LOCUS       NZ_CP021744            10351 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces albireticuli strain MDJK11 chromosome, complete genome.
ACCESSION   NZ_CP021744
VERSION     NZ_CP021744.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces albireticuli
  ORGANISM  Streptomyces albireticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Streptomyces albireticuli Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2017) Department of Mcrobiology, Shandong
            Agricultural University, No.61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 2.3
            Expected Final Version            :: yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 07:12:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,975
            CDSs (total)                      :: 6,876
            Genes (coding)                    :: 6,711
            CDSs (with protein)               :: 6,711
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 165
            CDSs (without protein)            :: 165
            Pseudo Genes (ambiguous residues) :: 0 of 165
            Pseudo Genes (frameshifted)       :: 74 of 165
            Pseudo Genes (incomplete)         :: 97 of 165
            Pseudo Genes (internal stop)      :: 5 of 165
            Pseudo Genes (multiple problems)  :: 9 of 165
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:17:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5114277
            Orig. end                         :: 5124628
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021744.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10351
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="24"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10351
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10351
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5351](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5351)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(1330..2286)
                     /locus_tag="SMD11_RS22075"
                     /old_locus_tag="SMD11_4469"
     CDS             complement(1330..2286)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982420.1"
                     /locus_tag="SMD11_RS22075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4469"
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_199844082.1"
                     /transl_table=11
                     /translation="MSRGRSLALATAAAGCALAATAAALVPAGTAEHRVTTVADRADRA
                     AAAPATCTDPEASLRPGDGADGPAVRRIKSRGRLIAGVDQDSFRWGYRNPSTGELSGFD
                     IDLTRAIAKDILGDADKVTFLAIPTSQRIPALEKGKVDLIARTMSITCDRIRQVAFSTA
                     YFVAGQQILAPRGSSVTAFDDSLKGKKVCAAKGATAESKMREQPHGARLVTVPNQLDCL
                     VRLQLGQVDAVLTDNALGAGLAAQDPSVELVGKPFTTDPYGVAMNLRDEDLVRRVNKVL
                     DDYRSGGGDSPWMRAYTKWLAADLKGYTAPPAPKYRD"
     gene            complement(2469..3803)
                     /locus_tag="SMD11_RS22080"
