LOCUS       NZ_CP021744            10381 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces albireticuli strain MDJK11 chromosome, complete genome.
ACCESSION   NZ_CP021744
VERSION     NZ_CP021744.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces albireticuli
  ORGANISM  Streptomyces albireticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Streptomyces albireticuli Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8144417)
  AUTHORS   Wang,Y., Du,B., Ding,Y., Liu,H., Hou,Q., Liu,K., Yao,L. and Wang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2017) Department of Mcrobiology, Shandong
            Agricultural University, No.61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 2.3
            Expected Final Version            :: yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 07:12:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,975
            CDSs (total)                      :: 6,876
            Genes (coding)                    :: 6,711
            CDSs (with protein)               :: 6,711
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 165
            CDSs (without protein)            :: 165
            Pseudo Genes (ambiguous residues) :: 0 of 165
            Pseudo Genes (frameshifted)       :: 74 of 165
            Pseudo Genes (incomplete)         :: 97 of 165
            Pseudo Genes (internal stop)      :: 5 of 165
            Pseudo Genes (multiple problems)  :: 9 of 165
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:17:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2542301
            Orig. end                         :: 2552682
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021744.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10381
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="19"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10381
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10381
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5381](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5381)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            1090..1965
                     /locus_tag="SMD11_RS10525"
                     /old_locus_tag="SMD11_2152"
     CDS             1090..1965
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131385.1"
                     /locus_tag="SMD11_RS10525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2152"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_087926201.1"
                     /transl_table=11
                     /translation="MSSNSPVSVLGLGAMGKALATAFLTGGHPTTVWNRTPGKADPLVA
                     LGAARAADVTAAVTASELVVVCLLDDASVHETLDPVAAELAGRTLVNLTNGTPAQARAT
                     AGWAAAHGIAYVDGGIMAVPPGIGTDQAFVLYSGAEDAFAAHRPALERLGAARFVGADA
                     GLAALYDIALLSGMYGMFAGVFHALALVGTEQVPAAEFAPLLTGWIGAMATAIPHMAEQ
                     AESGDYTDGVVSNAAMQAAAFGNLLRTAEDQGVSGELIAPLRPLLDRLVAEGGGAGDVT
                     GIVGLLTKPA"
     gene            complement(2196..2822)
                     /locus_tag="SMD11_RS10530"
