LOCUS NZ_KZ195574 10216 bp DNA linear CON 06-SEP-2024 DEFINITION Streptomyces sp. CS113 scaffold00001, whole genome shotgun sequence. ACCESSION NZ_KZ195574 VERSION NZ_KZ195574.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. CS113 ORGANISM Streptomyces sp. CS113 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C., Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines JOURNAL Front Microbiol 9, 39 (2018) PUBMED 29441046 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Searching for glycosylated natural products in actinomycetes isolated from leaf-cutting ants: activation of two silent clusters and identification of a novel macrolactam JOURNAL Unpublished REFERENCE 3 (bases 1 to 8695358) AUTHORS Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A. TITLE Direct Submission JOURNAL Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia, Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006, Spain COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.9 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 78.17x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_002188365.1-RS_2024_09_06 Annotation Date :: 09/06/2024 02:31:13 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,790 CDSs (total) :: 7,719 Genes (coding) :: 7,614 CDSs (with protein) :: 7,614 Genes (RNA) :: 71 rRNAs :: 2, 1 (5S, 16S) complete rRNAs :: 2 (5S) partial rRNAs :: 1 (16S) tRNAs :: 65 ncRNAs :: 3 Pseudo Genes (total) :: 105 CDSs (without protein) :: 105 Pseudo Genes (ambiguous residues) :: 0 of 105 Pseudo Genes (frameshifted) :: 35 of 105 Pseudo Genes (incomplete) :: 81 of 105 Pseudo Genes (internal stop) :: 4 of 105 Pseudo Genes (multiple problems) :: 15 of 105 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 09:56:45 NOTE :: This is a single region extracted from a larger record! Orig. start :: 719342 Orig. end :: 729558 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to KZ195574.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Prof. Salas's laboratory, A. Microbiology, University of Oviedo, Spain. FEATURES Location/Qualifiers region 1..10216 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="5" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..10216 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..10216 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:5216](+)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core 5001..5216 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" gene complement(220..2715) /locus_tag="B9W62_RS03000" /old_locus_tag="B9W62_03010" CDS complement(220..2715) /EC_number="3.1.3.16" /GO_function="GO:0016791 - phosphatase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003978110.1" /locus_tag="B9W62_RS03000" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_03010" /product="SpoIIE family protein