                     /old_locus_tag="SMD11_4470"
     CDS             complement(2469..3803)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016826235.1"
                     /locus_tag="SMD11_RS22080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4470"
                     /product="hypothetical protein"
                     /protein_id="WP_087930666.1"
                     /transl_table=11
                     /translation="MPAAWREAADRLRAVATTEPGRLRAIGALLALLLVAFGAVTAWQV
                     ADRASAADAVVGSSQPLSADAADVYRSLADADTTAASGFLAGSRETPAVRQRYEKDIAL
                     AAGLLVKAAANAEGSDTARRQISRLNELLPRYTGLVESARANNRQGLPLGGAYLRTAGD
                     LMRDDLLPAARELYETETGRLGSDYSDAKAWPWASLVLGLAALGALGWAQRRTYLRTHR
                     VFNHGMLAATATAVVVLLWLTVGHALARSDLEGSSAQGARSLQVLNEARIGSLQARGDE
                     NLTLVARGAVLTENKDDAYEASYREGMRKLVGDGRGAAAPGTLLARARALAEDSEGRAA
                     VDAAVRDVREWQVRHAEARAADDSGDYDRALPKVIGEKGSTGESFDRVDEQLRRALAHE
                     QRDFRAAADDGRGALAGLAAGAVVLAVLGAAGAVLGIGRRLSEYR"
     misc_feature    4102..4115
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            complement(4130..4951)
                     /locus_tag="SMD11_RS22085"
                     /old_locus_tag="SMD11_4471"
     CDS             complement(4130..4951)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_030787646.1"
                     /locus_tag="SMD11_RS22085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4471"
                     /product="tyrosinase family protein"
                     /protein_id="WP_087928085.1"
                     /transl_table=11
                     /translation="MAVRKNQATLSATEKRNFVNALLELKRTGVYDGFVRTHNEFIMSD
                     TDNGDRVGHRSPSFLPWHRRFLIQFEQELQKIDASVTLPYWDWTVDRSTTSSIWGADFL
                     GGNGRSRDSQVTTGPFAYSTGKWNINVSVDNRSYLQRELGASGQLPTRAQVDAVLAMTT
                     YDMAPWNSASDGFRNNLEGWRGQGRVHNSVHVWIGGQMATGVSPNDPAFWLHHCFIDKL
                     WADWQRMHPTSPYLPAAGTANVVDLNDTMRPWNNVTPADMLDHTKFYTYDR"
     gene            complement(5001..5351)
                     /locus_tag="SMD11_RS22090"
                     /old_locus_tag="SMD11_4472"
     CDS             complement(5001..5351)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608161.1"
                     /locus_tag="SMD11_RS22090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4472"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_234366126.1"
                     /sec_met_domain="melC (E-value: 2.8e-39, bitscore: 133.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVAGAALAAPTAMAATRTATAAMTDHSGHGGHGGPAAFDEVYQG
                     RRIVGKPATGEHAAHGGFTASIDGKELHLMQNADGTWISVVNHYETFATPLAVTRAAVD
                     KLRGATLVPIAT"
     misc_feature    complement(5581..5590)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     misc_feature    complement(5600..5614)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.79"
                     /tool="antismash"
