LOCUS NZ_KZ195574 21158 bp DNA linear CON 06-SEP-2024 DEFINITION Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence. ACCESSION NZ_KZ195574 VERSION NZ_KZ195574.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. CS113 ORGANISM Streptomyces sp. CS113 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C., Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines JOURNAL Front Microbiol 9, 39 (2018) PUBMED 29441046 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for glycosylated natural products in actinomycetes isolated from leaf-cutting ants: activation of two silent clusters and identification of a novel macrolactam JOURNAL Unpublished REFERENCE 3 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Direct Submission JOURNAL Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia, Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006, Spain COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.9 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 78.17x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_002188365.1-RS_2024_09_06 Annotation Date :: 09/06/2024 02:31:13 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,790 CDSs (total) :: 7,719 Genes (coding) :: 7,614 CDSs (with protein) :: 7,614 Genes (RNA) :: 71 rRNAs :: 2, 1 (5S, 16S) complete rRNAs :: 2 (5S) partial rRNAs :: 1 (16S) tRNAs :: 65 ncRNAs :: 3 Pseudo Genes (total) :: 105 CDSs (without protein) :: 105 Pseudo Genes (ambiguous residues) :: 0 of 105 Pseudo Genes (frameshifted) :: 35 of 105 Pseudo Genes (incomplete) :: 81 of 105 Pseudo Genes (internal stop) :: 4 of 105 Pseudo Genes (multiple problems) :: 15 of 105 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 09:56:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 2956836 Orig. end :: 2977994 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to KZ195574.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Prof. Salas's laboratory, A. Microbiology, University of Oviedo, Spain. FEATURES Location/Qualifiers region 1..21158 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene-precursor" /region_number="19" /rules="(PT_FPPS_like and not PT_HPP)" /tool="antismash" cand_cluster 1..21158 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_FPPS_like and not PT_HPP)" /kind="single" /product="terpene-precursor" /protoclusters="1" /tool="antismash" protocluster 1..21158 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:11158](-)" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" /tool="antismash" proto_core complement(10001..11158) /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" gene complement(82..1047) /locus_tag="B9W62_RS12665" /old_locus_tag="B9W62_12705" CDS complement(82..1047) /NRPS_PKS="Domain: PKS_ER (20-318). E-value: 9.3e-34. Score: 108.9. Matches aSDomain: nrpspksdomains_B9W62_RS12665_PKS_ER.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018571395.1" /locus_tag="B9W62_RS12665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12705" /product="zinc-binding dehydrogenase" /protein_id="WP_087807278.1" /sec_met_domain="ADH_zinc_N (E-value: 6.9e-20, bitscore: 70.2, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MFAVYAARIDRDQPLAGLELGELPAPEARPGWSVVDVRAASLNHH DLWSLRGVGLPEDRLPMILGCDAAGIDADGNEVVLHSVIGQTGHGVGPKEPRSILTERY PGTFAEQVAVPTWNILPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAG GGVATAAIVLGKAAGLRVFATSRDEAKRKRALELGAVEAVETGARLPQRVDAVIETVGA ATWSHSIKSLRPGGTLVISGATSGDRPSHAELTRIFFLELKVVGSTMGSKDELEDLLSF CAATGVRPVIDEVLPMDRAREGFERMASGGQFGKIVLSNS" aSDomain complement(94..987) /ASF="ER configuration inconclusive" /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_B9W62_RS12665_PKS_ER.1" /evalue="9.30E-34" /label="B9W62_RS12665_PKS_ER.1" /locus_tag="B9W62_RS12665" /protein_end="318" /protein_start="20" /score="108.9" /tool="antismash" /translation="GELPAPEARPGWSVVDVRAASLNHHDLWSLRGVGLPEDRLPMILG CDAAGIDADGNEVVLHSVIGQTGHGVGPKEPRSILTERYPGTFAEQVAVPTWNILPKPK ELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGLRVFA TSRDEAKRKRALELGAVEAVETGARLPQRVDAVIETVGAATWSHSIKSLRPGGTLVISG ATSGDRPSHAELTRIFFLELKVVGSTMGSKDELEDLLSFCAATGVRPVIDEVLPMDRAR EGFERMASGGQFGKIVL" CDS_motif complement(535..588) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_B9W62_RS12665_0002" /evalue="6.00E-05" /label="PKSI-ER_m5" /locus_tag="B9W62_RS12665" /protein_end="171" /protein_start="153" /score="15.7" /tool="antismash" /translation="GDSVLVQGAGGGVATAAI" CDS_motif complement(619..657) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_B9W62_RS12665_0001" /evalue="5.60E-04" /label="PKSI-ER_m4" /locus_tag="B9W62_RS12665" /protein_end="143" /protein_start="130" /score="13.4" /tool="antismash" /translation="AACLPTAWLTAYR" gene complement(1317..2546) /locus_tag="B9W62_RS12675" /old_locus_tag="B9W62_12710" CDS complement(1317..2546) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997977.1" /locus_tag="B9W62_RS12675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12710" /product="NADP-dependent malic enzyme" /protein_id="WP_087807280.1" /transl_table=11 /translation="MAAEIVNPRSDSEAGAEQKEGAEPLDAFDPAFALHRGGKMAVQAT VPIRDKDDLSLAYTPGVAKVCSAIAEQPDLVHDYTWKSSVVAVVTDGTAVLGLGDIGPE ASLPVMEGKAILFKQFGGVDAVPIALNCTDADEIVETVVRLAPSFGGVNLEDISAPRCF EIERKLQERLDIPVFHDDQHGTAVVTLAALRNAARLSGRTLGELRAVISGAGAAGVAIA KMLVEAGIGDVAVADRKGVVSADRDDLTPVKQELASFTNKAGLSGPLEAALAGADVFIG VSGGTVPEPAVASMAEGAFVFAMANPNPEVHPEVAHKYAAVVATGRSDFPNQINNVLAF PGIFAGALQVRASRITEGMKLAAAEALASVVGDDLAADYVIPSPFDERVAPAVTAAVAA AARAEGVARR" misc_feature 2575..2590 /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 18.76" /tool="antismash" misc_feature 2626..2641 /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 19.47" /tool="antismash" misc_feature 3070..3085 /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 20.94" /tool="antismash" gene 3183..4145 /locus_tag="B9W62_RS12685" /old_locus_tag="B9W62_12715" CDS 3183..4145 /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1091: glutamine-binding lipoprotein glnH" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973710.1" /locus_tag="B9W62_RS12685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12715" /product="ABC transporter substrate-binding protein" /protein_id="WP_087807282.1" /transl_table=11 /translation="MTARFTRRTTAAHSRLAAVGAIAVAGALLLTGCGDQTENGDSSGS DNQSAAGAPLADKLPQSIRDKGTIKVGSDIAYAPVEFKDDSGKTVGIDPDLADALGKQL GVKFEFENGTFDTLITGLRSKRYDIAMSAMTDTKDRQEGIDSDTGKKVGQGVDFVDYFT AGVSIYTKKGDNQGIKTWSDLCGKKLVLQRGTVSEDLAKAENEKCPAGKKISMEAFDND QQAQTRLRAGGADAGSSDFPVAAYAVKTSGGGKDFELVGEQVEAAPYGIAVAKDNAQLR DALKAALDAVIANGEYKKIMDKWGVAEGAVTEAAVNGGK" gene 4176..5126 /locus_tag="B9W62_RS12690" /old_locus_tag="B9W62_12720" CDS 4176..5126 /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /GO_process="GO:0006865 - amino acid transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1096: polar amino acid ABC transporter, inner membrane" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973711.1" /locus_tag="B9W62_RS12690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12720" /product="amino acid ABC transporter permease" /protein_id="WP_087807283.1" /transl_table=11 /translation="MTVDIDKTAGGPAGNPPTPPEAIKAIPVRHYGRYVSAVVAIALLA AVVYAFSQGKINWGAIPDYFFDDRVLTGMGKTLLITVLAMLIGIVGGILLAVMRLSKNP VTSSIAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGL GLNEAAYMAEICRAGLLAVDEGQTEAAHALGMSHSRTLRRIVVPQAMRVIVPPTGNEVI NMLKTTSLVSVVQYAELFRVAQDIGQTSGAPAEMLFLAAAWYLLLTSVFSVGQYYLERY YARGSSRSLPPTPMQKIRANLFSLSNRSSTTGGAA" gene 5123..5884 /locus_tag="B9W62_RS12695" /old_locus_tag="B9W62_12725" CDS 5123..5884 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973712.1" /locus_tag="B9W62_RS12695" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12725" /product="amino acid ABC transporter ATP-binding protein" /protein_id="WP_087807284.1" /transl_table=11 /translation="MTAMVKAEGVHKSFGAVEVLKGIDLEVEQGEVFCLIGPSGSGKST FLRCINHLEKINAGRLYVDGELVGYRQKGDRLYELKDSEVARKRRDIGMVFQRFNLFPH MTAVENVMEAPVQVKGMSRPQARERARALLERVGLGDKAGNYPSQLSGGQQQRVAIARA LAMDPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMVVVTHEMGFAREVGDSLVFM DDGVVVESGNPRDVLTDPQHDRTKAFLSKVL" gene complement(5946..6758) /locus_tag="B9W62_RS12700" /old_locus_tag="B9W62_12730" CDS complement(5946..6758) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1089: methyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004983528.1" /locus_tag="B9W62_RS12700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12730" /product="trans-aconitate 2-methyltransferase" /protein_id="WP_087807285.1" /transl_table=11 /translation="MTNADTTTTTTTATPAATPATAAGADWQAWQQSWDRQQEWYMPDR EERFRIMLDMVEALVGTAPRVLDLACGTGTITARLLDRFPQATSTGVDLDPALLAIAEG TFAGDERVSFVTADLKDPDWPSKLPYGSYDAVLTATALHWLHADPLADLYGRVADLVRD GGVFMNADHMIDDTTPRINAAERAQRHARMDAAKEQGALDWAEWWQLAAKDPVLAGPTA RRFEIYGEHADGDMPSAAWHARVLREKGFGEARPVWCSPSDTLLLAVK" gene 6857..7486 /locus_tag="B9W62_RS12705" /old_locus_tag="B9W62_12735" CDS 6857..7486 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019326935.1" /locus_tag="B9W62_RS12705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12735" /product="ABATE domain-containing protein" /protein_id="WP_087807286.1" /transl_table=11 /translation="MELAYYSDYAVRLVNTEEPSRGQDSLTSVEAVRDLFGANQSAARR ASDADVTRFRSVRGRLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRAEDGS PLWHMHLADHPSNATAGFAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSR RYCSDRCATRANVAAYRARKRLEADRSASTGLTADSTQRTTASGER" gene complement(7390..7827) /gene="sodX" /locus_tag="B9W62_RS12710" /old_locus_tag="B9W62_12740" CDS complement(7390..7827) /GO_function="GO:0004252 - serine-type endopeptidase activity [Evidence IEA]" /GO_process="GO:0016485 - protein processing [Evidence IEA]" /GO_process="GO:0019430 - removal of superoxide radicals [Evidence IEA]" /codon_start=1 /gene="sodX" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004925778.1" /locus_tag="B9W62_RS12710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12740" /product="nickel-type superoxide dismutase maturation protease" /protein_id="WP_179235464.1" /transl_table=11 /translation="MPEQLSQETERARGTLPFGPAEVTGPSMVPTLHHGDVLLVHWGAR VRPGDVVVLRHPFQQDLLVVKRAAERRGTGWWVLGDNAFAGGDSTDYGVVPQDLVLGRV RFRYRPPRPGQRSPLAVVRWVLSAVRPVLADRSASRRLRAR" gene 7973..8368 /gene="sodN" /locus_tag="B9W62_RS12715" /old_locus_tag="B9W62_12745" CDS 7973..8368 /EC_number="1.15.1.1" /GO_function="GO:0004784 - superoxide dismutase activity [Evidence IEA]" /GO_function="GO:0016151 - nickel cation binding [Evidence IEA]" /GO_process="GO:0019430 - removal of superoxide radicals [Evidence IEA]" /codon_start=1 /gene="sodN" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009313646.1" /locus_tag="B9W62_RS12715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12745" /product="superoxide dismutase, Ni" /protein_id="WP_003973716.1" /transl_table=11 /translation="MLSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN DDPHFQTRATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKG SKDPATGQKALDYIAQIDKIFWETKKA" gene complement(8533..9117) /locus_tag="B9W62_RS12720" /old_locus_tag="B9W62_12750" CDS complement(8533..9117) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973718.1" /locus_tag="B9W62_RS12720" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12750" /product="dihydrofolate reductase family protein" /protein_id="WP_087807288.1" /transl_table=11 /translation="MRKLTYFVACSIDGFIGGPDGDATFMVPFVDEEFFAFLKSEYPET LPTHGRRPLGIDDLPNKRFDTIVQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDP NVEIISTDLVGRVRELKAEDSAFDIYLCGGAAVAGELADEVDELVIKSYPVVLGTGMPM FASGFAVSEFVTDSVRTFGNGVVVRTYHRKR" gene complement(9194..9790) /locus_tag="B9W62_RS12725" /old_locus_tag="B9W62_12755" CDS complement(9194..9790) /EC_number="2.3.1.