LOCUS       NZ_CP021744            22919 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces albireticuli strain MDJK11 chromosome, complete genome.
ACCESSION   NZ_CP021744
VERSION     NZ_CP021744.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces albireticuli
  ORGANISM  Streptomyces albireticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Streptomyces albireticuli Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2017) Department of Mcrobiology, Shandong
            Agricultural University, No.61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 2.3
            Expected Final Version            :: yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 07:12:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,975
            CDSs (total)                      :: 6,876
            Genes (coding)                    :: 6,711
            CDSs (with protein)               :: 6,711
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 165
            CDSs (without protein)            :: 165
            Pseudo Genes (ambiguous residues) :: 0 of 165
            Pseudo Genes (frameshifted)       :: 74 of 165
            Pseudo Genes (incomplete)         :: 97 of 165
            Pseudo Genes (internal stop)      :: 5 of 165
            Pseudo Genes (multiple problems)  :: 9 of 165
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:17:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5422834
            Orig. end                         :: 5445753
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021744.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22919
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="25"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22919
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22919
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12919](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12919
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(103..117)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.85"
                     /tool="antismash"
     misc_feature    complement(104..117)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            complement(367..1227)
                     /locus_tag="SMD11_RS23465"
                     /old_locus_tag="SMD11_4758"
     CDS             complement(367..1227)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180135.1"
                     /locus_tag="SMD11_RS23465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4758"
                     /product="ECF transporter S component"
                     /protein_id="WP_087928311.1"
                     /transl_table=11
                     /translation="MTEHGEVREAGGEVKVSADRQARAVRLGPRSVAALVLVSAMGVAA
                     FGWPLLADASSGLAHSKDAPWLFAALLPMLLAVVVATISDTGLDAKAVAMLGVLAAAGA
                     ALRPLGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGSVSMFASALLTGGVGPWMPFQMLA
                     MGWVAMGAGLLPGPDRLRGARELVLLAGYGAVASLFYGTVMNLQGWPYIGALATGVSFV
                     PGDPLPENLGRFVAYCLATSLGWDLPRAVVTVVATLTLGPAVLKALRRATRRAAFDAPV
                     AFRDA"
     gene            complement(1224..2918)
                     /locus_tag="SMD11_RS23470"
                     /old_locus_tag="SMD11_4759"
     CDS             complement(1224..2918)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984203.1"
                     /locus_tag="SMD11_RS23470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4759"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087928312.1"
                     /transl_table=11
                     /translation="MIRFEQVSVSYDGAGAPALRGVDLTVPEGELCLLVGPSGVGKSTL
                     LGTVSGLVPHFTGGTLHGRVTVAGRDTRTHRPRELADVVGTVGQDPLAHFVTDIVEDEL
                     AYGMESLGLAPGVMRRRVEETLDLLGLAALRDRPIATLSGGQQQRVAIGSVLTTHPRVL
                     VLDEPTSALDPGAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADQVLLLPAPGAAP
                     VLGDPAALMAVSPVQPPVVALGRLAGWSPLPLSVRDARRRAAPLRERLAPLAPPAGPDA
                     SRDGAAGPAGRPAAPRPRGGFLRRSPRPASGGPAEVTGLAVRHGRVVALRDIGLSVRAG
                     ETVALMGRNGAGKSTLLRTLVGMHRPAAGTVRVGGVTPGDTAPAELLRHVGLVPQEPRD
                     LLCADTVAAECAAADGDAGAAPGTCRTLVSELLPDVADATHPRDLSEGQRLALALAIVL
                     TARPPLILLDEPTRGLDYAAKARLVEILRGLAAGGHAIVLATHDVELAAELAHRVVVIA
                     DGEVVADGPTAEVVVASPAFAPQVAKVLAPLPWLTVPQVRRSLEATA"
     gene            complement(2915..4441)
                     /locus_tag="SMD11_RS23475"
                     /old_locus_tag="SMD11_4760"
     CDS             complement(2915..4441)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539164.1"
                     /locus_tag="SMD11_RS23475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4760"
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="WP_234366143.1"
                     /transl_table=11
                     /translation="MSGRTPPRRGGDRAAAPAAAPLTGRASALHAGAWWVWALGLATAA
                     SRTTNPLLLGLLIGVAGYVVAARRTDAPWARSYGAFLKIGLFVIGIRLVFAVVLGSPIP
                     GTHTLVTLPEVPLPDWAKGVRIGGRVTAEGLLFAFYDGLKLATLLICVGAANALANPAR
                     LLKSLPGALYEAGVAIVVAMTFAPNLVADVQRLRAARRLRGRPDHGLKALLQVGLPVLE
                     GALERSVALAAAMDARGYGRTARVPRAVRLTTNVLTLGGLLGVCAGTYGLLADEGAGYG
                     LPLLLAGLAAALAGLWLGGRRSVRTRYRPDRWGTRAWLVSGSGAAVAALMIWANGYAPA
                     ALHPPAVPLTAPDLPLWPAVSVLLGLLPAVVAPAPVRATAGPSTGPDGPSGRARRPVAS
                     SRGRAAHVTGTRADAAAHRRNPAEGPVTDPAGSAAPVGRTDSPPAPEGRTEGARSTPGA
                     GPRDTAAAGVPTGPRPTGRPATATGDGDAAAPAAPTTPPGREPGRKEAPQ"
     gene            complement(4438..5130)
                     /locus_tag="SMD11_RS23480"
                     /old_locus_tag="SMD11_4761"
     CDS             complement(4438..5130)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004931782.1"
                     /locus_tag="SMD11_RS23480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4761"
                     /product="SCO2322 family protein"
                     /protein_id="WP_087928313.1"
                     /transl_table=11
                     /translation="MTRGRGARALGTLLLAGLLAALGAAPAQAAGYRYWSFWESSGDGW
                     AYATQGPSTARPGDGSVIGFRFAVSEDSKDAAKPRAEADFDAVCEDTPEKDGGKRVAVV
                     VDFGTPADAPGGETPPAQRTACAQVTKDASAGEALAAAAKPLRYDSSALLCGIAGYPRS
                     GCGEQVGAGEPKKEKGSSTPASPGATENAGDSGGDGDGGPSAGLIGGVAAVVVLGAAAV
                     WQARRRRG"
