LOCUS       NZ_CP021744            20267 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces albireticuli strain MDJK11 chromosome, complete genome.
ACCESSION   NZ_CP021744
VERSION     NZ_CP021744.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces albireticuli
  ORGANISM  Streptomyces albireticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Streptomyces albireticuli Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2017) Department of Mcrobiology, Shandong
            Agricultural University, No.61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 2.3
            Expected Final Version            :: yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 07:12:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,975
            CDSs (total)                      :: 6,876
            Genes (coding)                    :: 6,711
            CDSs (with protein)               :: 6,711
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 165
            CDSs (without protein)            :: 165
            Pseudo Genes (ambiguous residues) :: 0 of 165
            Pseudo Genes (frameshifted)       :: 74 of 165
            Pseudo Genes (incomplete)         :: 97 of 165
            Pseudo Genes (internal stop)      :: 5 of 165
            Pseudo Genes (multiple problems)  :: 9 of 165
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:17:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3252669
            Orig. end                         :: 3272936
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021744.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20267
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="20"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20267
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20267
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10267](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10267
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(94..1080)
                     /locus_tag="SMD11_RS13670"
                     /old_locus_tag="SMD11_2787"
     CDS             complement(94..1080)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="SMD11_RS13670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2787"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_087926734.1"
                     /transl_table=11
                     /translation="MPQTPTDLRIGVVLPGRESVVERNDYPRHLGELSRKIEQLGYDSI
                     WAGESPLARSRMNPVLALTAAATTTERVQLGTAVLLPLRPPVHLAHELACLDRISGGRL
                     ITGLGSGFSSPATRAEFAAYGIPFDQRVGRTRETLEICRALWRAEGEPVSFAGKYYRLD
                     DVALLPVPDQPAGPPLWMAHSGEKMLERTGRIYDGWMPTSTTAAHYEKGWLRVQEAREA
                     AGRPESDVTGAVYLSVAVDRGVEKAEETLTAYFGAYYRLDLPTMRTTQGIFGGTPEQVA
                     EWVGGYVAAGARHIVLRLPTPDLHEPAYRAALERTAEELLPLLRGLA"
     gene            complement(1129..2316)
                     /locus_tag="SMD11_RS13675"
                     /old_locus_tag="SMD11_2788"
     CDS             complement(1129..2316)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611471.1"
                     /locus_tag="SMD11_RS13675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2788"
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_087930485.1"
                     /transl_table=11
                     /translation="MNESLAVAGAPAPAVWDLLPAEQQPRWGAHPDLPEVRRALQEAPA
                     LTSAADVSVLRRQLAEVALGRARLLQTGDCAEDIRECGAAHTAAKAELLADLAGRMALR
                     TGQPVVRVGRMGGQFAKPRSSPTETHDGVDLPVFRGHLVNSPEPHAAARRHDPNRMLRA
                     YEASAAVLRALDELRTDAYGPWASHEALVMDYESPQVRRDPETGAPYLASTHFPWIGER
                     TRQLGLAHVEFLASLANPVACKIGPSASAEQVVRLCRVLDPDRLPGRLTLILRTGVRTP
                     ASAVAPVVEAVQRAGHPVVWLSDPLHGNTVQTAGGVKTRRLADAVGEAAAFRRVLEQRG
                     LHPGGLHLETATADVTECLGGPVADEHALSGRYESLCDPRLNPAQARELIDAVFS"
     gene            complement(2313..3341)
                     /locus_tag="SMD11_RS13680"
                     /old_locus_tag="SMD11_2789"
     CDS             complement(2313..3341)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04444.1"
                     /locus_tag="SMD11_RS13680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2789"
                     /product="FkbO/Hyg5 family chorismatase"
                     /protein_id="WP_087926735.1"
                     /transl_table=11
                     /translation="MSQHAGLQAHFTSLDGIPQPAPGRHVLGTVAFGERTGLALTGQGY
                     PELTIPMASPGFDSFREVWTTGTAPRSGTRGSLAFAHDGEYLFISGALPPLPVYRTTVR
                     EVYEAAFALVNELGYPHIFRMWNFVGDIIGPNAEGMEIYQDFVAGRAEAFASYGDGTGH
                     MPAATGIGTRGEGISFTLLACREGRPRHVENQRQTPAYHYPEQYGPKPPSFARATRLHP
                     AGAGQGDGALFVSGTASILGHETVHRGDVAAQTDVVLENIAELISGPNLAAAGLDGGHE
                     LKDLRLVKVYVRHEADLPVVRERCRSAFGPDTEVMYMNVAVCRDDLLVEIEGLVPGPEW
                     TR"
     misc_feature    complement(3321..3323)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3698..3713
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.47"
                     /tool="antismash"
     misc_feature    4213..4231
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.02"
                     /tool="antismash"
     misc_feature    complement(4214..4232)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.13"
                     /tool="antismash"
     gene            4239..4508
                     /locus_tag="SMD11_RS13690"
                     /old_locus_tag="SMD11_2791"
     CDS             4239..4508
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089841.1"
                     /locus_tag="SMD11_RS13690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2791"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_087926737.1"
                     /transl_table=11
                     /translation="MMEFDPTLPKWTQIAQVIRQRIASGEYAPNHLVSETQLEQEFDVA
                     RVTVRKVTRALREEGLIVTTHGMGSFVTEQAAGIIKASKDPSAG"
     gene            complement(4497..5303)
                     /locus_tag="SMD11_RS13695"
                     /old_locus_tag="SMD11_2792"
     CDS             complement(4497..5303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998016.1"