phosphatase" /protein_id="WP_087804918.1" /transl_table=11 /translation="MSYKRCNGDVVSQGAAERGPRTLRAEGALKAIAAGPQPEQRLRGI LEQALVFAGASLAALYAPGDDPELLCLVESAGVPRTLYGVRDSYPASGGSPVADAHRAG EAVWMGPEEFAGSAESRHVPSSGFSLAVLPVRGDGGGCLLALTERPDGFDADDRACLEV IAEAMTCPVPAETVETAEHVEGGALRPDAFTLAMDTGRAEVGDDILRLFGLAPGEFDGK VETLLGLTVPEDLPSLMSVTESDHMSIGERELEFRVLQPTGPPKWLRLSGRLLPGGDGR PTLLVGTVADASTLRPDVTDVARVQQLAAALATAGTVRDVSQAVVAALRRPLRADRIAL AELENDRLVVTVLDPPDPESWPELWRLEWRTEWPDAPVRAMPTLAAALREGRARIWPAG TDDVEPALADVGPGGLAVLPLPAGGRMAGACLIGWDTPHDFGPDERALLTASAGLAGQA LMRAHAFDAEHELVGMLQRQLLPRRLPKLPGAVAVARYLPSTAGLELGGDWYDVIPLPD HHVALVIGDVQGHSAGAATLMGQMRTALRAYAVEVHPPDVVVSHANRLLTGMETDLFAT CVYVDLDMEEGSAWCVRAGHLPPVLRHPDGSTEIAEVEGGPPLGVVTQADFPMSPLRLR PGTLIALTTDGLVETPESDIDEGMDRFAHALAVSAPAHLGLVADALLGNARRNDDVALL LVRYDGMALRPLRESWSVWRLPEAVRHARRFTRRTLRIWDIPDDDIDGVLLIVSELVTN ALVHTDGKVRLDLTLISGRLRVAVADASPRTPVKPTSIGWEATGGRGILLVEAMSATWG TLPVSGGKQVWSEIPVGGG" misc_feature complement(2696..2709) /note="TFBS match to PerR, Peroxide regulator, confidence: weak, score: 12.56" /tool="antismash" gene complement(3120..4418) /locus_tag="B9W62_RS03005" /old_locus_tag="B9W62_03015" CDS complement(3120..4418) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003978109.1" /locus_tag="B9W62_RS03005" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_03015" /product="S1 family peptidase" /protein_id="WP_087804919.1" /transl_table=11 /translation="MSHKRIPKRRAAMAAGGVVALGAAAILLPNANASQDGGSPDDAPA APRTLKAADASDLAVRLAGLLGDTFAGSYYDAAARQLVVNVVPGGDDQVVTQAEKAGAE VREVDHSMGELRSGAQTLKSEASIPGTSWAIDPRTNKILVTADRTVTGDRWDRLESTVE GLGSGMATVRKSAGTFKTFASGGDAIFGGGARCSLGFNVTAGDGSPAFLTAGHCGVAAD QWSDAQGGQPVGTVDQAVFPGEGDFALVTYDDPATEAPSEVNLGDQTLPISGPAEATVG QEVFRMGSTTGLADGQVLGLDATVNYPEGTVTGLIQTDVCAEPGDSGGSLFTRDGLAIG LTSGGSGDCTVGGETFFQPVTTALEAVGATLGGEDAGAGAGEEGAGGAGDVGDAGDGSG EGSGVGSEDGSGVGETGDGAAVGGGDGTDGLTG" gene 5001..5216 /locus_tag="B9W62_RS03010" /old_locus_tag="B9W62_03020" CDS 5001..5216 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: strepbact" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020128984.1" /locus_tag="B9W62_RS03010" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_03020" /product="hypothetical protein" /protein_id="WP_003978108.1" /sec_met_domain="strepbact (E-value: 2.3e-37, bitscore: 126.1, seeds: 15, tool: rule-based-clusters)" /transl_table=11 /translation="MNSTPQVETVEISDADLDNVSGGLNVNAVGTVTGLVDGIAPVSGL LNTAVGTVEGVTGLNTAPVTGLVAGL" gene 5337..6143 /locus_tag="B9W62_RS03015" /old_locus_tag="B9W62_03025" CDS 5337..6143 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007386622.1" /locus_tag="B9W62_RS03015" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_03025" /product="HlyD family efflux transporter periplasmic adaptor subunit" /protein_id="WP_087804921.1" /transl_table=11 /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLVLSVTVVAMAAASVW