LOCUS       NZ_KZ195572            28886 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS057 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195572
VERSION     NZ_KZ195572.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS057
  ORGANISM  Streptomyces sp. CS057
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 265.32x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188345.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:40:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,152
            CDSs (total)                      :: 7,074
            Genes (coding)                    :: 6,991
            CDSs (with protein)               :: 6,991
            Genes (RNA)                       :: 78
            rRNAs                             :: 10, 6 (16S, 23S)
            complete rRNAs                    :: 10, 6 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 23 of 83
            Pseudo Genes (incomplete)         :: 71 of 83
            Pseudo Genes (internal stop)      :: 4 of 83
            Pseudo Genes (multiple problems)  :: 14 of 83
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:25:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2989076
            Orig. end                         :: 3017962
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..28886
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="22"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..28886
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28886
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18886](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..18886)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(39..1262)
                     /locus_tag="B9W61_RS12335"
                     /old_locus_tag="B9W61_12315"
     CDS             complement(39..1262)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906225.1"
                     /locus_tag="B9W61_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12315"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_179233752.1"
                     /transl_table=11
                     /translation="MSSSTPAPDIAVIGAGIGGLTLAAALARLGIGCRVFERAEQPAET
                     GAGVQLAPNAVRLLRRLGLSDSLRQYGVRPLSRDLLRWDDGRLLGRTGLGEECEKLFGA
                     PYVTVHRADLHRALRDLVGPVVRTGHRLTGLAEEPGAVVLRFADGSEHRSELVVGADGI
                     RSVVREHLAADAPVFSGRRIYRGLVPVERVPELADEPRVQVWLGPGRHCVCYPVSGGRL
                     ISFAATTGGTALPGESWTALGDRGEAAEAFQGWHPTVTRLLGAGGGIGCWALHDREPLA
                     RWSSDALTLLGDAAHPMLPFAAQGANQAIEDAFALAATLAQSRGDFPAALRRYEELRIP
                     RTERLQRSARSVAVGSHLPDGPLQRARDAELASGSGLEGLRWVYGHDALAAAVRAPRTV
                     PAGAEEGG"
     gene            complement(1252..2361)
                     /locus_tag="B9W61_RS12340"
                     /old_locus_tag="B9W61_12320"
     CDS             complement(1252..2361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547674.1"
                     /locus_tag="B9W61_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12320"
                     /product="3-dehydroquinate synthase II family protein"
                     /protein_id="WP_087765118.1"
                     /transl_table=11
                     /translation="MSSEKLCWLDIRSAGKARQAIVEEALHQRVDGIVAADPADLEGLP
                     PTVTKVLMPPPGKQPASYGSAGVVILAGDASARARAAEAAPDVEFGRLVEITDAESLDA
                     AIEAARTERWSVLDFRDPTKIPLEIVIAAAADADGAIITMAKNTEEAAVIFGCLQLGSD
                     GVLMPGRSVGDATALKATAAGGTGELLLVELEVTAVSHIGMGERACVDTCSYLGKDEGI
                     LVGSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLADEGRTRYLSELRAGSKVMA
                     VDTKGRTRTVAVGRVKIETRPLISIDAVAAGGQEVNLILQDDWHVRVLGPGDAVLNSTE
                     LRPGDRVLGHLPTADRHVGYPIDEFCHEQ"
     gene            complement(2333..3175)
                     /locus_tag="B9W61_RS12345"
                     /old_locus_tag="B9W61_12325"
     CDS             complement(2333..3175)
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455580.1"
                     /locus_tag="B9W61_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12325"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_047178576.1"
                     /transl_table=11
                     /translation="MTTHQHFGRAVRLRRLFHHDPRRLMIVPLDHSLSDGPVVPRGSSI
                     DRLAGQLSGAGVDAIVVHKGSVRHIDHSRLAAMSLILHLNASTAHAPDPDAKHLVTGVE
                     AALRLGADAVSVHINMGSREEARQLADLGAVADQCDRWNLPLLAMMYPRGPKITDPADP
                     ELVAHAVTLAADLGADLVKAPCLRTRAEMRDLTAACPIPLICAGGPQRDTEDEVLAFAR
                     EAVAGGAAGVAMGRNIFQSPDPGAMAARVAGVVHHRPGGTLGHIEEGHGSELRETVLA"
     gene            complement(3172..4818)
                     /locus_tag="B9W61_RS12350"
                     /old_locus_tag="B9W61_12330"
     CDS             complement(3172..4818)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (23-440). E-value: 3.9e-69.
                     Score: 225.1. Matches aSDomain:
                     nrpspksdomains_B9W61_RS12350_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906215.1"
                     /locus_tag="B9W61_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12330"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_179233753.1"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-71, bitscore:
                     238.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPIDVPDSWAGHEHYARRVLWRLARQPSLPTLYFQGRWLDGAT
                     LADAVRATAVGLRRAGLTPGGTVAVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSD
                     AFPLPAATQARILDETGTSVILVDAPHLERARALVSLTGGGPRLLGYGVGAAECPDTLS
                     YRDEPLGEIPAHSPDRRALVAFTSGSSGTPKSIHQTFGVWDSTVRSAASGEPDERRVFL
                     AVTPLSHTIGAMADAVLAAGGQVLLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTEL
                     LADAPGHEQPPGSGPVGEALWSLRRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAG
                     GISNLSPFDHLEPELLGSVGRPLPWVEVEVREPGTGDPVPRGESGEIWVRASTVMDGYP
                     NDPEQTARVLRDGWLDTGDLGRWDRYGYLRLTGRSGQVIKSGGLKIYPAAVERALLSHP
                     AVRNAAVHGVRDPDRTEYVHAAVVFRAGRTSTAEELRTHVGEQLSPLHAPAEITFWDSM
                     PLNERGKPDLACLRSGNGRQAYDGAPPKGTP"
     aSDomain        complement(3499..4749)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS12350_AMP-binding.1"
                     /evalue="3.90E-69"
                     /label="B9W61_RS12350_AMP-binding.1"
                     /locus_tag="B9W61_RS12350"
                     /protein_end="440"
                     /protein_start="23"
                     /score="225.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RLARQPSLPTLYFQGRWLDGATLADAVRATAVGLRRAGLTPGGTV
                     AVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSDAFPLPAATQARILDETGTSVILV
                     DAPHLERARALVSLTGGGPRLLGYGVGAAECPDTLSYRDEPLGEIPAHSPDRRALVAFT
                     SGSSGTPKSIHQTFGVWDSTVRSAASGEPDERRVFLAVTPLSHTIGAMADAVLAAGGQV
                     LLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTELLADAPGHEQPPGSGPVGEALWSL
                     RRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAGGISNLSPFDHLEPELLGSVGRPL
                     PWVEVEVREPGTGDPVPRGESGEIWVRASTVMDGYPNDPEQTARVLRDGWLDTGDLGRW
                     DRYGYLRLTGRSGQVIKS"
     CDS_motif       complement(3598..3681)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W61_RS12350_0002"
                     /evalue="4.00E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="B9W61_RS12350"
                     /protein_end="407"
                     /protein_start="379"
                     /score="22.4"
                     /tool="antismash"
                     /translation="PRGESGEIWVRASTVMDGYPNDPEQTAR"
     CDS_motif       complement(4231..4278)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9W61_RS12350_0001"
                     /evalue="2.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="B9W61_RS12350"
                     /protein_end="196"
                     /protein_start="180"
                     /score="13.8"
                     /tool="antismash"
                     /translation="ALVAFTSGSSGTPKSI"
     misc_feature    4818..4831
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            complement(4934..5104)
                     /locus_tag="B9W61_RS12355"
                     /old_locus_tag="B9W61_12335"
     CDS             complement(4934..5104)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="B9W61_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12335"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_087765120.1"
                     /transl_table=11