                     /old_locus_tag="SMD11_2153"
     CDS             complement(2196..2822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841191.1"
                     /locus_tag="SMD11_RS10530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2153"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_087926202.1"
                     /transl_table=11
                     /translation="MTTSVKLTVLGATGMAGSRIVAEALTRGHAVTAVARSHDEQAPAR
                     DGLRRVSADVAGAVPAPELLDGADVVVSALPARTVLPLLPELVTAAGGTRLVFVGGAGS
                     LRLPNGERVIDQPGFRDEWKPEASAHVELLDALRALPEGVDWTFLSPSALFLPGERTGT
                     FRLGGDDLLTDTEGASRISGEDYAVALLDEVETPAHRRARFTVGY"
     gene            complement(2885..3394)
                     /locus_tag="SMD11_RS10535"
                     /old_locus_tag="SMD11_2154"
     CDS             complement(2885..3394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003563.1"
                     /locus_tag="SMD11_RS10535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2154"
                     /product="hypothetical protein"
                     /protein_id="WP_087926203.1"
                     /transl_table=11
                     /translation="MRKRALPALGLTVAAAGIAGAALALSPATAGAASPAYTGPRTVTI
                     EAVERGTSINMVDVAPADSALGDQLIGTGDLVGTDGRTLGTSSFQGISTDAEPRTSEML
                     TFVYDLGDGNKITTSGTAKLNAKGPVFDEQFAITGGTGKYKNARGQVRVLQETVEQAKV
                     TFDIQL"
     gene            3524..3949
                     /locus_tag="SMD11_RS10540"
                     /old_locus_tag="SMD11_2155"
     CDS             3524..3949
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357064.1"
                     /locus_tag="SMD11_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2155"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_234365992.1"
                     /transl_table=11
                     /translation="MLNDDDVTLYGLFVEAFSRLKPLVHEDLGVPDTWFEVLLRLGRTP
                     GHALRMSDLATAVAFSSGGFTRLADRMEEAELIRREPDPDDRRAALAVLTPAGEKALDR
                     ALSRHLAHLRTHVSGRLSEEDRRAFERVLRLLRDGDA"
     gene            complement(4101..4958)
                     /locus_tag="SMD11_RS10545"
                     /old_locus_tag="SMD11_2156"
     CDS             complement(4101..4958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267950.1"
                     /locus_tag="SMD11_RS10545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2156"
                     /product="tyrosinase family protein"
                     /protein_id="WP_087926205.1"
                     /transl_table=11
                     /translation="MAVRKNQAKLSKAERRDFVEALLELKRRGGYDKYVEIHDRFVMSD
                     LDDQERTGHVSPSFLPWHRQFLLDFERDLQSVNPAVTLPYWDFTVNRSLSDPIFAPDFL
                     GGTGRERDAQVMDGPFAYSGGRWPIYFKADERPFLMREIGKNKGTPQLPTAATVEAALA
                     APYYDEAPWNSTSKAGFRNLVEGWANGNTGPHNAVHRWIGGHMNTGMSPNDPVFWLLHC
                     FIDKLWADWQKRHPKVPAYLPVEPVKDIVALNQPMKPWIEQGKRVVPADLIDHKKFYKY
                     DTDV"