     gene            complement(5127..6395)
                     /locus_tag="SMD11_RS23485"
                     /old_locus_tag="SMD11_4762"
     CDS             complement(5127..6395)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060238.1"
                     /locus_tag="SMD11_RS23485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4762"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_087928314.1"
                     /transl_table=11
                     /translation="MAPSLAVPARRGAAALAAAAVLSAAMAPAAFADASPSPKSGLYGT
                     TDPKFDGVFRQSLAFVAQDAVGVRPAKSAVDWLTGQQCADGAFPGYRADTSKACDPQKE
                     EFTDATAAAVQGLVAAGGQGDAVKKGLDWLKAHQNADGGWGYQAGSPSDANSTSIAVGA
                     FAAAGQDAAKAAVKDGKNPVDALLTFQLGCDAKEEERGAFSYLKDKDGLRADNLASAAA
                     GLATRGKGFLVDPVKKDADAPVKPLSCEGDDSARPKDAAAAAEAVDGYLTAVLDKNGGY
                     LLPSMPGAPAKPDQGNTADAVIALAAGGHRTAAEKPLKWLASKESGTAAWADKNPGKLA
                     KLVLAAHAAGADPRSFGGADLVAQLNATGPAPEAAESAGEKKDDEKKDDDGGFGTWWIV
                     GIFFVASVGAGFLISGRKKKQQL"
     regulatory      complement(6603..6724)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    6689..6701
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.54"
                     /tool="antismash"
     gene            complement(6732..7769)
                     /locus_tag="SMD11_RS23490"
                     /old_locus_tag="SMD11_4763"
     CDS             complement(6732..7769)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605915.1"
                     /locus_tag="SMD11_RS23490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4763"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_234366144.1"
                     /transl_table=11
                     /translation="MTDHGGGVWSVPVPIPGNPLGHTLVHLLDTGRGPVLVDTGWDDPA
                     SWDALTAGLAACGTSVAALHGVLVTHHHPDHHGLSGRVREASGAWIAMHPADTELVRHL
                     RGTPPGGWIDLLAGKLTAAGAPAGHVARLEAARAAARELPGRRAALPDRELVHGELLDL
                     PGRRLRAVWTPGHTPGHVCLHLEEAHPHGGAGNGRLFSGDHLLPGITPHVGLYEIYEPA
                     RAPGEGPADPLGDYLSSLARVAALDPAEVLPAHQHAFTDAPGRVRELLAHHRARLAELR
                     ALLGTPRTLWQLTASMAWNRPWDRIPYASRNIAVAEAEAHLRHLVARRQAEAVPGSHPV
                     AYVAV"
     misc_feature    7920..7935
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    7920..7938
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 19.93"
                     /tool="antismash"
     misc_feature    7923..7936
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.97"
                     /tool="antismash"
     misc_feature    complement(7923..7938)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.33"
                     /tool="antismash"
     gene            8033..9493
                     /locus_tag="SMD11_RS23495"
                     /old_locus_tag="SMD11_4764"
     CDS             8033..9493
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381665.1"
                     /locus_tag="SMD11_RS23495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4764"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_087928316.1"
                     /sec_met_domain="Aldedh (E-value: 7.7e-152, bitscore:
                     504.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELIEYGQLFIGGAMTDPAGRDTIDVVSPHTERVIGRVPHAGFE
                     DVDRAVAAARASFDSGVWAGLPLAGRIEVVTRIKDGIAARHEELARTISAENGSPYSWS
                     VLAQALGAMMVWDCAIGVARDIPYEERRGGVLGPLVVRREPVGVVAAVVPWNVPQFVAA
                     AKLAPALLAGCSVILKPSPETPLDAYLLAEIVAAAGLPEGVLSILPAGPETGEYLVGHP
                     GVDKVSFTGSVAAGKRVMEVASRHLTRVTLELGGKSAAVVLPDADLDAAVAGIVPSAWM
                     NNGQACVAQTRILAPRVHYDELAERFAAAARALVVGDPLDPATQVGPLVAERQRRRSLD
                     YIALGRREGAKVLAGGGRPAGLDTGWYVEPTLFGDVGNTMRIAREEIFGPVICLLPYDT
                     EEEAVRIADDSDYGLSGSVWTRDVEHGLDIARRVRTGTYSVNTFSLDMLGPFGGYKNSG
                     LGREFGPEGFAEYQEHKMIHLPAGHGEG"
     gene            9493..9726
                     /locus_tag="SMD11_RS23500"
                     /old_locus_tag="SMD11_4765"
     CDS             9493..9726
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957280.1"
                     /locus_tag="SMD11_RS23500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4765"
                     /product="ferredoxin"
                     /protein_id="WP_087928317.1"
                     /transl_table=11
                     /translation="MAERWRVTVDRRVCVGSGLCAGLAPEAFRLDPARRSHPVPGARGE
                     SERVREAAEMCPVEAIAIALADTGEAVFPPPE"
     misc_feature    9899..9916
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.22"
                     /tool="antismash"
     gene            10001..12919
                     /gene="lanKC"
                     /locus_tag="SMD11_RS23505"
                     /old_locus_tag="SMD11_4766"
     CDS             10001..12919
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983511.1"
                     /locus_tag="SMD11_RS23505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4766"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_087928318.1"
                     /sec_met_domain="micKC (E-value: 5.8e-143, bitscore: 476.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.2e-10, bitscore: 39.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.9e-09, bitscore:
                     33.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYEVYCLADRHFYETPDRLSLPAGGAPEAGGGFYETARRPVP
                     AGWHTSRTGDWLHLTPVDADGAPRPGQPPQGWKIHVSATAASAEKTAAAVWDHCVPRGI
                     PFKFVPAPHLLHLRNSKYAGRDHSGKFVTVYPKDEEQLHATLTELHEVVGGRPGPYVLT
                     DLRWHDGPLYVRYGAFARRFCVDARGTLVPAIEDGEGRLVPDRRDPAFHVPDWVTLPAF
                     LEPHLAARNATTVGELPYRIEKALHFSNGGGVYAGTDTRDGRKVVLKEARPHAGLAADG
                     ADAVARLERERAALEKLSGLGVAPEVRDWFTLGEHSFLVMDFVEGRLLNSYFSERHPLI
                     AATPATTAVADYTAWALRVHAAVEEAVALVHSRGVVFNDLHMFNIMVAPDERSVTLIDF
                     EAAAPAAEHGRQIVAHPGFVAPPDRTGTEVDRYALACLRLALFLPVTMLFAIDRGKAAH
                     LAEVIAEEFPEVPEEFLAEAVAEIAGEGAGGRAAGGGPGRGAHDGAGGRAGSGAAGGSG
                     SGVHGDVRTAGGRGAPGGTRSGTGGGAVGGSGSDPGRGVHAGTATRRGADGRAGSAAVP
                     AAARRPRAGAHPAPGDWPRSRDSMARAILASATPDRADRLFPGDIAQFGDGGGLGLAHG
                     AAGVLHALAETGADRYERGERWLLDHTDPLPPGTPLGLYDGVAGVACVLDRLGHTRRAL
                     DLAATVLAEKWQRLTSDLHSGLAGVGLALDHLARTTGERQLHDQAVEAAQLLADRLAAD
                     LASPAAGRRRAGLMHGASGPALLFLRLHERTGAPALLELAERALRADLARCVTTPNGTL
