LOCUS NZ_KZ195574 12910 bp DNA linear CON 06-SEP-2024 DEFINITION Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence. ACCESSION NZ_KZ195574 VERSION NZ_KZ195574.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. CS113 ORGANISM Streptomyces sp. CS113 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C., Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines JOURNAL Front Microbiol 9, 39 (2018) PUBMED 29441046 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for glycosylated natural products in actinomycetes isolated from leaf-cutting ants: activation of two silent clusters and identification of a novel macrolactam JOURNAL Unpublished REFERENCE 3 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Direct Submission JOURNAL Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia, Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006, Spain COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.9 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 78.17x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_002188365.1-RS_2024_09_06 Annotation Date :: 09/06/2024 02:31:13 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,790 CDSs (total) :: 7,719 Genes (coding) :: 7,614 CDSs (with protein) :: 7,614 Genes (RNA) :: 71 rRNAs :: 2, 1 (5S, 16S) complete rRNAs :: 2 (5S) partial rRNAs :: 1 (16S) tRNAs :: 65 ncRNAs :: 3 Pseudo Genes (total) :: 105 CDSs (without protein) :: 105 Pseudo Genes (ambiguous residues) :: 0 of 105 Pseudo Genes (frameshifted) :: 35 of 105 Pseudo Genes (incomplete) :: 81 of 105 Pseudo Genes (internal stop) :: 4 of 105 Pseudo Genes (multiple problems) :: 15 of 105 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 09:56:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 1728973 Orig. end :: 1741883 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to KZ195574.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Prof. Salas's laboratory, A. Microbiology, University of Oviedo, Spain. FEATURES Location/Qualifiers region 1..12910 /candidate_cluster_numbers="1" /contig_edge="False" /product="hydrogen-cyanide" /region_number="10" /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)" /tool="antismash" cand_cluster 1..12910 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)" /kind="single" /product="hydrogen-cyanide" /protoclusters="1" /tool="antismash" protocluster 1..12910 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[5000:7910](-)" /cutoff="5000" /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)" /neighbourhood="5000" /product="hydrogen-cyanide" /protocluster_number="1" /tool="antismash" proto_core complement(5001..7910) /aStool="rule-based-clusters" /tool="antismash" /cutoff="5000" /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)" /neighbourhood="5000" /product="hydrogen-cyanide" /protocluster_number="1" gene complement(409..2244) /locus_tag="B9W62_RS07465" /old_locus_tag="B9W62_07480" CDS complement(409..2244) /EC_number="7.-.-.