     misc_feature    complement(4950..4964)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.55"
                     /tool="antismash"
     misc_feature    complement(4952..4968)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.55"
                     /tool="antismash"
     misc_feature    complement(4958..4967)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.02"
                     /tool="antismash"
     misc_feature    4960..4974
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.79"
                     /tool="antismash"
     gene            complement(5001..5381)
                     /locus_tag="SMD11_RS10550"
                     /old_locus_tag="SMD11_2157"
     CDS             complement(5001..5381)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982574.1"
                     /locus_tag="SMD11_RS10550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2157"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_087926206.1"
                     /sec_met_domain="melC (E-value: 6.6e-35, bitscore: 118.9,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLTRRRMLGRTAAVAAGFALVAPAAQAMAADGATSAAGHEHDH
                     HTGGGHQPFDEVYEGRRIEGRLTAGGGHHDFGIAVFVDGRPLHIMPRGNGWISVMNHYE
                     VFDSPYEVTRAAVRALRGVNLV"
     misc_feature    5421..5434
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.29"
                     /tool="antismash"
     misc_feature    complement(5424..5438)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(5624..5637)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.71"
                     /tool="antismash"
     misc_feature    5625..5638
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.72"
                     /tool="antismash"
     misc_feature    5626..5639
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.9"
                     /tool="antismash"
     misc_feature    5628..5641
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.96"
                     /tool="antismash"
     misc_feature    5642..5660
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            complement(5814..6839)
                     /locus_tag="SMD11_RS10555"
                     /old_locus_tag="SMD11_2158"
     CDS             complement(5814..6839)
                     /EC_number="2.7.1.11"
                     /GO_function="GO:0003872 - 6-phosphofructokinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983263.1"
                     /locus_tag="SMD11_RS10555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2158"
                     /product="ATP-dependent 6-phosphofructokinase"
                     /protein_id="WP_087926207.1"
                     /transl_table=11
                     /translation="MRIGVLTAGGDCPGLNAVIRSVVHRAVVGHGDEVIGFEDGFKGLL
                     DGRHRKLDLEAVSGILARGGTILGSSRLERARLREACESSKELARDLGIDVLIPIGGEG
                     TLTASKMLSDAGLPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAIDRLKTTAESHQRV
                     MVVEVMGRHAGWIALESGMAGGAHGICLPERAFDPADLVKMVEERFARGKKFAVICVAE