                     EVDEGWRTMPYLGDGSVGVGMVLDDFLDRAARRGTAADPALAEARTGILRAARSRFYVQ
                     PGLLQGRAGMVLHLGRTTAPGVTAEHLATQVRGLSWYAMAYEGELAFPGSQMMRLSMDL
                     ATGTAGVLLALGAALGAPGGPAPQLPFLPPLRAPKDRLRTEP"
     gene            12952..13074
                     /locus_tag="SMD11_RS23510"
                     /old_locus_tag="SMD11_4767"
     CDS             12952..13074
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="SMD11_RS23510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4767"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_087928319.1"
                     /transl_table=11
                     /translation="MALLDLQNMDSEEYGGGHGGGGSNVSLLLCWSTASVALCL"
     CDS_motif       12952..13008
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQNMDSEEYGGGHG"
                     /locus_tag="SMD11_RS23510_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13009..13074
                     /prepeptide="core"
                     /locus_tag="SMD11_RS23510_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="13.20"
                     /molecular_weight="1961.3"
                     /monoisotopic_mass="1960.0"
                     /core_sequence="GGGSNVSLLLCWSTASVALCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQNMDSEEYGGGHG"
                     /leader_location="[12951:13008](+)"
                     /alternative_weights="1979.3"
                     /alternative_weights="1997.3"
                     /alternative_weights="2015.3"
     misc_feature    12964..12978
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.65"
                     /tool="antismash"
     gene            13222..14949
                     /locus_tag="SMD11_RS23515"
                     /old_locus_tag="SMD11_4768"
     CDS             13222..14949
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180166.1"
                     /locus_tag="SMD11_RS23515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4768"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087928320.1"
                     /transl_table=11
                     /translation="MAQTSTAPAGAPGERHPGDRILLDATRHSAARAAALALIAVAATG
                     ATLLLPAALGHTLDLLLARRGAEATRWVLLCAGLVCAPAALDALDEVLSGTTAARTTAW
                     LRHRLLAHVLAAGPRATARFAPGDLVTRLVGNAADVGTAPGTLAGSAAAVAAPLGGVLA
                     LGLIDPWLAVGFLAGAPLLALLLRAFARASGDCAAEYQRLQGEIAGRLVEAVGGARTIA
                     AAGTARRETARVLAPLPGLSHQGHRMWRVQGRAAAQAVTVVPLLQITVLAVAGLRLTQG
                     ALSVGDLLAASRYAVLATGVGVLVGHVSAIVRARTAAGRVAEVLAEPATAHGYCQLPAA
                     GAGTLELRGVSAERGGRTVLRDVDLVVPGGTSLAVVGRSGTGKSVLAELAGRLADPAAG
                     VVTLDGVPLRELGHDTLRRAVGYAFARPAPLGGTIGGTIAFGVFDPGPDAVTEAARAAC
                     ADGFVRRMPLGYATPCEDAPLSGGESQRLGLARAFAHAGRVLILDDATSSLDTLTEHEV
                     TRALHGTTTRTRLVVAHRASTAARADRVAWLADGRLRATGTHEDLWRDPEYRALFGAR"
     gene            15157..17043
                     /locus_tag="SMD11_RS23520"
                     /old_locus_tag="SMD11_4769"
     CDS             15157..17043
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128987.1"
                     /locus_tag="SMD11_RS23520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4769"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_234366145.1"
                     /transl_table=11
                     /translation="MPERRRGGGRDDGGGVARRGLRFLRRRRAVVAWLAVWSVVEAAHT
                     FGLGYALARALDSGFLAGRAGVGLGWLGAAAGAVVVGAYGTGRTYGGVAGLVEPLRDGL
                     VRRVVPAALRDADGAAVSRLTHQVEIARDAFAGLVMVSRSFVFTAAGALTGLFLLSPAL
                     LVVVVPPLALGLGLFLATLRPLARRQEAFLIADEAVARSFGEVSAGLRDITAGGAERRV
                     REGTGALVDAERRASAALARWSVVRVVALAVAGQVPVVLLLAATPWLLDRSVTPGALVG
                     ALAYLTQSLLPALQNLVHGLGGSGSRLAVVLRRLTAGPPPAPAARPTGGHPAAAPTTPA
                     VELRGVTFAYGEHADPVVDGLDLAVPAGSHLAVVGPSGVGKSTLAGLMAGLLVPRSGEV
                     RIGGRPPGDPAGRVLIPQEAYVFSGTLGDNLRYLRADPVTERELTEAAEALGMSGLVAR
                     LGGFGARLAPDALSAGERQQIALARAYLSPAPVALLDEATCHLDPAAEARAERAFARRP
                     GTTLIVIAHRAASARRADRVLVMDGPRTRCGDHRELLAASPLYRDLTGAPGPRTPAHAP
                     SHPPRSPRDPDRVDAVAGPGLPGDRRQVVAHGPVGKVQTPGDLPDGGALRGE"
     gene            complement(<16969..17541)
                     /locus_tag="SMD11_RS23525"
                     /pseudo=""
     CDS             complement(<16969..17541)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="SMD11_RS23525"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPGVALAAGGRGGGVVIRVLLVQDTYLLRAALAAFLGREPDLEVL
                     SASWEHAAATSWARWPDVCVVDMDSPDAAGPRGLRELSARCCAGDGTSVLLALATAERP
                     GPLRRAYEEGALGYLSKNASPDQLVEGIRRVAKGERYIDESLGYGFLEAAEIPLTRREL
                     SVLSLAAEGSSIGEIARSLHLSNGTVRN"
     gene            complement(17659..18315)
                     /locus_tag="SMD11_RS23530"
                     /old_locus_tag="SMD11_4771"
     CDS             complement(17659..18315)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605918.1"
                     /locus_tag="SMD11_RS23530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4771"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_087928322.1"
                     /transl_table=11
                     /translation="MTTESKSATASAAPAVSTPLPLTERQEARRRRILDATARLAVRGG
                     FDAVQMREVAESSSVALGTLYRYFPSKIHLLVATMQDQLQQLHGTLRKRPPTEEEPAAR
                     VAQTLMRAFRAMQREPHLADAMVRALTFADRSVSAEVDTVSRLTTAIILDAMGPAGPPT
                     PAQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIETVCRLIDLTSPSAGKCQEV"
     misc_feature    complement(18466..18479)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            18616..19893
                     /locus_tag="SMD11_RS23535"
                     /old_locus_tag="SMD11_4772"
     CDS             18616..19893
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849816.1"
                     /locus_tag="SMD11_RS23535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4772"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_234366448.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.9e-29,
                     bitscore: 100.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIALLSYKGNPFCGGQGVYVRHLSRELARLGHSVEVIGAQPYPV
                     LDEGVTLTELPSLDLYRQPDPFRMPKAGEYRDWVDALEVATMATGGFPEPLTFSLRARR
                     HLAARRGRFDVVHDNQTLGYGLLGGPLTLGAPLVTTIHHPITVDRQLDLDAAADWKRRA
