LOCUS       NZ_KZ195574            21119 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195574
VERSION     NZ_KZ195574.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS113
  ORGANISM  Streptomyces sp. CS113
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 78.17x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188365.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:31:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,790
            CDSs (total)                      :: 7,719
            Genes (coding)                    :: 7,614
            CDSs (with protein)               :: 7,614
            Genes (RNA)                       :: 71
            rRNAs                             :: 2, 1 (5S, 16S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 81 of 105
            Pseudo Genes (internal stop)      :: 4 of 105
            Pseudo Genes (multiple problems)  :: 15 of 105
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:56:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8224629
            Orig. end                         :: 8245748
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195574.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..21119
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="32"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21119
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21119
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11119](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11119
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            323..1795
                     /locus_tag="B9W62_RS37180"
                     /old_locus_tag="B9W62_37220"
     CDS             323..1795
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049124.1"
                     /locus_tag="B9W62_RS37180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37220"
                     /product="MFS transporter"
                     /protein_id="WP_087811299.1"
                     /transl_table=11
                     /translation="MSSARTTPTSPPWYREITREKWKSFFAAWIGYLLDGFDFVLITLV
                     LTEIADDFGLSTVESASLVSGAFITRWLGGAVLGALGDRYGRKSAMVASILLYSVGTFA
                     CGFAWDYTSLFTARLLIGMGMAGEYSASATYVLESWPARLRNRASGFLISGFSLGGVLA
                     AEVYEHVVPGHGWRWLFYIGLFPVVVALWVRRALPEADDWEARVGARGERPNPFRPLFA
                     DRRRATVNTVLTVVATGSLFAVFTPLGAGAVPVLSVLATACLIAFAVQLGGRRRWVLFV
                     ALCVTVFCAFLYSWPVQALLPTYLKTELGFSPAQVSDALYYAGFGTMAGCIVTGFIGDR
                     FGTRRAYACTLVVGIAFVFPVFAIRDSQLQLGILLFLMLACMQGISGLLPKFIAGHFPT
                     ETRAASLGFTYNVGALGGAVAPVLGARLASTMSLGQSLAVLTFSLTLVVIVLIGFDVPS
                     RLNRLVDKEAVPDYLAAEAAVPDAAGRIRPTP"
     gene            1893..2258
                     /locus_tag="B9W62_RS37185"
                     /old_locus_tag="B9W62_37225"
     CDS             1893..2258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971684.1"
                     /locus_tag="B9W62_RS37185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37225"
                     /product="transglycosylase family protein"
                     /protein_id="WP_087811300.1"
                     /transl_table=11
                     /translation="MISRRSDRRSDVRGSRGRRVRTAAVILVAATALGATGEAVAAPSA
                     PSRTDWDAIAACESSGNWQANTGNGYYGGLQFARSSWIAAGGLKYAPRADLATRAEQIA
                     VAERLARMQGMSAWGCA"
     gene            complement(2452..3291)
                     /locus_tag="B9W62_RS37190"
                     /old_locus_tag="B9W62_37230"
     CDS             complement(2452..3291)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388049.1"
                     /locus_tag="B9W62_RS37190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37230"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087811301.1"
                     /transl_table=11
                     /translation="MTAQTASSQADETGAAVLRLRDVGVRRFTTDQLILDGIDWTVRPG
                     EHWALLGANGAGKTTLLRLLGAVMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYDEEVRLRARDLLTELGVKELADRPYGVCSGGQRA
                     RVLIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLAEGRPRLATVTVTHHLEELF
                     PAVSHALLLREGRTLSRGAVDEVLTDSRLTACFGRDITVARRDGRWSAYSGRRVAGT"
     misc_feature    3312..3327
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            complement(3861..4589)
                     /locus_tag="B9W62_RS37200"
                     /old_locus_tag="B9W62_37240"
     CDS             complement(3861..4589)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016328090.1"
                     /locus_tag="B9W62_RS37200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37240"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_179235859.1"
                     /transl_table=11
                     /translation="MRTTRLVPALLAALVAALLTALALAPSASAVEPRPGDGGPQPIIG
                     GGYAQNAPWAARLFSNGQQTCTSTIISPTWILTAKHCVSGGNLSFRIGSLDQGSGGTVA
                     NGVQTVTSSSADLALVRLDRSVSASYAQLGRPGTVRVGQTVQVYGWGATSRCGSEINCQ
                     SQYLKVANLSVTRGCYDAYYGQAICARPGDGITAGGDSGGPMMAGGVQVGVASTSDRQT
                     TTAYTNVTAYRSWIQSVAGV"
     misc_feature    4645..4659
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            complement(4808..5560)
                     /locus_tag="B9W62_RS37205"
                     /old_locus_tag="B9W62_37245"
     CDS             complement(4808..5560)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104742.1"
                     /locus_tag="B9W62_RS37205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37245"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_179235860.1"
                     /transl_table=11
                     /translation="MAAVFTAGVGAGAINSVVGSGTLITFPVLLATGLPPVTATVSNAL
                     GLIPGSISGAIGYREELRGQGRRVLKLVSGALLGGLAGAALLLTLPADAFETIVPVLVG
                     LALLLVAFQPQIGRLVQRRRARNGTSPRRDGGPLLLTGLTLASVYGGYFTAAQGIIYLS
