LOCUS       NZ_KZ195572            22214 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS057 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195572
VERSION     NZ_KZ195572.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS057
  ORGANISM  Streptomyces sp. CS057
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 265.32x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188345.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:40:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,152
            CDSs (total)                      :: 7,074
            Genes (coding)                    :: 6,991
            CDSs (with protein)               :: 6,991
            Genes (RNA)                       :: 78
            rRNAs                             :: 10, 6 (16S, 23S)
            complete rRNAs                    :: 10, 6 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 23 of 83
            Pseudo Genes (incomplete)         :: 71 of 83
            Pseudo Genes (internal stop)      :: 4 of 83
            Pseudo Genes (multiple problems)  :: 14 of 83
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:25:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8218233
            Orig. end                         :: 8240447
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..22214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="35"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22214
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12214](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12214)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1446..3068)
                     /locus_tag="B9W61_RS35115"
                     /old_locus_tag="B9W61_35085"
     CDS             complement(1446..3068)
                     /NRPS_PKS="Domain: AMP-binding (8-438). E-value: 6.3e-66.
                     Score: 214.5. Matches aSDomain:
                     nrpspksdomains_B9W61_RS35115_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956445.1"
                     /locus_tag="B9W61_RS35115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35085"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_087767588.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-69, bitscore:
                     232.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDAVPDREALLYVDHPGTGAERRLTYAELDAAA
                     NRIAHHLIDAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYR
                     DADLAALVFDGEFDERVSAAAPQAPGLRHLVRVGPAPAAPPGVPVVPFTEAERSGGSGR
                     GFAPRSADDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKAPRELAERVAA
                     GGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPAEVLRTIEKEKVTSVSLVG
                     DAMLRPLIDCLKGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSES
                     GFNGTATADSGPERGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPAK
                     TADTFFRRGEERWVLLGDMATVDADGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPD
                     VYDALVAGVPDERWGNRVAAVVQLREDTAALTLEAVQAHCRTRLAGYKIPRALVLADRI
                     QRSPSGKADYRWAKAVAAGAHRD"
     aSDomain        complement(1755..3044)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS35115_AMP-binding.1"
                     /evalue="6.30E-66"
                     /label="B9W61_RS35115_AMP-binding.1"
                     /locus_tag="B9W61_RS35115"
                     /protein_end="438"
                     /protein_start="8"
                     /score="214.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDAVPDREALLYVDHPGTGAERRLTYAELDAAANRIAHHLI
                     DAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYRDADLAALV
                     FDGEFDERVSAAAPQAPGLRHLVRVGPAPAAPPGVPVVPFTEAERSGGSGRGFAPRSAD
                     DQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKAPRELAERVAAGGDGITFF
                     PTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPAEVLRTIEKEKVTSVSLVGDAMLRPLI
                     DCLKGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESGFNGTATA
                     DSGPERGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPAKTADTFFRR
                     GEERWVLLGDMATVDADGIVTVLGRGSQCIN"
     CDS_motif       complement(1857..1904)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W61_RS35115_0002"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="B9W61_RS35115"
                     /protein_end="404"
                     /protein_start="388"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     CDS_motif       complement(2499..2549)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W61_RS35115_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="B9W61_RS35115"
                     /protein_end="190"
                     /protein_start="173"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     misc_feature    3146..3159
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(3162..3176)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     misc_feature    complement(3164..3180)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(3166..3181)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     gene            3235..4035
                     /locus_tag="B9W61_RS35120"
                     /old_locus_tag="B9W61_35090"
     CDS             3235..4035
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 3.5e-53. Score:
                     172.3. Matches aSDomain:
                     nrpspksdomains_B9W61_RS35120_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="B9W61_RS35120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35090"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_047175003.1"
                     /transl_table=11
                     /translation="MGGTEHLTVRREGATLVLTLNRPQARNALSLPMLVGLYDGWLAAD
                     ADDTVRSVVLTGAGGAFCAGMDLKALAGGGMEGERYRERMTADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRPYTAEEAAAIGLVGRVVPDGTALEEALVVAERVNACGPLAVEAVKASVYE
                     GAELTESEALAAELKRGWPVFATEDAKEGARAFAEKRPPVYRRA"
     aSDomain        3262..4008
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS35120_ECH.1"
                     /evalue="3.50E-53"
                     /label="B9W61_RS35120_ECH.1"
                     /locus_tag="B9W61_RS35120"
                     /protein_end="258"
                     /protein_start="9"
