSCDLDVLIPVQKLEKVEKLLLEQGYVKDDYI
                     QTILSDWKWRHHHITFFHPTRRIKLEIHWRLNPGPGKEPGFEELWKRKRKSALTSNSVY
                     MLGKEDLFLFLVSHGARHGWSRLRWLVDIKKIVNQDLNWSEINKLMRKYQMFHLGGQAL
                     ILASQMLGARLDKRMMELVAKKRSKQLAQEALFYFKQMINLHTDPVPEEVLAYHSRHLF
                     SLMSNQQKILFIMSQLYPYPIDAKTLPLPKFLHFLYFPLRPFLCLWRKTKKLALS"
     gene            15110..16909
                     /locus_tag="CEU84_RS00155"
     CDS             15110..16909
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="CEU84_RS00155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088290898.1"
                     /transl_table=11
                     /translation="MNHIIYFMKKLYSSAGKILYVNLFGMVLISLLEGIGIILLIPMIS
                     MAGIINIGEETAFIAPVYRFLQDFPKTTSLISILGIYILIVLGQNLLQRNITLRDARTQ
                     QAFVRELRIETYSMILKAKWSFFLEKRKTNLINILTTELARVSYGVNLILQLLAVILFT
                     FIQVGLAFLLSPQITIFVLVFGLLFLVASRAFIKKARILGGKTSKLAQDYLSGITDHFN
                     GIKDIKSNTLEASRLDWLQSITEKMSNEQMEYMRIRSNSQLFYKVSMAILIAFFILLSV
                     SIFKAQPTQLLLIILIFSRLWPRFMTIQSNLEQLAASIPAFKSLWELQGECNEAIEMQD
                     IHQQKHIKPICIEQGIECKGIYFRYNKKEHLYALQNINVKIPINSMTAIVGHSGAGKST
                     LIDVLMGLIQPEKGQVLIDGTPLTSEKLLSLRRAISYVPQDPFLFNASIRENLLMIEPN
                     ASEEQIWTALDFAAAAEFVRMLPKGLDTLIGDRGVRLSGGERQRLVLARAILRQPSILV
                     LDEATSALDTENEVKIQSAIERLKGTMTIVVIAHRLSTIRNADQVIVLGKGEIVQKGEF
                     NQLAKERKGVFRNLLGSQMEVGS"
     gene            17137..17460
                     /locus_tag="CEU84_RS00160"
     CDS             17137..17460
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016105867.1"
                     /locus_tag="CEU84_RS00160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_002066545.1"
                     /transl_table=11
                     /translation="MNVQFKKGVLELCVLALVKRKDCYGYELVQQISNKFLISEGSVYP
                     LLRRLTKEGYFQTYLKESTEGPPRKYYQLTEQGEMQLTLLVTEWRDFAKGVQEIIEGVE
                     WDE"
     gene            17453..17995
                     /locus_tag="CEU84_RS00165"
     CDS             17453..17995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031379.1"
                     /locus_tag="CEU84_RS00165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1700 domain-containing protein"
                     /protein_id="WP_002128581.1"
                     /transl_table=11
                     /translation="MSKEQFLKELSSHLRKLPEEERQDILFDYEEHFQFGMEEGKTESE
                     IIKGLGSPKVIAKDLLAMYRFDEMKKDPSTSNVTRAVMAAVGLSLFNFIIVLGPLVAII
                     AFIFSFWVGGIASVVTPFFVIVKVFMGTFIWLDLFVSITFVGVGLLLCIVAYYSTKWFK
                     RLCVRYVVWNFKMIKGE"
     gene            17996..18799
                     /locus_tag="CEU84_RS00170"
     CDS             17996..18799
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016512438.1"
                     /locus_tag="CEU84_RS00170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_002014437.1"
                     /transl_table=11
                     /translation="MMKKILLVAIACIIIGVIGISQTYEKAVQTAEKGDKEDVIKNETL
                     KNVEVKLDAGDIVVQKSPDSSFYVKQKGDVSKQEIRIAEDGDTLKIIGEIEKGVSFDFS
                     FYNFGFQTPTLTILVPERSYQEIKVNSSAGQIEISNVKSDRVSVETLAGEVDLKHVTAK
                     SVEGSTKAGEVNFKKVIGKVTAKTASGDIDIIDHDSKYDLEVSSTAGDVDITLLEKPQD
                     AVITGQTAAGDVTIFNEDNKNITIGNGSKKISGKTAAGDVTIETR"
     gene            complement(18903..19517)
                     /gene="lexA"
                     /locus_tag="CEU84_RS00175"
     CDS             complement(18903..19517)
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006282 - regulation of DNA repair
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413738.1"
                     /locus_tag="CEU84_RS00175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_002087894.1"
                     /transl_table=11
                     /translation="MEKLTKRQQDILDFIKLKVQEKGYPPSVREIGQAVGLASSSTVHG
                     HLSRLEEKGYIRRDPTKPRAIEILGDNRTETQSVIQVPIIGKVTAGLPITAVESVEDHF
                     PLPASIVAGADQVFMLRISGDSMIEAGIFDGDLVVVRQQQSAYNGEIVVALTEDNEATV
                     KRFYKEKDHFRLQPENSSLEPIILKQVSVIGKVIGVYRDLH"
     misc_feature    19585..19598
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.42"
                     /tool="antismash"
     gene            19659..20315
                     /locus_tag="CEU84_RS00180"
     CDS             19659..20315
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016111193.1"
                     /locus_tag="CEU84_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_002128580.1"
                     /transl_table=11
                     /translation="MNAIIYARVSTTKEEQETSLLRQKDELLHLAERYQMDVTKVIEEQ