                     LMGMLMDEPLQRLNAVKNVLSAVVNTVAALFFLFAAAFEWTAVGLLAVGSGLGGYVGAK
                     VGRRFSPAVLRALVVTVGTVALAQLLLR"
     gene            5896..7083
                     /locus_tag="B9W62_RS37210"
                     /old_locus_tag="B9W62_37250"
     CDS             5896..7083
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="B9W62_RS37210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37250"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_087811305.1"
                     /transl_table=11
                     /translation="MTEYTGNPLLWVALVALVAAAVLISRQRRAARALRQQVQGLRDHY
                     TELENDYGKSVQAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQNKYGDSALLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVDILSQVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINLRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAGLGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     ELLTAMPEKKAPAPAARGTARPVPDTGGPEAAPLTSSQTGDGLPRRRRKRPMAIVPGSA
                     STPRAAGRSDSEQAQIMGAFQRGTQSGRGTEPASPDDAGRTSETPGASSEGHEVS"
     gene            7080..7481
                     /locus_tag="B9W62_RS37215"
                     /old_locus_tag="B9W62_37255"
     CDS             7080..7481
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="B9W62_RS37215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37255"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_087811306.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLAFFCEDPSQTWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGAHS"
     gene            7478..7852
                     /locus_tag="B9W62_RS37220"
                     /old_locus_tag="B9W62_37260"
     CDS             7478..7852
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="B9W62_RS37220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37260"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_087811307.1"
                     /transl_table=11
                     /translation="MTGQDGWQPEAPELVRPYVITKGRGLPDDGDLSLITLVTAADQPQ
                     RPSRLSPEEQSLLDLCSAGYLSVAEIAGHTQFPLGVVRILLASLMEGGHLMTRPPVARA
                     RLADKEILEEVLNGLRAKFG"
     misc_feature    7517..7519
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7827..8420
                     /locus_tag="B9W62_RS37225"
                     /old_locus_tag="B9W62_37265"
     CDS             7827..8420
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="B9W62_RS37225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37265"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_107424240.1"
                     /transl_table=11
                     /translation="MGSAPSLDERDYVRGGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAESVDDLKGVKGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFDGSPLRDERALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRYLLDRTR"
     gene            8435..9784
                     /locus_tag="B9W62_RS37230"
                     /old_locus_tag="B9W62_37270"
     CDS             8435..9784
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388030.1"
                     /locus_tag="B9W62_RS37230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37270"
                     /product="cytochrome P450"
                     /protein_id="WP_087811309.1"
                     /transl_table=11
                     /translation="MNAYDTAPVPPPGCPAHGSGARVPLHGPEFAADPQAYYEYLRHYG
                     AAAPVELAPGVEATLVTDYAAALQLLQDSGTFRKDARRWRAFNEGKISPESPVAPLLAH
                     RPNCMFADGADHLRLRQAVTDSMARVDTRRLSRSTEQISGYLVSQFGARGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGITGMFDGVNAEKAAAVLFQAVGELVALKRRKPGD
                     DVTSWLMQHEARLDDEEMVHQLALLLSAGSEPLRNLLGNTLHRLLTHERYAREGGLIDE
                     AIDDTLWENPPMANFAPHYPAADTELAGQHLRAGDLVLVSFAAANTGPALKASRQAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAIEHLLNELPDLELAVPEDSLTWRPGPFNRALAT
                     LPARFTPVRPARRGEAGPATTAAGQQQTAGAARPAEHKGMWSQFLNWLTR"
     misc_feature    9957..9974
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            10001..11119
                     /locus_tag="B9W62_RS37235"
                     /old_locus_tag="B9W62_37275"
     CDS             10001..11119
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="B9W62_RS37235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37275"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_306426467.1"
                     /sec_met_domain="indole_PTase (E-value: 1.4e-141, bitscore:
                     470.4, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTGAEPQGTPTLGAFTGGQLRRLGSVAGLSHADVETYAQVLTDV
                     LGPEAERPLDLPPPTRTFLSDDHTPVEFSLSFRADAAPVMRVLVEPGCGASSLADNGRA
                     GLAAIRTMARRWHFATDALDELRDLFLPPAPRGPLALWCALELRPGGVPGVKVYLNPAA
                     GGEERSAATVREALHRLGYHRAFDSLPVGSGYPFFALDLGGWAEPRVKVYLYHDNLTAD
                     EAGRLPRMDPGPGPAAVEGFFRTAAALGSDAGGLGGLPGQSCHSFTDLGTARPSGFTLY
                     IPVRDYVRHDGEALTRASEVLRRHGMDASVLDRALPALTERRPEDGAGLIAYLSLAHQG
                     DRPPRVTAYLSSEAYAVRPPAAETVRRPVPVA"
     gene            complement(11228..12526)
                     /locus_tag="B9W62_RS37240"
                     /old_locus_tag="B9W62_37280"
     CDS             complement(11228..12526)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="B9W62_RS37240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37280"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_087811311.1"
                     /sec_met_domain="FMO-like (E-value: 1e-79, bitscore: 267.2,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-08, bitscore:
                     33.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLATGRALKERGISFVCLEKAPDVGGIWRRPGAG
                     ERGPGYQSLHLNTAKQLTGYADFPMPSSYPLYPRHSQFAAYLRSFAEWAGLLDHIELRT
                     EVLSVRQDGDGAWTVVTRGADGVPRSRRFEEVVVASGHNSEPALPDPLPAGAESFAGTI
                     LHSLDYQDGGDFAGRRVVVVGLGASAVDIAADLSRHAARTLLSVRRGLHIVPKQVFGMS