AVGGSVTSTVAAPAILTHGQGSYLLQSPVSGQVTAVLARPGQRLAADAPVLKVRTAEGE TVVRSIDAGRVSALAATVGQIISTGANVASVEKVAHADDPLYATVYVPAEKAAAIPAHA SVDLTVQSVPTQQYGVLHGEVKAVDRSAQSAQTITAFLGDSQLGEQFTEDGRPVAVTVR LDTSESTKSGYAWSSADGPPFGLTSMTLASGSIRLADQRPVDWLLP" gene 6140..8362 /locus_tag="B9W62_RS03020" /old_locus_tag="B9W62_03030" CDS 6140..8362 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0008233 - peptidase activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_C39" /gene_functions="transport (smcogs) SMCOG1288: ABC transporter related protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003978106.1" /locus_tag="B9W62_RS03020" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="B9W62_03030" /product="NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit" /protein_id="WP_087804923.1" /sec_met_domain="Peptidase_C39 (E-value: 1.9e-39, bitscore: 133.3, seeds: 36, tool: rule-based-clusters)" /transl_table=11 /translation="MSTAQETRGRRRAAPPKRTVPKPRAKTVRTPTVLQMEAVECGAAS LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGFTAKGMQMDLAALAEVTA PAILFWEFNHYVVYDGMGRRFGRRGVFINDPGKGRRFVSLEDFDGSFTGVVLTMEPGED FTRGGRRPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQT SLLGVLFASMGACVLLTVVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTFVGIGVALLNIL AMRVVIRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE EQQRLGVPSAWLGVVAPTLATLNSGLILWIGGMRAVEGHISVGLLVAFQALVVRFTAPL TRLNGVAGRIQDFAADVARLKDVENFRADPLYDRPGGGDSTRRLHGHVELQNISFGYNP LDKPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWDGVIRIDGQRLDDIPR GALASSVSFVDQDVFLFEGSVRDNVALWDPSIPDDAVVDALKDAALYDVVMRRPGGLHS PVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACV VIAHRLSTVRDSDEIVVLEHGTVVERGRHAELVAHGGAYAALVGER" misc_feature complement(9036..9050) /note="TFBS match to MexT, Global virulence regulator, confidence: weak, score: 15.56" /tool="antismash" misc_feature 9261..9277 /note="TFBS match to NtrC, Nitrogen regulatory protein C, confidence: weak, score: 21.67" /tool="antismash" misc_feature complement(9692..9701) /note="TFBS match to AbrC3, Antibiotic production activator, confidence: strong, score: 18.16" /tool="antismash" ORIGIN 1 cggacggcgg gtttgccgcc ggtgtccgtg gtcacggggc atcatcttcc ttctcgttct 61 gcatcggtgc gctcgccatt ccgggtcccc gggcggggca ccgcgaaaca ccgggcacat 121 gtgtcccgcg gtgcccaggt gttggggccg ggccgcgctg atgtcgtggg gcagccgggc 181 gggtacccgg cggtgcggtg gccgaaccgg ccggggcgtt cagcctccgc ccaccgggat 241 ctcgctccac acctgcttgc ccccgctgac cggcagcgtc ccccaggtcg ccgacatcgc 301 ctcgacgagg aggatgccgc gcccgcccgt ggcctcccag ccgatgctgg tcggtttgac 361 gggtgtacgc ggcgaggcgt cggcgaccgc gacgcgcagc cggccgctga tcagggtgag 421 gtcgagccgt accttgccgt cggtgtgcac cagggcgttg gtgaccagct ccgagacgat 481 cagcaggacg ccgtcgatgt cgtcgtccgg tatgtcccag atgcgcaggg tgcgccgggt 541 gaagcggcgg gcgtgccgca cggcctccgg cagccgccac accgaccagc tctcgcgcag 601 cgggcgcagg gccatgccgt cgtagcgcac cagcagcagg