                     /score="172.3"
                     /tool="antismash"
                     /translation="RREGATLVLTLNRPQARNALSLPMLVGLYDGWLAADADDTVRSVV
                     LTGAGGAFCAGMDLKALAGGGMEGERYRERMTADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     PYTAEEAAAIGLVGRVVPDGTALEEALVVAERVNACGPLAVEAVKASVYEGAELTESEA
                     LAAELKRGWPVFATEDAKEGARAFAEK"
     misc_feature    3284..3298
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            4094..5050
                     /locus_tag="B9W61_RS35125"
                     /old_locus_tag="B9W61_35095"
     CDS             4094..5050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="B9W61_RS35125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35095"
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_087767589.1"
                     /transl_table=11
                     /translation="MSDVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTEDGTV
                     LVPPVEYDPVTANEIRDLVEVAPTGTVTTWAWNPSPGRDQPLPTPFAWVLVRLDGAGTA
                     LLHVLDAPGPDAVRTGMRVRIRWAATRTGAITDIACFEPYEGEPGHCEPAPHPGEFAEP
                     VTGIVTPARLDYVHTPGRAQSAYIKALEERRTVGERCPACRKVYVPPRGACPTCGVATA
                     EQVEVGPRGTVTTFCIVNIKAAHTANLDIEVPYVYAHIALDGADLALHGRIAGIPYDQV
                     RMGLRVEPVWTEGARHVDHYRPSGEPDADYDTYKELV"
     gene            5051..6103
                     /locus_tag="B9W61_RS35130"
                     /old_locus_tag="B9W61_35100"
     CDS             5051..6103
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515105.1"
                     /locus_tag="B9W61_RS35130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35100"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_087767590.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSVHRRRTDELSEVDLLMPVLHEVLGTTGLKANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKIQTGEADTA
                     LVYSYGKSSPGRVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGVTDEGALCEVA
                     ARNRTAAADNPYAQLTGDVPAGDHLVRPLRTGDCPPIGDGAAAVVLAAGDTARALCARP
                     AWIRGIDHRIEAHALGVRDLTDSPSARLAAERAGAFERPVDTAELHAPFTSQEVILRKA
                     LGLGDEVRVNPSGGALAANPVMAAGLIRLGEAAARIHRGESDRALAHATSGPCLQQNLV
                     AVLEGESAHV"
     gene            6096..7262
                     /locus_tag="B9W61_RS35135"
                     /old_locus_tag="B9W61_35105"
     CDS             6096..7262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="B9W61_RS35135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35105"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_087767591.1"
                     /transl_table=11
                     /translation="MSKEPVAVVGIGQTKHVAARHDVSIAGLVREAAVRALEDAGLTWS
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDAVGS
                     LVAYKDRRNALKNPYAHLHDHDITLEKVRAAPMLWDPIRYSETCPSSDGACAMILTDRE
                     GAARSPHPPAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFAEEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGEHQIDGATRALGHAYGGGAQFFAMWLVGAEPPPG"
     misc_feature    complement(7325..7335)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            7338..7838
                     /locus_tag="B9W61_RS35140"
                     /old_locus_tag="B9W61_35110"
     CDS             7338..7838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="B9W61_RS35140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35110"
                     /product="hypothetical protein"
                     /protein_id="WP_003971159.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEEGQVPFEVAQLLLALENDEPIEVVSSEDV
                     PVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     misc_feature    complement(7970..7984)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            8052..9311
                     /locus_tag="B9W61_RS35145"
                     /old_locus_tag="B9W61_35115"
     CDS             8052..9311
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458464.1"
                     /locus_tag="B9W61_RS35145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35115"
                     /product="MFS transporter"
                     /protein_id="WP_087767592.1"
                     /transl_table=11
                     /translation="MANPYGVLFRTPGSRAFTAAGFVARMPLSMAGIGIIAMVSQMRGD
                     YGLAGAVSATFTLSMALCGPRISRAVDRRGQSRVLPPVAGLSVMALGALLLCARYDAPA
                     WTLFGCAAVAGAMPNMAAMVRARWTHALKGSDRLHTAYSLESVVDELTFVVGPALSVAL
                     CTALFPEAGPLVAGVLLVLGVLMFVPQKRTEPPVLRPADGHPRTGSAIRSGALRLLALT
                     LVAGGAIVGTVDVVSVSFAEQQGSPAGAGIVLSVYAAGSAVAGLVFGTLRLRTPLPRLL
                     VLGTAGTALTTLPLLLVGDLVTLSAAVFLPGLFFAPTMIVVMGLVERTVPPAVLTEGMT
                     WAITGLSVGVASGAAVSGAIVDRFGPDGGFVVAVAAGATALLTALCARRPLERSLRERA
                     DRDAERPAEASAEAPGSAAH"
     gene            9367..9924
                     /locus_tag="B9W61_RS35150"
                     /old_locus_tag="B9W61_35120"
     CDS             9367..9924
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956439.1"
                     /locus_tag="B9W61_RS35150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35120"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_047174998.1"
                     /transl_table=11
                     /translation="MHTPQTDGRLLKGERRKEELIEATLQVVAREGVAGVSHRAVAREA
                     GLPATAAAYHFTSIDDLLTAALTRCMEQDARRMLRLAEEADGGPEGVTALAELMEKVVK
                     GPGRLLAEYELYLLAARRPELRAPTRHWLEAIAAYGHRYTDDPVRVRVLKGVIDGLLLQ
                     GLLTDTPPTAAEFEAVLRHVLL"
     gene            complement(10001..12214)
                     /locus_tag="B9W61_RS35155"
                     /old_locus_tag="B9W61_35125"
     CDS             complement(10001..12214)
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956438.1"
                     /locus_tag="B9W61_RS35155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35125"
                     /product="terpene synthase family protein"
                     /protein_id="WP_087767593.1"
                     /sec_met_domain="T1TS (E-value: 4e-85, bitscore: 285.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHVEAARTHTRAWARSMGMLEGSGIW
                     EEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGGKRY
                     LDRLPAFMPMERGAPTPEPENPVEAGLADLWARTIPSMSDAWRARFAEATENLLNESLW