                     LDEIAEAPWWNAMPFAERRQWVEQALLVARGRLSDYGLPEPDHPILSSATTLSDEILSR
                     IRHGAVTPKPAIAAFEGNRVVFADGSAETADAVVYCTGFHMTFPFLPAGCPVAPGGSVE
                     LYRRVVPADRPGLYFVGLVRPAGALTRLVEAQAEWVARLVDGVAVLPGAEEMREEIDTY
                     LAGVVERYGRSRAASIHVDVGPYLAEFRESLPV"
     gene            complement(12638..13984)
                     /gene="paaK"
                     /locus_tag="B9W62_RS37245"
                     /old_locus_tag="B9W62_37285"
     CDS             complement(12638..13984)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (106-352). E-value: 1.6e-20.
                     Score: 64.9. Matches aSDomain:
                     nrpspksdomains_B9W62_RS37245_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971673.1"
                     /locus_tag="B9W62_RS37245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37285"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_087811312.1"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-25, bitscore:
                     87.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPATGAAPAPRPGEPLPHDLLDDAERLSREQLRELQLDRLRA
                     TLRHAYDHVELYRKKFDAAGVTPEDCRSLADLSRFPFTTKADLRDTYPFGMFAVPMSEV
                     RRVHASSGTTGRATVVGYTENDLSMWADVIARSIRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRTS
                     SLKVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHIWEDH
                     FYPEVVDPLTDAVLPEGEEGEIVFTSLTKEALPVIRYRTRDLTRLLPGTARPAFRRMRK
                     VTGRCDDMIILRGVNVFPTQVEEIVLRTPGVAPHFQIRLTERGRMDHMTVRVEARSDAG
                     PEQREAAARAIAQGVKDGVGVTVEVEVVEPESLERSLGKIRRVWDLRGA"
     CDS_motif       complement(12899..12961)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W62_RS37245_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="B9W62_RS37245"
                     /protein_end="362"
                     /protein_start="341"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQVE"
     aSDomain        complement(12929..13666)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W62_RS37245_AMP-binding.1"
                     /evalue="1.60E-20"
                     /label="B9W62_RS37245_AMP-binding.1"
                     /locus_tag="B9W62_RS37245"
                     /protein_end="352"
                     /protein_start="106"
                     /score="64.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VHASSGTTGRATVVGYTENDLSMWADVIARSIRAAGGRPGHKVHI
                     SYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLD
                     EFERQGVDPRTSSLKVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECV
                     ETKDGLHIWEDHFYPEVVDPLTDAVLPEGEEGEIVFTSLTKEALPVIRYRTRDLTRLLP
                     GTARPAFRRMRKVTGRCDDMIILR"
     gene            complement(13981..14421)
                     /gene="paaI"
                     /locus_tag="B9W62_RS37250"
                     /old_locus_tag="B9W62_37290"
     CDS             complement(13981..14421)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010043931.1"
                     /locus_tag="B9W62_RS37250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37290"
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_179236189.1"
                     /transl_table=11
                     /translation="MFFADEASRGLGIELVEHGAGRAVVRMTVTPAMVNGHRTAHGGFL
                     FLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVAVAEERARYGRSGIYDVSVR
                     RGDEVIAEFRGRSRSVRDDGGGRGTHRDTARETPGTTTKESR"
     misc_feature    complement(14482..14497)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(14547..14562)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    complement(14603..14616)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            14635..15621
                     /gene="paaA"
                     /locus_tag="B9W62_RS37255"
                     /old_locus_tag="B9W62_37295"
     CDS             14635..15621
                     /GO_function="GO:0097266 - phenylacetyl-CoA 1,2-epoxidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="B9W62_RS37255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37295"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_087812282.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPDAPDGLQEHFDATIARDQRIEPRDWMPDGYRRT
                     LIRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTQRLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQREMVQDAVDRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEESGHHDFGTPDWDELMR
                     VIKGDGPCNDRRMERRRTAHEEGAWVREAATAHAAKQAARAEKGAAA"
     gene            15618..15920
                     /gene="paaB"
                     /locus_tag="B9W62_RS37260"
                     /old_locus_tag="B9W62_37300"
     CDS             15618..15920
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345122.1"
                     /locus_tag="B9W62_RS37260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37300"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_087811314.1"
                     /transl_table=11
                     /translation="MSTETPGKQGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALTHAR
                     DLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            15930..16757
                     /gene="paaC"
                     /locus_tag="B9W62_RS37265"
                     /old_locus_tag="B9W62_37305"
     CDS             15930..16757
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="B9W62_RS37265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37305"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_087811315.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDPGV
                     LAADCVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQADGT
                     GRDEDAYAYFRDAGDFRNVRLAELPGGDFAFAVVRLLVLSSWRLAHFRRLQAHPDPVLA
                     AVAAKGVKELTYHRQYAAEWCVRLGDGTDESHRRMRTALDEVAPYLGELHTAYDVRDEI
                     ADDLRQVTEAAGLTLPVYRPLPGSGRAGEHTEHLAPLLTELQGIARAHPEATW"