                     ASGYTIERDGILEVLDTIRDEQVDVLLIQDETRLGRGNAKIALMHCLHKEGIKVYTHTH
                     SGELQLSDSDSMVLNIIGIVEEYQRKIHNLKIKRGMQRAVEKGFRPENNLKNRHLSVGR
                     EKKEVPIEEIVRLRRNELTFEEIAATLRGFGHDVSKATVHRRYVEYTKQLLDKED"
     gene            20361..20600
                     /locus_tag="CEU84_RS00185"
     CDS             20361..20600
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172959.1"
                     /locus_tag="CEU84_RS00185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF896 domain-containing protein"
                     /protein_id="WP_002014431.1"
                     /transl_table=11
                     /translation="MPSQELIERINFLAKKAKAEGLTEEEQRERQSLREQYLKGFRQNM
                     LNELKGIKVVNEEGTDVTPAKLKALKKQDNAKLN"
     gene            complement(20641..22224)
                     /locus_tag="CEU84_RS00190"
     CDS             complement(20641..22224)
                     /EC_number="3.1.-.-"
                     /EC_number="3.1.3.5"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199635.1"
                     /locus_tag="CEU84_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="WP_002167808.1"
                     /transl_table=11
                     /translation="MNQNQIVTLNILLTSDVHGTVYPIHYQDNSKAEIGLAKISTLIKK
                     ERSQNANVLLIDNGDFIQGTPFTYHYATYEKDMENPMSLLANYLEYDIAIIGNHEFNYG
                     MDILNNAVATANSPYLSANILDKNRKEPYFGKPYIIKHIESNIKIAILGVTTHYIPHWE
                     QAHHIKDLQFEDAFETTKKWVSYIRKHEKPDLLVVAYHGGFERDLQTGVPTEVLTGENQ
                     GYAMCHEIEGIDILLTGHQHREIAHTVINGVTILQTGCNGHSVGKVTVTFEKAEQKWVK
                     KESYSELLPVQGIAADQDVLSLVANYEEKTQNWLDKPIGIIYGDMQISDAMQTRLQDHP
                     FIEFINKIQMDIANVSISCTSLFHNTSPGFPKHVTMRDIVSNYIYPNTLKVIRITGADI
                     KNALELSASYFTLKADGTIIVNPTYIEPKPQHYNYDMWEGISYVLNISKPIGERVESLQ
                     YKGAPLNMNEEYDVVMNNYRASGGGNFFMFQNKPVVKDIPTDMSELIANYILKHKRIEA
                     TKNENWKVIK"
     misc_feature    complement(22373..22389)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: medium, score: 28.44"
                     /tool="antismash"
     gene            22410..23348
                     /locus_tag="CEU84_RS00195"
     CDS             22410..23348
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000913375.1"
                     /locus_tag="CEU84_RS00195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_002137777.1"
                     /transl_table=11
                     /translation="MLKKVFAMSTTVVLAAGLLSGCGTKESSASKNEDTKKGYVPKTLN
                     VQFVPSQNADTLEAKAKPLEKLLSDKLNIPVKVSISTNYNTIVEAMASKQVDVGFLPPT
                     AYVLAHEKKAANVILQAQRFGVDDETGAPTKDLVDVYKSEFVVKKDSNINSVKDLKGKK
                     IGYQDVTSSAGYVWPAAVLLKEGIDPLKDVKPVTLKGHDQSLIALLNGDVDAAVVFQDA
                     RNIVKKDYPNIFDQTKIVKFTEKIPNDTISVRSDLDAEWSKKLQDAFIEIGKNEEGHKI
                     IKEVYSHEGYVKSDDSKFDIVREYGKKVKTQ"
ORIGIN
        1 tgcaataatt atctccatag atgaaagagc taaggggatg ggcgaaacgt ataatttaaa
       61 tctgattgat agagaagatt taaataatct tgaaaaaatg ataaattcag agtttatcac
      121 ggatgttcaa gtgaattttg atgtagtaaa tcaatggtta aaacagttct ctaattaata
      181 aatgtacttt gataaaaatg gcgatttatt aggaggctca aatgaatagt ataattctcg
      241 ataaaattgt cgtaagaaat aatagagttg attattcttt tagtattaag ggggatttac
      301 aaaagtattt taagacaagt aatcatatgt ttcttgaata taactatgat gtatctgata
      361 tccctttaag tattttggct attccgtttg ttgcaaatgt agttcctctt gtatggatta
      421 ctaattcaac aatagtaata aatgaactag ataaatcttt ttatatttgt ttaaataata
      481 taaaaaatgc atatcaaaac atgtttcctg gtgtgaaatt taaaggatcc gtggatgtag
      541 gagaaattat tgataatgtt tacattccgg aatttgaagc ggcatcttta tttagtgggg
      601 gattagatgc acttactaca tttataagaa taaaagataa aaaacccttg ctagttactg
      661 aatatggatg gcatgaaaat gaaatagagg gtagtaaagt atgggaggca gataaagaaa
      721 atgccataaa ttttgtaaag gataatggac tagaaaatat ttttatacaa tccaactatg
      781 ggacctttat aattgcaggg aacattgacc atgattttag agaaaagtta aacgatacat
      841 ggtggcatgg attgcatcat ggtctagcta taatatctgc agctattcca atagctttta
      901 aacttaagat aaaatgtata tacattgcaa gctctaattc tccattatat caagttactt
      961 gtgcatctga tccaactgtg gataatgaaa taaaatatgc atctggaaca gtatttcatg
     1021 atggatacga acttactagg caagaaaaga ttaaagttgt tgtggaccat tattcagcta
     1081 gtaaagaacc tgttaatatc agggtatgtt ttaaaaatga agaaaattgt tgtaaatgtg
     1141 aaaaatgttt aagaacaatt atgggaatta ttgctgaagg gagagatcct cgtgaatatg
     1201 gttttaatat tccaagtaat ctttatcagt acgttaaaac ttctttaaat agtgaggtga
     1261 agttttttac taatacattc attgaaatgt attggaattt aatccaagtg cgaatgaaac
     1321 aaaattgtga ttgtattaca gataaaaatt tactaaattg gtttctagat tatgatttca
     1381 aggcgcaacg aagaaaagcg ttattaaaat acaggataac aaagtttttc cctattttaa