                     ELANIHEGRIANPVEYIEMRRKVGGAPWSAGLVEYAANAEVPAPVADARPLRVLRDAFS
                     DAVHLRNDLFSYQREVEEEGENSNGVLVLEKFLGCSTQEAAEAVNDLLTSRLQQFENTA
                     LTELGPLCAEKSLDPTQTAAVLAYVKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGFG
                     MSAASIRFTLRSETSRVRGQSHVPYQRVGPSLLPSFDLPFGTTLSPHLEGARVRIVDWA
                     RRMGILEAQPGVPGSSIWDERRIVAIDLPLCAAGIHPDATPDELDLSSGWLAWGTYGDD
                     WFPVVHGRTRDLAGARLANERLSLFMPLDGEGTPEPVNALERGLDDLWRRTAGPMDADG
                     RRTFRASIESMTESWLWELANQAQNRIPDPVDYVEMRRATFGSDLTMSLCRLGHGRKVP
                     DEVYRSGPMRSLENAAADYACLMNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVA
                     IVHDLMNARLRQFLHVAEVELPVLYDDFALDAEAREILAGYVRELEHWIAGILIWHRGC
                     RRYREEDLRRGHGTPWHISGPTGLGTSAAQITRLLTQLAGSPA"
     gene            complement(12422..13096)
                     /locus_tag="B9W61_RS35160"
                     /old_locus_tag="B9W61_35130"
     CDS             complement(12422..13096)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="B9W61_RS35160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35130"
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_087767594.1"
                     /transl_table=11
                     /translation="MPRISTLRITRSHKIATAVLVAAGSVSAIAATGGTSEAQTTATRS
                     SISVEPVAAAGIPTAKDAAAKKAAQETAAKEAAAKKAVAARKATAEKDAAEARAEKQAA
                     NRSTERKAVTPKKFANNLDGWIRESLDIMKKKNIPGSYEGLHRNIMRESSGNPNAVNDW
                     DINAQNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDPVANITAAANYAADRYGSIDNVDS
                     AY"
     gene            complement(13573..14709)
                     /locus_tag="B9W61_RS35165"
                     /old_locus_tag="B9W61_35135"
     CDS             complement(13573..14709)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="B9W61_RS35165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35135"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_047174995.1"
                     /sec_met_domain="APH (E-value: 7.7e-17, bitscore: 60.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRPMGAGGGPYLAPHAGAPVQGPGRARRAAG
                     PGTGPLSGRIDLSGPQGAQVRMAIASVQRICPEFNPVQVLRRSGRSVLIVGTTGRATAV
                     AKCLLDHSPAWTERFRHEIAAYRAFVRHRPPVRAPRLIAADPENCTLVIERMPGRVAAL
                     TRHPAEAPPRADIRAALGAIARVNAWRPPPGLFEAPLDYASRIARYHELGLFTDRDLGD
                     LQKLLHGLAHAGGRQGMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWA
                     VLGDAPAARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPAAGAG
                     ADRPGALSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    complement(14386..14388)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14941..16431
                     /locus_tag="B9W61_RS35170"
                     /old_locus_tag="B9W61_35140"
     CDS             14941..16431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606686.1"
                     /locus_tag="B9W61_RS35170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35140"
                     /product="hypothetical protein"
                     /protein_id="WP_087767595.1"
                     /transl_table=11
                     /translation="MTGEPNTRLSDLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRVGKRRDSGTEHHPDQL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSTIAGPMYDWLHSDPAPMADAPR
                     AGDALHADPAGLDRYEAAPVGSEEIEALEHSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGDETLPRTQAMLRTIEAWAQASMGRGQA
                     MRRTLGEAEELFVSDKSDVPPPSWMQMFDEADMHGMQALAFRTLAEHDQGAAIIAQRHA
                     KQALELRVNGRQRSKIFDYISLASACFIANDPDQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQFAGYPGIQDLREEIELSMPPSQKKAKGTPA"
     misc_feature    14983..14998
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.26"
                     /tool="antismash"
     gene            complement(16482..17909)
                     /locus_tag="B9W61_RS35175"
                     /old_locus_tag="B9W61_35145"
     CDS             complement(16482..17909)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="B9W61_RS35175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35145"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_087767596.1"
                     /transl_table=11
                     /translation="MPSPHFADRPAPQLPAHDAVDALIHRTRRLRGDVDAVRRDTVVLD
                     EDDPQLRWQRALCELAVQHLDSLDQHLGQLRAGLPDRSADDAPRAVGAPDDPRAGSLLN
                     RVGSAEWNLLTDESSWSEELYEIFGRPPGSTPLSLDDLPSVLLPEDQPVLTAMVTGCLV
                     DGRPMDGEFRIVRPDGRTRTVHMTGEPVLDAEGCTASMWAVLRDVSELRRSERAVSRDR
                     ASVRREEHIERTEHRMAVELQEAVLPPWRGSLRLPSQGPGALDVAAHYLPSESSGLIGG
                     DWYDAMELPDGRTLLTVGDLTGHGIPATSAMAMMLGALRGMAVAGIEPGALMGHLNQVL
                     ETSVQPALGSALCCRFDPDTSILSWAQAGHPAPLLFRHGSGRLLPPPDGMLLGAASNVV
                     FEQDEVRLYPGDVLVLHTDGLTRRGDRGAGPEALFALAPRFADARTAQECVRSVVEEFG
                     GAERLDDACVLVARIGA"
     misc_feature    complement(18063..18078)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.28"
                     /tool="antismash"
     misc_feature    complement(18160..18174)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    18161..18172
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     misc_feature    complement(18161..18176)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            18220..18384
                     /gene="rpmG"
                     /locus_tag="B9W61_RS35180"
                     /old_locus_tag="B9W61_35150"
     CDS             18220..18384
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192346.1"
                     /locus_tag="B9W61_RS35180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35150"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_032794160.1"
                     /transl_table=11
                     /translation="MARSETRPVVTLRSTVGTGRSYVTRKNRRNNPDRLELRKFDSAAG
                     RHVLFREVR"
     gene            18449..18709
                     /locus_tag="B9W61_RS35185"
                     /old_locus_tag="B9W61_35155"
     CDS             18449..18709
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606682.1"
                     /locus_tag="B9W61_RS35185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35155"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_087767597.1"