     gene            16751..17266
                     /gene="paaD"
                     /locus_tag="B9W62_RS37270"
                     /old_locus_tag="B9W62_37310"
     CDS             16751..17266
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="B9W62_RS37270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37310"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_179235861.1"
                     /transl_table=11
                     /translation="MVTDGPALLDARRARQVAEQVPDPELPMLTLADLGVLREVEVVAD
                     GTVVASLTPTYSGCPAMAEMRADVDARLREAGYPRVEIRTVLDPPWTSDWITGAGRQKL
                     AEHGIAPPGAAPRGPVSLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACRE
                     PFEYVKEI"
     gene            17266..18372
                     /gene="paaE"
                     /locus_tag="B9W62_RS37275"
                     /old_locus_tag="B9W62_37315"
     CDS             17266..18372
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="B9W62_RS37275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37315"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_087811316.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRTRRRPAFHRLRVAAVERLCADAAAVSFEIPDE
                     LAGEFAFAPGQSLTLRREVDGRDERRSYSICAPAGAAPRIGVRVVPGGLFSAWLVDEVR
                     PGDTVEVMAPTGLFTPDLTTPGHHVLVAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAGRLAALVGSLLDVGS
                     ADHWWLCGPQGMVADAQQVLSGLGVPAERVHRELFYADDEPVREVRHEESGPEGPVSEV
                     TITLDGRSTTSSLSRERSILDGAQQTRPDLPFACKGGVCGTCRALVTDGSADMRRNYAL
                     ETAEVDAGYVLTCQSYPVSEKLTVDYDS"
     gene            complement(18395..19612)
                     /locus_tag="B9W62_RS37280"
                     /old_locus_tag="B9W62_37320"
     CDS             complement(18395..19612)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971665.1"
                     /locus_tag="B9W62_RS37280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_37320"
                     /product="alginate lyase family protein"
                     /protein_id="WP_087811317.1"
                     /transl_table=11
                     /translation="MSSAPTRRHRRSRFVPLATLTAALVGTLLAGPGSAGDRADAAPAA
                     FTHPGVTVSQGQLDFARAKVQAGAQPWKGAFDQMMASRYADLNRAPKPRAVVECGSYSN
                     PNYGCTDEREDAIAAYTNALAWYFTRDEKYARKSIELMDAWSAVLRDHTNSNAPLQTGW
                     AGSSWPKAAEIIKYTYGGTWANSGRFATMLRDVYLPEIINGSNSNGNWELTMTEAAVGI
                     SVFLEDRASYDKALARFRTRTAAYVYLNSDGALPKTVPSQHLDTRDKIVKYWQGQSTFV
                     TGLTQETCRDFTHTGYGISSISHVAETSRIQGQDLYGTDVGERLRHALGFQAKYQQGAA
                     APSWLCGGSLHLGLGPVTEVGYNALHNRLGFAMDNTEALTEHTRPSGTNNLFVAWETLT
                     HGDNPA"
     misc_feature    19634..19645
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    19651..19665
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.58"
                     /tool="antismash"
     misc_feature    19682..19697
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.74"
                     /tool="antismash"
ORIGIN
        1 acctcaccga cgcgggcgac cccgcgctga tgggcggcag ttccagcgcg ctcggcgcct
       61 tcaaggccgc cgcccacctg ctgggcctca tcgactgccc ggccaccgcc gcaccgcagg
      121 tcccgctcga cgccacggcc gtggcccggg tccgcgaccg gctcaccgag gccggactcc
      181 tgtgaccccg ggaccgggcc ggtgaccgcc ggacccggtc ccgcccgccc cgtctcccac
      241 tccgtctccc accccgcccc cgccctcgtc cccgaccgcc ctcgtccccg acgcgcgtct
      301 tccccacccg cataggatcg ccatgtcatc tgcgcgcacc accccgacct cccctccctg
      361 gtaccgcgag atcacccggg agaagtggaa gtccttcttt gccgcctgga tcggctacct
      421 cctggacggt ttcgacttcg tcctcatcac cctcgtgctg accgagatcg ccgacgactt
      481 cggcctgtcg accgtcgagt ccgccagcct cgtctccgga gccttcatca cccgctggct
      541 cggcggcgcg gtgctcggcg cgctcggcga ccggtacggc cgcaagagcg ccatggtggc
      601 cagcatcctg ctgtactcgg tcggcacctt cgcctgcggc ttcgcctggg actacaccag
      661 cctgttcacg gcacggttgc tcatcggcat gggcatggcc ggcgagtaca gcgccagcgc
      721 cacctacgtc ctggagagct ggcccgcccg gctgcgcaac cgcgcctccg gcttcctcat
      781 ctccggcttc tcgctgggcg gcgtcctggc ggccgaggtc tacgagcacg tggtgcccgg
      841 gcacggctgg cgctggctgt tctacatcgg cctgttcccc gtcgtcgtcg ccctgtgggt
      901 acgccgggcg ctgcccgagg ccgacgactg ggaggcacgg gtcggagcga ggggcgaacg
      961 gcccaacccc ttccggccgc tgttcgccga ccggcgccgg gcgacggtca acacggtgct
     1021 cacggtcgtc gccaccggct cgctcttcgc ggtgttcacc ccgctcggcg cgggcgccgt
     1081 gcccgtcctg tccgtcctgg cgacggcctg cctcatcgcc ttcgcggtgc aactgggcgg
     1141 ccgcaggcgg tgggtgctgt tcgtcgcgct ctgcgtcacc gttttctgcg ccttcctcta
     1201 cagctggccg gtccaggcgc tgctgcccac ctacctcaag accgagctgg gcttcagtcc
     1261 ggcgcaggtc agcgacgcgc tctactacgc cgggttcggc acgatggcgg gctgcatcgt
     1321 caccggcttc atcggcgacc ggttcggcac ccgcagggcg tacgcctgca ccctggtggt
     1381 gggcatcgcc ttcgtcttcc ccgtcttcgc catccgggac agccaactcc agctgggcat
     1441 cctgttgttc ctgatgctcg cctgcatgca gggcatctcc gggctgctgc ccaagttcat
     1501 cgccgggcac ttcccgaccg agacccgggc cgcgtccctc ggtttcacct acaacgtcgg
     1561 cgcgctgggc ggcgccgtcg ccccggtgct cggtgcccgg ctggcgtcga ccatgtcgct
     1621 cggccagtcg ctcgccgtgc tcaccttctc gctgaccctc gtggtgatcg tgctgatcgg
     1681 cttcgacgtc ccgagccggc tcaaccggct cgtggacaag gaggcggtcc cggactacct
     1741 cgccgccgag gcggcggtgc cggacgccgc ggggcgcata cggccgacac cgtgaaaccg
     1801 gccacgggca gggggcgaac gcctgctccg accggcccaa gacacggccg ccggtgcggc
     1861 ggcggacggt cacctggtgt aacagtcttc gtatgatcag tagacgaagt gatcgtcgga
     1921 gcgacgtgcg cggttcgcgt ggccgcaggg tccgcaccgc cgcggtgatc ctggtcgccg
     1981 cgaccgccct cggcgcgacc ggcgaagcgg tcgccgcgcc gtcggcgccg tcgcgcaccg
     2041 actgggacgc gatcgccgcg tgcgagtcca gtggcaactg gcaggccaac accggcaacg
     2101 gctactacgg cgggttgcag ttcgcgcggt ccagctggat cgccgcaggc ggcctcaagt
     2161 acgccccgcg cgcggacctg gccacccgtg ccgagcagat cgccgtggcg gaacgcctgg
     2221 cccggatgca gggaatgtcc gcctggggct gcgcctgacc gctgccccgg gcctcgtcca
