LOCUS       NZ_KZ195574            21599 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195574
VERSION     NZ_KZ195574.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS113
  ORGANISM  Streptomyces sp. CS113
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 78.17x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188365.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:31:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,790
            CDSs (total)                      :: 7,719
            Genes (coding)                    :: 7,614
            CDSs (with protein)               :: 7,614
            Genes (RNA)                       :: 71
            rRNAs                             :: 2, 1 (5S, 16S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 81 of 105
            Pseudo Genes (internal stop)      :: 4 of 105
            Pseudo Genes (multiple problems)  :: 15 of 105
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:56:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7883103
            Orig. end                         :: 7904702
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195574.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..21599
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="29"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21599
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21599
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11599](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11599
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(18..1631)
                     /locus_tag="B9W62_RS35550"
                     /old_locus_tag="B9W62_35585"
     CDS             complement(18..1631)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="B9W62_RS35550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35585"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_179235824.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9.3e-37, bitscore:
                     125.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQDTPSGPSVPAAARAKIDPAVLKRMDVAEARGDGRVEAAVVLR
                     QGAASPAPGDSAAEVRRELTRDTETGQAPVVDLVEARGDRVLNTFWLKNMVLVSASPDT
                     LRELAALAPVERVIPNFTLKAPPGEAVDKSADAVARATAQQTTWGLAKIGADKVHSDQK
                     ITGEGVRVAVLDTGIDAAHPDLAGKLATADPSDPAHPGGWIEFDADGKPVPGSVPHDSS
                     YHGTHVAGTIAGGDTSGTQIGTAPDAELMGGLVIPGGNGSLAQVIAGMQWAIAPYAADG
                     TPAGEPADVVSMSLGSDGYADELVEPARNILRAGIFPSFAIGNACLQGSASPGNVYESV
                     SVGATDADDNVADFSCGEVVNKTNWSAPPAEWPDTYVVPDVSAPGVDILSALPDGGYGT
                     LDGTSMATPHVSGTVALMLQAQPDLTVDEALSILTGTSQSDDRYGERPNPRYGYGRIDA
                     YAAVREASLRSGVRGTVTDERSGKPLAGVTVARTDTGRAVTTDAAGRFSIRLAPGTHDL
                     ALSRFGYVDTVTRQRVRADR"
     misc_feature    complement(1856..1872)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            1903..2886
                     /locus_tag="B9W62_RS35555"
                     /old_locus_tag="B9W62_35590"
     CDS             1903..2886
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014080.5"
                     /locus_tag="B9W62_RS35555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35590"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_087811028.1"
                     /transl_table=11
                     /translation="MLEPIGLDERDEAVYDALIRRTQATAAELAADCNLTLAAAGRALR
                     SLVGLGLASTVPGRPITYVAVPPDSALEAVLRERERALNGVRSHVSALMSLYRAGSRFA
                     HPGELVEVISGREEVNRNWTQMQRATRTQVRGFDCPPYAAAAGHSEPNPVELELLARGV
                     KYRVLYDSSVLELPGWLEDVTTGIRLGEQARIATGLPTKLAISDDRIAMLPLLRPGDDT
                     VTASYVIHPSPLLDALVALFEAVWERSVQIRPSKPPAGPDPAERLSPDEEKLLTLLASG
                     ATDKSAGRALGWSERTVQRHITKLLRRFGAQTRFQLAMEATRRGWI"
     gene            3016..6780
                     /locus_tag="B9W62_RS35560"
                     /old_locus_tag="B9W62_35595"
     CDS             3016..6780
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031481.1"
                     /locus_tag="B9W62_RS35560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35595"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_143665490.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.9e-56, bitscore:
                     189.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHQSSGRRRRLLVLAATLLVTAATPHLTASADTSSPSGAAATAP
                     SDIVAHPAAGPAESVVTLLTGDKVTITPAAGDGPGTITVEGPDGRPVGARVMTVGGDTY
                     VYPDSARSYLAAGALDQRLFNVTRLVADGYDDARLGRLPLIVTYGGQEAGAATLRGRAE
                     AMPGDITGVRPLTSVNGVALATDREDTGALWSALTGPAGSARDAAPAFKGGVAKVWLDG
                     RAEAVLSDSVARIGAPDVWSGGNTGEGVDVAVLDTGYDPDHPDLKDAVEDSDSFVPGED
                     VTDRNGHGTHVASTIAGSGAASDGKEKGVAPGVDLHVGKVLSDAGSGYDSWIVAGMEWA
                     ARDADARVVSMSLGSSEYADGQTVLARAVDALSEETGALFTIAAGNDGPDAQTVRSPGT
                     ADAALTVGAVDSADAIADFSSRGPRYGDDALKPEITAPGVGILAARSQYDDAGSGSYVT
                     LSGTSMATPHVAGAAALVAAAHPDWTGSRIKDALVSTAKATPDISADDGGNGRVDAAAA
                     ATGTLTATGKADAGIQSPSTDQGTVESAVTWSNTADRPVTVDLAVDAPGVPAGVFTLAQ
                     DRLEIPAHGTASVTLRTDADKAGEARRWTGRLTATADGTVRTRTLLGVSTRQRLAHVRT
                     TITGRSGEPTDGVLTFFREGDEYAGTYLYGYGASDELLPSGRYTVYADFRVEGTHGASS
                     AGYARMVLPQVDITGDTDLTFDGRKLRQISAVTPKKTENLARRLDYHRRFDDGSTVTDS
                     AQIGDGYDSMWTAPTASAGYGEQYLTARWRNQQPLLTVTAGAQEFDDLWILPGSAKLPD
                     GAYDLDLIHPGDGLADDYEGVDAAGKAAVVRWDSGDEDTADGKIRAAQAAGVKLLLFVH
                     DLDGRLRLPIIRSTIEVAGLSRTEGEKLIARVDASGSGSVPLRAVSHPDTDYLYDLVRT
                     WKGAIPADLTYAPKERQLARVETHYRNPDGREVYENRYDIHPWTTYNVATSRLSTAGTH
                     RTDYLTTGSAFAWSEDALLYPIVFSSSDPVRYPAGRTTEAHWFGPVTRPRINSGIQPPT
                     RTGDRIDVAVPAWGDSGGDHANYVGFGSPEPIEQAELYRDGKLLATGSAGVTATVPAAK
                     GTYRLVHTASRQATAEFPYSTATRTEWTFASATPGAGGTAQLPLVQVDYALPTDEAGRA
                     ERDATLLVTPLHLAGGPRAALHTRKVEVSYDDGDTWTTARVSGRGNGKVSVELGAPKSA
                     RYVTLRVHASDSRGNTVTQTVVRAAGIAH"
     gene            complement(6891..7784)
                     /locus_tag="B9W62_RS35565"
                     /old_locus_tag="B9W62_35600"
     CDS             complement(6891..7784)
                     /NRPS_PKS="Domain: Abhydrolase_1 (59-246). E-value:
                     2.6e-11. Score: 35.5. Matches aSDomain:
                     nrpspksdomains_B9W62_RS35565_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606865.1"
                     /locus_tag="B9W62_RS35565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35600"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_306426478.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.9e-17, bitscore:
                     61.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.7e-07, bitscore: 28.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASPSAASQKGGDLPHNSKPTVVLVHGAWADASGWGEVTKSLQA
                     RGYPVVATANPLRSLSGDAAYLAARLKTIKGPVVLVGHSYGGAVITNAAAGNPNVKSLV
                     YIAGFAPDKGESLEQILGRYPGSQLTDDPEAPVPTSLDAVPYGSGSGEVDLYIKPNKFS
                     SVFLSDRLEASEANVLAASQRPTTPVTVGEPSGQAAWKSVPSWFLVATEDRTIGTDNLR
                     FMAERAGSTTVEVDAPHAVLETNPEDVTGLILQAADGSRPSLAKTGSRDHTAWLAGAAV
                     LMTAGGVLVTVRARRS"
     aSDomain        complement(7047..7607)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W62_RS35565_Abhydrolase_1.1"
                     /evalue="2.60E-11"
                     /label="B9W62_RS35565_Abhydrolase_1.1"
                     /locus_tag="B9W62_RS35565"
                     /protein_end="246"
                     /protein_start="59"
                     /score="35.5"
                     /tool="antismash"
                     /translation="LSGDAAYLAARLKTIKGPVVLVGHSYGGAVITNAAAGNPNVKSLV
                     YIAGFAPDKGESLEQILGRYPGSQLTDDPEAPVPTSLDAVPYGSGSGEVDLYIKPNKFS
                     SVFLSDRLEASEANVLAASQRPTTPVTVGEPSGQAAWKSVPSWFLVATEDRTIGTDNLR
                     FMAERAGSTTVEVDAPHAVLETNP"
     CDS_motif       complement(7518..7562)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W62_RS35565_0001"
                     /evalue="3.20E-05"
                     /label="NRPS-te1"
                     /locus_tag="B9W62_RS35565"
                     /protein_end="89"
                     /protein_start="74"
                     /score="16.5"
                     /tool="antismash"
                     /translation="KGPVVLVGHSYGGAV"
     gene            8318..>8947
                     /locus_tag="B9W62_RS35570"
                     /old_locus_tag="B9W62_35605"
                     /pseudo=""
     CDS             8318..>8947
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008747277.1"
                     /locus_tag="B9W62_RS35570"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35605"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLDYPSGIDLSTRSLRNLAGQLASRRQEIGTRWRRLSAGRQALLT
                     LAHLRCGDTYTQLAAGFGIGLATVYRYIRVAIDVLAVLAPTLGGAMATVRTKPYVILVG
                     TVLPVDRISADRPYYSGTKRHHGMNIQVLADPFGRLLCASPALPSAMHDLTAAREQSII
                     DALVRADLKCRADKAYRGAARVVRVPFKGRRLKRWQRRRSRSRRQLR"
     gene            complement(9144..9494)
                     /locus_tag="B9W62_RS40380"
     CDS             complement(9144..9494)
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012923.5"
                     /locus_tag="B9W62_RS40380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_179235826.1"
                     /transl_table=11
                     /translation="MTASVSAAPLDTPPQEWIDLADAEYPNLQEGDFILFPDRGWKFTK
                     LSCGQRPATSDYHVRPQVACDEIAAADGDFNKLPGSQEECEKFNSPLSEPFILETYGKW
                     HARTVAWRKEFD"
     gene            10001..11599
                     /gene="uppS"
                     /locus_tag="B9W62_RS35580"
                     /old_locus_tag="B9W62_35615"
     CDS             10001..11599
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473155.1"
                     /locus_tag="B9W62_RS35580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35615"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_256976692.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-28, bitscore:
                     99.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6e-18,
                     bitscore: 63.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESPELRAAYEVCEAEARQFAVELWAAAETLPVETRRSLYAIASW
                     SAYTDRIIDEGPLEGREERLAQWSADTLADLRAGHSSHPLRRALVDTVRRWGLDEALIE
                     EHLDSARADCAAAPVFETFGDQRRYLRGCSGALAELWVPLLEPRGPEAFRLMSVLGEAC
                     QVADLFEDLPDDLAAGRCYLPRQDLRGLGLDVDDLRRGEREEALNAFVDAQLAHWRGLL
                     EETVLAPSAVGAQYQIFVHTLLLGAQMHFDEVTLLRSRVLTQGLESLVTGDGQMSRRAA
                     RPGAGPTPGHIAVIADGNRRWAEARGLPVDQGHRAGIRAVLRLVNAAQRTGIRHVTVYM
                     FSTENWYRSQGEVAALFDAFADWFARGAQTLHELGVKVRWSGRRDRLKESLASSLELLE
                     SMTANNDKLTLTICLDYGGREELAAAARALAAEAVAGTIRPEQIGMAEVARNLYVPEMP
                     DVDLLVRTCEQRISNFLPWHLAYAELVFDPAPWPDFDLARLRDAVDSYAGRERRFGGDA
                     ELPAQAGNLEPARNG"
     gene            complement(11621..12298)
                     /locus_tag="B9W62_RS35585"
                     /old_locus_tag="B9W62_35620"
     CDS             complement(11621..12298)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039511.1"
                     /locus_tag="B9W62_RS35585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35620"
                     /product="hypothetical protein"
                     /protein_id="WP_087811032.1"
                     /transl_table=11
                     /translation="MSAKRRSVVGAGLSLPLLASFTSAAPDAAASETGVADAAGAGRLG
                     TVSDGWVEVRWTPQGQAVLDREEVVVKPVAPARLVKNAHGTAIRFPLRPSEGDPSLADL
                     QRASGAGRLDGGVVFRTPRASFHVEDLEGFLHNGEVSGTYVANGAEIRHAPVFRPGLAE
                     GRLTTQSVAPGKPMRVKVAEVPLRPTQELLDRFTHTFGKPSFTLDTVLAHVTAEGLYTP
                     PKG"
     gene            12400..12567
                     /locus_tag="B9W62_RS40385"
     CDS             12400..12567
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS40385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179235827.1"
                     /transl_table=11
                     /translation="MRCAAANLARSIAEAGPGPRAVTNDDEECVTIAGGPLVEAAETTR
                     RAPLTVMRAR"
     gene            12610..12822
                     /locus_tag="B9W62_RS40980"
                     /old_locus_tag="B9W62_35625"
     CDS             12610..12822
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015034083.1"
                     /locus_tag="B9W62_RS40980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35625"
                     /product="hypothetical protein"