                     /transl_table=11
                     /translation="MKSRIHPVSRPVVFRDRAADVAFLTRSTADSGERVTWQDGNSYPV
                     IDVDTSSASHPFYTGGSQVLDTAGRVERFRRRYGTGETSGS"
     gene            complement(19018..19518)
                     /locus_tag="B9W61_RS35190"
                     /old_locus_tag="B9W61_35160"
     CDS             complement(19018..19518)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="B9W61_RS35190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35160"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_087768108.1"
                     /transl_table=11
                     /translation="MSAHKKRDLLDEADRLRSEGRPEEAREQLLALTARYPDDAEVAYR
                     TAWIHDVLGLESEAVPYYERALAHPELASEDRRGALLGLGSTYRVLGRYGQAVETLRRG
                     VEEFPDDGSLRAFLAMALYNTDEHHEAMRLLLELTAATSQDPHVQQYRRAMEHYAKDLD
                     ETV"
     gene            19619..20456
                     /locus_tag="B9W61_RS35195"
                     /old_locus_tag="B9W61_35165"
                     /pseudo=""
     CDS             19619..20456
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458443.1"
                     /locus_tag="B9W61_RS35195"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35165"
                     /product="VanZ family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAEANPRTDRGTWVRVLVRGAVLTVVLLGLVAFSVLLAKVTLTP
                     SPASADLVTANLRPGRSLRQYAEDYTFLAACKQAGGNLLLGVPFGLLLPFFVPRRLRMI
                     RTTLLTAVAMAVVELIQGALVEGRAFDIDDVILNTAGALLGYFVLGRRISHRYYTYTDD
                     SVSPGPSAEKPGAELKRAPGPSARTKTARTGAGAVHSLLDRLRGR"
     gene            20357..21154
                     /locus_tag="B9W61_RS35200"
                     /old_locus_tag="B9W61_35170"
     CDS             20357..21154
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458442.1"
                     /locus_tag="B9W61_RS35200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35170"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_087767598.1"
                     /transl_table=11
                     /translation="MAEGQWSPGRKEADADEFRPVLDIVEPARQRRLTVLLRLLLLIPH
                     FVVLFVLHIAAFFTVIVGWFAALVLGRLPDSVFRFLTGVLGYDMRVSASDMLLIDRYPP
                     FALTPPADYPVRIEVRPTPLNRLAVLFRFFLMIPAAIVQSLAVYGWWALAFVWWLITLC
                     LGRMPRPLFEATAATLRYRMRFSAYVMMLTPAYPKGLFGDDDLAVAPERARSATRPLVL
                     SSAAKWLVVLFLVLGLAGHVISSVTASTTDDIDDTYDTRLVGP"
     gene            complement(21127..22149)
                     /locus_tag="B9W61_RS35205"
                     /old_locus_tag="B9W61_35175"
     CDS             complement(21127..22149)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956427.1"
                     /locus_tag="B9W61_RS35205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_35175"
                     /product="YafY family protein"
                     /protein_id="WP_087767599.1"
                     /transl_table=11
                     /translation="MPKTSARLLALLSLLQARRDWPGRLLAERLEVSPRTVRRDVDRLR
                     ELGYPIAAFKGPDGGYRLDAGAQLPPLLFDDDQAVALAVALRTAAATGAGIGEAAARAL
                     TTVRQVMPARLRHRVDALRVTAVERTGGPPRPQADPRVLVTLSAAVHAREVLRFDHSPA
                     YAAPSAEAPPAVRRVEPHRLVTWGGRWYLVAWDLDREDWRTFRADRITPRTPTGPRFAP
                     REVPGGDVAAFVAARFQGSGAPGEWPCRGEVILDAPASAVAGHIRDGSVEEHGPDRCRV
                     VLGAWSWAGLAAELGRFDVDIEVVGPDALRDAFALLARRCAAAAGAGPGGPQGPTSRVS
                     "
ORIGIN
        1 tctccgcggc accggcgact ccggtgttcc cgaggacccc tcgacgtacc gctgcgacca
       61 cctggtcgac gacgtggaag cactgcgcga acacctgggc ctcgaccgga tcgacgtact
      121 ggcgcactcc gccggggccg accttgccct gctgtacgcg gcccgccacc cggaccggct
      181 gcgccgactg gccctcgtca cgcccagcac ccgggccgtg ggcatcgaga tcagcgacca
      241 ggacctgcgc gaggccgccg agctgcggcg tgacgagccc tggtaccccg aggccagggc
      301 cgcccaggag gcgctgctcg ccggcgggcc gttcgccgag ctgtggcccg ccgtccggcc
      361 cctcacctac ggccgctggg acgcgaccgc ccgtgcccac gccgaggcgt ccgccgggca
      421 gaccaacgcg gaggcgcgcg gccactacgc cggggacggg gccttcgacc ccgccgccac
      481 cgccgccgcc ctgcgcgggc tgaccgtgcc ggtcctcgtc ctcgccgggg agtacgacgg
      541 agacccgagc ccggaccggg ccacggagct cgccgcgctc ttccccggcg ccgagttcgt
      601 cgtccagcgg ggcgccgggc acttcccgtg gctggacgac ccgggagcct tcacccgtgc
      661 ggtggcggcc ttcctcgacc cggacgtccg tacggtgcag gcgggcgggg tccggctggc
      721 gtaccgggtg tggggcgagg aggccgcccc gcccgtcgtc ctcctgcacg ggcgggccgg
      781 ctccagtgag acctggaccc ggatcgcgga ggacctggcc gccgaccacc gcgtgtacgc
      841 ccccgacttc cggggccacg ggctgagcga ctggcccggc cgctactcct tcgagctgtt
      901 ccgcgacgac gtgcacgcct tcctggaggc ccgcaacctg gccggcgcga ccgtcgtcgg
      961 gcactccatg ggcggggtgg ccgcctacct cctggcccag cgggaaccgg gcctgatcgg
     1021 acgcctgatc gtcgaggacg cgccgcccct ccacccgctc gacccgcccc ggccgccctc
     1081 cgtccgcccg gagggcacgc tcgacttcga ctggtccgtc gtccccgaca ccgacgtcca
     1141 gctgggcgac cccgacccgg ccgtccggag ccggttcccg gagatcaccg cgcccaccct
     1201 cgtcatcggc ggcggcccca ccagccacat cgaccaggga cacctcgcgg agatggtccg
     1261 ggcgataccg gacgccgagc tggtcaccgt cgacgccgga catctgatcc acacggacag
     1321 gcccgcggaa ttcctggcgg cgatcaggga gttcggcctc ggcacgcgga aaggggacgg
     1381 cgctcgctga gcgcggggcg gctccggacc gggacgtccc gcccggtggc ggaccacgcc
     1441 cccgctcagt cccggtgcgc ccccgccgcc accgccttcg cccaccggta gtccgccttg
     1501 ccgctcggcg agcgctggat ccggtcggcg agtaccagcg cgcgggggat cttgtagccg
     1561 gcgagccggg tccggcagtg cgcctgcacc gcctccagcg tcaatgccgc cgtgtcctcc
     1621 cgtagttgga cgacggcggc gacccggttg ccccagcgct cgtcgggtac gcccgcgacg
     1681 agcgcgtcgt acacgtccgg gtgggacttg agcgcctgct cgacctcctc cggatacacc
     1741 ttctcgcccc cggtgttgat gcactgggag ccccggccga gcacggtgac gatgccgtcc
     1801 gcgtccacgg tcgccatgtc gcccagcagt acccaccgct cctcgcccct gcggaagaag
     1861 gtgtcggcgg tcttggccgg gtcgttgtag tagccgagcg ggacatgacc gcgctgggcg
     1921 atacggcccg gctcgccggg ggccaccggc tcgtacgtca ccggatcgac cacggccgta
     1981 cgggcgttga cctggacccg gaagccacgt tccgggcccg agtcggccgt cgccgtgccg
     2041 ttgaaaccgg actccgagga gccgaagttg ttcagcagca tcacggtcgg cacgagcgcc
     2101 tggaactccg cccgcaccga gtccgacatg atggccccgg agctggagac ggagaacagc
     2161 gacgagcagt ccgtcccgcg cagcggcccc ttcaggcagt cgatcagcgg gcgcagcatc