     misc_feature    complement(5628..5642)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.07"
                     /tool="antismash"
     misc_feature    5671..5685
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.25"
                     /tool="antismash"
     misc_feature    5695..5710
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    5711..5728
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    complement(5713..5728)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(5714..5728)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     gene            complement(5827..6873)
                     /locus_tag="SMD11_RS22095"
                     /old_locus_tag="SMD11_4473"
     CDS             complement(5827..6873)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605591.1"
                     /locus_tag="SMD11_RS22095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4473"
                     /product="BadF/BadG/BcrA/BcrD ATPase family protein"
                     /protein_id="WP_234366127.1"
                     /transl_table=11
                     /translation="MGVTGASLAVDAGNSKTDVALVGPDGAVLGQARGGGFRPAVTGAG
                     AAVAGLAPLVAEAAARAGLAAPPVVEHVQACLANADLPVEERALAAEIGARGWGRSVTV
                     VNDTFALLRAGLPDDGSVAGVAVVCGAGINCAGVAPDGRTARFPAIGRISGDWGGGGFL
                     AEEALWWAARADDGRGEPSELARAVPAHFGLSGMPEVIEALHLGRVARSRCHELAPLLF
                     AVAAGGDPVARAVVARQAEEVVTMAVVALGRLGLLATRVPVVLGGGVLAARHPLLHDRV
                     VELLAERAPEAVPRVVTAPPVLGAGLLALDRARASERASEGAPREARREADREARREAH
                     TRLRAHFA"
     gene            complement(6864..8147)
                     /locus_tag="SMD11_RS22100"
                     /old_locus_tag="SMD11_4474"
     CDS             complement(6864..8147)
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179641.1"
                     /locus_tag="SMD11_RS22100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4474"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_087928087.1"
                     /transl_table=11
                     /translation="MKLTVVGGGSTYTPELVDGFARLRGTLPVTELVLVDPAADRLELV
                     GGLARRIFARQGHPGRITWTADLDAAVDGADAVLLQLRVGGQAARQQDETWPLTCGCVG
                     QETTGAGGLAKALRTVPVVLDIAERVRRRNPAAWIVDFTNPVGIVTRALLTAGHRAVGL
                     CNVAIGFQRKFARLLGVEPEAVALEHVGLNHLTWERAVTVGGRDVLPELLAEHGAAVAE
                     DLRMPRALLDRLGVVPSYYLRYFYQHDEVVRELRTKPSRAAEVAEMERRLLEMYGDPAL
                     DEKPELLGKRGGAFYSEAAVALTASLLRPEGARGAVPDARPDVQVVNAFNNGTLPFLPD
                     DAVIEVPAEVDARGARPLPVRPLEPLFAGLVANVTAYERLALEAALLGGRERVFAALLA
                     HPLIGQTERADRLTDELLAHNREHLAWA"
     gene            complement(8182..9045)
                     /locus_tag="SMD11_RS22105"
                     /old_locus_tag="SMD11_4475"
     CDS             complement(8182..9045)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982424.1"