                     GAHPAEGSMDYAKGAIDQFGHERFAGIGTKLATELERRLGKEARPVILGHVQRGGTPTA
                     YDRVLATRFGWHAVEAAHRGDFGKMTALKGTDIKMVPLADAVTELKRVPENRMDEAESV
                     F"
     misc_feature    7156..7172
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.83"
                     /tool="antismash"
     misc_feature    7159..7168
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     gene            7206..9284
                     /gene="pta"
                     /locus_tag="SMD11_RS10560"
                     /old_locus_tag="SMD11_2159"
     CDS             7206..9284
                     /EC_number="2.3.1.8"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pta"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950877.1"
                     /locus_tag="SMD11_RS10560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMD11_2159"
                     /product="phosphate acetyltransferase"
                     /protein_id="WP_087926208.1"
                     /transl_table=11
                     /translation="MTRSVYVTGTDRGDGRQVIELGVMELLTRHVDRVGVFRPLVHGDG
                     PDRLFDLLRSRYRLGQSPETVYGLSYGEASALQAERGTDELVSALVERFLAVAREYEYV
                     LVLGTDYADTSVPDELALNARLANEFGASVITVVSGQDQEAEAVRAEARNAYRAYEALG
                     CDVVALVVNRVAPADREAVAELATSLPVPCYALPEDASLSAPTVGQIVRKLGAEVLLGD
                     DAGLARDVKDFVFGGAMLPVFLPALTDGCLVVTPGDRTDLIIGALAAHSAGAPPIAGVL
                     LTLDERPTADILALAGRLAPGTPVISVPGKSFPTATELFAVEGKLNAASPRKAETALGL
                     FERHVDTAELTNRISVARSGRVTPMMFEHELIERSRSARRRVVLPEGTEERVLRAADVL
                     LRRDVCDLTLLGEEEAIRKRAGELGIDLAEAQLIDPHTSPLRERFAELYAKARAHKGMT
                     VELAHDVVADVSYFGTLMVQEGLADGMVSGAVHSTAATIRPAFEVIKTAPGAQIVSSVF
                     FMCLADRVLVYGDCAVNPDPNAEQLADIAIQSAATAAQFGVEPRIAMLSYSTGTSGSGA
                     DVDKVRRATELVRERRPDLKVEGPIQYDAAVDAAVAATKLPGSEVAGKATVLVFPDLNT
                     GNNTYKAVQRSAGAVAVGPVLQGLRKPVNDLSRGALVQDIVNTVAITAIQAQGEQRA"
ORIGIN
        1 gtcaccgccg cggtcccgct gcgctcggtc ggcttccagt cctcgaacga ccccgcgctc
       61 gcctacgccg cggacctcac ggcgctccgt aaggtggcgg acatccggtt cgtcagcggc
      121 tcccccgccg acgtgcggaa gggcaccgtc gcggtgtccg accaatacgc caaggaccgc
      181 ggcctgaagg tcggttcccc tctgccgatg gacttctacg acggcgagaa ggccaccccg
      241 aaggtcgccg cggtctacgc caagaacgac gtcgtctccg ccgtcctcgc caccccctcg
      301 ctggtggacc cgcacctgga gaaggtgcgt gacgacgagg tgctggtgaa ggccgccccc
      361 ggcaaggccg gcgagctccg cgccaagatc aaggagaccc tcggcggcaa cccgctcatc
      421 aaggtgcaga gccaggagga cctgcgccgc tcggaggccg ggaacatcga cgacatcctc
      481 tacctgatgt acgggctgct gggcatggcc gtcgtgatcg cggtcgtcgg cgtcgtcaac
      541 accctcgcca tgtcggtctt cgagcggacc cgggagatcg ggatgctgcg cgcgatcggc
      601 ctggcccgca cgggcgtcaa gcagatggtg cggctggagt cggtgatgat cgcgatgttc
      661 ggcgcggtgc tgggcgtcgg ggtcggcatc ttcctggcct ggtccggcgg gcacctggtg
      721 cggtcgtcgt tcccgcagta ctcgatgatc gtgccgtggg gccggatcgc cgtgttcctg
      781 ctgatcgcgc tcgcggtggg cgtgctggcc gcggtctggc cggcccgccg ggcggcgaag