gcgacgtcgt cgttgcgccg 661 ggcgttgccg agcagggcgt cggcgacgag tccgaggtgg gcgggggcgg agacggccag 721 ggcgtgtgcg aaccggtcca tgccctcgtc gatgtcggac tccggcgtct ccaccaggcc 781 gtccgtggtg agggcgatca gcgtgccggg ccgcagccgc agcgggctca tcgggaagtc 841 ggcctgcgtg accacgccga gcggcgggcc gccctcgacc tccgcgatct ccgtgctgcc 901 gtcggggtgg cgcagcaccg gcggcaggtg cccggcccgc acgcaccagg cggagccctc 961 ctccatgtcg aggtcgacgt agacgcaggt ggcaaagagg tcggtctcca tacccgtcag 1021 cagccggttg gcgtgggaca ccaccacgtc cggcgggtgg acctcgacgg cgtaggcgcg 1081 cagggcggtg cgcatctggc ccatcagggt ggccgcgccg gcgctgtggc cctggacgtc 1141 gccgatgacc agggccacgt ggtggtcggg cagcgggatc acgtcgtacc agtcgccgcc 1201 cagctcgagg cccgccgtgc tgggcaggta gcgggcgacg gcgaccgcgc cgggcagctt 1261 cggcagccgg cgcggcagca gctggcgctg gagcatgccg accagttcgt gctcggcgtc 1321 gaaggcgtgg gcgcgcatca gggcctggcc ggcgagaccg gcggaggcgg tgagcagggc 1381 gcgctcgtcg gggccgaagt cgtgcggcgt gtcccagccg atcaggcagg cgccggccat 1441 gcggccgccg gcgggcagcg gcagcacggc caggccgccg gggccgacgt cggcgagggc 1501 cggttcgacg tcgtcggtgc cggcgggcca gatccgggcg cggccctcgc gcagcgcggc 1561 ggcgagggtg ggcatggccc gtaccggtgc gtcgggccac tcggtgcgcc actccaggcg 1621 ccacagctcg ggccaggact cggggtcggg cgggtcgagg acggtgacga cgagccggtc 1681 gttctccagc tcggccagcg cgatgcggtc ggccctgagc ggtctgcgca gggcggcgac 1741 gacggcctgg ctgacgtcgc ggacggtccc ggcggtggcg agcgcggcgg cgagctgctg 1801 cacgcgggcg acatcggtca cgtcggggcg cagcgtggag gcgtcggcga cggtgccgac 1861 caggagggtc ggcctgccgt cgccgccggg cagcaggcgc ccgctgagcc gcagccactt 1921 cggcggaccg gtgggctgta gcacacggaa ctccagctcg cgctcgccga tgctcatgtg 1981 gtcggactcg gtcaccgaca tcagggacgg caggtcctcc ggcacggtga ggccgagcag 2041 cgtctcgacc ttgccgtcga actccccggg ggcgaggccg aacaggcgca ggatgtcgtc 2101 accgacctcc gcccggccgg tgtccatggc cagggtgaag gcgtccggcc ggagcgcacc 2161 gccctcgacg tgctcggcgg tctccacggt ctcggccggg accgggcagg tcatcgcctc 2221 ggcgatcacc tcgagacacg cacggtcgtc ggcgtcgaac ccgtccgggc gctcggtcag 2281 ggcgaggagg cagccgccgc cgtctccgcg cacgggcagg acggcgagcg agaagccgct 2341 cgacggcacg tgccgcgact ccgccgatcc ggcgaactcc tccggcccca tccacaccgc 2401 ctcgccggcc cggtgggcgt cggcgaccgg ggagccgccg gaggcgggat agctgtcgcg 2461 tacgccgtac agggtgcggg gcactccggc cgactcgacc aggcagagca gctcggggtc 2521 gtcgccgggc gcgtagaggg cggccaagga ggcgcccgcg aagaccaggg cctgctcgag 2581 gatgccccgc aggcgctgct ccggctgcgg gccggccgcg atcgccttca gggcgccctc 2641 ggcacgcagc gtcctcggtc cgcgttccgc agcgccctga ctgaccacgt cgccattaca 2701 gcgcttatag gacatctgcg cagcccctac ggctcgggta ccggcgatca ggagcacttc 2761 gggggctcgc ggaccggcat tgcgcgccgc ggtgcggcgg gacgcactcg tggggcgggg 2821 gcgggcacgg tcgggcaggg gcgggtacgg cacgcggcgc ggcgccgcgc gaggtaccgc 2881 gaggcggtcc cgggcccggt ggccactggt gcgcgagggc gcggggcgcg ggtgccgggt 2941 gcgcgggtgc gcgcgaggga ggggcacgga ccgtcgggcc cgcccggggg ctcccgccgc 3001 ccgggccttc ggccgccgga tcgccgcccg gtcccgtcgg