                     /translation="MRSTLETADVDAMFDSFDIEELDTMEIADGVALPEMAASSIPVTC
                     CSSSSSSCCCC"
     misc_feature    complement(5152..5168)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            complement(5315..5479)
                     /locus_tag="B9W61_RS35835"
     CDS             complement(5315..5479)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="B9W61_RS35835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin"
                     /protein_id="WP_179233754.1"
                     /transl_table=11
                     /translation="MSKTMETMDVDAMFASFDIEELDTLEIADGVALPEMGASYLNAPL
                     CCSSSSSCC"
     misc_feature    complement(5525..5541)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     misc_feature    complement(5579..5594)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.78"
                     /tool="antismash"
     misc_feature    complement(5749..5764)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     gene            complement(5868..6032)
                     /locus_tag="B9W61_RS35840"
     CDS             complement(5868..6032)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="B9W61_RS35840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_239110092.1"
                     /transl_table=11
                     /translation="MSKIVETMDVDAMFDSFDIEELGTMELADGVALPEMGASKGDFTC
                     CSSSSSSCC"
     misc_feature    6129..6142
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.12"
                     /tool="antismash"
     misc_feature    complement(6129..6144)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    complement(6132..6145)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.75"
                     /tool="antismash"
     gene            complement(6239..6403)
                     /locus_tag="B9W61_RS12360"
                     /old_locus_tag="B9W61_12340"
     CDS             complement(6239..6403)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="B9W61_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12340"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740161.1"
                     /transl_table=11
                     /translation="MSMAIEAMNADALFDSFDIEELDTMEVADGVALPEMGASTGNTMC
                     CSSSSSSCC"
     misc_feature    complement(6423..6438)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.71"
                     /tool="antismash"
     misc_feature    6457..6471
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(6504..6519)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     gene            6644..8278
                     /locus_tag="B9W61_RS12365"
                     /old_locus_tag="B9W61_12345"
     CDS             6644..8278
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058915.1"
                     /locus_tag="B9W61_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12345"
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_087765121.1"
                     /transl_table=11
                     /translation="MNGISGSRGRGAGAPEADVLVVGYGPVGQVLSILLARSGWRVVVV
                     ERHPEPYSLPRAVAFDAEAARTLDAIGVTGRIVDITEPSQDYVVSDAAGRQLLRIGLGG
                     TDGTGRPDSTSVYQPGLEAALAARGEELPTLRVHRGLRAVELTESGSGAELVAEDERGG
                     ERRTFTASWVVGCDGAGSFVRRSLGIGWADSGFALDWLACDVVPDRPEDFPPSNLQIAD
                     PARPRVAVSCGPGRRRWEFMRMPGEDRAEFGTEENAWRLLSMFSARPDNATLTRHATYT
                     FRARNAEHWRRGRVLLAGDAAHQMPPFAGQGMCSGFRDAANLAWKLDLVLGGRAGEALL
                     DSYEQERRAHVQHAIDLSVRLGRLICVTDPAAAADRDRAMTARSPGQDRPAEPVRPAGP
                     ARSARPLGEHLAKGFLADGGPPAGELTARARLTGPDGPGPADSVLGPGFVLLCRGNLAD
                     TLSPAALETLRPVSGRVVTVLRSDAGSAPGPDTVLDTDGHWLPWLESLQAGAVLIRPDH
                     YLFGAAPDADGLAALLTEFGRRLRPAG"
     gene            complement(8310..9050)
                     /locus_tag="B9W61_RS12370"
                     /old_locus_tag="B9W61_12350"
     CDS             complement(8310..9050)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451942.1"
                     /locus_tag="B9W61_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12350"
                     /product="ABC transporter permease"
                     /protein_id="WP_087765122.1"
                     /transl_table=11
                     /translation="MSSLTLVHARYQLVELSRIPMAIIGAAFFPAASLIFFVVPNTKDD
                     PVGATLATASMVVFAAMISNLFGHGTGVAEDRSQPWDPYTRTLPIGPAVRFGSRIITGL
                     AMMLFSMVPVVIVAAFFTPATLSPARFLLAIGVVIVVSVPFTMMGLAIGYLLSTKAAIA
                     TVQLVFLPLAFAGGLLAGPGEAPGFIETIAPFVPTRGSAELMWATVGDYDINPVAIVSL
                     VVWTVGLAALAFYAYQRDEGRRYH"
     gene            complement(9084..10001)
                     /locus_tag="B9W61_RS12375"
                     /old_locus_tag="B9W61_12355"
     CDS             complement(9084..10001)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451944.1"
                     /locus_tag="B9W61_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12355"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087765123.1"
                     /transl_table=11
                     /translation="MSTSPTTATARAGAPPTPTVIARAIGVTRHYGDTVALDNVDFTVR
                     EGEFIGLLGPNGAGKTTLLNSLLGLRKPTSGSIELFGGSPTNPANRRFIGVTPQESGVP
                     PTLRVAEAVDFVAAHFKETEDRDELLERFDLTKEARRQTGGLSGGQKRRLALALAFVGR
                     PRLVILDEPTTGLDVESRRMLWDRIREFHEGGGTVLLTTHYLEEIEALAKRVVVIAQGR
                     IRADDTVGAIRGMAHMQRVSMNAGPLPDLPGVISEERTEERVELMTHDADQLVRALVRQ
                     GVEFSGLAVQQATLEEAFLVISQS"
     gene            complement(10001..11023)
                     /locus_tag="B9W61_RS12380"
                     /old_locus_tag="B9W61_12360"
     CDS             complement(10001..11023)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906224.1"
                     /locus_tag="B9W61_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12360"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_087765124.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-39, bitscore:
                     134.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDASETARAGGGAGPGGPDTVWRTWHLHVPSGDRSAHDRVVVDA
                     VGSVLPTLQGRPWFFLRYWHGGPHVRLRIGDLTDDQAASAERLLAERLAEAGRPREGET
                     AMDPADYARTAAAMTTAGDQPSHQEVTGMLEPGVHRFAYHPEYERYGGRELMPESERLF
                     ELSSRLVLAFLRRGPSSGARALLALRATVCAARALGDDPAEQAAFYDHGLRAWRTWTVG
                     YGYTEQQLDELYRAARPTDELRAKATGGDTTGPLAPWQAALTGLSDRIRRETPLHPAQV
                     TVSHVHMLHNRLGLRAVEEYQTYARLARLFPARSAPEGASPSDHSGPAQSGAVLSTEEH
                     "
     gene            complement(11038..12522)
                     /locus_tag="B9W61_RS12385"
                     /old_locus_tag="B9W61_12365"
     CDS             complement(11038..12522)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553604.1"
                     /locus_tag="B9W61_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12365"
                     /product="hypothetical protein"
                     /protein_id="WP_087765125.1"
                     /sec_met_domain="PF00881 (E-value: 7.4e-05, bitscore: 21.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSDRGGPASPIPDDADVMSRDMRWFTHATGLGVRVDAEVVPE
                     PRPDTEVAPALPEAALGDRTPLPRGTAELLERAAYPHGRAGSPRDRSDALGHALVAGFG
                     LQRREPENPFNDHRPYPSVRAKFPVQVFVRDGRHRRVLDLYRHALTGVGRQDGADGPLE
                     VALAGRYTRLPDSYRWFRSSLIGLELGINLRQLCLGMELFGLSGTLRLPDRDAAGLLTD
                     FGLTPESEWSLPLTVALEDGGPSVAAAPAERAADPVLDGILTVNRAQDFTGPAAPLGPS
                     VPADLPRDGALSWAEVLWRRSAGRMPRGMYGMTGRRRPVPERTLREAVSWLSVPPPGPH
                     LAAAWEELRLTAVFQGIEGHADGVWHLKDGRPVLHRAHPGAAAELETHYGYPVTPYAGG
                     DIRHASAVWFLSAHPRRLVDRLGPGGFTAAQYAAGWAAQGISLAAAATGLYARPARAFQ
                     EVPTRHILGLDPDEMIVCAAITGTPRFEGLLCDLRL"
     gene            complement(12605..14536)
                     /locus_tag="B9W61_RS12390"
                     /old_locus_tag="B9W61_12370"
     CDS             complement(12605..14536)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451953.1"
                     /locus_tag="B9W61_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12370"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_047178570.1"
                     /sec_met_domain="TIGR03604 (E-value: 2.2e-65, bitscore:
                     219.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 8e-66, bitscore: 221.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENPTTVVCAPALSDDAGTEWRAVLEPLGAFGDGTVGANLGWDL
                     DWEREQLRSADGREHLSVRVYGDEVLVGPRWVPGTDSGCAGCAELRSRLVIDHPLTDDL