                     /locus_tag="SMD11_RS13695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2792"
                     /product="hypothetical protein"
                     /protein_id="WP_234366029.1"
                     /transl_table=11
                     /translation="MRTRHDHAARALAVTLGGGEERWGWAGRTLGRPGVTGDGRRVWLR
                     LVSAPAGKASGKTWEGATDAQQAFGDLHGHRPALLAVHDEAEDGTVHRAELSEHLDQDV
                     ISDDPVLRVPDGLPAAWWTALGSALGTVADVTTDRIAVRQEYIHRALPEFLGVPAPDAI
                     TWTTAHGDLHWANLTAPGLRILDWEGWGRAPYGYDQATLYAYSLLRPATAARVRAAFPD
                     LDAPQTWTGQAVIAAELLQTLSRGDNHELAGPLHEWADRLRARSPR"
     gene            complement(5502..6725)
                     /locus_tag="SMD11_RS13700"
                     /old_locus_tag="SMD11_2793"
     CDS             complement(5502..6725)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (66-405). E-value:
                     4e-50. Score: 162.9. Matches aSDomain:
                     nrpspksdomains_SMD11_RS13700_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985835.1"
                     /locus_tag="SMD11_RS13700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2793"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_087926738.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.2e-54, bitscore:
                     183.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 1.3e-153, bitscore: 510.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTNESAAVTGLGATTPLGGDIASTWEAMLRGESGIRAIEDDWA
                     AELPVRIAGRLRQEPAGLLDRVQARRMDRCEQIALLAAREAWADAGRPEVEPERLAVVI
                     GTGTGGVLTLLGQDDVLEASGVRKVSPHTVPMLMANGPAAWVSMELGARGGAHTPVSAC
                     ASGAEAIAMGLDLIRLGRADVVVAGGTEACVHPLPIAGFAQAKAHSTRNDDPAGASRPF
                     DTGRDGLVIGEGAGVVVLERAGFAAARGARPHAVLAGAGVTSDAHHITAAHPEGQVRAM
                     RLALSAAGLTPADIAHVHAHATSTQLGDLVEARSVAEAIGTHPSVTATKSMTGHLFGAA
                     GAIGAIAAILAVRDGAVPPVRNLVDLDPEVPLDVVAGSPRHGRVPAALANAFGFGGHNA
                     SLVFTAAG"
     aSDomain        complement(5511..6527)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SMD11_RS13700_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.00E-50"
                     /label="SMD11_RS13700_PKS_KS.1"
                     /locus_tag="SMD11_RS13700"
                     /protein_end="405"
                     /protein_start="66"
                     /score="162.9"
                     /tool="antismash"
                     /translation="VQARRMDRCEQIALLAAREAWADAGRPEVEPERLAVVIGTGTGGV
                     LTLLGQDDVLEASGVRKVSPHTVPMLMANGPAAWVSMELGARGGAHTPVSACASGAEAI
                     AMGLDLIRLGRADVVVAGGTEACVHPLPIAGFAQAKAHSTRNDDPAGASRPFDTGRDGL
                     VIGEGAGVVVLERAGFAAARGARPHAVLAGAGVTSDAHHITAAHPEGQVRAMRLALSAA
                     GLTPADIAHVHAHATSTQLGDLVEARSVAEAIGTHPSVTATKSMTGHLFGAAGAIGAIA
                     AILAVRDGAVPPVRNLVDLDPEVPLDVVAGSPRHGRVPAALANAFGFGGHNASLVFTA"
     gene            complement(7017..7997)
                     /locus_tag="SMD11_RS13705"
                     /old_locus_tag="SMD11_2794"
     CDS             complement(7017..7997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357457.1"
                     /locus_tag="SMD11_RS13705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2794"
                     /product="hypothetical protein"
                     /protein_id="WP_087930487.1"
                     /transl_table=11
                     /translation="MPGAAVARAADGAAAETPKSFTITDPRIRESSGLAASRAHPGVYW
                     THNDSDDGPYVYAVDSRTGRTVATVTLADIDPRDVEGISIGPDGNIYVGDIGDNYGGRW
                     QEVWIYRFPEPKKLADTTVTPVRHTVRYDDGPRDAESLMVHPRTGRVYIVSKKQSGKSA
                     LYAGPEKLSASGVNTFRRVADIDVWATDGAFSPDGTRLVVRSYFDAREYRWRDGRPEEV
                     GRPGVPLQRQGESVTFAPDGRTLMYGSEGRRSSVQPVGLDGDLLPDSVAKAPDDARNGG
                     GASSDGKSGDGTDEGDRNRNLAVGAGTFAVATLLVVSLRRLFRRK"
     gene            8339..9481
                     /locus_tag="SMD11_RS13710"
                     /old_locus_tag="SMD11_2795"
     CDS             8339..9481
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016908684.1"
                     /locus_tag="SMD11_RS13710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2795"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_087926739.1"
                     /transl_table=11
                     /translation="MEYNGWADEGFGAVADAFGRNFTDHGDTGAAVTVFVDGRKVVDLW
                     GGTADERTGRPWERDTAVPVMSAAKGVVAVCAHLLAQEGRLDLDAPIADHWPEFARHGK
                     ERITPRMVLAHRAGLPVIDRPLTFEEILAWTPVVRALEEQAPYWEPGTAHEYHGHTMGW
                     LIGEVIRRITGRTPGAYFRTAVADELGLTTWIGVPEAELPGLARLSEAPGTYPELPAES
                     LFARILTMDGALPFPGTDHPRGRNSPAVLAAEIPGTGAVSSARGLATLYAAAATGVDGA
                     PRLLTRDTLTDALRVRTDGPSWSGFPDGGVHWGSGFNVASESVPLLGARSFSNEGAGGH
                     FALGDDELGVGFAYVTNRMVGGEDPRGPLLVGAVRGCVAG"
     gene            9886..9990
                     /locus_tag="SMD11_RS34920"
                     /old_locus_tag="SMD11_2796"
     CDS             9886..9990
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="SMD11_RS34920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2796"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_107421954.1"
                     /transl_table=11
                     /translation="MEPQESYEPPALEELGDFSELTRGRPAAEAAEDV"
     gene            10001..10267
                     /locus_tag="SMD11_RS13715"
                     /old_locus_tag="SMD11_2797"
     CDS             10001..10267
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lasso_Fused_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123202.1"
                     /locus_tag="SMD11_RS13715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2797"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_087926740.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4e-23,
                     bitscore: 79.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 6.6e-08,