-" /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007444621.1" /locus_tag="B9W62_RS12725" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12755" /product="N-acetyltransferase" /protein_id="WP_087807289.1" /transl_table=11 /translation="MGVVIRTAGEDDRDLVVRLLDEAFQDDPVSSWVFPGEEYRRRTHH RLMAAFADAVFADGRIDLTEDGAACALWLPVPADEHTAAEDAPAQIREAVDPENERVEL IARLTDGIHPTGRAHEYLWMIGVLPGRQGEGLGTALIESVLDRCDRERLPAYLEASSAR GKALYERLGFEFTGRALDLPDGPRMWPMWREPQTR" gene complement(10001..11158) /locus_tag="B9W62_RS12730" /old_locus_tag="B9W62_12760" CDS complement(10001..11158) /GO_component="GO:0140737 - encapsulin nanocompartment [Evidence IEA]" /GO_process="GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene-precursor: PT_FPPS_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182: Polyprenyl synthetase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973720.1" /locus_tag="B9W62_RS12730" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12760" /product="family 2 encapsulin nanocompartment cargo protein polyprenyl transferase" /protein_id="WP_087807290.1" /sec_met_domain="PT_FPPS_like (E-value: 1.5e-61, bitscore: 206.8, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MTETRRGGTATRRPTGAPERHGPIGTQREKEPAESSDGPGRAAEG HEAAVLLSESRASVDPELRSAIASLPESMRRIALYHFGWQHADGTPAAGNAGKAIRPAL VLTAATALGGPAARAAAGRAAAAVELVHNFTLLHDDVMDRDATRRHRPTAWTVFGDADA ILAGDALQALALRLLAADPHPASAAAAARLADCVMELCEGQHADTAMERRPPGEVTLDE TLAMAEAKTGALLGCACALGALYAGAATEDVEALDAFGREAGLAFQLIDDVIGIWGDPR HTGKPAGADLAARKKSLPVVAALTSGTTAAAELAELYAAPYDEGKEDLERTALAVERAG GRDWAQAQAADHMAKAMQELARAVPEPEAAGGLLALAEFVTRRST" misc_feature 11186..11201 /note="TFBS match to CsoR, Copper-responsive repressor, confidence: weak, score: 22.47" /tool="antismash" misc_feature complement(11186..11202) /note="TFBS match to RicR, Copper-responsive regulator, confidence: weak, score: 21.43" /tool="antismash" gene complement(11244..12650) /locus_tag="B9W62_RS12735" /old_locus_tag="B9W62_12765" CDS complement(11244..12650) /GO_component="GO:0140737 - encapsulin nanocompartment [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020136651.1" /locus_tag="B9W62_RS12735" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12765" /product="family 2B encapsulin nanocompartment shell protein" /protein_id="WP_087807291.1" /transl_table=11 /translation="MSVGEEVRTEQTRPQQSLGTAAARNLATTTKSVPQMQEISSRWLL RSLPWIDVQGGTYRVNRRMTFAVGDGRVTFVKTGDRVEVIPAELGELPALRSYEDDEVL SELAQRCEQREFGPGEVIASFGGRADEVYLLAHGKIEKIGTGPYGDDAVLGVLADGAYF GDQALLDGDAIWEFTARTVTACTVLVLPRQEVEQVAERAESLREHLEQRRSIPEQRTNK HGEKEIDLAAGHSGEPDIPHTFVDYEARPREYELSVAQTVLRIHSRVADLYNQPMNQTE QQIRLTVEALKERQEHELINNREFGLLHNCEYDQRIQPHEGVPGPDDLDELLSRRRGTK LLLAHPRAIAAIGRELNKRGLVPETIDVAGNRIPTWRGVPIYPCNKIPVTEARTSSIIA MRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAVIKYLVTAYYSAAVLVPDALGV LENVEIGRWR" misc_feature complement(12718..12731) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: medium, score: 20.09" /tool="antismash" misc_feature complement(12812..12826) /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 18.0" /tool="antismash" misc_feature complement(12953..12966) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.81" /tool="antismash" gene 12989..13567 /locus_tag="B9W62_RS12740" /old_locus_tag="B9W62_12770" CDS 12989..13567 /EC_number="3.5.1.28" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine amidase activity [Evidence IEA]" /GO_process="GO:0071555 - cell wall organization [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030135.1" /locus_tag="B9W62_RS12740" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12770" /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="WP_087807292.1" /transl_table=11 /translation="MSASSFLKALKAEGLTVVEVGDWRDHNRNHKGPWGPVNGVMIHHT VTRGSARTVEICRKGHESLPGPLCHGVITKDGRVHLVGYGRANHAGLGDDDVLRAVVAE KALPRDNEANTDGNRHFYGFECENLGDGKDPWPAAQLDAIERAAAAVCRHHGWNERSVI GHLEWQPGKVDPRGFTMASMRERIRDRLK" gene 13824..14732 /locus_tag="B9W62_RS12745" /old_locus_tag="B9W62_12775" CDS 13824..14732 /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PALP" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973723.1" /locus_tag="B9W62_RS12745" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12775" /product="1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase" /protein_id="WP_087807293.1" /sec_met_domain="PALP (E-value: 6.7e-18, bitscore: 63.9, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MTGTDTRDLAALRPRLPSPLHEVADGRFERRGVRLLLKRDDLIHP ELVGNKWRKLAPVLAAADGRTVVTFGGAYSNHLRAAAAAGRLLGLSTVGVVRGQELAGR PLNPSLARCAADGMRLHFVDRSTYRRKSEPETLAALLRAVDAEGAVVVPEGGSNTEAVR GCRALGEELGEHADVAALACGTGGTLAGLAAGLPRGRRALGIPVLRGGFLEGDIRRLQE RAFGGPRGTWSLDDRFHHGGYARTTPALDAFAEDFERRHGLPVERVYVAKMLYALLALT EEGAFPRGTALAAVVTGRPFP" gene complement(14799..16391) /locus_tag="B9W62_RS12750" /old_locus_tag="B9W62_12780" CDS complement(14799..16391) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0015385 - sodium:proton antiporter activity [Evidence IEA]" /GO_process="GO:0006814 - sodium ion transport [Evidence IEA]" /GO_process="GO:0006885 - regulation of pH [Evidence IEA]" /GO_process="GO:1902600 - proton transmembrane transport [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973724.1" /locus_tag="B9W62_RS12750" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12780" /product="Na+/H+ antiporter" /protein_id="WP_087807294.1" /transl_table=11 /translation="MDVMPLLLLVAGSAAIAAAGRRVPVPVPLLLVAAGLAVSYVPGVP DYTLDPHIVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLI VPGLPLTAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVA LAAAVGEGATWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFV AYAVAEQVHASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGL QLPVVLKGLGEYEGIDAAWYALAVFLVVAVARFVWVYPATFLPRLSARVRAREGDLSWK GPFVIGWAGMRGVVSLAIAFSIPLTVHGGEPFPERNLILFLTFTTVIGTLVVQGVSLPP LIRLLKFPAHDVQAETLAEANAQAQASRAAELHLDELLADERNALPAPLADRLRMVLER RRNAVWERLGQVNPVTGETVDDTYRRLSREMISAEREVFVRLRDGRYIDDEMLRTLLRR LDLEEAAAYRETT" gene 16453..16713 /locus_tag="B9W62_RS12755" /old_locus_tag="B9W62_12785" CDS 16453..16713 /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018571357.1" /locus_tag="B9W62_RS12755" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12785" /product="UBP-type zinc finger domain-containing protein" /protein_id="WP_087807295.1" /transl_table=11 /translation="MKQCTHADALPHPEPEPCGETCPECLAEGTDPVQLRLCLSCGHVG CCDSSPRQHATAHYKETGHPVMRTFEPGESWRWCFVDHVLV" misc_feature complement(16822..16835) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 18.89" /tool="antismash" gene 16964..17377 /locus_tag="B9W62_RS12760" /old_locus_tag="B9W62_12790" CDS 16964..17377 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003966375.1" /locus_tag="B9W62_RS12760" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12790" /product="anti-sigma regulatory factor" /protein_id="WP_004925829.1" /transl_table=11 /translation="MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTV LSALAGKVSSAVDEDKTVSISLYKQRGAGPGPA" gene 17395..18459 /locus_tag="B9W62_RS12765" /old_locus_tag="B9W62_12795" CDS 17395..18459 /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1032: RNA polymerase, sigma-24 subunit, ECF subfamily" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020136656.1" /locus_tag="B9W62_RS12765" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12795" /product="RNA polymerase sigma factor SigF" /protein_id="WP_179235465.1" /transl_table=11 /translation="MRDEERGTRELPAEGTRSPNEARRTADGIDGIPEQARPHPEDETS PEAVVPGDGQRTGDTPVRPVRAEAGARERATGGTMSEHERHSEGQAPGARGAQGTRHDP QDRSGARLLFAELRTLTKDSPEYAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVA TIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTAT AELSQLHGRSPTVHELAEKLSISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLG AEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLA RTLAQLREKLLVEE" gene complement(18508..18981) /locus_tag="B9W62_RS12770" /old_locus_tag="B9W62_12800" CDS complement(18508..18981) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019326947.1" /locus_tag="B9W62_RS12770" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12800" /product="hypothetical protein" /protein_id="WP_087807297.1" /transl_table=11 /translation="MSSEQTPTTPASAAADADARAEAADPRPGRLTAAAALAALEGLAL VVGGAWMLVEGLTGHPDDRTSAVTGGVTLIVLALLPLLAARGLIGRKGWSRGPAVITQI MALPVAYNMVRADSLAVPAGIVLGVVAVTALVLLVNPTTTQALGIRGPGSAEK" gene 19109..20077 /locus_tag="B9W62_RS12775" /old_locus_tag="B9W62_12805" CDS 19109..20077 /EC_number="2.7.1.-" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0008654 - phospholipid biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006127486.1" /locus_tag="B9W62_RS12775" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12805" /product="diacylglycerol kinase family protein" /protein_id="WP_087807298.1" /transl_table=11 /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD LGRQAAQSDDIDLVVALGGDGTVNEVVNGLLHAGPDPEHLPGLAVVPGGSTNVFARALG LPNHAVEATGALLDALREGSERTVGLGLASGTPGSEDEGVPARWFTFNAGLGFDAGVVG RVEQHRERGKKSTHALYVRQVVRQLIGEPHRRSGTITLERAGEDPVTDLVLSIVSNTCP WTFLGNRPIYASPEASFDTALDVFGLSRLSTAAVARYGTQLLTSSPERGPRGRHAVSLH DLTDFTLHSKVPLPLQMDGDHLGLRTSVAFTGVRRALRVIV" misc_feature complement(20162..20176) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: weak, score: 15.74" /tool="antismash" misc_feature complement(20167..20176) /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: medium, score: 15.86" /tool="antismash" misc_feature complement(20338..20353) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: strong, score: 18.39" /tool="antismash" misc_feature 20341..20352 /note="TFBS match to CcpA, Catabolite control protein A, confidence: weak, score: 15.69" /tool="antismash" gene 20398..20655 /locus_tag="B9W62_RS12780" /old_locus_tag="B9W62_12810" CDS 20398..20655 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0051536 - iron-sulfur cluster binding [Evidence IEA]" /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018563321.1" /locus_tag="B9W62_RS12780" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_12810" /product="WhiB family transcriptional regulator" /protein_id="WP_003973730.1" /transl_table=11 /translation="MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA" ORIGIN 1 tcgcccgacg gccgggaccg gcgcccggca acgcgaacgg cgggcccgga gaaccggacc 61 cgccgcaggt ggggaaacgc gtcaggagtt gctgagcacg atcttgccga actgcccccc 121 ggaggccatc cgctcgaacc cctcacgagc ccggtccatc gggagcacct cgtcgatgac 181 gggccgtaca ccggtggcgg cgcagaagga cagcaggtcc tccagctcgt ccttggagcc 241 catcgtggag ccgacgacct tgagctccag gaagaagatc cgggtcagct cggcgtggga 301 gggccggtcg ccgctggtgg caccggagat gaccagcgtg ccgcccggcc tgagcgactt 361 gatcgagtgc gaccacgtgg cggcgcccac ggtctcgatc acggcgtcca cccgctgcgg 421 cagccgcgca ccggtctcga cggcctccac cgccccgagc tccagggccc gcttgcgctt 481 ggcctcgtcc cggctggtgg cgaagacccg cagcccggcc gccttgccga gcacgatcgc 541 ggccgtggcg accccgccgc cggcgccctg caccagcacc gagtcaccgg gacgcacccc 601 ggcgttggtg aacagcatcc ggtacgccgt cagccatgcg gtcggcagac aggcggcctc 661 ctcgaaggag agctccttgg gcttgggcag gatgttccag gtcggcacgg cgacctgctc 721 ggcgaaggtc cccgggtagc gctcggtgag gatggagcgg ggctccttgg ggccgacacc 781 gtggccggtc tgtccgatca cggagtgcag gacgacctcg ttgccgtccg cgtcgatccc 841 ggcggcgtcg cagccgagga tcatcggcag ccggtcctcg gggaggccga cgccgcgcag 901 ggaccacagg tcgtggtggt tgagggaggc ggccctgaca tcgacgacac tccagcccgg 961 ccgggcctcg ggagccggaa gctctcccaa ctccaggccg gccaacggct ggtcgcggtc 1021 gattcgggcg gcgtagacag cgaacatgac cttgacgata ggttccccac cgcccatccg 1081 aaaccacaag cccgtgtgac acaccccctc ttgccagccc ccctcagctg cgggcagtcg 1141 tgccgctggg gcggcacggg tgggcgcagc ggcacccgcc cagcaccggt cagcgccccc 1201 accccccacc ccgcgcccag cgcacccgca cccgcgtcgg cacacgcacc ggcaaagaca 1261 agcggccccg cccaccgagg gacgggaccg ctcaccacac cgcagggatc acaccgtcac 1321 cggcgcgcaa ccccctccgc ccgggccgcc gcggccaccg ccgccgtcac ggccggcgcg 1381 acccgctcgt cgaacgggga cggaatgacg tagtccgcgg cgaggtcgtc ccccaccacg 1441 gaggccagcg cctcggccgc cgcgagcttc atgccctcgg tgatccgcga cgcccgcacc 1501 tggagcgcgc ccgcgaagat