                     SVHRWYGFVRMQKRVARRLPSVLTVSGSSRDEIVDDLGVPAERIHVVPIGADTDLFSPD
                     PSVAEVPGRIVTTSSADVPLKGLVHLVEALATVRAAHPGAHLVVVGKRAENGPVATAIA
                     RHGLGDAIRFVKGVSDAELVDLVRSAQVACVPSLYEGFSLPAAEAMATGTPLLATTGGA
                     IPEVAGPDGETCLAVPPGDAGALAAGLTRLLGDADLRRRLGAAGRERVLARFTWRQAAI
                     GTADHYREAVARYGAADAARRRAGIR"
     gene            19988..20722
                     /locus_tag="SMD11_RS23540"
                     /old_locus_tag="SMD11_4773"
     CDS             19988..20722
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413299.1"
                     /locus_tag="SMD11_RS23540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4773"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_087928324.1"
                     /transl_table=11
                     /translation="MLTVDFTRFPLAAGDRVLDLGCGAGRHAFECYRRGAQVVALDRNG
                     EEIREVAKWFAAMKEAGEAPAGATATAMEGDALALPFPDDTFDVVIISEVMEHIPDDKG
                     VLAEMVRVLKPGGRIAVTVPRYGPEKICWALSDAYHEVEGGHIRIYRGDELLDRMREAG
                     LAPYGTHHAHGLHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPKATRVAEQLLN
                     PVIGKSFVAYATKPHQDGAVAK"
     misc_feature    19992..20006
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            20719..21798
                     /locus_tag="SMD11_RS23545"
                     /old_locus_tag="SMD11_4774"
     CDS             20719..21798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953108.1"
                     /locus_tag="SMD11_RS23545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4774"
                     /product="prenyltransferase"
                     /protein_id="WP_087928325.1"
                     /transl_table=11
                     /translation="MTTFSRGPGRTERLVLPGVLTARQAVQTVAALAAVQREDGAIPWF
                     RGHHLDPWDHVEAAMALDAAGEHARAEAAYRWLADHQNPDGSWYAAYADGDADAPTDRG
                     RETNFVAYVAVGVWHHYLATGDDAFLDRMWPTVFAAVEFVLQLQQPGGQIGWKREEDGT
                     DVTDALLTGSSSIHQALRCALAVAEHREEPQPGWELATGLLAHAIRRHPERFLDKSRYS
                     MDWYYPVLGGALTGPEAKERIEEGWDRFVVPGLGVRCVLPNPWVTGGESCELALALWVM
                     GESDRAVEILQSIQHLRADDGMYWTGYVFDDKAVWPEELTTWTAGSLLLAAAALGGDEA
                     TTAVFGGERLPRGLEPDCC"
     gene            21928..22731
                     /locus_tag="SMD11_RS23550"
                     /old_locus_tag="SMD11_4775"
     CDS             21928..22731
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973376.1"
                     /locus_tag="SMD11_RS23550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4775"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_087928326.1"
                     /transl_table=11
                     /translation="MTHLSYDRYCSEVVTQTTLLREAIRGADLTATVPTCPEWTLAQLL
                     LHVGQAHRYAEGLVRTRTTSFTPTDIGAAPTPGPGDPALDADAAAFGAWLAEGAETLVE
                     TLRASGPDTGVWTFGPRQNADFWARRMTHETVIHRADAEATTGVEFTVAPEIAADCLDE
                     WLQIVSSPMAMEYNPAYKELLGPGRTLHLHATDTAPELEAEWFVDYSGERIEWRRAHEK
                     AAVVVRGPLTDVLSVFYRRQSPADGRVEVLGDRELLEFWLERASF"
ORIGIN
        1 tggtcacacc cgagtacgtc accgcgcacg aggtcttcct cgtccccgac gcggaggacc
       61 ggccgctcgg cttctacgcc ctgctgctcg acgcggccga gctggacctg atgttcgtcg
      121 ccgacgccgc ccaggggctc ggcgtcggcc ggcgcctcgc cgcgcacatg aaggagcggg
      181 cccgcgccgc cgggctgacc cgggtgaagg tgacctccca cccgccgtcc gagggcttct
      241 accgcagcgt cggcgccgtc cgcgtcggct ggtcgcccac gatcccgccc gcgatcacct
      301 ggcagcggcc ggagctggtc ttcgacctcg gcgccggtga ccgcgacgcg cgcggggcgg
      361 cggcgctcac gcgtccctga acgccaccgg agcgtcgaac gccgcccgcc gcgtcgcccg
      421 gcgcagcgcc ttgagcacgg ccgggcccag cgtgagggtg gcgacgaccg tgaccacggc
      481 gcggggcagg tcccagccca gggaggtcgc caggcagtac gccacgaaac ggccgaggtt
      541 ctccgggagc gggtcaccgg ggacgaacga gaccccggtg gccagggcgc cgatgtaggg
      601 ccagccctgg aggttcatga ccgtgccgta gaacagcgac gccaccgccc cgtacccggc
      661 gagcagcacc agctcgcggg cgccgcgcag ccggtccggc cccggcagca ggccggcgcc
      721 catcgccacc cagcccatgg ccagcatctg gaacggcatc cagggcccga ccccgccggt
      781 cagcagcgcg gacgcgaaca tcgagacgga acccaggacg aagccgaagc cggggcccag
      841 gacccggccg gacagcacca tcaggaagaa catcggctcg atgcccgccg tgcccgcgcc
      901 cagcggccgc agcgccgcgc ccgccgccgc gagcacaccg agcatggcga cggccttcgc
      961 gtcgagcccg gtgtcggaga tcgtcgcgac gacgaccgcg aggagcatcg gcagcagcgc
     1021 cgcgaacagc cacggcgcgt ccttggagtg ggcgagcccg gaggacgcgt cggcgagcag
     1081 cggccagccg aaggcggcga cgcccatcgc ggagaccagg acgagcgcgg ccacggacct
     1141 cggcccgagc cggacggccc gcgcctggcg gtcggcggag accttcacct cgccgcccgc
     1201 ctcgcggacc tccccgtgct ccgtcatgcc gtcgcctcca gagaccgccg cacctgcggg
     1261 accgtgagcc acggcaaggg cgccaggacc ttcgccacct gcggcgcgaa cgccggggac
     1321 gccaccacga cctccgccgt cgggccgtcc gcgacgacct cgccgtcggc gatcaccacc
     1381 acccggtgcg ccagctcagc cgccagctcc acgtcgtgcg tggccaggac gatcgcgtgg
     1441 ccgccggcgg ccaggccgcg caggatctcc accaggcggg ccttggccgc gtagtcgagg
     1501 ccgcgggtcg gctcgtccag caggatcagc ggcgggcggg ccgtcagcac gatcgcgagg
     1561 gcgagcgcga gccgctggcc ctcggacagg tcgcgcgggt gggtcgcgtc ggccacgtcc
     1621 ggcagcagct ccgagaccag cgtccggcag gtgcccggcg ccgcgcccgc gtcgccgtcg
     1681 gccgccgcgc actccgccgc gaccgtgtcg gcgcacagca ggtcgcgcgg ctcctgcggg
     1741 acgaggccga cgtggcgcag cagctccgcg ggcgccgtgt ccccgggggt caccccgccc
     1801 acgcgcacgg tcccggcggc gggccggtgc atgccgacca gggtgcgcag cagcgtcgac
     1861 ttcccggcgc cgttgcggcc catgagcgcg acggtctcgc ccgcccgtac ggacaggccg
     1921 atgtcccgca gcgcgaccac ccggccgtgc cggacggcga ggccggtgac ctcggcgggt
     1981 ccgcctgacg ccgggcgcgg ggaccggcgc aggaagccgc cgcgcgggcg cggcgcggcg
     2041 gggcgtccgg ccgggcctgc ggcgccgtcc cgtgaggcgt ccggcccggc cggtggcgcc
     2101 agcggagcca gccgctcccg cagcggggcc gccctgcggc gggcgtcccg tacggacagg
     2161 ggcagcgggg accagccggc gagccgcccg agcgccacga ccggcggctg gaccggcgac
     2221 acggccatga gcgcggcggg gtcgccgagg accggggccg cgccgggcgc gggcagcagg
     2281 aggacctggt ccgcgtactg cacgacgcgc tccagccggt gctcggccat cagcaccgtc
     2341 gtgcccaggt cgtgcaccag gcgctggagc acggccagga cctcctcggc ggcgcccggg
     2401 tcgagggcgg acgtcggctc gtccaggacc agcacccggg ggtgggtggt cagcacggag
     2461 ccgatggcca cccgctgctg ctgaccaccc gacagggtgg cgatcgggcg gtcgcgcagc
     2521 gcggccagcc ccagcaggtc gagggtctcc tcgacgcggc ggcgcatcac tcccggcgcg
     2581 agaccgaggg actccatgcc gtaggccagc tcgtcctcga cgatgtcggt gacgaagtgg