     2221 gcgtcgccga ccagcgacac actggtgacc ttctccttct cgatcgtccg cagcacctcg
     2281 gcgggcacga acttgcggtg cacgacgacg cgttggccga agttgaagcc gatgaacgcg
     2341 gtcagcgtgg aggtcccgtg catcagcggc ggggtgggga agaaggtgat cccgtcccct
     2401 cccgcggcga cccgctccgc cagctcccgc ggggccttca ccggctcgcc ggtcggtgct
     2461 ccaccgccca ggcccgagaa gaacaggtcc tcctggcgcc acatcacgcc cttcggcatg
     2521 ccggtcgtgc cgccggtgta gatgatgaac tggtcgtcgg cggagcgggg ggcgaagccg
     2581 cgcccggacc cgcccgacct ctccgcttcg gtgaacggca cgacgggcac gcccggggga
     2641 gcggcgggtg cgggccccac ccgcaccaga tggcgcaggc ccggggcctg cggggcggcc
     2701 gccgagaccc gctcgtcgaa ctcgccgtcg aagacgagtg ccgccaggtc cgcgtcccgg
     2761 tagagataga ccaactcttc ttcgacgtag cggtagttga cgttcaccgg gacaatccgc
     2821 gccttgaggg cgcccaggac cgtctggagg tattcgaccc cgttgtagag gtgcagcccc
     2881 aggtgctcgc ccggccggat ccccgcgtcg atcagatggt gggcgatccg gttggcggcg
     2941 gcgtccagct ccgcgtacgt gagccgtcgc tccgcgcccg tgccgggatg gtcgacgtac
     3001 aggagcgcct cgcggtcggg aaccgcgtcg acgaccgact cgaacaggtc ggcaaggttg
     3061 tattccaccg ttcctcctga ccccgggtga ctggcgactc ggccgtcatt agagcgccgg
     3121 gcggcacaag tgggaagggg tggcgtcgaa agaatctgac gagctgtcag aaaactattg
     3181 aactgcgccc cctcctcctg caacctgttc caggtctgga gacaggagtc ggtcatgggc
     3241 ggtacggaac atctcaccgt gcggcgcgaa ggcgccacgc tggtactcac cttgaacaga
     3301 ccacaggcca ggaacgcgct ctcgctgccg atgctcgtcg gtctgtacga cggctggctc
     3361 gcggccgacg cggacgacac ggtccgctcc gtcgtcctga ccggagccgg cggcgcgttc
     3421 tgcgccggaa tggacctcaa ggccctggcg ggcggaggaa tggaggggga gcggtaccgg
     3481 gagcggatga cggccgaccc cgacctccac tggaaggcga tgctgcgcca ccaccggccg
     3541 cgcaaaccgg tgatcgccgc cgtggagggc ccctgtgtcg cgggcggcac cgagatcctg
     3601 cagggcaccg acatccgcat cgccggagcg ggagccacct tcgggctctt cgaggtccgc
     3661 cggggcctct tcccgatcgg cggctccacg gtccggctgc cccgtcagat cccccgtacc
     3721 cacgccctcg aaatgctcct caccggccgc ccgtacaccg ccgaggaggc cgccgccatc
     3781 gggctcgtcg gcagggtcgt gcccgacggc accgcgctgg aggaagcgct cgtcgtcgcc
     3841 gaacgggtca acgcctgcgg gccgctggcc gtcgaggcgg tcaaggcctc ggtctacgag
     3901 ggtgcggagc tgacggagag cgaggcgctg gccgccgaac tcaagcgcgg ctggcccgtg
     3961 ttcgccaccg aggacgccaa ggagggcgcg cgggccttcg ccgagaagcg accgcccgtc
     4021 taccggcgcg cctgagttcc gagcccgccc ctgagccctg agccctgagc cccgagtcaa
     4081 ggaggctgta gccatgtccg acgtcctcag cgccccgctg gtggtcgaat tccccttcac
     4141 ccgctcgctc gggcccgtcc agagcgcctt cctcaccgga ctgcgcgaac gcaccgtact
     4201 cggcgtccgc accgaggacg gcacggtgct cgtgcctccc gtggagtacg accccgtcac
     4261 cgcgaacgag atccgcgacc tcgtcgaggt cgcccccacc ggcaccgtca ccacctgggc
     4321 ctggaacccg tccccgggcc gcgaccagcc gctccccacc cccttcgcct gggtgctcgt
     4381 ccgcctcgac ggggccggca ccgcactcct gcacgtgctc gacgcgcccg gcccggacgc
     4441 cgtgcgcacc gggatgcgcg tccgcatccg ctgggccgcg acgcgcaccg gagccatcac
     4501 cgacatcgcc tgcttcgagc cgtacgaggg cgagcccggc cactgcgaac ctgctcctca
     4561 cccaggggag ttcgccgaac ccgtcaccgg catcgtcacc ccggcccgcc tcgactacgt
     4621 ccacaccccc ggccgcgccc agagcgccta catcaaggcc ctggaggaac gccgtaccgt
     4681 cggcgaacgc tgccccgcct gccgcaaggt ctacgtaccg ccgcgcggcg cctgccccac
     4741 ctgcggggtc gccaccgccg aacaggtcga ggtcggacca cgcggcacgg tcaccacctt
     4801 ctgcatcgtc aacatcaaag ctgctcatac ggcgaatctc gacatcgaag tcccgtacgt
     4861 atacgcccac atcgccctcg acggcgccga cctcgccctg cacggacgca tcgccggaat
     4921 cccctacgac caggtccgca tgggcctgcg cgtcgagccc gtctggaccg agggcgcccg
     4981 ccatgtcgac cactaccggc ccagcggcga gcccgacgcc gactacgaca cgtacaagga
     5041 gctggtgtag atgcgggacg tggccatcgt cgccttcgcc cagagcgtgc accggcggcg
     5101 caccgacgaa ctctccgagg tcgacctcct gatgcccgtc ctccacgagg tcctgggcac
     5161 gaccggcctc aaggcgaacg agatcgggtt cacctgctcc ggctccgccg actacctcgc
     5221 cggacgggcc ttctccttca ccatggcgct cgacggcgtc ggggcgcatc cgcccatctc
     5281 cgagtcccac gtcgagatgg acggggcctg ggcgctgtac gaggcgtggg tgaagatcca
     5341 gaccggcgag gcggacaccg cgctcgtcta ctcctacggc aagtcgtccc ccggccgggt
     5401 ccgcgacgtc ctcacccgcc agctcgaccc ctactacctc gccccgctct ggccggactc
     5461 cgtcgcgctc gccgccctcc aggcgcaggc cctcatcgac gccggcgtca ccgacgaagg
     5521 agccctctgc gaggtcgccg cccgcaaccg caccgcagcc gccgacaacc cgtacgccca
     5581 gctcaccggc gacgtccccg cgggcgacca cctggtgcgg ccgctgcgca ccggcgactg
     5641 cccgcccatc ggcgacggcg cggccgccgt ggtcctcgcc gccggggaca ccgcccgcgc
     5701 cctgtgcgcg cgccccgcct ggatccgcgg catcgaccac cggatcgagg cgcacgccct
     5761 cggcgtccgc gacctcaccg acagcccctc cgcgcggctc gccgcagagc gcgccggggc
     5821 cttcgaacgg ccggtcgaca cagccgagtt gcacgccccg ttcacctccc aggaggtcat
     5881 cctgcgcaag gcgctcggcc tcggcgacga ggtccgcgtc aacccttcgg gcggtgcgct
     5941 cgccgccaac cccgtgatgg ccgccgggct gatccggctc ggcgaggccg ccgcccgcat
     6001 ccaccggggc gagtccgacc gggcgctcgc gcacgccacc tccggcccct gcctgcaaca
     6061 gaacctggtc gccgtactgg aaggggagag cgcccatgtc taaggagccc gtcgccgtcg
     6121 tcggcatcgg ccagaccaag cacgtcgccg cccggcacga cgtgtccatc gccgggctgg
     6181 tccgcgaggc cgccgtccgg gcactggagg acgccgggct gacctggagc gacatcgacg
     6241 ccgtcgtgat cggcaaggcg cccgacttct tcgagggcgt catgatgccg gagctctacc
     6301 tcgccgacgc cctgggcgcc gtcggaaagc cgatgctgcg cgtccacacg gcgggatcgg
     6361 tcggcggatc gaccgcgctg gtcgccgcca acctcgtcgc cgcccgagtg caccggaccg
     6421 tcctcaccct cgccttcgag aagcagtccg agtccaacgc catgtgggga ctctcgctgc
     6481 ccgttccctt ccagcagccg ctgctggctg gagcgggcgg tttcttcgcc ccgcacgtgc
     6541 gggcgtacat gcgacgcacc ggagcgcccg acgcggtcgg atcgctcgtc gcgtacaagg
     6601 accgccgcaa cgcgctgaag aacccctacg cgcacctcca cgaccacgac atcaccctgg
     6661 agaaggtccg ggccgccccc atgctctggg acccgatccg ctactccgag acctgcccct
     6721 cctccgacgg ggcctgcgcc atgatcctca ccgaccggga gggcgcggcc cgctcgcccc
     6781 acccgcccgc ctgggtccac ggcggggcga tgcggagcga accgaccctg ttcgcgggca
     6841 aggacttcgt ctccccgcag gcggggaagg actgcgcggc cgacgtctac cggcaggccg
     6901 ggatcaccga cccgcgccgg gagatcgacg ccgtcgagat gtacgtgccg ttctcctggt
     6961 acgagccgat gtggctggag aacctcggct tcgccgagga gggcgagggc tggaagctca
     7021 ccgaggcggg cgtcaccgag ctcgacggcg acctcccggt caacccttcg ggcggtgtgc
     7081 tctccaccaa tcccatcgga gcgtccggca tgatccgctt cgccgaggcg gctctccagg
     7141 tgcgggggag ggccggggag caccagatcg acggggccac cagggcgctc ggccacgcct