                     SRPTSRVAPRRPFLPELTRAALARLADRPLGPGELYAVGARGTRTHRVPRHFACPLCAP
                     EIPEHPVGRPPEPLALRPRPAAADNPGRAAAGAGLVRPGALRSRLVDPRFGPVLAQQRE
                     LLAPFAMSMALQPDAVALGYARETTFARADPIAILEVYERLSGFPHQAPLVEGVSYAEL
                     VRTEGGAEVAIRPAEFGEYTEEQAARPTARIERVTDDTPMDWAWGHDLADGRPRLVPAE
                     LAFFQYDYRYGRQQRAARRHGAPPRRHLYQESSSGCAVGSCLEEAALYSLLELAERDAF
                     LISFHRALPLPEITHSSITDPVARGLLATAASRGFRVHLLRATQDIDLPVVWAMAVNTR
                     APFPATFSAAGSGIDPVSALRGALWEVTQMATERLTWDRSDAEPMLADPWSVDEMDDHL
                     RLYALPEMKERVTAVLGGPEMSLSEAFEGWPDRLEQAAGGDVLGALDYVRGRYADAGLD
                     RIVLVDSTTRDHADIGLAAARAVVPGIVPMCFGQAQQRVAGLPRLEAALVGTPSGKLSP
                     PYDPHAFP"
     gene            complement(14529..16346)
                     /locus_tag="B9W61_RS12395"
                     /old_locus_tag="B9W61_12375"
     CDS             complement(14529..16346)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9W61_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B9W61_12375"
                     /product="hypothetical protein"
                     /protein_id="WP_087765126.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.4e-08,
                     bitscore: 33.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADICVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARGLLLDLDALTVPEPSAEIRARYPEAL
                     AHLETECADPYAVFQRLRTTEVLLCGPADAVLPAARGLHRAGVTGLTLATPDPDAAAAT
                     ASRLGMRLLPLGDTATLPDPGDLPVPPDAVLHCPGADDGVTAEALTALLPAGAPLVPVR
                     WDGLVAAVGPVAPGGASLAGSAALVRRAARWAVDEATAPVPHPTAAALAGALAGQLLFD
                     TLAGIAPPGEAHVLHGEELTADRVHLTAPGPAAGEAAERRFLTAAPEAGAEPVPPPTPD
                     EAVEAVTALTGRWTGPLALLGGEELPQMPLALREMAARDGDAGSVVAWAEEQRTATVAV
                     ALAALRAACPTPGTAAAGLTEEHWLLDGALRLMADEAVPYATRAVGAVDARSVPLLRLL
                     EEEGMPAPALTLLRHPGLDWTLAEVRTSGGPRPWTGRSWGRDDTEAVHRALATALARHQ
                     AHGVPGAGPLAEGVHTDALLFADASEQAALRKRVADAAEAAGLRYEGTPRRPDPVTGAL
                     PLWSGAVRAVPLVGEPQGTEESIEERDHG"
     aSDomain        complement(16101..16346)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B9W61_RS12395_Thiopeptide_F_RRE.1"
                     /evalue="5.60E-11"
                     /identifier="RREFam004.1"
                     /label="B9W61_RS12395"
                     /locus_tag="B9W61_RS12395"
                     /protein_end="82"
                     /protein_start="0"
                     /score="33.3"
                     /tool="antismash"
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADICVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARGLLL"
     gene            complement(16343..18886)
                     /locus_tag="B9W61_RS12400"
                     /old_locus_tag="B9W61_12380"
     CDS             complement(16343..18886)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451956.1"
                     /locus_tag="B9W61_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12380"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_087765127.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-10, bitscore:
                     39.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTAEPLWMLRLNPLRRRRLADPGLLAALRTLDGATTEVRELAD
                     RCSDALYEMIGATTDREARGQLIVLRRAIHNDTAPRPALLVDHPLVGRWWEARQRREAH
                     AADVVGHYPRAVDAERGTLAGLLGDESLRHSMTLVAPEAAAGAERYRAAVAATEPVPTR
                     LRKSERGLVQYVTRAMVRTSPMARFTAIGLAVPVPEGPGPDAPEFGRVVPFQGLDRVML
                     DYVLGGLHTADGDLTPDTLLQLPPTADLSAEGDLLYFLQPGADGGVRRLSAKVTGAVGL
                     LVAAVAVGPRRVADVVADFAARSGCTPELARQALARAVGAGILCTRSRPEDGAADFPEL
                     LDPAVPAVPETARRLLERTGAELRGLADNSADERPEALSRLRDTLVTLSREAGRPAQIL
                     IEEDAVLEDVRVSTADWRSQLDDLAAGVALLSVFDWMHDIRALLSTVFVERFGVGAEVS
                     LSDHADYLSAETYRRAYRLPENEPPGELGPADRSLDRLYALRANIVDTAIAAIDQAAAT
                     GEAVNWSASQALDLTTGLPDRFRTGDLRYGVLTQTWRRQLLFNEAYAGHGMLYGRFLGP
                     DRALGGRALPHFREQLRARYAEQGGRLVEDPGLHRLNVNAHPPVLPDRLRPDDWFRLRL
                     RHDPDTDALSILDPDGRPLHMLSLGTGHPERLPAPLRLANWLYSGGVLREPFVAIRHAE
                     RPWDGDRTLACPRFQVGSAMLARRRWYGGRELDEAVAAGPAEHDRLLALARWRNRHGVP
                     EEVVLKPPPGDGSAEGQAAGAGRAAGEGRKKKPQYVDLASALSVRVLPRMVERGEAAYV
                     EEALPRVADSPHALEWIVDIGRAPGGPFQYGGKTR"
     gene            complement(18883..20028)
                     /locus_tag="B9W61_RS12405"
                     /old_locus_tag="B9W61_12385"
     CDS             complement(18883..20028)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451957.1"
                     /locus_tag="B9W61_RS12405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12385"
                     /product="hypothetical protein"
                     /protein_id="WP_179233755.1"
                     /transl_table=11
                     /translation="MITDTAAAGPEMSGTAGVRLYSRVPITPRWLARNVLPVSRRLRED
                     RQAALLHLRRGWLYGPHVDIVARSVPGRPPLDWAGIAAALDAGPADGATVLDEETYLAQ
                     ARETGRLEGVAPPYLPMREHGATEALSFSSVETWPQPLQDLREMALDQLDRPLTTTVEQ
                     LVEKPREAPVRLMEAFIALASAHQYGAGNGAFSMRSHAEAFFAWAAARKDPRPAFAQRL
                     AADAPRLRPVVERALSGTPDHGTAAWARAFAYSMGAFDATVAQGSLTLDDIDGLGAGFD
                     LDTMGPPGGDGRVSHEPSAFHRTMDESGVIASPPKWFASYRLLVNLFYQQLPLLGVPPM
                     HRYYFCFAVAELVDEVLGSSWQDRLEQTRQEMAEATAGAAE"
     misc_feature    20014..20029
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     misc_feature    20024..20037
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    20107..20123
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            20370..21080
                     /locus_tag="B9W61_RS12410"
                     /old_locus_tag="B9W61_12390"
     CDS             20370..21080
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451958.1"
                     /locus_tag="B9W61_RS12410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12390"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_087767809.1"
                     /transl_table=11
                     /translation="MYSTEHAEIYDFIHAARGRDWSAEADGITRLVRERCPAADSLLDV
                     ACGTGAHLERFAGHFGTVAGVELSPEMRRTATRRVPAARVHEGDMREFELGRTFDAVLC
                     MCFSMGYMSTVEELRRSAAALVRHLAPGGVLVAEPWWFPEQFMDGFISASLAQEEGRAV
                     SRLSHSVRDGRVSRMTVRYTVAEATGIREFTEYETYSLFTREEYLEAFRQAGCEMEFLS
                     DWPNGRGLFIGGRP"
     gene            21324..21965
                     /locus_tag="B9W61_RS12415"
                     /old_locus_tag="B9W61_12395"
     CDS             21324..21965
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446992.1"
                     /locus_tag="B9W61_RS12415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12395"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_052658862.1"
                     /transl_table=11
                     /translation="MSEPSDRIAGVGARADSGVEVFERHYAGEPGAGWEIQRPQTVLVR
                     LAEEGALRGRVLDVGCGSGDNALLAAEHGLETTGVDAAPSAITLAVGKARERGLKARFL
                     EWDALDLAALGEQFDTIIDVGLFHCFAPEDRPLVARSMASVVPPGGRCFLMCFSDRQPG
                     DWGPRRVPEQAVRESFTGAGWRVDTLEAAELDVAFSPGVAQAWFAAMTRL"
     gene            21988..23292
                     /locus_tag="B9W61_RS12420"
                     /old_locus_tag="B9W61_12400"
     CDS             21988..23292
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF044385.2"
                     /locus_tag="B9W61_RS12420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12400"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_087765128.1"
                     /sec_met_domain="MGT (E-value: 2.2e-115, bitscore: 384.7,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFCTWPAAAHLYPSVPMARALHDAGHEVRVISHPSLLDTINA
                     TGLTGVSLGDEQTLPQPLGAGRPISPDTYADLVRITKSLELDGYERYVWTYYRDYMLPA
                     VRDFQPEGAPAGEPQSALDALVGFCRSWRPDLVLWDPTMPAAGVAARVSGAAHARILWG
                     PDLFGWAHEQYARCRKLSGDALLPEDPMTSSVRPMAERYGLPMTDELLFGQWTVNPVLE
                     RMRLPTVKRTVSMRWQAYTGPAVLPDWLKEPPARPRVAITLGSSIRAWGRDSALLVNRV
                     LEMVDGLDIEAVATLDASQLAVADRIPDNVRTVDYLPLTELLPTCSAVIHHGGHGSFGA
                     ALVNRIPQFVVMDPGYPMEAPITGRFLSESGVGTGVRVDRHTGAELRAGLSRLLTAPSF
                     RDAAAELYTDLLTAPEPSEIIPVLERLTRHHQSRD"
     gene            23339..24490
                     /locus_tag="B9W61_RS12425"
                     /old_locus_tag="B9W61_12405"
     CDS             23339..24490
                     /NRPS_PKS="Domain: Aminotran_5 (32-160). E-value: 7.9e-12.