     2641 gccagggggt cctgcccgac ggtccccacc acatcggcca gctcgcgcgg ccggtgggtg
     2701 cgggtgtcgc ggcccgcgac ggtgacccgg ccgtgcaggg tgccgccggt gaagtgcggt
     2761 acgaggccgc tgaccgtgcc cagcagcgtc gacttgccga ccccggacgg gccgacgagc
     2821 agacacagct ccccctcggg cacggtgagg tccaccccgc gcagcgcggg cgcgcccgcc
     2881 ccgtcgtacg agacggacac ctgctcgaac cggatcactg aggggcctcc ttgcggccgg
     2941 gctcgcggcc cgggggagtg gtgggtgcgg cgggggcggc ggcgtcgccg tcaccggtgg
     3001 ccgtcgccgg ccggccggtc gggcgggggc cggtgggcac gccggccgcg gcggtgtcgc
     3061 ggggcccggc cccgggcgtg gagcgggctc cctccgtacg gccttcgggg gccggtgggc
     3121 tgtccgtgcg gccgacgggg gcggcgctgc cggcggggtc ggtcaccggg ccttcggcag
     3181 ggttccgccg gtgtgcggcg gcgtccgccc gggttcccgt cacgtgggcc gcccgcccgc
     3241 gggagctcgc caccgggcgg cgggcgcgtc cggacgggcc gtcaggcccg gtggacggtc
     3301 cggcggtggc ccggaccggt gccggggcca ccacggccgg gagcaggccc agcaggaccg
     3361 acaccgccgg ccacagtggc aggtccggcg cggtcagcgg gaccgccggg gggtgcaggg
     3421 cggcgggggc gtacccgttc gcccagatca tcagggccgc caccgccgcg cccgagcccg
     3481 acaccagcca ggcgcgggtg ccccagcggt ccgggcggta gcgggtgcgg accgagcggc
     3541 ggccgcccag ccacaggccg gccagcgcgg cggcgaggcc cgcgaggagc agcggcaggc
     3601 cgtagcccgc gccctcgtcg gccagcaggc cgtacgtccc ggcgcagacg ccgagcagcc
     3661 cgcccagggt gaggacgttc gtcgtgagcc gcaccgcgcg cgggacccgc gccgtacggc
     3721 cgtagccacg ggcgtccatc gccgccgcca gcgccacgga acgctcaaga gcgccctcca
     3781 gcaccggcag acccacctgg agcagcgcct tgaggccgtg gtccgggcgc ccgcgcagcc
     3841 tgcgcgcggc gcgcagccgc tgcacgtccg ccaccaggtt cggcgcgaac gtcatcgcga
     3901 cgacgatcgc cacccccgcc tcgtacagcg cgcccggcag ggacttcagc agccgcgccg
     3961 ggttcgcgag cgcgttcgcc gcgccgacgc agatcagcag cgtggccagc ttcagcccgt
     4021 cgtagaacgc gaagagcagc ccctcggcgg tcacccggcc gccgatccgc acccccttcg
     4081 cccagtccgg gagcggcacc tccggcaggg tgacgagggt gtgcgtgccc gggatcggcg
     4141 agccgagcac cacggcgaag accagccgga tcccgatgac gaacagaccg atcttgagga
     4201 acgccccgta cgagcgggcc cacggcgcgt ccgtgcgccg cgcggccacc acgtacccgg
     4261 cgacgccgat cagcaggccg agcagcagcg ggttcgtggt gcgcgacgcg gcggtcgcga
     4321 ggcccagggc ccacacccac cacgcgccgg cgtgcagcgc cgaggcgcgg ccggtcagcg
     4381 gggcggcggc cggcgcggcg gcgcggtcgc cgccccggcg cggcggggtc cgtccgctca
     4441 tccgcgacgg cggcgcgcct gccacacggc ggcggcaccg agcacgacca cggcggcgac
     4501 gccaccgatc agaccggccg agggaccgcc gtcgccgtct cctccggagt ccccggcgtt
     4561 ctccgtggcc ccgggggagg cgggcgtgga gctccccttc tccttcttgg gctccccggc
     4621 gccgacctgc tcaccgcagc ccgacctcgg gtagcccgcg atgccgcaca gcagcgccga
     4681 cgagtcgtag cgcagcggct tcgcggcggc cgcgagggcc tcgccggcgc tcgcgtcctt
     4741 cgtcacctgg gcgcacgccg tccgctgcgc gggcggcgtc tcgcccccgg gcgcgtcggc
     4801 gggcgtgccg aagtcgacga cgaccgcgac ccgcttcccg ccgtccttct ccggcgtgtc
     4861 ctcgcacacc gcgtcgaagt cggcctcggc gcgcggcttc gcggcgtcct tggagtcctc
     4921 gctgacggcg aaccggaagc cgatgacgga gccgtcgccg ggccgcgccg tggacgggcc
     4981 ctgcgtggcg tacgcccagc cgtcgccgga gctctcccag aacgaccagt agcggtagcc
     5041 cgccgcctgg gcgggcgcgg cgccgagcgc cgcgagcagc ccggcgagga gcagcgtgcc
     5101 gagggcgcgc gcgccgcgtc cccgcgtcac agctgctgct tcttcttgcg gccgctgatc
     5161 aggaagcccg cgccgacgct ggcgacgaag aagatcccga cgatccacca ggtgccgaag
     5221 cccccgtcgt cgtccttctt ctcgtcgtcc ttcttctccc cggccgactc cgcggcctcc
     5281 ggggccgggc ccgtcgcgtt cagctgcgcg accaggtcgg cgccgccgaa ggagcgcggg
     5341 tcggcgccgg ccgcgtgcgc ggcgagcacc agcttggcga gcttgcccgg gttcttgtcg
     5401 gcccaggcgg ccgtgccgct ctccttggac gcgagccact tcagcggctt ctcggcggcc
     5461 gtacggtggc cgccggcggc cagtgcgatg acggcgtcgg cggtgttgcc ctggtcgggc
     5521 ttggccgggg cgccgggcat ggacggcagg aggtagccgc cgttcttgtc gagcaccgcc
     5581 gtgaggtagc cgtccacggc ctcggccgcc gcggcggcgt ccttcggccg ggcgctgtcg
     5641 tcgccctcgc aggacagcgg cttcaccggc gcgtcggcgt ccttcttcac cgggtcgacc
     5701 aggaagccct taccccgggt ggccagaccc gcggccgcgc tggcgaggtt gtcggcgcgc
     5761 agcccgtcct tgtccttcag gtacgagaag gcgccgcgct cctcctcctt ggcgtcgcag
     5821 ccgagctgga aggtgagcag ggcgtcgacc gggttcttgc cgtccttgac ggcggccttc
     5881 gccgcgtcct gcccggcggc ggcgaacgcg ccgacggcga tggaggtgga gttggcgtcg
     5941 ctggggctgc cggcctggta gccccagccg ccgtcggcgt tctggtgggc cttgagccag
     6001 tcgaggccct tcttcaccgc gtcgccctgc ccgccggcgg ccaccagacc ctgcacggcg
     6061 gcggccgtcg cgtcggtgaa ctcctccttc tgcgggtcgc acgccttcga ggtgtccgcg
     6121 cggtagccgg ggaaggcacc gtccgcgcac tgctgcccgg tcagccagtc gaccgcggac
     6181 ttcgcgggcc tgacccccac cgcgtcctgc gccacgaagg ccagggactg ccggaagaca
     6241 ccgtcgaact tcgggtcggt cgtgccgtac agcccggact tcggcgacgg ggacgcgtcg
     6301 gcgaaggcgg cgggagccat ggccgcgctc agcacggcgg cggcggccag ggccgcggcg
     6361 ccacggcgcg cggggacggc gagggagggg gccatgggtc ggtgcctctc ggtgggtgtc
     6421 actgcggtgg ccggcccgcc agggagggtg cgcagccccg cacggcagct ccgccgcgag
     6481 gtccgcgcgg tggcaccggg cgcggctccg tatacctcga cggtgccggt gggccgggcg
     6541 gcgccgacgg gcggcgcgac cggctccgga agccttgccg ccagggaccg ggtggtccgg
     6601 ctcgcacggc cggccgcggg ggcgggccgt ggtcacggtt gcgggtcagc gccggattcg
     6661 caccggtctt tccccgttcc gcggcgggat gaagttgtca cgcacacttt agccgtccct
     6721 ttacaccgtg ctcataccgc cacgtatgcg accgggtggc tgcccggcac ggcctcggcc
     6781 tgccgccgcg cgacgaggtg gcgcaggtgc gcctcggcct cggcgacggc gatgttccgg
     6841 gaggcgtacg ggatccggtc ccaggggcgg ttccacgcca tggacgcggt gagctgccac
     6901 agcgtccggg gcgtgcccag cagcgcgcgg agctcggcga gccgggcgcg gtggtgggcg
     6961 aggagctccc gcacccggcc gggggcgtcg gtgaaggcgt gctggtgggc ggggagcact
     7021 tcggcggggt ccagggcggc gacgcgcgcg agggaggaga ggtagtcgcc gagcgggtcg
     7081 gcggggccct cgccgggggc gcgggcgggc tcgtagatct cgtagaggcc cacgtgcggg
     7141 gtgatccccg gcagcaggtg gtcgccggag aagagccggc cgttgcccgc gccgccgtgc
     7201 ggatgggcct cctccaggtg caggcagacg tggccggggg tgtgccccgg ggtccagacg
     7261 gcgcgcagcc ggcggccggg caggtcgagc agctcgccgt ggacgagctc gcggtccggc
     7321 agcgccgccc gccgcccggg cagttcccgg gcggcggccc gcgccgcctc cagccgcgcc
     7381 acgtgcccgg cgggcgcgcc ggccgccgtc agcttcccgg cgagcaggtc gatccagccg
     7441 ccgggcggcg tcccgcgcag gtggcggacc agctccgtgt cggcggggtg catcgcgatc
     7501 caggcgccgg aggcctcgcg cacccggccc gacaggccgt ggtggtccgg gtggtggtgg
     7561 gtgacgagga cgccgtgcag cgccgccacg gacgtgccgc aggcggccag gcccgcggtg
     7621 agggcgtccc aggaggcggg gtcgtcccag ccggtgtcga cgaggaccgg gccgcggccg
