LOCUS       NZ_KZ195574            21059 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195574
VERSION     NZ_KZ195574.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS113
  ORGANISM  Streptomyces sp. CS113
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8695358)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 78.17x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188365.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:31:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,790
            CDSs (total)                      :: 7,719
            Genes (coding)                    :: 7,614
            CDSs (with protein)               :: 7,614
            Genes (RNA)                       :: 71
            rRNAs                             :: 2, 1 (5S, 16S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 81 of 105
            Pseudo Genes (internal stop)      :: 4 of 105
            Pseudo Genes (multiple problems)  :: 15 of 105
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:56:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3109310
            Orig. end                         :: 3130369
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195574.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..21059
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="21"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21059
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21059
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11059](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11059
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(10..27)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.73"
                     /tool="antismash"
     gene            complement(111..1205)
                     /locus_tag="B9W62_RS13385"
                     /old_locus_tag="B9W62_13420"
     CDS             complement(111..1205)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327064.1"
                     /locus_tag="B9W62_RS13385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13420"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087807394.1"
                     /transl_table=11
                     /translation="MPETTEPILEVRGLVKHYPLTSGILFKKQVGAVKAVDGVDFELAR
                     GETLGIVGESGCGKSTVAKMLVNLEKPTAGEIRYKGEDITRLSGRALKSVRRNIQMVFQ
                     DPYTSLNPRMTVGDIIGEAYDIHPEVAPKGDRRKRVQDLLDVVGLNPEYINRYPHQFSG
                     GQRQRIGIARGLALRPEIIVADEPVSALDVSVQAQVINLMGRLQDEFDLSYIFIAHDLS
                     IVRHISDRVGVMYLGRIVETGRDAEIYDHPTHPYTQALLSAVPVPDPDAREHRERIILA
                     GDVPSPTNIPSGCRFRTRCWKARERCALEVPALAVPAEFRSVSGPAAHDSACHFAEEKQ
                     VVPPEGESEGDGRDEGGGDGSGPG"
     gene            complement(1198..2181)
                     /locus_tag="B9W62_RS13390"
                     /old_locus_tag="B9W62_13425"
     CDS             complement(1198..2181)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669150.1"
                     /locus_tag="B9W62_RS13390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087807395.1"
                     /transl_table=11
                     /translation="MLLEVRDLHVEFRTRDGVAKAVNGVTYGVDAGETLAVLGESGSGK
                     SVTAQTIMGILDVPPGRVTAGEILFEGRDLLKLKEEERRKIRGAEMAMIFQDALSSLNP
                     VLTVGDQLGEMFTVHRGMSRKDARAKAVELMDRVRIPAAKERVRQYPHQFSGGMRQRIM
                     IAMAMALEPKLIIADEPTTALDVTVQAQVMDLLAELQRELHMGLILITHDLGVVADVAD
                     KIAVMYAGRIVETAPVHDIYKAPAHPYTRGLLESIPRLDQKGQELYAIKGLPPNLTRIP
                     PGCAFHPRCPMAQDVCRTDVPPLYDVTESDAERGSACHFWRECLHA"
     gene            complement(2190..3170)
                     /locus_tag="B9W62_RS13395"
                     /old_locus_tag="B9W62_13430"
     CDS             complement(2190..3170)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190436.1"
                     /locus_tag="B9W62_RS13395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13430"
                     /product="ABC transporter permease"
                     /protein_id="WP_179235475.1"
                     /transl_table=11
                     /translation="MPEQEPYEPERAIAGTGMGGTMDLGASEAVTLEQPPGPDGADPRD
                     KPRSLWSDAWHDLRRNPVFIISALVILFLIVISLWPSLIASGSPLKCDLAKAQEGSQSG
                     HPFGFNGQGCDVYTRTVYGARTSVAVGILATLGVAILGSVLGGLAGFFGGGGDAVLSRI
                     TDIFFAIPVVLGGLVLLSVITSNTIWPVIGFIVLLGWPQISRIARGSVITAKQNDYVQA
                     ARALGASNSRLLLRHIAPNAVAPVIVVATIALGTYISLEATLSFLGVGLKPPSVSWGID
                     ISSAAPYVRNAPHALLWPSGALAITVLAFIMLGDAVRDALDPKLR"
     gene            complement(3163..4086)
                     /locus_tag="B9W62_RS13400"
                     /old_locus_tag="B9W62_13435"
     CDS             complement(3163..4086)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550237.1"
                     /locus_tag="B9W62_RS13400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13435"
                     /product="ABC transporter permease"
                     /protein_id="WP_087789635.1"
                     /transl_table=11
                     /translation="MGRYVVRRLLQMIPVFIGATLLIFLMVNVMGDPIAGLCGDRECDP
                     ATAAQLRHEFGLDQPVWQQYATYMGNVFTGDFGTAFNGQPVTELMGTAFPVTIRLTIVA
                     ILFEIVVGIILGVVTGLRRGRPVDTGVLLLTLVVISVPTFVTGLLLQLLLGVKWGWIDP
                     AVSSEAAFGELIVPGLVLASVSLAYVTRLTRTSIAENRRSDYVRTAIAKGLPRHRVITR
                     HLLRNSLIPVVTFIGTDIGALMGGAIVTERIFNIHGVGYQLYQGILRQNTQTVVGFVTV
                     LVLVFLVANLVVDLLYAVLDPRIRYA"
     gene            complement(4100..5734)
                     /locus_tag="B9W62_RS13405"
                     /old_locus_tag="B9W62_13440"
     CDS             complement(4100..5734)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444498.1"
                     /locus_tag="B9W62_RS13405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13440"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_087807396.1"