-" /GO_component="GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1288: ABC transporter related protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009316421.1" /locus_tag="B9W62_RS07465" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07480" /product="ABC transporter ATP-binding protein" /protein_id="WP_087806367.1" /transl_table=11 /translation="MGTTDTRGPAPGRSAVVLALRHYGRELLRLRRLALPALLLPAVGN IGIRYVAPLLIAKLAGQAAEGDGLALGPALPYVLGFGVTLLLAEALWRIGQHCLNRVDA LGMEHLYVSGMDELLAKDAAFFHDNFAGSLTKRVLSYGKRFEDFVDTVTYRIVGSLVPL VFGAVVLWSYEPMLVVGLFVMIALTVAAATPLIRRRQRLVNEREAAIARVSGHVADSLM NMETIRAFAAERREAGEHRSRVADSRRLTLKSWDYGNLRVDTLIAPMSVLTNVLGLLVA LAFGGPGQGVEEVVVAFTYYSNATQIMFEFNQIYRRLESSMTEAAQFTELLLDPPTVLD ADAPEPLAPRDTGIRFEAVTFAHTGAKPIFQGLDLDVPAGARIGLVGRSGGGKTTLTRL LLRMSGLDRGRILIGGQDISRLRQSDLRSLIAYVPQEPAMFHRSLRDNIAFARPGATDE EIHAAAEAAHVTEFAGQLPDGFGTLVGERGVKLSGGQRQRVALARALLRDAPVLLLDEA TSALDSESELLVQDALWRLMDGRTALVVAHRLSTVAGMDRLVVLDRGRVVEQGSHQELL ATDGAYARLWQHQSGGFLGENTGTESEAALERPVA" misc_feature complement(2363..2379) /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 16.35" /tool="antismash" misc_feature complement(2365..2375) /note="TFBS match to HypR, L-hydroxyproline utilization repressor, confidence: weak, score: 20.42" /tool="antismash" gene 2415..3128 /locus_tag="B9W62_RS07470" /old_locus_tag="B9W62_07485" CDS 2415..3128 /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1071: GntR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019330889.1" /locus_tag="B9W62_RS07470" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07485" /product="GntR family transcriptional regulator" /protein_id="WP_087806369.1" /transl_table=11 /translation="MPHLSSQAISVQTHLRDQVADALRAALIAGDLRPGVVYSAPTLAA ELGVSATPVREAMLDLAREGLVEAVRNKGFRITEMTERDLDEFTEIRTLIEVPTVGRVT ATATAGQLEALRPLAEQIVTAAREHDVLKYLEADHRFHLELLALAGNHHLVAVVADLRK RSRLFGLGSLNETGRLVASAQEHVELLDLMVAGRTREAEECMRRHLTHVRTLWADGAAD TGDAPGAAQSVKPAG" gene complement(3104..4105) /locus_tag="B9W62_RS07475" /old_locus_tag="B9W62_07490" CDS complement(3104..4105) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019891275.1" /locus_tag="B9W62_RS07475" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07490" /product="proline racemase family protein" /protein_id="WP_087806371.1" /transl_table=11 /translation="MRSTVCYHAVDSHTEGMPTRVITGGVGVLPGATMFEKRQRFVAER DHLRTLLMCEPRGHASMSGAILQPPTRPDADYGVLFIEVSGCLPMCGHGTIGVATVLVE TGMVEVTEPETLVRLDTPAGLVTARVRVREGHAESVTLENVASYSHALDQVVDVPGYGE VRYDIAYGGNFYAFVRTDDLGIPFERAHKQRLLDAGLAVMDAVNKQNPVSHPENPEIDV CHHVYLEAPGSTAEHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLPAGRDFVNES FIGSRFVGRVLGETTVGDRPAVLPSVTGRAWITGTAQYLLDPSDPYPAGFTL" gene complement(4108..5004) /locus_tag="B9W62_RS07480" /old_locus_tag="B9W62_07495" CDS complement(4108..5004) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030799.1" /locus_tag="B9W62_RS07480" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07495" /product="dihydrodipicolinate synthase family protein" /protein_id="WP_087806373.1" /transl_table=11 /translation="MSETRKPWHGVIVATGLPFHDDLSVDFAAYGESVAHLAEQGMHGV APNGSLGEYQTLTYEERDRVVETAVANAPEGFTVMPGVGAYGGREAERHARFAKDAGCQ AVMCLPPNAYRADDRAVLEHFERVASVGLPVTAYNNPIDTKVDLRPDLLAKLHAEGFVV GVKEFSGDVRRCYEISELAPGLDLMIGTDDTVLEVALAGAKGWVAGYPQVFPRACLALY EASVRGDLETALPLYRQLHPVLRWDSKTEFVQAIKLGQEMTGRRGGVCRPPRQPLAPET EAVVRAATQALIDAGVN" gene complement(5001..6500) /locus_tag="B9W62_RS07485" /old_locus_tag="B9W62_07500" CDS complement(5001..6500) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) hydrogen-cyanide: Pyr_redox_2" /gene_functions="biosynthetic (rule-based-clusters) hydrogen-cyanide: Fer2_BFD" /gene_functions="biosynthetic-additional (smcogs) SMCOG1176: alkyl hydroperoxide reductase subunit" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030798.1" /locus_tag="B9W62_RS07485" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07500" /product="NAD(P)/FAD-dependent oxidoreductase" /protein_id="WP_256976224.1" /sec_met_domain="Pyr_redox_2 (E-value: 2e-17, bitscore: 62.2, seeds: 64, tool: rule-based-clusters)" /sec_met_domain="Fer2_BFD (E-value: 1.1e-11, bitscore: 43.8, seeds: 211, tool: rule-based-clusters)" /transl_table=11 /translation="MTDPADLIVVGAGPAGLAAAATALAGGLRVVLLDSGTALGGQYWR HPPEHARAAVPTDDLHHGLDRYRALCKALAAHRTSGRLDLRLEHHVWSAVRDGDGFAVH AVDRHEAPRETAVVLRAPRLLVATGAYDRPLPFPGWDLPGVLTVGGLQALLKGGSVAAG SRVALGGTGPFLLPVAAGLAARGVEVVEVCEAAHPRAWLRHPGPLLRNPGKWAEGAGYA AALVRHRVPLRPRTAIVAAEGGARVTAVRIASLAPDGSPRPGTGRRVEVDAVGVGWGFA PQLDLLVPLGCALTEAADGNAAVAVDEGQRTTVPGLYTAGETCGVGGAALAVNEGRLAA ASVLADSRATRVPANKHLTALRSAVERQRAFARAMALAHPLPPAWSSWLTDETVVCRCE EVTAGTVRSAHADGAHDHRQVKQLTRAGMGWCQGRMCGPAVHCLTARRRAYEPAERLVA TPVTLGALADLDEVPPTPQVPQALPTPQASTANGVTDKECS" gene complement(6493..6747) /locus_tag="B9W62_RS07490" /old_locus_tag="B9W62_07505" CDS complement(6493..6747) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) hydrogen-cyanide: Fer2_4" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003972635.1" /locus_tag="B9W62_RS07490" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07505" /product="(2Fe-2S)-binding protein" /protein_id="WP_087806375.1" /sec_met_domain="Fer2_4 (E-value: 8.4e-25, bitscore: 85.5, seeds: 114, tool: rule-based-clusters)" /transl_table=11 /translation="MTEMIVDGRPLPFVEGQTVAAALVATGRLAWRTTRVGHRPRGVFC GIGVCFDCLVTVDGAPGQRACLVPARPGMTVTTGEGDDD" gene complement(6744..7910) /locus_tag="B9W62_RS07495" /old_locus_tag="B9W62_07510" CDS complement(6744..7910) /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) hydrogen-cyanide: DAO" /gene_functions="biosynthetic-additional (rule-based-clusters) Trp_halogenase" /gene_functions="biosynthetic-additional (smcogs) SMCOG1103: FAD dependent oxidoreductase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003972636.1" /locus_tag="B9W62_RS07495" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_07510" /product="FAD-binding oxidoreductase" /protein_id="WP_087806377.1" /sec_met_domain="DAO (E-value: 6.8e-68, bitscore: 228.6, seeds: 521, tool: rule-based-clusters)" /sec_met_domain="Trp_halogenase (E-value: 4.6e-05, bitscore: 21.2, seeds: 23, tool: rule-based-clusters)" /transl_table=11 /translation="MTRKVVVVGAGVVGAACAFHAASAGLDVTVTDRGPVGAGTTSRGE GNVLLSDKEPGPELALARLSRTLWDEAGQELGPDTLELEPKGGLVVASGAENLATLREF AARQEAAGVRVERVDRVRDLEPHLAPDIPGGVHYPQDAQVQPVLAAAALLRAALRRGAR FHQGEVAGAVTGRDGRVTGVRTAAGDVLPADAVVNAAGTWGGEVGRRLGAPVEVLPRRG FVLVTEPLPPMVRHKVYSADYVANVASSDAGLETSCVVEGTRGGTVLIGASRERVGFDT TMNTAVVARLAAQACRLFPFLRGVHLMRAYRGFRPYCPDHLPVVGPDPRVPGVVHACGH EGAGVGLAPGTGALVTAHLLGRPWRGADPAAHSGLLPDRFLTPGGVPQ" misc_feature 7940..7950 /note="TFBS match to HypR, L-hydroxyproline utilization repressor, confidence: strong, score: 22.4" /tool="antismash" gene complement(8033..10228) /locus_tag="B9W62_RS40635" CDS complement(8033..10228) /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003994025.1" /locus_tag="B9W62_RS40635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="SWIM zinc finger family protein" /protein_id="WP_256976225.1" /transl_table=11 /translation="MAREALRAARRQAKADAASEGGSANSAAPARRSSRPAGGQRPARG PATADARARAVRDFAAGAFRLPPEEDPAEEALPAGESAGGPVAEVREVARRGSGSSPGG DRAAARAVRGFAAGAFRLPPEEDPAEEALPAGESAGGPVAEVREVARRGSGSSPGGDRA VRGSFAGAFRLPPEEDPAEEAPPARESAEGSATEGSATGSSASEGPAAAHPAPEPSPGA DHSAGATGAERSAGFAADGGHVGGSADDGRTTGGALAPARAGHASRSEGAGSVAEWSRR SQQQQQPAAARGRDGSVSAAQPRAPRSMAAPDRDGDLRRTFAALPPREAADEGFAGTWW GNAWVTALEEGALDAARLERGRGYAERGHVDAITVTPGLVLGYVQGSRARPYRVQVRLR TLGDADWDRFLDAAVERPGHIAALLDKELPHSLADLADRGVPLLPGPGDLTPQCSCPDS GHPCKHAAALCYQTARLLDADPFVLLLLRGRGERALLDALSRRNAARAARAAQDRGPAP LPGVRAGAALTPRALPPLPPPLPAPPHPEQPPAYPGAPGGPDPFALDQLATDAAARAHA LLTTGRDPVGGLTLWQDAVRLAAARPGSGLTAGTRALYASLASAAGRDTAELARAVAAW RQGGPEGLDVLEEPWDPPAGRFDRARPLLLAADLPAFRPWRNRLTHPRGHVQLRLGRAG LWYAYESEPGREDWWPRGTPDLDPVGALTGLGTRVDL" misc_feature 10938..10952 /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: strong, score: 20.47" /tool="antismash" misc_feature 12044..12059 /note="TFBS match to ClgR, Caseinolytic protease gene regulator, confidence: weak, score: 23.56" /tool="antismash" misc_feature complement(12251..12264) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.47" /tool="antismash" ORIGIN 1 gacgggagcc cgacgccgcg aagatcgacg aggccgtggc cgccgcacgg ggccgggacg 61 cggtggtcgt caccaccgac aacgtcggcc ccaccagtgc ccagcgcacc ctggtgtccc 121 ggctggtcgc gacgggcgtc cccgtcgtcc acctcgcggt gcgcaacccc tacgacatcg 181 cccacctcgg cgacgtcccg gcctcactgg cctcctactg ctggaccgag gtcgaactgc 241 gcgccgccgc aagggtgatc gcgggccggg tcgatccgcg cggacgactg cccgtgcccg 301 tccagcgggc cgacgacccg gcccgggtcc tcttcccgtc cgggcacggc ctgtcgtacg 361 acgactgacg cggccgcccg ctccgtcacg tccgtgaccg cgggcccgtc aggcgaccgg 421 gcgttccagg gccgcctccg actcggtccc ggtgttctcg ccgaggaagc cgccggactg 481 gtgctgccag agtctggcgt aggcaccgtc cgtcgcgagc agttcctggt ggctgccctg 541 ctcgacgacg cgcccgcggt cgaggacgac gagccggtcc atgccggcga cggtgctcag 601 ccggtgggcg accaccaggg ccgtgcggcc gtccatcaac cgccacaggg cgtcctggac 661 gaggagttcg ctctccgagt ccagcgcgct ggtcgcctca tcgagcagca gtaccggggc 721 gtcgcgcagg agggccctgg cgagggcgac gcgctggcgc tgcccgccgg acagcttcac 781 ccctctctcc ccgaccagcg tgccgaagcc gtcggggagt tgaccggcga actccgtgac 841 gtgcgcggcc tcggcggccg cgtggatctc ctcgtcggtg gcgcccggcc gggcgaaggc 901 gatgttgtcc cgcaggctgc ggtggaacat ggcgggttcc tgcgggacgt aggcgatcag 961 cgagcgcagg tccgactggc gcagccggct gatgtcctga ccgccgatca ggatgcgtcc 1021 gcggtcgagg ccggacatcc gcagcaggag ccgggtgagc gtggtcttgc cgccgcccga 1081 cctgccgacc aggccgatcc gggcgcccgc gggcacgtcg aggtcgagtc cctggaagat 1141 cggcttcgca ccggtgtggg cgaaggtcac cgcctcgaag cggatgccgg tgtcccgcgg 1201 tgcgaggggt tcgggcgcgt cggcgtcgag caccgtgggc gggtccagca gcagctccgt 1261 gaactgggcc gcttcggtca tcgagctttc cagccgccgg tagatctggt tgaactcgaa 1321 catgatctgg gtggcgttgg agtagtaggt gaaggcgacg acgacctcct ccactccctg 1381 accgggaccg ccgaaggcga gggcgaccag caggcccagc acgttggtca gtacggacat 1441 gggcgcgatc agggtgtcga cgcgcaggtt gccgtagtcc caggacttca gggtcaggcg 1501 ccgggagtcc gcgacccggc tgcggtgttc gccggcctcg cgccgttcgg ccgcgaaggc 1561 ccggatggtc tccatgttca tgaggctgtc ggcgacatgg ccggagaccc gggcgatcgc 1621 ggcctcccgt tcgttgacga gccgttgcct gcgccggatc agcggcgtcg cggccgccac 1681 cgtcagcgcg atcatcacga acaggccgac gacgagcatc ggttcgtagc tccacagcac 1741 cacggcaccg aagaccaggg gcacgagact gcccacgatc cggtacgtca cggtgtcgac 1801 gaagtcctcg aagcgcttgc