                     /protein_id="WP_087811033.1"
                     /transl_table=11
                     /translation="MASAPVLVHPPLGTGGGRVAARGQSLGLAHSDGDVVEFLRRVGLE
                     DAEGLLDDPSWVKWRGGRAHHYEAA"
     gene            12935..13504
                     /locus_tag="B9W62_RS35595"
                     /old_locus_tag="B9W62_35630"
     CDS             12935..13504
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012923.5"
                     /locus_tag="B9W62_RS35595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35630"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_087811034.1"
                     /transl_table=11
                     /translation="MFTLRREALLACSAVLLAVPTSMGVASAVPEDEALAATANDPQPP
                     ATDEATDEADDPFAGLGDKEFIIQRTLDGKGGVGMTSIKLRCGDDPASSESLDGLGAHP
                     SPQLACDEIAAAGGDLNKLPGLPDYQCTEEDKAPSDEEAFFMGRGVWNDSKTSFSKSFT
                     NVCDEIRETGHVNQVVAADLKGEHKG"
     misc_feature    complement(13550..13566)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.24"
                     /tool="antismash"
     gene            13576..13752
                     /locus_tag="B9W62_RS35600"
                     /old_locus_tag="B9W62_35635"
     CDS             13576..13752
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS35600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B9W62_35635"
                     /product="hypothetical protein"
                     /protein_id="WP_087811035.1"
                     /transl_table=11
                     /translation="MNDKAIRLDVEDREAIGRLHSMGYPEALCVEAYFACDKNEDRAAD
                     YIAQRLGEEFNDN"
     gene            13922..14676
                     /locus_tag="B9W62_RS35605"
                     /old_locus_tag="B9W62_35640"
                     /pseudo=""
     CDS             13922..14676
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009062325.1"
                     /locus_tag="B9W62_RS35605"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35640"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLVYPSSIDLSNRTLRFLAGQLTAKRRDIGTRWRRLPVARQALLA
                     LAHLRCGDTYAQLAAGFGIGIATVYRYIREAIEVLAALALALTEAMKTSGRRRSSSSTA
                     RCCPSTVSPPTPRTTPGKINATA"
     gene            14683..15042
                     /locus_tag="B9W62_RS35610"
                     /old_locus_tag="B9W62_35645"
     CDS             14683..15042
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677532.1"
                     /locus_tag="B9W62_RS35610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35645"
                     /product="Imm7 family immunity protein"
                     /protein_id="WP_087811036.1"
                     /transl_table=11
                     /translation="MELNDGDETRLRQIVDELRRHIAQMDSPYLLDLRWMNGEPFIHLG
                     GSSNHRSSPNVVELFEHVAMVAPGSYGLLHFDDDEEPDRENEIRVLRLVRGTVTQHREA
                     LLSPYIPTVEDPFTG"
     gene            complement(15058..15938)
                     /locus_tag="B9W62_RS35615"
                     /old_locus_tag="B9W62_35650"
     CDS             complement(join(15058..15578,15578..15938))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558180.1"
                     /locus_tag="B9W62_RS35615"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="B9W62_35650"
                     /product="IS5 family transposase"
                     /protein_id="WP_107424233.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MGRGDLTNEEWRRLEPLLPVGGRRGGRWAGHRRVINGILFRERTG
                     IPWRDLPERFGRWKTVYERHRRWSADGTWERILQAVQAEADAEDRIDWSMVGVDSTSCR
                     AHQHAAGARRKAPRTPKKRSTPRQHRPDEGLGRSRGGLTSKIHLASDGGRRPLALLVTP
                     GQWGDAPQMIPVLERIRVRRTGEGRPRTTPGRLSADKAYSSRRNRRCLRRRRTKHTIPE
                     PRDQRANRRRRGSRGGRPVGFDKERYKRRNEVERTISRLKSFRAVATRFDKRAYVFHGT
                     VTVAAIRLWLRA"
     gene            complement(16081..16275)
                     /locus_tag="B9W62_RS35620"
                     /old_locus_tag="B9W62_35655"
     CDS             complement(16081..16275)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B9W62_35655"
                     /product="hypothetical protein"
                     /protein_id="WP_087811037.1"
                     /transl_table=11
                     /translation="MPATGMTRAQLTGADLTATANVTATSDADVHLHDWQAPISDTEAD
                     RSAAREAGQRHVAWGADLA"
     gene            complement(16257..16397)
                     /locus_tag="B9W62_RS40390"
     CDS             complement(16257..16397)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS40390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179235828.1"
                     /transl_table=11
                     /translation="MTATYQRIQVRIVRVGQDTTHVSVPTYADGQILVPVTTFDLCPPP
                     A"
     gene            complement(16394..16798)
                     /locus_tag="B9W62_RS35625"
                     /old_locus_tag="B9W62_35660"
     CDS             complement(16394..16798)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039348.1"
                     /locus_tag="B9W62_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35660"
                     /product="hypothetical protein"
                     /protein_id="WP_087811038.1"
                     /transl_table=11
                     /translation="MSTPAPDTFDPHAFPAGLLAAQRQAAELYAALRAHQATLPWSREP
                     HDGWPEETERGRENSGRPASPGRTAAEANEFDRLLDELPTATAQVQCHPWWKRCEAEGI
                     KGEAMVAARQALKHAEGAVPLGRSDVETAA"
     misc_feature    complement(16799..16817)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.9"
                     /tool="antismash"
     gene            complement(16845..17201)
                     /locus_tag="B9W62_RS40395"
     CDS             complement(16845..17201)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS40395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179235829.1"
                     /transl_table=11
                     /translation="MSAVTGSVTAPRTLPLGRYDTAGRLRYIGRTTTLPRTTGTALAEL
                     LTTPEARHPWAGRTFSARWGTREVLPVHLIRPDLVVGAEVDVARDAAGRWRHPARLHRT
                     RPDLTPADITPLAP"
     misc_feature    17187..17202
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            complement(<17286..17576)
                     /locus_tag="B9W62_RS41275"
                     /pseudo=""