                     /transl_table=11
                     /translation="MRGATHAKWAACAAAVVLAATACGGGGGDGGSGGGGGGVLSSSWG
                     DPQNPLEPANTNEVQGGKVLDMIFRGLKKYDPETGEAKNMLAEKIDTSDSQNFTVTVKD
                     GWTFSNGEKVTAQSFVDAWNYGASLKNNQRNAYFFAYIDGYDKVHPESGSQSADTLSGL
                     KVTGPRTFTIKLNQKFSSFPDTLGYAAFAPLPKAFFDDHDAWLKKPVGNGPYQVDNYTR
                     GSQMSLRKWDDYPGPDKAQNGGVDLKVYTDNNTAYTDLIAGNLDLVDDVPASQLKNVKN
                     DLGDRYINTPAGIIQTLAFPFYDNDWNKSGSEKVRKGLSMAIDRKQITDTIFQNTRTPA
                     TDWTSPVLGEEGGYKPGLCGDACEYNAEEAKKLVKEGGGLPGGQVKITYNADTGSHKQW
                     VDAVCNSINNALDNDRACAGNPVGTFADFRNQITDRKMSGPFRAGWQMDYPLIQNFLQP
                     LYYTNASSNDGKWSNEEFDGLVDKANGQTDTAEAVKTFQQAEEVVRDNMAAIPLWYQNG
                     SAGYSDRLSNVKLNPFSVPVYNEIKVG"
     gene            5991..6155
                     /locus_tag="B9W62_RS40160"
     CDS             5991..6155
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS40160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_160166082.1"
                     /transl_table=11
                     /translation="MSKMLSRIADKLLPQTSAAAGCAPGCWMERSSSGGQFYEYKCCYN
                     PNCSVRCYV"
     gene            6234..6752
                     /locus_tag="B9W62_RS13410"
                     /old_locus_tag="B9W62_13445"
     CDS             6234..6752
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.5"
                     /locus_tag="B9W62_RS13410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13445"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_087807397.1"
                     /transl_table=11
                     /translation="MAVAFGQLCLATVLFWSGLLKLRDVSAFRRHVATTLPRLGGGLSA
                     ALALAVPAVEVAAAGLLLIRPWAWLGCAAATLLLLAFTGYLIGLMRSRPDASCGCAGAD
                     DTPVSEVHVLRNVLLLTVCVLTWWATVRTGGGPGPVSYAVVVAPAAVFGVALLHLGELV
                     SFFRPPRTT"
     gene            6767..7345
                     /locus_tag="B9W62_RS13415"
                     /old_locus_tag="B9W62_13450"
     CDS             6767..7345
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS13415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B9W62_13450"
                     /product="hypothetical protein"
                     /protein_id="WP_087807398.1"
                     /transl_table=11
                     /translation="MSIALAVLALLVASAACGLSVAVALRVKKLLDPLTQEGALSRRRP
                     DELPAVGTVVPPVPGLLDMDGTEVRLPVPGSQPWILSFQSVGCSGCEQQLPGYAKFLRD
                     AGVDRDRVVSFVVGDPDGAALYRDQLGDLAHVVAGEKQAPTLIGELGVSMFPTYLVVDA
                     EGRVTVASGSSARLAGSVSELSASALARS"
     misc_feature    7350..7364
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.98"
                     /tool="antismash"
     gene            7351..9210
                     /locus_tag="B9W62_RS13420"
                     /old_locus_tag="B9W62_13455"
     CDS             7351..9210
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963274.1"
                     /locus_tag="B9W62_RS13420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13455"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087807399.1"
                     /transl_table=11
                     /translation="MFRQGLVPVRGVLSLAREAAPFQLAAYAALDLLSGAFPVAAGWLT
                     KLALDELGAQAPVNTLVALAVGLALVGVVQAVVPHVSGYLQAEVERATGTLAQGRLFTA
                     VGRFVGIGPFEDPRFLDKLRLAKQSGKSAPGQVVAGMLGTVRAGVTIVGFLSSLLVLAP
                     LMALFVLVFAVPVLVAEIVLSRRRADMIWRISPRERREFFFDQLLSNVEAAKEVRLFGI
                     GGFLLGRMQTERLASNAARRGMDRRELSTQSLLALFAALVSGTGLVWAIHSALSGGLTL
                     GDVAIFIAAVAGVQSSVGQLSAGAAQAHQALVLFGHYQDVVGTEPDLPRAAAPLPAPAL
                     AHGLELRDVWFRYGPDQPWILRGVDLFIPQGRSTALVGLNGAGKSTLVKLLCRFYDPTR
                     GAILWDGVDLREFDPEDLRRRTSAVFQDFMHYDLTARENIALGDLDALASSSRVAEAAR
                     NAGIDRTLEGLPRGYDTLVTRTFFPGEEQDDATTGVLLSGGQMQRLALARALVREQRDF
                     LILDEPTSGLDAEAEHELHARLSEFHRGRTSLLISHRLGSVREADLIVVLSEGRITERG
                     DHAALMARDGSYARLFGLQAAGYTGESAHLPEHGPAAVEGAVS"
     gene            9207..9656
                     /gene="lepB"
                     /locus_tag="B9W62_RS13425"
                     /old_locus_tag="B9W62_13460"
     CDS             9207..9656
                     /EC_number="3.4.21.89"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006465 - signal peptide processing
                     [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="lepB"
                     /inference="COORDINATES: protein motif:HMM:TIGR02227.1"
                     /locus_tag="B9W62_RS13425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13460"
                     /product="signal peptidase I"
                     /protein_id="WP_218781987.1"
                     /transl_table=11
                     /translation="MRWAVVGGCAGLVVAGTALLRRRLVSVTVTGHSMLPAYRPGDRVL
                     VRRGVVPRRGGVVVVELPDTEHRSWISAPAGLGSPGAPVTERQWLLKRVSAVAGDPCGS
                     RDAAAGRVPPGHLLLLGDNASVSFDSRQMGPFPVERVLGAVWRRL"
     gene            9769..9909
                     /locus_tag="B9W62_RS40165"
     CDS             9769..9909
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W62_RS40165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_160166081.1"
                     /transl_table=11
                     /translation="MQDSTRGTQDDERALPVVTEPEGQTELIEIRLLDKIETIDSKAVA
                     R"
     gene            10001..11059
                     /locus_tag="B9W62_RS13430"
                     /old_locus_tag="B9W62_13465"
     CDS             10001..11059
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384255.1"
                     /locus_tag="B9W62_RS13430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13465"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_256976317.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 3.8e-12,