cgtagctgag gacccgcttg gtgagggagc cggcgaagtt 1861 gtcgtggaag aacgcggcgt ccttggcgag gagttcgtcc atgccgctca cgtacaggtg 1921 ctccatgccg agggcgtcca cccggttcag gcagtgctgc ccgatccgcc acagggcctc 1981 ggcgagcagc agcgtcacac cgaagcccag cacgtacggc agagccgggc cgagggcgag 2041 accgtcaccc tcggcggcct gcccggccaa cttggcgatc agcagggggg cgacgtagcg 2101 gatgccgatg ttgcccacgg ccggcagcag cagcgcgggc agggccagtc gtcgcagtcg 2161 cagcagttcc cggccgtagt ggcgcagcgc caggacgacc gcgctcctgc ccggcgccgg 2221 ccctcgcgtg tctgttgtcc ccatcacact cccggaggtt cggaagcggg aagtctcccg 2281 tcggacaggg gtcacggtcc aggcaattac cgcgcaccgt cgataaccgg acatcgtgga 2341 gtcaacccgg acggcctacg caacgtgaca ttgtatagtg agggatcgtt ggctggacgg 2401 acgcaggagc acggatgccg cacctctctt cacaggcgat ctccgtccag acccatctgc 2461 gcgatcaggt cgccgacgcg ctgcgggccg ccctcatcgc cggcgacctg cgaccgggtg 2521 tcgtctactc cgcccccacc ctcgccgcgg aactgggcgt ctccgccact ccggtgcgcg 2581 aggccatgct ggacctggcc cgggaggggc tggtcgaggc ggtgcgcaac aagggtttcc 2641 ggatcaccga gatgaccgag cgggacctcg acgagttcac cgagatccgg accctgatcg 2701 aggttcccac cgtgggacgc gtcaccgcga cggcgaccgc cgggcagttg gaggcgctgc 2761 gcccgctggc ggagcagatc gtcaccgcgg cccgggagca cgacgtcctc aagtacctcg 2821 aggccgatca ccggttccat ctcgaactgc tggcgctggc cggcaaccac cacctcgtgg 2881 cggtggtggc cgacctgcgc aagcgttcac gcctgttcgg tctgggctcc ctgaacgaga 2941 ccgggcggct ggtcgcgtcc gcgcaggagc acgtcgagct gctggacctg atggtggccg 3001 gccggacccg cgaggccgag gagtgcatgc gccgccatct cacccacgtc cgcacgctgt 3061 gggcggacgg cgcggcggac accggcgacg cacccggggc ggctcagagc gtgaaacccg 3121 ccgggtaggg gtcggagggg tcgagcaggt actgcgcggt gccggtgatc caggcgcggc 3181 cggtgacgga cggcaggacg gccgggcggt cgcccaccgt cgtctccccc aggacccggc 3241 cgacgaaccg ggagccgatg aaggactcgt tgacgaagtc ccgccccgcc gggagcagac 3301 cgcgggcgtg cagctgcgcc atccgcgcgc tggtgccggt gccgcagggc gacctgtcga 3361 accatcccgg atggatcgcc atggcgtgcc gtgagtgctc ggcggtcgat ccgggagcct 3421 cgaggtagac gtggtggcac acgtcgatct ccggattctc cgggtgggac accgggttct 3481 gcttgttgac cgcgtccatg acggccagcc cggcgtcgag cagccgctgc ttgtgcgccc 3541 gctcgaaggg gatgccgagg tcgtcggtgc ggacgaaggc gtagaagttg ccgccgtagg 3601 cgatgtcgta gcgcacttcc ccgtacccgg ggacgtcgac gacctggtcg agtgcgtggc 3661 tgtacgaggc gacgttctcc agggtcaccg actccgcgtg gccctcgcgc acccgcaccc 3721 gggccgtgac cagtcccgcc ggggtgtcga gccgtaccag ggtctccggc tcggtcacct 3781 cgaccatgcc ggtctcgacg aggaccgtcg cgaccccgat ggtgccgtgc ccgcacatcg 3841 gcaggcagcc ggagacctcg atgaacagga cgccgtagtc ggcgtcgggc cgggtgggcg 3901 gctggaggat ggccccggac atcgaggcgt ggccgcgcgg ttcgcacatg agcagggtgc 3961 gcaggtggtc gcgttcggcg acgaaccgct gccgcttctc gaacatcgtc gcgccgggca 4021 ggacgcccac cccgcccgtg atcacgcggg tgggcatgcc ctcggtgtgc gagtcgacgg 4081 cgtggtagca gaccgtcgag cgcatcgtca gttcaccccc gcgtcgatca gggcctgggt 4141 ggcggcgcgc acgacggcct ccgtctcggg agccagcggc tgtcgcggcg ggcggcagac 4201 accaccgcgg cggccggtca tctcctggcc gagcttgatg gcctggacga actccgtctt 4261 gctgtcccag cgcagcaccg ggtgcagttg gcggtagagc ggcagcgccg tctccagatc 4321 gccccggacg gacgcctcgt acagcgcgag acaggcccgg gggaagacct gcgggtaccc 4381 ggcgacccag cccttggcgc cggcgagggc gacctcgagg acggtgtcgt cggtgccgat 4441 catgaggtcg aggccggggg ccagctcgga gatctcgtag cagcgccgga cgtcgccgga 4501 gaactccttg accccgacga cgaacccctc ggcgtggagc ttcgccagca ggtcggggcg 4561 caggtccacc ttggtgtcga tggggttgtt gtacgcggtg acgggcaggc