LOCUS       NZ_KZ195572            22631 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS057 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195572
VERSION     NZ_KZ195572.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS057
  ORGANISM  Streptomyces sp. CS057
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 265.32x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188345.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:40:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,152
            CDSs (total)                      :: 7,074
            Genes (coding)                    :: 6,991
            CDSs (with protein)               :: 6,991
            Genes (RNA)                       :: 78
            rRNAs                             :: 10, 6 (16S, 23S)
            complete rRNAs                    :: 10, 6 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 23 of 83
            Pseudo Genes (incomplete)         :: 71 of 83
            Pseudo Genes (internal stop)      :: 4 of 83
            Pseudo Genes (multiple problems)  :: 14 of 83
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:25:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2894155
            Orig. end                         :: 2916786
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..22631
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="20"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22631
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22631
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12631](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12631)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    541..555
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.11"
                     /tool="antismash"
     misc_feature    complement(602..617)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.37"
                     /tool="antismash"
     gene            727..1194
                     /locus_tag="B9W61_RS11900"
                     /old_locus_tag="B9W61_11880"
     CDS             727..1194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674798.1"
                     /locus_tag="B9W61_RS11900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11880"
                     /product="ATP-binding protein"
                     /protein_id="WP_087765059.1"
                     /transl_table=11
                     /translation="MSLPLTRRIARAALLIAAGAAPVVGAAGAASAADLPATPDLGGLT
                     ALDGAGLGNTADSAVQQGTQAAGDTGGRLVGTALPAAGKTVGKSAGVAVPAAQETAGEA
                     AGNAGQAVGGVAEAAGGGLPTDALAGGLPTDALGGGLPTDSLTKGGLPLGG"
     gene            complement(1290..2384)
                     /gene="dapC"
                     /locus_tag="B9W61_RS11905"
                     /old_locus_tag="B9W61_11885"
     CDS             complement(1290..2384)
                     /EC_number="2.6.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (29-363). E-value:
                     4.7e-45. Score: 146.2. Matches aSDomain:
                     nrpspksdomains_B9W61_RS11905_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="dapC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984558.1"
                     /locus_tag="B9W61_RS11905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11885"
                     /product="succinyldiaminopimelate transaminase"
                     /protein_id="WP_087765060.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.3e-43, bitscore:
                     146.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVSSRLPVFPWDKLAPYKSTAQAHPDGIVDLSVGTPVDPVPEI
                     VQRALVAAADSPGYPTVWGTEALRDALTGWVERRLGAVGATHANVLPVVGSKELVAWLP