      841 ctcaacatgc tggagtcgat cggggcgcag tagccacgga ggacgcacga cagacggcgg
      901 tgggccggga ccccttgcgg aaggggtccc ggcccaccgc cgttccgtgt gcccggcccc
      961 ggcacccacc ccggggtaag cacccacttt tttgtgcgta cttggcgcgg cgcgcggcgt
     1021 cgcgcagtct gatgagggcg cgccgaaccc ctccgacgat cacgatcacc gcacttcagg
     1081 agcacgtaca tgagcagcaa ctcccccgtc tccgtcctgg gcctcggcgc catgggaaag
     1141 gccctggcca ccgccttcct gaccggcggg cacccgacga ccgtgtggaa ccgcacgccc
     1201 ggcaaggccg acccgctcgt cgccctcggc gcggcccgcg ccgccgacgt cacggcggcc
     1261 gtcaccgcga gcgagctggt ggtcgtctgc ctcctggacg acgcctccgt ccacgagacg
     1321 ctggacccgg tcgcggcgga gctcgccggg cgcaccctcg tcaacctcac caacggcacc
     1381 ccggcacagg cgcgcgcgac ggccgggtgg gcggccgcgc acggcatcgc ctacgtcgac
     1441 ggcgggatca tggccgtacc gccgggcatc ggcaccgacc aggcgttcgt cctctacagc
     1501 ggcgcggagg acgccttcgc ggcccaccgg ccggcgctgg agcggctcgg cgcggcgcgc
     1561 ttcgtcggcg cggacgcggg gctggccgcg ctctacgaca tcgcgctgct gagcgggatg
     1621 tacgggatgt tcgcgggcgt cttccacgcc ctggccctgg tcggcacgga gcaggtgccg
     1681 gcggcggagt tcgcgccgct gctgacgggc tggatcggcg cgatggcgac cgcgatcccg
     1741 cacatggccg agcaggccga gtcgggcgac tacacggacg gcgtcgtctc caacgcggcg
     1801 atgcaggcgg cggctttcgg caacctcctg cggacggcgg aggaccaggg ggtcagcggg
     1861 gagctgatcg cgccgctgcg gccgctgctg gaccggctgg tcgcggaggg cggcggggcg
     1921 ggtgacgtga cggggatcgt ggggctcctg acgaagccgg cgtgaccccg tcgtacgcat
     1981 tcgttgtacg aacccgccgc gccggtccgc cgcgagaacc cgtcccgcgg ttccaccacg
     2041 cgagcggccc gtaccccccg gccgtacgga gcggcccgta cgcccccgcc gcacggacca
     2101 ccccgcaccg ccacttcccc cgggcatgcg tccggggggc gaggccgccc cctcctgcgg
     2161 cctcgccccc cggaaccctt cgaccggtcc cccggtcagt accccacggt gaagcgcgcg
     2221 cgccggtgcg cgggcgtctc cacctcgtcc agcagcgcga cggcgtagtc ctcgcccgag
     2281 atgcgggacg cgccctcggt gtcggtcagc aggtcgtcgc cgccgagccg gaacgtcccc
     2341 gtgcgctcgc cgggcaggaa cagcgccgac gggctcagga aggtccagtc cacgccctcg
     2401 ggcagggcgc gcagcgcgtc cagcagctcg acgtgcgcgg acgcctcggg cttccactcg
     2461 tcgcggaagc cgggctggtc gatgacgcgc tcgccgttcg gaaggcgcag gctgccggcg
     2521 ccgccgacga agaccaggcg ggtgccgccc gccgcggtga cgagctcggg cagcagcggc
     2581 agcacggtcc gggccgggag cgcgctgacg acgacgtccg cgccgtccag cagctccggg
     2641 gccggcacgg cgccggcgac gtcggcggac acccggcgca ggccgtcccg ggccggggcc
     2701 tgctcgtcgt ggctgcgggc gacggcggtc acggcgtggc cgcgggtgag cgcctcggcc
     2761 acgatgcggc tgcccgccat gccggtggcg ccgaggaccg tgagcttgac ggaggtggtc
     2821 atgcggggtt tctccaagtc gtacgggtcg ggagtggtca cggccggcgg ccggccggac
     2881 ggggtcagag ctggatgtcg aaggtgacct tcgcctgttc caccgtctcc tggagcacgc
     2941 gcacctggcc gcgggcgttc ttgtacttgc cggtgccgcc ggtgatggcg aactgctcgt
     3001 cgaagaccgg gcccttggcg ttcagcttcg cggtgcccga cgtggtgatc ttgttgccgt
     3061 cgcccaggtc gtagacgaag gtcagcatct cggacgtacg cggctcggcg tcggtggaga
     3121 tgccctggaa gctgctggtc ccgagggtgc ggccgtcggt gccgacgagg tcgccggtgc
     3181 cgatcagctg gtcgccgagt gccgagtcgg ccggggcgac gtcgaccatg ttgatcgagg