gcccgggaac gccagcacgt tgttgatctg gttcgggaag 1561 tccgaccgcc ccgtcgcgac gaccgccgcg tacttgtggg cgacctccgg atgcacctcg 1621 gggttcgggt tggccatggc gaacacgaac gcgccctcgg ccatcgaggc caccgccggc 1681 tccggcaccg taccgccgga gacgccgatg aagacgtccg cacccgcgag ggccgcctcc 1741 agcgggccag acagtccggc cttgttggtg aaggaggcca gctcctgctt caccggcgtc 1801 aggtcgtccc ggtcggccga gacgacgccc ttgcggtcgg cgaccgcgac atcgccgatg 1861 ccggcctcca ccagcatctt ggcgatggcg accccggccg cgcccgcgcc cgagatcacc 1921 gcgcgcagct cgcccagcgt ccgcccgctc agccgcgccg cgttccgcag ggcggccagc 1981 gtcacgacgg ccgtgccgtg ctggtcgtcg tggaagaccg ggatgtccag gcgctcctgg 2041 agcttgcgct cgatctcgaa gcaccgcggc gccgagatgt cctccaggtt gacgccgccg 2101 aaggagggcg cgagccggac cacggtctcg acgatctcgt cggcgtccgt gcagttcagg 2161 gcgatcggga ccgcgtccac tccgccgaac tgcttgaaca ggatggcctt gccctccatc 2221 accgggaggg aggcctcggg cccgatgtca ccgagtccca gcaccgccgt gccgtccgtc 2281 acgaccgcga cgaccgacga cttccaggtg tagtcgtgga cgaggtcggg ctgctcggcg 2341 atcgcgctgc acactttcgc gacgccgggc gtgtacgcca gggacaggtc gtccttgtcg 2401 cggatcggca cggtggcctg cacggccatc ttgccgccgc ggtgcagcgc gaacgcgggg 2461 tcgaaggcgt cgagcggctc ggcgccctcc ttctgctccg caccggcttc gctgtcgctg 2521 cgaggattga cgatctccgc tgccactttg tcttacccct taagagttca tggtttgagg 2581 gtttgtccac tcctggtgag gaatgggcgg gcaccgcaca gggagatgac tgtctgggcc 2641 acgtggaccc tgcgcgacgg gcgcgccgca cacgcgccct gagcccctga tgaggggtgt 2701 aaagaacctt cttacccgac ggacgcctcc cgcgacgagt ccgataagcg caagctcaca 2761 tgccggacct cgaacgccgc atgtcggtga catgactcat agccagggtt ttggacaacc 2821 tcccaggccc tcttgacaga cctcggatcg aagacatcgg ccgccctgta cacccgcgat 2881 ccatggcggg ataaggagag attccgcaga tcttccggcc ggaagggcag attcccgcaa 2941 aggttcggtc gtgatgtacc gacctggtgc ggttcggggg ctgacccgtt atccgatttt 3001 gacatgacgg gccccctgaa cggccgagtc cgaatggcaa gatgccgtaa tcacacgagg 3061 tcgcggcact cgaaggtgtg tgctctcgtc gacccacggc accggccggt cccccggccg 3121 gcgtctcgtc aggaactcca ccgtccccat cggcaactcc ctcatccgcc ggaggaacca 3181 ccatgaccgc acgcttcacc cgtcgtacga ccgccgcgca ctcccggcta gcagcggtcg 3241 gtgcgatcgc ggtcgccggc gccctgctgc tcaccggatg cggcgaccag accgagaacg 3301 gcgactccag cggcagcgac aaccagtccg ccgccggcgc tccgctcgcg gacaagctgc 3361 cgcagtcgat ccgcgacaag ggcaccatca aggtcggctc ggacatcgcg tacgcgcccg 3421 tcgaattcaa ggacgactcc ggcaagaccg tcggtatcga cccggacctc gcggacgccc 3481 tgggcaagca gctcggcgtg aagttcgagt tcgagaacgg caccttcgac accctgatca 3541 ccgggctgcg ctccaagcgg tacgacatcg ccatgtccgc gatgaccgac accaaggacc 3601 gccaggaggg catcgactcc gacaccggca agaaggtcgg ccagggcgtc gacttcgtcg 3661 actacttcac cgccggtgtc tcgatctaca ccaagaaggg cgacaaccag ggcatcaaga 3721 cctggtccga cctgtgcggc aagaagctcg tgctccagcg cggcacggtc tccgaggacc 3781 tcgccaaggc cgagaacgag aagtgcccgg ccggcaagaa gatctccatg gaggccttcg 3841 acaacgacca gcaggcccag acccgcctgc gcgcgggcgg cgcggacgcc ggttcctccg 3901 acttcccggt ggcggcgtac gcggtgaaga cctcgggcgg cggcaaggac ttcgaactcg 3961 tcggcgagca ggtcgaggcc gcgccgtacg gcatcgcggt ggccaaggac aacgcgcagc 4021 tgcgtgacgc cctgaaggcg gcgctggacg cggtgatcgc gaacggcgaa tacaagaaga 4081 tcatggacaa gtggggtgtg gcggaaggcg ccgtcaccga ggccgccgtc aacggcggca 4141 agtgaccgcg cggcgggcgc tgaaaggcaa catccgtgac tgttgacatc gacaagacgg 4201 cgggcggccc ggcgggtaac ccgccgaccc cgccggaggc catcaaggcc atcccggtcc 4261 ggcactacgg gcggtacgtc tccgcggtcg tcgcgatcgc gctgctggcc gcggtcgtgt 4321 acgcgttctc gcagggcaag atcaactggg gcgcgatccc ggactacttc ttcgacgacc 4381 gtgtcctgac cggcatgggc aagacgctgc tgatcaccgt cctcgccatg ctgatcggta 4441 tcgtcggcgg catcctgctc gccgtgatgc ggctgtcgaa gaacccggtg acctcgtcca 4501 tcgcgtggtt ctacatctgg ttcttccgcg gcacgccggt cctggtgcag ctggtcgtct 4561 ggttcaacct cggcctggtc ttcgagtaca tcaacctggg cccgttctac cgcgacgagt 4621 ggtcggactt catgacgccg ttcctgacgg cgctgctcgg tctcggcctc aacgaggcgg 4681 cgtacatggc ggagatctgc cgcgccggtc tgctcgcggt cgacgagggc cagacggagg 4741 cggcgcacgc gctgggcatg agccactcca ggacgctgcg ccggatcgtg gtcccgcagg 4801 cgatgcgcgt gatcgtgccg ccgacgggca acgaggtcat caacatgctg aagacgacct 4861 cgctggtgtc ggtcgtccag tacgccgagt tgttcagagt cgcccaggac atcggccaga 4921 cctcgggcgc cccggccgag atgctgttcc tcgcggcggc ctggtacctg ttgctgacct 4981 cggtcttcag cgtcggccag tactacctgg agcgctacta cgcccgcggc tccagccgca 5041 gtctgccgcc gaccccgatg cagaagatca gggcgaacct gttctccctg tcgaaccgct 5101 ccagcacgac gggaggtgcg gcatgaccgc catggtcaag gccgagggcg tccacaagtc 5161 cttcggcgcc gtcgaggtcc tcaagggcat cgacctggag gtggagcagg gcgaggtgtt 5221 ctgcctcatc ggcccctccg gctccggcaa gtccaccttc ctcaggtgta tcaaccacct 5281 cgagaagatc aacgccgggc gtctgtacgt cgacggcgag ctggtcggat accgccagaa 5341 gggcgacagg ctctacgagc tgaaggacag cgaggtcgcc cgcaagcgcc gcgacatcgg 5401 catggtcttc cagcgcttca acctgttccc gcacatgacg gccgtggaga acgtcatgga 5461 ggccccggtc caggtcaagg gcatgagcag gccccaggcc cgggaacgcg cacgggccct 5521 gctggagcgc gtgggcctgg gcgacaaggc cggcaactac ccctcgcagc tctccggcgg 5581 ccagcagcag cgcgtcgcca tcgcccgggc cctggcgatg gacccgaagc tgatgctgtt 5641 cgacgagccg acctccgcgc tcgaccccga actggtcggc gacgtcctcg acgtcatgcg 5701 cgacctcgca gagtccggca tgacgatggt cgtcgtcacc cacgagatgg gcttcgcccg 5761 cgaggtcggc gacagcctgg tcttcatgga cgacggagtg gtggtcgagt cgggcaaccc 5821 gcgcgacgtg ctgaccgacc cgcagcacga ccggacgaag gcattcctgt ccaaggtcct 5881 ctgagaccgc gtgagcagag gtcaggggcg gtacggatct ccgtaccgcc cctcggcgtg 5941 tggtcctact tgaccgccag cagcagggtg tcggacggcg agcaccacac gggccgcgcc 6001 tcgccgaagc ccttctcgcg cagtacgcgc gcgtgccagg ccgccgaggg catgtcgccg 6061 tcggcgtgct cgccgtagat ctcgaagcgg cgggcggtgg gcccggccag caccgggtcc 6121 ttggcggcga gctgccacca ctcggcccag tccagggcgc cctgttcctt ggcggcgtcc 6181 atccgtgcgt gccgctgggc gcgctcggcc gcgttgatcc ggggcgtcgt gtcgtcgatc 6241 atgtggtccg cgttcatgaa gacaccaccg tcgcggacca ggtccgcgac ccggccgtag 6301 agatccgcga gggggtcggc gtgcaaccag tgcagggccg tcgcggtcag cacggcgtcg 6361 tacgagccgt acggcagctt cgacggccag tcggggtcct tgaggtcggc ggtgacgaag 6421 gagacccgct cgtcgcccgc gaaggtgccc tcggcgatgg cgaggagcgc