     CDS             complement(<17286..17576)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013252.5"
                     /locus_tag="B9W62_RS41275"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLQLRNPFAIPPGTRAHARVSLFAETRFCEPARFRLRPHAPGRHR
                     PPPWPYSRRRTALEELFSEHRLTAPLTLCQSTTNPDTARQWLTWTSAGLEGL"
     misc_feature    complement(17565..17567)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17619..18290)
                     /locus_tag="B9W62_RS35635"
                     /old_locus_tag="B9W62_35670"
     CDS             complement(17619..18290)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.5"
                     /locus_tag="B9W62_RS35635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35670"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_218781998.1"
                     /transl_table=11
                     /translation="MIADSAIALADVEGLEAVTIRRLAKQHNVTPTALYWHFKEKDQLL
                     DGMAERLFANVELPPEDSSPWAQQLSAVLAAFLAALRPHPAVAPLLSSRVLASPAGLAL
                     TERTLSLLRLGNLPADRTAEVGGYLLSAVIALVTAEPGREHPSDEEAREDAVRAKRASL
                     TALSPRRYPTVVWCADPLADCVSPDEYYDFNLDMLVGGVTSMARRLAPNEARTASAPHA
                     D"
     misc_feature    18382..18393
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 22.22"
                     /tool="antismash"
     gene            18529..20112
                     /locus_tag="B9W62_RS35640"
                     /old_locus_tag="B9W62_35675"
     CDS             18529..20112
                     /EC_number="1.2.1.79"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136221.1"
                     /locus_tag="B9W62_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35675"
                     /product="succinic semialdehyde dehydrogenase"
                     /protein_id="WP_087811040.1"
                     /sec_met_domain="Aldedh (E-value: 3.5e-134, bitscore:
                     446.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTSRSGTRSENVAEPHLDPALVERLTAAVSASAEPATTRAPFT
                     GAPLAQIPQSTAADVNQAFAAARVAQVEWARLTPKQRALPFARFHDVLLSRQEEILNLL
                     QWETGKARHDAFDEVMEAATASLYAARQAPKVLRTRRRQGAFPVFTRALESFRPKGVVT
                     VITPWNYPLALGLDAIPALLAGNAVVHKPDTQTALSTLWPRMVLEELGLPKGLRQVVLG
                     EPAVIGDALIDGADFVSFTGSTRAGRSIAGRAAERLVGCSLELGGKNPMVVLDDADLDA
                     TVESAVRGCLGNSGQMCVGIERIYVHANVYDGFLARFASRVERMTLRPDFDFATDMGSL
                     TNSRQLAHVQEHVEAALAAGARVVTGGRVRPDLGPLFYEPTILTGVPKGTPVRDEETFG
                     PVVSVYRVDSDDEAVLAANDSPYGLNAAVYSRSEARARTLAARIQAGTVNINEGYASAY
                     ASQGASMGGMKSSGVGRRHGPAGLVKYTEPQTVASQRLLGFDPPFGMSRARQVALFTTL
                     LRILKMLRIR"
     gene            20161..21090
                     /locus_tag="B9W62_RS35645"
                     /old_locus_tag="B9W62_35680"
     CDS             20161..21090
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.5"
                     /locus_tag="B9W62_RS35645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35680"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_087811041.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.7e-08, bitscore:
                     30.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVLVTAATGYLGRAVAQRLQSAGHHVSAMARSEVSLRAVAAAGF
                     RPVRGDITDPLSVRAAVAEVDAVIETAAADNESATEILLEAVAGTAKRYVRTSGTSVFT
                     ELSGGESSDTVHAEDPAFEPIPPVQHRFSLDRRVVAAAASGTHTVVLRPGMIYGGGGSE
                     QLPVLLRAAMRDRVSRYMGSGLNRYPNVFLDDVAQAYVLAVESAPAGGEYNIAADEATM
                     REIAEGIAQVLGLEPAVSATMEEMIEAIGLLYALGLSSNARVDASKIRAELGWTPQGPS
                     LLDDLVHGSYQKVWGHREVSLQTGDVPR"
     gene            21087..21509
                     /locus_tag="B9W62_RS35650"
                     /old_locus_tag="B9W62_35685"
     CDS             21087..21509
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181625.1"
                     /locus_tag="B9W62_RS35650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_35685"
                     /product="hypothetical protein"
                     /protein_id="WP_256976693.1"
                     /transl_table=11
                     /translation="MSGARPIRRTTPLAGEIIATDFVSWSPALRQEFVVNAMNVQVGSE
                     LLSETDELKVWHIHVPPGGRLAAHRHVLDYFWTALTDGVSIQHTDDGTTRRVSYHAGDT
                     RHFAFPGEEYLLHDLCNDGPAELRFLTVEHKLTRFR"
     misc_feature    complement(21518..21528)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
ORIGIN
        1 tccaggcgga cgtcggtcta gcggtcggcg cgcactcgct gccgggtcac ggtgtccacg
       61 tacccgaagc gggacagcgc caggtcgtgg gtgccgggcg cgagccggat cgagaagcgg
      121 cccgccgcgt ccgtggtcac cgcgcggccc gtgtccgtgc gcgcgaccgt gacgcccgcc
      181 agcggcttcc cgctgcgttc gtcggtgacc gtgccccgca ccccgctgcg cagggacgcc
      241 tcgcgcaccg ccgcgtaggc gtcgatgcgg ccgtacccgt agcgggggtt ggggcgctcg
      301 ccataccggt cgtcggactg ggaggtgccg gtgaggatgg acagcgcctc gtcgaccgtc
      361 aggtccggct gtgcctggag catgagggcg acggtcccgg acacgtgcgg tgtggccatc
      421 gaggtgccgt cgagcgtgcc gtagccgccg tcggggagcg ccgacaggat gtcgacaccg
      481 ggggcggaga cgtcgggcac gacgtacgtg tcgggccact cggcgggcgg ggcactccag
      541 ttggtcttgt tgacgacctc accgcaggag aagtcggcaa cgttgtcgtc ggcgtcggtc
      601 gcgccgacgg agaccgactc gtagacgttt ccggggctcg ccgagccctg gaggcacgcg
      661 ttgccgatcg cgaaggacgg gaagattccg gcgcgcagga tgttgcgggc cggctcgacg
      721 agttcgtcgg cgtagccgtc ggagccgagc gacatgctga ccacgtccgc gggctccccg
      781 gcgggggtgc cgtcggcggc gtacggggcg atcgcccact gcatgccggc gatgacctgc
      841 gcgaggctgc cgttgccgcc ggggatgacc agtccgccca tcagctcggc gtcgggcgcc
      901 gtgccgatct gcgtgccgga ggtgtcaccg ccggcgatgg tgccggccac gtgggtgccg
      961 tggtagctgc tgtcgtgcgg caccgatccg ggcaccggct tgccgtcggc gtcgaactcg
     1021 atccagccgc cggggtgggc ggggtcggag gggtcggcag tggccagctt gcccgcgagg
     1081 tcgggatggg cggcgtcgat gccggtgtcg aggacggcca cccggacacc ctcgccggtg
     1141 atcttctggt cgctgtgcac cttgtcggcg ccgatcttgg ccaggcccca ggtggtctgc
     1201 tgggcggtgg cgcgggcgac ggcgtcggca ctcttgtcca cggcctcgcc gggcggcgcc
     1261 ttcagggtga agttggggat gacccgctcg accggggcca gcgccgccag ttcgcgcagg
     1321 gtgtccggcg aggcgctcac caggaccatg ttcttgagcc agaacgtgtt gagcacccgg
     1381 tcgccccggg cctcgacgag atccacgacg ggggcctggc cggtctcggt gtcacgcgtg
     1441 agttcacggc ggacctcggc cgcgctgtcg cccggtgcgg ggctcgcggc gccttggcgc