cgggggtccg ggcggcgatc 3061 cgtgggccgt ggtgtcaacc cgtggtgtca gcccatcagc ccatcagccc atcagcccgt 3121 cagcccgtca gcccgtcggt cccgtccccg ccgccgaccg ccgcaccgtc gccggtctca 3181 ccgacaccgg acccgtcttc agagccgaca ccggaccctt caccggagcc gtcaccggca 3241 tcgccgacgt ctcctgcacc acctgccccc tcctccccgg cacccgcgcc ggcgtcctcg 3301 ccgccgaggg tggcgccgac cgcctccagg gccgtggtga ccggctggaa gaaggtctcg 3361 ccgccgaccg tgcagtcacc gctgccaccc gaggtcaggc cgatcgcgag gccgtcccgg 3421 gtgaacaggg agccgccgct gtcgcccggc tcggcgcaca cgtcggtctg tatgaggccg 3481 gtgacggtgc cctcggggta gttgacggtg gcgtccaggc cgaggacctg gccgtcggcc 3541 agcccggtcg tactgcccat gcgaaagacc tcctggccga ccgtcgcctc ggcgggcccg 3601 ctgatcggca gggtctggtc gccgaggttc acctcgctcg gcgcctcggt cgccgggtcg 3661 tcgtaagtga cgagtgcgaa gtcgccctcg ccggggaaga ccgcctggtc gacggtgccg 3721 accggctgcc cgccctgcgc gtcggaccac tggtcggccg cgaccccgca gtgaccggcc 3781 gtcaggaagg cgggcgagcc gtcgcccgcg gtgacgttga agccgagcga gcagcgcgca 3841 ccgccgccga agatggcgtc gccgcccgac gcgaaggtct tgaaggtgcc ggcggacttc 3901 ctgaccgtgg ccatgccgga gccgaggccc tcgacggtgg actccagccg gtcccaacgg 3961 tcgccggtga cggtgcggtc cgcggtcacc aggatcttgt tggtgcgcgg gtcgatcgcc 4021 cacgaggtgc ccgggatgct cgcctcggac ttcagggtct gcgcgccgct cctcagctcg 4081 cccatgctgt ggtcgacctc gcgcacctcc gcgcccgcct tctcggcctg cgtgacgacc 4141 tggtcgtcgc cgccggggac gacgttgacg accagttgcc gcgcggcggc gtcgtagtag 4201 gagcccgcga aggtgtcgcc gagcagcccg gcgagccgta cggccagatc cgacgcgtcc 4261 gccgccttga gggtcctggg cgcggccggg gcgtcgtcgg gggagccgcc gtcctgcgag 4321 gcgttggcgt tcggcagcag gatcgcggcc gcgccgagcg ccaccacacc gcccgccgcc 4381 atcgcggccc tgcgcttcgg gattcgcttg tgactcaacc tgctcgacct cctgggaccg 4441 gggttggcac ccgccggtcc ggcagctgtt ggggggcgcc cggacggctg ttggtacgca 4501 cgggccgccc cggacgttca gccggacccc cgccccgccc ccggccggca ctctccgcgt 4561 ccgatcggcg acgcaccgtt ccgatcacgg agcggaatga ccgcttcagt gaatctgcac 4621 atcgaatgcc caacccggtc actcccgttg gcgcatctgc acaagccgga ggcggcccgt 4681 acgtctttgg ggccggagtg tcccaatcgc ctccccggag gcaaggggtc gcacgagtcg 4741 atgtcgcgca gcgtgtgaag aagtcgccgc gaaggcgtgc gcgctcctgc acgcttgggt 4801 gcccgggcgt cgcaagtgcg ctggtgagag gggtgattga ttggaagccc ggcccggtcg 4861 cgtgctttga tccatcgcac cgcgggggcc gcggagggct cgggaaacgg gcgcccggcg 4921 cccgcggtcg cggccgtcat ctgtccccag agggggccgc tccccccttg tgaaatggct 4981 atacgaaggg aagttccatc atgaactcca ccccccaggt tgagaccgtc gagatctccg 5041 acgccgacct cgacaacgtc tccggcggcc tgaacgtgaa cgccgtcggc accgtcaccg 5101 gcctggtgga cggcatcgcc ccggtctccg gcctgctcaa cacggccgtc ggcaccgtcg 5161 agggtgtcac cggcctgaac accgccccgg tcacgggcct ggtcgccggt ctctgatcgc 5221 gcccttgcgt cgctgagtcc cggagccgtc caggctccgg gacttttcgg ccgttcccga 5281 cttcccgacg ttctcgtcat gtcggccgtt cacaccgagc cctggattcg tcagccgtgc 5341 agttccgcca acaggccctc gccaaactcc agtcaccgga ggagctcgat ctcccggtgc 5401 gcttcgcccg tccccagggc tggctggtgc