                     bitscore: 45.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.5e-39, bitscore: 134.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKREHIPHRFDDGTVRLGGEVYGIAAEITDPHGWAWDALTRMDGT
                     APRRDIETALAERHPRLGADGARRLVRELIGTGYVEDAATGRPEGFTDGELERYSRNHD
                     YFRRVDLRPGSDPWEAQRRIGRARVTVLGVGGAGSHAAWALTAVGVGSLHLVDPDRVEV
                     SNLTRQALYTEADVGRAKARVAAERLAAVNSAATFTYDVRRVDTQDALRELVAGCDVFV
                     LGADEPRNDVINTMTSRVCAALRIPWVTAGYNGPLVTVGVYGPEGPCFACVGAGEEARL
                     KPGWHPDLGGTGALAPAAGISGQLIANEVVSLITGTGSTAPGYVRGLNLIAPDHLVHVR
                     HPARPECPLCNP"
     aSDomain        10004..10255
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B9W62_RS13430_Pantocin_Microcin_RRE.1
                     "
                     /evalue="1.40E-14"
                     /identifier="RREFam017.1"
                     /label="B9W62_RS13430"
                     /locus_tag="B9W62_RS13430"
                     /protein_end="85"
                     /protein_start="1"
                     /score="45.0"
                     /tool="antismash"
                     /translation="KREHIPHRFDDGTVRLGGEVYGIAAEITDPHGWAWDALTRMDGTA
                     PRRDIETALAERHPRLGADGARRLVRELIGTGYVEDAAT"
     gene            11047..12267
                     /locus_tag="B9W62_RS13435"
                     /old_locus_tag="B9W62_13470"
     CDS             11047..12267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444473.1"
                     /locus_tag="B9W62_RS13435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13470"
                     /product="hypothetical protein"
                     /protein_id="WP_087807401.1"
                     /transl_table=11
                     /translation="MQPLTGGPEGLRVSFHGLEFRPDRDEWIVGRQGTDEIVALPAIGM
                     DAVRLLSAGRTVEETRSSLRTATGRDVDVRAFVERLASAGLVASIGERRFPVAPAAVSF
                     PRVRPHHVRLLLNPVLHAVLLLVPVAGLAVALTRPGTFPSWDSFLWTEYGTFTVLVQCV
                     IGWCLIALHEAAHLLTARAAGVPGRIRLGTRLQFLVAQTEVSGIWLKGRRERLTVYLSG
                     IVLDAVIWGGCLLARGWGADGVLLPVIVATLFLALANQCLVFMRTDLYFVVQDLTGCRN
                     LFTDTARCLRHVAALPFGRRAPHPLRSLPSRERRFVQAYAVAVGVGSVVCLAIGFRVLT
                     EVTWPLLRRSLVHLVDGSGWWLRLDALTTVLVLCGMQALWARLWWRRHGERVKRVRLAA
                     RAWRRGY"
     gene            12315..15689
                     /locus_tag="B9W62_RS13440"
                     /old_locus_tag="B9W62_13475"
     CDS             12315..15689
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444472.1"
                     /locus_tag="B9W62_RS13440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13475"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_087811892.1"
                     /transl_table=11
                     /translation="MHNRSPRFRLLGPLEIRVDETAVLLTGRQRALCAVLLLHADRVVS
                     VDRLARGLWDERMPSASAARIRALVSEVRQAFGVDGAALLATQKPGYVLRAAPAEVDAF
                     LFEALIRDGLRALAHEEWAQAYRYHDDALALWRGDPLPDLPTMEAERRRLTELRIAAEE
                     GRAEAELELGRPRSAVADLVRLTSEHPLRERPHALLMRALALDGRSPDALAVYTGLRNR
                     MVRELGVDPSDELTGLHRKLLAGGAAPRTAAPAPAEPARSRRVPRQLPRAPHRFVGRNA
                     ELRLLDACRRDGGAPAVLVGPAGAGKTALALHWAHRIADDYPDGQLFLDMRGFDNAEPM
                     SLEEALPLLLQGLGCAPHDIPLGLDAQTALYRTLLADRRVLVLLDDVADASTVRRLLPA
                     ASGSLALVTSRRKLNGLVLDGAHRVTCDVLSREEALELFGASIGAEAVAADPAAAAHLV
                     ELCDHLPLALCVAGSWIGAGSGSVRAYVTSLAERGRLARLHVEGEESVAVRAALDLSYG
                     TLPDEARWAFRSLGLLPGTGRSVAAAAAAAGLDETRTADLLRLAQRVHLLRDDAYGRMT
                     WHDLVHEYAAERVVAEDAEAERARAVDRLLDHYLQSVSRVAATCRLYCPQPLPEPVGGS
                     APRTFRTPEEAFAWFDEEWEDIAAAIAYAAEHGPARFAWQIVDALQDLFHHRRPLADWL
                     RLAALAGRAAERGGDRRGQAVVHLSSGHARWRSGDFRGALGAYESAQAAARDAGWLSGE
                     ARSAQGRGVTLKLLGEPSEALPFYDRALTLYRSLGMTEPEKIMLTNTASLKLALGRLAE
                     AEEAVTAALALHDGRQEHLHSMTLVNHALVQQKQARFREAAATLWQGLEVSRGAASLYA
                     EAVMLETLGRVRDDAGQDARALLAYEDALGLAQRVGNRNCQVDSLVGLAAVKLRTGRTP
                     EAAAHLDEARTVAEETGHRTGLIEILLVRGALHCAQERYREAAAVLETAGRLAVNGSPL
                     TLPRIRTLGAVALRETGETGAALEAAREAVGQARNSGQRLVLARAATALASVCEAVGDT
                     RAAAGHRDEARVLFDEIGVPSSHRTATGHPGAGTPPDRGPRARGARPCLPDDTEERFAR
                     YLADHFDDLAGQQVPRP"
     gene            complement(15686..16477)
                     /locus_tag="B9W62_RS13445"
                     /old_locus_tag="B9W62_13480"
     CDS             complement(15686..16477)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444494.1"
                     /locus_tag="B9W62_RS13445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13480"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_087807402.1"
                     /transl_table=11
                     /translation="MNVQILGCTELRAADGQNIAVSPTVSRLLATLAWSANSFVTDEDT
                     IGRVWESRVPVRPRDALYTLVTRLRKALRAVGAPGAPCDVVRRPGGYTMVAAEEAVDVL
                     GFRALVRQARNAQCRGAEEAALQFYEQALALCHGRPLSDVRTAWADAARITFERELRTV
                     RTNSAELALGLGRCGDYVPLLHELAAAHPLDERIASLLMLALYRSGRQDEALRCFRSTR
                     ARLVAELGVEPGSRLRMLHERILRRDEVVQGGRPVWAAMAS"
     misc_feature    complement(16538..16549)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    16864..16879
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.93"
                     /tool="antismash"
     misc_feature    complement(16890..16903)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.14"
                     /tool="antismash"
     gene            16969..17997
                     /locus_tag="B9W62_RS13450"
                     /old_locus_tag="B9W62_13485"
     CDS             16969..17997
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444470.1"
                     /locus_tag="B9W62_RS13450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13485"