     1441 agaggaagat tagtgccaaa tttagtagag tgggtacgca aaacaactaa aatatagaag
     1501 gtattacgat gagaatacaa aattccttaa aaaatatttt attcggtttg tctggacaaa
     1561 taattagtat tggcatggga tttgttgttc gaactgtttt tatttataca ctcggtatag
     1621 aatatttagg tgtggatggg ctttttacaa gtatactatt gatgttttcc ctagctaatt
     1681 taggctttga tacagctata atttatagtt tatataggcc attagctgag aaggatatct
     1741 ataaaataca ggcattaatg aatttatatc aaaaagcata cagattaata ggagtagtag
     1801 ttttattatt agggttatct ctattaccat ttcttgatta tttagtgaat gcagatacta
     1861 tgattaaaga cattaacatt atctatcttt tatttttaat aagttcggtg tcatcatatt
     1921 attttgtata taagcaatct attattattg ctgatcaaag taactatatc atttctaaaa
     1981 tacacacttt gttcataatt atatctaacg cattacaaat tgttttatta ataattatta
     2041 gtgattacat tgtagtactg atagttcaat taacattgaa agtaattgag aatgtatata
     2101 ttgcaaataa ggcaaataaa ttatatccat ttttaaaaga aaaaaataat gcgaaattat
     2161 ctaaggcaga cagacgagag ttttttgaga atttgtattc cttgttacta tataaaatta
     2221 gtggtgtagt aattaatgca acagataata taattatatc gaaattcatt ggaattattt
     2281 gggttggtgt gtattcaaat tatttgttga tcttaaatac attaaatacc ttattaggct
     2341 atttgtttta ttctatcact gctagtgttg gaaatttgaa tgtgaaagaa aatgcagaaa
     2401 aaaaatattt tatttttcgt gtaattaact tttttaattt ttggatatat ggattttgta
     2461 cagtttgcct ttggaatttg ataaatccat ttataacact ctggttaggt gaggaatatg
     2521 tgtttaataa gtatgtatta tttttcatat tacttaattt tttcacttca ggaatgcaaa
     2581 atacaactac aatttttaga gaaaccacag gtttatttaa aaaagggaag tatagaccta
     2641 tcatagcggc aattataaat attgtagttt ctataattct cgcgaaacaa ataggaatag
     2701 caggagtgct tttagggact gttattagta gattatgtac ttacttttgg tatgatcctt
     2761 atattatatt taaaatgatt tttaaaaaat ctgtaaaagt atattttatt agatatattt
     2821 tgtttgtagt gcttgtatta ttttctgtta tagcaacgga ttttattggt tatatttttc
     2881 acataaatat atttatggac atggtaatac gtagtatttt gtgcctgatt attccgaatt
     2941 tgatcttttg gatggtattt aaagaggcgg aagagtatag atatttcctt aatttaaccc
     3001 gaatattaat aaaaaaaata aagtcgaaaa tattaactcg gaaagtttcg aatgataatt
     3061 atccataaat tattatttta ttttttccat atcacagtaa agaatgcttt atttacggaa
     3121 gagattttag gttgttctga aaataatagt aggggagtta tgtataaaga gcatagtgtc
     3181 tttttaataa aattgtaagt ttaaatagta taaataaaag ggtattgaaa taaaaacagc
     3241 tagtaagaat agatctattt aggaaggaga aaggaattgt gaaaagactt tctaaataat
     3301 ggatctctaa aaacaataaa aagtgatgtt acttctctta tatccaatca atttacctta
     3361 tgaaacataa gatgtagaaa agcaaaaaag aggtgtgaat tgatgtggag aagaagggat
     3421 aatcttggga atttgaatga tttagatttg gtgtccaagc ctccttttca taatgacatt
     3481 ttaacttatg atagtacgca attaaaatgg attccaaaat catttgaagc tacaaattct
     3541 acaagtatat atgtattaga attagataga tgggatgtta agaatgatgg gactgatgct
     3601 atcaatactt ccaaaggtat taataatgct ttagtttggg cggctcaaca aggttatacg
     3661 gaagttgtgt tacctagagg aatatatttg attgataaac aaacacccat cgaaccacca
     3721 agtcatttaa ctttgaatct aaacggttca acattaaaaa tggaaacaaa taatttgact
     3781 ggatatgcaa ttataagttt tcgtagaaat caagtatatt ctaggataac aaatggtatt
     3841 atccaaggag atagatatac acatgattat tctagtgggg gaacacatga ggcagggtac
     3901 ggcattgaat tggggagttt tactccacct gctgatgggg ggaacaatac acggtttgta
     3961 tctttagata atctagatat tttagattgt acaggagatg ccattacact gaacagtact
     4021 tttgggcaga tttcaccttt tcctacagca ttagcaagtt catttgaaca gggagcaatt
     4081 aatacaacag atggttcatt agtaagtagt acaacaaaga tacgttccaa tttgcaaatt
     4141 gatatgaccc aagtggctat tgtaaagtat ggttactttg gattatatgg aaatggattt
     4201 ggagcattgg gttctgaaat aaaatgcgat tattatgatg tcatttttta cacttcaaat
     4261 aatatatttt tatcttcaaa aaccaatgta caattctttg atgaagtaga agtccctaat
     4321 ggagcaagtt atgctaaaat tgttttgcat caagggaatg ttcctgctcc tgcaaattgt
     4381 ttaataaatg ttcgggtgcc ttctttttca caatatactt atatagaaaa atgtaattta
     4441 catgattgcc gtagacaagg gattagtgta tgtggggcaa agaatgtata tattcgagat
     4501 aatgatattc atcacatcgc aggtaccaat ccacaaagtg gactagatat tgaagatgga
     4561 tatgatttaa atcaatatat atacattgaa agaaataatt ttcatgataa taaaaattat
     4621 aatattattg ttgtaaatgg gaaatttatc tatatatcga ataattctat tatgaatacc
     4681 atttcaaatg cttatgttgg gctatctatt aatggtggtg cagatagggt aatcgtaaca
     4741 gggaataata tccgattaac caaggtctct ttgttaggag atgttatttt ttccaataat
     4801 tatgtatacg gagcgcaagt aaatgttcaa ggtgtatatg taaatcgatc tattaatata
     4861 ttagataata ttttttctaa tagtaaaatg attattgata ccccctttcc atatgcggtt
     4921 aaagttgatt cctgtcgctt tataaacgat gcagataaac taaattcctt gtcatcattg
     4981 tatcagtgga cattagagat gaaaaatgag ccgcaaacta tctcaaattg tatatttgaa
     5041 ggacaagacg ttttgtattt aaattatgta ccagtaggaa cagttaaatc aggatggata
     5101 tttgaaaata ttatatttaa taatgttaaa aacccaacct tagttgcagg gacatataca