                     TQLGLGAGDKVAYPRLAYPTYEVGARLCGAEPVVYDDPTELDPTGLKLLWLNSPSNPTG
                     KVLSKDELTRIVAWAREHGVLVFSDECYLELGWDAEPVSVLHPDVCGGHYDGVVAVHSL
                     SKRSNLAGYRAAFIAGDAAVLGELLLIRKHGGMMTPAPVQAAAVAALGDDVHVSEQRAR
                     YADRRLALRAALEAHGFRIEHSEASLYLWATRDEPCWDTVAYLAQLGILVAPGDFYGPA
                     GARFVRVAFTATDERVAAAVKRLS"
     aSDomain        complement(1296..2297)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9W61_RS11905_Aminotran_1_2.1"
                     /evalue="4.70E-45"
                     /label="B9W61_RS11905_Aminotran_1_2.1"
                     /locus_tag="B9W61_RS11905"
                     /protein_end="363"
                     /protein_start="29"
                     /score="146.2"
                     /tool="antismash"
                     /translation="IVDLSVGTPVDPVPEIVQRALVAAADSPGYPTVWGTEALRDALTG
                     WVERRLGAVGATHANVLPVVGSKELVAWLPTQLGLGAGDKVAYPRLAYPTYEVGARLCG
                     AEPVVYDDPTELDPTGLKLLWLNSPSNPTGKVLSKDELTRIVAWAREHGVLVFSDECYL
                     ELGWDAEPVSVLHPDVCGGHYDGVVAVHSLSKRSNLAGYRAAFIAGDAAVLGELLLIRK
                     HGGMMTPAPVQAAAVAALGDDVHVSEQRARYADRRLALRAALEAHGFRIEHSEASLYLW
                     ATRDEPCWDTVAYLAQLGILVAPGDFYGPAGARFVRVAFTATDERVAAAVKRL"
     gene            complement(2581..2901)
                     /gene="fdxA"
                     /locus_tag="B9W61_RS11910"
                     /old_locus_tag="B9W61_11890"
     CDS             complement(2581..2901)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950253.1"
                     /locus_tag="B9W61_RS11910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11890"
                     /product="ferredoxin"
                     /protein_id="WP_007446848.1"
                     /transl_table=11
                     /translation="MTYVIAQPCVDVKDKACIEECPVDCIYEGQRSLYIHPDECVDCGA
                     CEPVCPVEAIFYEDDTPEEWKDYYKANVEFFDDLGSPGGASKLGLIERDHAFIAGLPPQ
                     NQ"
     gene            3019..4074
                     /locus_tag="B9W61_RS11915"
                     /old_locus_tag="B9W61_11895"
     CDS             3019..4074
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061638.1"
                     /locus_tag="B9W61_RS11915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11895"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_087765061.1"
                     /transl_table=11
                     /translation="MEFTIGGRLEVRITPADVGKRVSVRRRTDNGGPGAEFTDVVGVLT
                     SWNNGVLSITRKSGESVHIVESSLAAGKVVPAAPARRRGPAASFGELAAVTARAWQPVE
                     SEALGDWRLRAAGGFTRRANSALPLGDPGLPVGEALGRVRDWYEERGLPAYVQTATGAE
                     GTQELLCAELERHGWRREVSAEVRIAALAPVGDLEADVRAVRLTREPDATWLARYQRFS
                     TPGPHVLRVLGSGPSVWFATVPGAAEATEATGDAADAGGRDAGPDAPPAAIGRCVVDGR
                     WAGFMAVEVAPEHRRRGLATTVMAALARRALDEGASAAWLQVEEDNEGARALYDGMGFA
                     AHHRYHHYRSA"
     gene            4151..5032
                     /locus_tag="B9W61_RS11920"
                     /old_locus_tag="B9W61_11900"
     CDS             4151..5032
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956285.1"
                     /locus_tag="B9W61_RS11920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11900"
                     /product="transglutaminase-like domain-containing protein"
                     /protein_id="WP_047178635.1"
                     /transl_table=11
                     /translation="MSALDSGTAERRRQFAEEARSERPDLALLCLLLGAEAGPVGPTEV
                     RPVTPGEAVPDPYGIDAAQIELDRLAGLLPYGSRSPAAWASALAELLGGRCGFGGSSVD