tgtccgtgac cgtggtcgcg atggccgccg 5461 cgtccgtgtg ggcggtgggc ggctcggtga cctccacggt cgccgctccc gccatcctca 5521 cccacgggca gggcagttac ctgttgcaga gtcccgtctc ggggcaggtc accgcggttc 5581 tggcccgccc ggggcagcgg ctggccgccg acgccccggt gctgaaggtc cgcaccgccg 5641 agggcgagac ggtggtccgc tcgatcgacg ccggccgggt cagcgcgctc gcggccaccg 5701 tcgggcagat catcagcacc ggcgcgaacg tcgcctcggt cgagaaggtc gcccacgccg 5761 acgaccccct gtacgccacc gtctacgtcc ccgccgagaa ggccgccgcc atccccgcgc 5821 acgcctccgt cgacctgacc gtccagtcgg tgccgacaca gcagtacggc gtcctgcacg 5881 gcgaggtgaa ggccgtggac cgctcggccc agtcggcgca gacgatcacc gcgttcctcg 5941 gggacagcca gctcggcgag cagttcaccg aggacggcag gccggtggcc gtgacggtgc 6001 ggctggacac ctccgagtcc acgaagagcg gctacgcgtg gtcctcggcc gacggaccgc 6061 cgttcggact gacctccatg acgctggcct cgggctccat ccggctcgcc gaccagcgtc 6121 ccgtcgattg gctgctgccg tgagcaccgc acaggagacc cggggcaggc gccgggccgc 6181 cccgcccaag cgcacggtgc ccaagccgcg ggcgaagacg gtccgcacac ccaccgtgct 6241 ccagatggag gccgtggagt gcggtgccgc ctccctggcg atggtcctcg gccactacgg 6301 ccgccacgtc ccgctggagg agctgcgcat cgcctgcggc gtctcccgcg acggctcgcg 6361 cgccagcaat ctgctgaagg cggcccggag ttacgggttc accgccaagg gcatgcagat 6421 ggacctggcc gccctcgccg aggtgacggc gcccgccatc ctgttctggg agttcaacca 6481 ctacgtcgtc tacgacggga tgggccgccg gttcgggcgg cgcggggttt tcatcaacga 6541 cccgggcaag ggccgccgtt tcgtgtccct ggaggacttc gacggcagct tcaccggggt 6601 cgtgctgacc atggagcccg gcgaggactt cacccggggc ggccgccggc cgggtgtgct 6661 cggcgcgatg ccggcccggc tgcgcggcac ggccgggacg ctgcccgccg ccgtgctggc 6721 gagtctgctc ctggtggcgg tcggcgcggc ggtgcccgcg ctcagccgca cctacatcga 6781 catgttcctg atcggggggc agacctcgct gctcggcgtg ctgttcgcgt cgatgggggc 6841 gtgcgtcctg ctcacggtgg tgctgacctg gctccagcag gccaacctgc tgcacgggcg 6901 catcatctcc tccaccctgt ccagcgcccg cttcctgcgg cacctgctgc ggctgccggt 6961 gaccttcttc tcccagcgca gcccggccga cctggtgcag cggctccagt ccaacgacgc 7021 cgtcgccgag acgctggccc gcgacctcgc cgcggcgggc gtggacgcga tcgtggtcgt 7081 cctgtacgcc gtgctgctgt acacgtacga cccgcagctc accttcgtcg gcatcggcgt 7141 ggcgctgctc aacatcctgg cgatgcgggt cgtgatccgg ctgcgcgcga cccgtacggc 7201 gaagctgcgg gcggacacgg cgcggctgac caacaccgcg tacaccggcc tccagctgat 7261 cgagacgatg aaggcgaccg gcggcgagga cggctacttc cgcaagtggg ccggccagca 7321 cgccaccacg ctggaggagc agcagcgact cggggtgccg agcgcctggc tgggggtggt 7381 ggcacccacg ctggcgacgc tcaacagcgg gctgatcctg tggatcggcg gcatgcgcgc 7441 ggtcgagggc cacatctcgg tcggtctgct ggtcgccttc caggcgctgg tggtccgctt 7501 cacggccccg ctgacccggc tgaacggcgt cgcgggccgc atccaggact tcgcggccga 7561 cgtggcccgg ctgaaggacg tggagaactt ccgcgcggac ccgctctacg accgccccgg 7621 cggcggcgac tcgacccgcc ggctgcacgg ccacgtcgag ttgcagaaca tctccttcgg 7681 ctacaacccg ctcgacaaac cgctgctcac cggcttcgac ctgaccgtcg gcccggggca 7741 gcaggtggcc ctggtcggcg ggtcgggcag cggcaagtcg acggtgtcgc ggctgatctc 7801 gggcctgtac gcgccctggg acggcgtgat