     5161 aattgctttt ttaaggacgt aacctttttg gggataacaa gtacaggaag cactttagaa
     5221 ttaaaagatt gcaagttctt tagtatagat agaaataaca cgttatttac agtgaataac
     5281 ctcaaagcat tcaagatgat ggattgtcat atagaaaaac caaatggtac ggtcttgaat
     5341 attcaaaatg tatctgatga aatagtgtta gggggaaata ctataaaaat tacaaatgat
     5401 actcttcaga gagctattat tgttttggat gcagcgttta ctggtaagca agtgataatt
     5461 caaaataata ttataaattc cacaaatttg atgcaagttg ggatagataa tagaacaacg
     5521 agtattacac ccctagtagt aattcaaaac aacgtgttga ataatgcgaa aattacaatt
     5581 acagggaggg aatttctgca agggaatata gttaatggtg taatagatcc aaattaatgc
     5641 atggtgataa ttaaatttga atagtttcaa aaaattatga gaaatgaagt agagtggctc
     5701 ttaataaata tgtccataaa gtattatata atggtacatg gaaggatttt gtccaatgta
     5761 attattcgaa atagtctaat tcctaataga taataggttt attgactttt agttactact
     5821 atagaataga gaaaagctat tatgttttta taaacataat agctttttat tattacgtta
     5881 actgcatact aaaaaatagt gtgtaggaga atttttaaat aataaatgga ttttttaata
     5941 tactactaag cgttgtttat aaaactgtgt ttgtgaatat attttttgag atttttacag
     6001 tgtgtaatag tctcttggat aagcatttgg aaaaatatat tttgcaccta tgtgtattgc
     6061 tttcttctac ttattaagtt ttaaagctgt gtactataga aaatgtttgc aggtgataag
     6121 taaagagaaa ttgaatacaa ttctttaatt acaacttaag aatacttgat ttcaatccgt
     6181 aatgaatact ttgtagatta tttaactttg gaaaagcatt tgtaataatt taagatgggg
     6241 gaatgattgg taatgaagag actgtttgat atctttattt ctttattatt attaatttgc
     6301 ttttttttcg ttattctttt agtagcaatt atagttaaaa ctcagatagg atcacccatt
     6361 ttatttagac aacaacgtcc agggttacat ggaaaacctt tttatcttta taaatttcgt
     6421 acgatgacca atgagcgaga tcgtaatggg gagctgttac aagatcacgc tagattaact
     6481 aaagttggaa aatttcttag aaaatatagt ttagacgaat taccacaatt aataaatgtg
     6541 ctaaaaggtc aattaagttt ggtgggcccc cgcccattat taatagaata tatgccttta
     6601 tattcgaaag agcaagctaa aaggcataat gtaagacccg gaatcactgg atgggctcaa
     6661 gttaatggaa gaaatagtat ctcatgggat gagaaattta aattagatgt atggtatgtt
     6721 gagaatcaaa gttttctttt agatttgaaa attttatatc taacttttag taaggtttta
     6781 aagtcggaag ggataacaaa taataagcat gtgactatgc cagtttttaa ggggggaatc
     6841 gagcatgggg gggaataaaa tgaatatttt gtttactagc tctggtagga gggtcacctt
     6901 aattaaaaaa tttaaggaag tacttaaaca agaaggaatc aaaggaaaaa tctttactgc
     6961 agacttaaaa gaaactgctc ccaccattta ctttagcgat aagcatttta ttgttccgcg
     7021 tgtaaatgaa gagggatata taaatgaatt attaaaaata tgtaaatctg aaatgataaa
     7081 tctaataatt ccgttaattg atacagaatt aacccttatg gctaataatt cgaaggtttt
     7141 cgaaggtatt ggtgtaaaag tattagtttc tagtatggaa ttaaataaga ttgctaataa
     7201 caaaaaatac acatataact tttttgcatc taataatata ccaacaccta gagtatatag
     7261 tgatgaagag attggaagaa aagaatatca atttccacta ttaattaaac cttatgatgg
     7321 cagttctagt aaaggtgtaa caaaaataat gaatgaaaag gaattggaat tttttaagga
     7381 ttatatacct aacgctatga tacaagagta cgtttcagga gaagaataca ctatagatgt
     7441 catggtagat ttctgtggga atataaaaac aatcgttcct agattgcgta tagagacacg
     7501 agcaggtgag gtaagtaaag gtataaccaa gaaggatttt gatatcatcc aagcagcaga
     7561 aactgtaata aaagctcttc ctaatcctat tgggtgtatt actttacaat gttttaaaaa
     7621 ggaggatgga caaattacgt ttattgaaat aaaccctcgt tttggaggag gaataccact
     7681 atcaatagaa gcaggagcga attttccact ttggacaatt aaaatgtgtc agggggaagt
     7741 ctttatagat aaggacttta attggagaga aaatttaaca atgcttagat atgatgaagc
     7801 ggtttttatg gagagtattt aagatgatga ttaaagcaat tgtttttgat atggatgata
     7861 ctttatataa agagaaagat tatgttgtaa gtggttttaa agcagtggat gattggatta
     7921 aagagaagta taagaaaacc ggattttata atattgcaat tcaattattc gattcggggg
     7981 aaagaaggtt cgtgtttaat gaaacactag aaaagttaaa cattccttac gatgaaaaat
     8041 tgattagtaa tttgatagaa cagtataggt ttcataaacc agatattcaa ttgttggatg
     8101 aagcggattg ggtactaaat aatttagtta ataccgttaa aataggactt atttcagacg
     8161 gatatttagt tgcccaagaa aagaaaatta atgcattaaa gttaaaagag agatttcatt
     8221 cgataattct cactgatgag ctgggaaaag aatattggaa gccgagccaa attccttatg
     8281 aaaaaataag taaggaacta caggtgcctc atcagcaatg tgtctatata ggagataatt
     8341 taagtaagga ttttataaca gccaagaaat tgaaatggtt aacgatccat attaatagag
     8401 aaggtggaat tcaccataat cttatagttg agcaagctta taaagcacat tatacaattg
     8461 ataatttaag gagattatct gatatatctg tattagagca tatgttttta gatacatagt
     8521 atttaaatat gtataaagga tgtgtttaca tgcacacagt tcagcataaa aagcgaattt
     8581 acctttcctc tccgcacatg agtaggaatg aacaaaaata tattcaaaat gcatttgata
     8641 caaactggat tgcccctctt ggcccaaatg ttgatggatt tgaaagagaa cttgcatctt
     8701 ttgtaggagt gaaaggtggg gctgcagtta gttcaggtac ggctgctatt catttagctt
     8761 tgcgattatt agatgtccaa aagggagata cagtgttttg ttcaagtttt acttttgtag
     8821 cgagtgcgaa tccgattgtt tatttgggag ctgaaccagt atttattgac tcagaaccgg
     8881 aaacatggaa tatgtcaccg aatgcattgg cacatgcatt gtatgaagct aataaagtgg