ggggtcgagg 6481 tccaccccgg tgctcgtggc ctgcgggaac cggtcgagca gccgggccgt gatggtgccg 6541 gtgccgcagg ccaggtccag cacgcgcggc gcggtgccga ccagcgcctc gaccatgtcg 6601 agcatgatcc ggaaccgttc ctcgcggtcc ggcatgtacc actcctgctg ccggtcccag 6661 ctctgctgcc aggcctgcca gtcggcaccc gccgcggtgg ccggggtggc ggccggggtg 6721 gcggtcgtcg tggtggtggt cgtgtccgcg ttcgtcatcg agcccctccg tactgcgtcg 6781 cgtaataccc tggaagcacg atcagctgtt acctgaccgc aggcacgacc atagagcccc 6841 tccgtaagga ctacaagtgg aactggccta ttactcggat tacgccgtac gtctcgtcaa 6901 caccgaggaa ccgtcgcgcg ggcaggactc cctgacctcg gtggaggccg tccgtgacct 6961 cttcggcgcc aaccagtcgg cggcccggcg cgcgtccgac gccgacgtga cccggttccg 7021 ctcggtccgg ggacggctgc gcgcggtctt cgaggcggcc gacgggggcg acgagaccct 7081 cgccgtggac ctgctgaact cactgctcct ggagttcccg gtgagcccgc agatctccgg 7141 gcacgaccac cgggcggagg acggcagccc gctgtggcac atgcacctgg cggaccaccc 7201 ctccaacgcg accgccggtt tcgcggccat cgcggcgatg ggcctggcct tccacctcac 7261 cgagtacggg gtggaccggc tgggcctgtg cgaggcggcc ccctgccgca acgcttacct 7321 ggacacctcc accaaccgct cccggcgcta ctgctccgac cgctgcgcca cccgcgccaa 7381 cgtcgcggcc taccgcgccc gcaagcgcct ggaggcggac cggtcggcca gcaccggcct 7441 gaccgccgac agcacccagc ggaccacggc gagcggcgaa cgctgacccg gccgcggcgg 7501 gcggtagcgg aaccggaccc tgcccagcac gaggtcctgc gggaccacgc cgtagtcggt 7561 gctgtccccg cccgcgaacg cgttgtcccc gagcacccac cagccggtcc cgcgccgttc 7621 ggccgcccgt ttgaccacga gcaggtcctg ctggaagggg tgccgcagga cgaccacgtc 7681 acccggccgg acccgcgctc cccagtgcac gagcagcacg tcaccgtggt gcagcgtggg 7741 caccatcgac ggcccggtca cctcggccgg cccgaagggc agcgtccctc tcgcgcgctc 7801 ggtctcctgc gacagttgct ccggcatcac ccggcacctc cccggtcttt cctccaccag 7861 tctcagtctc accccggact tttgtcctaa gcccacgggg gcactcgcga aatcgggtct 7921 cccagggagt aatgtccccc ctgagaagac gatcacgagg aaggaacgct tcatgctttc 7981 ccgcctgttt gcccccaagg tcacggtcag cgcccactgc gacctgccct gcggcgtgta 8041 cgacccggcc caggcccgca tcgaggcgga gtcggtgaag gccgtccagg aaaagatggc 8101 cggcaacgac gacccgcact tccagacgcg cgccacggtc atcaaggagc agcgcgccga 8161 gctcgcgaag caccacgtct ccgtgctgtg gagcgactac ttcaagcccc cgcacttcga 8221 gaagtacccg gagctgcacc agctggtcaa cgacaccctt aaggccctgt cggccgccaa 8281 gggctcgaag gacccggcga ccggccagaa ggcgctggac tacatcgccc agatcgacaa 8341 gatcttctgg gagaccaaga aggcctgacg gacgtcagca tcctgggccg gcgatcggtg 8401 caccatcgca ggccgcagga cagcccgaag gggcccggcc gccatccggc cgggcccctt 8461 cggcgttgcc ggggccagga ggggcccacg gtcggggcct gcccctgacc gcccctcggt 8521 cctgcgggta gctcagcgct tgcggtggta cgtccgcacc acgacgccgt tgccgaaggt 8581 ccgcacggag tccgtcacga actcggagac ggcgaaaccg gaggcgaaca tcggcatgcc 8641 ggtgccgagc accaccgggt agctcttgat gaccagctcg tcgacctcgt cggccagctc 8701 gccggcgacg gccgcgccgc cgcacaggta gatgtcgaag gcactgtcct ccgccttcaa 8761 ctccctgacc ctgcccacca ggtcggtcga gatgatctcg acgttcgggt cgggcgactc 8821 ggtgagcgtg cgggaggcga cgtactcgcg cagatgcgcg tacgggctgg tgacgccctc 8881 cttgagggcc aggtcgtagc tggccctccc ctgcacgatg gtgtcgaacc gcttgttcgg 8941 caggtcgtcg atgcccagcg gcctacggcc gtgggtcggc agcgtctccg ggtactccga 9001 cttcaggaac gcgaagaact cctcgtcgac gaacgggacc atgaacgtgg cgtcgccgtc 9061 cgggccgccg atgaaaccgt cgatcgagca ggcgacgaag tacgtgagtt tgcgcaaacc 9121 ggtctcccct tcatgttgac cactacgatc acagtactcc acccgtagtt gtttggggag 9181 gggattgtcg gggctaccgg gtctgcggct cgcgccacat gggccacatc cgggggccgt 9241 ccggcaggtc cagggcccgg ccggtgaact cgaacccgag gcgctcgtac agcgccttgc 9301 cgcgggcact gctcgcctcg aggtaggcgg gcagcctctc gcggtcgcag cggtcgagca 9361 cgctctcgat cagcgcggtg ccgagaccct cgccctgccg cccggggagc acaccgatca 9421 tccacaggta ctcatgggcc cgcccggtgg ggtggatgcc gtccgtgagc cgggctatca 9481 gctccacgcg ctcgttctcc gggtcgacgg cctcgcggat ctgcgcggga gcgtcctcgg 9541 cggccgtgtg ctcgtccgcc gggacgggca gccacaacgc gcaggcggcg ccgtcctcgg 9601 tgagatcgat gcgtccgtcg gcgaacacgg cgtcggcaaa cgcggccatg agccggtggt 9661 gcgtccggcg ccggtactcc tcaccgggga agacccaact gctcaccgga tcgtcctgga 9721 aggcctcgtc cagcaaccgg acgaccagat cccggtcgtc ctcccccgcc gtccggatca 9781 ccacacccat acctcacccc tccgactcaa caccgctcgt gtgtacggcg gttgagccta 9841 acgggtggcc ccgggccctg acgggggaga caaggaggcg ggccccgcac accgtgggga 9901 agtgcgggac ccgccggacc ggagccgtcg gcggtgcggc cgtacgtcgg tcaggtgccg 9961 tacggccctg cacgggctcc ggggtcttgc gtggcggcgc tcaggtactg cgccgggtca 10021 cgaactcggc cagcgcgagc aggccgccgg ccgcctccgg ttcgggcacg gcacgggcca 10081 gctcctgcat ggccttcgcc atatggtcgg ccgcctgggc ctgcgcccag tcccggccgc 10141 cggcccgctc cacggccagg gcggtgcgct ccaggtcctc cttgccctcg tcgtacggcg 10201 ccgcgtacag ctcggccagt tcggcggcgg ccgtggtgcc ggaggtgagg gcggcgacca 10261 ccggcagtga cttcttgcgg gcggccaggt cggcaccggc cggcttgccg gtgtggcgcg 10321 ggtcgcccca tatgccgatc acgtcgtcga tgagctggaa ggccagcccg gcctcgcggc 10381 cgaaggcgtc cagtgcctcg acgtcctccg tggccgcacc cgcgtacagc gcacccaggg 10441 cacaggcaca gcccagcagg gctcccgtct tggcctcggc catggcaagc gtctcgtcga 10501 gcgtgacctc gcccggcggg cgccgttcca tggccgtgtc cgcgtgctgg ccctcgcaca 10561 gctccatgac gcagtcggcg agccgggcgg ccgccgccgc ggacgcgggg tgcgggtccg 10621 cggcgagcag gcgcagggcg agcgcctgga gggcgtctcc ggcgaggatc gcgtcggcgt 10681 caccgaacac ggtccacgcg gtcggccggt gtcgccgggt ggcgtcccgg tccatcacgt 10741 cgtcgtgcag cagggtgaag ttgtggacca gctccaccgc cgcggcggcc cggccggccg 10801 ccgcgcgggc cgccggcccg ccgagcgcgg tcgccgcggt gaggacgagc gcggggcgga 10861 tcgccttgcc cgcgttgccc gccgcgggcg tgccgtccgc gtgctgccag ccgaagtggt 10921 agagcgcgat ccggcgcatc gactcgggca gcgaagcgat ggcggaccgc agttcggggt 10981 cgaccgatgc ccgtgactcg ctcaggagca cggccgcctc gtgtccttcg gccgcccgtc 11041 ccggaccgtc ggacgactcc gccggctcct tctcgcgctg tgtaccgatg ggcccgtgcc 11101 tttccggtgc tccggtggga cgacgcgtcg cggtgccgcc gcgccgggtc tccgtcatgg 11161 actcaccttc cccctgggcc cgtccgtacc cccggggtgt acccgcccgg gagggcggga 11221 acaccgcgtt cggggctgcg aggtcaccgc cagcggccga tctcgacgtt ctccaggacg 11281 ccgagcgcgt ccggtaccag gacggcggcc gagtagtagg ccgtgaccag gtacttgatg 11341 acggcctgct cattgatgcc catgaagcgc accgacagac tcggctcgat ctcgtccggg 