ccgcatcgac gggcagcggc tcgacgacat 7861 cccgcgcggg gcgctggcgt cctccgtctc cttcgtcgac caggacgtgt tcctgttcga 7921 gggctcggtg cgcgacaacg tggcgctgtg ggacccgtcg atccccgacg acgccgtggt 7981 ggacgcgctc aaggacgccg cgctgtacga cgtggtgatg cgcaggccgg gcggcctcca 8041 cagcccggtc gagcaggacg gccggaactt ctccggcggg cagcgccagc gcctggagat 8101 cgcgcgggcc ctggtgcgcc ggccgagcat cctcgtcctg gacgaggtga ccagcgcgct 8161 ggacgcggag acggagctgg tggtcatgga caacctgcgc cggcgcggct gcgcctgcgt 8221 ggtgatcgcg caccggctca gcaccgtgcg ggacagcgac gagatcgtcg tcctggagca 8281 cggcacggtg gtggagcgcg ggcggcacgc ggagctggtg gcacacggtg gcgcgtacgc 8341 ggcgctggtc ggggagcgat gagatgacga ccgtgcagga gggacagggc gacctcgtcc 8401 tcggggcgct cggctcgctg ggcacccgcg tcgactgcgc cgggttcaac cgcctcgacc 8461 tggaggggcc gcaggtgctg tggctggtgg tgtccggtgc ggtggacctg ttcgcggtcg 8521 acgccgggga gcagggccac tggcaccacc tgggacgcct ggaggcgggc tcggcgctcc 8581 tcgggccggt cgccggaccg cggcacacgc tggtggcgcg tccgctgcgg gactgcgtgg 8641 tgcaccgcat cggactgcgc gagctgtacc agccggcgaa cacccagacc tggtcgtacg 8701 acgcgtacgg caacccgcag tacgtgccgc cgacgacgag cccgctggag tacgccctgg 8761 ccctcggcgt ggggcgtggc ctgacggtcc tcttccaggc gccgatggcc gcggagcggg 8821 ccggcgcacc cacggacgac gacgtgttct ggatgcaggt gccgccgggc agcgtgcagt 8881 acggggcggt gtacggcgag gaggcggccg ccgacctgct gatggacccg gcgctgtggc 8941 agagcctggt cgaccagcaa taccggctgc tgaccactct ggaccggtgg atcgagcagc 9001 tggagcgtac gcacgagacg cgcacggcgg ccggtatcga ggccggtgag gcggtgcgcg 9061 cgcaggccga ccggacgctg ctggcctcca tcggcaagcg ctcggcgcag cgcgccacgg 9121 ccgcggacgc ggacgccacg tacgcagcgt gcaggctggt cgcccgcgcc gccgggatcc 9181 cgctggccga accggccctg ggcggcaccg agagcgaccg gctcgacccg gtggagcgca 9241 tcgcgctcgc ctctcgggtg cgcaccaggt cggtgcggct ggcggaccgc tggtggcggg 9301 aggacgtggg gccgctggtc gggcaccgca ccctgtccgg ggcgccggtg gcgctgctgt 9361 ggcggcgcgg cggctatgcg gccgtgcatc cggcgaccgg tcgtgagacg ccggtggagc 9421 gggcgaacgc cggggagttc gagccgcgcg cggtgatgtt ctaccggccg ctgccggagc 9481 ggcggctcag tccgctgcga ctgctgcggt tctgtctggc gggcacgcgc cgggatctga 9541 ccggtctgct gctcgccggt ctggtgacgg tggcgctcgg cgcgctggtg ccgatcgcga 9601 cgggccgggt gctcggcgag ttcgtgccga aggcgcagac cgggctgatc gtgcaggtgt 9661 gtctcgcggt gatgctgagc agtgtcgtcg cggccgcctt catgctgctc cagaacctca 9721 ccatcctgcg tctggagggc cggatcgagg cgacgctcca gcccgccgtg tgggaccggc 9781 tgctgcggct gccgacgaag ttcttcaccg agcgctccac cggcgagctg gcgagcgcgg 9841 ccatgggcat cagcgcgatc cgcaggctcc tcgcgggcgt cggtccgacg gtcgcccagt 9901 cggtgacggt cggggcgatg aacctgggcc tgctgctctg gtacagcgtg ccgatggcgc 9961 tcgcggcgat cggcatgctg gtggtggtcg ccggggtctt cctggggctc gggctgtggc 10021 aggtgcgctg gcagcggcgg ctggtcaagc tcaccaacaa gctgaacaac caggcgttcc 10081 agacgctgcg cggactgccc aagctgcggg tggcggcggc cgagaactac gcctacgcgg 10141 cgtgggcgga gcggttcgcg cacagccggg agttgcagca gcgggcgggg cggatcaaga 10201 acctgaacgc ggtgct //