                     bitscore: 31.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-11, bitscore: 43.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLTLHPDVSAADTEDGMVLLDEVGGRYWQLNGTGATVLRALLD
                     GATPGEVARSLAERYPGLTTERTNSDVAALIISLSEARLVVTA"
     aSDomain        10004..10258
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SMD11_RS13715_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.60E-25"
                     /identifier="RREFam002.1"
                     /label="SMD11_RS13715"
                     /locus_tag="SMD11_RS13715"
                     /protein_end="86"
                     /protein_start="1"
                     /score="79.9"
                     /tool="antismash"
                     /translation="SVLTLHPDVSAADTEDGMVLLDEVGGRYWQLNGTGATVLRALLDG
                     ATPGEVARSLAERYPGLTTERTNSDVAALIISLSEARLVV"
     gene            10264..10770
                     /locus_tag="SMD11_RS13720"
                     /old_locus_tag="SMD11_2798"
     CDS             10264..10770
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF13471"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640867.1"
                     /locus_tag="SMD11_RS13720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2798"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_087926741.1"
                     /sec_met_domain="PF13471 (E-value: 1.3e-26, bitscore: 91.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPMVLEPREPVPLRRRPAALLAVGAARLLVLLPPRRIRRALTL
                     ARRGAAPATAEEALAARRAVVALSARCAGEGCLQRSMATALLCRMRGVWPDWCTGVRTS
                     PFRAHAWVEVAGLPIGESHSPGYYHRLMVVPGGGPGGRPGTGPGRREPRAAVTAPGAAA
                     VTGPA"
     gene            complement(10754..11329)
                     /locus_tag="SMD11_RS13725"
                     /old_locus_tag="SMD11_2799"
     CDS             complement(10754..11329)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SMD11_RS13725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SMD11_2799"
                     /product="hypothetical protein"
                     /protein_id="WP_087926742.1"
                     /transl_table=11
                     /translation="MISKLSTTATARRATTRRVLTGAAAAGVLALMLAPAGPGAAAAGG
                     SGKSAGEGKDAAVVLRCHGSLRMDVKPNGEATGVGRLTCDAPSRSRIESATLTMKGRAT
                     GGSGPDVVTTTDDHVVYNTNEVSDLKADRTFTRLDPGRTEARQAGTGTVVRNLFSPARQ
                     EGNGSGRVFVGIAATSWFIDDVSFTLDR"
     misc_feature    complement(11315..11317)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11332..11347)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     misc_feature    11659..11673
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
     gene            11667..12104
                     /locus_tag="SMD11_RS13735"
                     /old_locus_tag="SMD11_2800"
     CDS             11667..12104
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008737940.1"
                     /locus_tag="SMD11_RS13735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2800"
                     /product="VOC family protein"
                     /protein_id="WP_087926744.1"
                     /transl_table=11
                     /translation="MFTNTKAFSGFAVDDIERAKDFYHRTLGLRVTEEFGLLTLHITGG
                     TEILVYPKPDHTPASFTVLNFPVDDIDRAVDELTSRGVRFERYEQFEQDEKGVFRQEGP
                     PIAWFTDPAGNVLSVLQAAGPHPARKAYSLTVCGSCSSATR"
     gene            12074..12763
                     /locus_tag="SMD11_RS13740"
                     /old_locus_tag="SMD11_2802"
     CDS             12074..12763
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006348580.1"
                     /locus_tag="SMD11_RS13740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2802"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_087926745.1"
                     /transl_table=11
                     /translation="MRIMFVGDSMTIGSAGDYTWRYRMWQHLNASYGGPYRIVGPRTEL
                     YDPSVDAPGSLAYGDAAFPARAQAHLAGWGEGWLHMAPLIGDAVRAGKADTLLISLGLI
                     DLGFYTDAEQTAENVHRFLAAAREANPRVRAVLLPVIHNVRALNDPPFAAQCERFNELL
                     GKAVAELDSPASPLLLASPPEGWDIDRDTYDGTHPNAEGEHRLAAAFADAMHQAWDVAG
                     PYEPARG"
     gene            12894..13880
                     /locus_tag="SMD11_RS13745"
                     /old_locus_tag="SMD11_2803"
     CDS             12894..13880
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643315.1"
                     /locus_tag="SMD11_RS13745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2803"
                     /product="aldo/keto reductase"
                     /protein_id="WP_087926746.1"
                     /transl_table=11
                     /translation="MEYTQLGRTGLKVSRIVLGTMNFGPRTDEADSHAIMDAALDAGVN
                     FFDTANVYGWGENKGRTEEIIGSWLARGGGRREKVVLATKVFGNMGPDGADWPNHDRLS
                     AVNIRRAVDASLQRLRTDHIDLYQFHHVDRTTPWDEIWQAIDVLVQQGKIVYAGSSNHA
                     GWHIAQANEAARRRGSYGLVSEQCLYNLAERRAEMEVVPAAEAYGLGVIPWSPLQGGLL
                     GGVIRKEREGGGAAGRSSEALANTKVREQVQAYEDLLDKHGLEPGEVALAWLLTRPGVT
                     GPIVGPRTGEQLSSALRAVELKLPEELLTELDGIFPGPGPSPEAFAW"
     gene            complement(14100..14663)
                     /gene="thpR"
                     /locus_tag="SMD11_RS13750"
                     /old_locus_tag="SMD11_2805"
     CDS             complement(14100..14663)
                     /GO_function="GO:0008664 - 2'-5'-RNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="thpR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981859.1"
                     /locus_tag="SMD11_RS13750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2805"
                     /product="RNA 2',3'-cyclic phosphodiesterase"
                     /protein_id="WP_087926747.1"
                     /transl_table=11
                     /translation="MRLFAAVIPPPQAVAELEAALAPLHGLPGAAHLRWTEPATWHFTL
                     AFLSEVDEALLPGLGERLARAAHRHPPHPLRLAAAGRFDDKILWVGAEGELTTLRDLAR
                     STAAGARRAGVEVDGKHPFRAHLTLARAAGPVRLGPYEEHLADFAGTPWTVDRLALVRS
                     TLPASGVPGERPRYTTVASWGLGR"
     gene            complement(14792..16177)
                     /locus_tag="SMD11_RS13755"