11401 atgccggtgg cgcgcagacc gatgacgccc tggtcctgct cgccggtacg catcgcgatg 11461 atcgacgagg tgcgggcctc ggtgaccgga atcttgttgc acgggtagat gggcacaccg 11521 cgccaggtcg ggatgcggtt cccggcgacg tcgatcgtct ccgggacgag accgcgcttg 11581 ttcagctcgc ggccgatggc ggcgatggca cgcgggtggg cgaggagcag cttggtgccg 11641 cgccggcggc tcagcagctc gtcgaggtcg tccgggccgg gcacgccttc gtgcggctgg 11701 atgcgctggt cgtactcgca gttgtgcagc aggccgaact cgcggttgtt gatgagttcg 11761 tgctcctggc gctccttcag cgcctcgacc gtcaggcgga tctgctgttc ggtctggttc 11821 atcggctggt tgtacaggtc ggccacgcgc gagtggatgc gcagcacggt ctgcgcgacg 11881 ctcagctcgt actcacgggg ccgggcctcg tagtcgacga aggtgtgcgg gatgtccggc 11941 tcgccgctgt gaccggccgc gaggtcgatc tccttctcac cgtgcttgtt ggtgcgctgc 12001 tccgggatcg agcgccgctg ctccaggtgc tcgcgcaggg actccgcccg ctccgcgacc 12061 tgctccacct cctggcgggg cagcaccagc accgtgcagg cggtgaccgt gcgggcggtg 12121 aactcccaga tggcgtcacc gtcgaggagc gcctggtcgc cgaagtaggc gccgtcggcg 12181 aggacgccga gcaccgcgtc gtcgccgtag ggaccggtgc cgatcttctc gatcttgccg 12241 tgcgccagca ggtagacctc gtcggcccgg ccgccgaacg aggcgatgac ctcgccggga 12301 ccgaactccc gctgctcaca gcgctgcgcg agttccgaca gaacctcgtc gtcctcgtac 12361 gaccgcaggg ccggcagctc gcccagctcc gcggggatga cctcgacgcg gtcgccggtc 12421 ttcacgaacg tcacgcgacc gtcgccgacg gcgaaggtca tgcgccggtt gacccggtac 12481 gtgccgccct ggacgtcgat ccaggggagc gagcgcagca gccagcggga gctgatctcc 12541 tgcatctgag gaacggactt ggtggtggtg gccaggttcc gcgcggccgc cgtgccgagg 12601 ctctgctgcg gcctggtctg ctcggtgcgg acctcttcgc ctaccgacat aaggaattgc 12661 cctcccggtc atgccggacg gctgcgcccg gcatcgatgt gcatggacca gccttcctca 12721 cggagcgtgc cggtgctatt acacgaaaga gcgggaatgg atcacttgcg gccggggcag 12781 atatgggggc ttgttcggcg tctcggcgac ttgtccgact cggtccgccc ctgttcgacg 12841 ccactggccg ggacgagatt ggccgaaacg attcgcacac cgaccgagca agtaataggt 12901 gaagctccgg ttcggtacaa gctccgtacg aggcggtcgc gtcgggcggt cgtcgcgcag 12961 cgtgaaggag ccggccgtgg cctcacccat gtccgcgagt agtttcctga aggcactgaa 13021 ggcggagggt ctcaccgtcg tcgaggtggg cgactggcgg gaccacaatc gcaaccacaa 13081 gggcccctgg ggccccgtca acggggtgat gatccaccac accgtgaccc ggggcagcgc 13141 gcggacggtg gagatctgcc gcaaggggca cgagagcctg cccggcccgc tgtgccacgg 13201 tgtcatcacc aaggacggca gggtccatct ggtcggctac ggccgggcca accacgccgg 13261 tctcggcgac gacgacgtcc tgcgggccgt cgtcgcggag aaggcgctgc cccgggacaa 13321 cgaggccaac accgacggca accggcactt ctacggcttc gagtgcgaga acctcggcga 13381 cggcaaggac ccttggcccg ccgcgcagtt ggacgcgatc gagcgggccg ccgcggccgt 13441 gtgccgccac cacggctgga acgagcgctc ggtgatcggc cacctcgagt ggcagcccgg 13501 gaaggtcgac ccgcgcggct tcacgatggc gtcgatgcgg gagcgcatcc gcgaccgcct 13561 gaagtgagag tgatccaggg accggccgga gtgccccgtg gaccgaccgc agcaccttcc 13621 ggaccggtcg gcgccatccg cgcaccgacc gcagcacccc tcgcaccggt ctgcgccatc 13681 cgcgcaccga cggcagcacc ccgcagaaca accagagcgg gcgatccggg gaccggcggc 13741 cgcggcggcc caccgccggg cgcagtggct ctgggaccgg gccgcgggag gtgtgcgccg 13801 ggcggcggcg ggacaatggc cgggtgaccg gcaccgacac ccgcgacctc gccgccctgc 13861 ggccccgtct gccctccccc ctgcacgagg tggccgacgg acggttcgag cggcgcggcg 13921 tccggttgct gctcaagcgg gacgatctga tccaccccga gctggtcggc aacaaatggc 13981 gcaagctggc accggtgctc gccgcggcgg acggccgtac cgtcgtcacg ttcggcggcg 14041 cctactccaa ccacctgcgc gccgcggccg ccgcgggccg gctgctcggg ctgtccaccg 14101 tgggcgtggt ccgcggtcag gagctggccg gccggccgct caacccgtcc ctggcccggt 14161 gcgccgccga cgggatgcgg ctgcacttcg tcgaccgctc gacgtaccgg cgcaagtccg 14221 aaccggagac gctggcggcc ctcctccggg cggtggacgc cgagggcgcc gtcgtcgtcc 14281 ccgagggcgg cagcaacacg gaggcggtcc gcggctgccg cgccctgggc gaggagctgg 14341 gcgagcacgc cgacgtggcc gccctcgcct gcggcaccgg tggcaccctc gccgggctgg 14401 ccgccgggct tccccggggg cggcgggccc tcggcatacc cgtgctcagg ggcggcttcc 14461 tggagggcga catacggcgg ctccaggaac gcgcgttcgg cgggccgcgc ggcacctgga 14521 gcctggacga ccgcttccac cacggcggct acgcccgcac gacaccggcg ctggacgcct 14581 tcgccgagga cttcgaacgc cgccacggcc tccccgtgga gcgcgtctac gtcgccaaga 14641 tgctgtacgc cctgctcgcc ctcaccgagg agggcgcctt cccgcgcggg acggccctgg 14701 cggcggtcgt caccggccgc ccctttccct gagccgcacc ggaccaccgc acgcacgcct 14761 acgcgcccgc gtacgcgtgc acgtacgcgt gcgcgtgctc acgtcgtctc ccggtacgcg 14821 gcggcctcct ccagatccag ccggcgcagc agggtccgga gcatctcgtc gtcgatgtag 14881 cggccgtccc gcagccggac gaagacctcg cgctcggcgc tgatcatctc ccgggagagt 14941 cgccggtagg tgtcgtcgac ggtctcgccg gtgacgggat tgacctggcc gagccgttcc 15001 cagacggcgt tgcgacggcg ttccaggacc atgcggaggc ggtcggcgag cggcgccggc 15061 agcgcgttgc gctcgtcggc caggagctcg tccaggtgca gctccgcggc ccgcgaggcc 15121 tgcgcctgcg cgttggcctc cgccagcgtc tcggcctgca cgtcgtgcgc cgggaacttc 15181 agcaggcgga tcagcggcgg caggctgacg ccctggacga ccaacgtgcc gatgacggtc 15241 gtgaaggtga ggaacaggat gaggttgcgc tcggggaagg gctcgccgcc gtgcacggtg 15301 agcgggatgg agaaggcgat ggccagggac accacgcccc gcatcccggc ccagccgatc 15361 acgaacggac ccttccagga gaggtcgccc tcgcgcgcgc gtacccgtgc cgacagccgg 15421 ggcaggaagg tcgccgggta cacccacacg aaccgcgcca ccgcgaccac caggaacacg 15481 gcgagggcgt accaggcggc gtcgatcccc tcgtactcgc cgaggccctt gaggacgacg 15541 ggcaactgga gtccgatgag ggcgaacacg gccgactcca ggacgaaggc gaccatcttc 15601 cacaccgcct cctcctggag ccgggtggcg aaatcgacct cccacgcgcg gtgccccagg 15661 tagagcgcga cgacgaccac cgcgagcacc cccgaggcgt gcacctgctc ggcgaccgcg 15721 taggcgacga acgggatcag cagggagagc gtgttctgta gcagcgcctc cgtcaggtgg 15781 gtgcgcagcc agtgcagcgg caccatcagg accagtccga cgccgacgcc gcccaccgcg 15841 gcgatcagga actcgccgat cccgccggcc caggtggcgc cctcgccgac ggccgccgcg 15901 agcgccacct tgaaggcggt gatggcggtg gcgtcgttca ccagggactc gccctggagg 15961 atcgtggtga tccgggaggg cagtcccacg cggcgggcga cggccgtggc cgcgaccgcg 16021 tccggcggcg ccaccaccgc gccgagcacc agggccgcgg tcagcggcag gcccggcacg 16081 atgaggtacg cggcgcagcc gacgacgaag gtggcgaaca ggacgtagcc cacggacaac 16141 agcgccacgg gccgtgcctg cgcccgcagg tccaggtacg agctgtcggt ggccgccgtg 16201 tagagcagcg ggggcagcag caggggcagg acgatgtgcg ggtcgagggt gtagtcgggc 16261 acgccgggca cgtagctcac