ccaccgacgc 4621 cacccgctcg aagtgttcga gcaccgcgcg gtcgtcggcg cggtaggcgt tgggcggcag 4681 gcacatgacg gcctggcagc ccgcgtcctt ggcgaacctg gcgtgccgct cggcctcccg 4741 gccgccgtac gcgccgacgc ccggcatcac ggtgaacccc tcgggtgcgt tcgcgacggc 4801 ggtctcgacg acgcggtcgc gctcctcgta cgtgagggtc tggtactcgc ccagcgaccc 4861 gttcggtgcg acgccgtgca tcccctgctc ggcgaggtgg gcgacgctct cgccgtaggc 4921 cgcgaagtcg accgagaggt cgtcgtggaa cggcaggccg gtcgcgacga tgacgccgtg 4981 ccagggcttg cgggtctcgc tcatgaacac tccttgtcgg tcacaccgtt ggccgtcgac 5041 gcctgcggtg tcggcagtgc ctgcggtact tgaggtgtcg gcggtacttc gtcgaggtcg 5101 gcgagcgccc cgagggtgac gggcgtcgcg acgagccgtt ccgcgggctc gtaggcccgc 5161 cgccgtgccg tgaggcagtg cacggcgggc ccgcacatcc ggccctggca ccagcccatc 5221 ccggcccggg tcagctgctt gacctgccgg tggtcgtgtg cgccgtcggc gtgggcgctg 5281 cggaccgtcc cggcggtcac ctcctcacag cggcacacga ccgtctcgtc ggtcagccac 5341 gaggaccagg cgggaggaag cggatgggcc agggccatgg cccgggcgaa ggcacgctgt 5401 cgctccaccg ccgaacgcag ggcggtcagg tgcttgttcg ccggtacgcg agtggcgcgc 5461 gagtcggcga ggacggacgc cgcggccagc cggccctcgt tcacggcgag cgccgccccg 5521 cccactccac acgtctcgcc cgcggtgtag aggccgggga cggtggtgcg ctggccctcg 5581 tcgaccgcga ccgccgcgtt gccgtcggcc gcctcggtga gggcgcagcc gagggggacg 5641 agcaggtcga gctggggcgc gaaaccccag ccgacgccga cggcgtcgac ctcgacgcgt 5701 cgtcccgtgc ccggccgcgg gctgccgtcc ggcgccagcg aggcgatccg taccgcggtc 5761 acgcgtgcgc cgccctccgc ggcgacgatc gccgtgcgcg ggcgcagggg gacgcggtgg 5821 cgtacgagtg cggcggcgta cccggcgccc tcggcccact tgccggggtt gcgcagcagc 5881 gggccggggt gtcgcagcca cgcccgcggg tgggccgcct cgcacacctc gacgacctcg 5941 acgccgcgcg ccgcgagacc ggcggcgacc ggcagcagga acgggccggt gccgcccagc 6001 gccacgcggc ttccggccgc cactgagccg cccttgagca gcgcctgtag tccgccgacg 6061 gtcagcaccc cgggaaggtc ccagcccggg aagggcagtg ggcggtcgta ggcgccggtg 6121 gcgaccagga gtctcggcgc ccgcaggacg acggcggtct cccgcggtgc ctcgtggcgg 6181 tcgacggcgt ggacggcgaa cccgtcgccg tcacggacgg cggaccacac atggtgttcc 6241 aggcgcaggt cgagccggcc cgacgtccgg tgtgcggcca gcgccttgca cagggcgcgg 6301 tagcggtcca gtccgtggtg caggtcgtcg gtcggtacgg ccgctcgggc gtgctcgggc 6361 gggtggcgcc agtactgacc gccgagggcg gttcccgagt ccagcagtac gacgcgcagt 6421 ccaccggcca gcgcggtggc ggcggcggcc aggccggccg ggcccgcgcc gacgacgatc 6481 aggtccgcgg ggtcagtcat cgtcgccctc cccggtcgtg acggtcatac ccggccgggc 6541 cggcaccagg caggcgcgct gcccgggggc tccgtcgacg gtgacgaggc agtcgaagca 6601 gacgccgatg ccgcagaaga cgccacgcgg gcggtgcccg acgcgggtgg tgcgccaggc 6661 gaggcggccc gtggccacga gggccgcggc gacggtctgt ccctcgacga acggcagggg 6721 ccggccgtcg acgatcatct cggtcactgg ggcacacctc cgggggtgag gaaacggtcc 6781 gggagaaggc cgctgtgggc ggccgggtcg gcaccgcgcc agggccggcc gagcaggtgg 6841 gcggtgacga gcgcgcccgt tccgggggcc agtccgacgc ccgctccctc gtgcccgcac 6901 gcgtggacga cgcccggcac gcgcgggtcg gggcccacca ccggcaggtg gtccgggcag 6961 tacggccgga acccgcggta ggcgcgcatc agatggaccc cgcgcaggaa ggggaagagc 7021 cggcacgcct gggccgcgag cctggcgacc acggcggtgt tcatcgtggt gtcgaagccg 7081 acgcgttccc ggctggcgcc gatgaggacg gtaccgccgc gggtgccctc cacgacgcac 7141 gaagtctcca gtccggcgtc ggaggaggcg acgttggcca cgtagtcggc ggagtagacc 7201 ttgtgccgga ccatcggcgg cagcggttcg gtcaccagga cgaagccgcg gcgcggcagc 7261 acctcgacgg gagcgccgag ccgtcggccg acctcaccgc cccaggtccc ggcggcgttg 7321 acgacggcgt cggcgggcag cacgtcacct gcggccgtcc ggacaccggt gacgcggccg 7381 tcccggccgg