     7201 acggcggagg ggcgcagttc ttcgccatgt ggctcgtcgg agcggagccg ccgcccggct
     7261 gagggaatgc gcccggcccg gtcccgcggg gccgggcccg gctccgcaac gtgagccggg
     7321 acacgtaaca tggcagcatg tccttcctcc gccgccgtag cgccgcaaca cccgcgggcc
     7381 cggacttcga cgtcctggcc atggaccccg gggactggcc gggcaacctc ggcgccggtc
     7441 tgctccccgc ccccgacggc agctgtcagg gcgtcttcct ccgttacgac ctgtacggcg
     7501 gccggggccc ggcgatgatc atcggcaatc tcccggaagg ctcgcccgca cgcgagaccg
     7561 aggagggcca ggtccccttc gaggtggccc aactgctcct cgccctggag aacgacgagc
     7621 ccatcgaggt cgtcagctcc gaggacgttc ccgtcatgca gggcgacaat ctgctgatcg
     7681 tccgccgcgt caagctctcc gagagccgta tcgcctgcgt ccagttcgat cgcagcgacg
     7741 gtgtcctcgt gaccatcgcc agctgggacc ggccgatcac cgacgacctg tacaccctgc
     7801 tcaagcccct gcccgcagag ctgttccagc agggctgaaa cgtccctgcg caaggccgcc
     7861 cggatccgtc cgggcggcct tttccgttgt ccggggaggg gatccggcca ttccccgagc
     7921 ccgggtcggc ggcggtccgg gggagggcta aggtagaaaa cgaaacgact gttcaaattg
     7981 aagcgatcgt tcaagttcga cggtcgcgcc atgcgaaggg tcgcccgtac gtctcctccg
     8041 gaggtccgcg catggccaac ccctacggcg tcctgttccg gacgcccgga tcgagggctt
     8101 tcaccgccgc cgggttcgtc gcccgtatgc ccctgtcgat ggcgggcatc ggcatcatcg
     8161 cgatggtgtc ccagatgcgc ggtgactacg gcctggccgg agccgtctcc gccaccttca
     8221 ccctgtccat ggccctctgc ggtccgcgga tctcccgcgc ggtcgaccgc cggggccaga
     8281 gccgggtgct gccgcccgtc gccgggctga gcgtcatggc gctcggcgcg ctgctgctct
     8341 gcgcccggta cgacgccccc gcctggaccc tgttcggctg cgcggcggtg gccggcgcga
     8401 tgccgaacat ggcggcgatg gtgagggccc gctggaccca cgccctcaag ggctccgacc
     8461 ggctgcacac cgcctactcg ctcgaatcgg tcgtcgacga actcaccttc gtcgtgggcc
     8521 ccgcactctc ggtggccctg tgcaccgcac tgttccccga ggccgggccg ctggtcgccg
     8581 gggtgctgct ggtgctcggc gtcctcatgt tcgtcccgca gaagcgcacc gaacctccgg
     8641 tgctccggcc ggccgacggt cacccgcgca ccggctcggc gatccgcagc ggagcgctcc
     8701 gtctgctggc cctcacgctc gtggccggcg gcgccatcgt cggcaccgtc gacgtcgtga
     8761 gcgtctcgtt cgccgaacag cagggctcac ccgccggcgc gggaatcgtc ctctcggtct
     8821 acgcggccgg atccgccgtc gccgggctgg tcttcgggac gctcaggctc aggacgccgc
     8881 tgccccggct gctcgtcctc ggcaccgcgg gcacggcgct cacgaccctc cccctgctgc
     8941 tcgtcgggga ccttgtcacc ctgtccgccg ccgtcttcct cccgggactc ttcttcgcgc
     9001 ccaccatgat cgtggtgatg gggctggtgg agaggacggt gccgccggcc gtactcaccg
     9061 agggcatgac ctgggccatc accggcctca gcgtgggtgt ggcgtccggt gccgcggtct
     9121 cgggcgcgat cgtcgaccgc ttcggccccg acggcggctt cgtcgtcgcc gtggccgcgg
     9181 gcgcgaccgc tctgctgacg gccctctgcg cccggcgtcc gctggagcgg agtctccggg
     9241 agcgggcgga ccgagacgcc gagcgaccgg ccgaggcgtc ggccgaggcc cccggaagcg
     9301 ccgcacactg acggacggcg ccgaaacaca tccaccgccc catccaccac gacgcccgga
     9361 ggcaccgtgc acacaccgca gaccgacgga cgcctgctca agggcgagcg acggaaggag
     9421 gaactcatcg aggccacgct ccaggtggtg gcccgggaag gagtcgccgg cgtcagccac
     9481 cgggcggtcg cccgcgaggc cggcctgccc gccaccgccg ccgcctacca cttcacgagc
     9541 atcgacgacc tgctcaccgc cgcgctcacc cgctgcatgg aacaggacgc gcgacgcatg
     9601 ctccggctgg ccgaggaggc cgacggcggc cccgagggcg tcaccgcgct ggcggagctg
     9661 atggagaagg tcgtcaaggg tcccggacgg ctgctcgcgg agtacgagct gtacctgctc
     9721 gcggcccgcc gcccggagct gcgcgccccc acccggcact ggctggaggc catcgccgcg
     9781 tacggccacc gctacaccga cgacccggtc cgggtgcggg tgctcaaggg cgtcatcgac
     9841 ggcctgctgc tccaggggct gctgaccgac accccgccga cggcggcgga gttcgaggcg
     9901 gtactccggc acgtgctgct ctgagccctg cccggccggt ccgcccccgg tcgcggcccg
     9961 ccgtgcgttc ctccggacga cgggccgcga ccattgcgaa ctacgccggg ctgcctgcca
    10021 gttgggtcag caaccgggtg atctgcgccg ccgacgtgcc gagccccgtg ggaccgctga
    10081 tgtgccaggg cgtgccatgg ccgcgccgca ggtcctcctc gcggtagcgc cggcaccccc
    10141 ggtgccagat cagaatcccc gcgatccagt gctcgagctc ccgcacatag cccgccagga
    10201 tctcccgcgc ctcggcgtcc agcgcgaagt cgtcgtacag caccgggagt tcgacctcgg
    10261 cgacatgcag gaactgccgc agccgcgcgt tcatcaggtc gtgcacgatc gccacgcccg
    10321 tcggatagtc gacgccgaag aagttctgca cgaccaggac gccgttgtgg acctcgccct
    10381 cgtactcgat ctccttctgg tacgagaaca ggtcgttcat cagacacgcg tagtccgccg
    10441 ccgcgttctc cagggaacgc atcggaccgc tgcggtagac ctcgtccggg accttcctgc
    10501 cgtgcccgag ccggcacagg ctcatcgtca ggtccgaacc gaacgtcgcc cgccgcatct
    10561 ccacgtagtc caccgggtcg gggatacggt tctgcgcctg gtttgccagc tcccacagcc
    10621 agctctcggt catggactcg atcgaggccc ggaaggtacg ccggccgtcc gcgtccatcg
    10681 gcccggccgt cctgcgccac aggtcgtcca ggccccgctc cagggcgttc accggctccg
    10741 gcgtgccctc gccgtccagc ggcatgaaca gcgagagccg ctcgttggcc agccgcgccc
    10801 ccgccaggtc ccgggtccgc ccgtgcacga ccgggaacca gtcgtccccg tacgtccccc
    10861 aggccagcca ccccgaggac aggtccagct cgtccggggt cgcgtccgga tggatgcccg
    10921 ccgcacagag cggcaggtcg atcgcgacga tccgccgctc gtcccagatg ctcgaacccg
    10981 gcacgcccgg ctgcgcctcc aggatgccca tccgccgcgc ccagtcgacg atccggaccc
    11041 gcgccccctc caggtgcggg ctcagtgtcg tcccgaacgg caggtcgaaa ctcggcagca
    11101 gcgaggggcc cacgcgctgg tacgggacat ggctctggcc gcggacccgc gaggtctccg
    11161 agcggagcgt gaacctgatg gaggcggcgg acatgccgaa cccggccacg gcctcgcccg
    11221 cgccgccgcc gttcatgtag cgactggagc gcatgtgcca ttcgtggccg ccggactgcc
    11281 agtcctggag ccccttgacg tacgccagca cagcggcggt ctgcgtcggg tccaggctct
    11341 tctcggcgca gagcgggccg agttcggtca gcgcggtgtt ctcgaactgc tggagccgtg
    11401 aggtcagcag gtcgttgacc gcctcggcgg cctcctgcgt ggagcagccg aggaacttct
    11461 ccagcaccag cacgccgttg ctgttctccc cctcctcctc cacctcacgc tggtaggaga
    11521 agaggtcgtt gcgcagatgc accgcgtcgg agaacgcgtc ccgcaggacc cgcagcgggc
    11581 gggcgtcggc gaccggagcg ggcacctcgg cgttggccgc gtactccacc agacccgcgg
    11641 accagggcgc gccgcccacc ttgcggcgca tctcgatgta ctcgacgggg ttggcgatgc
    11701 ggccctcgtg gatgttggcg agctcccaca gggactcgtt gaggaggttc tccgtcgcct
    11761 ccgcgaaccg ggcccgccag gcgtccgaca tcgaggggat cgtgcgcgcc cacagatcgg
    11821 cgagccccgc ctcgaccggg ttctccggtt ccggcgtcgg ggcgccgcgt tccatcggca
    11881 tgaaggcagg caggcggtcc agataccgct tgccgccctc ccggtcgggc gtgcgcttga
    11941 acagctccag gaagtggtcg tcgaagaaga agacccacac gtaccagtcg gtgaccaggg
    12001 acagggcctc ggccgagcag tcggggtggg tgtaggcaca cagaagggcg tagtcgtgcg
    12061 cctccaggtc cttctcctcc cagatgccgg atccctccag catccccatg gagcgggccc
    12121 acgcgcgggt gtgcgtgcgt gccgcctcca catgagggtt gagccgcgcc ggatacggaa
    12181 catagaagtc cggcagtgag aagggctgtg ccatgtgcgt cgggcctttc cagaagcctc