     1501 aggacgacgg ccgcctcgac gcgtccgtca ccgcgtgctt cggcgacgtc catccgcttc
     1561 agcacagcgg ggtcgatctt cgctcgggcg gccgccggga cggacgggcc ggaaggggtg
     1621 tcctgcgcca tcgcaggagc ggcggtcagc gcggtggcac atatgccgag gacggacaac
     1681 agcgatctgt accggtgttg cccgcgcggc ggacgggccg ggagcggcat gggggcactc
     1741 cttctgcgac gcggattccg cgccaggggg gttggggccg atcacgtagc tcttcgaacg
     1801 ctgacatccg tcgcgaactc ctgacaagat caaccggtgg cgacttcccg tcagccggca
     1861 ggaaaatgac aggtatcgac gacaggagcg aggtggcgga ccgtgctgga accgatcggc
     1921 ctggacgagc gcgacgaagc cgtgtacgac gccctgatcc gcaggaccca ggccacggcc
     1981 gcggaactcg cggccgactg caacctcacc ctcgcggcgg caggccgcgc cctgcggtca
     2041 ctggtcggtc tcgggctcgc ctcgaccgtg cccggacggc ccatcaccta cgtcgccgta
     2101 ccgcccgaca gcgccctgga agccgtactc cgcgaacgtg aacgggcgtt gaacggtgta
     2161 cgttcccatg tctcggccct gatgtccctg taccgggcgg gcagtcggtt cgcacacccc
     2221 ggtgaactgg tcgaggtcat ctcgggccgc gaggaggtca accgcaactg gacgcagatg
     2281 cagcgcgcca cccgcaccca ggtacgcggc ttcgactgcc cgccctacgc ggccgcggcc
     2341 ggccactccg aacccaaccc cgtcgagttg gaactcctcg cccgaggcgt caagtaccgc
     2401 gttctgtacg acagttcggt gcttgaactg ccgggatggc tggaggacgt gacgacgggg
     2461 atacgcctgg gggagcaggc ccgcatcgcc accgggctgc cgaccaagct ggccatttcc
     2521 gacgaccgca tcgccatgct tcccctgttg cgccctggcg acgacaccgt gaccgcctcg
     2581 tacgtcatcc acccctcacc cctgctcgac gcgctggtcg ccctgttcga ggcggtgtgg
     2641 gaacggagtg tgcagatacg gccgtcgaag ccgcccgcag gcccggaccc ggccgagcgg
     2701 ctgtcgccgg acgaggagaa gctgctgacg ctgctcgcct cgggagccac cgacaagtcg
     2761 gcgggccggg ccctgggctg gagtgaacgc accgtgcagc ggcacatcac caaactgctg
     2821 cggcgcttcg gcgcgcagac gcggttccag ttggccatgg aggccacccg tcgcggctgg
     2881 atctgatcct caaatcggct gtgttgcgcc gtagttgcat gctcgctacg gccaccgccg
     2941 ggtcttccca agatcgtggt gcaggactta cattcccgtc ggcctgtaag gaccatccga
     3001 gtcaagggaa tcccgttgac acaccagtca tccggaagac ggcggcgcct gctcgtgctc
     3061 gcggccaccc tcctggtcac cgcggcgacc ccgcacctga ccgcttccgc ggacacctcg
     3121 tcccccagcg gcgcggcagc caccgcacct tctgacatcg ttgcccatcc cgcagccggg
     3181 cccgccgagt ccgtcgtgac cctgctgacc ggcgacaaag tcacgatcac tcccgccgcc
     3241 ggcgacggcc ccggcaccat caccgtggaa ggccccgacg gccggcccgt cggcgcccgg
     3301 gtgatgaccg tgggcggcga cacctacgtc tatcccgact ccgcccgcag ctacctcgcg
     3361 gccggcgccc tcgaccagcg gctgttcaac gtgacccggc tcgtggcgga cggctacgac
     3421 gacgcccgcc tcgggcggct cccgctcatc gtcacctacg gcggccagga ggccggcgcg
     3481 gccaccctgc gcgggcgggc cgaggcgatg ccgggtgaca tcaccggggt gcgcccgctc
     3541 accagcgtca acggcgtcgc gctggcgacc gaccgcgagg acaccggcgc cctgtggtcg
     3601 gcgctgaccg gcccggcggg cagcgcgcgg gacgcggcac cggccttcaa gggcggcgtc
     3661 gccaaggtgt ggctcgacgg cagggccgag gctgtgctga gcgactcggt cgcacgcatc
     3721 ggcgcccccg acgtctggtc cggcggcaac accggcgagg gcgtcgacgt ggccgtcctc
     3781 gacaccggct acgacccgga ccaccccgat ctgaaggacg ccgtcgagga cagcgacagc
     3841 ttcgtccccg gcgaggacgt caccgaccgc aacggccacg gcacgcacgt cgcctccacc
     3901 atcgcgggca gcggtgccgc ctccgacggc aaggagaagg gcgtcgcgcc cggtgtcgac
     3961 ctgcacgtcg gaaaggtgct cagcgacgcg ggctcgggtt acgactcctg gatcgtggcc
     4021 ggcatggaat gggccgcacg ggacgcggac gcccgggtag tcagcatgag cctcggcagc
     4081 agcgagtacg ccgacggcca gaccgtgctc gcccgggccg tggacgcgct cagcgaggag
     4141 accggcgcgc tgttcaccat cgcggccggc aacgacggcc ccgacgccca gaccgtgcgg
     4201 tcgccgggca ccgccgacgc ggccctgacc gtcggcgcgg tcgactccgc cgacgccatc
     4261 gccgacttct ccagccgcgg cccgcgctac ggcgacgacg ccctcaagcc ggagatcacc
     4321 gcgccgggcg tcggcatcct ggccgccagg tcccagtacg acgacgcggg ctccggctcc
     4381 tacgtcactc tcagcggtac gtccatggcg accccgcacg tggccggcgc ggccgccctc
     4441 gtcgccgccg cgcaccccga ctggaccggc agccgcatta aggacgccct ggtcagtacc
     4501 gcgaaggcga cgcccgacat cagcgccgac gacggcggca acggccgcgt cgacgccgcc
     4561 gcggcggcca ccgggaccct caccgccacc ggcaaggcgg acgcgggcat ccagtccccc
     4621 agcacggacc agggcaccgt cgagtccgcg gtcacctggt ccaacaccgc cgaccggccc
     4681 gtcaccgtcg acctggccgt ggacgcaccc ggcgtccccg ccggcgtctt caccctcgcc
     4741 caggaccggc tggagatccc ggctcacggc acggcgagcg tcaccctccg caccgacgcc
     4801 gacaaggccg gcgaagctcg ccgctggacc ggccggctga ccgcgaccgc cgacggtacc
     4861 gtgcgtaccc gcaccctgct cggcgtcagc acccgccagc gcctcgctca cgtccgcacc
     4921 accatcactg gccgttcggg cgaacccacc gacggcgtcc tcaccttctt ccgcgagggc
     4981 gacgagtacg caggcaccta cctctacggt tacggtgcct ccgacgaact cctgccctcc
     5041 ggccgctaca ccgtctacgc ggacttccgc gtcgagggca cgcacggcgc gtcctcggcc
     5101 gggtatgcgc gcatggtcct cccgcaggtc gacatcaccg gtgacaccga cctgacgttc
     5161 gacggcagga agctgcggca gatcagcgcg gtgactccga agaagacgga gaacctcgcc
     5221 cgccgcctgg actaccaccg ccggttcgac gacggctcca cagtcaccga cagcgcccag
     5281 atcggcgacg gatacgacag catgtggacg gccccgacgg cgtcggccgg atacggcgag
     5341 cagtacctga cggcccgctg gcgcaaccag cagccgctgc tgacggtgac cgccggcgcg
     5401 caggagttcg acgacctctg gatactgccc ggctcggcga aacttcccga cggcgcctac
     5461 gacctggacc tcatccaccc cggcgacggt ctggcggacg actacgaggg cgtcgatgcc
     5521 gcaggcaagg ccgccgtcgt ccgctgggac tccggcgacg aggacaccgc ggacggcaag
     5581 atccgggccg cgcaggcggc gggcgtgaag ctgctgctgt tcgtccacga cctcgacggg
     5641 cggctgcgcc tgcccatcat caggtcgacc atcgaggtcg ccggcctgtc ccgcaccgag
     5701 ggcgagaaac tgatcgcccg cgtcgacgcg agcgggtcgg gcagcgtgcc gctgcgcgcc
     5761 gtctcccacc ccgacaccga ctacctgtac gacctggtcc gcacctggaa gggtgccatc
     5821 cccgccgatc tgacctacgc accgaaggaa cggcagctcg cccgcgtcga gacccactac
     5881 cgcaaccccg acggccggga ggtgtacgag aaccgctacg acatccaccc gtggacgacg
     5941 tacaacgtcg ccaccagccg cctgagcacc gcaggcaccc accggaccga ctacctcacc
     6001 accggctccg cgttcgcatg gtccgaggac gcactgctgt acccgatcgt cttcagctcc
     6061 tccgacccgg tccgctaccc cgcgggacgg accaccgagg cgcactggtt cggccccgtg
     6121 acacggccgc gcatcaacag cggcatccag ccgcccaccc gcaccggcga ccgaatcgac
     6181 gtcgccgtcc cggcctgggg cgactccggc ggcgatcacg ccaactacgt gggtttcggc
     6241 agccccgaac ccattgagca ggcggagctg taccgcgacg gcaagctgct ggccaccggt
     6301 tccgccggtg tgaccgcgac cgtacccgcc gccaagggca cctaccgact ggtgcacacc
     6361 gcgtcccgtc aggccaccgc cgagttcccc tactcgaccg ccacccgcac cgagtggacg
     6421 ttcgcctcgg ccacacccgg cgccggtggg acggcccaac tgccgctggt gcaggtggac
     6481 tacgcccttc cgacagacga ggcgggcagg gcggagcggg acgccacgct gctggtcaca