                     Score: 36.7. Matches aSDomain:
                     nrpspksdomains_B9W61_RS12425_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446988.1"
                     /locus_tag="B9W61_RS12425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12405"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_087765129.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.8e-89,
                     bitscore: 298.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.8e-07, bitscore:
                     26.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-08, bitscore:
                     33.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVFQPNLGEAELLALSEVFASNWLGHGPRTDEFEARFADHIGV
                     EPDRMVFLNSGTAGLFLATELLDLGPGDEVVLPSVSFVAAANAIAATGARPVFCDVDPR
                     GLHPTVEHIERAMTPRTRAVIVLHYGGYPGEVEGITALCRQRGVPLVEDTACAVASTVD
                     GRACGTFGDIALWSFDAMKVLVTGDGGMLYVRDPQLARRARVLAYHGLEQPSGFAHAKV
                     SERWWELDVRNFGRRVIGNDLTAALGTVQLARLPANVARRREVATAYDTLLANTPGVRL
                     PPPLPEGHRSSYYFYWVQMDPLIRDRVAATLLAQDIYTTFKYPPLHRVPAYGDRATHLP
                     GTDLATDSTLLLPLHQALSDADIRTVANALCEAVTHHLALAGA"
     aSDomain        23435..23818
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS12425_Aminotran_5.1"
                     /evalue="7.90E-12"
                     /label="B9W61_RS12425_Aminotran_5.1"
                     /locus_tag="B9W61_RS12425"
                     /protein_end="160"
                     /protein_start="32"
                     /score="36.7"
                     /tool="antismash"
                     /translation="DEFEARFADHIGVEPDRMVFLNSGTAGLFLATELLDLGPGDEVVL
                     PSVSFVAAANAIAATGARPVFCDVDPRGLHPTVEHIERAMTPRTRAVIVLHYGGYPGEV
                     EGITALCRQRGVPLVEDTACAVAS"
     gene            24513..25580
                     /locus_tag="B9W61_RS12430"
                     /old_locus_tag="B9W61_12410"
     CDS             24513..25580
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952578.1"
                     /locus_tag="B9W61_RS12430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12410"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_087765130.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-13, bitscore:
                     50.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALILAGGLGTRLRPFTETMPKQLIPIANQPVLEHVLENLRALG
                     VREICVVVGAWGPDIAARIGDGSRFGARITYLTQQRPLGLAHCVAIARPFLGDDDFVMY
                     LGDNVVQDGIAEPAKEFRARRSDAHMVVARVADPRAFGVAELDGLGRVRRLVEKPRLPL
                     SDLALIGVYFFRPAIHRAVAAIGPSARGELEITDAVQWLVDRGSQVTAGEYTGYWKDTG
                     RVEDVLDCNRRLLDSLARGVHGTVDAASRLTGPVHIAPGATVLRSVITGPVIVGPGSRV
                     EDCRIGPGTSIGGDCVLRGTELENSIVMDGAWVTERTGASDLLIGRSMRIGSGSPPVPP
                     PAELAANGARTGGTR"
     gene            25577..26569
                     /gene="rfbB"
                     /locus_tag="B9W61_RS12435"
                     /old_locus_tag="B9W61_12415"
     CDS             25577..26569
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-187). E-value: 2.6e-19.
                     Score: 61.2. Matches aSDomain:
                     nrpspksdomains_B9W61_RS12435_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446986.1"
                     /locus_tag="B9W61_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12415"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_087765131.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.1e-24, bitscore:
                     83.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5e-18, bitscore:
                     63.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.1e-17, bitscore:
                     61.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNA
                     ENIPIGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVG
                     TQTLLDACLAARVERVVHISTDEVYGSIDEGSWHEESPLLPNSPYAASKAAADLTVRAY
                     WRTFGLDVSITRCSNTYGPYQHPEKAIPRFTTNLLEGEPIPLYGSGRNVRDWIHVDDHA
                     RAVQLVLTKGVAGGVYHVGGGHELTNIELAEQLIALCGADRSMIRHVTDRKGHDLRYSL
                     DGSKARTELGFTPRVGFAEGLAATVDWYRENTAWWKAAKAQAADTEDRS"
     aSDomain        25589..26137
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS12435_NAD_binding_4.1"
                     /evalue="2.60E-19"
                     /label="B9W61_RS12435_NAD_binding_4.1"
                     /locus_tag="B9W61_RS12435"
                     /protein_end="187"
                     /protein_start="4"
                     /score="61.2"
                     /tool="antismash"
                     /translation="VTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNAENIP
                     IGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVGTQTL
                     LDACLAARVERVVHISTDEVYGSIDEGSWHEESPLLPNSPYAASKAAADLTVRAYWRTF
                     GLDVSITRCSNTYGPYQHPE"
     gene            26566..27873
                     /gene="rfbH"
                     /locus_tag="B9W61_RS12440"
                     /old_locus_tag="B9W61_12420"
     CDS             26566..27873
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rfbH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446985.1"
                     /locus_tag="B9W61_RS12440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_12420"
                     /product="lipopolysaccharide biosynthesis protein RfbH"
                     /protein_id="WP_087765132.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.6e-97,
                     bitscore: 325.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEHRTRVLEETRKHHQSVRDSGEFVPGTTEIWPSGAVLDEDDR
                     AALVEAALDLRIAAGPLSKRFESDFARLLKRRKAHLTNSGSSANLLALTAYTSPQLGER
                     RLLPGDEVITVAAGFPTTVNPILQNGLVPVFVDIELGTYNTTADRVAAAIGPRTRGIMI
                     AHALGNPFEVAEIAQLAADHGLVFVEDNCDAVGTTYQGRLTGTFGDISTVSFYPAHHLT
                     MGEGGIVTTSDLKVARIVESLRDWGRDCWCEPGHSDTCLKRFDHQLGALPAGYDHKYIF
                     SHVGYNLKSTDLQAALGLSQLRKLDGFIAARRHNWRRMREGLDGVRHLLLPEATAGSDP
                     SWFGFVMTVGPDAPFTCGELTGFLEQRKIGTRRLFSGNLTRQPAYHQQPHRVVGELTNS
                     DIVTERTFWTGVYPGLTDEMTDYVIASVREFVAGRR"
     misc_feature    complement(28633..28648)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.54"
                     /tool="antismash"
ORIGIN
        1 gtgagcccgg cggggcgcac gcggtatgac ggcaccggct atccaccctc ttcggccccg
       61 gccggaaccg tacggggtgc ccgaaccgcg gcggccaggg cgtcatggcc gtacacccag
      121 cgcagcccct ccagccccga acccgaggcc agctccgcgt cacgcgcccg ctggagcggt
      181 ccgtccggca gatgcgaacc gaccgccacg gaccgggccg accgctgcag gcgctcggta
      241 cgcgggatcc gcagctcctc gtagcggcgc agcgccgccg ggaagtcgcc gcgcgactgc
      301 gccagcgtcg ccgccagcgc gaaggcgtcc tcgatcgcct gattggcgcc ctgcgcggcg
      361 aacggcagca tcggatgcgc cgcgtcgccg agcagggtga gggcgtcgga cgaccagcgc
      421 gccagcggct cgcggtcgtg cagcgcccag cagccgatgc cgccccccgc cccgagcagc
      481 cgggtgaccg tggggtgcca cccctggaag gcctcggccg cctcgccccg gtccccgagg
      541 gcggtccagg actcgcccgg aagggcggta ccgcccgtgg tggccgcgaa gctgatcagc
      601 cggccgccgg agaccggata gcagacgcag tgccggccgg gtcccagcca cacctggacg
      661 cggggctcgt cggccagctc cggcacccgc tccaccggca ccagaccccg gtagatccgt
      721 cggccggaga agaccggggc gtccgcggcg aggtgctccc gtaccaccga gcggatgccg
      781 tccgcaccga ccaccagctc cgatcggtgc tccgagccgt cggcgaagcg cagcacgacg
      841 gcgccgggct cctccgccag cccggtcagc cggtgaccgg tgcgcaccac cgggccgacc
      901 aggtcacgca gcgcccggtg caggtcggcg cggtgcacgg tgacgtacgg ggcgccgaac
      961 agcttctcgc actcctcgcc gagcccggtc ctgcccagca gccgcccgtc gtcccagcgc
     1021 agcagatcgc gggagagcgg gcggacgccg tactgccgca gggaatcgga gagccccagc
     1081 cggcggagca gccggaccgc gttcggcgcc aactgcaccc cggcgccggt ctcggcaggc
     1141 tgttcggcgc gttcgaagac gcggcagccg atgcccagcc gcgccagtgc ggcggccagg
     1201 gtgaggccgc cgatgcccgc gccgatcacc gcgatgtccg gcgccggggt gctactgctc
     1261 atggcagaac tcgtcgatcg gatagcccac atggcggtcg gcggtcggca gatgccccag
     1321 cacccggtcc ccggggcgga gttcggtgct gttgagcacg gcgtcccccg gccccagcac
     1381 ccggacgtgc cagtcgtcct ggaggatcag attgacctcc tggccacccg cggccaccgc
     1441 gtcgatggag atcagcggac gcgtctcgat cttgacccgc cccaccgcga ccgtccgggt
     1501 ccggcccttg gtgtccacgg ccatcacctt gctgccggcc ctcagttcgc tgaggtagcg
     1561 ggtgcgtccc tcgtcggcga gggtgtacga gtggatggcg cccgcgttga cccggaaggg
     1621 gcgggtgggc atgtacggca gcggatgggt ctcgctgacg cagaggatca tgcccttgga
     1681 gtgcgagccg accagaatgc cctcgtcctt gcccagatag gagcaggtgt ccacgcaggc