                     /old_locus_tag="SMD11_2806"
     CDS             complement(14792..16177)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981858.1"
                     /locus_tag="SMD11_RS13755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2806"
                     /product="MFS transporter"
                     /protein_id="WP_087926748.1"
                     /transl_table=11
                     /translation="MSTGPGADSAPAPKAHDDDTRTALTESLTKNKGGTFSSLRIRNYR
                     LFATGQVVSNTGTWMQRIAQDWLVLGLTGSSAAVGITTALQFLPMLLLGLYGGVIADRY
                     PKRLLLLITQVAMGFTGLALAVLTLSGHVEVWHVYVTALVLGLVTVVDNPARQAFVVEM
                     VGPDDLRNAVSLNSANFQSARLVGPAVAGVLITAVGSGWAFLLNGLSFVAPVVGLLLMR
                     TSELHKVERAPRGKGQLREGLRYVAGRPDLVWPIVLVGFIGTFGFNFPIWLTAYVNDVF
                     HAGAGTYGLLNTLMAAGSLVGALLAARRGNSRLRLLVGAALLFGVLEITAALAPSFWVF
                     AALLAPIGMCGLTINVTANSSLQMATDPAMRGRVMSLFMMVFMGGTPIGAPLVGYVTDV
                     YGARVGFLAGGVVSLLAATGVGMALARVGGLRLKIDLRRGHTHVAFVPRQPLREPAAVT
                     TAA"
     gene            complement(16207..16644)
                     /locus_tag="SMD11_RS13760"
                     /old_locus_tag="SMD11_2807"
     CDS             complement(16207..16644)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887305.1"
                     /locus_tag="SMD11_RS13760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2807"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_087930488.1"
                     /transl_table=11
                     /translation="MSDPDPQVDTAAVDSLRSGVMRLSRRLKHQRVDESLSPTEMSVLG
                     TLARCGTATPGELARKEHVQPPSMTRIVALLEAKGLVRLEPHPEDRRQKVVTQTERAEA
                     MLEESRRKRNVWLTELVGQLDEDEWATLRAAAPVLEKLAHL"
     misc_feature    16692..16701
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(16715..16724)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    16739..16757
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.36"
                     /tool="antismash"
     gene            complement(16806..18275)
                     /locus_tag="SMD11_RS13765"
                     /old_locus_tag="SMD11_2808"
     CDS             complement(16806..18275)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089675.1"
                     /locus_tag="SMD11_RS13765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2808"
                     /product="NCS2 family permease"
                     /protein_id="WP_087926749.1"
                     /transl_table=11
                     /translation="MPSSATSPVDAQQPAPVPPPGNPLDRYFRITERGSSITRELRGGL
                     ATFFAMAYIIVLNPIILGAGQDKFGHQLDNAQLVTATALMAGLTTVLMGAIGNVPIACA
                     AGLGINAVVSLQLAPKMSWPDAMGMVVLAGLVLMLLVASGLRQRVMDAIPGGLRRAIAI
                     GIGLFISLIGLVDSGFVTRNPDAAHTTVPLGLGQGGQLHGWPVLIFAIGLALTFILVVR
                     KTSGAILIGIVVMTFVAVVINTLIEIPDANWGLSVPRMPDSVVGAPDFGLVGDISLFGG
                     FHEVGLLTGCLFVFTVLLSGFFDAMGTIIGVGEEAGLTDKNGQLPNMGKILMVDGVAVA
                     AGGLGSASANTCFVESTAGVGEGARTGLANLMTGGLFLLALIFTPLATVVPSQAATPAL
                     LVVGFLIMAANVKEIDWSDFTIAVPAFLTIISMPFTYSITNGIGIGVLAFILLRIADKR
                     AREIPWLLNVVGLCFLVYFLLDPIEQLLGVK"
     misc_feature    18374..18387
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.08"
                     /tool="antismash"
     misc_feature    18379..18392
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.37"
                     /tool="antismash"
     misc_feature    18416..18434
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.6"
                     /tool="antismash"
     misc_feature    complement(18426..18441)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.2"
                     /tool="antismash"
     misc_feature    18459..18474
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.53"
                     /tool="antismash"
     misc_feature    18459..18475
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.85"
                     /tool="antismash"
     gene            18533..18811
                     /locus_tag="SMD11_RS13770"
                     /old_locus_tag="SMD11_2809"
     CDS             18533..18811
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004945151.1"
                     /locus_tag="SMD11_RS13770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2809"
                     /product="DUF2530 domain-containing protein"
                     /protein_id="WP_087926750.1"
                     /transl_table=11
                     /translation="MTKWTPRHEAPEPLEGNVVATITGGTVIWFVLFLVQLPFYGWFED
                     HDRLWWLWTCLAGAGLGLIGIWYVRKRDAAIRRHAAARQADAEAAAR"
     misc_feature    complement(19754..19769)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
ORIGIN
        1 agacggcggt caggggccag gcggcgagcc agacactgcg cccgccccgc ccggtccggg
       61 agtgccgggc ggcgccggtc tgctggacgg cgctcatgcg aggccgcgca gcagcggcag
      121 cagctcctcc gcggtccgct ccagcgcggc tctgtaggcc ggctcgtgga ggtcgggggt
      181 gggcaggcgc agcacgatgt ggcgggcgcc ggccgcgacg tagccgccga cccactcggc
      241 gacctgctcg ggggtgccgc cgaagatgcc ctgggtggtg cgcatggtgg gcaggtcgag
      301 gcggtagtag gcgccgaagt aggccgtcag ggtctcctcg gccttctcga cgccgcggtc
      361 cacggcgacc gagaggtaga cggcgccggt gacgtcggac tcggggcgcc cggcggcctc
      421 gcgggcctcc tggacccgca gccagccctt ctcgtagtgg gcggccgtgg tgctggtggg
      481 catccacccg tcgtagatcc gccccgtgcg ctccagcatc ttctcgccgg agtgcgccat
      541 ccacagcggg ggtccggccg gctggtcggg tacgggcagc agcgccacgt cgtccagtcg
      601 gtagtacttt ccggcgaagg agacgggctc gccctcggcg cgccacaggg cgcggcagat
      661 ctccagggtc tcgcgcgtgc ggcccacccg ctggtcgaac gggatgccgt aggccgcgaa
      721 ctcggcccgg gtggcgggtg aggagaaccc ggagccgagg cccgtgatca ggcggccacc
      781 ggagatccgg tccaggcagg cgagttcgtg ggccaggtgg acgggcgggc gcagcggcag
      841 cagcaccgcc gtgccgagct gaacccgctc cgtggtggtg gccgccgccg tcagggcgag
      901 caccgggttc atccgggagc gggccagcgg ggactcgccg gcccagatgg agtcgtaccc
      961 cagttgttcg atcttccggc tcagttcgcc gaggtgacgg ggatagtcgt tacgttcgac