                     /locus_tag="SMD11_RS22105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4475"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_087928088.1"
                     /transl_table=11
                     /translation="MTPTTATGPAGHRARSALRWIAVHTTAVAAALFFVLPFVFVLLTS
                     VMSDEQAMSGELWPHEWHWSNYAEVFRTPGFLTWWRNSLLYAGLGTLFTVCSSVPVAYA
                     LARFRFRGRRPAMMLVIATMMLPPQVIVIPMYLVWAQQLHLSGSLWPLIVPMAFGDAYA
                     VFLLRQFLLTIPREYLESAKVDGCGELRTLVRIVVPMAKPGIAAVALFQFFFCWNDYFG
                     PQIYAAQNPGAWTLSYGLESFKSAHSVDWNLTMAATLLVMAPVVLVFFFAQKAFVEGVT
                     LTGVKG"
     gene            complement(9050..10012)
                     /locus_tag="SMD11_RS22110"
                     /old_locus_tag="SMD11_4476"
     CDS             complement(9050..10012)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060736.1"
                     /locus_tag="SMD11_RS22110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_4476"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_087928089.1"
                     /transl_table=11
                     /translation="MATPLAHRPAPERRRGRTRERLRVLGFLSPWLIGFTVFFGYPLLA
                     TVYFSFMHYNQIQAPTFVGLRNWAYVLGRMPLFGPALWNTLWLVVVMVALRVVFGLGIG
                     LLVTKVKTGAGFFRTAFYLPYLAPPVAATVAFVFLLNPGTGPVNEALGALGIPAPNWFN
                     DPAWAKPSLVLLSLWGIGDLMVIFMAALLDVPKEQYEAAELDGAGALARFRYVTWPSIT
                     PIVTFAVVTGVVQTMQYYTQALVAGKLASGVSVGPGTVIQPGYPDGSTLTVPQLVYSLG
                     FQNFDTGAACALSLVLFAIAMAVTSLLMRGRAGLLSAED"
ORIGIN
        1 gcgcgctcca cagcatgcgg cgcgccacgt cgtggcgctc gacgaggaag gtgtcctccg
       61 cgaagccgtg ccgggaggcc ttcgcgcggt acgcgtccag ccggccgcgc agctcggccc
      121 ggacggccag cggcgccgtg acggccgtca gcgagtcacg ggcgcgcagc aactcctcct
      181 cggcgcgccg ctccaggtcc tccaggagcg gcgagagccg gtgccaccgg gcgtgtctgc
      241 ggtggtccgc cgcggccgac agctgttcgt agagctcggt cggcgggccg gagacggccg
      301 gcaccaccga tgcggcgatc ttggagagga cctcggtccg cgcctggcgg gcctcgttga
      361 gcgtgcggtc cgcgcgggag aggacgtcgc gcacccgcat cagccgctgc tcggcgtcct
      421 gccggacgtc caggacggcc tcgacctcgc ggcggacgtc ctccagggcg cgggcggcgc
      481 ggtcgtagcg gccggtgtcg gggcggccgc cgcccggcgc ggagctgggc gaggcgcctg
      541 cccagaaggc gagcggatcg gatatcacct cggtgcgcag cgccgtcagt tcctcggtga
      601 tgcgctccag gtcgtcccct gaggggtgct caccggggcg cacgcccacc gagtgggcga
      661 gcgagcgggt gcgctggagc tcggcggcga gcaggtcgat ccgggcgggc agcgccgacc
      721 agacggcgtc ggcggtgacg accacgtcga gcgcctcggc gtaccagccg ttcatccgtt
      781 cgaggagctc ctggaggctg agccgctcgc tgagccgggc ggccgggccc gccggggagc
      841 ccccggccgc ggtgggcagg tgtcccgcgc cggccagcgt gacgccgctg ccgcgcagca
      901 gctcggtgag ctcggacagc tcaccctggg tgggccagcg gcgtctgccg cgcagcgccc
      961 gcgccgcggt cagggcggag gtgtacgcgt cgaagtacgc ccacagccgg gtgatgagct
     1021 gttcggcgac ggcccaccgg ctcctggtcg cgccggtgag ttccgcgccc tccaggaggc