     1741 gcgctccccc ataccgatgt gggacacggc ggtgacctcc agctccacaa ggaggagttc
     1801 gccggtgccg ccggccgcgg tcgccttgag cgcggtggcg tcgcccacgc tccggccggg
     1861 catcagcacg ccgtcggagc cgagttggag gcagccgaag atgacagcgg cctcctcggt
     1921 gttcttcgcc atggtgatga tggcgccgtc ggcgtcggcg gcggcggcga tcacgatctc
     1981 cagcgggatc ttggtcgggt cccggaagtc cagcacgctc cagcgttcgg tgcgggccgc
     2041 ctcgatggcc gcgtccaggc tctcggcgtc ggtgatctcc accagccgcc cgaactccac
     2101 gtcgggagcg gcctcggcgg cccgtgcccg ggcggaggcg tccccggcga ggatgacgac
     2161 cccggcggag ccgtagctcg cgggctgctt gcccggcgga ggcatcagca ccttggtgac
     2221 ggtcggcggc agcccctcca gatcggccgg gtcggcggcg actatgccgt cgacccgctg
     2281 gtgcagcgcc tcctccacga tggcctgccg ggccttgccg gccgaacgga tgtcaagcca
     2341 gcacagtttc tctgagctca ctgccgtgcc cttcctcgat gtgaccgagc gtgcccccgg
     2401 ggcggtggtg gacgactcca gccacccggg cggccatcgc cccggggtcg ggggactgga
     2461 agatgtttct gcccatcgcg actccggccg cgccgcccgc gacggcttca cgggcgaagg
     2521 ccagcacctc gtcctccgtg tcgcgctgcg ggccgcccgc gcagatcagc gggatcgggc
     2581 aggccgctgt gaggtcccgc atctccgccc gcgtgcgcag gcagggggcc ttcaccaggt
     2641 cggcgcccag gtcggccgcg agggtgacgg cgtgggcgac gagttcgggg tcggcggggt
     2701 cggtgatctt cggcccccgc gggtacatca tcgccagcag cggaaggttc cagcggtcgc
     2761 actggtcggc caccgctccg aggtcggcga gttgccgcgc ctcttcccgc gaccccatgt
     2821 tgatgtgcac gctcaccgcg tccgcgccca ggcgcagcgc cgcctccacc ccggtgacca
     2881 ggtgcttggc gtccgggtcc ggcgcgtgcg cggtgctggc gttgaggtgc aggatcagcg
     2941 acatcgcggc gagccgggag tggtcgatgt ggcggacgct gcccttgtgc accacgatcg
     3001 cgtccacccc ggcgccggag agctgtccgg cgagccgatc gatgctgctg ccgcgcggca
     3061 ccaccgggcc gtcgctgagc gagtggtcga gcgggacgat catcagccgc cgggggtcgt
     3121 ggtggaacag ccggcgcagc cgcacagcgc ggccgaagtg ctggtgtgtg gtcatggagt
     3181 tcccttcggc ggtgcgccgt cgtacgcctg ccggccgtta ccggagcgca gacaggccag
     3241 gtcgggcttg ccgcgctcgt tgagcggcat cgagtcccag aacgtgatct cggcgggagc
     3301 gtgcagcggg gagagctgct cgccgacgtg ggtgcgcagt tcctccgcgg tggaggtccg
     3361 gcccgccctg aacacgacgg ccgcgtggac gtactcggtc cggtccggat cccgtacgcc
     3421 gtggacggcc gcattccgta ccgccgggtg ggagagcagt gcgcgctcca ccgcggcggg
     3481 atatatcttc aggccgccgg acttgatgac ctgcccgctg cggccggtca gccgcagata
     3541 gccgtagcgg tcccagcggc cgaggtcgcc ggtgtccagc cagccgtccc gcaggacacg
     3601 ggcggtctgc tccgggtcgt tcgggtagcc gtccatgacc gtggaggcgc gtacccagat
     3661 ctccccggac tccccgcgcg gcaccgggtc gccggtgccg ggctcgcgca cctccacctc
     3721 cacccagggc agcggtcggc ccacgctgcc caggagttcg ggttccaggt ggtcgaacgg
     3781 gctcagattg ctgatgccgc cggcctcggt ggtgccgtac agctggacga gcaccgggcc
     3841 gaacacccgc agggcctcgg cgatccggtg cggcgcggcg ggggtgccgc tgtagacgac
     3901 gcggcgcagc gaccacaggg cctccccgac ggggcccgag ccgggaggct gctcgtggcc
     3961 cggcgcgtcg gccagcagtt ccgtgagccg gtacaggtgc ggaacggcca gataggtgtc
     4021 ggtgacgccg tggtcctcga aggcccgcag caccttcgga gcgtcgaagt cctggtgcag
     4081 gaggacctgg ccgccggcgg ccagcaccgc gtccgccatg gctccgatgg tgtggctgag
     4141 gggcgtcacg gcgaggaaca cccgccgctc gtccggttcg ccgctcgccg ccgaccggac
     4201 ggtgctgtcc cagaccccga aggtctgatg gatgctcttc ggcgtaccgc tgctgccgct
     4261 ggtgaaggcc accagtgcgc ggcggtcggg ggaatgggcg gggatttctc cgagcggctc
     4321 gtcccggtag gacagcgtgt cggggcactc ggcggcgccg accccgtagc ccagcaggcg
     4381 ggggccgccc ccggtcagcg acaccagggc gcgggcgcgt tccagatggg gggcgtcgac
     4441 gaggatcacg gaggtgccgg tctcgtcgag gatccgcgcc tgggtggcgg cgggcagcgg
     4501 gaacgcgtcc gagcgggggt tggccgagcg cacctggacg accgcggccc ccaggaggtg
     4561 ggcggcgtag cggccgatca gcatcgcggg gtggttgggt tcggtgagca ccgccacggt
     4621 gccgccgggg gtcagcccgg cccgccgcag gcccaccgcg gtcgcgcgta ccgcgtcggc
     4681 cagcgtcgcg ccgtccagcc accggccctg gaagtacagg gtgggcagcg aaggttgacg
     4741 ggccagccgc cacagcacgc gccgcgcgta gtgctcatgt ccggcccagg agtcgggcac
     4801 atcaatcggg aacgtcacga ccatccgttc ggggccgggc gccgggcccg ccctccgctg
     4861 ggcggaccac ccggtggtgc cgcctgcgcg gtgggcgctg cgcccgccgc gcaggcggca
     4921 ctgcgccgcg ggatcagcag cagcagcagg aggacgagga ggaggaacag caggtcacgg
     4981 ggatgctcga cgcggccatc tccggcagcg cgacaccgtc cgcgatctcc atcgtgtcca
     5041 gctcctcgat gtcgaaggag tcgaacatcg cgtccacgtc cgcggtctcc agggtcgatc
     5101 tcatcttgtg tgtaccccca agctcttggt ccgccggccg ggagaccggc ggtgcgtgtg
     5161 ttttccaacc ggtaccccgg cacgcgtttt cccctgcccg acgccgactt cgtcagcggt
     5221 gcacgccgga cagccgctta ccggatgctt gttgcccagg tggcgctgtc cgcgcgtcgg
     5281 gagacccgac gcacggacag ccggtgtccc tgcctcagca gcaggaggaa gaggaggagc
     5341 agcagagggg ggcgttcagg tacgacgcgc ccatctcggg cagcgcgacg ccgtccgcga
     5401 tctccagcgt gtccagctcc tcgatgtcga aggaggcgaa catcgcgtcc acgtccatgg
     5461 tctccatggt cttgctcatc tcggtgtacc cccaagctct ggcccgccgg tcgggagacc
     5521 ggcggtgcgt gtgatttcca accgctgacg gcacacgatc gccctccggg cctgcactga
     5581 aatcgatcag caattccccg gacagccgca tgccgaaagc ctgttgtgcg ggtggtgccg
     5641 gctgccgccg gatcggcggc aggatgagaa cgagcggaac agcccacgag accggcggtg
     5701 cctacgattt ccaaccggta cccggcacgc aatgacccgt gaccgggcgc tgacatttgt
     5761 cagcgttccc cgccggagac cgacggcatc cgccgatgct cacagctcgt cgccggcgct
     5821 gtccgcgcgt cgggagaccc gtcgcgcaga cagctggtgt ccctgcctca gcagcaggag
     5881 gaagaggacg aggagcagca ggtgaagtca cccttcgagg cgcccatctc gggcagggcg
     5941 acgccgtccg cgagctccat ggtgcccagc tcctcgatgt cgaaggagtc gaacatcgcg
     6001 tccacgtcca tggtttccac gatcttgctc atcttggtgt acctccaagc tctggccgcc
     6061 ggccgcgaga ccggcggtgc atgatttcca accggttcgc ggcacgcaat tacccttgac
     6121 ctggagctga tatttgtcat caattcctgc gggtaaccgc ctgccgagta tgcgtttctt
     6181 ctccgtggcg ctgtccgcgc gtagggtgac ccgtcacgcg gacagctgtg ccgctacgtc
     6241 agcagcagga ggaggacgac gaggagcagc acatggtgtt gcccgtcgag gcgcccatct
     6301 cgggcagggc gacgccgtcg gcgacctcca tggtgtccag ctcctcgatg tcgaaggagt
     6361 cgaacagggc gtccgcgttc atcgcctcaa tggccatgct cattgacgtg ttttcccttc
     6421 ttgattaaga ctgccattcg gtagaagtgg caccttggat aatttcggtc acttccggcg
     6481 ctggcaatct ctcgcgaagc gccgctgaca tttgtcatca gcctccgcct ggtagccgct
     6541 cgaaggggcg taaatgtcgc tttgatgaat ctgtacggtg agtctcgatt atcacgactg
     6601 gacccgtacg gcccggacac cgggtattca ggacaggaga agcatgaacg ggatatctgg
     6661 gtcacgcggt cggggcgccg gcgctccgga ggccgatgtc ctggtcgtcg gctacgggcc
     6721 ggtggggcag gtgctctcca tcctgctggc ccggagcggg tggcgggtcg tcgtcgtcga
     6781 gcgccatccg gaaccgtaca gtctgccgcg agcggtggcg ttcgacgccg aggccgcccg
     6841 gacactcgac gccatcggcg tcaccggccg gatcgtggac atcaccgaac cctcgcagga
     6901 ctacgtggtc agcgacgccg ccggacggca gctcctgcgg atcgggctgg gcggcacgga
     6961 cgggacgggc cggccggact ccacctccgt ctaccagccg ggtcttgagg ccgcgctcgc
     7021 ggcccgcggc gaggagctgc ccacgctgcg cgtgcaccgc ggcctgcgtg ccgtggagct
     7081 gaccgaatcc ggctccggcg ccgagctggt cgccgaggac gaacgcggcg gcgagcggcg
     7141 gaccttcacc gcctcctggg tggtgggctg cgacggtgcg ggcagcttcg tgcggcgctc
     7201 cctgggcatc gggtgggccg attccggctt cgccctggac tggctggcct gcgacgtggt
     7261 gccggaccgc ccggaggact tcccgccgtc caacctccag atcgccgatc ccgcccggcc
     7321 ccgggtggcc gtctcctgcg gaccgggccg ccgccgctgg gagttcatgc ggatgcccgg
     7381 ggaggaccgg gcggagttcg gcaccgagga gaacgcctgg cggctgctgt cgatgttctc
     7441 cgccaggccg gacaacgcca cgctcacccg ccacgccacc tacaccttcc gggcccgcaa
     7501 cgccgagcac tggcgacgcg gacgggtgct gctggccggg gacgcggccc atcagatgcc
     7561 gccgttcgcc ggccagggca tgtgctccgg cttccgggac gccgcgaacc tcgcctggaa
     7621 gctcgacctg gtgctgggcg gcagggccgg ggaggcgctc ctcgacagtt acgagcagga
     7681 gcgccgcgcc cacgtgcagc acgcgatcga cctgtccgtg cggctcgggc gcctgatctg
     7741 cgtgaccgac ccggccgcgg cagccgacag ggaccgggcg atgaccgccc gctcccccgg
     7801 ccaggaccgg ccggccgaac cggtgcgccc cgccggcccg gcccgctccg cgagaccgct
     7861 gggcgagcac ctggccaagg gcttcctcgc cgacggcgga cctccggccg gtgaactcac
     7921 cgcccgggcc cggctgaccg gccccgacgg tccgggcccg gccgactccg tgctcggccc
     7981 cggcttcgtc ctgctgtgcc gcgggaacct cgcggacacc ctgtcccccg ccgcactgga
     8041 gaccctgcgg ccggtgtccg gccgggtggt gaccgtcctg cgctccgacg ccggttcggc
     8101 ccccgggccg gacacggtgc tggacaccga cggccactgg ctgccctggc tggaatcgct
     8161 gcaggccggg gcggtcctga tccgccccga ccactacctg ttcggcgcgg cccccgacgc
     8221 ggacgggctc gcggcactgc tcacggagtt cgggcggcgg ctgcgcccgg ccggctgagg
     8281 gccgggcgca gccgccgccc gaccggctct cagtggtagc ggcgtccctc gtcacgctgg
     8341 taggcgtaga aggcgagggc cgccaggccg acggtccaga ccacgagcga cacgatggcg
     8401 accgggttga tgtcgtagtc gccgacggtc gcccacatca gctcggccga gccccgcgtc
     8461 gggacgaacg gggcgatcgt ctcgatgaat ccgggcgcct cgcccgggcc ggccagcagc