tcaccgcccc ggccacctcg ccctggtgga agcgcgcgcc gcgccgcagg 7441 gcggctcgca gcagcgcggc cgccgccagc accggctgca cctgtgcgtc ctgcgggtag 7501 tggacaccgc cggggatgtc gggtgcgagg tggggttcga ggtcccgcac ccggtcgacc 7561 cgctcgacgc ggacgccggc cgcctcctgc cgggcggcga actcccggag cgtcgcgagg 7621 ttctcggcgc cgctcgcgac gaccaggccg cccttgggct cgagttcgag ggtgtcgggg 7681 cccagctcct ggccggcctc gtcccacagg gtgcggctca ggcgggccag ggccagttcg 7741 gggccgggtt ccttgtcgga gaggaggacg ttgccctctc cgcggctcgt cgtcccggcg 7801 ccgacggggc cgcggtcggt gaccgtgacg tccaggcccg ccgaggcggc gtggaaggcg 7861 caggcggctc cgacgactcc cgcgcccacg acgacgactt tccgggtcaa cggctcctcc 7921 tcgcgcacgc atcccactgt gcaatgtcac atgccatggg tgaggctata catccggcag 7981 gcgtaagaca acgcccacgt cgccgacttc gcgcccgggc ggtcggggag ggtcagaggt 8041 cgactcgggt gccgaggccg gtcagggcgc cgaccgggtc gaggtcgggt gtgccgcgcg 8101 gccaccagtc ctcgcggccg ggctccgact cgtacgcgta ccagagcccc gcgcggccga 8161 gtctgagctg gacatggccc cgggggtggg tgaggcggtt gcgccagggg cggaaggcgg 8221 ggagatcggc ggcgagcagc agggggcggg cgcggtcgaa ccggccggcc ggcgggtccc 8281 agggctcctc caggacgtcg aggccctcgg gtccgccctg ccgccaggcg gcgacggccc 8341 gcgccagctc cgccgtgtcg cgcccggcgg ccgaggcgag ggacgcgtag agcgcgcggg 8401 tgcccgcggt gagcccggag ccggggcgcg ccgcggcgag ccggacggcg tcctgccaca 8461 gcgtcagtcc gccgaccggg tcccgtccgg tggtgagcag ggcgtgcgcg cgggcggccg 8521 cgtcggtggc caactggtcc agcgcgaacg ggtcggggcc gcccggtgcg cccgggtagg 8581 caggcggctg ctcggggtgc gggggcgcgg gcagcggcgg cgggaggggc ggcagggcgc 8641 gcggggtcag ggccgcaccg gcccggacgc cgggcagggg cgccggtccg cggtcctggg 8701 ccgcacgggc cgcgcgggcc gcgttccgcc gggacagggc gtcgagcagc gcgcgctcgc 8761 cccggccgcg cagcaggagc aggacgaagg ggtcggcgtc gagcagacgt gccgtctggt 8821 agcagagggc ggcggcgtgc ttgcaggggt gaccggagtc ggggcagctg cactgcgggg 8881 tgaggtcgcc ggggccgggg agcagcggga cgccgcggtc ggccaaatcg gccagggagt 8941 gcggcagttc cttgtcgagc agggcggcga tgtgcccggg ccgttcgacg gcggcgtcca 9001 ggaaccggtc ccagtcggcg tcgccgagcg tccgcagccg cacctggacg cggtacggcc 9061 gggcgcggct gccctgcacg tagccgagga ccagccccgg cgtcacggtg atggcgtcga 9121 cgtgtccccg ctccgcgtag ccgcgcccgc gctccagccg ggcggcgtcc agggcgcctt 9181 cctccagcgc cgtcacccac gcgtttcccc accaggtccc ggcgaagccc tcgtctgcgg 9241 cctcccgggg cggcaacgcg gcaaaggtgc ggcggaggtc gccgtcgcgg tccggggcag 9301 ccatcgaacg aggtgcgcgg ggctgcgcgg ccgacacgga gccgtcccgg ccgcgcgccg 9361 ccgccggctg ctgctgctgc tgcgaacgcc gcgaccactc ggcgacggac cccgcccctt 9421 ccgaacgcga cgcgtgcccg gcccgtgcgg gggcgagggc gcccccggtg gtacgaccgt 9481 cgtcggcgga tccgccgaca tgaccgccgt cggcggcgaa tccggcactg cgttcggcac 9541 cggtggctcc ggcactgtgg tcggcgccgg gcgacggctc cggcgccggg tgggcggccg 9601 ccgggccctc cgaggcactg cttccggtgg cggagccctc ggtggcggaa ccctcggccg 9661 actcccgggc aggcggggcc tcctcggccg ggtcctcctc cgggggcagc cggaaggcgc 9721 ccgcgaagga accccgtacg gcacggtcgc ccccgggcga cgaacccgac ccccggcgcg 9781 cgacctcccg cacctcggcg accggcccac cggccgactc cccagcgggc agggcctcct 9841 cggccgggtc ctcctccggg ggcagccgga aggcgcccgc cgcaaagccc cgtaccgcac 9901 gagccgcggc acggtcgccc ccgggcgacg aacccgaccc ccggcgcgcg acctcccgca 9961 cctcggcgac cggcccaccg gccgactccc cagcgggcag ggcctcctcg gccgggtcct 10021 cctccggggg cagccggaag gcgcccgcgg cgaagtcgcg tacggcacgg gcgcgggcgt 10081 cggcggtggc cgggccgcgc gctggccgct gaccaccggc cgggcgggac gaacgccgcg 10141 cgggtgccgc gctgttggcg gacccgcctt