                     YQRLDSSLLQQVLRRRRGLPILLSVVWIEVARRAGAPVYGVALPGHFVVGFGDREHPVL
                     ADPFAGGAPLTGQDAELLVTGATGAALEPSMMTPARPLEIVLRILNNVRAWAAARPERT
                     DVALWAVELSLLLPSHPARLRFERAQLLVQRGEFLRGAAEMEEYAEILDGIEPTTAENI
                     RRKAHAARALLN"
     misc_feature    5203..5216
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.91"
                     /tool="antismash"
     misc_feature    complement(5211..5228)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            5303..5908
                     /locus_tag="B9W61_RS11925"
                     /old_locus_tag="B9W61_11905"
     CDS             5303..5908
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127364.1"
                     /locus_tag="B9W61_RS11925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11905"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_047178634.1"
                     /transl_table=11
                     /translation="MTTVLLVHTVPLWRASLASLLGTGRGIEVRTAEHGAIRAALNGPC
                     PDVLLTDLECPGALDVLDEVKTVTAPHGGPCPLAVLTRSDRPSGLRRAFEAGALGYIDK
                     YRPVDDLSEVMHKLADGGRHIDESLAFSLLQVADMPLSPRELSVLSMAEGGDTVAGIAG
                     RLHLTPGTVRNYLAAAIRKSGARNRLDAIRRAKEAGWI"
     misc_feature    5723..5725
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5877..7727)
                     /locus_tag="B9W61_RS11930"
                     /old_locus_tag="B9W61_11910"
     CDS             complement(5877..7727)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061641.1"
                     /locus_tag="B9W61_RS11930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11910"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087767803.1"
                     /transl_table=11
                     /translation="MRRVGREARPFLRARTGAVLRLGGWSLLEFAQTFLGGFGVARALD
                     DGFLAGRPSTGLLWLAVAAAAVLPSVPAARGVFGRLADLVEPLRDGLVRRAVSRALSGA
                     LDRSGDVSTRSLSQVTHQSEIARDGWAGLVLTLRSFVFTVAGAVTGLLALSPALLLIVL
                     PPLVLGSALFLGTLPPMAARQRDYLAADEAYAAHAGRLAASVRDIAAAGAAERTVAESR
                     TLAEEQLAASRSLARWSGVRVLALAVCGRFPPLLLLLGAPWLLRNGLTPGALVGALTYL
                     TQALAPAVQALMTMLGTAGGRLVVVLDRFTDAPPPPAEDPPPSRDTAPPPRGTPVAELH
                     EVSFAYGPGAHPVLDRLSLTVGAGEHLAVVGPSGSGKSTLAAVLAGTERPTGGAVRWRG
                     RPVRPADATSVRVLLPQHAYVFSGSLRDNLRYLRPDARDREIAAMADAIGLEALLSRLG
                     SLDAAVEPDRLSQGERQLVALGRAFLAAPPLLILDEATSRLDPAAETRAELALGALPGA
                     LVVVAHRLSSARRAGRILVMDGPRTQCGTPDELLRSCALYRDLAGLWEPETTGEPGTAG
                     EPEGPGEQDGPGEPEGPGGAVGTGRGQARGIRSTPPPSPV"
     gene            complement(7976..9745)
                     /locus_tag="B9W61_RS11935"
                     /old_locus_tag="B9W61_11915"
     CDS             complement(7976..9745)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446857.1"
                     /locus_tag="B9W61_RS11935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11915"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087765062.1"
                     /transl_table=11
                     /translation="MRLYPRPGAESGTRRLARQHPAALLGLLLCSTGGALAALALPAAL
                     GHTVDRLVAGGPVPWSWLLLCAALTLTETGFDAAAAVTGTSTTARLTASLRTRTAARVL
                     AAEPRRALALPTGDLTARLTARTADAASAPVTAAGAVAGVLLPLGALVGLLLVDVWTAA
                     ALLLGAPLLVALLRAFTRRTADAGADYQRAQSLIAHRLTEALDGADTIRAARTGAREHR
                     RVLEPLNALAEHGRRTWAVYGRAVGRSGLLLPLLMLLVLAVAGLRLGTGAIGVGDLVAA
                     SRYASLAVGIGALTGALGALARSRAAARSLDPLLTLAPLPHRGLGPVPDAPGHLELRDV
                     GVEQDGGPLLTGVHLTVPGGTSLAVVGRSGSGKSVLAAVAGRLLDPDTGSVLLDGVPMD
                     GMEPARLRREVAYAFARPALTGTTVEDTIAYGPWTASPEAVRDAARAARADKFLALLPY