     2281 cgcggagttg accggggtaa cccgtgggcg tgcacctggg cgtcggtcac cgtgcgtccg
     2341 gtttccgccg ggcggcgcac gggcagtccc cggcggggga gccgggcggc ggccccggac
     2401 gtcgcgcacg acgggacacc cggggccgcc ctcgcccctt cacggggggc gtcaggttcc
     2461 cgcgacgcgg cggcccgagt aggccgacca gcggccgtcg cgccgggcga ccgtgatgtc
     2521 ccggccgaag caggcggtca gccgggagtc ggtcaggacc tcgtcgaccg cgccccggga
     2581 cagggtccgg ccctcgcgca gcagcagggc gtggctgacg gccgggaaca gctcctccag
     2641 gtggtgggtg accgtcacgg tggccagtcg cggcctgccc tcggccagtt ggtgcatcgc
     2701 ctcgaccagg tcctcgcggg agggcaggtc cagggcgttg aacggctcgt ccaggagcag
     2761 cagggccgga tcggccatca gcgcccgggc gatcaggacc cgcgcccgct gcccgcccga
     2821 gcagaccccg tacggccggt cggccagctc cttgacgccg agttcggtca ggaggtcccg
     2881 ggcgcgcaac cggacctcct cgtcgtaggt ccgccacagg ggctgcacgg tgccgctgtg
     2941 gccggtgagc acgaccgcgt gggccgtcag gtcctgcggc acccgctggg cggagttgac
     3001 gtggccgatc cgcgccctca gctcacggac gtccacccgg ccgagccggc tgccgagcac
     3061 ctcgaccgtg cccgtcgtgg ggtgcatcac cgcgccgagc agccgcagca gggtggtctt
     3121 cccggcgccg ttggccccca gcagcgccca gtgctcgccc ggccggaccg tccagtcgat
     3181 gccgtcgagg atcagctggt ccgtggtgaa gcggcgcact cccacgtccc ggagccggag
     3241 tacggccgcc ccggtctcgt cggcctggga gctggctgtc tgggcggtca tgccgtgact
     3301 ccttcacgcg gggcacctct cggtcaccgc gaacactaga tgtactcacc acacgcccgt
     3361 cggggcgtcc gcttcctgga cggcggtcgg cggcactcgg agcgcggacg agcccgcgta
     3421 attcatccgc ggcgccgggc ccggctcccg gcgtggcgcc ggccgagggg acacggaggg
     3481 ggagccaagg agccacggcg tcgtgggacg tcggcgcact gcgcggggag cggacggggc
     3541 ggacggggcg cgtaggcgag ggctcgcggc cctgctggtc gcagcgcagg tcacggctgc
     3601 gccacgttcg acgccgacgc cgacgccgac gccgacgccg acgccgacgc cgacgccgac
     3661 gccgacgccg acgacgtacg gcgggccttc tcccgatgga ccgacgcgtc ggccctgcac
     3721 gcgctgcgcg atacgtaccc ggacgccgtg acgaacggtg gggcgggtcc tcacgggcgt
     3781 ccgggacgag tgcggggtcc tgcgcctgcc tccgcggtga cgggggcagg cgcaggaacg
     3841 gcgcctcagg gcgggaggtg tcagacgccc gccaccgact ggatccagga gcggtaggcg
     3901 gtgacgttgg tgtaggccgt ggtggtctgc cggtcgctgg tcgaggcgac gcccacctgg
     3961 acaccgccgg ccatcatcgg accgccggag tcgccgcccg cggtgatgcc gtcgccgggc
     4021 cgggcgcata tcgcctggcc gtagtaggcg tcgtagcagc cgcgcgtcac gctcaggttg
     4081 gcgaccttga ggtactggga ctggcagttg atctccgagc cgcaccggga ggtcgcgccc
     4141 cagccgtaga cctgcacggt ctggccgacc cggaccgtgc ccggccggcc gagctgcgcg
     4201 taggaggccg agacggagcg gtcgagccgg accagcgcga ggtccgccga ggaactggtg
     4261 acggtctgga cgccgttcgc caccgtgccg cccgagccct ggtcgaggct gccgatccgg
     4321 aaggacaggt tgccgccgct gacgcagtgc ttggcggtga ggatccaggt gggggagatg
     4381 atggtcgagg tgcaggtctg ctggccgttg gagaacagcc tggccgccca gggcgcgttc
     4441 tgcgcgtagc cgccgccgat gatcggctgg gggccgccgt caccgggccg gggctccacc
     4501 gccgaggcgg acggggcgag cgcgagggcg gtcagcaggg cggccacgag cgcggccagc
     4561 agagcgggga cgagtctcgt tgtgcgcaag gctcctcgat tccgacgaca cgcgcatact
     4621 cgcgtgcagg tgtgtggggg cgccccacag catgtcgggc ccgggcaccg gccgggcaat
     4681 cccggcttcg cataacgcgg cgttatgccc gaggggcggg accgggccgg cccaccgcgc
     4741 tgccgggggc gcccggcttc accgcgaggc cgccccgcgg gcgacgacgg gaatggtcag
     4801 acaggcccta gcggagcagc agttgcgcga gggcgaccgt gccgaccgtc acgaccaggg
     4861 cccgcagcac cgcggggctg aagcggcggc ccaccttggc gccgacgtag ccgccgaggc
     4921 ccgaaccgac cgcgaggagc cccacggcgg tccactcgaa ggccgcggcg aagaggaaga
     4981 agagtgcggc gacggtgttg acgacggcgg agaggacgtt cttgaccgcg ttgagccgct
     5041 gtaggggttc gtccatcagc atgcccatca gggacaggta gatgatcccc tgggccgcgg
     5101 tgaagtagcc gccgtagacg ctggccagcg tcagaccggt gaggagcagc gggccgccgt
     5161 cgcggcgggg ggaggtgccg ttgcgggccc ggcggcgctg gaccagcctg ccgatctgcg
     5221 gctggaacgc caccaggagc agcgcgaggc ccaccaggac cggcacgatc gtctcgaagg
     5281 cgtcggcggg cagcgtcagc aggagcgcgg cccccgcgag accgcccagc agcgctccgg
     5341 aaaccagttt caggacgcgc cgcccctgcc cgcgcagctc ctcgcggtag ccgatggctc
     5401 cgctgatgga gccggggatg aggccgagcg cgttggagac ggtcgcggtg accggcggca
     5461 gccccgtggc cagcaggacc ggaaaggtga tcagggtgcc ggagcccacg acgctgttga
     5521 tggcgccggc cccgacgccc gccgtgaaca ccgcggccat ggcctccggt gtcaccccgt
     5581 gccgtcccgc gccgggcccc ggcccgtcgg ccggaaggtg tcttgtgcat ctttcacggg
     5641 gccgactgta cccaccgccc cggtcggcgt gtccgctggt cccaaccggt catgtgtggg
     5701 cgcttcttga cgtcaattca cctgatcatg cggtgatacg atcaccgcgt ttgcggagcg
     5761 ggcggatggg tgaaagacgg catccccgac gtaaggggca gcccgggcag ccactcccgg
     5821 tgcgggcact ccaccgggcc gcccgcacgg acggtaattc agcaagccgg ctgtcagtcg
     5881 cctgaagaga gtcttatgac ggaatacaca gggaacccat tgctctgggt cgccctcgtc
     5941 gccctcgtcg ccgccgccgt gctcatcagc cgccagcgcc gggcggcacg cgcgttgcgg
     6001 cagcaggtcc aggggctcag ggatcactac accgagctgg agaacgatta cgggaagtcc
     6061 gtacaggccg cccaggagcg ggccgaggac gagaccaaga cggtgctgaa gtccgcgatg
     6121 cggacccttc agggactcgc cgccgaacag cagctggtgc tctcccggct acagaacaag
     6181 tacggcgact cggccctcct ccaggacctg ctggagatcg accacaccaa ctcgcagttc
     6241 ggccggcggg cccagtccat cgccgtgctg tgcgacggct ggctcggcgg ccggcgcgac
     6301 accgcctcgg tctacgacgt ggtgcgcagc gcgcaggggc gcatccggca cttccgccgg
     6361 gtggacatcc tctcccaggt cgacttcggc atcaccagcc gggccgtcga gcccgtcgcc
     6421 ctggccctcg ccgagctgct cgacaacgcc accagctact cgagccccga cacggtcgtc
     6481 gagatcaacc tccggaccgt gcccaagggc atctgcgtcg tggtcgacga cgccggtgtc
     6541 ggcatgagcg acgaggagcg ggcccgcgcc gacaagctgc tcgccaccga gcgcgcctcg
     6601 ggcgtggccg gcctcggcaa cccgccgcag ttcggcttcg ccgtcatcgg cctgctgtgc
     6661 gaacgattcg gcttcgaggt gtcggtggac tcctcctccc cctacggagg tgtacgggcg
     6721 gtggtcctgc tgccgcacga actgctcacc gcgatgccgg agaagaaggc gcccgccccg
     6781 gccgcccgcg gcacggcccg gccggtcccg gacaccggcg gaccggaggc cgcgccgctc
     6841 acctcctccc agaccggcga cggtcttccg cggcgccgcc gcaagcggcc gatggccatc
     6901 gtgcccggca gcgcgtccac gccgcgcgcc gcgggccgct ccgactccga gcaggcacag
     6961 atcatgggtg ccttccagcg cggaacgcag tccggccggg gcaccgaacc ggcgagcccg