     8941 ggaaattacc aaaggctatc attcttgttc atttatatgg tcagagtgct aaactagatg
     9001 aaattctttc actttgtaat caatataatg ttcctatagt tgaggatgca gcagaatctc
     9061 ttggatctac atataaagga aaagcaagcg gtacatttgg gaggtttggg gtttattcat
     9121 ttaacggaaa taaaatcatt acaacttcag gtggtggaat gctagtttct aatgatgtag
     9181 aagcattaga aagagcgagg tttttagcga cacaagcaaa ggatccagct ccacattatg
     9241 agcatagtga gataggttac aattatagaa tgagtaatat attagctggt gttgggagag
     9301 ggcaattaga agtgctagaa gatagagtga ggactagaag gtgtatatat aaacggtatt
     9361 atgaagcact atctcacatg ccaggatttt attttatgcc tgaattagaa aatactcgct
     9421 ctaatcgttg gcttactaca ttgacaattg atgaaaagga atccgggatc tctattggga
     9481 aattgttgag aactttagca gaagagaata ttgaagcgcg tcctatgtgg aagccacttc
     9541 atatgcagtc gctctttaaa gagaagaagt attatccgca tagcaaaaat gaagatgtgt
     9601 cgcagtacct atttcaaagt gggatttgtt tgccttcagg atctaatatg ttagctgaag
     9661 atcaacaaag ggtaattcaa ggtattttaa aagctgtaga atggaagaat taaaagtaag
     9721 taaaagtgga attagatttg tatacgtacc accatttgtt ctttataatg aatttttaag
     9781 gggggtgttt ggggacattc agtttcaatt gacataaaaa agggataatt ataggctttt
     9841 aatatctata tcttagtctg aaagtaaatt taagcatgta attgagaaag taataaaaca
     9901 aataatttcg ttcgttaaaa agaatgataa agaggtatgt ttaacgaatt taatatgtaa
     9961 atagtatttg tagtaacttt tcatatatta ggaggaagaa atgagcgcta tagctggcat
    10021 tatccacttt actaatgagc ctgtatcaat tgagcacgga agagaagtaa tgagtcgttt
    10081 atacaaatat cctgccgatg atattcaaat atggcacaaa gaaaatgctt ttctaggatg
    10141 tcatgcacaa tggattacac cagagtcagt tggtgaacaa ttaccctttt ataattatga
    10201 aaagcaactg gcaattacag cagatgctat tattgataat cgtgatgagt tatttgaaaa
    10261 actacaagtg gattattcgg atagaaaaaa catgacagat agcgagttaa ttttactctc
    10321 ttatcagaaa tggggggaag cggctccaaa atatttggta ggcgattttg cctttatgat
    10381 ttgggatgag aaaaaacaaa ttctttttgg tgccagagat ttttcaggaa gtcggacact
    10441 ttatttttat cgtggtgagg aaaaatttac tttttgtact attataaatc cgttattttc
    10501 tctaccatat gttgagaaga aattgaataa gcagtggatt gctgaatttc tagctatacc
    10561 tgtaaatttc gaatcggtag atccacagtt aacagtttac aaatatatag aacaagtgcc
    10621 tccatcacac actattttgg taaaggaagg cgaagtgaag ttttcgcgat actatacacc
    10681 aactgttggg gaaatgctta atttaaaatc aaatgaagag tatgaagagg cgtttcgaga
    10741 ggtgtatcaa agtgcagtga aggcacgttt acgaacacat caccaagtag gagctcattt
    10801 gagcggaggg ctagactcag gttctgtcgt tagttttgct gcaagtgatt tacgggctga
    10861 aaataaaaaa ttacatacgt acagttatgt tccagtagaa ggatttgaag attggacaca
    10921 caaaggtaga atagctgacg aaagaccatt tattcaatcg actgtcgagc atgtagggaa
    10981 tatacaggat tattatttag aattgccgga gagaagccca ctatcggaaa ttgatgattg
    11041 gctggaaaca atggagatgc catataaatt ttttgagaat actttttggt tgagtggagt
    11101 ttatgaaaaa gcatctcaga atggaatagg agtacttctt agtggtcaaa gaggtaattg
    11161 gacagtatcg tggggaccta ttttagatta ccaggcaatg ttattgaaaa agctacattg
    11221 gattcgtttt tatcgtgaac tacatttata tagtagaaat ataggagtga aaaaatcacg
    11281 tgtttttgaa gtggtaagac gaaaggcatt tccatttttg catcagttac ttttttcagg
    11341 gaaacaagat gcaaattccg caataattaa tccggaattt gcaagggaaa tgaatgtttt
    11401 tgacagactc agagaacaag acatcgatat aacaggcacc tctatctcta atgcatatga
    11461 catgaaaaga gaacagtttg aaaaaccata ttattggagc ataaatggaa cgtatgaaac
    11521 gaaattatca ttacgttatg ctttatggga tcgtgatccc acaaatgact tacgattgat
    11581 tcaattttgt ttgtcagttc cagaagaaca gtatgttcaa aatggtttgg atcgagccct
    11641 gatccggaga gccacaaaga atttccttcc tgataaagta cgattgaatc aacgggttcg
    11701 aggtattcaa ggtgcagatg gtgtttaccg catggctcct ttttggaatg aatttattga
    11761 ggaagttgaa gaacttagtg tagatccagt aatttctgaa tttctaaatg tcgaggtaat
    11821 taagaaagct atctcaaaaa tttgtaaaga acctcgacca gaatatgcat ttgatttaga
    11881 ttttagaatt ttaatgcgta gcttaatctt ctatcgattt ataaaaaaag caatgtgaaa
    11941 ggaggtgata cgtatgaaaa aggaatggaa acaacctgta ttagaagtac ttaatattaa
    12001 tatgactatg gcggggcctg ggcataaata tccagatgct gttcaacctg acccagatga
    12061 tccagtgaag tacagttaag tcattggaaa aataaagctc ttatatagct ttattatata
    12121 agagctttca aaaaattgac aatgtggggg gataggatgt ttgattctat ggggaatgtg
    12181 ttatatcaag ccttcggatt aaaaatagta agtgaaatcc cattacctga attgtctcag
    12241 ctgaatgaaa aaaaagagat ggcggatgtt caagttgaaa taactgattt gtcagaacag
    12301 tggggtgaat atagcgcaga aaagcaaaaa acgatagtag tggaggatga tatagttatg
    12361 tttcatgttc ctcaaactgc aatattcgct atacaatcag gtgagaaaat caccttttca
    12421 cctatggcaa atgcagaaga agataaaatt cgactatata ttttgggaac ttgtatgggg
    12481 gcgcttttaa tgcaacgtaa aatactccca ttgcatggga gtgtaattgc tatagatggg
    12541 aaagcatatg cattaattgg tgattcagga gctggaaaat caacgttagc ctcggctttt
    12601 ttgaataaag gatataagct tttaagtgat gatgtagttg ctgtgtctct tttgaataaa