                     GYATPLVDAPLSGGERQRLGLARAFAHPGRLMILDDALSSLDTVTEHHVRRALDERAGH
                     CTRVIVAHRLSSAARADRVAWLEDGRIRATGRHDELWADPDYRAVFRTDVPAEGSVPAS
                     RTPVAPAAGAEAR"
     gene            complement(9825..9956)
                     /locus_tag="B9W61_RS11940"
                     /old_locus_tag="B9W61_11920"
     CDS             complement(9825..9956)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="B9W61_RS11940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11920"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_003966507.1"
                     /transl_table=11
                     /translation="MALLDLQAMDTPAEDSFGELATGSQVSLLVCEYSSLSVVLCTP"
     CDS_motif       complement(9891..9956)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQAMDTPAEDSFGELAT"
                     /locus_tag="B9W61_RS11940_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9825..9890)
                     /prepeptide="core"
                     /locus_tag="B9W61_RS11940_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="31.80"
                     /molecular_weight="2076.4"
                     /monoisotopic_mass="2075.1"
                     /core_sequence="GSQVSLLVCEYSSLSVVLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQAMDTPAEDSFGELAT"
                     /leader_location="[9890:9956](-)"
                     /alternative_weights="2094.4"
                     /alternative_weights="2112.4"
                     /alternative_weights="2130.5"
                     /alternative_weights="2148.5"
     gene            complement(10001..12631)
                     /gene="lanKC"
                     /locus_tag="B9W61_RS11945"
                     /old_locus_tag="B9W61_11925"
     CDS             complement(10001..12631)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446862.1"
                     /locus_tag="B9W61_RS11945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11925"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_087765063.1"
                     /sec_met_domain="micKC (E-value: 1.5e-233, bitscore: 776.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.8e-11, bitscore: 42.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.4e-07, bitscore:
                     28.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYAAYCQADRRFYDAPHRSPGPGGAANEERSFYAPLRGAVPD
                     GWTRSRRGDWLAYSPDGLRLPPQGWKIHVSAALDNAASVLERVVAHCLEHRLAFKCVPN
                     AGLLGLRNAKYADRAGSGKFITVYPPSDEAFPEVCTALMQLLEGEHGPYILSDLRCGNG
                     PVHTRYGAFAARFCSGPDGRPVPAVADPQGRLVPDDRGPSFRVPSWVTPPGFLMPHLEA
                     RAAVGLADLPYTVEKALHFSNGGGVYLGRDTRTGEQVVLKEARPYAGLAADGADAVARL
                     ERERTALEQLAGLDCVPAVRDVFEVGDHHFLVLQYIPGTTLNTVFARRFPLARQHPSPE
                     LLAEHAAWASELYGQVERAVEAVHGRGIVISDLHMSNVMVDEENARIVLLDFEAASPAA
                     EHRRQIVANPAFVAPPDRRGADIDRYALACLRLALYLPLTTLFGIDRTKAAGLARDIAR
                     VFPVTEETLRPAVAEILRDTGRPGAGATAAPALLPDPGDWPRSRDALARAITASCTPER
                     EDRCFPGDIAQFATATGGQSFAYGAAGVLYALHATGAPPCEEAEDWLLRHAKDPASGSP
                     LGFYDGLTGIAWTLHRIGRTAEAADLLRIILDQPLQGLAPGLHNGYAGIGLALDDLARS
                     ASATDAPALSAAAARCTALAVRALVDGPPSPRTGLLHGASGIALLLVRRYATTGDAALL
                     DLAATALHRDLERCRAGDDGELLVVEGKRLMPYLGAGSAGIAAVIDAYLAHRPDPALEA
                     AGRALLPAALSAFYVQPGLLRGSAGLLMHLAATPLCDEADRQRAIARHTDLLGSHALAY
                     GDGLAFPGEQLMRLSMDLATGTAGALLALGAALGGSTGLPFLPAAPAAHPGRASGPTDR
                     PHQGS"
     misc_feature    12667..12679
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    complement(12670..12690)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.1"