     1081 gacggccggc gtggtcctgg agggcgagca gcgaggactc cacggcctcg tgctccgcgc
     1141 cgagcctcgc cagcgcacgg tccacctcct cgcggctaag ggccggtccg gtggatcccg
     1201 cgaccgccat cgatcccctc tcctgtccgc ggccgtgccg cggacgtgtc cgtaacggtg
     1261 gtgcccgtcg tcccgtgccg gtgccgccgg accgtttccg tgccgccccg gcgccctccc
     1321 ggtgtcgtgc tagtcccggt acttgggcgc cggcggcgcg gtgtagccct tgaggtcggc
     1381 cgccagccac ttggtgtacg cccgcatcca cgggctgtcg ccgccgccgc tgcggtagtc
     1441 gtccagcacc ttgttgaccc ggcgtaccag gtcctcgtcc cggaggttca tcgccacgcc
     1501 gtacgggtcg gtggtgaacg gctttccgac gagctccacg gacgggtcct gggcggccag
     1561 accggccccc agggcgttgt ccgtgagcac cgcgtccacc tggccgagtt ggagccggac
     1621 caggcagtcc agctggttgg gcacggtgac caggcgcgcg ccgtgcggct gttccctcat
     1681 cttcgactcc gctgtggccc ccttggccgc acagaccttc ttccccttca gggagtcgtc
     1741 gaacgcggtg acggaagacc ccctcggggc aagtatctgc tggccggcga cgaagtatgc
     1801 ggtggagaag gcgacttgtc ggatccggtc gcaggtgatg gacatggtgc gcgcgatgag
     1861 atcgaccttg cccttttcca gggcggggat gcgctggctg gtggggatcg ccaggaaggt
     1921 caccttgtcg gcgtcgccca ggatgtcctt ggcgatcgcg cgcgtcaggt cgatgtcgaa
     1981 gccgctgagc tcgccggtgg acggattgcg gtagccccag cggaagctgt cctggtcgac
     2041 gcccgcgatc agccgcccac ggctcttgat ccggcgcacc gccgggccgt ccgcgccgtc
     2101 ccccgggcgc aggctcgcct cggggtcggt gcaggtcgcg ggcgccgcgg cggctcggtc
     2161 cgcccggtcg gccacggtgg tgacgcggtg ctccgccgtg ccggccggca ccagcgcggc
     2221 ggccgtggcc gcgagcgcgc acccggccgc agccgtggcc agggcgagcg accggccgcg
     2281 cgaaatcctc gggacgtccg gtgacttcgg cccctgggtg gccttcggtt ccggtggcac
     2341 ctccggtcgc gccagcacct gctgtcccgc ccgccgcgcc cgtatcgccc gtaccaaccg
     2401 gcccgttcgc cccggctgcc cgtgtgcccg cccgtgctcc tgccccgtca cgtgcccgcc
     2461 tccccccgtc accggtactc cgacagtctg cgcccgatcc ccagcaccgc gcccgccgcg
     2521 ccgagcaccg ccagcaccac ggcccccgcc gccagcccgg ccagggctcc gcgcccgtcg
     2581 tccgccgccg cccggaagtc gcgctgctca tgggccaggg cccggcggag ttgctcgtcc
     2641 acccggtcga aggactcgcc cgtgctgccc ttctcgccga tcaccttcgg cagcgcccgg
     2701 tcgtagtccc cgctgtcgtc cgccgcgcgc gcctcggcgt gccgcacctg ccactcgcgg
     2761 acgtccctga cggcggcgtc gaccgccgcc cggccctcgg agtcctcggc gagtgcccgc
     2821 gcccgcgcca gcagcgtgcc cggcgcggcg gcgccgcggc cgtcgccgac gagcttgcgc
     2881 atgccctcgc ggtagctcgc ctcgtacgcg tcgtccttgt tctccgtgag caccgcgccg
     2941 cgcgcgacca gcgtgaggtt ctcgtcgccg cgcgcctgga gcgagccgat gcgggcctcg
     3001 ttgagcacct ggagcgaccg ggcgccctgg gccgaggagc cctccaggtc cgagcgggcc
     3061 agggcgtgcc cgacggtcag ccagagcagc accaccacgg ccgtcgcggt ggcggccagc
     3121 atcccgtggt tgaagacgcg gtgggtgcgg aggtaggtgc gccgctgcgc ccagccgagc
     3181 gcgccgaggg cggccaggcc gaggaccagc gaggcccagg gccaggcctt ggcgtcggag
     3241 tagtcggagc cgagccgtcc ggtctcggtc tcgtagagct cgcgggcggc gggcagcagg
     3301 tcgtcgcgca tcaggtcgcc ggcggtgcgc agataggcgc cgcccagcgg gaggccctgc
     3361 cggttgttgg cgcgggcgga ctccacgagg ccggtgtagc gcgggaggag ttcgttcagc