     6541 cccctgcacc tcgcgggcgg cccgcgcgcc gcactgcaca cgcggaaggt ggaggtgtcc
     6601 tacgacgacg gcgatacctg gaccacggcc cgcgtcagcg gccggggcaa cggcaaggtg
     6661 agcgtcgaac tcggcgcgcc gaagtcggcg cggtacgtca cgctgcgggt acacgccagt
     6721 gacagccgcg gcaacaccgt cacgcagacc gtggtgaggg ctgcgggcat agcccactga
     6781 gccgcgggag ggggtaggta ccaagctccc tccccggcga ccacagcctc gcggtcagcg
     6841 ctggagttgg ccgcgaggct tccctcaccg aagaggagat cggccgtgtc tcaggatcgg
     6901 cgtgctcgca ccgtcacgag cacgccgcct gcggtcatga gtactgcagc gccggcgagc
     6961 cacgcggtgt ggtccctcga gccggtcttc gcaagactag gacgtgagcc gtccgcagcc
     7021 tgcaggatca gtccagtgac gtcctccgga tttgtctcga ggacagcgtg tggggcgtcg
     7081 acctcgacgg tggtcgagcc agctcgttcg gccatgaacc ggagattgtc ggttccgatg
     7141 gttcggtcct cagtcgcgac gaggaaccac gacggaacgg acttccacgc ggcctgcccg
     7201 ctcggttccc ccacggtcac gggggtagtg ggccgttgcg aggcggccag aacgttggct
     7261 tcgcttgctt cgaggcgatc gctcaggaac acgctgctga acttgttcgg cttgatgtac
     7321 agatctacct cgccgctgcc gctcccgtac gggacagcgt ccagagacgt cggaactggc
     7381 gcctcggggt cgtcggtgag ctgactgccg ggataccgtc caagtatctg ctccagggac
     7441 tcacccttgt ccggcgcgaa cccggcgatg tagacgagcg acttgacgtt cggattaccg
     7501 gccgcggcgt tggtgatgac tgcgccaccg tacgagtgcc cgacaagcac gaccggaccc
     7561 ttgatcgtct tcagccgggc agccaggtag gcggcatcac cggagagact acgcagtggg
     7621 ttcgcggtgg cgaccacggg atagccccga gcctggaggc tcttggtgac ttcgccccaa
     7681 ccagacgcgt cagcccaggc gccatgcacc aggacgacgg tgggtttcga attgtgtggg
     7741 aggtcgccac ccttctgaga cgctgcggac gggctggcgg ccatcagcgc cgaagcgggt
     7801 aggaggaagg cgagggggag agcctttcga gcagaccgta tgtgattcat gcgcactctt
     7861 cctgtgaggc aacgatcgat cggttcgacc ctccgtgtca cccatgacga cggcactcgg
     7921 accgagccga tcgggtgaag agctggctgc ctactgcccg aaccgtgggc gcctttgctg
     7981 ggctcggact caaacctcca cgatgcctcc atcaatcggg aagcaggggc aaacgcccac
     8041 ccacgagccc tcggcctgct cagaggaccc accggagcat gactggtgcc ccggacaagg
     8101 agagccagac cgtcggcagg ccccagtcga taggcgtgtc cctggcgagg ccgacaggtc
     8161 ccaatcggtg gccggatttc acccggcttg gaatgcacca gtgagcctca tccaacctgc
     8221 tcgtgatgtc cggtagttgg acggtcccgc gacatgaaga agctcctggt agacggtgtt
     8281 tcgaccaaga ttcatcgtgt cccaccagga gctttgcttg cttgactatc cgtcggggat
     8341 cgatctgtcc acccgcagcc tgcggaatct ggctgggcaa ctcgcgtccc gcagacagga
     8401 gatcggtacg cggtggcggc gcctatctgc tggccgccaa gccctgctca ccctggcgca
     8461 cctgcggtgc ggtgacacct atacccagct cgcggccggg ttcgggatcg ggctcgccac
     8521 cgtgtaccgc tacatacgcg tagcgatcga cgtgctggcc gtgctcgcgc cgactctcgg
     8581 cggagcaatg gctacggtcc gtacgaagcc gtacgtgatc ctcgtcggca ccgtgctgcc
     8641 ggtcgaccgg atctccgccg accggcccta ctactccggc acgaagcggc atcacggcat
     8701 gaacatccag gtgttggccg atccgttcgg tcggctgctg tgcgcttcgc ccgcgctgcc
     8761 cagtgcgatg cacgacctga cggcggcccg cgaacaaagc atcatcgacg ccctcgtcag
     8821 ggcggacctc aaatgccggg ccgataaggc gtatcgaggg gcggcccgcg tcgtccgagt
     8881 cccgttcaag gggcgccgcc tcaaacggtg gcagcgccgt cgttcgaggt ctcgccgcca
     8941 gctacgccgt tgacagcaaa cggcgcccct gtctgggagt taatccgcca gctgggagag
     9001 gactcactgt gccggctggc cgcagaagcg acgccttgcc tgaggtccgg gcgagccttc
     9061 tactccggag cgtccgattc cctatggtcc tcgtcgtgga gggaggggaa gacatgccct
     9121 gtgtcacgga tggcatcgca cgtttagtcg aattccttcc tccatgccac cgtgcgtgcg
     9181 tgccattttc cgtaggtctc aaggatgaac ggctcactca agggagagtt gaacttctcg
     9241 cattcttcct ggcttccagg aagcttgttg aagtcaccat ccgccgcggc gatttcgtca
     9301 caggcgacct gcggcctcac gtggtaatcg gaggtcgccg ggcgctggcc gcaggacagt
     9361 ttggtgaatt tccacccgcg gtccggaaaa aggatgaagt ccccttcctg tagattcggg
     9421 tattccgcat cagcgaggtc aatccattcc tgcgggggag tgtcgagtgg ggcagccgag
     9481 acggatgcgg tcattggcgc agacttcagg gcagcggagc aagcaaggag tgcggcacgt
     9541 cgaagcatgg aacgatcctt ggtcggcgga agggcaccac gcatcggaac accacgtgtt
     9601 ccgatgcgtg gtgccgacac gcactcagac cggcgttctc gtggccgctt acagcctgca
     9661 gggtgaacga ggcgggcctt gaagggccgt tcctcgccca ggcccatccg gcgaccctcc
     9721 tcggcgggat cttggtcccg tgcaccgcct ccgccgcggg ccatcacggg tgggccgcgg
     9781 cggcgggccg cggccggcag agatccactc gcagcggggt tggcgaggcc agggtgcgcg
     9841 gtgaggagga tggtgtcgtg ggggtgtgcg cgtcgggcgg tcaggtcagc tgggccggcg
     9901 gtgggtggtt cgcgactgga gcgcctgtgg gtcgttagtg ctggtgatga ctgtggcgag
     9961 tgacaggggt ggtctggcaa tggctgggtg cggtggtggc gtggagtcgc ccgagttgcg
    10021 tgctgcgtac gaggtgtgtg aggccgaggc ccggcagttc gccgtggagt tgtgggcggc
    10081 ggcggagacg ctgcccgtgg agacgaggcg gtccttgtac gcgattgcca gttggtctgc
    10141 ctacacggac cggatcatcg atgagggtcc gctggagggc cgtgaggagc ggctcgcgca
    10201 gtggtcggcc gacactctgg ccgatctgcg cgccgggcac agctcgcatc cgctgcgcag
    10261 ggccctggtg gacacggtgc gcaggtgggg tctggatgag gcgctgatcg aggagcacct
    10321 cgactcggcg cgcgccgatt gtgcggctgc tccggtgttc gagaccttcg gggaccagcg
    10381 gcgctatctg cgggggtgtt cgggggctct ggcggagctg tgggtgccct tgttggagcc
    10441 gcgtgggccg gaggcgttcc ggctgatgtc ggtcctgggc gaggcgtgcc aggtggcgga
    10501 tctgttcgag gatctgccgg atgatctcgc ggccggccgc tgctacctgc cccggcagga
    10561 cctgcgcgga ctggggttgg acgtcgatga ccttcgacgc ggtgagcggg aggaggcatt
    10621 gaatgcgttc gtggacgcgc agcttgcgca ctggcgtggg ctgcttgagg agactgtcct
    10681 ggccccctcg gccgtgggag cccaatacca gatcttcgtg catacgttgc tgctcggcgc
    10741 gcagatgcac tttgacgagg tgacgctgct gcgatcccgg gtgctgacac aggggctgga
    10801 gtcgttggtg acgggggacg gccagatgtc ccgccgtgca gcccggccgg gcgcggggcc
    10861 gacacccggc cacatcgcgg tgatcgcgga cggcaatcgg cgctgggccg aggcacgcgg
    10921 tcttcctgtg gaccaggggc accgtgcggg tatccgcgcg gtgttgagac tggtcaatgc
    10981 ggcgcagcgg acgggcatcc ggcatgtgac cgtgtacatg ttctccacgg agaactggta
    11041 tcgctcgcag ggcgaagtgg cggccctgtt cgatgcattt gccgactggt tcgcccgggg
    11101 tgcgcagacg ctgcacgagc tgggtgtgaa ggtgcgctgg agcgggcgcc gggaccggct
    11161 caaggaatcg ctcgcgtcct cgctcgagct gctggagagc atgacggcga acaatgacaa
    11221 gctcaccctc accatctgcc tcgactacgg cggccgggag gaactggccg ccgccgcccg
    11281 cgcgctggcc gccgaggccg tggcgggaac gatccgcccc gagcagatcg gaatggccga
    11341 ggtggcccgg aatctgtatg tgccggagat gcccgacgtc gacctgctgg tccgcacctg
    11401 cgaacagcgc atcagcaact tcctgccctg gcatctcgcc tacgcggagc tcgtgttcga
    11461 ccctgcgccc tggcccgact tcgacctggc ccggctgcgg gatgccgtgg acagctacgc
    11521 gggccgcgag cgccgtttcg gcggggacgc cgagctgcct gctcaggccg gcaacctgga