    12661 aatactgcaa tagttcatcc ttcttacgca caacaaaaat tatggcaaga gagcataaat
    12721 gagttaggaa tggaagtagc gcaatttagc cctttatttg aaagggaaac gaagtatgct
    12781 gttcctgtga attctcaatt ctttcctgat ccattacctc ttgctggtgt tattgaatta
    12841 gtaaaaacgc agggagaaga tatcgagatg acccgtatag aagggctcgc acgcttgtat
    12901 aaattatacc gccatacttt taggaattct ttgatttcta aattaggatt gatggaatgg
    12961 cattttgaaa cttcatctaa tattgcaagt ggaatggaaa tatttcaagt aagccgcccg
    13021 gcttcaagat ttacagctca tgagcttgtg gaagttattt taaatactat acagaaaggg
    13081 agtatggttg atggttgtcc actcgagaaa aatatcatta gaacataacg ttgtccaaag
    13141 taagggtaat atagtaagcg atatggatgg agaaaaagtt atgttaaatg tccagaaagg
    13201 aaattactat aacttaggtg aaataggcgg agaaatatgg gagcttattg aaaagccaat
    13261 aataattaat cagcttgtta ctatgctagt atctaactat gatattgaac gaaaagattg
    13321 tgaagagcaa gttctttcct ttttagagtg tttgtttcaa gaagggttaa ttcaaataaa
    13381 agatcagcct aatagataga ttcgtaattt caaaagaact gttaggaagg gattaataaa
    13441 tattgtgaaa aggttaagga tgtttttatc actaaacatg aaaacaaagc tcttattttt
    13501 agaggctttt atttttttag gatgggcacg tgtactaaaa aatattacat tttccaaagt
    13561 tgcaccttct ttaggggatt acatgagtga aacctcaagt actcatattc aaccgcacgg
    13621 agatacgcta aaaaaggtgt ccgaagcaat ttctattatg agtcgttata ctttttggga
    13681 aagtcaatgt ctcgttaaag ctatagctgg gatgaaaatg ctcgaaaaac gtcacattga
    13741 gagtactctt tatttaggaa ctgctaagga tagtcatggt gaattaattg cgcatgcatg
    13801 gttacggagc ggttcttttt atgttactgg atcagaagga atggagaaat ttactgtcgt
    13861 tggatcattt gcaaagaggt taagtgagga cactattaaa ggagaataaa atggagaaag
    13921 attttggtct taatgtagag ttcatgtcta aggaattgaa acttcttttt acaattttga
    13981 agttacaaga tgacgaaaca ctgcaaactt atagtagtga atggttcaca gatattgatt
    14041 gggaggtttt tcttgagcaa gccatgcatc atcgtgttta tccggtgatt tatcaaaaac
    14101 ttaaacaggt agatgaggaa cgaattcctt cacatgttgt acaaacttta aatagaaaat
    14161 atagaaataa tacatttcaa atgctttatt taagtgctga aatggaacga ataaataaat
    14221 tttttaatga aaatgagatt cgtacgatgt ttctaaaagg acctgtacta tctcaggact
    14281 tatatggaga tatttcttta cgaacatctt gtgatttgga cgttctcatt cctgttcaaa
    14341 aattagaaaa agtagaaaaa ctacttttag agcaaggata tgtgaaagat gattatattc
    14401 aaacgatatt aagtgattgg aaatggaggc atcaccatat aacatttttc catccaacaa
    14461 ggcggatcaa acttgaaatt cattggaggt taaatcctgg accgggtaag gaacctgggt
    14521 ttgaagagct ttggaagcga aagagaaaaa gtgcacttac aagtaattcg gtatatatgt
    14581 taggaaagga agatttattt ttatttcttg tctctcatgg tgctagacat ggttggtcta
    14641 gattgcgctg gttagtggat ataaaaaaaa ttgtcaatca agatcttaac tggagtgaga
    14701 ttaacaaatt aatgagaaaa tatcaaatgt ttcatttagg aggacaagca ttaattttgg
    14761 catctcaaat gttaggtgca cgattagata agaggatgat ggaattagta gcgaaaaaac
    14821 gttcaaagca gttagctcaa gaagcgctgt tttatttcaa gcaaatgata aacttgcata
    14881 ccgatcctgt tcctgaagaa gtacttgctt atcatagtag gcatttattt tcactgatgt
    14941 ctaatcagca aaaaatttta tttattatga gccaactcta tccttatccg attgatgcaa
    15001 aaacattgcc gttacctaaa ttccttcatt ttttatattt tcctttacgt ccgtttctat
    15061 gtctttggag gaaaacaaag aagcttgctt tgtcataggg ggaacatcga tgaatcatat
    15121 tatatatttt atgaagaaat tatattcttc tgcagggaaa attctgtatg tgaatttgtt
    15181 tggtatggtt ttaataagtt tacttgaagg gataggtatt attttattaa ttcctatgat
    15241 aagtatggct ggaataatta atataggtga ggagactgct tttattgcac ctgtttatag
    15301 atttttgcag gatttcccta aaacaacaag cctaatttct attttaggta tatatatact
    15361 aatagtgtta gggcaaaatc tattacaacg aaacataacg ctaagggatg cgagaacgca
    15421 acaagctttt gtacgagaat taagaataga aacatatagt atgattctaa aagcgaagtg
    15481 gagttttttt ttagagaaaa ggaaaacaaa tctaataaat atattaacta cagaattagc
    15541 tcgcgtaagt tatggggtta atttaatttt acaattgtta gctgttattc tgtttacatt
    15601 catacaggtg gggcttgcgt ttttattatc tccccaaata actatatttg ttttggtctt
    15661 tggcttatta ttcttagtag cttctcgtgc ttttataaaa aaagcacgaa tactaggcgg
    15721 taagacctcg aaattagcac aagactatct ttctggtata acagatcatt ttaatggaat
    15781 taaagatata aagagtaata ctttggaagc atcacgttta gattggttac aatctataac
    15841 agaaaagatg agtaatgaac aaatggagta tatgagaata aggtcgaact ctcaattgtt
    15901 ttataaagtt tcaatggcta ttttaattgc attttttata ttattatcag taagtatatt
    15961 taaagctcaa cccacccaat tactattaat catactcatc ttttcgagac tatggccacg
    16021 atttatgaca attcagtcaa atttagaaca gcttgctgca agcattcctg cttttaagtc
    16081 attatgggaa ttacaagggg aatgtaatga agcaattgaa atgcaggata tacatcagca
    16141 aaaacatata aagccgattt gtatagagca gggtattgaa tgtaagggta tttattttcg
    16201 atataataag aaggagcatt tgtatgcact tcaaaatatt aatgtgaaaa taccaatcaa
    16261 tagtatgacg gctattgtgg gacattcggg agctgggaag agtacattaa tcgatgtttt
    16321 aatgggattg attcagccag agaaaggtca agtattaata gatggaactc ctcttacaag
    16381 tgaaaagtta ttgtcattga gacgggctat tagttatgtg ccacaagatc cttttttatt