                     /tool="antismash"
     gene            complement(12841..13818)
                     /locus_tag="B9W61_RS11950"
                     /old_locus_tag="B9W61_11930"
     CDS             complement(12841..13818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611151.1"
                     /locus_tag="B9W61_RS11950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11930"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_087765064.1"
                     /transl_table=11
                     /translation="MGWWQVGADTLASSRFVVSPLAEAVASLLVLERATAAHPGERAWL
                     ETHLPAYRRWKADDPVSALVIGAALAPRWIADFLIPVPDPAPPGQAPPSFADELTPVRA
                     TPPDRARAELAEAVRGPLPAALDRDDLALRAADALEWVWTHTVLPDWPRRRRILEADVI
                     ARSAQLGRGGWVDALNGMRPGIRWLGDSRLQINTHDNPPRELDGAQLLFVPVTPYQSWV
                     CWDIPRRYGLVYPCSGALADAARIPVPAALGALIGPARAAVLLLLASPLSTTQLVALTG
                     QGLGSVGRHLRILLEAGLVRRRRAGRSVLYFRTEAGDVLVHGAG"
     gene            14008..15246
                     /locus_tag="B9W61_RS11955"
                     /old_locus_tag="B9W61_11935"
     CDS             14008..15246
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127359.1"
                     /locus_tag="B9W61_RS11955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11935"
                     /product="MFS transporter"
                     /protein_id="WP_087765065.1"
                     /transl_table=11
                     /translation="MRTYRELFRTPEFTPFFATVSVQTAAQTATGLALGTLVYTRTGSP
                     LLSALAMFGPSLAQVAGALTLLSAADRLPPRAALTALALLSAGAACVQAVPGLPLWAAF
                     TVLLAWGAASSPGGGVRYGLLNEIVPREGFLIGRSVLNMTGGAMQICGFAVGGLLVAVF
                     SARGTLLIGAGLYVVAAAVTRFGLTARPPRATGRPSVRETRRTNALLWSSTPRRYVFLA
                     LWVPNGLVVGAESLYVAYAPGHAGLLFAGGAVGMLAGDTLVGRFVAVRWRARLGAPLRL
                     LLAAPYLLFALRPGLPLALALVVVASVGFAASLLLQERLMALTPQELSGQALGLSSSGM
                     LAMQGVGAAVAGGIAQLTSPATGMAAVAGLSVAVTLALAPGLRDRSGGVGGRLPGADGS
                     PRASRTPHTEETT"
     gene            15243..15827
                     /locus_tag="B9W61_RS11960"
                     /old_locus_tag="B9W61_11940"
     CDS             15243..15827
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956278.1"
                     /locus_tag="B9W61_RS11960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11940"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_087765066.1"
                     /sec_met_domain="Mac (E-value: 7.4e-15, bitscore: 53.6,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNARPSQKEAMLSGELYIADDPELAADAQHAAVLSERFNATSA
                     ADPEARRAALAELLGELGEGVEVRPPLRVDYGYRTTIGPRTFINFGAVLLDVARITIGA
                     DVQMGPNVQLLTPTHPIDPEPRRAKWEAARPITIGDNVWLGGGVIVCPGVTIGENTVVG
                     AGAVVTKDLPANVVAVGNPARVIRTIGEPEA"
     gene            complement(15943..16446)
                     /locus_tag="B9W61_RS11965"
                     /old_locus_tag="B9W61_11945"
     CDS             complement(15943..16446)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446870.1"
                     /locus_tag="B9W61_RS11965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11945"
                     /product="DUF4265 domain-containing protein"
                     /protein_id="WP_050360583.1"
                     /transl_table=11
                     /translation="MSSPAGPERPPREADQIKVWFRFVPREGWLPYDTEGLWATRLGPD
                     TARVDNVPFLQDGVAEGETVRFRTDDEGVHWAVGRVADSGNCTVRVLPLPDGPLGRDAR
                     AVHERLAVFGLTGEVFSAEFPLVALTVPGGADLRGVKALLARGRDEGWWHFEVSCVTDA
                     WRAA"