     3241 tgccgcgctc gacggcctcg atcgtgaccg tgcgcgggcc ggtgtacgcg gggctcgcgg
     3301 cgcccgcggt ggccgggctc agggcgaggg cggcaccggc gataccggcg gcggcgacgg
     3361 tgagacccag ggcgggaagc gcgcgcttgc gcatgatcgg actccaaacc ttgcgaaaag
     3421 aaatatctgc ttcggcagac aatatgtctg ccgaagcaga tactgcaagg gaaggttctg
     3481 ccgtcgggtg gctttctgcg accctggtgg ggtgaaggag cgcatgctga atgacgacga
     3541 cgtgacgctg tacggcctgt tcgtggaggc cttcagccga ctgaaaccgc tggtccacga
     3601 ggatctcggg gtaccggaca cctggttcga ggtactgctg cgcctgggcc ggacccccgg
     3661 ccacgccctg cggatgagcg acctggcgac cgcggtggcc ttcagctcgg gcggcttcac
     3721 ccggctcgcg gaccgcatgg aggaggcgga gctgatccgc cgcgaaccgg acccggacga
     3781 ccggcgggcc gcgctggcgg tgctgacacc ggcgggcgag aaggccctgg accgggcgct
     3841 gtcacggcat ctcgcgcacc tgcgcacgca cgtgagcggc cggctgtcgg aggaggaccg
     3901 gcgcgcgttc gaacgggtgc tgcggctgct gcgggacggc gacgcgtagg cgcgtgggcg
     3961 tgtgcgcaca cagacacgcg ggcacgcggg cgacatcggg cccccgcccc ggacccgggc
     4021 acccgggaaa aacagcggtg cgccgcaccg cttccgcggt acggcgcacc cgaagccccc
     4081 cctcgggccc cggccaccga ctacacgtcg gtgtcgtact tgtagaactt cttgtggtcg
     4141 atgaggtcgg ccgggacgac ccgcttgccc tgctcgatcc acggcttcat cggctggttc
     4201 agggcgacga tgtccttgac cggctcgacc ggcaggtacg cgggcacctt cgggtggcgc
     4261 ttctgccagt ccgcccacag cttgtcgatg aagcagtgga gcagccagaa gacggggtcg
     4321 ttgggcgaca tccccgtgtt catgtggccg ccgatccagc ggtggacggc gttgtgcggg
     4381 ccggtgttgc cgttggccca gccctcgacg aggttacgga aaccggcctt ggaggtggag
     4441 ttccagggcg cctcgtcgta gtacggggcg gccagcgcgg cctcgaccgt ggcggccgtg
     4501 ggcagctgcg gcgtcccctt gttcttgccg atctcgcgca tcaggaaggg gcgctcgtcg
     4561 gccttgaagt agatcggcca gcggccgccg ctgtaggcga acggaccgtc catgacctgg
     4621 gcgtcccgct cccggccggt gccgcccagg aagtcggggg cgaagatcgg gtcggacagc
     4681 gagcggttga ccgtgaagtc ccagtacggc agcgtgaccg ccgggttgac ggactggagg
     4741 tcccgctcga agtcgagcag gaactggcgg tgccagggga ggaacgacgg ggagacgtgg
     4801 cccgtgcgct cctggtcgtc caggtcgctc atcacgaagc ggtcgtggat ctcgacgtac
     4861 ttgtcgtaac cgccgcggcg cttgagctcc agcagggcct cgacgaagtc gcgccgctcg
     4921 gccttgctca gctttgcctg gttcttgcga actgccataa aaattcagac ctttaccgtg
     4981 tcacgaacga agggacgagc tcagacgagg ttgacgccac gcagcgcgcg cacggcggcg
     5041 cgcgtcacct cgtacggcga gtcgaagacc tcgtagtggt tcatgacgct gatccagccg
     5101 ttgccgcgcg gcatgatgtg cagcgggcgc ccgtcgacga acacggcgat gccgaagtcg
     5161 tggtggccgc cgccggcggt gagccggccc tcgatgcgac ggccctcgta gacctcgtcg
     5221 aacggctggt ggccgccacc ggtgtggtgg tcgtgctcgt gcccggcggc ggacgtggcg
     5281 ccgtccgcgg ccatggcctg cgcggccggt gccaccagtg cgaatcctgc ggccaccgcg
     5341 gccgtacggc ccagcatgcg gcggcgggtg aggtcggaca cccggttccc ccttgtgttc
     5401 acgctctgag gacccccctc agaagaaacg tttcttccgg ccgggcggag agggtgcgca
     5461 aggcgtgcgc ggcatgcttc ggcacctggg ccgtgaccgc cgatcccccc gatccccccg
     5521 atcggcgcgt gcggcggacc cggtgggcgc gccgcagatg atcaagaacg taacagacct