cgccaggccc gccgcgacca gcagcagcgg caccggcacc 16321 ggcacccgcc gtcccgccgc ggcgatcgcg gcgctccccg ccaccagcag cagcagcggc 16381 atcacgtcca ttgtcctcgc ccgccctcgt cttccgcgcg gtcatccgca cacccgtcgt 16441 aacctggcaa tcatgaaaca gtgcacgcac gccgacgcgc tgccgcaccc ggaacccgag 16501 ccgtgcggcg agacctgtcc ggagtgcctg gccgagggca cggatccggt gcagctgagg 16561 ctgtgtctca gctgcggcca tgtcggctgc tgcgactcct cgccgaggca gcacgcgacg 16621 gcgcattaca aggagaccgg tcacccggtg atgcggacct tcgagcccgg ggagagctgg 16681 cgctggtgct tcgtcgatca cgtcctcgtg tgacctctgc ccgggacggt tcgaccgtct 16741 gacgtctggg tacgtcaacc cggcgcgcgc tcttccgatt tgagcccgcc gaccccctag 16801 ccactgtgcg tgttcgcgtg tttactatga gtgacagcat gggcttgggg tctcggggac 16861 aggaaacttc ggagcgcgat aacgtcaccg ctgaaccacg tatcgcgtta acccgagggg 16921 cgtccctcgg ccctgtaacg cttgtaccac cttggaggtg agggtgtccc agatcgcagg 16981 cgagcccgcg acccaggact tcgtcgaagt ccggctgccg gccgcgggtg cctacctgtc 17041 ggtgctgcgt acggcgacgg ccggcctcgc agctcgtttg gacttcaccc tcgacgagat 17101 cgaggacctg cgcatcgcag tcgacgaggc ctgcgcgatc ctgcttcagc aggccgtgcc 17161 cggctcggtg ctcagttgtg tcttccgcct cgtcgacgac tcgctcgagg tcaccgtctc 17221 ggcgccgacc acggacggcc acgccccttc gcgggacacc ttcgcctgga cggtgctctc 17281 cgccctcgcg ggcaaggtct cctccgccgt ggacgaggac aaaaccgttt cgatcagcct 17341 ctacaaacag cgcggcgcgg gacccgggcc ggcgtgaggg acggggacgg gccggtgcgg 17401 gacgaagagc gcgggacacg ggagctgccg gccgagggca cacgttctcc gaacgaggca 17461 cggcgcacgg cggacggcat cgacggcatt cccgagcagg cccggccgca tccggaggac 17521 gagacctcgc ccgaggccgt cgttccgggc gacgggcagc ggaccgggga cacccccgtc 17581 cgtcccgtcc gagcggaggc gggggctcgg gaaagggcaa cgggcgggac gatgagcgag 17641 cacgagcgac actccgaggg gcaggcgccg ggcgcacggg gcgcgcaggg cacacggcac 17701 gacccgcagg accgcagcgg tgcgcgcctc ctcttcgccg agctgcgcac gctgacgaag 17761 gacagtccgg agtacgcgga gctgcgcaat cggctggtcc gcatgcacct gccgctggtc 17821 gagcacctcg cgcggcgctt ccgcaaccgc ggcgaaccgc tggacgacct cacccaggtc 17881 gccaccatcg gactgatcaa gtcggtggac cgcttcgacc cggaccgcgg agtggagttc 17941 tccacgtacg cgaccccgac ggtcgtcggc gagatcaagc ggcacttccg ggacaagggc 18001 tgggcggtgc gcgtcccgcg ccggctccag gagctgcggc tggccctgac gacggccacg 18061 gcggagctgt cgcagctgca cggccgctcc cccacggtcc acgagctggc cgagaagctg 18121 tcgatctcgg aggaggaggt cctggagggc ctggagtcgg ccaacgcgta ctccacgctg 18181 tccctggacg tcccggacac cgacgacgag tccccggcgg tcgccgacac cctcggcgcc 18241 gaggacgagg ccctcgaagg ggtcgagtac cgggagtccc tcaagccgct cctcgaagac 18301 ctgcccccgc gcgagaagcg catcctgctc ctgcgcttct tcggcaacat gacccagtcc 18361 cagatcgcgc aggaggtcgg gatctcacag atgcacgtct cccggctgct ggcccgcaca 18421 ctggcacagc tgcgggagaa gctcctggtc gaggagtagc cgccgggtcg ggcgcggcct 18481 gggcgccgcc gtccggcacc cccggggcta cttctcggcg ctgccgggcc cccggatgcc 18541 gagggcctgg gtggtcgtgg gattgacgag cagcaccagc gcggtgacgg ccacgacacc 18601 gagcacgatg ccggccggga cggccaggct gtcggcgcgc accatgttgt aggcgacggg 18661 cagcgccatg atctgtgtga tcacggcggg cccacggctc cagcccttcc ggccgatcag 18721 tccgcgggcg gcgagcagcg gcagcagggc gagcacgatc agggtgacgc cgccggtgac 18781 ggccgaggtc cggtcgtcgg ggtgcccggt gaggccctcc acgagcatcc aggcaccgcc 18841 gacgacgagc gccagccctt ccagcgcggc gagcgcggcc gcggcggtca gccgcccggg 18901 gcggggatcc gccgcttcgg cacgggcatc ggcgtcggcg gccgcggagg cgggggtggt 18961 gggggtctgc tcactgctca cccctgaagg gtagccctcg gcccgtacgc gcccgcccgg 19021 gtgtcgggcg tatcacgcac ccggtgcgcc ggtggcgatc ttcacatcgg tctgggccga 19081 gtaccaccca gtaggtaccc tgcacagcat gcgtgcactt ctcgtggtca acccggcggc 19141 aaccaccacg agcgcgcgca cgcgcgacgt gctgatccac gcgctcgcga gcgagatgaa 19201 gctggaagcg gtcacgaccg agtaccgcgg ccacgcgcgc gacctcggcc ggcaggcggc 19261 gcagagcgac gacatcgacc tggtggtggc cctcggcggc gacggcacgg tgaacgaggt 19321 cgtcaacggt ctgctgcacg cgggtcccga ccccgagcac ctgcccggtc tcgcggtggt 19381 ccccggcggt tccaccaacg tcttcgcccg cgccctcggc ctgcccaacc acgcggtgga 19441 ggccaccggc gccctgctgg acgccctgcg tgagggcagc gagcggaccg tcggcctggg 19501 cctcgcgtcg ggtacgccgg gctcggagga cgagggggtg ccggcccgct ggttcacctt 19561 caacgccggt ctgggcttcg acgccggcgt ggtcggccgc gtcgagcagc accgcgagcg 19621 gggcaagaag tcgacgcacg ccctctacgt ccgccaggtg gtgcgccagc tcatcggcga 19681 gccgcaccgc cgcagcggga cgatcaccct ggagcgggcg ggcgaggacc cggtcaccga 19741 tctggtgctg tccatagttt cgaacacctg cccctggacg ttcctcggca accgcccgat 19801 ctacgcctct cccgaagcct cgttcgacac cgcgctcgac gtcttcgggc tcagccggct 19861 gtcgacggcc gcggttgccc ggtatggcac ccagttgctc acttcgtccc ccgagcgcgg 19921 gccgcgcggc cggcacgcgg tctccctgca cgacctgacc gacttcacct tgcattcgaa 19981 ggtgcctctg ccccttcaga tggacggtga ccacctcggg ttgcgtacca gcgtggcgtt 20041 cacaggcgta cgccgtgcac tgcgtgtgat tgtgtgagca gaaggggcga aagtcctttc 20101 actcgaacgt ttagaccagg gtccacccca tggaagtacg gctgtgacct agtcgacacc 20161 gaagaatcaa aaaaaacttt ccggaagggg ttgtatccgc cgccgaggtt tgcgagtctc 20221 ttcttggcga tcgggacagc ccgcaggacc ggcatccaca gatcaccgga acccctcttc 20281 aaaccacagg accacgccag ggaacctggc ggtaggccct tcccttgttg agggattcgt 20341 gaaagcgttc acattcacaa gcatcccagc atgtaatacc aaggagaggt agcagccatg 20401 gactggcgtc accgcgccgt ttgccgcgag gaagaccccg agctcttctt ccccatcggc 20461 aacaccggtc ccgcgctgct gcagatcgag gaagccaagg ccgtctgccg tcgctgcccc 20521 gtcatggagc agtgcctgca gtgggcgctc gagtccggcc aggactccgg cgtctggggt 20581 ggtctcagcg aggacgagcg ccgcgcaatg aagcgccgtg ccgcccgcaa ccgggctcgt 20641 caggcctccg cctgacaacc cacccctact gacagcctca gcttggcggc gcgtacagcg 20701 agtacgcatc ccccgctccc gagccgcagc gcgcagtacc ccccgatgcg catcggacga 20761 tgtatcgcac gagcactggc ctcggacctt caccggtccg gggctttttg ctgtgcccac 20821 gccccggtcc cgttgcgcgc cgttacttct cggcgggcac cgggatgtcg aggatgaccc 20881 gggtgccgcg ctccgaggcg gggaccatgt cgaaggtgcc gcccagctcg ccctccacca 20941 gggtgcggac gatctgcagg ccgagattgc cggagcggtg cgggtcgaag tcctcgggca 21001 ggccgacgcc gtcgtcctgg acggtgacca gcagccgggc ctccttcgtc gtaccgccgc 21061 ggaccgcgga gacctcgacc gtgccggtgt cgccgtcccg gaagccgtgc tccagggcgt 21121 tctgcaacac ctcggtgagg accatcgaca gcggggtg //