    16441 taatgcaagc ataagagaaa atttattgat gattgagccg aatgcgagtg aagaacaaat
    16501 ttggactgca ttagattttg cggcggcagc tgaatttgta cgaatgcttc caaaagggct
    16561 tgatactctc attggagatc gtggagtgag actttcaggt ggtgaacgtc aacgacttgt
    16621 actagctcga gctattttaa gacaaccatc cattttagta ttagatgaag ctacgagtgc
    16681 attagatact gaaaatgaag taaaaattca atcagcaata gaaaggttga aaggaacgat
    16741 gacaattgtt gttattgcgc atcggttatc tacgatccgc aatgcagatc aagttattgt
    16801 tttaggaaaa ggtgagattg ttcaaaaagg tgaatttaat caattggcta aagagagaaa
    16861 aggtgtattt cgaaatttat tagggtcaca aatggaagtg ggttcataga ggagaaagat
    16921 tgaatgaaat cttgtagtat tgtaattcga gttgaatgaa agccgggata atggtcagtt
    16981 acaacagatc ttattcgggc ttttatattt gtgttttcta aatttaggga ataaatataa
    17041 ttcagtacct tgcaataaac aatactaagt ggtatattat ggataaaata gctaccgttt
    17101 attgaacagt actaaaatga gaaaggggga ttgtccttga acgttcagtt taaaaaaggt
    17161 gtgttagaac tgtgtgtatt ggcacttgta aaacgtaagg attgttatgg atatgaactt
    17221 gttcagcaaa tctctaataa atttttaata tcggaaggtt ctgtatatcc gttattacgt
    17281 cgtttaacga aagagggata ttttcaaacg tatttaaaag aatccacgga aggaccgccc
    17341 cgtaaatatt atcaactaac agagcaagga gagatgcaac ttactttatt agtaacagag
    17401 tggcgtgatt ttgctaaagg tgttcaagaa attattgaag gggtggaatg ggatgagtaa
    17461 agagcagttt cttaaagaat tatcaagtca tcttagaaag ttaccagaag aagagcgaca
    17521 agatatttta tttgattatg aagagcactt tcagtttggg atggaagagg ggaaaactga
    17581 atcagaaata ataaagggac ttggctctcc gaaagtaatt gcgaaagact tacttgcgat
    17641 gtatcgattt gatgaaatga aaaaagatcc gtcgacttca aatgtgacaa gagctgtcat
    17701 ggcagcggtt ggacttagtt tgtttaattt tattattgtg ttaggcccgt tagttgcaat
    17761 tatagctttt atattttcct tttgggtcgg tgggattgct agtgtagtga caccattttt
    17821 cgttattgta aaagtattta tgggcacttt tatatggttg gatcttttcg ttagtataac
    17881 gtttgtcgga gtaggtttgt tgttatgtat tgtagcttat tatagtacga agtggtttaa
    17941 aagattatgt gtacgctatg tagtctggaa cttcaaaatg ataaaagggg agtagatgat
    18001 gaaaaagata ttattagtag ctatcgcttg tatcattatt ggagtaatag ggatttcaca
    18061 aacatatgaa aaagcagtac aaactgcaga gaaaggagat aaagaggacg taattaaaaa
    18121 cgaaacgcta aaaaatgtag aagttaagtt agatgctgga gatattgttg tccaaaaatc
    18181 tcctgattcc tctttttatg taaagcaaaa aggagacgta agtaaacagg agattcgtat
    18241 tgctgaagat ggtgatacat taaaaatcat aggggaaata gaaaaaggtg tttcatttga
    18301 tttttcattt tacaatttcg gatttcaaac gcctacattg actatattag tacctgaacg
    18361 ttcttatcaa gagataaaag taaattcatc cgctggacaa atagaaataa gtaatgtgaa
    18421 aagtgaccgc gtaagcgttg aaacactcgc cggagaagtg gatttgaaac atgtaacagc
    18481 gaagagtgtg gaggggtcta caaaagctgg tgaggtgaat tttaaaaaag taatagggaa
    18541 agtaacagca aaaacggcta gtggggatat agatattatt gatcatgatt ctaaatatga
    18601 tttagaggta agttcaactg ctggagatgt agatattact ttattggaaa aaccacaaga
    18661 tgcagttata actgggcaaa ctgctgctgg agacgtgaca atttttaatg aagacaataa
    18721 aaatataacg attggtaatg gtagtaaaaa gattagcggt aaaaccgctg ctggagatgt
    18781 tactattgaa acgcgttaat aattaatgaa acgcattctt ttgaatgaac ggaaatctat
    18841 caaaatataa aaagaagata attacctata taaataaggg aattatcttc tttttattat
    18901 ttttaatgta aatcacgata tacgccaatt acttttccaa taactgacac ttgttttaaa
    18961 ataataggtt ctagtgaaga gttttccggt tgtagacgga aatgatcttt ttctttatag
    19021 aaacgtttaa cagttgcttc gttatcttct gttaaagcaa ctacaatttc accgttgtat
    19081 gcagactgtt gttggcgaac aacaactaaa tcaccatcaa agataccggc ttcaatcatg
    19141 ctatctccag aaatgcgtaa cataaacact tgatctgctc cagcaacgat actagctgga
    19201 agtgggaagt gatcttctac actttcgact gctgtaatcg gtaaaccggc agtaactttt
    19261 ccgatgattg gaacttgaat aacagattgt gtttccgttc ggttgtcacc taaaatttca
    19321 attgcgcgtg gttttgttgg atcgcgtcga atatatccct tttcttctag tcgtgataaa
    19381 tgtccgtgca ctgtagaact agaagcaagg ccgactgctt gaccgatttc acgtacggaa
    19441 ggtggatatc ctttttcttg tacttttagc ttaataaagt cgagaatgtc ttgctggcgt
    19501 ttcgttaact tttccatgtt ttctaacacc tcgttttctt tcatttttct tattattaag
    19561 tataacatgc gaaaaaacat tctacaaaca taagttcgaa cgaaaggcaa atttatgata
    19621 cactataagg aaaatatagt gagaaagaag ggttcaaaat gaatgcaatt atttatgcac
    19681 gtgtgagcac aacaaaagaa gaacaggaaa catcattatt gcgtcaaaaa gatgaattat
    19741 tgcatttagc tgagcgctat caaatggatg ttacaaaggt aattgaggag caggctagcg
    19801 gttatacaat tgaacgtgat ggcatattag aagtgctaga tacaattcga gatgaacaag
    19861 ttgatgtact acttatacaa gatgaaacgc gtcttggtag aggaaatgca aagattgcat
    19921 taatgcattg tttacataaa gaggggataa aagtttatac gcacacgcat agtggtgaat
    19981 tacagctttc agattctgat tcgatggtgc taaatataat tgggatcgtt gaagagtatc
    20041 aaagaaagat ccacaattta aaaattaaac gtggcatgca aagagcagtg gagaaaggat
    20101 ttcgtccaga aaataatttg aaaaatcgtc atttaagcgt aggacgtgag aaaaaagaag