     1021 gacggattcg cgtccgggga ggacgacacc gatacggagg tcggtcggcg tctggggcac
     1081 ggtgttccta tctgagaggt ccggcggggg gtgggcgggg gcccggggtc aggagaagac
     1141 ggcgtcgatc agctctcggg cctgtgccgg gttgagccgt gggtcgcaga gcgactcgta
     1201 gcgcccggac agcgcgtgct cgtcggcgac ggggccgccg agacactcgg tcacgtcggc
     1261 cgtcgcggtc tccaggtgga ggccgccggg gtgcaggccc cgctgttcga ggacgcgccg
     1321 gaaggcggcg gcctcgccga cggcgtcggc caggcggcgg gtcttgacgc cgccggcggt
     1381 ctgcacggtg ttgccgtgca gggggtcgct gagccagacg acggggtggc ccgcgcgctg
     1441 cacggcctcg acgacggggg cgacggccga cgcgggtgtc cggacgcccg tgcgcaggat
     1501 cagcgtgagc cggccgggca gccggtccgg gtcgaggacg cggcagagcc gtacgacctg
     1561 ctcggcggag gcggacgggc cgatcttgca ggcgaccggg ttggccaggg aggcgaggaa
     1621 ctcgacgtgc gcgagaccga gctggcgggt gcgttccccg atccacggga agtgggtcga
     1681 ggccaggtag ggggcgccgg tctccgggtc gcggcgcacc tgcgggctct cgtagtccat
     1741 cacgagggcc tcgtgggacg cccacggccc gtacgcgtcg gtgcgcagct cgtcgagcgc
     1801 gcgcaggacg gccgcgctcg cctcgtacgc ccggagcatc cggttggggt cgtggcggcg
     1861 ggcggccgcg tggggttccg gggagttgac gaggtggccg cggaagacgg gcaggtcgac
     1921 cccgtcgtgg gtctcggtgg ggctgctgcg cggcttggcg aactggccgc ccatccggcc
     1981 tacgcggacg acgggttgac cggtgcgcag ggccatccgg ccggccagat cggccaggag
     2041 ctccgccttg gcggcggtgt gggcggctcc gcattcgcgg atgtcctcgg cgcagtcgcc
     2101 ggtctggagc agccgggccc ggccgagggc cacctcggcg agctgccgcc gcagcacgct
     2161 cacgtcggcg gcggaggtga gcgcgggggc ctcctggagg gcgcggcgta cctcggggag
     2221 gtccgggtgg gcgccccacc gcggctgctg ctcggcgggg agcaggtccc agaccgcggg
     2281 ggccggggcc cccgcgacgg cgagcgactc gttcaccggg tccactccgg gccggggacg
     2341 agcccttcga tctccaccag caggtcgtcg cggcacacgg ccacgttcat gtacatgacc
     2401 tcggtgtcgg ggccgaaggc cgaccggcag cgctcgcgca cgaccggcag gtccgcctcg
     2461 tggcgcacgt acaccttgac caggcggagg tccttgagct cgtggccgcc gtcgaggccc
     2521 gccgcggcca ggttggggcc gctgatcagc tcggcgatgt tctccagcac cacgtcggtc
     2581 tgcgcggcga cgtcgccgcg gtggacggtc tcgtggccga ggatgctggc cgtgccggag
     2641 acgaacagcg cgccgtcgcc ctgcccggcg cccgccgggt ggagccgggt ggcgcgggcg
     2701 aagctcggcg gcttcgggcc gtactgctcg ggatagtggt aggcgggtgt ctgccgctgg
     2761 ttctccacgt gccggggtct gccctcgcgg caggcgagca gggtgaagga gatgccctcg
     2821 ccccgggtgc cgatgccggt ggcggccggc atgtggccgg tgccgtcgcc gtaggacgcg
     2881 aaggcctcgg cgcggccggc gacgaagtcc tggtagatct ccatgccttc ggcgttggga
     2941 ccgatgatgt cgccgacgaa gttccacatc cggaagatgt gggggtaacc gagctcgttg
     3001 accagcgcga aggccgcctc gtacacctcg cgcaccgtcg tccggtacac cgggagcggc
     3061 gggagggcgc cggagatgaa gaggtattcg ccgtcgtgcg cgaaggccag gctgccccgg
     3121 gtgccggatc gcggcgcggt gccggtggtc cacacctcgc ggaaggagtc gaagcccggg
     3181 gaggccatgg gaatggtcag ttccgggtac ccctgcccgg tgagggcgag accggtacgc
     3241 tcgccgaacg cgaccgtacc gaggacgtgg cgcccgggag cgggctgggg tatgccgtcg
     3301 agtgacgtga aatgggcctg taatccggcg tgttgggaca tgggagaacc cttcagtggg
     3361 ccgtcgctga ggtggggggc gagacgccag tgcactgcgg gaggaggcga gacgggtgag
     3421 ccctgcggtg ggctgtgcgt agagatgggg cttcggccgc gcgggtcggt ccggcgcgtc
     3481 gacaaagcgt gttttgggca cagttgggcg cggcgcagca cgctgcgacc ggctccggct
     3541 cactcccccc gtgatcgtct gccggtacga ccgcacccgc gcatgtgtgt gtacggtcaa
     3601 cttttattcg gcggcaggca aagtgagttg agccacaaga ggagcctggc tcctcttacg
     3661 caccttccac cccacccgcc cgaacggcgt cctccgcaag gagattcaac ctctccaccg
     3721 gcccggccgg ccgcagcgtg cagctccgcc acgcgaaccc gttgggatgc cggacgagca
     3781 ccatgccact gggctccacc tcgacgaccc tgccggaacc accggcgacg gtgtcgacga
     3841 cgatcgcccc gatcggggcg cgggcgaggg gcagttggac ggattcgggg cagcggcagg
     3901 agtcggagag ggcgggtgcg cgggggacga ggttgaagcc gtgggcgccg gcggcgatgt
     3961 ggaggggggc ggggctgggg tgggggtggt gcgggggttc gcgacggggt tgcgtcgtgc
     4021 gaaacgcgct ctcgcccagg cgatgaggcc gacgataggg tttttcacgt catcagctcc
     4081 ttggtcggac aggtgaccac accccccggg ccggtcggac ggctgcgggg ggcttttggc
     4141 gagcgccaca atagagaggg tgtgatgcag atgtctatag gcgtatgccg aggttagcta
     4201 ctatgttcga ctaggtgtct atacctacag tcgcccccgt gatggaattc gaccccacgc
     4261 tcccgaagtg gacgcagatc gcgcaggtca tccggcagcg catcgcctcg ggcgagtacg
     4321 cgccgaatca cttggtctcc gagacccagt tggagcagga gttcgacgtc gcgcgcgtca
     4381 cggttcgcaa agtcacccgc gcactgcgcg aagagggcct gatcgtcact acacacggca
     4441 tggggtcgtt cgtcaccgaa caggccgccg ggatcatcaa ggcatccaag gacccctcag
     4501 cggggtgacc gcgcgcggag ccggtcggcc cattcgtgga gcgggccggc gagttcgtgg
     4561 ttgtcaccac gactgagggt ctggaggagc tcggccgcga tgacggcctg cccggtccag
     4621 gtctgcgggg cgtccaggtc ggggaaggcg gcgcggaccc gggccgctgt ggccggtcgg
     4681 agcaggctgt aggcgtagag ggtggcctgg tcgtagccgt agggcgcccg gccccaccct
     4741 tcccagtcga ggatccgcag cccgggtgcg gtgaggttgg cccagtgcag gtcgccgtgg
     4801 gcggtggtcc aggtgatggc atcgggggcg gggacgccga ggaactccgg cagggcgcgg
     4861 tggatgtact cctggcggac cgcgatccgg tcggtggtga cgtcggcgac ggtgcccagg
     4921 gcactgccga gagccgtcca ccacgcggcg gggaggccgt cggggacgcg caggaccgga
     4981 tcgtcggaga tgacgtcctg gtccaggtgc tcgctcagct cggcgcggtg gacggtcccg
     5041 tcctcggcct cgtcgtgcac cgccagcagc gcgggcctgt gtccgtgcag gtcgccgaac
     5101 gcctgctggg cgtccgtcgc cccttcccac gtcttccctg acgccttgcc ggccggggcg
     5161 gagaccagcc gcagccacac ccgccggccg tcgccggtga caccgggccg ccccagggtc
     5221 cgtcccgccc agccccagcg ctcctcacca ccgccgagag tgacggcgag ggcgcgggcg
     5281 gcgtggtcgt gacgggtgcg catccgctgc tcttcggccg cgtccggtgg gggcgagtac
     5341 acgttgttct cccgtgaatc gtcggacttc cagggtgtgt ccggcagatc cttccccagc
     5401 cccgccccgt cccgccgcat ccggtgtgcg gcgccgtcgc gccgcaggtc tccgccccgt
     5461 ccttcggacg ccgagcggcc gggaattccg tcccgggtcg ttcagcccgc cgccgtgaac
     5521 accagcgacg cgttgtgccc gccgaacccg aacgcgttgg ccagggctgc cggtacgcgc
     5581 ccgtggcgag gggatccggc gaccacgtcc agggggacct ccgggtcgag gtcgacgagg
     5641 ttgcgtacgg gcgggaccgc gccgtcgcgt acggcgagga tcgccgcgat cgcgccgatc
     5701 gcgcccgccg cgccgaagag gtgaccggtc atcgacttgg tggccgtcac cgacgggtgg
     5761 gtgccgatcg cctcggcgac cgagcgggcc tcgacgaggt cgcccagctg tgtggacgtg