     misc_feature    complement(16644..16661)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.51"
                     /tool="antismash"
     gene            16745..18520
                     /locus_tag="B9W61_RS11970"
                     /old_locus_tag="B9W61_11950"
     CDS             16745..18520
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379170.1"
                     /locus_tag="B9W61_RS11970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11950"
                     /product="coagulation factor 5/8 type domain-containing
                     protein"
                     /protein_id="WP_087765067.1"
                     /transl_table=11
                     /translation="MHAPPTAPRTRRRTRALGFAALAVAMLMSVPTAQTAFGEEVRAVP
                     GGGDLGPNVHVFDPSTPDIQGKVDEIFKKQESAQFGTDRYALMFKPGTYDEINAQIGFY
                     TQIAGLGLNPNDTTFNGDVTVDAGWFDGNATQNFWRSAENLTLNPVNGTNRWAVSQAAP
                     FRRMHVKGGLNLAPDGYGWASGGYIADSKIDGTVGPYSQQQWYTRDSSVGGWGNGVWNM
                     TFSGVEGAPANSFPEPPYTTLDTTPISREKPFLYLDGDAYKVFVPEKRENARGISWGNG
                     TPAGESIPLDRFYVVKEGADAATINAAVEQGLHLLFTPGVYHIDETITIDRADTVALGL
                     GLATIIPDNGVTAIKVGDVDGVKLAGLLVDAGPVNSETLIEVGPENASADHSANPTSLQ
                     DVFVRIGGAGPGKATTSIVVNSDDTIIDHTWVWRADHGEGWGWETNRADYGVRVNGDDV
                     LATGLFVEHFNKYDVEWYGERGRTIFFQNEKAYDAPNQEAIQNGDTKGYAAYRVDDSVE
                     QHEGWGMGSYCYYNVDPTIIQEHGFKAPVKPGVKFHSLIVVSLGGNGQYEHVINDVGSP
                     TSGPDTIPSQVVNFP"
     gene            complement(18600..19976)
                     /locus_tag="B9W61_RS11975"
                     /old_locus_tag="B9W61_11955"
     CDS             complement(18600..19976)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455451.1"
                     /locus_tag="B9W61_RS11975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11955"
                     /product="alpha-amylase family protein"
                     /protein_id="WP_087765068.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.6e-23, bitscore:
                     80.7, seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase_C (E-value: 3.3e-12,
                     bitscore: 45.3, seeds: 246, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRAARATLAGLLAAGGLTVLAPWPSQATPPGEKTVTATLFEWK
                     YDAVATACTDTLGPAGYGYVEVSPATEHIQGDQWWTSYQPVSYRIAGRLGDRDSFAAMV
                     ESCHSAGVKVVADAVINHMAAGSGTGTGGTSYTKYDYPGTFRDQDFHTCRKDIANYGDR
                     GDVQNCELVGLADLDTGSDTVRTTIAAYLSDLRSLGVDGFRIDAAKHMSADDVAAIKGK
                     MGDPGFWVTEVIHGGGEAVQPEEYTSIGDVDEFRYGGHLKSAFQGGGLPGLKSIADGKL
                     AGASARTFVDNWDTERNGSTLTHKDGAAYTLANVFMLASPYGSPNVFSGYTWTDKDAGP
                     PNGGAADCGSGAWTCTHAQQAVTGMVGFHNAVAGAELTDWWDDGSSALAFARAGKGFVA
                     VNNGDAELNRTFTTTLPAGTYCNVVTSAPDSCDGDGTTVAEDGTATITVPARGAVALHT
                     "
     misc_feature    complement(20115..20128)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.69"
                     /tool="antismash"
     misc_feature    20115..20129
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.57"
                     /tool="antismash"
     gene            complement(20328..22517)
                     /locus_tag="B9W61_RS11980"
                     /old_locus_tag="B9W61_11960"
     CDS             complement(20328..22517)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966514.1"
                     /locus_tag="B9W61_RS11980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_11960"
                     /product="hypothetical protein"
                     /protein_id="WP_179233751.1"
                     /transl_table=11