                     /product="ABC transporter permease"
                     /protein_id="WP_256976318.1"
                     /transl_table=11
                     /translation="MTPPTPSAAAPLEVTDETVDKSPTPATPKGSESRSPGRLAWKRFK
                     RDRTGVISACIVIFFFVIALAAPLIAKLYGKDPYTTYASQRPELLDAFSYPAGPNGGMS
                     SEFWFGIEPQLGRDVFTFLLYGIRTSLGLALAATVVTAVLGVVIGTTAGYLGGKTDYFV
                     GRIIDILLSFPSTLFFIAFMPVIYGLFVAPDENIPTSLRAISLIIVLSGFGWASLARLL
                     RGQVLGLREREFVEAAKVTGASPWRIVFKELLPNLWTPIIIQTTLMLPMFVTAEAGLAF
                     LGVGMIDPTPDWGVMIQRGAQFYTEDITFMLFPGLSMVIFVLAFNLLGDSVRDALDPKT
                     KR"
     gene            18076..19836
                     /locus_tag="B9W62_RS13455"
                     /old_locus_tag="B9W62_13490"
     CDS             18076..19836
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444469.1"
                     /locus_tag="B9W62_RS13455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13490"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_087807404.1"
                     /transl_table=11
                     /translation="MAFSRRNFLIATGVVAASSSVLTACGGSDNKGGGKSDAPKVSGSK
                     TVEILVGTKADSTGPAPEVKGAVKGGIIHSLDQFDMDHMDPAQIYVSTEGAITVPIMRG
                     LTGYKIDDKGGCTLVGDVATDAGTMKDGGKTWSFTIKDGVKWEDGSDLSMDDVRHTYER
                     LFADFITEGPRYVQQFLVGGDKYKGPYEGKHLDSIEIDGKTVTFRLNEPRADFNFTLAM
                     RGFSLVPKAKDTKQKYDSRPFSCGPYKISERSVGKSLTYVRNEHWDPKTDAIRNAYPDE
                     YRFRFGYQPLAATDRFIADSGEDQQAMAIFNEVAPERIAKVLTDPNLKKRVLTAVDTVT
                     YYWPINTTRIKDVKVRQAINWAWPHQQLQTIRGGASTSELATTILSPVTPGHEEFDLYG
                     VDKKPGGDPEKAKALLKEAGKVGQKLVIAYQTSDNALKQAVAIKNALEAAGFEVVNKQL
                     DKSTFYTQIGKIDNGYDLFAAGWSPDWPNGYSVFYPCWSGENIGDGRSNYAQLDDPSVN
                     KAINAASKIADAEAANKAWGAIDRQIMELAAVVPDYHSIRNWMYGSKIGNVVFDYGNTC
                     IALCKLYVKK"
     gene            19939..20919
                     /locus_tag="B9W62_RS13460"
                     /old_locus_tag="B9W62_13495"
     CDS             19939..20919
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000914.1"
                     /locus_tag="B9W62_RS13460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W62_13495"
                     /product="ABC transporter permease"
                     /protein_id="WP_087807405.1"
                     /transl_table=11
                     /translation="MFRFLVRRVFGALVILLIISAITFWLFYAVPRDPAMMSCGKNCTP
                     ENLEQIRKNLGIDESIVMQYWHWLTGIFAGRDYAGYGRCDAPCLGYSFANSEPVYGTIM
                     DRLPTTLSLAFGAAIFFLIIGIGAGMLAASKQGKFLDKFASSVSLLGSSLQIYFVGYIA
                     MFFLVGELGILSQPSYTPLTDDPVAWMSGLLLPWLVLSIIFTANYTRMTRSQMVEQLSE
                     DYVRTARAKGLSRRNVFFRFAWRGAMGPIVTIFGVDLGVLIGGAIITETTFSIQGIGRL
                     AIESVFKSDLPMLLGVTVLAAGAIVMFNIVVDAVYALIDPRIRLA"
ORIGIN
        1 ccaacgcctt tgacacgcgg gtaacttcgg cgaagcggtc ccgacacacg ggcccgcgac
       61 gctgatcggc gtacggccgt gcgggtgccg taagcgggcc ggggaccatg tcaccccggc
      121 ccgctgccgt cgccgccgcc ctcgtccctg ccgtcgccct cgctctcccc ctcgggcggc
      181 accacctgct tctcctccgc gaagtggcag gcggagtcat gcgccgcggg cccggagacc
      241 gagcggaact cggcggggac ggccagggcc ggcacctcca gcgcgcaccg ctcgcgcgcc
      301 ttccagcagc gggtgcggaa gcggcagccg gaggggatgt tcgtcgggga cgggacgtcg
      361 ccggccagga tgatccgctc gcggtgctcc cgggcatccg ggtcgggcac cggcacggcg
      421 gacagcagcg cctgggtgta ggggtgggtc gggtggtcgt agatctccgc gtcccggccc
      481 gtctccacga tgcggcccag gtacatcacg ccgacccggt cggagatgtg ccggacgatc
      541 gacaggtcgt gggcgatgaa gatgtaggac aggtcgaact cgtcctggag gcggcccatc
      601 aggttgatca cctgggcctg cacggacacg tcgagggcgg agaccggttc gtcggcgacg
      661 atgatctccg ggcgcagcgc caggccccgc gcgatgccga tgcgctggcg ctggccgccg
      721 gagaactggt gggggtagcg gttgatgtac tccgggttca ggccgaccac gtccagcagg
      781 tcctggaccc gcttgcgccg gtcgcccttc ggggccacct ccgggtggat gtcgtaggcc
      841 tcgccgatga tgtcgccgac ggtcatacgg gggttgaggg aggtgtaggg gtcctggaag
      901 accatctgga tgttccggcg cacggacttc agggcccggc ccgacagccg ggtgatgtcc
      961 tcgcccttgt agcggatctc ccccgccgtc ggcttctcca ggttgaccag catcttggcg
     1021 accgtggact tgccgcagcc ggactcgccg acgatgccga gggtttcgcc gcgggccagt
     1081 tcgaagtcca cgccgtcgac ggccttgacc gcgccgacct gcttcttgaa gaggatgccg
     1141 gaggtcagcg ggtagtgctt gaccaggccg cggacttcga ggatcggctc ggtggtctca
     1201 ggcatgcagg cactccctcc agaagtggca ggcgctgccc cgctcggcgt cggactcggt
     1261 gacgtcgtac agcggcggta cgtcggtgcg gcagacgtcc tgggccatcg ggcagcgggg
     1321 gtggaaggcg cagccgggcg ggatgcgggt gaggttgggc ggcaggccct tgatggcgta
     1381 cagctcctgg cccttctggt ccaggcgcgg gatcgactcc agcaggccgc gggtgtacgg
     1441 gtgggccggg gccttgtaga tgtcgtggac cggggccgtc tccacgatcc ggcccgcgta
     1501 catgaccgcg atcttgtcgg cgacgtcggc gaccacgccg aggtcgtggg tgatgaggat
     1561 cagccccatg tgcagctcgc gctggagttc cgcgagcagg tccatgacct gggcctggac
     1621 ggtgacgtcc agggcggtgg tcggctcgtc ggcgatgatc agcttgggtt ccagggccat
     1681 cgccatcgcg atcatgatgc gctggcgcat gccgccggag aactggtgcg ggtactgccg
     1741 cacccgctcc ttggcggccg ggatgcggac ccggtccatc agctcgacgg ccttggcgcg
     1801 ggcgtccttg cgggacatgc cgcggtgcac ggtgaacatc tcgccgagct ggtcgcccac
     1861 ggtcaggacg ggattgagcg aggacagcgc gtcctggaag atcatcgcca tctcggcacc
     1921 gcggatcttg cggcgctcct cctccttgag cttcagcagg tcccggccct cgaagaggat
     1981 ctctccggcg gtgacccggc cgggcgggac gtcgaggatg cccatgatcg tctgagcggt
     2041 gacggacttg ccggagccgg actcgccgag caccgcgagg gtctcgcccg cgtccacgcc
     2101 gtaggtgacc ccgttgacgg ccttggcgac accgtcgcgg gtgcggaact ccacgtgcag
     2161 gtcgcgcact tcgagcagca tgcggtcgct cacctcagct tcgggtcgag ggcgtcgcgc
     2221 accgcgtcgc cgagcatgat gaacgcgagg acggtgatgg cgagcgcccc cgacggccac
     2281 agcagcgcgt gcggggcgtt gcgcacgtag ggggcggcgg aggagatgtc gatgccccag
     2341 gagacgctgg gcggcttcag gccgacgccg aggaaggaca gggtcgcctc cagggagatg