     5821 gcgtgggcgt ggacgtgcgc gatgtccgcc ggggtcagtc cggcggccga cagggccagg
     5881 cgcatcgcgc gtacctggcc ctccgggtgg gcggccgtga tgtggtgggc gtccgaggtc
     5941 acgccggcgc cggcgaggac cgcgtgcggg cgggcgccgc gggcggcggc gaacccggcg
     6001 cgttccagga cgaccacgcc cgcgccctcg ccgatgacga ggccgtcgcg gccggtgtcg
     6061 aacgggcgtg aggcgcccgc cgggtcgtcg ttgcgggtgg agtgggcctt ggcctgggcg
     6121 aacccggcga tgggcagcgg gtgcacgcag gcctccgtgc cgccggcgac cacgacgtcg
     6181 gcccggccga ggcgtatcag gtccaggccc atggcgatcg cctcggcgcc ggaggcgcag
     6241 gcgctcaccg gggtgtgggc gccgccccgg gccccgagtt ccatgctgac ccaggcggcc
     6301 gggccgttgg ccatcagcat cggcacggtg tgcggggaga ccttccgtac gcccgacgcc
     6361 tccaggacgt cgtcctggcc gagcagcgtc aggacgccgc cggtgcccgt gccgatgacc
     6421 acggcgagcc gctccggctc cacctcgggc cgcccggcgt cggcccacgc ctcgcgggcg
     6481 gcgagcagcg cgatctgctc gcaccggtcc atgcgccggg cctgcacccg gtcgagcagc
     6541 ccggccggct cctggcgcag gcggcccgcg atgcgtacgg gcagttccgc cgcccagtcg
     6601 tcctcgatgg cgcggatccc gctctcgccg cgcagcatcg cctcccaggt ggacgcgatg
     6661 tcgccgccga ggggggtggt ggcgccgaga ccggtgacgg cggcgctttc gttggtgacg
     6721 gtcatgaggg tcccccttgt ggtgatggca cagttcaccc gtggtggcgg gtggtgcggg
     6781 tttctgcctt cgggtccact gtgccaaggg gagagcgggg atagcggcta gatgatcaac
     6841 ggagtcgggg ggtgagagat tgttgggttc cgctatggac cggacaggtc gggtgggtcg
     6901 cgaccggcgt ccgggagtgg gcgggcgcgt acggcggggc ggcaggatgg ggcgtccgcc
     6961 gaccctcggc ggcgtccctg ggcggccgcc tgacccgggc gccggccctc ggcccctcac
     7021 ttcctccgga acagcctccg cagcgacacc accagcaacg tcgccaccgc gaacgtcccc
     7081 gcccccaccg cgagattgcg gttgcggtcc ccctcgtccg tgccgtcacc ggacttcccg
     7141 tccgacgacg cgccaccgcc gttcctggcg tcgtccggcg ccttcgccac cgagtccggc
     7201 agtaggtcgc cgtccagccc gaccggctgc accgaactcc gcctgccctc cgagccgtac
     7261 atcagcgtcc gcccgtcggg cgcgaaggtg accgactccc cctgccgctg gagcggtacg
     7321 cccgggcggc cgacctcctc tgggcggccg tcgcgccagc ggtactcgcg cgcgtcgaag
     7381 tagctgcgga cgacgagccg ggtgccgtcc ggcgagaacg cgccgtccgt ggcccagacg
     7441 tcgatgtccg cgacgcgccg gaaggtgttc acgccggacg cggacagctt ctccggaccg
     7501 gcgtagaggg cgctcttccc ggactgcttc ttgctgacga tgtacacccg gcccgtcctg
     7561 ggatgcacca tcagcgactc ggcgtcgcgc gggccgtcgt cgtagcgcac ggtgtggcgg
     7621 acgggcgtga cggtggtgtc ggccagcttc ttcggctcgg ggaagcgata gatccacact
     7681 tcctgccacc ggccgccgta gttgtcccct atgtcaccga cgtagatgtt cccgtccggg
     7741 ccgatcgaga tgccctccac gtcgcggggg tcgatgtcgg cgagggtgac ggtcgcgacc
     7801 gtacggccgg tgcggctgtc cacggcgtag acgtacgggc cgtcgtcgct gtcgttgtgc
     7861 gtccagtaca cgcccgggtg cgcgcggctg gcggccaggc cgctggactc ccttatccgg
     7921 gggtccgtga tggtgaacga cttgggggtc tcggcggcgg cgccgtcggc cgcccgcgcg
     7981 acggcggcac ccggcagggc ggcgaaggcg aaggcgccga acgcgctcag cgcggcgagt
     8041 ccgaggacgg cccggcgggc ggaagggccg gaaggaccgc cggcgcgacg gcgcggggcg
     8101 ggccgacggc cggttccgca tacggttccg ctcacggctc cggctacggc accgcggccg
     8161 gttccgtctc cggtggcagg caagggctgg cgcatggtcc caagcctgcc atcacccggg
     8221 gccccggccg cccggacccg gaactccggg aaatatcgct cgaacaagct gtccctcaca
     8281 cgtatcgtga ccgcgcgcgt cacacgggac gcgcggcacg ggcgaaaggc tgggatcggt
     8341 ggagtacaac gggtgggccg acgaggggtt cggcgccgtc gcggacgcgt tcggccggaa
     8401 cttcaccgac cacggggaca ccggcgccgc cgtcactgtg ttcgtggacg gccgcaaggt
     8461 cgtcgacctg tggggcggca ccgccgacga gcggaccggc cggccctggg aacgggacac
     8521 ggccgtcccc gtcatgtccg cggccaaggg cgtcgtcgcc gtctgcgccc acctcctcgc
     8581 gcaggagggc cgcctggatc tggacgcccc gatcgccgac cactggccgg agttcgcgcg
     8641 gcacggcaag gagcggatca ccccgcgcat ggtcctcgcc caccgcgcgg gcctgcccgt
     8701 catcgaccgg ccgctgacct tcgaggagat cctcgcctgg acgccggtgg tacgcgccct
     8761 ggaggagcag gccccgtact gggagcccgg caccgcgcac gagtaccacg ggcacaccat
     8821 gggctggctg atcggcgagg tgatccgccg gatcacgggc cgcacgcccg gcgcctactt
     8881 ccgtacggcc gtcgccgacg agctgggcct gaccacctgg atcggcgtcc cggaagccga
     8941 actccccggc ctggcccgcc tctccgaggc gcccggtacg tacccggagc tccccgccga
     9001 gtcgctcttc gcgcggatcc tcacgatgga cggggcgctc ccgttccccg gcaccgacca
     9061 cccgcgcggc cggaactcgc ccgcggtcct cgccgccgag atccccggca cgggcgccgt
     9121 ctcctccgcc cgcggcctgg ccacgctcta cgcggcggcc gcgaccggcg tcgacggcgc
     9181 gccccggctg ctcacccggg acaccctcac cgacgccctg cgggtacgga ccgacggacc
     9241 ctcctggtcg ggcttcccgg acgggggcgt gcactggggc agcggcttca acgtcgcgtc
     9301 ggagagcgtg ccgctgctgg gggcgcgcag cttcagcaac gagggggcgg gtgggcattt
     9361 cgcgctgggg gacgacgagt tgggggtcgg gttcgcgtat gtgacgaacc ggatggtggg
     9421 gggtgaggat cctcgggggc cgttgctggt gggggctgtc cgggggtgtg tggcggggtg
     9481 agggtgaccc gtggtggggc gggcgggtgc gggcgggtgc gggcgggtgc cgctgcgcgg
     9541 ggcctttccc caccccgccc cttcccgata ccggggctcc gccccggacc ccggtcctca
     9601 aacgccggac gggctgagcc gttgcccgga accgggcgaa aatcagcccg gctgggggca
     9661 cctcccagcg gtagctgggg gagtttgagg ccaccgcgcg tcagcgcgga aaagggggtc
     9721 tgggggcgaa gcccccggtt tcgggaaggg gcggggctgg ggaacaaaac ccgccactcc
     9781 ttcgggtggc cggatccccc accccgcgta acccaccccc accacggaca gcctcgaccc
     9841 aacgcgcagc cgcacacgca cacgcacacg cgaagggacc cgcccatgga gcctcaggag
     9901 agctacgagc cccccgcact cgaagagctc ggtgacttct cggagctgac ccggggccgg
     9961 ccggcggccg aagcggcgga agacgtctga gaggcgcccc atgagtgtgc tcaccctgca
    10021 ccccgacgtg tccgccgcgg acaccgagga cggaatggtg ctgctcgacg aggtcggcgg
    10081 gcgctactgg cagctcaacg gcaccggggc gaccgtgctg cgcgccctgc tcgacggcgc
    10141 gaccccgggg gaggtggcgc gctcgctcgc cgagcgctac cccggcctga cgacggagcg
    10201 gacgaacagc gacgtggcgg cgctcatcat ctcgctgtcc gaggcccgcc tggtggtgac
    10261 ggcgtgagcc ggccgatggt cctggagccc cgggagcccg tgccgctccg ccgccgcccg
    10321 gcggccctgc tggccgtcgg cgccgcccgg ctgctcgtcc tgctgccgcc ccgccgcatc
    10381 cgccgcgccc tgacgctggc ccggcgcggc gccgcccccg ccaccgcgga ggaggccctg
    10441 gccgcccggc gggcggtcgt cgccctgagc gcccggtgcg cgggcgaggg ctgtctccag
    10501 cgctccatgg cgacggcact cctgtgccgg atgcgcgggg tctggcccga ctggtgcaca
    10561 ggggtgcgca cgagcccgtt ccgcgcccac gcgtgggtgg aggtggcggg tctgccgatc
    10621 ggtgagtcgc actcccccgg ctactaccac cggctcatgg tcgtaccggg cggaggaccg