cggacgccgc gtccgccttc gcctgccgac 10201 gcgccgcccg caacgcctcg cgcgccacgt ccgccggacg ggcggaccgc gcgccgactg 10261 agccggggga cgacggcccg tcgggaacac ctcgaccgcc cgaaccgtcc aagccgtccg 10321 aaccgtccga gctgtccggt tcggtcgtgt cgtcggtccc ggcggtcttc tcgccgggaa 10381 ctgtcggctc cccgccgggc tgagggtcct ccgagcccgt cgggtcggct cggtctggcg 10441 aggcgaccgg ggcgaccggt tccgccggga ctccgcgatc tcccagggcc gccgaaccgg 10501 ccgggagtgg acccggtggc ggcgtgtcgg aggcgttggc ggcgtcgggc tcgccggggg 10561 cgtcgtgtgg cgtgtcaggg acgtctgcgg ggtcgtccgc ccccgtatgc cgtgcggtgc 10621 gcgcgctacg cagtgcggcg cgggccatgt ccccggggcg tgacggggtg gggtcccccg 10681 gcgtctgctc cgagaccccc tcccgccccg cggccggatc cgcggccggg gccggcgacg 10741 acggcgacga cgaccggggc ggtgacggcg ccccgcggtc gccgtcaccg ctcgtcggct 10801 cgcctcgccc ccgtgcctcc cgcagggcgc ggcgggcctc gtcggcgggc cggggggtca 10861 cgacggcctc cgcagggaca cgaggtcgga cagctcacgg gccgtcagtt cggtgagggc 10921 cgactccccg gagccgagga tcgcgtcggc cagggcccgc ttggactgga gcatctcggc 10981 gatgcggtcc tcgaccgtgc cctcggtgat gagccggtgg acctggaccg gctgcgtctg 11041 tccgatccgg tacgcccggt cggtggcctg ctcctccacc gcagggttcc accagcggtc 11101 gaagtgcacg acgtgaccgg cacgggtgag gttgaggccg gtgccggcgg ccttcaggga 11161 caggacgagg acgggggtcg cgccgctctg gaagcggtcc accatccgct cgcgctccgg 11221 caccggcgtg cccccgtgca gcaggtcgac cgggaccgcc cgggcggtca ggtgcgcggt 11281 gatgaggcgg gccatgccga cgtactgcgt gaagaccagc gccgagccgt cctccgcgag 11341 caccgtgtcc aacagctcgt ccagcagcgc cagtttgccc gagcgggcgg tcatccgttc 11401 ggcgccgccc ggcgggtgct cctccttcag gaacagcgcg ggatggtcgc agatctgctt 11461 cagcgaggtc agcagcttga gcacgagccc gcggcggccc atgccctcgg cctcctcgat 11521 ggcgagcatc gactcgcgca ccaccgcctc gtacagcgcg gcctgctcgc gggtgagcgg 11581 gaccgggtgg tccgtctcgg tcttcggcgg cagctccggg acgatgcccg ggtcggactt 11641 cctgcggcgc agcaggaagg ggcggatcag ccgggcgagg cgctccaccg cctggtcgtc 11701 ctcgccgttc tccaccgcgc gcgcgtgccg ggcgcggaag gatttcaggg ggccgagcag 11761 tccgggcgtg gtccagtcga gcagggccca cagctcggag aggttgttct ccacgggggt 11821 gccggtcagg gccacccgcg ccggggacgg gatggtgcgc agggccttcg ccgtcgccga 11881 gtacgggttc ttgacgtgct gcgcctcgtc cgcgacgacc atgccccagg gctgctcggc 11941 cagggtcgtg gcggcggacc gcatggtgcc gtaggtggtg aggacgaagc cgccgctcag 12001 gtcgtcgagg gtgcggtcgg ctccgtggaa gcggcggacc gggacgccgg gcgcgaaccg 12061 ctcgatctcc cgctgccagt tgcccagcag ggaggccggg cagaccacca gggtcggttc 12121 ggtgcgggcc cgtttcaggt gcagggcgat gacggtgacg gtcttgccga ggcccatgtc 12181 gtcggcgagg cagccgccaa ggccgagcga ggtcatgagg tggagccagg cgaggccgcg 12241 cagctggtag tcgcgcaggg tggcgtgcag gccgggcggc ggttcggcgg ggcgcacgcc 12301 tgccgtcagc cggtcgcgca gggcggccag cgcgccgacg ggcaccacgt cgaccgtctc 12361 gccgtcggcc tccgcgctgc cggtgagggc gacggacagg gcgtcgaccg ggtcgagcag 12421 gcccagctcg cgcttgcggg cccggcggac gagcgccggg tcgaccagca cccagcggtc 12481 ccggagccgg acgacgggac ggtgggcctc cgcgagggtg tccatctcgg cctcggtgag 12541 cgggtcgccg ccgatcgcga gctgccagcg gaactggagg aggtcctcgc tctcgaagaa 12601 ccccgtgccg tcggtcgccg aaccgggcgc cgtcctgatc accgcggtcg ccgtgaggtc 12661 ctgggccagg tcccgcggcc agtgcacggc gaccccggcg gcggcgagcc gcccggccgc 12721 caccccgagc aggtcggtga cctcctcctc ggacagggcg agcacgtcgg gcacgtcctg 12781 ctcggtgagc cggtccagcg gcggccagac ccgggccgcg cgccgtaccg ccagggcggt 12841 gtccacgcgc gcgcgggccc cgaacgccgc gtcggccgtc cccgaccaca ggtccgccgc 12901 gtcggcgacg //