    20161 tgccaattga ggaaattgta cgtttgcgcc ggaatgaatt aacttttgaa gaaattgcag
    20221 caacacttcg tggttttggt catgatgttt caaaagcaac tgtacatcga aggtatgtag
    20281 aatatacaaa gcaattgctt gataaagagg actaactatt gtatgataat aatcagtttt
    20341 gagtagaagg gggattcgag atgccaagtc aagaactcat tgaacgcatt aacttcttag
    20401 cgaaaaaagc aaaagctgaa ggcttaactg aagaagaaca acgtgagcgc caatcgcttc
    20461 gtgaacaata tttaaaagga tttcgtcaaa atatgttaaa cgaattaaaa ggaattaaag
    20521 tcgttaacga agaaggcacg gacgttacac cggcgaaatt aaaagcttta aaaaagcagg
    20581 ataatgcaaa attaaattaa aagatgggca tagcccatct ttttttattt gttaaaattg
    20641 ttatttaata actttccagt tttcattttt cgttgcttct atccttttat gcttcaatat
    20701 atagttagcg ataagttcag acatatctgt tggtatgtct tttactactg gtttattttg
    20761 aaacataaag aagttcccgc caccgcttgc acgataatta ttcataacaa cgtcatattc
    20821 ttcattcata ttaagaggag cgcctttata ctgcaaagac tctactctct ctccaattgg
    20881 ttttgaaatg tttaatacat acgaaatccc ttcccacata tcgtaattat agtgttgtgg
    20941 ttttggttct atataggtag ggtttacgat gatggttcca tctgctttta atgtgaaata
    21001 agaagcagag agttcgagag cattttttat atccgctccg gttattctaa ttacttttaa
    21061 tgtatttgga taaatataat tagaaacgat gtcacgcatt gttacatgtt tagggaaacc
    21121 tggagatgta ttatgaaaca aacttgtaca agaaattgaa acattagcta tatccatctg
    21181 tattttattt atgaattcaa taaaaggatg gtcttgcaaa cgtgtttgca tagcatcgga
    21241 aatttgcata tccccataaa ttattccaat aggtttatca agccaatttt gtgttttctc
    21301 ttcataattg gcaaccaagg aaagaacatc ttggtctgcc gcaattcctt gtacgggcaa
    21361 taactctgaa taactctctt ttttcaccca tttttgttct gctttttcga atgttactgt
    21421 tacttttcca actgagtgtc cattgcatcc ggtctgtaaa attgttacac cattaatcac
    21481 ggtgtgagcg atttctcggt gttggtggcc tgttagtaaa atatctatgc cttcaatttc
    21541 atggcacatt gcatatcctt ggttttcacc tgttaaaact tcagtcggta ctccggtttg
    21601 taaatcacgt tcaaatcccc cgtgataggc tacgactagt aaatctggtt tttcatgttt
    21661 acggatgtaa gaaacccatt tttttgttgt ttcaaatgca tcttcaaatt gtaaatcttt
    21721 aatatgatgt gcttgttccc aatgggggat gtaatgcgtt gtcaccccta aaatagcaat
    21781 ttttatgttt gattcaatat gttttattat atatggtttt ccgaaataag gttcttttct
    21841 gtttttatct aaaatgtttg ctgatagata aggggaattt gcagtagcca cagcattatt
    21901 taatatatcc attccgtaat taaattcatg atttccgata attgcaatgt catactctaa
    21961 gtagttggct aataaggaca ttgggttttc catatctttt tcgtatgtag cgtaatgata
    22021 agtaaatggt gttccttgaa tgaagtcccc gttatcaatc agaagaacgt ttgcattttg
    22081 agaacgttct ttttttatga gagtagaaat tttagctaaa ccaatttctg ctttggagtt
    22141 atcttggtag tgaattggat acacagtacc atgtacatcg cttgttaata aaatatttaa
    22201 agttacaatt tgattttgat tcaacgccat tcaccttttc tatagttatc tttcaattaa
    22261 tcatatcaaa tatatgaaaa gaattttaat gtgaatgtat agaatgtgta aagattctgt
    22321 aaataagcaa ttatttgtaa aaatatgtga tatatttctt catgtttatg gaaggttatt
    22381 ttataacaac gaaaaatgga ggcattaaca tgttgaaaaa agtttttgca atgagcacaa
    22441 cagttgtact agcagcggga ttattaagtg gatgtggaac gaaggaatca agtgcaagta
    22501 aaaatgaaga tacgaaaaaa ggttatgtac cgaagacact aaatgttcaa tttgttcctt
    22561 ctcaaaatgc agatacgtta gaggcgaagg caaaaccatt ggaaaagcta ttaagtgata
    22621 aattaaacat tccggtaaaa gttagtattt caacgaatta caatacaatt gtagaagcga
    22681 tggcatctaa gcaagtagat gtaggctttt tacctccaac agcgtatgtg ttagcgcatg
    22741 agaaaaaggc tgcaaacgta attttacagg cgcaacgttt tggggtagat gatgaaactg
    22801 gagctcccac aaaggattta gtagatgttt ataaatcaga gtttgttgtt aagaaagatt
    22861 ctaatattaa tagtgtaaaa gatttaaaag gtaaaaaaat tggctatcaa gatgtaacat
    22921 catcagcggg ttatgtatgg cctgcggctg tattgttaaa agagggaatc gatccgttga
    22981 aagatgtgaa acctgttaca ttaaaaggtc atgatcagtc acttattgct cttttaaatg
    23041 gtgatgtaga tgcagctgtt gtattccaag atgctcgtaa tattgtaaaa aaagattatc
    23101 cgaatatatt cgatcaaacg aaaatagtaa aatttacgga gaaaattcca aacgatacga
    23161 tttctgtacg ttctgattta gatgcagagt ggagcaagaa attacaggat gctttcattg
    23221 aaataggaaa gaatgaggaa gggcacaaaa tcattaaaga agtatactca catgaaggat
    23281 acgttaaatc tgatgatagt aaatttgata tcgttcgtga atatggaaag aaagtgaaaa
    23341 cgcaataata catatggaaa tggcgactaa ctggaaagtg tgtgatttca gttagtttgc
    23401 cgtttttcag ttattgataa tacatagaag gtaggtaaga tgtgtgatag agtttcgaaa
    23461 tgtttccaaa gtgtatccga atggtacaaa aggattgaat aatataaact tgaaaattca
    23521 aaaaggtgag tttgttgtaa tggtcgggct atccggtgct ggaaaatcaa cacttcttag
    23581 atcggtaaat cgccttcatg aaatcacaga aggagaaatc attattgaag gggagtctat
    23641 tactgctgca aaaggaaaag gattacgacg catgcgccga gatattggta tgatttttca
    23701 aagctttaac cttgtgaagc gatcaacggt actgaagaat gtattagctg ggcgggttgg
    23761 atatcattct acattgcgta caacgttagg tctgtttccg aaagaggatg tggagcttgc
    23821 attccaggcg ctgaatagag tgaatatctc agaaaaagca tatgcacgag ctgatgaatt
    23881 atcaggggga caacagcaac gtgtatcaa
//