    10681 ggcggaaggc cgggcacagg gccgggccgg agggagccgc gagcggccgt gacagcgcct
    10741 ggagcggccg ccgtcaccgg tccagcgtga acgagacgtc gtcgatgaac cacgacgtcg
    10801 cggcgatgcc gacgaagacc cgcccgctgc cgttcccctc ctgcctggcc ggggagaaga
    10861 gattacggac gaccgtgccc gtgcccgcct gccgcgcctc ggtgcggccg gggtcgaggc
    10921 gggtgaaggt ccggtccgcc ttgaggtcgg agacctcgtt cgtgttgtag acgacgtggt
    10981 cgtccgtcgt ggtcaccacg tccggcccgc tgccgcccgt ggcccggccc ttcatggtga
    11041 gggtcgcgga ttcgatccgc gagcggctgg gcgcgtcgca ggtcagcctg cccaccccgg
    11101 tcgcctcacc gttgggcttg acgtccatgc ggagggagcc gtggcagcgc aggacgacgg
    11161 cggcgtcctt cccttccccg gcgctcttcc cgcttccgcc cgccgccgcc gcgcccggac
    11221 cggccggggc gagcatgagc gcgaggacgc ccgcggcggc cgcaccggtg agcacccggc
    11281 gggtggtggc gcggcgcgcg gtggctgtcg tcgataactt cgagatcatg ggtgaatcct
    11341 tctccttcgg agggttcccg gcgggcggga gggacacacc gtccgctcag gagcgtgctc
    11401 ccgtcgatcc cccgtagaaa cccggacggg atcactcgta cgggtgaacg catccggagg
    11461 gcccaaaccc gattcccccg acgggaccgg ggccccgaac ggccacttcc accctgccgg
    11521 acgcctcggg cccacgctgc ccctcgcgcc cgcccgggtc acgctcgtac caccgcccct
    11581 gcgagacacc cggcaggccg gaaaagagga caagaacgag gacaagaaca agaacgagga
    11641 cgaggacgag gaagggctcg gacaccatgt tcacgaacac caaggcgttc agcggcttcg
    11701 ccgtggacga catcgagcgc gccaaggact tctaccaccg gacgctcggc ctccgcgtca
    11761 ccgaggagtt cgggctcctg acgctgcaca tcaccggcgg cacggagatc ctcgtctacc
    11821 ccaaacccga ccacaccccc gcgagcttca ccgtgctcaa cttccccgtg gacgacatcg
    11881 accgtgccgt ggacgagctg acctcgcgcg gcgtccgctt cgagcggtac gagcagttcg
    11941 aacaggacga gaagggcgtc ttccggcagg aagggccgcc catcgcctgg ttcacggacc
    12001 ccgccgggaa cgtcctgtcc gtcctccagg cggccgggcc gcaccccgcc cgtaaggcct
    12061 atagcctgac cgtatgcgga tcatgttcgt cggcgactcg atgaccatcg gtagcgccgg
    12121 tgactacaca tggcggtacc gcatgtggca gcacctcaac gcctcctacg gcggccccta
    12181 cagaatcgtc gggccgcgca ccgagctgta cgacccctcc gtcgacgcgc ccggctcact
    12241 cgcctacggg gacgccgcct tcccggcccg cgcccaggcg cacctggccg gctggggcga
    12301 gggctggctg cacatggcgc cgctgatcgg cgacgccgtc cgcgcgggca aggccgacac
    12361 cctgctgatc tccctcggcc tgatcgacct cggcttctac accgacgccg agcagaccgc
    12421 cgagaacgtc caccgcttcc tcgccgccgc ccgcgaggcc aacccgcgcg tccgggccgt
    12481 actgctgccg gtgatccaca acgtgcgggc gctcaacgac ccgcccttcg ccgcccagtg
    12541 cgagcgcttc aacgaactgc tgggcaaggc cgtcgccgag ctcgactccc cggcctcgcc
    12601 gctgctgctc gcctccccgc ccgagggctg ggacatcgac cgcgacacct acgacggcac
    12661 ccaccccaac gccgagggcg agcaccgcct ggccgccgcc ttcgccgacg cgatgcacca
    12721 ggcgtgggac gtcgccggcc cgtacgaacc cgcgcgcggc tgaccctccg ccccctcccc
    12781 cgggcacccg gcgcacctcc actcgccggc gcgcgcccca cgcgcccctc gacgcgccgt
    12841 cgcgggagac cacccttgcc tcaagcgcac tccaaggcgt tggctaggcg gctatggagt
    12901 acacgcagct cggacgcaca ggtctcaagg tcagccggat cgtgctggga acgatgaact
    12961 tcgggcctcg gacggacgag gccgacagcc acgccatcat ggacgccgcg ctcgacgcgg
    13021 gcgtcaactt cttcgacacc gcgaacgtct acggctgggg cgagaacaag ggccgcaccg
    13081 aggagatcat cggcagctgg ctcgcgcgcg gcggcgggcg gcgcgagaag gtcgtcctgg
    13141 ccaccaaggt cttcgggaac atgggcccgg acggcgcgga ctggccgaac cacgaccggc
    13201 tgtccgccgt gaacatccgg cgcgccgtcg acgccagcct ccagcgcctg cgcaccgacc
    13261 acatcgacct ctaccagttc caccacgtcg accggaccac gccgtgggac gagatctggc
    13321 aggcgatcga cgtcctcgtc cagcagggca agatcgtcta cgcgggctcc tccaaccacg
    13381 ccggctggca catcgcgcag gccaacgagg cggcgcggcg gcgcggctcg tacgggctgg
    13441 tcagcgagca gtgcctgtac aacctcgccg agcggcgggc cgagatggag gtcgtcccgg
    13501 ccgccgaggc gtacgggctc ggggtcatcc cctggtcgcc gctccagggc gggctgctcg
    13561 gcggcgtcat ccgcaaggag cgggagggcg gcggcgcggc cggccggtcg tccgaggcgc
    13621 tcgcgaacac caaggtgcgt gagcaggtcc aggcgtacga ggacctgctc gacaagcacg
    13681 gtctggagcc cggtgaggtg gcgctggcct ggctgctcac ccggcccggc gtcaccggcc
    13741 cgatcgtcgg cccacgcacc ggcgagcagc tgtcctcggc gctgcgcgcc gtcgagctga
    13801 agctgccgga ggaactgctg accgaactgg acgggatctt ccccggtccc gggccctcgc
    13861 cggaggcctt cgcctggtag ccgggcggcc gcgcgggcgg tccgggccgg gcggtacgcc
    13921 gggcctcgcc cggtggcggc ggccgtccgc gcgtccggtg gcgcgcggcg gccgtccgcg
    13981 cgtcacttca cggccgacac cacggcgacg acgacgagca tcacggcgag cacaccggtc
    14041 atgatccggt tcctggtctt ggggtccacc ccttgagcgt aaccgccggg cccccgggct
    14101 cagcgaccca gcccccagga ggccaccgtc gtatagcggg ggcgctcgcc gggcacgccg
    14161 gaggccggga gggtgctgcg gacgagcgcg agccggtcga cggtccaggg cgtgcccgcg
    14221 aagtccgcga ggtgctcctc gtacgggccc aggcgcaccg ggccggcggc gcgggcgagg
    14281 gtgaggtggg cgcggaaggg gtgcttcccg tccacctcga caccggcccg gcgggcgccg
    14341 gcggcggtgg agcgggcgag gtcgcgcagg gtggtcagct cgccctcggc gccgacccag
    14401 aggatcttgt cgtcgaaccg gccggcggcg gcgagccgca gcgggtgcgg cgggtgccgg
    14461 tgcgcggcgc gcgccaggcg ctcgccgagc ccggggagca gggcctcgtc gacctcgctg
    14521 aggaaggcga gggtgaagtg ccaggtcgcg ggctcggtcc agcggaggtg ggcggcgccg
    14581 gggaggccgt ggaggggggc cagggcggct tccagctcgg cgacggcctg cgggggcggg
    14641 atgactgcgg cgaagagtcg catgggttca gtgtggcggg gcccgcgggt acgggcggag
    14701 gtttctcccc tacccgcccc ttcccgatgc cctcagacgc cgggcgggcc gaaaatcagc
    14761 ccgcccggtc gtccggggcg gagcccccgg ttcatgccgc cgtcgtcacc gccgccggct
    14821 cccgcaacgg ctgccgtggc acgaaggcca catgcgtatg gccgcgccgc aggtctatct
    14881 tcagacgcag gccgcccacc cgcgccaggg ccatcccgac gcccgtcgcg gccagcagcg
    14941 agacgacgcc accggcgagg aagccgacgc gcgcgccgta gacgtcggtg acgtatccga
    15001 cgagcggggc ccctatgggc gtgccgccca tgaagaccat catgaacagg ctcatgaccc
    15061 gcccccgcat cgcgggatcc gtggccatct ggaggctgga gttggcggtc acgttgatcg
    15121 tcaggccgca catcccgatc ggtgccagca gcgccgcgaa gacccagaag ctgggcgcca
    15181 gcgcggcggt gatctccagg acgccgaaca gcagcgcggc tccgaccagc agccgcagcc
    15241 gggagttgcc gcgccgggcg gcgagcaggg cgccgaccag cgagccggcc gccatcaggg
    15301 tgttgagcag gccgtacgta ccggcgccgg cgtggaagac gtcgttgacg taggccgtga
    15361 gccagatcgg gaagttgaac ccgaaggtgc cgatgaagcc gacgaggacg atgggccaga
    15421 ccaggtccgg gcgccccgcg acatagcgga ggccctcgcg cagctggccc ttgccgcggg