     8521 cctcccgcga aggccagtgg caggaagacg agctggacgg tggcgatcgc cgccttggtc
     8581 gagagcaggt agccgatcgc cagccccatc atggtgaacg gcacggagac gacgatcacc
     8641 acgccgatcg ccagcaggaa gcgggccggc gaaagggtgg cgggggtgaa gaacgccgcc
     8701 acgatcacga ccgggaccat cgagaacagc atcatcgcga gaccggtgat gatgcggctg
     8761 ccgaaccgca ccgccgggcc gatcggaagg gttcgggtgt aggggtccca gggctgggag
     8821 cggtcttcgg ccacaccggt gccgtggccg aagagattgc tgatcatcgc cgcgaagacc
     8881 accatcgagg ccgtggcgag ggtggccccg acagggtcgt ccttggtgtt gggcaccacg
     8941 aagaagatca gcgaggcggc cgggaagaag gccgcgccga tgatcgccat ggggatgcgg
     9001 ctgagctcga ccagctggta gcgggcgtgg acaagggtca gtgatgacat ggcctcaagc
     9061 actttcgtgg gaggtgcggt ggatcaggac tgggagatca ccaggaaggc ttcttcgagc
     9121 gtggcctgct ggacggcgag gccggagaac tccacgccct gccgcaccag tgcccggacc
     9181 agctgatcgg cgtcgtgggt catcagctcg acccgctcct ccgtccgctc ctcgctgatg
     9241 acgcccggca ggtccggcag tggtccggcg ttcatggaca cgcgctgcat gtgggccatc
     9301 ccccggatgg cgcccacggt gtcgtccgcc cggatgcggc cctgggcgat caccaccacc
     9361 cgcttcgcca gggcctcgat ctcctccagg tagtgcgtgg tgagcaggac ggtgccaccg
     9421 ccctcgtgga actcgcggat gcggtcccag agcatccgcc gggactccac gtccaggccg
     9481 gtggtcggct cgtcgaggat gaccaggcgc gggcgcccga cgaacgccag ggcgagcgcc
     9541 agacggcgct tctggccgcc ggagagtccg ccggtctggc gccgggcctc cttggtcagg
     9601 tcgaaccgct ccagcagctc gtcccggtcc tcggtctcct tgaagtgcgc ggccacgaag
     9661 tcgaccgctt cggccacccg cagggtcggc gggacgccgc tctcctgcgg ggtgacgccg
     9721 atgaaacgcc ggttggccgg gttcgtgggg gagcctccga acagctcgat gctcccggag
     9781 gtcggcttgc gcagccccag cagggagttg agcagcgtgg tcttgccggc gccgttgggc
     9841 ccgagcagac cgatgaactc gccctcccgc acggtgaagt ccacgttgtc cagggcgacg
     9901 gtgtccccgt agtgccgggt gacgccgatg gcgcgggcga tgacggtcgg tgtgggggga
     9961 gcccctgcgc gggcggtggc ggtggtgggg ctggtgctca tcagtgctcc tcggttgaca
    10021 ggaccgcgcc gctctgcgcc ggtccggagt ggtcggaagg ggaggcccct tcgggggccg
    10081 accgggcggg gaagagcctc gccagccggg cataggtctg gtattcctcg accgcccgca
    10141 ggccgaggcg gttgtgcagc atgtggacgt gggagacggt gacctgtgcc gggtggagcg
    10201 gggtctcccg ccgtatccgg tccgacagtc cggtgagtgc cgcctgccac ggcgccagcg
    10261 ggcccgtggt gtctcccccg gtcgctttgg cccgcagctc gtcggtcggc cgggcggccc
    10321 ggtacagctc gtcgagctgt tgctccgtgt agccgtagcc caccgtccac gtacgccagg
    10381 cgcgcagtcc gtgatcgtag aaggccgcct gttcggcggg gtcgtcgccg agtgcccgcg
    10441 cggcgcagac ggtggcgcgc agggccagca gggcgcgggc cccgctggag ggtccgcgcc
    10501 ggaggaaggc gaggaccagc ctgctggaga gctcgaagag ccgttcgctc tcgggcatca
    10561 actcccggcc gccgtacctc tcgtactccg ggtggtaggc gaagcggtgg acaccgggct
    10621 ccagcatgcc ggtgacctcc tggtgggagg gctggtcccc ggccgtggtc atggcggcgg
    10681 cggtccgcgc gtagtccgcc gggtccatcg ccgtctcgcc ctcccgcggc cgcccggctt
    10741 ccgcgagccg ctcggcgagg agccgctcgg ccgaagccgc ctggtcatca gtcaagtcgc
    10801 cgatgcgcag gcggacatgg ggcccgccgt gccagtagcg caggaagaac cacgggcggc
    10861 cctgcagggt gggcaacacg gatccgaccg cgtcgaccac cacccggtcg tgggcgctcc
    10921 ggtcgccgct cggtacgtgc agatgccagg tccgccacac ggtgtcgggt ccgccggggc
    10981 cggcgccgcc cccggcgcgc gcggtctcgg atgcgtcggt caacttctgc tccctcgtca
    11041 caggcgtaga tcgcacaaca gcccctcgaa gcgcggggtc ccggtgatgg cggcgcagac
    11101 gatcatctcg tcggggtcca ggccgaggat gtgcctcgtc gggacttcct ggaaggcccg
    11161 cgcgggcctc gcgtacagac cggtggcggc ggcggccagc gagatgccct gggccgccca
    11221 gcccgccgcg tactgggcgg cggtgaagcc gccggggccc agccggtcca cgagccgtcg
    11281 tgggtgcgcg gagaggaacc acaccgcgct cgcgtgccgg atgtcgcccc cggcgtacgg
    11341 ggtgacgggg tagccgtagt gcgtctccag ctcggccgcg gcaccggggt gggcccggtg
    11401 caggacaggc cggccgtcct tcaggtgcca gacgccgtcg gcgtgcccct cgatgccctg
    11461 gaacacggcg gtcaggcgca gttcctccca ggcggcggcc aggtgcgggc ccgggggcgg
    11521 gacgctcagc cagctgacgg cctcgcgcag ggtccgctcg ggtaccggtc gtctgcggcc
    11581 ggtcatgccg tacatgccgc gcggcatccg ccccgcgctg cggcgccaca gcacctccgc
    11641 ccaggacagc gccccgtccc ggggcaggtc ggccgggacg gacgggccga gcggggcggc
    11701 cggacccgtg aagtcctggg ctcggttgac ggtcaggata ccgtcgagga ccgggtcggc
    11761 ggcccgctcg gccggggccg cggcgacgga cggcccgccg tcctccaggg ccaccgtcaa
    11821 cggcagggac cattccgact cgggcgtcag gccgaagtcc gtcagcaggc ccgccgcgtc
    11881 ccggtccggc agccgcagcg ttccggacag gccgaagagt tccattccca ggcacaactg
    11941 gcgcaggttg atgccgagtt cgaggccgat cagggagctc cggaaccacc ggtaggagtc
    12001 gggcagccgg gtgtacctcc cggccagcgc cacctccagc ggcccgtcgg ccccgtcctg
    12061 gcgtcccaca ccggtcagcg cgtgccggta gaggtcgagc acccggcggt ggcggccgtc
    12121 ccggacgaac acctggacgg ggaacttcgc ccgcaccgat gggtaggggc ggtggtcgtt
    12181 gaacgggttc tccggctccc gccgttgcag cccgaagccc gcgaccaggg cgtgcccgag
    12241 ggcgtcggac ctgtcgcgcg gggagcccgc ccggccgtgc ggataggccg ccctctccag
    12301 cagctcggcc gtaccccggg gcaggggcgt ccggtcgccg agcgccgcct ccgggagcgc
    12361 gggcgcgacc tcggtgtccg ggcggggctc ggggacgacc tccgcatcca cccgcacacc
    12421 gagccccgtc gcgtgggtga accaccgcat gtcgcgcgac atgacatcgg catcgtccgg
    12481 gatcggtgac gcagggccgc cccggtcgct ggtatctgtc atggggaact ccgtctgcct
    12541 cggtggttcg gtggacatcg gcgcgaattc gccgctcgcg ctgggcctgt gggacgtccg
    12601 gggatcaggg gaaggcgtgc gggtcgtagg gcggcgacag cttgccggag ggggttccga
    12661 ccagtgccgc ctccagcctc ggcagcccgg ccacccgttg ctgggcctgg ccgaagcaca
    12721 tggggacgat gcccggcacc acggccctgg cggcggccag gccgatgtcg gcgtggtccc
    12781 gtgtggtgga gtccaccagg acgatccggt ccagtccggc gtcggcgtac ctcccccgaa
    12841 cgtagtccag cgccccgagc acatcacccc cggcggcctg ttccagccgg tccggccagc
    12901 cctcgaacgc ctccgacagg ctcatctccg gcccgcccag cacggccgtg acccgctcct
    12961 tcatctcggg cagcgcgtag agccgcaggt ggtcgtccat ctcgtcgacc gaccaggggt
    13021 cggccagcat cggttcggca tcggagcggt cccaggtcaa gcgctcggtc gccatctggg
    13081 tcacctccca cagcgccccg cggagcgcgg agaccgggtc gatgccggag cccgcggcgg
    13141 agaacgtggc cgggaacgga gcgcgcgtgt tgaccgccat cgcccagacc accggcaggt
    13201 cgatgtcctg ggtggcgcgg agcaggtgga cccggaagcc gcgcgacgcg gcggtcgcca
    13261 gcagcccccg ggcgaccgga tcggtgatcg aggagtgggt gatctccggc agcgggaggg
    13321 cgcggtggaa gctgatcagg aaggcgtccc gctcggccag ttccagcagg gagtacagcg
    13381 cggcctcctc cagacaggag ccgaccgcgc agccgctgga ggactcctgg tacaggtgcc
    13441 ggcgcggcgg ggcaccgtgc cggcgcgccg cccgctgctg ccgtccgtag cggtagtcgt
    13501 actggaagaa ggcgagttcg gcggggacga gccggggccg gccgtccgcc aggtcgtgcc
    13561 cccacgccca gtccatcggc gtgtcgtccg tgacccgctc gatccgcgcg gtgggacgtg
    13621 ccgcctgctc ctcggtgtac tcgccgaact cggcgggccg gatcgccacc tccgctccgc
    13681 cctcggtgcg gacgagttcg gcgtacgaga ccccctcgac caggggcgcc tggtgcggga
    13741 agcccgaaag ccgctcgtac acctccagga tggcgatcgg gtccgccctg gcgaaggtcg
    13801 tctcgcgggc gtagccgagg gccaccgcgt cgggctggag cgccatgctc atggcgaagg
    13861 gggccagcag ctcccgttgc tgcgcgagga ccggtccgaa gcgcggatcc accaggcgtg
    13921 agcgcagggc accgggccgc accagcccgg ccccggccgc ggcccggccg gggttgtccg
    13981 cggcggcggg gcgtggtcgc agcgccaggg gctccggcgg ccggcccacc gggtgttcgg
    14041 ggatctccgg cgcacacagc gggcaggcga agtggcgggg tacgcggtgc gtccgcgtcc
    14101 cccgcgctcc caccgcgtac aactcccccg gccccagggg gcggtcggcc agccgtgcca
    14161 gcgccgcgcg ggtgagctcg ggaaggaacg gacggcgcgg ggcgacccgc gaggtgggcc
    14221 gggacaggtc gtcggtcagg gggtggtcga tcacgagccg ggagcgcagc tcggcgcagc
    14281 ccgcgcagcc ggagtccgtc cccggcaccc agcgggggcc caccagcacc tcgtcgccgt
    14341 agacgcggac ggacagatgc tcacgcccgt cggcggaccg cagctgctcg cgttcccagt
    14401 ccaggtccca gccgagattg gcgccgacgg tgccgtcacc aaaggcgccc agcggctcca
    14461 gcacggcacg ccattcggtg ccggcgtcgt cggacagggc gggtgcgcag accacggtgg
    14521 tcgggttctc agccatggtc ccgctcctcg atgctctctt ccgtaccctg cggctcgccg
    14581 acgaggggga cggcccggac ggcgcccgac cacaggggca gcgcaccggt caccgggtcc
    14641 ggtcgccgcg gggtgccctc gtagcggagc ccggcggcct cggccgcgtc cgcgacccgc
    14701 ttgcgcagcg ccgcctgctc ggaggcatcg gcgaacagca gggcgtcggt gtgcacgcct
    14761 tcggccaggg ggcccgcgcc gggcaccccg tgggcctggt gccgggccag cgcggtggcc
    14821 agcgcacggt gcaccgcctc cgtgtcgtca cggccccagc tccgcccggt ccacggccgc
    14881 gggccgccgg aggtccgtac ctccgccagc gtccagtcca ggccggggtg gcgcagcagg
    14941 gtcagcgccg gggccggcat gccctcttcc tccagcaggc gcagcagcgg caccgagcgc
    15001 gcgtccacgg cccccacggc cctggtcgcg tacggcacgg cttcgtcggc catcagccgc
    15061 agcgcgccgt ccagcagcca gtgctcctcg gtgagcccgg cggcggcggt gcccggggtc
    15121 gggcaggcgg cccggagcgc ggcgagggcg accgcgaccg tcgccgtccg ctgctcctcg
    15181 gcccaggcga ccacggagcc ggcgtcgccg tcgcgggcgg ccatctcccg cagggccagg
    15241 ggcatctggg gcagctcctc gccgccgagc agcgcgaggg gtccggtcca ccgtccggtg