     2401 taggtgccga gcgcgatggt cgccacgacg atgaccgggg cgacggcgtt gggcgcgatg
     2461 tgccgcagca ggagccggga gttggaggcg cccagcgccc gggccgcctg tacgtagtcg
     2521 ttctgcttgg cggtgatgac ggagccgcgg gcgatgcggg agatctgcgg ccagccgagc
     2581 agcacgatga agccgatgac cggccagatg gtgttgctgg tgatgacgga gagcaggacg
     2641 agaccgccca ggacgaccgg gatggcgaag aagatgtcgg tgatccggga caggaccgcg
     2701 tccccgccgc cgccgaagaa cccggcgagg ccgccgagga cgctgccgag gatcgcgacg
     2761 ccgagggtgg ccaggatgcc gaccgcgacc gaggtgcggg cgccgtagac ggtgcgggtg
     2821 tagacgtcgc agccctggcc gttgaagccg aagggatggc cggactggga gccctcctgc
     2881 gccttggcca ggtcgcactt gagggggctg ccggaggcga tcagggacgg ccacagggag
     2941 atgacgatca ggaagaggat caccagcgcc gagatgatga agacggggtt gcggcgcagg
     3001 tcgtgccagg cgtcggacca caggctgcgc ggcttgtccc gcgggtcggc cccgtccggg
     3061 cccggcggct gctccagcgt gaccgcctcg ctcgcgccga ggtccatcgt gccgcccatg
     3121 ccggtgccgg cgatggcgcg ttcgggctcg tagggctcct gttcaggcat agcggatcct
     3181 cgggtcgagt acggcgtaca ggaggtcgac gacgaggttg gcgacgagga agacgaggac
     3241 caggacggtg acgaagccga cgacggtctg ggtgttctgg cgcaggatgc cctggtagag
     3301 ctggtagccg acgccgtgga tgttgaagat ccgctcggtg acgatggcgc cgcccatgag
     3361 cgccccgatg tcggtgccga tgaaggtgac gacggggatc agggagttgc gcagcaggtg
     3421 ccgggtgatg acccggtggc ggggcagccc cttggcgatg gcggtgcgga cgtagtcgga
     3481 gcgccggttc tcggcgatgg aggtgcgggt cagccgggtg acgtaggcca gcgacaccga
     3541 ggcgaggacc aggccgggga cgatcagctc gccgaaggcc gcctcggagg agacggccgg
     3601 gtcgatccag ccccacttga cgccgagcag cagctggagc agcaggccgg tgacgaaggt
     3661 ggggaccgag atgacgacga gggtcagcag cagcaccccg gtgtcgacgg ggcggccgcg
     3721 gcgcaggccg gtgacgacgc ccaggatgat gccgacgacg atctcgaaga ggatcgcgac
     3781 gatggtgagc cggatggtga ccgggaacgc cgtccccatc agctcggtga ccggctggcc
     3841 gttgaaggcg gtgccgaagt cgccggtgaa gacgttgccc atgtaggtgg cgtactgctg
     3901 ccacacgggc tggtcgaggc cgaactcgtg ccgcagctgc gcggccgtcg ccgggtcgca
     3961 ctcccggtcg ccgcacagac ccgcgatggg gtcgcccatc acgttgacca tcaggaagat
     4021 cagcagcgtg gccccgatga agaccgggat catctggagc agccgccgga cgacgtagcg
     4081 tcccatggag cccgccccct cagccgacct tgatctcgtt gtagaccggg acgctgaacg
     4141 ggttgagctt cacgttggag agccggtccg agtagccggc gctgccgttc tggtaccaga
     4201 gcgggatggc ggccatgttg tcgcggacga cctcctcggc ctgctggaag gtcttgacgg
     4261 cctcggcggt gtcggtctgg ccgttggcct tgtcgacgag cccgtcgaac tcctcgttgg
     4321 accacttgcc gtcgttggag gaggcgttgg tgtagtagag cggctggagg aagttctgga
     4381 tgagcgggta gtccatctgc cagccggcgc ggaaggggcc gctcatcttc ctgtcggtga
     4441 tctggttgcg gaagtcggcg aaggtgccga ccgggttccc ggcgcaggcg cggtcgttgt
     4501 ccagggcgtt gttgatggag ttgcagaccg cgtcgaccca ctgcttgtgg gagccggtgt
     4561 cggcgttgta cgtgatcttg acctggccgc cggggagtcc gccgccctcc ttgaccagct
     4621 tcttggcctc ctcggcgttg tactcgcagg cgtccccgca caggcccggc ttgtagccgc
     4681 cctcctcgcc gaggaccggt gaggtccagt cggtggccgg ggtccgggtg ttctggaaga
     4741 tcgtgtcggt gatctgcttg cggtcgatcg ccatggacag gcccttgcgg accttctccg
     4801 agccggactt gttccagtcg ttgtcgtaga acgggaaggc gagggtctgg atgatgccgg
     4861 ccggggtgtt gatgtaccgg tcgccgaggt cgttcttgac gttcttgagc tgggaggccg
     4921 ggacgtcgtc gacgaggtcg aggttgcccg cgatcaggtc ggtgtaggcg gtgttgttgt
     4981 cggtgtagac cttgaggtcc acgccgccgt tctgcgcctt gtccgggccg gggtagtcgt
     5041 cccacttgcg cagggacatc tgggaaccgc gggtgtagtt gtcgacctgg taggggccgt
     5101 tgccgaccgg cttcttcagc caggcgtcgt ggtcgtcgaa gaacgccttg ggcagcggcg
     5161 cgaaggcggc gtagccgagg gtgtcgggga agctggagaa cttctggttg agcttgatgg
     5221 tgaaggtgcg cgggccggtc accttcagcc cggagagcgt gtcggcgctc tgcgagccgc
     5281 tttcggggtg caccttgtcg tagccgtcga tgtacgcgaa gaagtacgcg ttgcgctggt
     5341 tgttcttcag gctcgcgccg tagttccagg cgtccacgaa ggactgcgcg gtgaccttct
     5401 cgccgttgct gaaggtccag ccgtccttga cggtgacggt gaagttctgc gagtccgagg
     5461 tgtcgatctt ctcggcgagc atgttcttgg cctcgccggt ctcggggtcg tacttcttca
     5521 gcccccggaa gatcatgtcg aggaccttgc cgccctgcac ctcgttggtg ttggccggct
     5581 ccagcgggtt ctgggggtcg ccccaggagg agctgagcac gccgccaccg cccccgccgc
     5641 tgccgccgtc cccgcctccg ccgccgcagg ccgtcgccgc gaggactacc gccgccgcgc
     5701 aagcggccca tttggcgtgc gtggctccgc gcatggagtg cctcctcgtg ccctgactcg
     5761 tccgttgccc catttcagtc aatatcggcg gattgcaggc actccgcacg ttcagtccca
     5821 ccatccgggg tgccccgcgg cccgggggcg gccgcccacc ggctccgcca cccgctcacg
     5881 gcgccggaaa ggccgctgaa agacgacgga aagtccgccg gtggagcctg gggaccgagg
     5941 ccgggcgccc gcctgacgcc ccgacggaga aacacgacaa ggagaactcc atgtccaaga
     6001 tgctgagccg tatcgccgac aagctgctgc cccagacgtc cgccgccgcc ggctgcgcgc
     6061 cgggctgctg gatggagcgc agcagctcgg gtggccagtt ctacgagtac aagtgctgct
     6121 acaacccgaa ctgctcggtg cgctgctacg tctgagaccc gtggccgccg tgcccgagca
     6181 ggtgcacggc ggccatcggc cacccgatcc acatctagcg ggaatggaca gacatggcag
     6241 tagcattcgg ccagttgtgt ctggccaccg tgctcttctg gtcgggcctg ctcaagctcc
     6301 gggacgtctc cgcctttcgc cggcacgtcg ccaccaccct gccgcggctc gggggcggcc
     6361 tctcggcggc cctggccctc gcggtccccg ccgtcgaggt ggccgccgcg ggactgctgc
     6421 tgatccgccc gtgggcctgg ctcgggtgtg ccgcggccac gttgctgctg ctggccttca
     6481 cgggatacct gatcggcctg atgcggtcgc gcccggacgc gtcctgcggc tgcgccggag
     6541 cggacgacac gcccgtctcc gaagtgcacg tcctgcgcaa cgtcctgctc ctgaccgtct
     6601 gcgtcctcac ctggtgggcc accgtgcgca ccggcggcgg tcccggcccg gtctcctacg
     6661 ccgtggtcgt ggcacccgcc gcggtcttcg gcgtcgccct gctccacctc ggggaactgg
     6721 tctccttctt ccgccccccg cgcaccacct gagaactgga gtccctatga gcatcgcgct
     6781 cgccgtcctc gccctgctgg tcgcttccgc cgcgtgcggt ctctccgtgg ccgtcgcgct
     6841 gcgcgtcaag aagctcctcg atccgctgac ccaggaggga gcgctgagcc gccgccgccc
     6901 ggacgagcta cccgccgtgg gcaccgtcgt cccgccggtg cccggactcc tcgacatgga
     6961 cgggaccgag gtgcggctgc ccgttcccgg ctcgcagccg tggatcctct ccttccagtc
     7021 ggtcgggtgc agcggctgtg agcagcagct gccgggatac gcgaagttcc tgcgcgacgc