    15481 gcgcgcgctc caccttgtgg agctcggagg tccgcatgag cagcaggccg acgacgggcg
    15541 cgacgaagga caggccgttg agcaggaagg cccagccgct gccgacggcg gtgatgagga
    15601 caccggcgac ggcggggccg acgagccggg cggactggaa gttggcggag ttcaggctga
    15661 cggcgttgcg caggtcgtcc gggccgacca tctcgacgac gaacgcctgg cgggcggggt
    15721 tgtcgacgac cgtgacgagg ccgaggacga gggcggtgac gtagacgtgc cagacctcga
    15781 catggccgga gagggtgagc accgcgagcg ccaggccggt gaatcccatg gcgacctggg
    15841 tgatgagcag cagcagacgc ttggggtagc ggtcggcgat gacgccgccg tagagcccga
    15901 gcagcagcat gggaaggaac tggagggctg tggtgatgcc cacggcggcg gaggagccgg
    15961 tgagaccgag gaccagccag tcctgggcga tgcgctgcat ccacgtaccg gtgttggaga
    16021 ccacctggcc ggtggcgaag agccggtagt tccggatccg gagtgagctg aaagtgccgc
    16081 ccttgttctt ggtgaggctt tcggtgaggg cggtgcgggt gtcgtcgtcg tgggctttcg
    16141 gtgcgggtgc ggagtctgct ccgggtcccg tactcaaagt ggattcgcct cctccttgtg
    16201 tgggtgttac aggtgcgcga gcttctccag cacgggcgcg gcggcgcgga gcgtcgccca
    16261 ctcgtcctcg tcgagctgcc cgaccagttc ggtgagccag acgtttcgct tgcgccggct
    16321 ctcctcgagc atggcctcgg cccgctcggt ctgggtgacc accttctggc ggcggtcctc
    16381 cgggtgcggc tccagccgga ccaggccctt ggcctcgagc agggcgacga tgcgggtcat
    16441 cgacgggggc tgcacgtgct ccttgcgggc gagctcaccg ggggtggcgg tgccgcagcg
    16501 cgcgagggtg cccagcaccg acatctccgt cgggctgagc gactcgtcga cccgctggtg
    16561 cttgagccga cgcgacagac gcatgacacc ggagcgcagg gagtccactg cggcggtgtc
    16621 gacttggggg tccgggtccg acatgttcat taggttaact cattacctga tctaaataaa
    16681 gcgagacaaa agaaggcggc cgggccccgt gcccggccgc cttcccgagg cgtccagaag
    16741 atcatctact gtacgcggac gctcggcttc cgcctcgccg cgtcgtcccg gcgccgccgc
    16801 cgtcgctact tcacgccgag cagctgctcg atcgggtcca gcaggaagta gacgaggaag
    16861 cagagcccga ccacgttgag cagccagggg atctcccgcg cccgcttgtc cgcgatccgc
    16921 agcaggatga aggcgaggac gccgatgccg atgccgttgg tgatcgagta ggtgaacggc
    16981 atggagatga tcgtcaggaa cgcgggcacc gcgatcgtga agtcgctcca gtcgatctcc
    17041 ttgacgttgg ccgccatgat caggaagccg acgaccagca gcgcgggggt ggccgcctgc
    17101 gaggggacga ccgtggccag cggggtgaag atcagggcca gcaggaagag gccgccggtc
    17161 atcaggttgg ccaggcccgt gcgggcgccc tcgccgacac cggccgtgga ctcgacgaag
    17221 caggtgttgg cggaggcgga gccgaggccg ccggccgcga cggcgacgcc gtcgaccatc
    17281 aggatcttgc ccatgttggg cagctggccg ttcttgtcgg tcagcccggc ctcctcgccg
    17341 acgccgatga tcgtgcccat cgcgtcgaag aagccggaga gcagcacggt gaagacgaag
    17401 aggcagccgg tcagcaggcc gacctcgtgg aagccgccga acaggctgat gtcaccgacg
    17461 aggccgaagt cgggcgcgcc gacgacgctg tccggcatcc gcgggacgct cagcccccag
    17521 ttggcgtcgg ggatctcgat cagggtgttg atgacgaccg cgacgaaggt catcacgacg
    17581 atgccgatga ggatggcgcc ggaggtcttc cgcaccacca ggatgaaggt cagcgcgagg
    17641 ccgatcgcga agatcagcac cggccagccg tgcagctgcc cgccctgacc gaggccgagc
    17701 ggcacggtgg tgtgcgcggc gtcggggtta cgggtgacga agccggagtc caccaggccg
    17761 atcagcgaga tgaacaggcc gatgccgatg gcgatcgcgc gccgcagccc gccggggatg
    17821 gcgtccatga cgcgctgccg cagaccggag gcgaccagca gcatcagcac caggccggcc
    17881 agcaccacca tgcccatcgc gtccggccag ctcatcttgg gggcgagctg gagcgagacg
    17941 acggcgttga tgccgaggcc cgcggcgcag gcgatcggca cattgccgat cgcgcccatc
    18001 aggacggtgg tgagaccggc catcagggcg gtggccgtca ccagctgggc gttgtcgagc
    18061 tggtgcccga acttgtcctg accggccccg aggatgatcg ggttcagcac gatgatgtac
    18121 gccatcgcaa agaacgtggc caggccgccg cgcagctcgc gggtgatgct ggagccccgc
    18181 tcggtgatcc ggaagtaccg gtcgaggggg ttgccgggcg gcggcacggg ggccggctgc
    18241 tgggcgtcga ccggggaggt ggccgaggag ggcatacgag acctcagtcg tacgggcctg
    18301 gggaaggcgc gggaaagacg ggaaaggctg gggtggtgcg agggaatcct gggacgaaac
    18361 aaaaaggatc ttgattggat gatcaaacaa aaccaaccag tcagatcccg ttcgattcag
    18421 tatgaataaa caaggcgtga attgctatct ccgcgcgtag acccctatgg ggcaagggat
    18481 ccgttccccg ccccgccggg gcttcgcgga agccacggac tacgcttgcg ccatgacgaa
    18541 gtggacaccc aggcacgagg cgccggagcc cctggagggc aatgtcgtcg ccaccatcac
    18601 cggcggcacc gtcatctggt tcgtcctctt cctggtgcag ctgcccttct acggctggtt
    18661 cgaggaccac gaccgcctgt ggtggctgtg gacctgcctg gccggcgccg gcctcggcct
    18721 gatcggcatc tggtacgtcc gcaagcgcga cgcggccatc cgccggcacg cggccgcgcg
    18781 gcaggcggac gcggaagccg ccgcgcgctg accgggcgcc gccccgggcc cgcctcgtcc
    18841 gccgacggcc gacggcgggc acccggcccg aaaggccggt tcggcgggta gatccgccga
    18901 accgcccgta ccgtcggact catgagcgat ccggcgcaga ccgcgaccga tgaatccgta
    18961 ccgccggccc cgcacaccgg cctgaccgcg cccgaggtcg ccgagcgggt ggcgcggggc
    19021 gaggtcaacg acgtccccgt gcgctcctcg cgctccacca cggagatcgt ccgggcgaac
    19081 gtcttcaccc gcttcaacgc catcatcggc gtcctcttcc tgatcatcct ggtcgtcggc
    19141 ccgatccagg acggcctctt cggcttcgtg atcgtcgcca acaccgcgat cggcatcatc
    19201 caggaactgc gggccaagaa gaccctcgac tccctcgccg tcatcggcga ggcgaaaccc
    19261 accgtgcgcc gcgacggcac ccccgtcgcc gtcgccaccg ccgagatcgt cctcggcgac
    19321 ctcatcgagc tcggccccgg cgacaagtgc gtcgtcgacg gcgaggtcct ggaggccgac
    19381 ggcctggaga tcgacgagtc gctgctcacc ggcgaggccg accccgtgct caagcggccc
    19441 ggcgacaagg tgatgtccgg ctccttcgtc gtcgccggcg gcggcgcctt caccgccacc
    19501 aaggtcggcc gcgaggcgta cgccgcccag ctcgccgagg aggcctcccg cttcaccctc
    19561 gtccactccg agctgcgcac cggcatcagc cagatcctca agtacgtgac gtggatgatg
    19621 atccccaccg ccgtcggcct gatcatcagc cagctggtcg tggagcggga cgactggcgg
    19681 gaggccgtcc ggcggatggt cgccgggatc gtgccgatgg tccccgaggg cctggtgctg
    19741 ctgacctccg tggccttcgc catcggcgtc atccgcctcg gccgcaaaca gtgcctggtc
    19801 caggagctgc ccgcgatcga gggcctggcc cgcgtcgaca ccgtctgcct cgacaagacc
    19861 ggcaccctca ccgagggcgg catggacgtc accgagctgc ggatcctgcc ggacaccggc
    19921 gccgacgagg cgtacgtacg ccaggtgctc ggcgccctcg gcgactccga cccgcgcccc
    19981 aacgccagcc tccaggccat catcgacgcc taccccgacg gctccggctg gcgctgcacc
    20041 gagtccctgc ccttctcctc cgcccgcaag tacagcggcg ccgccctcaa cagccccgac
    20101 gcggagagca gcaactggct gctcggcgcg cccgacgtgc tgctgccggc cggcgacggc
    20161 gccctgaccg ccgtcgagga gctcaacgcc caggggatgc gcgtcctgct cctcgcccgc
    20221 gccgagcgcg agctcgacga cccgcgcgtc accgaggccg tccggcc
//