     5581 gagggaagag ccggacatgt ggcgagataa agccaatatg agggtgtatt aaacaaaaac
     5641 actctgcata aataacctgc ggtaaggcat gcagcggagc ggaagatctc tttctctccg
     5701 ccttgaattc ggtatatttt cctgccgtat cgacgaaacg tggcatgcct cacgaaatga
     5761 cgaagccccc gccgacctgg tcggcggggg cctgtcgaag acctgcgggc gggctagaag
     5821 accgactcgg cctcgtccat ccggttctcc gggacccgct tgagctcggt gacggcgtcc
     5881 gcgagcggca ccatcttgat gtcggtgccc ttcagcgccg tcatcttgcc gaagtcgccc
     5941 cggtgggcgg cctcgacggc gtgccagccg aagcgggtgg cgagcacgcg gtcgtacgcg
     6001 gtgggggtgc cgccgcgctg gacgtggccg aggatgaccg ggcgggcctc cttacccagg
     6061 cggcgctcca gctcggtcgc gagcttggtg ccgatgccgg cgaagcgctc gtgaccgaac
     6121 tggtctatgg cgcccttggc gtagtccatg gagccctcgg ccgggtgggc gccctcggcg
     6181 acgcagatga cggcgaactt cttgccgcgg gcgaagcgct cctccaccat cttgaccagg
     6241 tccgccgggt cgaaggcgcg ctcgggcagg cagatgccgt gggcgccgcc ggccatgccg
     6301 gactccagcg cgatccagcc ggcgtgccgg cccatgacct cgacgaccat gacgcgctgg
     6361 tgcgactcgg cggtggtctt gaggcggtcg atggcctcgg tggcgacacc gacggccgtg
     6421 tcgaaaccga aggtgcggtc cgtggaggag atgtcgttgt cgatggtctt cgggacgccg
     6481 accaccggca ggcccgcgtc ggagagcatc ttggacgcgg tgagcgtgcc ctcgccgccg
     6541 atcgggatca gcacgtcgat gcccaggtcg cgggcgagct ccttggagct ctcgcaggcc
     6601 tcgcggagcc gggcgcgctc caggcgcgag gagccgagga tggtgccgcc gcgggccagg
     6661 atgccgctga cggcctccag gtccagcttg cggtgccggc cgtcgagcag gcccttgaag
     6721 ccgtcctcga agccgatgac ctcatcaccg tggccgacga ccgcacggtg cacgaccgag
     6781 cggatgacag cgttcaggcc ggggcagtcg ccgcctgcgg tgagaactcc gatgcgcatc
     6841 tggctgtgtc tcctgctcgc tactggtaca tgtgagccga accgattgtt tcacgggccg
     6901 gggggtagtg gcgcaacccc cggtaatcct gcctcaggcc ggaccccggc cggccccgcg
     6961 ccggggggct ggaggcgtcc ggcccgggcc cggcccacag ccggcacgga accgaaccgg
     7021 ccgtggcttc cgtcagagaa agtccctgac caggcacgga gccgctgcgg aggatccggg
     7081 gcgccccgtc gagggcactg acgcgcgcct taaccagcgg cgcaggtatt gtcaagaggg
     7141 caagcccacc ataacgggta atttttgaac cgcatgaaca cggcgatgga gcaaggagag
     7201 cacgcgtgac gcgcagcgtg tacgtgaccg ggaccgaccg gggtgacggc cgccaggtca
     7261 tcgagctggg agtcatggag ctcctcaccc gccatgtgga ccgggtgggc gtcttccgcc
     7321 cgctcgtcca cggcgacggc ccggaccggc ttttcgacct gctgcggtcc cgctaccggc
     7381 tcggccagtc accggagacc gtgtacggcc tgagctacgg cgaggcgtcc gccctccagg
     7441 ccgagcgcgg cacggacgag ctggtctcgg ccctggtgga gcgcttcctg gcggtggccc
     7501 gggagtacga gtacgtgctg gtgctgggca ccgactacgc cgacaccagc gtcccggacg
     7561 agctggcgct caacgcgcgg ctggcgaacg agttcggcgc ctcggtgatc accgtggtca
     7621 gcggtcagga ccaggaggcc gaggccgtcc gcgccgaggc ccgcaacgcc taccgcgcct
     7681 acgaggcgct gggctgcgac gtcgtcgcgc tcgtcgtcaa ccgagtggcc ccggccgacc
     7741 gcgaggccgt cgccgagctc gccaccagcc tgccggtgcc ctgctacgcg ctgcccgagg
     7801 acgcctcgct ctccgcgccg accgtgggcc agatcgtccg caagctgggc gccgaggtgc
     7861 tgctcggcga cgacgccggg ctcgcccgcg acgtgaagga cttcgtcttc ggcggcgcga
     7921 tgctcccggt cttcctgcca gccctgaccg acggctgcct ggtcgtgacc cccggcgacc