     7081 gggtgtcgac cgggaccgcg tcgtctcctt cgtcgtcggg gacccggacg gcgccgccct
     7141 ctaccgggac cagctcggcg acctggccca cgtcgtcgcc ggcgagaagc aggcacccac
     7201 tctgatcggc gagttggggg tgtcgatgtt ccccacgtac ctcgtggtgg acgcagaggg
     7261 cagggtgacg gtggcgtccg gcagttcggc ccggctcgcc ggcagcgtct ccgagctgtc
     7321 cgcgtcggcc ctcgcccgga gttagcgctc atgttcagac aagggctcgt cccggtccgg
     7381 ggcgttctct ccctcgcccg cgaggccgcc ccgttccagc tggccgccta tgccgcgctc
     7441 gacctgctca gcggggcctt cccggtcgcc gccggctggc tcaccaagct cgccctcgac
     7501 gagctgggcg cccaggcgcc ggtgaacacg ctggtggcgc tggccgtcgg gctggccctc
     7561 gtcggcgtcg tgcaggccgt cgtcccgcac gtctccggct atctgcaggc ggaggtcgag
     7621 cgggccaccg gaaccctggc gcaggggcgg ctgttcaccg cggtgggccg gttcgtcgga
     7681 atcgggccct tcgaggaccc gcgcttcctg gacaagctgc gcctggccaa gcagtcgggc
     7741 aagagcgcgc ccggccaggt ggtggcaggg atgctgggaa ccgtgcgcgc gggcgtcacc
     7801 atcgtgggct tcctcagttc cctcctggtc ctcgcgccgc tgatggccct gttcgtcctg
     7861 gtcttcgcgg tgcccgtgct ggtcgccgag atcgtgctgt cccgtcgcag ggcggacatg
     7921 atctggcgca tcagcccgcg ggaacgccgc gaattcttct tcgaccagtt gctctccaac
     7981 gtcgaggccg ccaaggaagt acggctgttc ggcatcggcg gcttcctgct gggccggatg
     8041 cagacggagc ggctcgcctc gaacgccgcg cggcgcggga tggaccgccg tgagctctcg
     8101 acccagtccc tgctggcgct gttcgcggcg ctggtgtccg ggaccggcct ggtctgggcc
     8161 atccacagcg cgctgtccgg cgggctcacg ctgggagacg tcgcgatctt catcgccgcc
     8221 gtcgccgggg tgcagagctc cgtcggccag ctgtcggccg gcgcggccca ggcccaccag
     8281 gcgctggtgc tgttcggtca ctaccaggac gtcgtcggca cggaacccga cctgccgcgt
     8341 gccgccgctc cgctgcccgc ccccgccctg gcacacggac tcgaactgcg cgacgtctgg
     8401 ttccgctacg gcccggacca gccgtggata ctccgggggg tcgacctgtt catcccccag
     8461 ggacggagca ccgccctcgt cggtctcaac ggagcgggca agtccacgct ggtcaagctc
     8521 ctgtgccggt tctacgaccc gacgcgcggc gcgatcctct gggacggcgt cgacctccgc
     8581 gagttcgacc cggaggacct gcgccggcgg acgagcgcgg tcttccagga cttcatgcac
     8641 tacgacctca ccgcacggga gaacatcgcg ctcggcgacc tggacgcgct ggcttcctcc
     8701 tcgcgcgtcg ccgaggcggc ccgcaacgcg ggcatcgacc ggacgctgga gggcctcccc
     8761 cgcggatacg acaccctggt cacccggacc ttcttcccgg gcgaggagca ggacgacgcg
     8821 accaccggcg tcctgctgtc cgggggccag atgcagcggc tggccctggc ccgtgccctg
     8881 gtgcgcgagc agcgcgactt cctgatcctg gacgagccca cctccggtct cgacgccgag
     8941 gccgagcacg aactgcacgc gcggctgagc gagttccacc gcgggcggac gagtctgctc
     9001 atctcccacc ggctgggttc cgtacgggag gccgacctca tcgtcgtcct ctccgaggga
     9061 cggatcacgg agagaggtga ccacgccgcc ctgatggccc gtgacggctc gtacgcccgg
     9121 ctcttcgggc tccaggccgc cgggtacacg ggggaatccg cgcacctgcc ggaacatggg
     9181 ccggccgccg tggaaggagc ggtgtcgtga ggtgggccgt ggtgggcggg tgcgcgggac
     9241 tcgtcgtcgc ggggacggca ctgctgcgcc ggcgcctcgt ctcggtcacc gtcacgggac
     9301 acagcatgct gccggcgtac cggcccggcg accgggtcct ggtgcggcgt ggtgtcgtcc
     9361 cgcgccgcgg cggcgtggtc gtcgtggagc tcccggacac ggagcaccgc agctggattt
     9421 ccgcgccggc cggactgggc agtcccggag cgccggtgac cgagcgtcag tggctgctca
     9481 aacgggtctc cgccgtggcc ggcgatccgt gcggcagccg ggacgcggcg gccggccggg
     9541 taccgccggg ccatctgctg ctgctcgggg acaacgcgtc cgtcagtttc gactcgcgcc
     9601 agatggggcc ctttcccgtg gaacgggttc tcggcgcggt gtggcggcgg ctgtgacctt
     9661 cggggctgct ccggggctgc tccggggcta cctcggggct ccgttcggag cttcgtcgga
     9721 ggatcacggc ggaccaggga aacgcacatc caggagagag gaagacacat gcaggacagc
     9781 acgcgcggca cgcaggacga cgagagggcg ctccccgtgg tgacggagcc ggaggggcag
     9841 accgagctga tcgagatccg cctgctcgac aagatcgaga ccatcgacag caaggcagtc
     9901 gccaggtagt cgccgggtag ccgccgggca atcaccggcc cacggcggac cgttgcgtcg
     9961 cagaagcact ccgggaaggc tggttgtgag acgtccacga gtgaaacggg aacacatccc
    10021 gcaccggttc gacgacggaa cggtccgcct cggcggcgag gtctacggaa tcgcggcgga
    10081 gatcaccgac ccccacggct gggcatggga cgccctgacc cggatggacg ggacggctcc
    10141 acgccgggac atcgagacgg cgctggccga gcggcacccc cgcctcggtg ccgacggagc
    10201 ccggcggctg gtgcgggagc tgatcggcac cgggtacgtg gaagacgcgg ccaccggccg
    10261 tcccgagggg ttcacggacg gcgagctcga gcgctacagc cgcaaccacg actacttccg
    10321 gcgcgtcgat ctgcgtccgg ggagcgaccc ctgggaggcc cagcggcgca tcggacgcgc
    10381 ccgggtgacc gtgctgggcg tcggaggcgc cggcagccac gccgcctggg cgctgaccgc
    10441 ggtcggcgtc gggtccctgc atctcgtgga tcccgaccgt gtcgaggtgt ccaacctgac
    10501 ccggcaggcg ctgtacaccg aggcggacgt gggccgggcc aaggcacggg tggccgccga
    10561 acgcctcgcc gcggtcaact ccgcggcgac gttcacctac gacgtgcggc gggtggacac
    10621 gcaggacgcg ctgcgtgaac tcgtcgccgg ctgcgacgtc ttcgtactgg gtgcggacga
    10681 gccgcgcaac gacgtcatca acaccatgac cagcagggtc tgcgccgcac tgcggattcc
    10741 ctgggtgacc gccggctaca acggcccgct ggtgacggtc ggtgtctacg gtcccgaggg
    10801 tccgtgcttc gcctgcgtcg gtgccggcga ggaggcccgg ctgaaaccgg gctggcatcc
    10861 ggacctgggc ggcacgggag ccctggcacc ggccgccggg atctccgggc agctgatcgc
    10921 caacgaggtc gtctcgctga tcacgggtac gggctcgacc gctcccggtt acgtgcgcgg
    10981 cctgaatctg atcgcccccg accacctcgt ccacgtgcgg catcccgccc ggcccgagtg
    11041 cccgttgtgc aacccctgac cggtggtccg gaagggctcc gggtctcctt ccacggcctg
    11101 gagttccgcc ccgaccgcga cgagtggatc gtcggacggc agggcaccga cgagatcgtc
    11161 gccctgcccg cgatcggcat ggacgcggta cggctgctgt ccgccggccg gacggtggag
    11221 gagaccagga gcagcctgcg tacggccacc ggccgcgacg tcgacgtccg ggcgttcgtg
    11281 gagcggctcg cgtcggccgg gctggtggcg tccatcggcg agcggcgctt ccccgtcgcg
    11341 ccggccgcgg tctcgttccc ccgggtgcgg ccgcaccatg tgcgcctgct cctgaacccg
    11401 gtgctgcacg ccgtcctgct cctggtcccg gtcgcgggtc tcgcggtcgc gctgacgcgt
    11461 ccgggcacct tcccctcctg ggacagcttc ctgtggacgg agtacggcac cttcacggtg
    11521 ctggtccagt gcgtgatcgg ctggtgcctc atcgccctgc acgaggcggc gcacctgctg
    11581 acggcccggg cggcgggcgt gcccggccgg atccggctcg gcacccgcct tcagttcctg
    11641 gtggcgcaga ccgaggtgtc gggcatctgg ctcaagggcc ggcgggagcg gctgacggtg