    12241 cgcgcgggga aacgcgcgga ccggtggtgt ccgcgcagca ctacccttcg gccatacgga
    12301 gcacgcacgg ccacgattag tcacatgatc gtggcgttgg tgcgtgctca agggccgtcg
    12361 ttcggatgac ggtcgctcgg caaccggtcg ctcagcggtc ggccgctcgg gagtcggtcg
    12421 ctcagtaggc ggagtcgacg ttgtcgatcg agccgtaccg gtccgcggcg tagttggcgg
    12481 cggcggtgat gttggcgacc gggtcggtga gcttcttcgg ggtgcccttg acgtggtagg
    12541 cgtcgaaggt gggctggatc acctggagga gacccttgga gggaatgccg ttctgcgcgt
    12601 tgatgtccca gtcgttgacc gcgttcgggt tgccgctgga ctcgcgcatg atgttgcggt
    12661 gcagcccctc gtaggagccg gggatgttct tcttcttcat gatgtcgagc gactcgcgga
    12721 tccagccgtc gaggttgttc gcgaacttct tgggcgtgac ggccttgcgc tcggtggagc
    12781 ggttggcggc ctgcttctcg gcgcgcgcct ccgcggcgtc cttctccgcg gtggccttgc
    12841 gggcggccac ggccttcttc gcggcggctt ccttggcggc ggtctcctga gcggccttct
    12901 tggccgcggc gtccttcgcc gtggggatgc ccgcggcggc gaccggctcc acggagatgg
    12961 aggaccgggt cgccgtggtc tgcgcttcgc tcgtgccgcc ggtggcggct atggcgctga
    13021 cggaaccggc cgcgacgagc acggcggtgg cgatcttgtg cgagcgggtg atgcgcaggg
    13081 tggagatgcg gggcatgcgt gagctcttcc tatgggggac gggcttcgcg gccttcgcgc
    13141 cgcgtcggcg ggaaccggga tgtccgggcc gcggtcgccg gagggcgatc ggcgcggact
    13201 cgaacgcggt gcctgccggg atccatggtt agcgctcgcc gacataggaa gcaatgaccg
    13261 cctttactac tcttcatcgt gagatgccaa tttatgagcc atatgggcgg ttcgttacgc
    13321 cgtacgggag ggtccgtgcc tactaccgca ggtcgtaggt gacgtgggtc tcgtggcggg
    13381 cctcacccgc gggcggcccc ggggcggcac agggtcaacg cccggtcacg gggtgacgcg
    13441 gcccggaacg cacaacagcg cgctgcggga ccggtgtgtc ggcaccggtc ccgcagcgcg
    13501 cttcttcttc acagtggtct gttcactgtg gttctcggtt ggcggggcct gtccccgctc
    13561 ggtcgtccgg tctcagcggg tgccgaccgc ggcccgcacc gcccgtcgcg ccatggcgca
    13621 gtcgtcgtgc agcctccgca gcagcagccg ctgctcctcg cccgaggaga gggcgccggg
    13681 ccggtcggcc cccgcccccg ccgcgggcgc ctcgcgcatc gtgcgctgga ccgccgtctc
    13741 gtaattgcgg atctcacggg tcagcaccag catcaggttc accaggaacg cgtcccgtgc
    13801 ggccggcccc ctcgcctggg cgagctggct gatctggcgt cgcgccgccg gggcgtcgcc
    13861 cagcaccgcc cacagcgtcg ccaggtcgta ccccgggaga taccacccgg cgtgctccca
    13921 gtcgacgagc accggtccgg tcggcgacaa caggatgttg gagagcaggg cgtccccgtg
    13981 acagaactgc cccatgccct gcctgccgcc cgcgtgggcc agaccgtgca gcagcttctg
    14041 caggtcaccg aggtcacggt cggtgaacag accgagctcg tggtagcgcg cgatccgcga
    14101 cgcgtagtcg agcggcgcct cgaacagtcc gggcggcggc cgccaggcgt tcacccgggc
    14161 gatggccccg agcgcggccc ggatatcggc ccgcggcggc gcctccgccg ggtgccgggt
    14221 gagggcggcg acccggccgg gcatccgctc gatcaccagc gtgcagttct ccggatccgc
    14281 cgcgatcagc cggggcgccc gaacaggggg gcggtgccgg acgaacgcgc ggtacgccgc
    14341 tatttcgtgc cggaaccgtt cggtccacgc cggcgagtgg tccagtaaac acttcgcgac
    14401 ggcggtggcc cgcccggtcg ttccgacgat caggaccgaa cggccgctgc ggcgcagaac
    14461 ctggaccggg ttgaactcgg ggcagatgcg ctgcacggag gcgatggcca tccgcacctg
    14521 cgcgccctgg ggcccggaca ggtcgatcct tccgctgagc ggtccggtgc ccggtcccgc
    14581 ggcccgtcgg gcccggcccg gaccctgcac cggtgcgccg gcgtgaggag cgagataggg
    14641 cccgccgccc gcgcccatcg ggcggagcgg acggggcggg gcggacacgg aggacgatgc
    14701 tgtgtacatg ggcgagacag atcccttcgt gcgccgacaa ggtacgtgcg ccaacccggc
    14761 cgacggccgt tcggcaccct ggggagtacc tagggctgcc gggcggggtg gcgctttcct
    14821 acctgacacc ggagcgcggg tggcagacca tctggcggac cctggcgaac cctggcgaat
    14881 agtcacagcg catctgacag ggggttagtg tcaagtcagc cgagaacctg ggggcttgaa
    14941 gtgaccggag aacccaacac ccgcctttct gacctgttcg gcctggccgg ctggtccaag
    15001 ggcgaactcg cgagattggt gaaccggcag gcggcggcca tgggccaccc gcagctggcc
    15061 accgacacct cgcgcgtcag gcgctggatc gacatggggg agtccccccg tgatcccgtg
    15121 cccgaagtgc tggcggctct gttcaccgag cggctcggcc gtgtcgtgac catcgaggac
    15181 ctcgggttcg gccgacgcgg gcgtgtgggg aagcggcgtg actccgggac ggaacaccat
    15241 cccgatcaac tgccgtgggc gcccgaacgg acggcagcgg tcctcaccga attcacggga
    15301 atggacctca tgctcaaccg acgcggcttg gtgggtgcgg gcgccgcgct cgccgccggc
    15361 tcaaccatcg ccggccccat gtacgactgg ctgcacagcg accccgctcc gatggccgac
    15421 gctccacgtg ccggcgatgc cctgcacgcc gatccagccg gtctcgaccg gtacgaggcg
    15481 gcaccggtcg gctccgagga gatcgaggcc ctggagcatt cggtcgaggt gttccgcgcc
    15541 tgggacgcgt cccggggcgg cggactccag cgcaaggcgg tcgtgggcca gctcaacgag
    15601 gtgggcggca tgctcgccta ccgccacccc gaccatctcc agcgccgctt gtggggcgtc
    15661 gccgccaacc tcgctgtcct ggcgggctgg atgtcccacg acgtcggcct cgaacccacc
    15721 gcccagaagt acttcgtcat cgccgcccac gcggcccgcg agggcggcga ccggccgcgc
    15781 gccggagagg cgctctcccg ggcggcacgc cagatggtgc acctgggacg ccccgacgac
    15841 gcactcgacc tgatgaagct cgccaagtcc ggctccggcg acgagaccct gccgcgtacg
    15901 caggcgatgc tgcgcaccat cgaggcctgg gcacaggcgt cgatgggccg tggccaggcc
    15961 atgcggcgca ccctcggcga ggccgaggag ctcttcgtct cggacaagag cgatgtgccg
    16021 ccgcccagtt ggatgcagat gttcgacgag gccgatatgc acggcatgca ggcgctggcc
    16081 ttccggaccc tggccgagca cgaccagggc gccgcgatca ttgcccagcg ccatgccaag
    16141 caggcgctgg agctgcgggt caacgggcgc cagcggtcga agatcttcga ctacatctcg
    16201 ctggcctcgg cctgcttcat cgccaacgac cccgatcagg ccgaccggta cgcccggctc
    16261 gcgctggtgt cgatggggga gacctcctcg caccgcacct gggaccgcct ccgtgaaatg
    16321 taccggctca ccgggcagtt cgccgggtac ccggggattc aggacctgcg cgaggagatc
    16381 gagctctcga tgccgccgag ccagaagaag gccaagggca cgccggcctg atacggcagc
    16441 gccgctcgcg ctccgtcacg ccctgatacg tccgcgcttc ctcatgcccc gatgcgggcg
    16501 accagcacgc acgcgtcgtc caggcgctcg gccccgccga actcctcgac gacgctccgt
    16561 acgcactcct gtgccgtacg ggcgtccgcg aaccgggggg cgagggcgaa cagcgcctcc
    16621 gggcccgcac cccggtcgcc gcgtcgagtc aggccgtcgg tgtgcagaac gagcacgtca
    16681 ccggggtaca gccgtacctc gtcctgctcg aagaccacgt tggacgcggc gccgagcagc
    16741 atcccgtccg gcgggggcag cagccgcccc gaaccgtggc ggaagagcag cggcgcgggg
    16801 tgtccggcct gcgcccagga caggatggag gtgtcggggt cgaagcggca gcacagagcg
    16861 ctgcccagcg cgggctgtac cgacgtttcg agcacctggt tgaggtgtcc catcagcgcg
    16921 cccggctcga tgccggcgac ggccatgccg cgcagtgcgc ccagcatcat cgccattgcc
    16981 gaggtggcgg gaatgccgtg cccggtgagg tcgccgacgg tgagcagggt gcgtccgtcc
    17041 ggcagttcca tcgcgtcgta ccagtcgccg ccgatgaggc cgctcgactc ggaagggagg
    17101 tagtgcgcgg cgacgtccag ggccccgggg ccctgggacg ggagccgcag cgatccgcgc
    17161 cacgggggta ggacggcttc ctggagctcc acggccatgc ggtgctcggt gcgttcgatg