     7681 gtgtccagga ggtggacgag cgtgtggccg agggggttgc cggggatcgg gacggggacg
     7741 gaccacacgc cgccgccgtg gtcggtcacc gggggtgggg gcggggcggg cgttccgggc
     7801 ggccccggtg tcccgggcgg cccgggtggt cctggcgtcg cgggtgtgcg cggtacgtcc
     7861 ggcacgtgcg ccatgggcac ctcccccgtc accgccgcac ggcggccatt gcccactata
     7921 acgagaactg ctatcagttc tgatgctgcg tcagatcggc gtcggggccg gcgccgagcc
     7981 gcgtcggatc tactgggcgg gcgcaccgcc cgcccgtggg aggcaccggg caatgggcga
     8041 actcatcgag tacgggcagc tgttcatcgg cggcgccatg accgacccgg ccggccggga
     8101 caccatcgac gtcgtctcgc cgcacaccga gcgcgtcatc ggacgcgtac cgcacgccgg
     8161 cttcgaggac gtcgaccggg ccgtggccgc cgcccgggcg tccttcgact ccggcgtctg
     8221 ggccggcctg ccgctggccg ggcggatcga ggtcgtcacc cggatcaagg acgggatcgc
     8281 cgcccgccac gaggagctcg cccggaccat ctccgccgag aacggctccc cctactcctg
     8341 gagcgtcctc gcgcaggcgc tcggcgcgat gatggtgtgg gactgcgcca tcggtgtcgc
     8401 gcgcgacatc ccttacgagg agcggcgcgg cggcgtcctc gggccgctgg tggtgcggcg
     8461 cgagccggtc ggggtggtcg cggcggtcgt cccctggaac gtgccgcagt tcgtggccgc
     8521 ggccaagctg gcgcccgccc tgctggcggg ctgctccgtg atcctcaagc cgtcgccgga
     8581 gacgcccctg gacgcgtatc tgctcgccga gatcgtcgcc gcggccgggc tgccggaggg
     8641 cgtgctgtcg atcctgcccg ccggaccgga gaccggcgag tacctggtcg ggcaccccgg
     8701 cgtcgacaag gtctccttca ccggctcggt cgcggccggc aagcgcgtca tggaggtcgc
     8761 ctcccgccac ctcacccggg tcacgctgga gctgggcggc aagtccgcgg ccgtcgtcct
     8821 gcccgacgcc gacctggacg cggccgtcgc cggcatcgtg ccgagcgcct ggatgaacaa
     8881 cggccaggcc tgcgtcgcgc agacccgcat cctcgccccg cgcgtccact acgacgagct
     8941 cgccgagcgg ttcgcggccg cggcccgcgc cctcgtcgtc ggcgaccccc tcgacccggc
     9001 cacccaggtc gggccgctgg tcgcggagcg gcagcggcgg cgctcgctgg actacatcgc
     9061 gctcgggcgg cgcgagggcg ccaaggtgct cgcgggcggc ggccgcccgg ccgggctcga
     9121 caccggctgg tacgtcgagc ccacgctgtt cggcgacgtc ggcaacacca tgcggatcgc
     9181 ccgcgaggag atcttcgggc cggtcatctg cctgctgccc tacgacacgg aggaggaggc
     9241 cgtccggatc gccgacgact ccgactacgg gctctccggc agcgtctgga cccgcgacgt
     9301 cgagcacggc ctggacatcg cgcgccgggt gcgcaccgga acgtactcgg tgaacacctt
     9361 cagcctcgac atgctcggcc ccttcggcgg ctacaagaac tccggcctgg gccgggagtt
     9421 cggccccgag ggcttcgccg agtaccagga gcacaagatg atccacctgc ccgccgggca
     9481 cggggagggc tgatggccga gcgctggcgc gtcacggtgg accggcgcgt gtgcgtcggc
     9541 tcggggctgt gcgccggcct cgcccccgag gccttccggc tcgatccggc gcgcaggtcc
     9601 cacccggtgc cgggcgcgag gggggagtcc gaacgggtgc gtgaggcggc ggagatgtgc
     9661 ccggtcgagg cgatcgcgat cgcactcgcg gacacggggg aggcggtgtt cccgccgccg
     9721 gagtgacggg tggggtgccg aacgggggcg gggcggcggc cgggcgccgc cggccccgtg
     9781 atccgcgcgc ggccgtccgg cgaccggctt cggggccgtc cggtgatccg cgcgggaccg
     9841 gcccggtggc ccgtcggcgg gtggtgggcc gctgacctgg gacggatccg tccgcgcctg
     9901 gttactcatg cgttccgcac tgcctgttca tgacatgtgt gactggttcg cctctcaacg
     9961 gcgtggaaat ctcgacgcaa cggagccgag gggggaaccg atggacaagc ggtacgaggt
    10021 ctactgcctg gcggacaggc acttctacga gaccccggac cgtctgtccc tcccggccgg
    10081 cggcgcgccg gaggccggtg gcgggttcta cgagaccgcc cgccgcccgg tgcccgccgg
    10141 ctggcacacc tcccgcaccg gcgactggct gcacctcacg cccgtggacg ccgacggcgc
    10201 cccgcgcccc gggcagccgc cccagggctg gaagatccac gtgtcggcga cggccgcgag
    10261 cgcggagaag accgccgccg ccgtctggga ccactgcgtc ccgaggggca tccccttcaa
    10321 gttcgtcccc gccccgcacc tgctgcacct gcgcaacagc aaatacgcgg ggcgcgacca
    10381 cagcggaaag ttcgtcacgg tctacccgaa ggacgaggag caactccacg ccacgctcac
    10441 cgagttgcac gaggtcgtcg gcggcaggcc cggcccgtac gtcctcacgg acctccgctg
    10501 gcacgacggc ccgctctacg tccgctacgg cgccttcgcc cgccggttct gcgtcgacgc
    10561 gcgcggcacg ctcgtccccg cgatcgagga cggcgaaggg cggctggtgc ccgaccgccg
    10621 cgaccccgcg ttccacgtcc ccgactgggt gacgctgccc gccttcctgg agccccacct
    10681 cgccgcccgc aacgccacca cggtcggcga gctgccctac cgcatcgaga aggccctgca
    10741 cttctccaac ggcggcggcg tctacgccgg caccgacacc cgcgacggcc ggaaggtcgt
    10801 cctcaaggag gcccggccgc acgccggcct cgccgccgac ggcgcggacg ccgtcgcccg
    10861 gctggagcgc gagcgggccg ccctggagaa gctctccggg ctcggcgtgg ctcccgaggt
    10921 gcgtgactgg ttcaccctcg gcgagcacag cttcctcgtc atggacttcg tcgagggccg
    10981 cctcctcaac tcctacttct ccgagcgtca ccccctgatc gccgccaccc cggccaccac
    11041 cgccgtggcc gactacacgg cctgggcgct gcgcgtccac gccgcggtcg aggaggccgt
    11101 ggccctggtg cactccaggg gagtggtctt caacgacctg cacatgttca acatcatggt
    11161 cgcccccgac gaacgctcgg tgaccctcat cgacttcgag gccgccgccc ccgccgccga
    11221 gcacggccgc cagatcgtcg cccaccccgg cttcgtcgcc ccgccggacc gcaccggcac
    11281 cgaggtcgac cgctacgccc tggcgtgcct gcggctggcg ctgttcctgc cggtgaccat
    11341 gctcttcgcc atcgaccgcg gcaaggccgc ccatctggcc gaggtgatcg ccgaggagtt
    11401 ccccgaggtg ccggaggagt tcctggcgga ggccgtggcg gagatcgccg gggaaggggc
    11461 gggcggccgg gcggccggcg gtggccccgg ccgtggcgcc cacgacggcg cgggcgggcg
    11521 cgcgggcagc ggtgccgccg ggggttccgg cagcggcgtc cacggtgacg tgcgtacggc
    11581 cggcggccgt ggggcgcccg gggggacccg ctccggtacg ggcggtggag ccgtcggcgg
    11641 ctccgggagc gaccccggcc gtggcgtcca cgcgggcacg gccacccgcc gtggggcgga
    11701 cgggcgagcc ggctccgccg cggtgcccgc cgccgcccgt cgcccccgcg cgggagcgca
    11761 ccccgcgccc ggggactggc cacgcagccg ggactcgatg gcgcgggcga tcctcgcctc
    11821 cgccaccccc gaccgtgccg accggctctt cccgggcgac atcgcgcagt tcggcgacgg
    11881 cggcgggctc ggcctcgcgc acggcgccgc cggggtgctg cacgccctcg ccgagaccgg
    11941 cgcggaccgc tacgagcggg gcgagcgctg gctcctcgac cacaccgacc cgctgccgcc
    12001 gggcaccccg ctcggcctct acgacggtgt cgccggcgtc gcctgcgtcc tcgaccggct
    12061 cggccacacc cggcgcgccc tcgacctcgc cgcgaccgtc ctcgcagaga agtggcagcg
    12121 gctcacctcc gacctccaca gcggcctggc cggagtcggc ctcgccctcg accacctcgc
    12181 ccggaccacc ggcgagcggc agctccacga ccaggccgtc gaagccgccc agctcctcgc
    12241 cgaccggctg gccgccgacc tcgcgtcccc cgccgccggc cgccgccggg ccggcctgat
    12301 gcacggcgcg agcggccccg ccctgctctt cctccggctc cacgaacgca ccggggcccc
    12361 cgccctgctc gaactcgccg agcgggccct gcgcgccgac ctcgcccgct gcgtcacgac
    12421 ccccaacggc accctggagg tcgacgaggg ctggcgcacg atgccctacc tgggcgacgg
    12481 cagcgtcggc gtcggcatgg tcctcgacga cttcctcgac cgcgccgccc ggcgcgggac
    12541 cgccgccgac ccggcgctgg ccgaggcccg cacgggcatc ctccgcgccg cgcgctcgcg
    12601 gttctacgtc cagcccggcc tcctccaggg ccgcgccggc atggtcctgc acctcggccg
    12661 cacgaccgca cccggcgtca ccgcggagca cctggccacc caggtccgcg gactgtcctg
    12721 gtacgcgatg gcctacgaag gggaactcgc cttccccggc agccagatga tgcggctgtc