    15301 agcgcggtca ccgcctcgac ggcctcgtcg ggggtgggcg gcggtacggg ttcggcgccg
    15361 gcctcgggcg cggcggtcag gaagcgccgt tcggcggctt cgccggcggc ggggccgggg
    15421 gccgtgaggt gcacacggtc cgccgtcagt tcctcaccgt ggaggacatg cgcctcgccg
    15481 ggcggcgcga tgcccgcgag ggtgtcgaac agcagctgtc ccgcgagcgc cccggccagt
    15541 gccgcggccg tggggtgggg gacgggggcg gtcgcctcgt ccacggccca gcgtgcggcc
    15601 cggcggacga gcgcggccga accggcgagc gacgcaccac cgggggcgac ggggccgacg
    15661 gccgcgacga gtccgtccca gcgcaccggg accagcggcg cccccgcggg cagcagggcg
    15721 gtcagcgctt ccgcggtcac gccgtcgtcc gcgccggggc agtggaggac ggcgtccggc
    15781 ggcacgggca ggtcccccgg gtccgggagc gtcgcggtgt cgccgagcgg cagcagccgc
    15841 attcccagcc gggaggcggt ggcagcggcg gcgtcggggt ccggggtggc cagcgtgagg
    15901 ccggtgaccc cggcccggtg cagtccgcgg gccgccggca gcacggcatc ggccggaccg
    15961 cacagcagca cctcggtggt gcgcagccgc tggaagacgg cgtacgggtc ggcgcactcc
    16021 gtctccaggt gtgccagggc ctccgggtag cgggcccgga tctcggccga cggctcgggc
    16081 acggtcagcg cgtccaggtc gagcaggagg ccgcgggccc gcagctcgtc gacgatccgg
    16141 cggacgacgg gacgggcccg ttcgctgccg agggcggtga ccagctcgtc ctcggtggtt
    16201 cccgcttcca gcagcggcac acagatgtcg gcgacccggt agagcagttg ggggccgctg
    16261 atcacgaact gggttcgggg gccgttgaag tagacccctt ccgagaccgg cgcatagtgc
    16321 agatgggggc gcgcgcgtag cgtcatcggg tctttcctcc gtactggaag gggccgccgg
    16381 gagcacggcc gatgtcgacg atccactcca gggcgtgcgg gctgtccgcc acccggggca
    16441 gcgcctcctc cacgtaggcc gcctcgcccc gctccaccat ccggggcagc acacgcacgc
    16501 tgagggcgct ggccagatcg acgtactggg gcttcttctt cctgccctca ccggcggccc
    16561 ggcccgcgcc ggcggcctgg ccctcggcgg agccgtcacc gggcggcggc ttcaggacga
    16621 cctcctcggg cacgccgtgc cggttgcgcc accgggcgag cgccagcagc cggtcgtgct
    16681 cggcgggccc cgctgccacc gcctcgtcca gctcccggcc cccgtaccag cggcggcggg
    16741 ccagcatggc cgagccgacc tggaagcgcg ggcaggccag cgtgcggtcg ccgtcccacg
    16801 ggcgctcggc gtgccggatc gccacgaagg gttcgcgcag cacgccgccg gagtagagcc
    16861 agttggccag ccggagcggt gccgggagcc tttccgggtg cccggtgccg agcgagagca
    16921 tgtgcagcgg gcggccgtcg gggtccagga tgctgagcgc gtccgtgtcc gggtcgtggc
    16981 gcagtcgcag ccggaaccag tcgtcgggcc tcagccggtc cgggagcacc ggcgggtgcg
    17041 cgttgacgtt gagccggtgc agacccgggt cctcgaccag ccgcccgccc tgctcggcgt
    17101 agcgggcgcg gagctgctcg cggaagtggg gcagggcgcg cccgccgagg gcgcggtcgg
    17161 gtccgaggaa cctgccgtag agcatgccgt ggccggcgta ggcctcgttg aacagcagct
    17221 gtcgccgcca ggtctgggtc agcacgccgt agcggaggtc gccggtccgg aagcggtcgg
    17281 gcaggcccgt ggtcaggtcg agggcctggg aggcgctcca gttgacggcc tcgccggtgg
    17341 cggcggcctg gtcgatggcg gcgatcgcgg tgtcgacgat gttcgcccgc agggcgtaca
    17401 gccggtccaa cgagcggtcg gccggaccca gttcgccggg aggctcgttc tccgggaggc
    17461 ggtaggcacg ccggtaggtc tcggcgctca ggtagtccgc gtggtcgctg agggagacct
    17521 cggcgccgac gccgaaccgc tcgacgaaga cggtggacag caacgcccgt atgtcgtgca
    17581 tccagtcgaa gacggagagc agggccaccc cggcggcgag gtcgtcgagc tggctccgcc
    17641 agtcggcggt ggacacccgg acgtcctcca gtacggcgtc ctcctcgatg aggatctgcg
    17701 ccggccgtcc cgcctcgcgg ctcagcgtga ccagggtgtc gcgcagccgg ctcagcgcct
    17761 cgggccgttc gtcggcggag ttgtcggcga gcccgcgcag ttcggcgccg gtccgctcca
    17821 gcagtctccg ggccgtctcc gggaccgccg gaacggcggg gtcgagcagc tccgggaagt
    17881 cggccgcgcc gtcctccggg cggctgcggg tgcacaggat gccggcgccc accgcacgcg
    17941 ccagggcctg ccgggcgagt tcgggggtgc agccggagcg tgcggcgaag tccgcgacga
    18001 cgtcggccac gcggcgcggg ccgacggcga cggcggccac cagcagcccg accgcgcccg
    18061 tgaccttggc cgacaggcgg cgcaccccgc cgtcggctcc gggctgcagg aagtacagga
    18121 gatcgccttc ggccgacagg tcggccgtgg gcggcagttg gagcagggtg tcgggggtga
    18181 gatcgccgtc cgcggtgtgc agtccgccca gtacgtagtc gagcatgacg cggtccagcc
    18241 cctggaaggg caccacccgc ccgaactccg gggcgtccgg gcccggtccc tccggcacgg
    18301 ggacggcgag cccgatggcg gtgaagcggg ccatcgggct ggtgcggacc atggcccggg
    18361 tgacgtactg gaccagcccg cgctcggact tgcggagccg ggtggggacg ggctcggtgg
    18421 cggcgacggc cgccctgtac cgttccgcgc cggccgccgc ctccggtgcc accagcgtca
    18481 tcgagtgccg caggctctcg tcgcccagca gcccggccag cgtccctcgc tcggcgtcca
    18541 ccgcccgcgg gtagtggccg accacgtcgg cggcgtgtgc ctcccgccgc tgccgggcct
    18601 cccaccagcg gccgaccagg gggtggtcga cgagcagtgc cggccgtggg gcggtgtcgt
    18661 tgtggatggc gcggcgcaac acgatgagct gcccgcgcgc ctcccggtcg gtggtggcgc
    18721 cgatcatctc gtagagcgcg tcggagcacc ggtcggccag ttcgcgcacc tcggtcgtgg
    18781 ccccgtccag cgtgcggagc gccgccagca gcccggggtc cgcgagcctc ctgcggcgca
    18841 gcgggttgag gcgcagcatc cacaggggct ccgcggtgtc gctcattccg ccgccccggc
    18901 ggtggcctcc gccatctcct gccgtgtctg ctccagccgg tcctgccagg aggagccgag
    18961 gacctcgtcc accagttcgg cgacggcgaa gcagaagtag tagcggtgca tgggcggtac
    19021 gcccagcagc ggcagttgct ggtagaagag gttgacgagc agccggtagg aggcgaacca
    19081 cttcggcggc gaggcgatga cgccggattc gtccatcgtg cggtggaagg cgctgggttc
    19141 gtggctcacg cggccgtcgc cgccgggcgg gcccatggtg tccaggtcga aaccggcgcc
    19201 gagaccgtcg atgtcgtcca gggtcaggct tccctgggcg accgtggcgt cgaaggcccc
    19261 catggaatag gcgaaggcgc gggcccaggc cgccgtcccg tggtcgggcg taccggagag
    19321 cgcccgctcc acgacgggcc gcaggcgggg ggcgtcggcg gccagccgct gggcgaaggc
    19381 ggggcggggg tccttgcggg cggccgccca ggcgaagaac gcctcggcgt gcgagcgcat
    19441 cgagaacgcc ccgttcccgg ctccgtactg gtgcgccgag gccagcgcga tgaacgcctc
    19501 catgaggcgt accggcgcct cgcgcggctt ctcgaccaac tgctcgaccg tggtggtcag
    19561 cggccggtcc agttggtcca gggccatctc ccggagatcc tggagcggct gcggccaggt
    19621 ctcgaccgag gagaagctca gcgcctcggt ggcaccgtgc tcgcgcatcg gcaggtaggg
    19681 cggtgcgacg ccttccagcc ggcccgtctc acgggcctgg gcgagatagg tctcctcgtc
    19741 cagcacggtc gcgccgtcgg cggggccggc gtcgagggcg gcggcgatcc ccgcccagtc
    19801 gagcggcggc cgcccgggca cgctccgggc gacgatgtcg acgtgcggac cgtacagcca
    19861 gccgcgtcgc aggtggagga gggcggcctg gcggtcctcg cggaggcggc ggctgaccgg
    19921 cagcacgttc cgcgccagcc agcgaggagt gatgggcacc cgggagtaca gccgtacccc
    19981 cgccgtcccg gacatctccg gaccggcggc tgctgtgtct gtgatcacgc tgcgtacccg
    20041 ttcatgatcg gaaggcgttg cgggagatgg cggccgcccg atgtggtgcg acgcggcccg
    20101 gcagggctca caatgccgcc gcgccgggcc ccggacaacg agcagtggac ggaacctgac
    20161 atctgtcatg tgccgccgga ccgcccgccg ccctgcgtcc gcggacggcg ggcggccgaa
    20221 agcccgtgaa agcggccgta ccgggcggct ccggcccctc cggaccgggc cgccgggatg
    20281 atagaacctt ggctcccgcg gacagcccgc cgaggtctcc acgcaatgga cggagcatca
    20341 ggatggttac gcagcagcgc ccttcgacgg tgtacagcac ggagcacgcc gagatctacg
    20401 atttcatcca cgcggcccgg ggccgggact ggtcggccga ggcggacggc atcacccggc
    20461 tggtccggga gcgttgtccc gcggcggatt cgctgctcga tgtcgcgtgc ggcaccggtg
    20521 cgcatctgga gcggttcgcc ggacacttcg gcaccgtggc cggcgtcgag ctctcccccg
    20581 agatgcggag gacggccacg aggagggtcc cggcggcccg cgtgcacgag ggggacatgc
    20641 gggagttcga gctcggccgg acctttgacg cggtgctctg catgtgcttc tccatggggt
    20701 acatgagcac cgtcgaggag ctgcgtcgga gcgcggcggc cctggtgcgg cacctggccc
    20761 cgggcggagt cctcgtcgcc gaaccctggt ggtttcccga gcagttcatg gacgggttca
    20821 tatcggcctc cctcgcccag gaggagggcc gcgccgtcag ccggctgtcg cactcggtcc
    20881 gggacggacg cgtcagccgg atgacggtgc gctataccgt cgcggaggcg accggtatcc
    20941 gtgagttcac cgaatacgag acgtactcgc tgttcacccg ggaggaatac ctggaagcct
    21001 tccggcaggc ggggtgcgag atggagttcc tctccgactg gccgaacggc agggggctgt
    21061 tcatcggggg ccgcccatga gggagaccac ccgcgcaacc gccccggccc ggtgacggcg
    21121 agccggggaa acccccgtcc ccccacatcg ccctgacaga tccgcgcccc gacagcaagg
    21181 cgcggaggca ggttcctgat atgtgtcaca gcccccctcg cttcgatccc acgggcccca
    21241 ggggtgggct agctttccgc ggagaatgcc gacggccctt cccggggccc cggtggatcg
    21301 accgcacatt ccggggggag accatgagcg agccgtcgga ccggatcgcc ggagtcggcg
    21361 cgcgtgccga cagcggcgtg gaggtcttcg agcgtcacta cgccggcgag ccgggcgccg
    21421 gctgggagat ccagcggccg cagacggtcc tcgtacgcct cgccgaggag ggcgcgctcc
    21481 gcggccgggt gctggacgtc ggctgcggca gcggcgacaa cgccctgctg gccgccgaac
    21541 acggcctgga gacgacgggg gtggacgccg ctcccagcgc gatcaccctc gccgtcggca
    21601 aagcgcgcga acgcggcctg aaggcgcgct tcctggaatg ggacgccctg gacctggcgg
    21661 cgctcggcga gcagttcgac acgatcatcg acgtcgggct cttccactgc ttcgcgcccg
    21721 aggaccggcc cctcgtcgcc cgcagcatgg cctccgtcgt accgcccggc ggacgctgct
    21781 tcctgatgtg cttcagcgac cggcagccgg gcgactgggg tccgcgacgc gttcccgagc
    21841 aggccgtccg ggagagtttc accggtgccg ggtggcgcgt ggacacactc gaagcagccg
    21901 aactcgacgt cgccttcagc cccggggtcg cccaggcctg gttcgccgcc atgacccgcc
    21961 tctgagcggg tcggagagaa gacgaccatg cgcgtcctgt tctgcacctg gcccgccgcg
    22021 gcccacctct accccagtgt gccgatggcc cgcgccctgc acgacgcggg ccacgaggtg
    22081 cgggtcatct cccacccctc gctgctggac accatcaacg cgacggggct gacgggggtg