     7021 gacgacgccg ggcggacgag cgaaacacct ggtgcaagca gcgaaggaca tgaggtctcg
     7081 tgaacgacga tctgtcatgg atgctcgaca gcgccctgga gattcccggg gccctgcacg
     7141 cggtcctgat ctccgccgac ggcctgctga tggcccggac gcaggacttc gacaaggacg
     7201 acgccgaccg ggtcgccgcc gcgatgagcg gtgtgcagtc gctcagccgc accctggcct
     7261 tcttctgtga ggaccccagt cagacctggc ggcagaccct ggtcgagttc gacggcggct
     7321 gggtcttcct gatctcggcc ggcgagggcg cctacctcgg cgtgtccgcc tcccccgagg
     7381 tcgacatggc ggacatcacc ttccggatgc agcaactcgt cgcccagctc ggcaagcggc
     7441 tgacgacacc gccgcgcgag aacctgggtg cccactcatg accggccagg acggctggca
     7501 gcccgaggcg ccggaattag tgcggccgta cgtcatcacc aaggggcgcg gcctgcccga
     7561 cgacggcgac ctctcgctga tcaccctggt caccgccgcc gatcagccgc agcggccgtc
     7621 ccggctgtcc cccgaggagc agagcctgct cgacctctgc tccgccggct acctctcggt
     7681 cgccgagatc gccggacaca cccagttccc gctgggcgtc gtgcggatcc tgctggcctc
     7741 cctgatggag ggcggacacc tcatgacccg cccgccggtg gcccgcgccc gcctcgcgga
     7801 caaggaaata ctggaggagg tgctcaatgg gctccgcgcc aagtttggat gagcgggact
     7861 acgtacgcgg gggagcgacc cagacggcgg tgaagatcct cgtcgtcggg cacttcgcgg
     7921 tgggcaagac caccctcatc ggctcgatct ccgagatcga gccgctgtcc accgaggaga
     7981 cgatgacgca ggccgccgag tcggtcgacg acctcaaggg ggtcaagggc aagaccacca
     8041 ccacggtcgc catggacttc ggccgcctga ccatcagcga ccgcgtcgtg ctctacctct
     8101 tcggcacccc cggccagcag cgcttcgtgc agatgtggga ggacatggcg cgcggcgcgc
     8161 tcggcgccct ggtactggtc gacccggagc ggctggcgga ctccttcccc gtgatcgacc
     8221 tcatcgagca ctacgggctc gactacgcca tcgccgtcaa ccacttcgac ggctcgccgc
     8281 tgcgcgacga gcgggcgctg cgcgaggcgc tcgacctgct cgacgacacc cccgtcgtca
     8341 cctgcgacgc ccgcgacgag aagtcctcgg ccgccgcact gaccaccctc gtccgctact
     8401 tgctggaccg cacccgctag gagctgggag caacatgaac gcctacgaca ccgccccggt
     8461 tccgccgccc ggctgcccgg cccacggctc cggcgcccgg gtgccgctgc acgggccgga
     8521 gttcgccgcc gacccgcagg cgtactacga gtacctgcgc cactacgggg ccgcggcccc
     8581 cgtcgaactg gccccgggcg tcgaggcgac cctggtcacc gactacgcgg cggcgctcca
     8641 actgcttcag gactccggca ccttccgcaa ggacgcgcgc cgctggcggg ccttcaacga
     8701 gggcaagatc agcccggaga gcccggtcgc gccgctgctg gcccaccggc ccaactgcat
     8761 gttcgccgac ggcgccgacc acctcaggct gcgccaggcg gtcaccgaca gcatggcgcg
     8821 ggtcgacact cggcgcctca gccgcagcac cgagcagatc tccggctacc tcgtctccca
     8881 gttcggcgcc cgtggctcgg ccgacctgct cggggactac gccaagcagc tgccgctgtt
     8941 cgtgttcaac gaactcttcg gctgccccgc cgacatcggc gaccgggtgc tgttcggcat
     9001 caccggcatg ttcgacgggg tcaacgccga gaaggcagcc gcggtgctct tccaggccgt
     9061 gggagaactc gtcgcgctca agcggcgcaa gcccggcgac gacgtcacct cctggctgat
     9121 gcagcacgag gcccgactcg acgacgagga gatggtgcac cagctcgccc tgctgctcag
     9181 cgcgggatcc gaacccctgc gcaacctcct cggcaacacc ctgcaccggc tgctgaccca
     9241 cgagcggtac gcccgtgagg gcggcctgat cgacgaggcg atcgacgaca cgctgtggga
     9301 gaacccgccc atggccaact tcgccccgca ctacccggcc gccgacacgg aactggccgg
     9361 acagcacctg cgggcgggcg acctcgtgct cgtcagtttc gccgccgcca acaccggtcc
     9421 cgccctcaag gcgtcccgcc aggcgggcag caaccgcgcg cacctcgcct ggagcgcggg
     9481 cccgcacgcc tgcccgtcca aggaaccggc ccggcacatc accgtcacgg ccatcgagca
     9541 cctgctcaac gagctgcccg acctcgaact cgccgttccc gaggacagcc tgacgtggcg
     9601 tccgggcccc ttcaaccggg ccctggccac ccttccggcc cggttcaccc cggtgcgtcc
     9661 cgcacggcgc ggcgaggcgg ggcccgccac cacggcggcc gggcagcagc agacggcggg
     9721 tgcggctcgc ccggccgaac acaagggaat gtggagccag ttcctcaact ggctcacacg
     9781 gtgatgtgca caacaccctc ccaacccgcc ccattcgcat gaagatcgaa cggcacgggt
     9841 agtgagcaac gcggtattca agttgcttac gagtcaaagg aggtgtcgtg gaccacatat
     9901 ccacgaacgc cgctttcccg gtgccgaacc ccccgatacc cgccccccga ggcgggtatc
     9961 gctttgtgcg gctccggccg gggacgggac ggtgagggcc gtgccgacgg gcgcggagcc
    10021 gcagggcaca cccacgctcg gcgccttcac cggcggccag ctgcgaagac tcggctcggt
    10081 cgccggcctg tcccacgccg acgtcgagac ctacgcacag gtcctgaccg acgtactggg
    10141 cccggaggcc gagcggccac tggacctgcc gccgcccacg cgcaccttcc tgtccgacga
    10201 ccacaccccc gtggagttct ccctctcctt ccgagcggac gcggcgcccg tcatgcgggt
    10261 cctcgtggaa ccgggctgcg gcgcgagcag cctggcggac aacggccgcg ccgggctggc
    10321 ggcgatccgg accatggcgc ggcgctggca cttcgccacc gacgccctcg acgaactccg
    10381 ggacctgttc ctgccgcccg ctccgcgggg gcccctcgcc ctgtggtgcg ccctggaact
    10441 caggcccggc ggggtacccg gcgtcaaggt ctacctgaac ccggcggcgg gcggggagga
    10501 acgttccgcc gcgacggtgc gcgaggccct gcaccggctc gggtaccacc gggccttcga
    10561 cagccttccc gtgggcagcg gatacccctt cttcgccctc gacctcggag gctgggcgga
    10621 accccgggtg aaggtctacc tgtaccacga caacctcacg gccgacgagg ccggacggct
    10681 gccccggatg gacccgggcc ccgggcccgc ggcggtcgag ggcttcttcc gcacggccgc
    10741 ggccctcggc tccgacgcgg gcgggctcgg cgggctgccc ggtcagtcct gccactcctt
    10801 caccgacctc ggcacggcgc ggccgagcgg cttcaccctg tacatcccgg tgcgggacta
    10861 cgtccgccac gacggggagg ccctgacgcg ggcgtccgaa gtgctgcgcc ggcacggcat
    10921 ggacgcctcc gtgctcgacc gcgccctgcc cgccctcacc gagcggcggc ccgaggacgg
    10981 ggcgggcctc atcgcctacc tttccctcgc ccaccagggg gaccggccgc cgcgggtgac
    11041 ggcgtacctc tcctcggagg cgtacgcggt ccggccgcct gccgcggaga ccgtccgcag
    11101 accggtgccg gtggcctgac cgggccgtcc gcgcacgaga gggctcccgg tgcgatccac
    11161 cgggaaccct cggcagggac ctgaccgggc gccgtcgcgg actgtgcggc ggcggccggc
    11221 ggaacactca cacgggcagc gactcccgga actccgccag gtacggaccc acgtcgacgt
    11281 ggatcgaggc ggcccgagac cggccgtagc gctcgacgac gcccgccagg tacgtgtcga
    11341 tctcctcgcg catctcctcg gccccgggca gcacggcgac gccgtcgacg aggcgcgcga
    11401 cccactcggc ctgggcctcc accagccggg tgagggcgcc cgcgggccgc accagtccca
    11461 cgaagtacag accgggccgg tccgccggga cgacccgtcg gtacagctcg accgagccgc
    11521 cgggcgcgac cgggcagcct gcgggcagga aggggaacgt catgtggaaa ccggtgcagt
    11581 agacgaccgc gtcggcggtc tcggcgctgc cgtccgcgaa cacgacccga ttgccctcga
    11641 acgcggcgat cgcgggcttc ggggtcaccg cgccgtgccg gatccggctg aggatctcgt