    11701 tacctgtcgg gcatcgtcct ggacgcggtg atctggggcg gctgcctgct ggcccgcggc
    11761 tggggagcgg acggggtgct gctgccggtg atcgtggcga ccctgttcct ggcgctggcg
    11821 aaccagtgcc tcgtgttcat gcgcacggac ctgtacttcg tcgtccagga cctgacgggc
    11881 tgccgcaacc tgttcaccga cacggcccgc tgtctgcgcc atgtggccgc gctgcccttc
    11941 ggccgccggg ccccgcaccc cctgcggtcg ctgccctccc gcgagcggcg cttcgtccag
    12001 gcgtacgccg tcgccgtggg cgtgggcagc gtggtctgcc tggccatcgg cttccgggtg
    12061 ctgaccgagg tcacctggcc gctgctgcgc cggtccctcg tacacctggt ggacggatcc
    12121 ggctggtggc tgcggctcga cgcgctcacc accgtcctgg tcctgtgcgg catgcaggcg
    12181 ctgtgggccc gcctgtggtg gagacgccac ggcgaacggg tcaagcgcgt gcggctggcg
    12241 gcacgcgcgt ggcgacgcgg ttactgagag gagcctcata gcccgcgggc gcggtgctgg
    12301 tctacctttc cccgatgcac aaccgctcgc cccggttccg tctgctcggc ccgctggaga
    12361 tccgcgtcga cgagaccgcc gtccttctca ccggccgtca acgcgccctg tgcgcggtcc
    12421 tgttgctgca cgccgaccgt gtcgtctccg tggaccggct ggcacggggc ctgtgggacg
    12481 aacggatgcc cagcgcgtcg gccgcacgga tccgtgccct ggtctccgag gtccggcagg
    12541 ccttcggcgt ggacggagcc gccctgctgg ccacccagaa gcccgggtac gtcctgcgcg
    12601 ccgctcccgc ggaggtcgac gcgttcctct tcgaagcgct gatcagggac gggctgcggg
    12661 cgctggcgca cgaggagtgg gcgcaggcgt accgctacca cgacgacgcc ctcgcgctgt
    12721 ggcgcggcga cccgctgccc gatctgccga ccatggaagc ggaacgccgg cgcctgaccg
    12781 aactgcgcat cgccgccgag gagggcaggg cggaggccga actggaactg ggccggccgc
    12841 gctccgccgt cgccgacctg gtccggctca cctccgagca cccgctgcgc gaacgcccgc
    12901 acgcgctgct gatgcgcgcc ctggccctgg acgggcggtc gccggacgcc ctggccgtct
    12961 acaccggcct gcgcaaccgc atggtgcggg aactcggcgt cgacccctcg gacgaactca
    13021 cgggactgca ccgcaagctg ctcgccggag gtgccgcccc ccggacggcg gcgccggccc
    13081 ccgccgagcc cgccaggtcc cggcgggtgc cccgccagtt gccgcgggcc ccccaccgct
    13141 tcgtcggccg gaacgcggag ctgcgcctgc tcgacgcctg ccggcgggac ggcggtgctc
    13201 ccgccgtgct cgtggggccc gcgggcgccg ggaagaccgc gctggccctg cactgggcgc
    13261 accggatagc cgacgactac cccgacgggc agctcttcct ggacatgcgg ggcttcgaca
    13321 acgccgaacc catgtccctg gaggaggcgc tgcccctgct gttgcagggc ctgggatgcg
    13381 cgccgcacga cataccgctg ggcctggacg cgcagaccgc gctctaccgc acgctcctgg
    13441 cggaccgccg ggtcctcgtc ctcctcgacg acgtggccga cgcctcgacg gtacgccggc
    13501 tcctccccgc ggccagcggg tcgctcgcgc tggtgaccag ccggcggaaa ctgaacgggc
    13561 tcgtgctgga cggggcccac cgggtgacct gcgacgtgct gtcccgcgag gaggccctgg
    13621 agctgttcgg cgcctcgatc ggtgccgagg ccgtagcggc cgaccccgcg gcggcggccc
    13681 acctggtgga actctgcgac cacctgcccc tggccctgtg cgtcgccggt tcctggatcg
    13741 gcgccgggtc cgggagcgtg cgggcctacg tcacgagcct cgcggaacgc ggccggctcg
    13801 cccggttgca cgtcgagggg gaggagagcg tcgccgtccg ggccgcgctc gacctgtcgt
    13861 acggaacgct gcccgacgag gccaggtggg ccttccgctc cctgggtctg ctcccgggca
    13921 ccggccgctc ggtcgcggcg gccgcggccg ccgcgggact ggacgagacg cgcaccgccg
    13981 acctgttgcg gctcgcccag cgggtgcacc tgctgcgcga cgacgcgtac ggccgtatga
    14041 cctggcacga cctcgtgcac gaatacgccg cggaacgggt ggtggcggag gacgccgagg
    14101 cggagcgggc ccgggcggtc gaccgcctcc tcgaccacta cctccagagc gtctcccggg
    14161 tcgcggcgac gtgccgcctg tactgcccgc agccccttcc ggagcccgtc ggcgggtccg
    14221 ccccccgcac gttccgcacc ccggaggagg ccttcgcctg gttcgacgag gagtgggagg
    14281 acatcgcggc ggcgatcgcg tacgcggccg agcacggacc cgcccggttc gcctggcaga
    14341 tcgtcgacgc gctccaggac ctgttccacc accgccgccc gctcgccgac tggctgcggc
    14401 tggccgcgct cgccggccgg gcggccgaac gcggcggcga ccggcggggc caggcggtcg
    14461 tccacctctc ctccggccac gcccggtggc gcagcggaga cttcagaggg gccctcggcg
    14521 cctacgagag tgcgcaggcc gcggcacgcg acgccgggtg gctgtcggga gaggcgcgga
    14581 gcgctcaggg caggggggtg acgctgaagc tgctcggcga gccgagcgag gcactgccct
    14641 tctacgaccg cgccctcacc ctctaccgct ccctcggcat gacggagccc gagaagatca
    14701 tgctgaccaa cacggcgtcc ctgaagctcg cgctgggacg gctcgccgag gccgaggagg
    14761 cggtgaccgc ggcgctcgcg ctgcacgacg ggcggcagga gcacctccac tcgatgacgc
    14821 tggtgaacca cgcgctggtg cagcagaagc aggcgaggtt ccgggaggcc gccgccacct
    14881 tgtggcaggg cctggaggtc tcccgcggcg ccgcgtcgct ctacgcggaa gccgtgatgc
    14941 tggagaccct cggccgggtg cgcgacgacg cgggccagga cgcccgtgcc ctcctcgcct
    15001 acgaggacgc gctcgggctc gcccagcgcg tcggcaaccg caactgccag gtcgactccc
    15061 tggtgggtct cgccgccgtg aagctgcgca cgggccgcac gccggaggcg gccgcccacc
    15121 tcgacgaggc ccggaccgtc gccgaggaga ccgggcaccg gaccggcctg atcgagatcc
    15181 tgctggtgcg cggggccctg cactgcgcgc aggagcggta ccgggaagcg gcggcggtac
    15241 tggagacggc cggccggctc gcggtgaacg gcagtcccct cacgctgccc cggatccgga
    15301 ccctcggcgc cgtggccctc cgggagaccg gtgagaccgg cgccgccctc gaggcggcac
    15361 gcgaagcggt cggccaggcg cgcaactcgg gtcagcgcct ggtgctggcc cgtgcggcga
    15421 ccgccctcgc gagcgtctgc gaggccgtcg gcgacacccg ggccgccgcc gggcaccggg
    15481 acgaggcccg cgtcctgttc gacgagatcg gcgtcccgtc ctcccaccgg acggccaccg
    15541 gacacccggg cgccggcacc ccgccggacc ggggcccccg cgcccggggt gcgcgcccct
    15601 gcctgccgga cgacacggag gagcgcttcg cgcgctatct cgccgaccac ttcgacgacc
    15661 tcgcgggcca gcaggtgccg cggccctagg acgccatggc cgcccacacc ggacggccgc
    15721 cctgcacgac ctcgtccctg cgcaggatcc gctcgtgcag catgcgcagc cggctcccgg
    15781 gctcgacgcc gagctccgcg accagccgcg cgcgggtgga acggaagcag cgcagcgcct
    15841 cgtcctggcg cccgctgcgg tagagcgcca gcatcagcag gctggcgatc cgctcgtcca
    15901 gggggtgggc ggcggccagc tcgtggagca gcggcacgta gtcgccgcag cggccgagcc
    15961 cgagcgccag ttccgcgctg ttggtccgga cggtgcgcag ttcccgctcg aacgtgatcc
    16021 gggcggcgtc cgcccacgcc gtccggacat cggacagcgg ccggccgtgg cacagggcca
    16081 gcgcctgctc gtagaactgc aaggccgcct cctccgctcc ccggcactgc gcgttcctgg
    16141 cctgccgcac gagggcacgg aagccgagga catcgacggc ctcctccgcc gcgaccatgg
    16201 tgtagccgcc cggcctgcgg accacgtcgc acggcgcacc gggggcgccg accgcccgca
    16261 gcgccttccg cagccgggtc accaaggtgt agagggcgtc gcgggggcgg accgggaccc
    16321 tgctctccca gacccggccg atcgtgtcct cgtcggtgac gaaggagttg gcggaccagg