                     /translation="MSRETDSSSSGPQGRGGAAYPSGTPPYGSRQYPSLHPSQDGSDEN
                     PESVAPPRPEEPKTETTLTTRIRINIPGSRPIPPVVMRTPMAESDISGGRSDAERTGAT
                     PRPGTPPPAPGAGSSDRAAGPNGAAPADRPGDGGPAADPTPAEKPGREKSGSDWFAPRK
                     TPATGPGTAAQGAGAPGASGGGAPSGSGGAQGPGTGGPGGPGGPSADGSAGPGGGADGD
                     AGRSRPDLPYFSDAPQSGGGPGTPGPGRSALDGYGTEPPGGGPRSTPGLGVRPPGPSGP
                     SGPTTGPVTGSSSLTPNLDGVPGLGGPGPMVPGVPGAVPPRMSDDTAILTPQAPAPEPG
                     SGHVSGDTLTSGIPVVPSEPRAAFPGGPGISGIPGGPAAGGPQGGPGGPGGPGVPAPGP
                     AAPRPASQATAAPAKKGRSKLVLLGVAAVVLVGIAYGAGLLLNHSEVPKGTTVLGVDIG
                     GGTKEEAVTKLEAALGERAKTPLTLSVDGKEEKLDPEKAGLTLDSQETVRGAAGSDYNP
                     VSVIGSLFGGERPADPVIPVDEEKLGVALTDLAGVSGSSNDGTIRFEPNKAVAVPGKPG
                     KTLDAGQSLISVRDAYRAQVQTGQARLVELPVTTSEPTITKTELDRAMKEFAEPAMSGL
                     ITIKAGPKQIQFGPARSLPQILSMKPVDGRLVDVYDKQAIDKLLDGVFDGIMAVKGDGK
                     KHQVGADDVAQAMKTALAGKTPAERTVTIDLTGQG"
ORIGIN
        1 gttcccgcag gcgtacgcga agcacgagcc ggacgccgcg ctgctggccg ccgcgctgac
       61 cgggcgcagg ccggccgcgc tgaactgcac cccgtcgacg gccacggcgg acggtccggg
      121 cgactccgcc caggtgcggg ccgagctggt gcgggccttc ggcaagggcg tgctgcccga
      181 cgcggtggcc gcgggcgcgt ccgccgcgtc gaccgtctcg gtgcccgttc cggcgaccgc
      241 ggcgcggtcg gagagcaggg ccgcgcagcg cggctgggag ctggcgcact gggccgtggc
      301 gcagtccgag gccctgcgga tcgagcgcgt gagctacgcg gaccgggtct gggacgccgg
      361 ttcgggctgg cggacggaac gcgcgaagga tgaggaaacg ggcacgacgg cggtcaggat
      421 ccaggtcgtt cagtagtaca ccccgtcacc cgtacgggcc ccgggggctc tgcccccgga
      481 tgttttccgc gcgacttctc gcagcttcgc gagcccgccc cgatcccctt gccgcccaag
      541 ggaagtgacg gttcaccgca ccacggcggt atggattgtt tgcccgggtt cttccactgc
      601 ggataatcgg acgcattact cagtctttac ctttgcccac cgcaacctcc ccctcccccg
      661 aagcggttgt cagtgcgtcc gatcaccgga cagacagatt cgtgcacaac ccgctgaagg
      721 agcatcatgt ccctccccct gacccgtcgg atcgctcgtg ccgcgctgct gatcgccgca
      781 ggcgcagccc ccgtggtcgg tgcggccggc gccgcgagcg ccgcagatct cccggcgacc
      841 ccggacctcg gcgggctgac cgcgctggac ggcgccggtc tcggcaacac cgcggacagc
      901 gccgtgcagc agggcaccca ggcggccggc gacaccggcg gccggctcgt cggcacggcg
      961 ctcccggccg cgggcaagac cgtcggcaag tccgccgggg tggccgtccc ggccgcccag
     1021 gagaccgccg gcgaggccgc gggcaacgcg ggccaggccg tgggcggcgt ggccgaggcg
     1081 gccggcggcg gcctgccgac cgacgcgctc gccggcggtc tccccaccga cgcactcggc
     1141 ggtggcctgc ccaccgactc cctgaccaag ggcggcctgc cgctgggcgg gtgatccacc
     1201 gcagtaccga ccgacgcgcc gagggcctcg ggagtgcgca ctcccgaggc cctcggcgcg
     1261 tcatgtcgcc gtcatggcgg cggcgccggt caggacaggc gcttgaccgc cgcggccacc
     1321 cgctcgtcgg tcgcggtgaa cgccacccgg acgaaacgcg cgcccgccgg gccgtagaag
     1381 tccccgggcg ccaccaggat gcccagctgc gcgaggtacg ccacggtgtc ccagcacggc
     1441 tcgtcgcggg tcgcccacag atagaggctc gcctcgctgt gctcgatccg gaagccgtgc
     1501 gcctccagcg ccgcgcgcag ggcgaggcgc cggtccgcgt agcgggcgcg ctgctcggac
     1561 acgtgcacgt cgtcgccgag cgcggcgacg gcggcggcct ggacgggggc gggcgtcatc
     1621 atcccgccgt gcttgcggat gagcagcagc tcacccagga cggccgcgtc acccgcgatg
     1681 aacgcggccc ggtatccggc caggttggag cgcttggaga gcgagtggac ggcgacgacg
     1741 ccgtcgtagt ggccgccgca gacgtcgggg tggagcaccg acaccggctc ggcgtcccag
     1801 cccagctcca ggtagcactc gtcgctgaag accagcacgc cgtgctcgcg cgcccaggcg
     1861 acgatccggg tcagctcgtc cttggacagc accttgccgg tcggattgga gggcgagttg
     1921 agccagagca gcttcagccc cgtcgggtcc agctcggtcg ggtcgtcgta gacgacgggc
     1981 tccgcgccgc agagccgggc gccgacctcg tacgtcgggt aggcgagccg ggggtaggcc