    12781 catggacctc gccaccggaa cggcgggcgt cctgctggcc ctgggcgccg cgctcggcgc
    12841 ccccggcggc ccggcgccgc aactcccctt cctgccgccc ctgagggcgc ccaaggaccg
    12901 gctccgcacg gagccgtagc accaccatcc gtccccatga aaggaaagac catggccctt
    12961 ctcgaccttc agaacatgga ctccgaggag tacggcggcg gccacggcgg cggaggcagc
    13021 aacgtgagcc ttctcctctg ctggagcacg gccagcgtcg cgctctgcct gtgacacgga
    13081 gccggtagac accagggacc gggcgggcac cctcacgggg cccgtccggt cccaccggca
    13141 gtaccgacgg caccggcggc atcgacggca ctgtccacgg gcagtgccga cggcatcgac
    13201 agcgagggct gcgacgaccc catggcacag accagtaccg cccccgccgg agcgcccggc
    13261 gagcggcacc ccggcgaccg gatcctgctc gacgcgaccc ggcacagcgc cgcccgcgcc
    13321 gcggccctgg ccctgatcgc cgtcgccgcc accggcgcca ccctgctgct gcccgccgcc
    13381 ctcggccaca ccctcgacct cctcctcgcc cggcgcggcg ccgaggcgac ccgctgggtc
    13441 ctgctctgcg cgggcctcgt ctgcgccccc gccgcgctcg acgccctcga cgaggtgctc
    13501 tccggcacca ccgcagcccg caccacggcc tggctgcgcc accgcctgct ggcccacgtc
    13561 ctcgccgccg ggccccgcgc caccgcccgc ttcgcccccg gagacctcgt cacccgcctc
    13621 gtcggcaacg ccgccgacgt cggcaccgcc cccggcacgc tcgccggatc cgccgccgcc
    13681 gtcgccgccc cgctgggcgg cgtcctcgcg ctcggcctca tcgacccctg gctcgccgtc
    13741 gggttcctcg ccggggcgcc cctgctcgcc ctgctgctgc gggccttcgc ccgcgcctcc
    13801 ggcgactgcg cggcggagta ccagcggctc cagggagaga tcgccgggcg cctcgtcgag
    13861 gcggtcggcg gcgcccggac catcgcggcc gccggcaccg cgcggcggga gaccgcccgc
    13921 gtgctcgccc cgctgcccgg cctgtcccac caggggcacc gcatgtggcg ggtgcagggc
    13981 cgggccgccg cgcaggccgt cacggtcgtg ccgctgctcc agatcaccgt gctggccgtc
    14041 gccggcctgc gcctcaccca gggggcgctc agcgtcggcg acctcctcgc cgcctcgcgc
    14101 tacgcggtgc tcgccaccgg ggtcggcgtg ctcgtcggcc acgtgagcgc gatcgtccgg
    14161 gcccgtacgg ccgcggggcg cgtcgccgag gtcctggcag agcccgccac ggcgcacggc
    14221 tactgccaac tgccggccgc cggcgccggc accctggagc tgcgcggcgt cagcgcggag
    14281 cgcggcgggc ggacggtgct gcgcgacgtc gacctcgtgg tgccgggcgg cacgtccctg
    14341 gccgtcgtcg gccgctccgg caccggcaag tcggtgctcg cggagctcgc cgggcggctc
    14401 gccgacccgg ccgccggggt ggtgacgctc gacggcgtcc ccctgcgcga gctcggccac
    14461 gacaccctgc ggcgcgccgt cggctacgcc ttcgcccggc ccgccccgct gggcggcacg
    14521 atcggcggca cgatcgcctt cggcgtcttc gaccccggac ccgacgccgt cacggaagcc
    14581 gcccgcgcgg cgtgcgcgga cggcttcgtg cgccgcatgc cgctcggcta cgccacgccc
    14641 tgcgaggacg ctccgctgtc cggcggcgag tcccaacgcc tgggcctggc ccgcgccttc
    14701 gcccacgcgg gccgcgtcct gatcctggac gacgcgacgt ccagcctcga caccctcacc
    14761 gaacacgagg tcacccgcgc cctccacggc accaccaccc gcacccgcct cgtcgtcgcc
    14821 caccgcgcct cgacggccgc ccgggccgac cgcgtcgcct ggctcgccga cggccgcctc
    14881 cgcgcgacgg gcacccacga ggacctatgg cgcgacccgg agtaccgggc gctcttcggc
    14941 gcgcggtgac ccccgcccgg ggcgccccgg cccgcccgcg gacgggagcg gcacctctgc
    15001 ccgcccgacc gcggccgccc gggggcgcgt tcaggcggtc cggcgtatcc cggtggccgg
    15061 catgtcgcgg tggcccggcg tcgccgcccg accggccgcg ggccggcggc cgcacccctg
    15121 tcccggccgc cccggcccag accccaggag gtccccatgc ctgagcgccg tcgtggcggc
    15181 ggccgtgacg acggcggcgg tgtcgcacgc cgagggctgc gcttcctgcg ccgccggcgg
    15241 gccgtcgtcg cgtggctggc cgtgtggtcc gtggtcgagg ccgcgcacac cttcgggctg
    15301 gggtacgcgc tggccagagc gctggactcc gggttcctcg cggggcgggc cggggtcggg
    15361 ctcgggtggc tcggggcggc cgccggggcc gtggtcgtcg gggcgtacgg gaccgggcgt
    15421 acgtacggcg gcgtcgccgg gctcgtggag ccgctgcgcg acggactcgt gcggcgcgtg
    15481 gtcccggccg ccctgcggga cgccgacggc gccgccgtct cccggctgac ccaccaggtg
    15541 gagatcgccc gggacgcctt cgccgggctc gtgatggtct cgcggtcctt cgtcttcacg
    15601 gcggccggcg ccctgacggg cctgttcctg ctgtccccgg ccctcctggt ggtcgtggtg
    15661 ccaccgctcg cgctcggcct cggcctgttc ctcgcgaccc tgcggcccct ggcccgccgc
    15721 caggaggcct tcctcatcgc cgacgaggcc gtcgcccgct ccttcggcga ggtctccgcc
    15781 gggctgcgcg acatcacggc cggcggcgcc gaacggcggg tccgcgaggg gacgggcgcc
    15841 ctcgtcgacg ccgagcgccg ggcctccgcg gccctcgccc gctggtccgt cgtgcgcgtc
    15901 gtggccctgg ccgtcgccgg ccaggtcccc gtcgtcctcc tgctcgccgc gacgccctgg
    15961 ctgctcgacc gctccgtcac ccccggcgcc ctcgtcggcg ccctcgccta cctcacgcag
    16021 tccctcctgc cggccctcca gaacctcgtg cacggcctcg gcggaagcgg ctcccgcctc
    16081 gccgtcgtgc tgcgccgcct caccgccggc ccgccgcccg cccccgccgc gcgccccacg
    16141 ggcgggcacc cggcggccgc gcccaccacc cccgccgtcg agctgcgcgg cgtcaccttc
    16201 gcgtacggcg agcacgccga tcccgtcgtc gacggcctgg acctggccgt gcccgccggc
    16261 tcccacctcg ccgtcgtcgg ccccagcggg gtcggcaagt cgacgctggc cgggctgatg
    16321 gcggggctgc tggtaccccg gagcggcgag gtgcggatcg gcgggcggcc gccgggcgac
    16381 ccggccggcc gggtgctcat cccgcaggag gcgtacgtct tctccggcac cctcggcgac
    16441 aacctgcgct atctgcgcgc ggatccggtc accgagcggg agctcaccga ggcggccgag
    16501 gccctcggca tgtccgggct cgtcgcgcgg ctcggcggct tcggggcgcg gctcgccccc
    16561 gacgcgctgt ccgcggggga gcggcagcag atcgccctgg cccgcgccta tctctcgccc
    16621 gctcccgtcg cgctgctgga cgaggcgacg tgccacctcg accccgccgc cgaagcccgc
    16681 gccgagcggg ccttcgcgcg gcggcccggc accaccctga tcgtcatcgc gcaccgggcc
    16741 gcctcggccc gccgcgcgga ccgcgtcctg gtgatggacg gcccgcgcac ccgctgcggg
    16801 gaccaccgcg aactgctggc ggcgtccccg ctctaccgtg acctcaccgg ggccccgggc
    16861 ccgcgcactc cggcgcacgc cccctcacac ccaccccgct ccccgcgaga tccggatcgc
    16921 gtcgacgcgg ttgcgggccc cggtcttccg ggtgatcgcc gccaggtagt tgcgcacggt
    16981 cccgttggaa aggtgcagac tccgggcgat ctccccgatg gaggagccct ccgcggcgag
    17041 tgagagcacg ctgagctcac gtctcgtcag cgggatctcg gcggcctcca gaaagccgta
    17101 gccgagcgac tcgtcgatgt agcgctcgcc cttcgccacc cgccttatgc cctcgaccaa
    17161 ctggtcggga gaagcgtttt tgctcaagta ccccaaggcc ccctcctcgt acgcccggcg
    17221 cagcggcccc ggccgctccg ccgtcgccag ggccagcagg accgaggtgc cgtcccccgc
    17281 gcaacatcgg gcggacagct cccgcaggcc ccgtggtccc gcggcgtcgg ggctgtccat
    17341 gtccacgacg cagacgtcgg gccagcgcgc ccacgacgtg gccgccgcgt gctcccagga
    17401 ggcggagagg acctccagat cgggctccct gccgaggaat gccgccagcg ccgcgcgcag
    17461 cagataggtg tcctgtacca gtagaacccg gatcacgacc ccgcctcccc gtcccccggc
    17521 ggcgagcgct acgccgggca cgtcgacaat tcatacggcg tgtacctctg tcgcgggcgc
    17581 ggaatacctc acctgtgggg ggcgcaaggg cgcacgatac gagccacgcg cgccccaagt
    17641 tcactcgaac gcgccgccct aaacctcttg gcatttcccg gcggatggtg aggtgaggtc
    17701 gatcagccgg cacacggtct cgatgtcgat cttcacctgg gcgatggagg cccgccccga
    17761 cagccaggtg atgagggccg agtgccaggt gtgctcgatg acgcggacgg ccgagagctg