    11581 gccggcccgg aacggatgaa cggtccggac cggcgccccg tcagcccttg ggcggggtgt
    11641 acaggccctc tgcggtgacg tgtgccagca ccgtgtccag ggtgaaggag ggtttgccga
    11701 aggtgtgcgt gaaccggtcc agcagttcct gcgtgggccg cagcggcact tcggcgacct
    11761 tgaccctcat cggcttgccc ggcgccacgc tctgtgtcgt cagccggcct tcggccaggc
    11821 cgggccggaa caccggggcg tgccggatct cggcaccgtt ggccacgtac gtgcccgaca
    11881 cctccccgtt gtggaggaag ccctccagat cctccacgtg gaagctggcc cggggggtac
    11941 ggaagacgac cccgccgtcc agccgtccgg caccgctggc ccgctgcagg tcggccaggg
    12001 agggatcgcc ctcactgggc cgcagcggga accggatcgc ggtgccgtgg gcgtttttga
    12061 ccagccgggc cggggccacc ggcttcacca ccacctcttc gcgatccagc accgcctggc
    12121 cctgcggggt ccagcggacc tcgacccagc cgtccgagac cgtgcccagc ctcccggcac
    12181 cggccgcatc cgccactccg gtctcggatg ccgcggcgtc gggcgccgca ctggtgaacg
    12241 aggccagcag gggcagggac aggcccgctc ccaccaccga tcgtcgtttc gcgctcattg
    12301 aaccgtcctc tctcgggccg cagggtcacg gcccacaaag atcaacggac gacccggggc
    12361 ccggcagacg ggcgcgcccg ggaatcactc gaaagcaggg tgcggtgcgc ggccgccaac
    12421 ctggcgcgca gcatcgccga ggccgggccg gggccgcggg cggtgacgaa cgacgacgag
    12481 gagtgcgtga cgatcgcggg cgggcctctc gtcgaggcgg cggagaccac gcggcgcgcg
    12541 ccattgacgg tgatgcgggc ccgctgagcc cgacctgcga tctcgtggtc ctcaccggac
    12601 cttggaggta tggcgagcgc tccggtactc gtgcatccgc cgctcggtac gggcggcgga
    12661 cgcgtcgccg cgcgcggaca gagcctcggc ctcgcccact ccgatgggga cgtggtcgag
    12721 ttcctgcgca gggtggggtt ggaggatgcc gaggggttgc tcgatgatcc atcgtgggtg
    12781 aagtggcggg gtgggcgtgc acaccactat gaggcggcct gactcgtcac tcgtgaggct
    12841 ggcgtcaagc ggccgaatcg cgtgtcggcg ccacgcacct gcgcgcgact gtgttcagtg
    12901 ggtggcgaat ccgcccccca cgtgaggatc acccttgttc actctgcgcc gtgaagccct
    12961 tcttgcctgc tccgccgttc tcctggcagt cccgacctcg atgggcgtcg cctcggctgt
    13021 ccccgaagac gaagcccttg cggcgaccgc caacgatccg caaccccccg ctacggacga
    13081 ggccacggac gaggcagacg accccttcgc gggactgggc gacaaggagt tcatcatcca
    13141 aaggaccctg gacgggaagg gcggggtggg catgacgtcc atcaagctgc gctgcggcga
    13201 cgacccggcg agcagcgagt cactcgatgg gctcggcgcg cacccgtccc ctcagcttgc
    13261 gtgcgatgag atcgcggcgg caggcggtga cctcaacaag ctgcctggtc tccctgatta
    13321 ccagtgcacg gaagaagata aggccccgag tgatgaagag gccttcttca tgggacgtgg
    13381 tgtctggaac gacagcaaga cgagtttcag caagtcattc acgaatgtgt gcgatgagat
    13441 tcgcgagacg ggccatgtca accaggtcgt cgccgcggat ctgaagggcg aacacaaggg
    13501 ctgatccggc ctcgacggcg gcggttaacc gaattcctcg tcgcgcgcac tgtaaccgaa
    13561 ctccaggaga ctgccgtgaa cgataaggcc attcgccttg atgtcgaaga tcgtgaagcc
    13621 attgggaggc ttcatagcat ggggtaccca gaagctcttt gcgttgaggc ctacttcgcg
    13681 tgcgataaaa acgaagacag ggctgcagat tatatcgcgc agaggttggg tgaggaattc
    13741 aacgataatt gaccgaggtg gtggcccggg tgcccacctc tgcgctcatt gcctggcctg
    13801 ggccaatgag cctcttccaa actggcggcg ctgaccgcga gttgagcagt cgtgcacaac
    13861 gacgaagctc ctggtagacg ggttctcgac caagatcacc catgtcccct aggagcttcg
    13921 cgtgcttgtc tacccgtcct cgatcgactt gtccaaccgc accttgcggt tcctggccgg
    13981 acaactgaca gccaaacgtc gggacatcgg gacccggtgg cgacggcttc ccgtggcacg
    14041 gcaggccctg ctcgccctgg cccacctgcg atgtggtgac acatacgccc agctcgcggc
    14101 cggtttcggc atcgggatcg ccaccgtcta ccgctacata cgtgaggcca tcgaggtcct
    14161 ggccgccctc gccctggccc tgaccgaggc gatgaagacc tccggacgaa ggcgttcgtc
    14221 atcctcgacg gcacgctgct gcccatcgac cgtatcgccg ccgacacccc gtactactcc
    14281 gggaaaaata aacgccacgg catgaacgtc caggttctca ccgatccgtt cggccgtctg
    14341 ctgtgggcct caccggcctt gcccggctcg acccacgatc tgaccgccgc ccggcagcac
    14401 gggatcatcg acgccctcgc cgcagcgggc ctcaaatgct gggcggacaa ggcgtatcaa
    14461 ggcgccggca gacccgtccg cgtcccgttc cgtggccgca ggctcaaacg atgggagcgt
    14521 cgccacaacg ccacccacgc caagatccgc tgtgtcggtg agcaggccat ggcctccctc
    14581 aagggctggc ggctcctgcg gaaactccgc tgcagcacca accgcatcac caacatcgtg
    14641 aaggccgtcc tcgtcctcca ccacgcatca acgtgaggtt ggatagagct caatgacggc
    14701 gatgagactc ggttgcggca gatcgtcgat gagcttcgcc gtcacatcgc ccagatggac
    14761 agcccgtact tgcttgacct caggtggatg aacggtgagc cgttcatcca cctcggcggc
    14821 tcttccaatc accgctcatc tcctaacgtt gtcgaactgt ttgagcatgt ggccatggtc
    14881 gcccccggtt cctacggcct cctccacttt gacgatgacg aggaaccgga tcgcgagaac
    14941 gagatacggg tgctgaggct cgttcgaggc acggtcacgc agcacaggga ggcattgctg
    15001 tctccataca tcccgacggt ggaagacccc tttacgggtt gaggcgtcct cgggggatca
    15061 ggctcggagc cagagccgga tcgcggccac cgtgacggtg ccgtggaaga cgtaggcccg
    15121 tttgtcgaag cgagtcgcga cggcacggaa gctcttcagg cggctgatcg tccgctcgac
    15181 ctcgttgcgg cgcttgtacc gctccttgtc gaagccgaca ggtcggccgc ctctgctccc
    15241 acgacgccga cggttggctc tctggtccct cggctcggga atggtgtgct tggtcctgcg
    15301 cctgcgcagg caacggcggt tacggcggga cgaatacgcc ttgtctgcgc tgagtcggcc
    15361 cggggtggtg cgcggccttc cttctccggt gcggcgcacg cggatgcgct cgaggaccgg
    15421 gatcatctgt ggtgcgtcgc cccactggcc gggagtgacc agcagagcga gcggtctgcg
    15481 gccgccgtcg ctcgcgaggt gaatcttgct cgtcagtccg ccccgggacc ttccgagccc
    15541 ctcgtcgggg cggtgctgcc gaggggttga tcttttttcg gtgtccgcgg agccttcctg
    15601 cgggcgccgg cggcgtgctg gtgggcgcgg caggacgtcg agtcgacgcc caccatgctc
    15661 cagtcgatcc ggtcctcggc atcggcttcg gcctggacgg cctggagtat ccgctcccaa
    15721 gtaccgtcgg cggaccagcg tcggtgccgt tcgtagaccg tcttccacct gccgaacctc
    15781 tccggcaggt ctcgccacgg gatccccgtc cgctcacgga acaagatccc gttgatcacc
    15841 cttcggtggc cggcccaccg cccaccgcgc cgcccgccca cgggcagaag aggctccaga
    15901 cggcgccact cctcgttcgt cagatcacca cgacccacga ccaactacac ggccacggac
    15961 atcggaacac tcatgatccg ccagacacgc cttagtcctc gggaccgctc cgtggatcgg
    16021 gcagcgccgt ttgacgcacc ggtaggagag gctcacggcc ctcgaccgca tcacgcgccg
    16081 ttacgcgagg tctgcacccc aagcaacgtg acgctggcca gcctcacgtg cggcactccg
    16141 gtccgcttcg gtgtcggaga tcggcgcttg ccagtcgtgc aggtggacgt cggcgtcgga
    16201 cgtggcggtg acgtttgctg tggcggtgag gtcggcgccg gtgagctggg cgcgggtcat
    16261 gccggtggcg ggcataggtc gaaggtggtc accggcacga gtatctgtcc gtcggcgtac
    16321 gtcgggacgg agacgtgtgt ggtgtcctgg cccacgcgca cgatgcggac ctggatccgc
    16381 tggtaggtgg cggtcacgcg gccgtttcta cgtcactccg gccgagaggg acagcgcctt
    16441 cggcgtgctt gagcgcctgg cgggcggcga ccatggcctc gcccttgatg ccttcggcct
    16501 cgcagcgctt ccaccacggg tggcactgca cctgcgcggt ggccgtgggc agttcgtcga