     3421 cgcgagatct gccggcgggc ggtgtcggag ccctcggcgt tggccgcggc cttcaccagc
     3481 aggccggccg ccagcgcgat gtccttctcg taccgctgcc ggacggcggg ggtctcccgg
     3541 gagccggcga ggaagccgct ggcggccgtg gtgtcggcgt cggccaggga gcggtagacg
     3601 tcggcggcgt cggcgctgag cggctggctg ctgcccacca cggcgtcggc ggccgaggcc
     3661 cggtccgcga cctgccaggc ggtcaccgcg ccgaacgcga cgagcagcag ggccaggagg
     3721 gcgccgatgg cgcgcagccg gcccggctcg gtcgtggcca cggcccgcag gcggtcggcc
     3781 gcttcccgcc aggcggcggg cagggcgggc gtgggcggtg gcggcgcggc gccaccggcc
     3841 ggctgcgggt atgacacggg acctccccct cggtcgctgt ggacgcccgt tcccccggcc
     3901 ggccgggccg gccccggacg aacagcagcc ccggccagca gtatggccgc aggagctgac
     3961 aaacacaccg gtaccggccc gatcttgttc tgatcgcgat ccgcaccggg gcccgcaccg
     4021 gcctccgtac ccaccacgcg cgacgggccc gtccggttcc cgcgcgggtg ggcggggaac
     4081 cggacgggcc cgtggggcac cgtcacgctg cgcggggccg gaccggccgt cagcggtcgt
     4141 aggtgtagaa cttcgtgtgg tccagcatgt cggccggggt cacgttgttc caggggcgca
     4201 tggtgtcgtt gaggtccacg acgttcgcgg tgccggcggc cggcaggtag ggcgacgtcg
     4261 ggtgcatgcg ctgccagtcg gcccacagct tgtcgatgaa gcagtggtgc agccagaagg
     4321 cggggtcgtt gggggagacg ccggtggcca tctggccgcc gatccacacg tggacgctgt
     4381 tgtggacgcg gccctggccg cgccagccct ccaggttgtt gcggaagccg tccgaggcgc
     4441 tgttccaggg agccatgtcg tacgtggtca tggcgagcac ggcgtcgacc tgggcgcgcg
     4501 tgggcagctg gccgctggca cccagctcac gctggaggta cgagcggttg tcgacgctga
     4561 cgttgatgtt ccacttgccc gtggagtacg cgaacgggcc ggtggtcacc tgggagtcac
     4621 ggctgcggcc gttgccgccg aggaagtcgg cgccccagat cgaggacgtg gtcgagcggt
     4681 cgacggtcca gtcccagtac gggagggtga ccgaggcgtc tatcttctgg agctcctgct
     4741 cgaactggat caggaagcgg cggtgccagg ggaggaacga gggggaacgg tggccgacgc
     4801 ggtcgccgtt gtccgtgtcg ctcatgatga actcgttgtg cgtccgcacg aatccgtcgt
     4861 agacgccggt gcgcttgagc tccagcaagg cgttgacgaa gttgcgcttc tcggtggcgc
     4921 tcagcgtcgc ctggttctta cgcactgcca tgggggttct gtcctctcgg gtcgggtcgg
     4981 tggaacggca gagcggtgac tcaggtggcg atcgggacga gcgtggcgcc gcggagcttg
     5041 tcgacggcgg cgcgggtcac ggcgagcggg gtcgcgaacg tctcgtagtg gttcacgacg
     5101 ctgatccagg tgccgtcggc gttctgcatc aggtgcagtt ccttgccgtc gatcgaggcg
     5161 gtgaagccgc cgtgcgcggc gtgctcgccg gtcgcgggct taccgacgat gcggcgcccc
     5221 tggtagacct cgtcgaacgc cgcgggtccg ccgtggccgc cgtggccgga gtggtcggtc
     5281 atggcggccg tggccgtacg ggtcgcggcc atggcggtcg gcgcggcgag cgcggcgccg
     5341 gcgacggcca cggcggttcc tctgagcaca aggcgtcggg tgacgttgga cgacatgggt
     5401 cgtacccccc tcggaaggat gatcaggagc aggaattgat cgcgaatgcc cccgcaaatc
     5461 ccttttgatg gcggttgctt cccgtatttc gtgatcaatc cgtgcggccc ggatgcttgc
     5521 acgccgccga ggagggcgcg aaatggttgg ctgctttacg gacattcggt acatgaaagg
     5581 tcaacaaatg ccaggggagg aatttctggc gaatgaccgt attgacgcag tgtcaggaaa
     5641 atccgcgccc ggacgggatc tcgtaaggag attttgcgga atatcctggt ccggggtgac