    11701 ccgagagggt cgtcgcggag gagaggatcg ggtggtcggg ctcgggcagg ccgtagtccg
    11761 acagcctgcc ccgggccacc agcagagcct gctccaccca ctggcgccgc tcggcgaagg
    11821 gcatcgcgtt ccaccacggg gcttcggcga tctcgtcgag ggacatcccg aagacctgct
    11881 tgggcacgat gtgcagcccc cggcgcaccg acagcagggt ccgcgccgcg tgccgggaga
    11941 ggtccgcggc gatgtccacc gccgaggcgc cgaggcccac cacgaccacg cgccggccgg
    12001 cgaagtcgcc gccgtcctgg tagtcgaggg agtgaagaat cgttccggcg aacgactcgg
    12061 caccggccgg aaggggatcg ggcagggccg gttcgctgtt gtggcccgag gcgacgacca
    12121 cctcctcgaa ccggcgggag cgcggtaccc cgtccgcgcc ccgggtgacg accgtccagg
    12181 cgccgtcccc gtcctgacgc acggacagca cctcggtgcg cagctcgatg tggtcgagca
    12241 ggcccgccca ctcggcgaag gaccgcagat aggcggcgaa ctggctgtgc cggggataga
    12301 gcgggtacga ggacggcatc gggaagtccg cgtaaccggt cagctgcttg gcggtgttca
    12361 ggtgcaggga ctgatagccc ggtccacgct cgccggcccc cggccggcgc cagatcccgc
    12421 cgacgtcggg cgccttctcc aggcagacga aggagatgcc gcgctctttg agggcacggc
    12481 ccgtcgccag ccccgacagg cctgcaccga tcacacacac acgcacggga tgtcccccca
    12541 ggatgtactc aacctccccc gatcgtgctc atactgccca tccgtttctt cccgcacacc
    12601 agcacgaccc gcgaacggac gtgtccgtgc tcacgtttca cgcgccccgc aggtcccaca
    12661 cccggcggat cttgccgagc gagcgctcca ggctctccgg ctcgacgacc tccacctcca
    12721 cggtcacgcc caccccgtcc ttgacgccct gggcgatcgc cctggcggcg gcctcgcgct
    12781 gttcgggacc cgcgtcggac cgggcctcga cccgtacggt catgtggtcc atgcggccgc
    12841 gttcggtgag ccggatctgg aagtgcgggg cgacgcccgg agtgcgcagc acgatctcct
    12901 cgacctgggt ggggaagacg ttcaccccgc gcaggatgat catgtcgtcg cagcgcccgg
    12961 tgaccttccg catccgacgg aaggcgggac gtgcggtgcc gggcagcagc cgggtcaggt
    13021 cccgcgtgcg gtagcggatc accgggagcg cctccttggt gagggaggtg aagacgatct
    13081 cgccctcctc gccctcgggc agcacggcgt ccgtgagcgg gtccaccacc tcggggtaga
    13141 agtggtcctc ccagatgtgc agtccgtcct tggtctccac gcactcctgg gccacgcccg
    13201 ggccgatcac ctcggacagg ccgtatatgt cgacggcgtg gatgtccatg cgctcctcga
    13261 tctcgcgccg catctcctcg gtccacggct ccgcgccgaa gatgccgacc ttgagggagc
    13321 tggtgcgcgg atcgacgccc tggcgctcga actcgtcgag cagggtgagc atgtaggacg
    13381 gggtgaccat gatgatctcg ggccggaagt cctggatgat ctgcacctgg cgtgccgtca
    13441 tgccgccgga ggcggggatc accgtgcagc cggcgcgctc ggcgccgtag tgggcgccga
    13501 ggccgccggt gaacaggccg tagccgtagg agatgtgcac cttgtgtccg gggcgcccgc
    13561 cggcggcgcg gatcgaacgg gctatgacgt cggcccacat ggagaggtcg ttctccgtgt
    13621 agccgacgac ggtggcgcgg ccggtggtgc cgctggaggc gtgcacgcgc cgcacctcgg
    13681 acatcgggac ggcgaacatg ccgaaggggt aggtgtcccg caggtccgcc ttggtggtga
    13741 aggggaaccg ggacaggtcc gccaggctgc ggcagtcctc gggcgtcacc ccggcggcgt
    13801 cgaacttctt gcggtacagc tccacgtggt cgtaggcgtg ccgcagggtc gcgcgcagcc
    13861 ggtccagctg gagctcgcgg agctgctcgc gggagaggcg ctcggcgtcg tccagcaggt
    13921 cgtgggggag aggctcgccc ggtcggggtg ccggggccgc cccggtcgcc ggctcgctgc
    13981 tcatcgcgac tccttcgtcg tcgtgcccgg cgtctcgcgc gccgtgtccc tgtgcgtgcc
    14041 gcggccgcct ccgtcgtcgc gcacgctgcg gctgcgcccg cggaactccg cgatcacctc
    14101 gtcgccacgc cgtacgctca cgtcgtagat cccgctgcgt ccgtaccggg cacgctcctc
    14161 ggcgacggcc accagcacgt cgccctcgcg ggccggggcg acgaagacga tgtcggcgcc
    14221 ggccgccacg gtcacggggc cgtggctgtt gcaggcgcag gcgaaggcgg tgtcggccag
    14281 caggaacagg aagccgccgt gggcggtccg gtggccgttc accatcgccg gggtcaccgt
    14341 catgcgcacc acggcccggc cggcgccgtg ctccaccagc tcgatgccga gcccccggga
    14401 ggcctcgtcc gcgaagaaca tcgcctccgt gggcgtctgc tcagtggcct gcgacaccgt
    14461 acccaccacc ttgtctcccg accgaccatt cggttagcgc gcggcaaggt caagttatcc
    14521 cgtcgcgcgg cggcgctgtc aagagtgtga ccggcgggtg tccggctctt gcccggcgcg
    14581 cggaaacacg tcacactgat accgaacgaa tggtcggttg ggaagctggt gacgatgacc
    14641 acgacacacg ccgccgaggc gccgcccccg gacgcgccgg acgggctcca ggagcacttc
    14701 gacgcgacga tcgcgcgcga ccagcgcatc gagccgcggg actggatgcc cgacggctac
    14761 cgcaggacgc tgatccggca gatcgcccag cacgcgcact cggagatcat cggcatgcag
    14821 cccgagggcg agtggatcac ccgggccccg tcgctgcgcc gcaaggcgat cctgttcgcc
    14881 aaggtccagg acgaggccgg acacgggctg tacctgtact cggcggcgga aaccctcggc
    14941 gcggaccgcg acgacctcac ccagcggctg atcgagggcc gccagaagta ctcgtcgatc
    15001 ttcaactacc cgaccctgag cttcgccgac gtcggcgtga tcggctggtt cgtggacggt
    15061 gccgcgatct gcaaccaggt gccgctgtgc cgcagctcct acgggcccta cgcgcgcgcg
    15121 atggtgcgca tctgcaagga ggagtccttc caccagcggc agggctacga actgctgatg
    15181 accatgatgc gcggcaccga cgcccagcgg gagatggtgc aggacgcggt ggaccgctgg
    15241 tggtggccgt ccctgatgat gttcggcccg cccgacgacg cctcgcccaa ctcggcgcgg
    15301 tccatggcct ggaagatcaa gcggcacagc aacgacgaac tgcgccgccg cttcgtcgac
    15361 atgaccgtcc cgcaggccga gaagctcggc gtcaccctgc ccgacccgga gctccgctgg
    15421 aacgaggaga gcgggcacca cgacttcggc acccccgact gggacgagct gatgcgcgtc
    15481 atcaagggcg acggcccctg caacgaccgg cggatggagc ggcggcggac cgctcacgag
    15541 gagggcgcct gggtgcgcga ggcggccacc gcccacgccg ccaaacaggc cgcccgcgcg
    15601 gagaagggag cggcggcatg agcaccgaga cgcccgggaa gcagggctgg ccgctgtacg
    15661 aggtgttcgt gcgcggcaag cgcggcctca accacgtcca cgtcggctcg ctgcacgccg
    15721 ccgacgacgc catggccctc acccacgccc gcgacctcta cacccggcgc aacgagggcg
    15781 tcagcatctg ggtggtgcgc tccgagcaca tcgccgcctc cacccgcgac gagaaggacc
    15841 ccttcttcgc ccccagcgcc gacaaggtct accgccaccc gaccttctac gacatccccg
    15901 acgacgtccc gcacatctag gagcagggca tgagtgacga ccacgtctac ctcaccctgg
    15961 ccgaggggca cgaggacgac acccgctggg cctacggcac cggcttcgag gacccgctgc
    16021 acggcgtcga caccaccgtg cccgagggcg tcgaccccgg tgtactggcc gcggactgcg
    16081 tggccctggc cgacgacgcc ctggtgagcg cccagcggct cgccgagtgg gtcacccgcg
    16141 cgcccgagct ggaggaggag gtggcgctgg ccaacatcgg cctcgacctg ctcggccagg
    16201 cccgcctgct ctactcccga gccgggcagg ccgacggcac cggccgcgac gaggacgcct
    16261 acgcctactt ccgggacgcc ggcgacttcc gcaacgtccg cctggcggaa ctcccgggcg
    16321 gcgacttcgc gttcgccgtg gtccggctgc tggtgctctc cagctggcgc ctggcccact
    16381 tccggcggct tcaggcacac cccgacccgg tgctcgcggc ggtagcagcc aagggcgtca