    17221 tgctcctcgc gccgtaccga cgcgcggtct ctgctcacgg cccgctcgct gcggcgcagc
    17281 tcgctgacgt cccgcaggac tgcccacatg gaggcggtgc agccctcggc gtcgaggacc
    17341 ggctcgcccg tcatgtgcac ggtgcgggtg cggccgtcgg gacgcacgat gcggaactcg
    17401 ccgtccatcg gccggccgtc gacgaggcag cccgtcacca tggcggtcag caccggctgg
    17461 tcctcgggca gcagtacgga cggcaggtcg tcgagggaga ggggggtgga accgggcggc
    17521 ctgccgaaga tctcgtacag ctcctcggac cagctggact cgtcggtgag gaggttccac
    17581 tcggcgctgc ccacccggtt cagcagggaa ccggccctcg ggtcgtccgg ggccccgacg
    17641 gcacgggggg cgtcgtcggc gctccggtcc ggcagacccg cccggagctg gcccaggtgc
    17701 tggtcgaggc tgtccaggtg ctgtaccgcc agctcgcaca gggcgcgctg ccaccgcagc
    17761 tgggggtcgt cctcgtcgag cacgacggtg tcccgccgca cggcgtccac gtccccgcgc
    17821 agccgacgcg tccggtggat cagggcgtcg acggcgtcat gcgcgggaag ctgtggtgcg
    17881 gggcggtccg cgaagtgggg ggacggcatc tcgtactccg atacaggcgc ggcctagccg
    17941 gttctgaagg gtggaccgct accgactgtc gcacaggcca cggcgggtcg taagggattt
    18001 ggcaacactc gacgcgttct tgcgtctggc atatgccagc ggctctccgg ggcggtgagt
    18061 atccgaacag gcttgcgttt ggggcgagtt gaccctgcgg ttcggggtgc gccgcagggc
    18121 gggaatgtcg agggggcggc tcgcgttacc ccaccagaac gaaaacgaat cccattcccg
    18181 atacgggagc ggggtcgtca gaggcatcgg gaggcgccca tggcacgcag tgagaccagg
    18241 ccggtcgtca ccctccggtc caccgtcgga acgggccgga gttatgtgac ccgcaagaac
    18301 cgccgcaaca accccgaccg gctggagctc cgcaagttcg actccgccgc cggtcggcac
    18361 gtcctgttcc gcgaggtccg ctgaccgctc ggaagaggcc tgtctccttg tgtgtcaccg
    18421 ctgcccgcgg tgaggaagga acgcatcgat gaagtcccga atccaccccg tgtcccgtcc
    18481 cgtggtcttc cgtgaccgcg cggccgacgt cgccttcctg acccgctcga ccgccgactc
    18541 cggcgagcgc gtgacgtggc aggacggcaa cagctacccc gtcatcgacg tggacacctc
    18601 gtcggcgagc cacccgttct acaccggcgg cagtcaggtg ctggacacgg cgggccgcgt
    18661 cgaacggttc cggcgtcgtt acggcaccgg cgagacgtcc gggagctgac cgaaccagtc
    18721 ctgaccaggg agggagtccg ggattccgtg ctgtggatca catccgcgga gtccccggaa
    18781 caacccagga tggtttatcg ttcatctata cgtgggagtg agggggaccg tgtccccggg
    18841 cctcacctgc ggcccacggg gaagatcgca ccgccgaagc cccgtggagc cctccgccga
    18901 gaggcgaccg cccttcacgc ccgcacccgg accgccccgg ctggattccc ccgatccggc
    18961 cggggcttct ccttgcccgg ccgcctcggc ccgcaccgac cacacggaac gcgcggatca
    19021 cacggtctcg tcgaggtcct tcgcatagtg ctccatggcc cgacggtact gctggacgtg
    19081 cgggtcctgg ctggtcgcgg cggtcagctc cagcaacagg cgcatcgcct cgtggtgctc
    19141 gtcggtgttg tacagcgcca tcgccaggaa cgcccggagc gaaccgtcgt ccgggaactc
    19201 ctcgacgccc cggcgcagcg tctccaccgc ctgcccgtac cgcccgagga cccggtacgt
    19261 actgcccagc cccaggagcg ctccccggcg gtcctccgaa gcgagttccg gatgcgccag
    19321 agcgcgctcg tagtacggca ccgcctccga ctccaggccc agcacgtcat ggatccaggc
    19381 cgtccggtag gccacttccg cgtcgtcggg gtaccgggcg gtcagggcga ggagctgttc
    19441 gcgcgcctcc tcgggccggc cctccgaacg caaccggtcg gcctcgtcca gcaggtccct
    19501 cttcttgtgt gcgctcatgc gcacatcgtc gcaggtgggc gcggacgaca gcatgagatt
    19561 ttcgctccgc gggaccgtcc aggcgtgtgt tccggccggt cgggggcacc cgtcggccat
    19621 gacagcagag gcgaatcccc gtacagaccg ggggacatgg gtacgtgtac tggtgcgcgg
    19681 agcggtcctg acggtggtgc tcctgggact cgtggcgttc tccgtcctcc tggccaaggt
    19741 gacgctcacg ccgtcaccgg catccgcgga cctcgtcacc gcgaatctcc gccccggccg
    19801 ctcgctgcgc cagtacgccg aggactacac cttcctcgcc gcgtgcaagc aggcgggcgg
    19861 gaacctgctg ctcggcgtgc cgttcggact cctgctgccg ttcttcgtgc cacgccgcct
    19921 gcgcatgatc cggacgacgc tgctgaccgc cgtcgccatg gccgtcgtcg aactgatcca
    19981 gggggccctg gtcgaggggc gcgccttcga catcgacgac gtcatcctca acacggcggg
    20041 cgcgctgctg gggtacttcg tgctgggtcg ccggatcagc caccgctact acacctacac
    20101 cgacgactcg gtctcccccg gcccgtcggc ggagaagccc ggggctgagc tgaagcgcgc
    20161 gcccgggccg tccgcccgta cgaagaccgc ccgtaccggg gccggcgccg tccactccct
    20221 gctcgaccgc ctccgcgggc gctgagcagg ggcacccgtt cgggccgggc cgtttgcggg
    20281 cggcccggag cggacgcacg gtggggacac gtcctgcgcg cggatggcgc cggatcccct
    20341 gccgaggagg agcgacatgg ccgagggcca gtggagcccg ggccgcaagg aggcggacgc
    20401 ggacgagttc aggcccgtcc tggacatcgt cgaaccggcc cgtcagcgcc ggctgaccgt
    20461 cctcctgcga ctcctgctgc tgatcccgca cttcgtcgtg ctgttcgtcc tgcacatcgc
    20521 ggcgttcttc accgtcatcg tgggttggtt cgcggcgctg gtgctgggac ggctgcccga
    20581 ctccgtcttc cgcttcctga ccggcgtcct cggctacgac atgcgcgtct cggcgagcga
    20641 catgctgctc atcgaccgct acccgccctt cgccctgacc ccgccggccg actatccggt
    20701 gcggatcgag gtgcggccca ccccgctcaa ccggctcgcg gtgctgttcc gcttcttcct
    20761 gatgatcccg gcggcgatcg tgcagagtct cgccgtgtac gggtggtggg cgctggcctt
    20821 cgtctggtgg ctgatcacgc tgtgtctcgg ccggatgccc cggccgctgt tcgaggcgac
    20881 ggcggccacc ctgcgctacc ggatgcggtt ctccgcgtac gtcatgatgc tcacccccgc
    20941 ctaccccaag ggcctgttcg gcgacgacga cctcgccgtg gccccggagc gggcgcgctc
    21001 cgccacccgc ccactggtcc tgagcagcgc cgcgaaatgg ctcgtggtgc tgttcctggt
    21061 gctgggcctg gcgggtcacg tcatctcgtc cgtgaccgcg tccacgaccg acgacatcga
    21121 cgacacctac gacacgcggc tcgtgggtcc ctgaggcccg ccgggccccg cccccgccgc
    21181 ggcggcacag cggcgcgcca gcagggcgaa ggcgtccctg agcgcgtcgg gcccgacgac
    21241 ctcgatgtcc acgtcgaacc tgccgagttc ggcggcgagg ccggcccagg accaggcgcc
    21301 caggaccacg cggcagcggt ccgggccgtg ctcctcgacg ctcccgtcgc ggatgtggcc
    21361 ggccaccgcg gaggccggcg cgtcgaggat cacctccccg cggcagggcc actcgccggg
    21421 ggcgccggag ccctggaacc gggcggcgac gaaggcggcg acatcgcccc cgggcacctc
    21481 gcgcggcgcg aaacgggggc cggtgggagt gcgcggggtg atccggtccg cgcggaaggt
    21541 ccgccagtcc tcgcgatcca ggtcccaggc gacgagatac cagcgcccgc cccaggtgac
    21601 caggcggtgc ggctccaccc gccgcaccgc gggcggggcc tcggcggagg gcgcagcgta
    21661 cgcgggggag tggtcgaagc gcagcacctc gcgggcgtgc accgccgcgc tcaacgtcac
    21721 gagcacccgc ggatcggcct gcggccgcgg cgggcctccc gtacgttcga cggcggtgac
    21781 ccgcagggcg tccacgcgat ggcgcagccg ggccggcatg acctgccgga cggtggtcag
    21841 cgcgcgggcc gcggcctccc cgatcccggc gccggtcgcg gcggcggtcc gcagcgcgac
    21901 ggcgagcgcg acggcctggt cgtcgtcgaa gagcaacggc ggcaactgcg cgcccgcgtc
    21961 cagccggtat ccgccgtcgg gccccttgaa cgccgcgatc ggatagccca gctcccgcag
    22021 ccggtcgaca tcgcgccgca ccgtgcgcgg gctgacctcc aaccgctcgg ccagcaaccg
    22081 ccccggccag tcccggcgcg cctggagcag ggagagcagc gccagcaggc gcgctgaagt
    22141 cttcggcatg acaccagtat gagtcgagta gaggccacac cctggcctct acccctgcga
    22201 gggtctaccc gtac
//