     5701 gcctctcacg atgtgaacat gacgtgaaga gtgcggtggt tccgtggaat ccagccaggt
     5761 gggacggcct tggtcgtaaa gggccgaggc ggtcccggaa gaggcgggac cgccacccgc
     5821 ggagacctac gcgaagtgcg cgcgcaaccg cgtgtgtgct tcccgacgtg cctcccggtc
     5881 tgcctcccga cgcgcttccc gcggcgcccc ctccgacgcc ctctccgaag ccctcgcgcg
     5941 atccagcgcc agcagccccg cgcccagcac cggcggggcc gtgaccaccc ggggcacggc
     6001 ctcgggcgcc cgctcggcca gcagctccac cacccggtcg tgcagcaagg ggtgacgggc
     6061 cgccagcacc ccgccgccca ggaccaccgg cacccgcgtg gccagcagcc ccagccggcc
     6121 cagcgccacg acggccatcg tgacgacctc ctccgcctgc cgggcgacga ccgcccgcgc
     6181 gaccgggtca cccccggcgg ccaccgcgaa cagcagcggc gccagctcgt ggcaccggct
     6241 ccgcgccacc cggcccaggt gcagcgcctc gatgacctcc ggcatcccgg acagcccgaa
     6301 gtgcgcgggc accgcccggg ccagctcgct cggctcgccc cggccgtcgt ccgcgcgcgc
     6361 cgcccaccac agcgcctcct ccgccaggaa cccgccgccg ccccagtcgc ccgagatccg
     6421 cccgatcgcc gggaaacgcg cggtccgccc gtccggcgcc acgcccgcgc agttgatgcc
     6481 cgccccgcac accacggcca cgcccgccac cgacccgtcg tcgggcaggc ccgcccgcag
     6541 cagggcgaag gtgtcgttga cgaccgtgac cgagcggccc cagccccggg ccccgatctc
     6601 cgcggccagc gcccgctcct ccaccggcag atcggcgttg gccagacagg cctggacgtg
     6661 ctccaccacc ggcggcgccg cgagcccggc ccgcgccgcc gcctccgcga cgagcggcgc
     6721 gaggcccgcg acggccgccc cggcgcccgt caccgccggc cggaagcccc cgccccgcgc
     6781 ctgccccagc acggcgccgt cggggcccac cagcgccacg tcggtcttgc tgttgcccgc
     6841 gtcgacggcg agcgacgcac cggtcacgcc cacgccaggt gctcccggtt gtgcgccagc
     6901 agctcgtcgg tcagccggtc cgcccgctcg gtctgcccga tcagcggatg cgcgagcagc
     6961 gcggcgaaca cccgctcgcg gccccccagg agcgccgcct ccagggccag ccgctcgtag
     7021 gccgtcacgt tcgcgaccag cccggcgaac agcggctcca gcggccgcac cggcagcggg
     7081 cgggcgccgc gcgcgtccac ctcggccggc acctcgatca ccgcgtcgtc ggggaggaag
     7141 ggcagcgtcc cgttgttgaa cgcattgacc acctgtacgt ccggccgtgc gtccggcacg
     7201 gctccccggg cgccctcggg acgcagcagc gaggccgtca gcgccaccgc cgcctccgag
     7261 tagaaggcgc cgccccgctt ccccagcagc tccggcttct cgtccagcgc cgggtcgccg
     7321 tacatctcca gcagccgccg ctccatctcc gccacctcgg cggcccgcga gggcttggtc
     7381 cgcagctccc gcacgacctc gtcgtgctgg tagaagtagc gcaggtagta cgagggcacc
     7441 acgccgagcc ggtccagcag cgctcgcggc atccgcaggt cctcggccac ggccgcgccg
     7501 tgctcggcga gcagctccgg cagcacgtcc cggccgccga ccgtcaccgc ccgctcccag
     7561 gtcaggtggt tgagcccgac gtgctccagg gcgaccgcct ccggctccac ccccagcagc
     7621 cgggcgaact tccgctggaa gccgatcgcg acgttgcaca gcccgacggc ccggtgcccg
     7681 gcggtgagca gcgcccgggt cacgatcccc accgggttgg tgaagtccac gatccacgcg
     7741 gcggggttgc gccgtcgcac ccgctccgcg atgtccagca cgaccgggac cgtgcgcagc
     7801 gccttggcga ggccgcccgc gccggtggtc tcctgtccga cgcagccgca ggtcagcggc
     7861 caggtctcgt cctgctgccg ggccgcctgg ccgcccacgc gcagctggag caggacggcg
     7921 tcggcgccgt ccacggccgc gtccagatcc gcggtccagg tgatccggcc ggggtggccc
     7981 tgccgggcga agatccgccg ggccaggccg cccaccagct ccagccggtc ggccgccggg