    22141 tcgctcggcg acgagcagac cctgccgcag ccgctgggcg ccggccgccc catctccccg
    22201 gacacctacg ccgacctcgt ccgcatcacc aagtccctgg aactggacgg ctacgagcgg
    22261 tacgtgtgga cctactaccg ggactacatg ctgccggccg tacgcgactt ccagccggag
    22321 ggcgcccccg ccggcgaacc ccagagcgcc ctcgacgcgc tggtcggctt ctgccgctcc
    22381 tggcggcccg acctggtcct gtgggacccc acgatgccgg ccgccggtgt ggccgcccgg
    22441 gtgtccggcg cggcccacgc ccgcatcctg tggggcccgg acctgttcgg ctgggcgcac
    22501 gaacagtacg cccggtgcag gaagctctcc ggtgacgccc tcctgcccga ggacccgatg
    22561 acctcgtcgg tcaggccgat ggccgagcgc tacgggctcc ccatgaccga cgagctgctg
    22621 ttcggacagt ggacggtcaa cccggtgctg gagcggatgc gcctgcccac cgtgaagcgc
    22681 accgtgtcga tgcgctggca ggcctacacc ggcccggcgg tgctgcccga ctggctgaag
    22741 gaaccgcccg cacggccgag ggtggccatc accctcggct cctcgatccg ggcctggggg
    22801 cgggacagcg ccctgctcgt caaccgcgta ctggagatgg tggacggact ggacatcgag
    22861 gccgtcgcca cgctggacgc ctcccagctc gcggtggccg accggatacc cgacaacgtc
    22921 cggaccgtcg actacctccc gctgaccgaa ctgctgccga cctgttcggc ggtgatccac
    22981 cacggcggcc acggctcgtt cggcgccgcc ctggtcaacc ggatcccgca gttcgtcgtg
    23041 atggaccccg gctaccccat ggaggcgccg atcacgggcc ggttcctctc cgagagcggt
    23101 gtgggtacgg gggtgcgcgt cgaccggcac accggcgccg aactgcgcgc cgggctgtcc
    23161 cgcctgctca ccgcgccgtc cttccgcgac gccgcggcgg agctgtacac ggacctgctg
    23221 accgctccgg agccgagcga gatcatcccc gtcctggagc gcctcacccg acaccaccag
    23281 agccgggact gaacccgccc ccttcccatc gtccccaccc gcgccaggga gccaccgcgt
    23341 gatcaacgtc ttccagccga acctgggcga ggcggaactc ctcgccctgt ccgaggtctt
    23401 cgcatcgaac tggctgggcc acggaccccg caccgacgag ttcgaagcac gcttcgcgga
    23461 ccacatcggg gtcgagccgg accggatggt cttcctcaac tccggtacgg ccgggctctt
    23521 cctcgccacc gagctgctcg atctgggccc cggcgacgag gtggtgctgc cgtccgtgag
    23581 cttcgtggcc gccgccaacg ccatcgccgc gaccggggcg cgccccgtct tctgcgacgt
    23641 cgacccccgt ggtctccacc cgaccgtgga gcacatcgag cgtgccatga cgccccgtac
    23701 cagggccgtc atcgtgctgc actacggcgg ctaccccggg gaggtcgagg ggatcacggc
    23761 cctgtgccgg cagcgggggg tccccctcgt cgaggacacg gcctgcgccg tggcctccac
    23821 ggtcgacggc agggcgtgcg gcaccttcgg cgatatcgcc ctctggagct tcgacgcgat
    23881 gaaagtgctg gtcaccggtg acggcggcat gctgtacgtc cgcgatccgc agctcgcgcg
    23941 ccgcgcccgg gtcctcgcct accacggtct ggagcagccc agcggcttcg cccacgcgaa
    24001 ggtgtccgag cggtggtggg agctcgacgt acggaacttc ggccgccgcg tcataggcaa
    24061 cgacctgacc gccgcgctcg gcacggtgca gctcgcccgg ctgcccgcca acgtcgcccg
    24121 gcggcgcgag gtggcgaccg cctacgacac cctgctcgcg aacacccccg gcgtacgcct
    24181 gccgcccccg ctgcccgagg gccaccgctc ctcgtactac ttctactggg tccagatgga
    24241 tccgctgatc cgtgaccggg tcgcggccac gctgctggcc caggacatct acaccacctt
    24301 caagtacccg ccgctgcacc gggtgcccgc ctacggcgac cgggccaccc acctgcccgg
    24361 gaccgacctg gccaccgaca gcacactcct gctccccctc caccaggcgc tgagcgacgc
    24421 ggatatccgg acggtggcga acgcgctgtg cgaagccgtc acccaccacc tggccctggc
    24481 cggggcctga ccgctcgacg ggaggaacgc ccatgaaggc gctgatactc gccggggggc
    24541 tcgggacgcg gctgcggccg ttcaccgaga ccatgcccaa acagctgata cccatcgcca
    24601 accagcccgt gctcgaacac gtgctggaga acctgcgcgc gctgggcgtg cgggagatct
    24661 gcgtggtcgt cggcgcgtgg gggcccgaca tcgcggcacg gatcggcgac gggtcgcggt
    24721 tcggcgcccg gatcacctac ctcacgcagc agcggccgct ggggctggcg cactgcgtgg
    24781 ccatcgcccg tccgttcctc ggcgacgacg acttcgtgat gtacctcggc gacaacgtcg
    24841 tacaggacgg catagcggag ccggcaaagg agttccgggc ccgccggtcc gacgcgcaca
    24901 tggtggtggc cagggtcgcc gacccccgcg ccttcggggt ggccgagctg gacggactcg
    24961 gccgggtccg acggctggtg gagaagccgc gtctgccgct cagcgacctg gcgctcatcg
    25021 gcgtctactt cttccgcccc gccatccacc gggcggtcgc cgcgatcggc cccagcgcac
    25081 gcggcgagct ggagatcacc gacgccgtcc agtggctggt cgaccgcgga agccaggtca
    25141 cggccggcga gtacaccggc tactggaagg acaccggacg cgtggaggac gtgctggact
    25201 gcaaccggcg cctgctggac agcctggccc ggggcgtcca cggaacggtc gacgccgcca
    25261 gccgcctgac cggcccggtg cacatcgccc cgggcgccac cgtgctgcgc tccgtcatca
    25321 ccgggccggt gatcgtcggc cccggctccc gcgtcgagga ctgccggatc ggaccgggca
    25381 catcgatcgg cggggactgc gtcctgcgcg gcaccgagct ggagaactcc atcgtgatgg
    25441 acggcgcgtg ggtgacggaa cggaccggtg cgagcgacct gctcatcggc cgctcgatgc
    25501 ggatcggctc cggctcgccc ccggtgccac cgcccgcgga actggctgcg aacggcgcgc
    25561 gtacaggagg aacccgatga ggattctggt caccggcggg gccgggttcg tcggctcgca
    25621 ctacgtacgg acgatgctgg cgcaggggta cccgggctac gagcgggccg acgtcaccgt
    25681 gctggacaag ctgagctacg cgggcaacgc cgagaacatt ccgatcggcc acccccggct
    25741 gcgtctcgtc aagggcgaca tctgcgacgc cccgctgctg aacgaactgc tgcccggcca
    25801 cgacgccgtg gtgcacttcg cggccgagtc gcacgtcgac aggtccctgg acgcccccgc
    25861 cgtcttcacc cggacgaacg tggtgggcac ccagaccctg ctggacgcct gcctggccgc
    25921 ccgggtggag cgggtggtgc acatctccac ggacgaggtg tacggcagca tcgacgaggg
    25981 ctcctggcac gaggagtcgc cactgctgcc caactcgccc tacgcggcct ccaaggcggc
    26041 ggcggacctg accgtacgcg cctactggcg caccttcggg ctcgatgtgt cgatcacgcg
    26101 gtgctccaac acgtacggcc cgtaccagca cccggagaag gccatcccgc gcttcaccac
    26161 caacctcctg gagggcgagc cgatcccgct gtacggctca gggcggaacg tacgcgactg
    26221 gatccatgtg gacgaccacg cgcgggccgt ccagctcgtg ctgaccaagg gagtcgcggg
    26281 cggcgtctac cacgtgggcg gcggccacga gctgaccaac atcgagctgg cggagcagct
    26341 gatcgccctg tgcggcgcgg accggtccat gatccggcat gtgaccgacc gcaaggggca
    26401 cgacctgcgc tactcgctgg acgggtccaa ggcccgtacc gagctggggt tcacgccgcg
    26461 ggtcggcttc gccgagggac tggccgccac cgtcgactgg taccgggaga acacggcgtg
    26521 gtggaaggcc gcgaaggccc aggcagcgga cacggaggac cggtcgtgaa cgacgagcac
    26581 aggacgcggg tcctggaaga gacgcggaag caccaccaga gcgtgcgtga ttccggggag
    26641 ttcgtgccgg gcaccacgga gatctggccg tcgggcgccg tcctggacga ggacgaccgc
    26701 gcggcgctgg tggaggccgc cctggatctg cggatcgccg ccgggccgct ctccaagcgc
    26761 ttcgagtcgg acttcgcgcg gctgctgaag cgccgcaagg cccatctgac gaactccggt
    26821 tcgtcggcca acctgctggc gctcaccgcc tacacctccc cgcagctggg cgaacggcgg
    26881 ctgctgccgg gcgacgaggt catcacggtc gccgcggggt ttcccaccac ggtgaacccg
    26941 atcctgcaga acgggctggt gccggtcttc gtcgacatcg agctcggcac gtacaacacc
    27001 accgccgacc gggtcgccgc ggccatcggg cccaggaccc gcggcatcat gatcgcgcac
    27061 gccctcggca acccgttcga ggtggcggag atcgcccaac tcgccgcgga ccacggcctg
    27121 gtgttcgtcg aggacaactg cgacgcggtc ggcaccacct accaggggcg gctgaccggg
    27181 acgttcggcg acatcagcac cgtgagcttc tatcccgccc accatctgac gatgggcgag
    27241 ggcggcatcg tgacgacctc ggacctcaag gtcgcgcgga tcgtcgaatc actgcgggac
    27301 tgggggcggg actgctggtg cgaaccgggc cacagcgaca cctgcctgaa gcgcttcgac
    27361 caccagctcg gcgcgttgcc cgcaggctac gaccacaagt acatcttctc ccacgtcggt
    27421 tacaacctga agtcgacgga cctgcaggcg gcgctcggcc tgtcacagct gcggaagctg
    27481 gacgggttca tcgcggcgcg ccgccacaac tggcggcgga tgcgtgaggg cctggacggc
    27541 gtacgccacc tcctgctgcc ggaggcgact gccggcagcg acccgagctg gttcggattc
    27601 gtgatgacgg tggggcccga cgccccgttc acatgcgggg agctgaccgg gttcctggag
    27661 cagcggaaga tcggcacgcg ccgcctgttc tcgggcaacc tcacccgtca gcccgcctat
    27721 caccagcagc cccaccgcgt cgtcggcgaa ctgaccaaca gtgacatcgt cacggagcgc
    27781 acgttctgga ccggggtcta tccgggcctc accgacgaga tgaccgacta cgtcatcgcc
    27841 tcggtgcggg agttcgtggc aggccgtcgg tgagagtcga cagcccccgg tcgcacggca
    27901 cggcgaccgg accgagcgag ccgagcgggc cgagtaagcc ggacgggcag ggcgagccga
    27961 gcgggctggg cgggccggac gggcagcgcg ggctggcggc caggatcgcc cgctccgcgg
    28021 ccgccaccgg cccggccacc ggagcccgga ccacgacgga cgagatcctc gcgtggctgg
    28081 cggaacgccg cagggcccac ggcacacgga tccggcgcat cccgttcgcg gagctggacg
    28141 gctggtcgtt ccaggaggac accgggaacc tggtccaccg cagcggccgc ttcttcaccg
    28201 tcgagggcat gcgtgtgcac gacgcggacc ggcccggcgc tccgtgggag cagcccgtca
    28261 tgaggcagcc ggaggtcggc gtactcggcc tgctcgccaa ggagttcgac ggcgtactcc
    28321 acttcctggc ccaggccaag atggaaccgg gcaaccgggg catgctccag ctgtccccga
    28381 ccgtgcaggc cacccgcagc aactaccagc gggtgcacgg cggctcgggc gtgcggttcc
    28441 tggagttctt caccgagccc ggccgcgccc ggcccctgac cgacatactg cagtccgagc
    28501 acggcgagtg gttcctgcac aagtcgaacc gcaacatcgt ggtggagacg gccgacgagg
    28561 tcgccgagga ccccgccgcc gaaccggact tccgctggct gaccctgggc cagatcggcg
    28621 agctgctgcg gctggacaac gtggtcaaca tggacaccag aaccgtgctg gcctgtctgc
    28681 cgaccgccgg agagcagcgg ccgtcccggc acaccgacgc cgaggtgtcc acctggctcg
    28741 gcgccgcccg ctcccgctcc cggctccggg ccgagcccgt gccgctcgcc cgggtgcggg
    28801 gctggctccg ggacgagcgg gccgtccgcc gcaccgacga cggccacttc cgcgtggtcg
    28861 cggtcgcggt cgaggcggac ggccgg
//