    16381 ccagcgtggc caggaggcga ctgacggtgg gactgaccgc aatgttttgg ccatcggcgg
    16441 cacgaagctc ggtacaaccc aggatctgta cgttcacgcg gtcccctgaa ggtgtcgtcg
    16501 gtctgctgtc accagcacct cccactgtgg ggaccgggcg ttcgttttcc gcatggatca
    16561 cgcacgggcg ggctgcgccg gcgcgcccag cggccgtact cgcggcccgg cggcgggggc
    16621 cggcggcgag ggcgggaatt ccctcgatcg accgcgcaat ggatcaccga aatgagatgc
    16681 gaagtcgtta ctttgcgacc ctccggtgta cgcattccga cgactcggcg tccacataac
    16741 gaacaccttg cctgattcgt ccagttggcc cgatgtaaag cacggatcga tcacggcgcg
    16801 ctacacgcgt agctacggaa tgatcaagat gaagcaaaga aggtaaagag aaagtcaact
    16861 cgagccagat tttattgacc ttgaacgaat tgcgttgaaa aagtccggcg tagcccgtag
    16921 ggggacgccc tgcggagtca tcagaccctc ccttgggcca ggagcaccat gaccccccca
    16981 actccatcag cggccgcccc gctcgaggtg accgacgaaa ccgtcgacaa gtcacccacg
    17041 cccgccaccc ccaagggcag cgaaagccgt tcgccgggcc gactggcctg gaagcgcttc
    17101 aagcgtgacc gcacgggcgt catatcggcg tgcatcgtga tcttcttctt cgtgatcgcg
    17161 ctcgcggcgc ccctcatagc caagctgtac ggcaaggacc cgtacaccac gtacgccagc
    17221 cagcgccccg aactgctcga cgccttctcg tacccggccg gtcccaacgg cggtatgagc
    17281 tcggagttct ggttcggcat cgagccgcag ctcggccggg acgtgttcac cttcctgctg
    17341 tacggcatcc ggacctcgct gggactcgcg ctggccgcca cggtggtcac ggccgtcctc
    17401 ggcgtcgtga tcggcaccac ggcgggctac ctcggcggca agacggacta cttcgtcggc
    17461 cggatcatcg acatcctgct gtcgttcccg tccacgctgt tcttcatcgc gttcatgccg
    17521 gtcatctacg gcctgttcgt cgcgccggac gagaacatcc ccacctccct gcgggccatc
    17581 tccctcatca tcgtgctgtc cggcttcggc tgggcgtccc tcgcccggct gctgcgcggc
    17641 caggtgctcg gactgcgcga gcgggagttc gtggaggcgg cgaaggtcac gggcgcgtct
    17701 ccctggcgca tcgtcttcaa ggagctgctc ccgaacctct ggactccgat catcatccag
    17761 accacgctga tgctgccgat gttcgtcacc gcggaagcgg ggctggcatt cctcggcgtc
    17821 ggcatgatcg acccgacgcc ggactggggc gtaatgatcc agcgaggcgc ccagttctac
    17881 accgaggaca tcaccttcat gctcttcccg ggcctctcca tggtgatctt cgttctcgcc
    17941 ttcaacctgc tcggcgactc ggtgcgcgac gcgctcgacc cgaagaccaa gcgctgatcc
    18001 gttccttccc cggtccgtac acaggagtcc ggccggccat ctccgtcccg tatgaccacc
    18061 cttggtaggt tctccatggc tttctcccgc agaaacttcc tcatagcgac cggtgtcgtc
    18121 gcggcctcct cctcggtcct gaccgcctgt ggcggcagcg acaacaaggg cggcggcaag
    18181 agcgacgccc cgaaggtcag cggctccaag accgtcgaga tcctggtcgg cacgaaggcc
    18241 gactcgaccg gtcctgcgcc ggaggtcaag ggcgcggtga agggcgggat catccactcg
    18301 ctcgaccagt tcgacatgga ccacatggac ccggcgcaga tctacgtctc gaccgagggc
    18361 gccatcaccg tgccgatcat gcgcggtctg accggctaca agatcgacga caagggcggc
    18421 tgcaccctgg tcggcgacgt cgccaccgac gccggcacga tgaaggacgg cggcaagacc
    18481 tggtccttca ccatcaagga cggcgtgaag tgggaggacg gctccgacct ctccatggac
    18541 gacgtccgcc acacctacga gcgcctcttc gcggacttca tcaccgaggg cccgcgctac
    18601 gtgcagcagt tcctggtcgg cggcgacaag tacaagggcc cctacgaggg caagcacctc
    18661 gactccatcg agatcgacgg caagaccgtc accttccgcc tcaacgagcc ccgcgccgac
    18721 ttcaacttca cgctggccat gcgcggcttc tccctcgtgc ccaaggcgaa ggacaccaag
    18781 cagaagtacg acagccgtcc gttctcctgc ggtccctaca agatcagcga gcgcagcgtc
    18841 ggcaagtccc tgacctacgt gcgcaacgag cactgggacc cgaagacgga cgcgatccgc
    18901 aacgcctacc cggacgagta ccgcttccgg ttcggctacc agccgctggc cgccaccgac
    18961 cgcttcatcg ccgactccgg cgaggaccag caggccatgg cgatcttcaa cgaggtcgcg
    19021 ccggagcgca tcgccaaggt gctcaccgac ccgaacctga agaagcgcgt cctcaccgcg
    19081 gtggacacgg tcacctacta ctggccgatc aacaccaccc gcatcaagga cgtcaaggtc
    19141 cgtcaggcca tcaactgggc ctggccgcac cagcagctcc agacgatccg cggcggcgcc
    19201 tccaccagtg agctggccac cacgatcctc agcccggtga cccccggcca cgaggaattc
    19261 gacctgtacg gcgtcgacaa gaagcccggc ggcgacccgg agaaggccaa ggcgctgctg
    19321 aaggaggccg gcaaggtcgg tcagaagctg gtcatcgcgt accagacctc ggacaacgcg
    19381 ctgaagcagg ccgtcgcgat caagaacgcc ctggaggccg cgggcttcga ggtcgtcaac
    19441 aagcagctcg acaagtcgac cttctacacc cagatcggca agatcgacaa cggctacgac
    19501 ctgttcgcgg ccggctggag cccggactgg ccgaacggct actcggtctt ctacccgtgc
    19561 tggagcggcg agaacatcgg cgacggccgc agcaactacg cccagctcga cgaccccagc
    19621 gtgaacaagg cgatcaacgc cgcgtccaag atcgccgacg cggaagcggc caacaaggcc
    19681 tggggcgcca tcgaccgcca gatcatggag ctcgcggccg tcgtgcccga ctaccactcc
    19741 atccgcaact ggatgtacgg atcgaagatc ggcaacgtgg tgttcgacta cggcaacacc
    19801 tgcatcgccc tctgcaagct gtacgtcaag aagtaagcgc gcagacgcac aggggggcgg
    19861 ccacacccat ggccgccccc ttgaggccca cccccctctc accccggcga cggcgccccg
    19921 tccggaaagt cacgccccat gttccgcttc ctagtccgcc gagtcttcgg cgcgttggtc
    19981 attctgttga tcatcagcgc catcaccttc tggctcttct acgccgtgcc gcgcgacccc
    20041 gccatgatgt cctgcggcaa gaactgcacg ccggaaaacc ttgagcagat ccggaagaac
    20101 ctgggcatcg acgagtcgat cgtcatgcag tactggcact ggctcaccgg tatcttcgcg
    20161 ggccgcgact acgccggcta cggccgctgc gacgctccct gcctcggcta ctcgttcgcc
    20221 aacagcgagc ccgtctacgg cacgatcatg gaccggctgc ccacgaccct gtcgctcgcc
    20281 ttcggcgcgg ccatcttctt cctgatcatc ggcatcggcg ccggcatgct cgcggcctcg
    20341 aagcagggca agttcctgga caagttcgcc agctccgtgt cgctgctcgg ctcctcgctg
    20401 cagatctact tcgttggcta catcgccatg ttcttcctgg tcggtgagct cggcatcctg
    20461 agccagccgt cgtacacgcc gctgaccgac gacccggtcg cctggatgtc cggcctgttg
    20521 ctgccctggc tggtgctgtc gatcatcttc accgccaact acacccgtat gacgcgctcc
    20581 cagatggtgg agcagctcag cgaggactac gtgcgcaccg cgcgggccaa gggcctgtcg
    20641 aggcgcaacg tcttcttccg cttcgcctgg cgcggtgcga tgggccccat cgtcaccatc
    20701 ttcggcgtcg acctcggtgt gctgatcggt ggtgccatca tcaccgagac gaccttcagc
    20761 atccagggca tcggccggct cgcgatcgag tccgtgttca agagcgacct gcccatgctg
    20821 ctcggcgtca ccgtgctggc ggccggcgcc atcgtgatgt tcaacatcgt cgtcgacgcg
    20881 gtctacgccc tcatcgaccc gcggatccgg ctcgcctgat ctccgcccgc cacagtcgcc
    20941 tctcccaccg cctcacccgg ctaccccccg catcacctcc tggagcgtcc ccgtgacgag
    21001 caccgaacag cagcccttcc tctccgtcag ggacctgaag gtccacttct ccaccgagg
//