    17821 cgcgggcgtc ggcgggccgg ccggccccat cgcgtccagg atgatggccg tggtgagccg
    17881 cgagacggtg tcgacctcgg cgctcaccga gcggtcggcg aaggtcaggg cgcgcaccat
    17941 cgcgtcggcc aggtgcggct cgcgctgcat cgcccggaag gcgcgcatca gggtctgggc
    18001 cacacgcgcg gccggctcct cctccgtcgg cggccgcttg cgcagggtcc cgtgcagttg
    18061 ctggagctgg tcctgcatcg tggcgaccag cagatggatc ttggacggga agtagcggta
    18121 gagcgtgccg agcgccacgc tcgacgactc ggcgacctcc cgcatctgca ccgcgtcgaa
    18181 accgccgcgg acggccagcc gcgccgtggc gtccaggatg cgccgccgac gcgcttcctg
    18241 acgctcggtc aggggaagag gggtgctgac ggcgggcgcg gccgatgcgg tcgccgactt
    18301 ggattccgta gtcatatgtc ccattccgtg gcggtccatc cagcggtatc tgtgcagccc
    18361 ggacggcaca gcatggcagg ggccgggtcg tggcgcgaat cacccgatcc ggtcctgtcg
    18421 gccgcccgtc cggccggtag attcaagctt ctggacaacc cagtctgaaa cttgttctag
    18481 attagcgcga ccggttacgc tccggcggga acagcagcga gaaggaggcc gggagtgacc
    18541 gctgaggcca cagaggcagc actcgcgcga gagggcggcc tccccggccg ggacgtctcc
    18601 cgcacggaac gcccgttgcg catcgcgctg ctcagctaca agggcaaccc gttctgcggc
    18661 ggccagggcg tctacgtgcg ccacctctcc cgcgaactcg cccggctcgg ccacagcgtc
    18721 gaggtcatcg gcgcccagcc gtaccccgtc ctcgacgagg gcgtcaccct caccgagctc
    18781 cccagcctcg acctctaccg gcagccggac cccttccgca tgcccaaggc gggcgagtac
    18841 cgcgactggg tcgacgcgct ggaggtcgcc accatggcca ccggcggctt ccccgagccg
    18901 ctcaccttca gcctgcgcgc ccgccgccat ctcgccgccc gccgcggccg gttcgacgtc
    18961 gtgcacgaca accagaccct cggctacggc ctcctcggcg gccccctcac cctgggcgcc
    19021 ccgctcgtca ccaccatcca ccaccccatc accgtcgacc ggcagctcga cctcgacgcc
    19081 gccgccgact ggaagcgccg cgcctccgtg caccgctggt acgggttcgt ccggatgcag
    19141 aagcgcgtcg cccgccggct gccgtccgtc ctgaccgtct ccggctcctc ccgcgacgag
    19201 atcgtcgacg acctcggggt gcccgccgag cggatccacg tcgtccccat cggcgccgac
    19261 accgaccttt tctccccgga cccgtccgtc gccgaggtgc ccggccggat cgtcaccacc
    19321 tccagtgccg acgtccccct caagggcctg gtccacctcg tcgaggcgct cgccaccgtg
    19381 cgcgccgccc accccggcgc ccacctcgtc gtcgtcggca agcgcgccga gaacggcccg
    19441 gtggccacgg ccatcgcgcg gcacgggctc ggcgacgcca tccgcttcgt caagggcgtc
    19501 agcgacgccg aactcgtcga cctcgtccgc tcggcacagg tcgcctgcgt cccctccctc
    19561 tacgagggct tctcgctgcc cgccgccgag gccatggcca ccggcacccc gctgctggcc
    19621 accaccggcg gcgccatccc cgaggtcgcc ggccccgacg gcgagacctg cctggccgtg
    19681 ccgcccggcg acgcgggcgc cctcgccgcg ggcctcaccc ggctgctcgg cgacgcggac
    19741 ctgcgccgcc gcctcggcgc ggcgggccgc gagcgggtgc tcgcccgctt cacctggcgg
    19801 caggccgcga tcggcacggc cgaccactac cgtgaggccg tcgcccggta cggtgccgcc
    19861 gacgcggccc gccgccgggc gggcatccgg tagcccgccc cgcccgccgg gcccggccgt
    19921 ccgccgaccg tgctccgacc gcccctgatc cgacctgacc tgccccgccg gacgaaagca
    19981 gacctccgtg ctgaccgtcg atttcacccg cttcccgctc gccgccggcg accgcgtgct
    20041 cgacctgggc tgcggcgcgg gccggcacgc cttcgagtgc taccggcgcg gcgcgcaggt
    20101 cgtggccctc gaccgcaacg gcgaggagat acgcgaggtc gccaagtggt tcgccgcgat
    20161 gaaggaggcc ggtgaggccc cggccggcgc caccgccacc gccatggagg gcgacgccct
    20221 cgcgctgccc ttccccgacg acaccttcga cgtcgtcatc atctccgagg tcatggagca
    20281 catccccgac gacaagggcg tcctcgccga gatggtccgc gtcctcaagc ccggcggccg
    20341 catcgccgtc accgtcccgc gctacggccc ggagaagatc tgctgggcgc tctccgacgc
    20401 gtaccacgag gtcgaggggg gccacatccg catctaccgc ggtgacgaac tcctcgaccg
    20461 gatgcgggag gcgggcctcg cgccctacgg cactcaccac gcccacggcc tgcacagccc
    20521 gtactggtgg ctcaagtgcg ccttcggcgt cgacaacgac aaggcgctgc ccgtccgcgc
    20581 ctaccacaag ctgctggtct gggacatcat gaagaagccc aaggccaccc gggtcgccga
    20641 gcagctcctc aaccccgtca tcggcaagag cttcgtcgcc tacgcgacca agccgcacca
    20701 ggacggggcg gtcgccaagt gaccaccttc agccgcggcc ccggccgcac cgaacggctc
    20761 gtcctgcccg gcgtgctgac cgcgcgacag gccgtccaga cggtcgccgc cctcgccgcc
    20821 gtgcagcgcg aggacggcgc cataccctgg ttccggggcc accacctcga cccctgggac
    20881 cacgtcgagg ccgccatggc cctggacgcc gccggcgagc acgcccgcgc cgaggccgcc
    20941 taccgctggc tcgccgacca ccagaacccc gacggctcct ggtacgccgc ctacgccgac
    21001 ggcgacgccg acgcccccac cgaccggggc cgggagacca acttcgtcgc ctacgtcgcc
    21061 gtcggcgtct ggcaccacta cctcgccacc ggcgacgacg ctttcctcga ccgcatgtgg
    21121 ccgaccgtct tcgccgccgt cgagttcgtc ctccagctcc agcagccggg cggccagatc
    21181 ggctggaagc gggaggagga cggcacggac gtcaccgacg ccctgctcac cggctcctcc
    21241 tcgatccacc aggcgctgcg ctgcgccctc gccgtcgccg agcaccggga ggagccccag
    21301 cccggctggg agctggccac cggcctcctc gcgcacgcga tccgccgcca ccccgagcgc
    21361 ttcctcgaca agagccgcta ctccatggac tggtactacc cggtgctcgg cggcgcgctg
    21421 accggccccg aggccaagga gcgcatagag gagggctggg accgcttcgt cgtccccggc
    21481 ctcggcgtcc gctgcgtcct ccccaacccc tgggtcaccg gcggcgagag ctgcgaactc
    21541 gccctggctc tctgggtgat gggcgagtcc gaccgcgccg tggagatcct ccagtcgatc
    21601 cagcacctgc gcgccgacga cggcatgtac tggacgggct acgtcttcga cgacaaggcc
    21661 gtctggcccg aggagctcac gacgtggacg gcggggtcgc tgctgctggc ggcggcggcg
    21721 ctgggcggcg acgaggcgac gacggcggtc ttcggcgggg agcggctgcc gcgggggctc
    21781 gaaccggatt gctgctagga gggtgacggg acgggccggc ttcagcccgt ccggcgtttg
    21841 aggaccgggg tccggggcgg agccccggtt cgggaagggg cgggactggg gagatcccct
    21901 gtcagtgccc cgacctaagg tggcgtcatg actcacctca gctacgaccg ttactgttcc
    21961 gaggtcgtca cccaaaccac cctcctccgc gaggcgatcc gcggcgcgga cctcaccgcc
    22021 accgtcccca cctgccccga gtggaccctg gcccagctcc tcctgcacgt cggccaggcc
    22081 caccgttacg ccgagggcct cgtgcggacg cggaccacct ccttcacgcc gaccgacatc
    22141 ggcgccgccc ccacccccgg ccccggtgac ccggccctcg acgccgacgc ggccgcgttc
    22201 ggcgcctggc tcgccgaggg cgccgagacc ctggtggaga ccctgcgcgc gagcgggccc
    22261 gacaccgggg tgtggacctt cgggccgcgg cagaacgccg acttctgggc ccgccggatg
    22321 acgcacgaga cggtgatcca ccgggccgac gccgaggcca ccacgggcgt ggagttcacc
    22381 gtggccccgg agatcgccgc cgactgcctc gacgagtggc tccagatcgt cagctcaccc
    22441 atggcgatgg agtacaaccc ggcgtacaag gagctgctcg gccccggccg caccctgcac
    22501 ctgcacgcca cggacaccgc tcccgagctg gaggcggagt ggttcgtcga ctacagcggc
    22561 gagcggatcg agtggcgccg cgcccacgag aaggcggccg tcgtcgtgcg cggcccgctg
    22621 accgacgtgc tgagcgtctt ctaccggcgg cagtcgccgg ccgacggccg cgtcgaggtc
    22681 ctgggcgacc gcgagctgct cgaattctgg ctggagcggg ccagcttctg atcacgtccg
    22741 cgggcggggt gagagcatcg ggaccatgac cgacaccctc cgacgaccct ccgtccggca
    22801 cgcgcccgcg gtccgccgcc gggcgccgcg ccgggcggcc gcccgggccc tgccggcggc
    22861 cgcggcgctg gcgctcgtcg cctcctgcac cgtcggcggt ggcggcacgg cgagggcgg
//