     7981 gcaccgatct gatcatcggc gcgctggccg cgcacagcgc gggcgcaccg ccgatagccg
     8041 gtgtgctgct caccctggac gagcggccga cggcggacat cctggcgctg gcgggccggc
     8101 tcgcccccgg caccccggtg atctccgtgc cgggcaagtc cttcccgacc gccaccgagc
     8161 tcttcgcggt cgagggcaag ctcaacgccg cctcgccgcg caaggcggag acggccctcg
     8221 gcctcttcga gcggcacgtg gacacggcgg agctgacgaa ccgcatctcc gtggcccgct
     8281 ccggccgcgt caccccgatg atgttcgagc acgagctgat cgagcgctcc cgctccgccc
     8341 gccgccgggt ggtgctgccc gagggcaccg aggagcgcgt gctgcgcgcc gccgacgtgc
     8401 tgctgcgccg tgacgtctgc gacctcaccc tgctgggcga ggaggaggcg atccgcaagc
     8461 gcgccgggga gctgggcatc gacctggccg aggcgcagct gatcgacccg cacacctcgc
     8521 cgctgcgcga gcgcttcgcg gagctctacg cgaaggcgcg cgcccacaag ggcatgaccg
     8581 tcgagctggc gcacgacgtc gtcgccgacg tgtcgtactt cggcacgctg atggtccagg
     8641 agggcctggc cgacggcatg gtctccggcg cggtgcactc caccgcggcg accatccgcc
     8701 cggccttcga ggtcatcaag accgcgccgg gcgcgcagat cgtctcctcg gtcttcttca
     8761 tgtgcctggc cgaccgggtc ctcgtctacg gcgactgcgc cgtcaacccg gacccgaacg
     8821 ccgagcagct cgcggacatc gccatccagt ccgccgcgac cgccgcccag ttcggggtgg
     8881 agccgcggat cgcgatgctg tcgtactcca ccggcacctc cgggtccggc gcggacgtcg
     8941 acaaggtccg ccgggccacc gagctcgtcc gggagcgccg tcccgacctc aaggtcgagg
     9001 gcccgatcca gtacgacgcc gccgtcgacg ccgccgtcgc ggcgaccaag ctgccgggct
     9061 ccgaggtcgc cggaaaggcc accgtgctgg tcttcccgga cctcaacacc gggaacaaca
     9121 cctacaaggc cgtgcagcgc tcggcgggcg ccgtcgcggt cggcccggtc ctccagggtc
     9181 tgcgcaagcc ggtgaacgac ctgtcgcgcg gcgccctggt ccaggacatc gtgaacaccg
     9241 tggccatcac ggccatccag gcgcagggtg agcagcgcgc ctgacacccg tacggtcgta
     9301 cgggggctgc ccggcccccg tacgaccggc cccggggccg cggtgaccgc cgtggccccg
     9361 gggccggcag tgaccgccac cgcccccacg ccccacatcc cccacaaccg acccggaaag
     9421 cccttcatga ctgccaaccc cacccgcgtc ctcgtcctca actccggctc ctcgtccgtc
     9481 aagtaccagc tgctcgacat ggccgacggc gcccggctgg ccgtcggtct ggtggagcgc
     9541 atcggtgagg agacctcccg cctcgcgcac accccgctcg ccacgggcgg cgacaagcgc
     9601 gagaaggagg cgccgatcgc cgaccacgag gccgcgctga aggccgtcgc ccaggagctg
     9661 gccgcggacg ggctgggcct ggactcgccg gagctcgccg cgatcgggca ccgggtcgtg
     9721 cacggcggcc agaagttcac cgccccgacc gtgatcacgg acgaggtcgt cgcggagatc
     9781 gagcggctga tcccggtggc gccgctgcac aaccccgcca acatcacggg catccgcacc
     9841 gcccaggcgc tccgccccga cctcccgcag gtcgcggtct tcgacaccgc cttccacacg
     9901 acgatgccgg agtcggccgc ccgctacgcg atcgacgtgg agaccgcgga cgcccaccgc
     9961 atccgccgct acggcttcca cggcacctcg cacgcctacg tctcccgcga gaccgccaag
    10021 ctgctgggca aggacccctc cgaggtcaac gtgatcgttc tgcacctggg caacggcgcc
    10081 tcggcctcgg ccgtgcgcgg cggccgctgc gtggacacct ccatgggcct caccccgctg
    10141 gagggcctgg tcatgggcac ccgctcgggt gacatcgacc cggcggtcat cttccacctg
    10201 gcccgcaacg gcgggatgtc cgtcgacgag atcgactcgc tcctgaacaa gaagagcggt
    10261 ctgatcggtc tgtgcggcga caacgacatg cgcgagatcc gccggcgcat cgacgagggc
    10321 gacgagcgcg cggcgctggc cttcgacgtc tacgtgcacc ggctgaagaa gtacatcggc
    10381 g
//