    16561 ggagacggtc gaactcgttg gcctcggcgg ctgtccggcc gggggaggcg ggccggccgg
    16621 agttttcccg gccccgctcg gtctcctcgg gccagccgtc gtgcggctcg cgggaccagg
    16681 ggagggtggc ctggtgggcg cggagggcgg cgtacagttc ggcggcctgg cgctgggcgg
    16741 cgagcaggcc ggcggggaag gcgtgcggat cgaacgtgtc gggggcgggg gtgctcatgt
    16801 cggtgagcct aatccgagcg gccgacattg cccgggtgtg ctggtcacgg ggcgaggggg
    16861 gtgatgtcgg cgggggtgag gtcggggcgt gtgcggtgca ggcgtgcggg gtgccgccat
    16921 cggccggctg cgtcgcgggc gacgtcgacc tcggccccta cgacgaggtc gggccggatg
    16981 aggtggacgg ggagcacctc gcgcgtcccc catcttgccg aaaaggtccg gcctgcccaa
    17041 gggtgtctcg cttcgggggt ggtgagcagc tcggcgagtg cggtgccggt ggtgcggggc
    17101 agggtggtgg tccggccgat gtaccggagt cggccggcgg tgtcgtagcg gccgaggggc
    17161 agggtgcgcg gcgcggtgac agagccggtg acggcgctca cgatggcgtc ctctgtggcc
    17221 cgcaccttgt acttggccca cgctctggcg cccggcctgt agggggccca gagcggttcc
    17281 aagcagaggc cttccagccc ggccgatgtc caggtcagcc attggcgggc ggtgtccggg
    17341 ttggtggtcg actggcacag cgtgagtggt gcggtcagcc ggtgctcgga gaacagttcc
    17401 tcgagcgccg ttctgcgccg gctgtagggc caggggggag gtcggtgccg ccctggcgca
    17461 tgaggtcgaa gacggaagcg cgcaggttcg cagaatctcg tttccgcaaa aagggaaact
    17521 cgcgcgtggg cccgtgttcc cggcggtatc gcgaacgggt tacgtaactg aagcacatgt
    17581 acgagcggac agaatcagcc aaccaagaga atcaagcctc agtcggcgtg gggagccgag
    17641 gctgtccgcg cttcattcgg cgccagccgg cgtgccatgg aggtgacacc gccgacgagc
    17701 atgtcgaggt tgaagtcgta gtactcatca gggctcacgc agtcggccag tgggtccgca
    17761 caccaaacca ccgtcgggta ccgacggggg gacaaggctg tgagcgacgc tctcttggct
    17821 cgaacggcat cttcgcgcgc ctcctcgtca ctcggatgct cacgtccagg ctccgcggtg
    17881 accagggcaa tgacggcact gagcagatac ccgcccacct ctgcagtgcg gtccgctggc
    17941 aggttgccga gccgcagtag cgaaagggtg cgttcggtaa gggcgaggcc cgccggggac
    18001 gcgaggaccc gcgatgacag cagaggggcg acggcggggt gggggcgcag ggcggccagg
    18061 aacgccgcca agaccgcgct cagttgctga gcccacggcg aggagtcctc gggcgggagt
    18121 tccacgttcg cgaacaggcg ctcggccatg ccgtcgagca gctggtcctt ctccttgaaa
    18181 tgccagtaca gggcggttgg agtgacattg tgctgcttgg ccagcctacg gatggtcacc
    18241 gcctccagcc cctcgacgtc ggcgagtgcg attgcactgt ccgcgatcac ctcccgactc
    18301 aagcgctctt gcccgggggc cgcagttctt ctcatgggcg acatgttgac aactctaccc
    18361 tggacatgtg tcatgtctgt agtacatgaa cgctgtacag gaacaacgta caggaacgtt
    18421 gataagcacg cctttccctg gcggtctggt cctcagaccg cttgcttcag ctcccctccg
    18481 ctccggcccc tggcgcgctg gcggggcttt ccgttgacgg agacctcgat gaccacaacc
    18541 agccgctccg gaacacgctc cgaaaacgtc gcggaacccc acctggaccc cgccctcgtg
    18601 gagcggctga ccgcagcggt gagcgcttcc gcagagccgg cgacgacccg ggcacctttc
    18661 acaggcgcgc ctctcgcgca gattcctcag tcgaccgccg ccgatgtgaa ccaggcgttc
    18721 gccgccgccc gggtcgccca ggtcgaatgg gcacggctca ctccaaagca gcgggccctg
    18781 cccttcgctc ggttccatga cgtgctgctc tcgcggcagg aagagatctt gaacctcctg
    18841 cagtgggaga cgggcaaggc ccggcacgac gccttcgacg aggtgatgga ggccgccacc
    18901 gcctccttgt atgcggcgcg gcaggcaccg aaggtgctgc gcacacggcg tcggcaaggt
    18961 gcattccctg tgttcacccg cgcgttggag tccttccgcc ctaaaggcgt ggtcacggtc
    19021 attacgccat ggaactaccc gttggcactg gggctggacg cgatcccggc gctcctggcg
    19081 ggcaacgcgg tcgtgcacaa gccggacacc cagacggcac tgtcgactct gtggccgcgc
    19141 atggttctgg aggagctggg cctgccgaag ggtctgcggc aggtcgtgct cggtgaaccg
    19201 gcggtgatcg gggatgcgtt gatcgacggc gccgacttcg tcagcttcac cggttcaacc
    19261 cgggcagggc gctccatcgc tgggcgtgcg gcggaacgtt tggtcggatg ctccctggag
    19321 ctcggtggca agaacccgat ggtcgtgctg gacgacgccg acttggatgc caccgtcgag
    19381 tctgcagttc gcggctgcct cggcaactcg gggcagatgt gtgtcgggat cgagcgcatt
    19441 tacgtccacg ccaatgtcta cgacggcttc ctggcgcggt tcgcctccag ggtggagcgc
    19501 atgacgctcc gaccggactt cgacttcgcc accgacatgg ggtcgctcac caattcccgg
    19561 caactggcgc acgtgcaaga gcatgtggag gcagcactcg cagccggcgc gcgggtcgtg
    19621 accgggggtc gagtacgccc cgacctgggt ccgctgttct acgagcccac catcctgacc
    19681 ggagtcccca aaggcacccc cgtgcgcgat gaggagactt tcggaccggt cgtctccgtc
    19741 taccgggtcg actcggacga cgaagccgta ctcgcggcca acgacagccc ctacggcctc
    19801 aacgcggccg tttacagccg aagtgaggca agggcacgca cgctggccgc acgtatccag
    19861 gcgggcacgg tcaacatcaa cgagggttac gcatctgcct atgcctcgca gggcgcgtcc
    19921 atgggcggca tgaagtcctc gggtgtaggc cgtcgtcacg gccccgccgg gctggtgaag
    19981 tacaccgagc cgcagacggt cgccagtcag cgactgctcg gcttcgaccc gcccttcggg
    20041 atgagcaggg cgcgtcaggt cgccctgttc accaccttgc tgcgcatctt gaagatgctg
    20101 cgaatccgct gaccccctag accttttccc cacctaccca aagatcatcg aggagccgtc
    20161 atgaaagttc ttgtcactgc agcaaccgga tacctcgggc gtgcggtcgc ccagcgtctg
    20221 cagagcgccg gccaccacgt ctccgctatg gcgcgctccg aggtcagcct gagggccgtg
    20281 gcggctgccg ggttccggcc cgtgcggggc gacataaccg acccgctgtc tgtgcgtgcc
    20341 gcggtcgctg aggtcgacgc ggtcatcgag actgccgctg ccgataatga gagtgccacc
    20401 gagatcctgc tggaagccgt agcagggact gcgaagcgct acgtgcgcac cagcggcacc
    20461 tcggtgttca ccgaactgtc cggtggtgag tcgagcgata cggtgcatgc cgaggacccg
    20521 gcatttgagc cgattccgcc ggtgcagcac cgcttcagcc tggaccgccg ggtcgtcgct
    20581 gctgctgcaa gcggaacgca caccgtggtg ctgcggcccg gcatgatcta cggaggaggc
    20641 gggagcgagc aactgcctgt actcctgcgt gcggctatgc gcgatcgcgt gagccggtac
    20701 atgggatctg ggctgaaccg ctaccccaac gtgttccttg acgacgtcgc ccaggcttac
    20761 gtgctggcgg tggaatcggc gcctgccggg ggcgaataca acatcgccgc tgatgaggca
    20821 acgatgcggg agatcgctga gggcatcgca caggtgctcg ggctggagcc ggctgtctcg
    20881 gccacgatgg aggagatgat cgaggcgatc ggactgctgt acgcgctggg cctgtccagt
    20941 aatgcccgcg tggacgcttc caagattcgc gctgaactgg gctggacgcc acagggaccc
    21001 tcgctgctcg acgacctggt gcacgggtcc taccagaagg tatgggggca ccgggaggta
    21061 agtctgcaaa ccggggatgt gccgcggtga gcggcgccag gccaatccgg cgcaccacac
    21121 cgctggccgg tgagatcatc gctacggact tcgtcagctg gagcccggcg cttcggcagg
    21181 agttcgtggt caacgcgatg aacgtccagg tcggctccga gctcctgtcg gagactgatg
    21241 aactgaaggt gtggcacatc cacgtgccgc cgggcgggcg gctggccgct caccggcacg
    21301 tgctggatta cttctggacg gccttgaccg atggagtcag catccagcac acggacgacg
    21361 gcaccacccg gagagtctcc taccacgcgg gcgacacgcg gcacttcgcc ttccccggcg
    21421 aggagtacct cctgcatgac ctgtgcaatg acggcccggc cgaattgcgg tttctcacag
    21481 tcgagcacaa gctaacccgt ttccgctgac cagaggagtg acgtggcatg cggaagtcag
    21541 acacctgtcg cttcaagcag gtcagcagga tcgcgagcgt gtgcctcgga attccctag
//