    16441 aggagctgac gtaccaccgc cagtacgccg ccgagtggtg cgtgcgcctg ggcgacggca
    16501 cggacgagtc gcaccgccgg atgcgcaccg cactcgacga ggtcgccccc tacctcggcg
    16561 agctgcacac ggcgtacgac gtgcgggacg agatcgccga cgacctgcgc caggtcacgg
    16621 aggcggcggg actgaccctg cccgtgtacc gtccgctgcc cggctccggc cgcgccggcg
    16681 agcacaccga acacctggcg ccgctcctga ccgagctcca gggcatcgcc cgcgcccacc
    16741 cggaggcgac atggtgaccg atggccccgc actcctggac gcccgccgcg cccggcaggt
    16801 cgccgagcag gtgcccgacc ccgagctgcc catgctgacc ctcgccgacc tcggtgtcct
    16861 gcgcgaggtc gaggtggtcg cggacggcac cgtggtcgcc agcctgaccc ccacctactc
    16921 gggctgcccg gccatggccg agatgcgggc ggacgtcgac gcacggctgc gggaggcggg
    16981 atatccgcgc gtggagatcc gcaccgtcct ggacccgccc tggaccagcg actggatcac
    17041 cggggcgggc cgccagaagc tcgccgagca cggcatcgcc ccgcctggtg cggcaccccg
    17101 aggcccggtc tccctggtgc tgtcacccac ccgtcccgcc gtgccctgcc cgcgctgcgg
    17161 ctcggcggac accgaggaga cctcccgctt cgccgccacg tcctgcaagg cgctgtggcg
    17221 ctgccgggcc tgccgcgagc cgttcgagta cgtcaaggag atctgatggc cccgaccgcc
    17281 cccgtcccgg cggccccggt gcgcacccgc cgccggcccg ctttccaccg gctgcgcgtc
    17341 gccgccgtcg agcggctgtg cgcggacgcg gcggccgtga gtttcgagat ccccgacgag
    17401 ctggccgggg agttcgcctt cgcgcccggt cagtcgctca ccctgcggcg cgaggtggac
    17461 ggccgggacg agcgccgctc gtactcgatc tgcgcaccgg ccggtgcggc gccgcgcatc
    17521 ggcgtgcggg tggtgccggg cggactgttc tcggcgtggc tggtcgacga ggtgcggccg
    17581 ggcgacaccg tggaggtgat ggcgcccacc ggcctcttca ctcccgacct gaccaccccc
    17641 ggccaccacg tcctggtcgc ggccggttcg ggcatcaccc cgatggtgtc catcgccgag
    17701 tcggtgctcg ccgccgacga ccgttccacc gtcaccctgt tctacggcaa ccgccgcacc
    17761 gacacggtga tgttcgccga cgagctggcc gacctgaagg acctccaccc gacccgcttc
    17821 cacctcgccc atgtgctctc ccgcgagccg cgggaggccg aggtgctctc cggccgcctg
    17881 gacgccggac ggctcgcggc gctcgtgggt tccctgctgg acgtggggag cgcggaccac
    17941 tggtggctgt gcggaccgca gggcatggtc gccgacgccc agcaggtcct gtccggcctc
    18001 ggcgtcccgg cggagcgcgt ccaccgggag ctgttctacg ccgacgacga gcccgtgcgg
    18061 gaagtgcgcc acgaggagag cggccccgag ggccccgtca gcgaggtcac catcaccctg
    18121 gacggccgct cgacgacctc ctcgctctcc cgggagcggt cgatcctcga cggggcccag
    18181 cagacccgcc ccgacctgcc cttcgcctgc aagggcgggg tctgcggaac ctgccgggcc
    18241 ctggtcaccg acggcagtgc ggacatgcgc cgcaactacg ccctcgagac cgccgaggtc
    18301 gacgccggct acgtcctgac ctgccagtcg tacccggtct ccgagaagct gaccgtggac
    18361 tacgacagct gaccggccgt cggcccgcgg ccgctcaggc ggggttgtcg ccgtgggtga
    18421 gggtctccca ggcgacgaag aggttgttcg tgccggaggg ccgggtgtgt tcggtgagcg
    18481 cctcggtgtt gtccatggcg aacccgaggc ggttgtggag ggcgttgtag ccgacctcgg
    18541 tcaccgggcc caggccgagg tggagcgagc ccccgcacag ccagctcggt gcggccgcgc
    18601 cctgctggta cttggcctgg aaaccgagcg cgtgccgcag ccgctcgccg acgtcggtgc
    18661 cgtagaggtc ctgcccctgg atccggctgg tctcggcgac gtgcgagatg gacgagatgc
    18721 cgtacccggt gtgggtgaag tcccggcagg tctcctgggt gaggccggtg acgaaggtgg
    18781 actggccctg ccagtacttg acgatcttgt cccgggtgtc gaggtgctgg ctcggcacgg
    18841 tcttcggcag cgctccgtcg gagttcaggt acacgtacgc ggccgtgcgg gtgcggaacc
    18901 tggccagggc cttgtcgtag gaggcccggt cctccaggaa gacggagatg ccgacggcgg
    18961 cctccgtcat ggtcagctcc cagttgccgt tggagttgga gccgttgatg atctcgggca
    19021 ggtagacgtc gcggagcatg gtggcgaagc ggcccgagtt cgcccaggtg ccgccgtacg
    19081 tgtacttgat gatctcggcg gccttgggcc aggaggaccc ggcccatccg gtctgtagcg
    19141 gcgcgttgct gttggtgtgg tcccggagca cggcggacca ggcgtccatc agctcgatgg
    19201 acttgcgggc gtacttctcg tcccgggtga agtaccaggc cagcgcgttg gtgtaggccg
    19261 cgatcgcgtc ctcgcgctcg tcggtgcagc cgtagttggg gttggagtac gaaccgcact
    19321 cgaccaccgc gcggggcttc ggggcgcggt tcaaatccgc gtaccggctc gccatcatct
    19381 ggtcgaaggc gcccttccag ggctgggccc cggcctgcac cttggcccgg gcgaagtcga
    19441 gctggccctg ggagacggtg actccgggat gcgtgaacgc ggccggtgcg gcgtcggcgc
    19501 ggtcgccggc cgagccggga ccggcgagca gggtgccgac gagcgcggcg gtgagcgtcg
    19561 cgagcgggac gaagcgggat ctgcggtggc ggcgcgtggg agcagaggac atgtgggggg
    19621 tccgtccgtt cgagtatgtg aacgctgggt gttgttctga acgttcgact gggcggtgac
    19681 gataggtaga gaccaatggg ccgtcaagag gccacgcagg aacacgtgga cgtccgggtc
    19741 ggcggcggcc ggcgaacact atgaacgcaa cggccgaagg ggtggctccg gatccggcgg
    19801 gttcctaaca tccccgctcg cagcgcaact tcgcgccggc ccacagcacg tacaggagcc
    19861 gcaccttgac cacacccccc gctcccaggc acgacacccg gcccgcccgc cgcagaggcc
    19921 gcccggcggt ggtcgccgcc gcgctcgccg ccgcgctcct cggcaccctc ggcaacgtct
    19981 ccgccgcccc cgcacgggcg gccggacagc cggcggccgc ggactgcccg cccgcgctcg
    20041 cggagaaggc cacctgctac accggccagg acgcggacgg cgccttctac gcgatggccg
    20101 tgccccaccg ctggaacggg tccctcgtcg tgcacgccca cggcggcccc gacctcggcg
    20161 acgcctcgga ccccgcccgc agcaccgagg acctggaacg ctgggcggtg atggtcgacc
    20221 agggatacgc ctgggccgcc tcctcctacc ggcgcggcgg ctacggggcc cgcatggcgg
    20281 ccgccgacac cgagaacgtg cgccgcctgt tcaccgaacg gttcggccgg cccgaacaca
    20341 cctacctgca cggccagtcc tggggcggga acgtcgccgc caaggtcgcc gagacctacg
    20401 gccggcgccc cggcgcctac gacggggtgc tgctgaccaa cggcgtgctc ggcggcggtt
    20461 cgcgcggcta cgactaccgc gtggacttgc gggtggtcta ccagtactac tgccacaacc
    20521 acccgcgccc gaccgagccg cagtacccgc tgtggcaggg cctgcgcccc ggctccacca
    20581 tgacgaccgc ggggctgcgc gcccgcctgg aggagtgcac gggctacgcc tcggacccgg
    20641 ccgaccggac cgcgctccag cagcgcaacc tcgacgacat cctcgccgtc accggcatcc
    20701 ccgagcgcac cctggaatcc catctgcggt tcgccacgtt cacgttccgg gacatcgtga
    20761 ccaaccggct cggcgggcgg aacccgtgga gcaaccgggg ggtgcgctac tcgggttcgc
    20821 acgacgacaa ggcgctgaac gcgggcgtcg agcgcttctc ggccgacccc accgcacggc
    20881 gcgacctgtc ctacgacagc gacctcaccg gcaaggtctc cctgcccgtg ctcaccctgc
    20941 acgccatcga cgacccgacg gcgttcgtgg agcacgaggc ggcctaccgc gccacgctcc
    21001 gcggggccgg ccgggaacgg aacctcgtcc agaccttcac ccgggaacac gagcacagct
    21061 cgctgagcga ctccgagtac gcgggctccc tcgccgcgct ggactcctgg gtgcgcacc
//