     8041 tcgacgagga ccagctccgt caccggcagc gtcccgcgca gccgggcgaa tccgtcgacg
     8101 agttcggggg tgtaggtcga gcctccgccg accacggtga gtttcatgcg gacctcagtt
     8161 ccataggggc ctcatggggg ttcagccctt cacgccggtg agggtgacgc cttcgacgaa
     8221 ggccttctgt gcgaagaaga agacgagcac gaccggggcc atgaccagca gcgtcgccgc
     8281 catggtcagg ttccagtcga cgctgtgcgc gctcttgaag gactccagcc cgtaactgag
     8341 cgtccaggcg cccgggttct gcgccgcgta gatctgcggc ccgaagtagt cgttccagca
     8401 gaagaagaac tggaacagcg cgaccgcggc gatcccgggc ttcgccatcg gcaccacgat
     8461 ccgcaccagg gtgcgcagct ccccgcatcc gtccaccttc gccgactcca ggtactcccg
     8521 ggggatcgtg agcaggaact gccgcagcag gaatacggcg taggcgtcgc cgaacgccat
     8581 cggcacgatc agcggccaca gcgaccccga gaggtgcagc tgctgcgccc acaccaggta
     8641 catcggaatg acgatcacct ggggcggcag catcatcgtg gcgatcacga gcatcatcgc
     8701 gggccgccgg ccacggaagc ggaacctggc cagcgcgtag gccaccggga ccgaggagca
     8761 caccgtgaag agggtgccga gccccgcgta gagcagggag ttgcgccacc aggtgaggaa
     8821 gcccggggtg cggaagacct ccgcgtagtt cgaccagtgc cactcgtgcg gccacagctc
     8881 gccgctcatc gcctgctcgt cgctcatcac ggaggtcagc aggacgaaga cgaaggggag
     8941 gacgaagaac agggcggcgg ccacggcggt ggtgtggacc gctatccagc gcagggcgga
     9001 gcgggcgcgg tgccccgccg ggccggtggc tgtcgtgggg gtcacggcct cagtcctccg
     9061 cgctcagcag gccggcgcgg ccgcgcatca gcagggaggt gacggccatg gcgatcgcga
     9121 agaggacgag cgagagcgcg cacgcggcac cggtgtcgaa gttctggaag ccgagcgagt
     9181 agacgagctg cggcacggtg agcgtcgagc cgtcggggta accgggctgg atcaccgtgc
     9241 ccggcccgac gctgacgccc gaggcgagct tcccggcgac cagcgcctgc gtgtagtact
     9301 gcatggtctg cacgacgccc gtcaccaccg cgaacgtcac gatcggggtg atcgacggcc
     9361 aggtgacgta ccggaaccgt gcgagggcgc ccgcgccgtc cagctcggcg gcctcgtact
     9421 gctccttggg cacgtccagc agggcggcca tgaagatgac catcaggtcg ccgatgcccc
     9481 acagcgagag cagcaccagg gagggcttgg cccaggccgg gtcgttgaac cagttcggcg
     9541 cggggatccc cagggcgccg agggcctcgt tgaccgggcc cgtgccgggg ttgaggagga
     9601 agacgaaggc cacggtcgcg gccacgggcg gggccaggta gggcaggtag aaggcggtgc
     9661 ggaagaaccc ggcgcccgtc ttcaccttgg tgacgagcag gccgatgccc aggccgaaga
     9721 ccacccgcag ggcgaccatc accacgacga gccagagggt gttccacagc gcggggccga
     9781 acagcggcat ccggcccagc acataggccc agttccgcag gccgacgaag gtcggcgcct
     9841 ggatctggtt gtagtgcatg aaggagaagt agacggtggc gagcagggga tagccgaaga
     9901 agacggtgaa gccgatcagc cacggcgaga ggaagccgag gacgcgcagc cgctcgcggg
     9961 tgcgtccgcg gcgtcgttcg ggtgccggcc ggtgggccag gggtgtcgcc atggcgtact
    10021 ccgtcagttc cgggactgga ggttgtcttc gtctatctgc cggtcgagac ggcgcaggcc
    10081 cttcttcagg tcgggcaccc ggcccgcctc cgctctgaag gcgaagtcgc ggagcgagag
    10141 gacgtacctc ccgccgttga cggacggggg catgctgacg ctgcgcgggt gccgcgcgat
    10201 gccgaggaag gtgcggaagg cggggtcgcg cgccagctcc ggtgaggcga gcgcggcctt
    10261 ggtcgagggc acgttgtgga tggcgttggc gaaggcgacc acctgagagg tgtcggcggt
    10321 caggaaccgc accagctccc acgcggcgtt c
//