     2041 accttgtcgc ccgcgccgag cccgagctgc gtcggcagcc aggccaccag ctccttggag
     2101 ccgacgaccg gcagcacgtt ggcgtgggtc gcgccgaccg cgccgagacg ccgctccacc
     2161 cagccggtga gcgcgtcccg cagggcctcc gtaccccaca ccgtcggata gccggggctg
     2221 tccgcggcgg cgacgagcgc ccgctggacg atctcgggga ccgggtcgac cggggtgccg
     2281 acggacaggt ccacgatgcc gtccgggtgg gcctgggccg tcgacttgta gggcgcgagc
     2341 ttgtcccagg ggaagaccgg gaggcgggag gagactgcgg acacggcgct ctgctttctc
     2401 gggtgttctc gttcgggcgg cggatcggac gcacggtgcc ggatcccggc gggaccggga
     2461 tccggtgacg gtcccggcgg caccggggcc aggtgacgga ccccggtggc acgggaaaac
     2521 gcctcggccc cgcacggtga caagccgtac gggaccgggc cgcgcgcgtg gtgccgccgc
     2581 ttactggttc tgcggcggca gtccggcgat gaacgcgtgg tcgcgctcga tgagaccgag
     2641 cttggaagca ccgcccggcg agccgaggtc gtcgaagaac tcgacgttcg ccttgtagta
     2701 gtccttccac tcctccgggg tgtcgtcctc gtagaagatc gcctcgaccg ggcagaccgg
     2761 ctcacaggct ccgcagtcga cgcattcgtc cgggtggatg tacaaggacc gctggccctc
     2821 gtagatgcag tcgacggggc actcttcgat gcaggccttg tccttcacgt cgacacaagg
     2881 ctgcgcgatg acgtaggtca cgctgtcgtt cctcctcggt agggcgttgg ctctcgcgcg
     2941 ggagcgcggc gtcgtcgatg cccgcctcta gtatctccgt tctcgggcac gatccgaaca
     3001 ggaggggcgg acagagctgt ggaattcacc atcggcggac ggctggaagt ccgcatcaca
     3061 cccgctgacg tgggcaaacg cgtatccgtt cgacgccgga cggacaacgg gggcccgggc
     3121 gcggagttca ccgatgtggt cggggtgctc acatcatgga acaacggtgt gctctcgatc
     3181 acacgaaaga gcggtgaatc cgtccacatc gtggaatcct ccttggccgc cggcaaggtc
     3241 gttccggccg ccccggcccg ccgccgtggc cccgccgcct ccttcggaga gctggccgcc
     3301 gtcaccgcgc gcgcctggca gcccgtggag agcgaagcgc tgggcgactg gcggctgcgc
     3361 gccgccgggg gcttcacgcg gcgcgccaac tccgcgctgc cgctcggcga tccggggctg
     3421 ccggtcggcg aggcgctcgg acgggtccgg gactggtacg aggaacgggg cctgcccgcg
     3481 tacgtccaga cggcgaccgg ggccgagggc acgcaggagc tgctgtgcgc ggagttggag
     3541 cggcacggct ggcggcgcga ggtctcggcg gaggtgcgga tcgccgcgct ggcgccggtc
     3601 ggtgacctgg aggcggatgt gcgggcggtc cggctgaccc gcgaaccgga cgcgacctgg
     3661 ctcgcccgct accagcgctt ctccaccccc ggcccccatg tgctgcgggt gctgggcagc
     3721 ggcccttcgg tctggttcgc cacggtgccg ggggccgccg aggccaccga ggccaccggg
     3781 gacgcggcgg acgcaggggg ccgggacgcg ggaccggacg ccccgccggc cgcaatcggg
     3841 cgatgcgtcg tggacgggcg gtgggcgggt ttcatggccg tcgaggtcgc tccggagcac
     3901 cggcggcgcg gtctcgccac cacggtgatg gccgcgctgg cgcgccgggc gctggacgag
     3961 ggcgcctcgg cggcctggct ccaggtcgag gaggacaatg agggggcgcg ggcgctgtac
     4021 gacggcatgg gcttcgcggc ccaccaccgc taccaccact accgctcggc gtgacgggca
     4081 ccggaggccc ccgcgccggg ccctccggtg gatcggcgca caggagcagg gacaggaaca
     4141 tgggtcgcat atgagcgcgc tggattccgg aacggccgag cggcggcggc agttcgccga
     4201 ggaggcccgg tccgagcggc cggacctcgc cctcctgtgt ctgctgctgg gcgcggaggc
     4261 cggaccggtc ggaccgaccg aggtccgccc ggtgactccg ggggaggccg tccccgaccc
     4321 gtacggcatc gacgccgcgc agatcgagct ggaccggctg gcgggactgc tgccgtacgg
     4381 ctcccgctcc cccgccgcgt gggcctcggc gctggccgaa ctgctgggcg gacgctgtgg
     4441 gttcggcggc tcctccgtcg actaccagcg gctggactcc tcgctcctcc agcaggtgct
     4501 gcggcgccgc cggggtctgc cgatcctgtt gtcggtcgtc tggatcgagg tcgccaggag
     4561 ggcgggcgca ccggtgtacg gggtggcgct gcccggccac ttcgtggtcg gtttcggcga
     4621 tcgggagcac ccggtgctgg ccgatccgtt cgccgggggc gcgccgctga ccggtcagga
     4681 cgcggagctg ctggtcacgg gggcgaccgg ggcggccctc gaaccgtcga tgatgacgcc
     4741 cgcgcggccg ttggagatcg tgctgcggat cctgaacaac gtccgggcgt gggcggcggc
     4801 ccggcccgag cgcacggacg tggccctgtg ggcggtggag ctgtcgctgc tcctgccctc
     4861 gcatccggcc aggctccgct tcgagcgcgc ccagctcctc gtccagcgcg gtgagttcct
     4921 gcgcggggcg gcggagatgg aggaatatgc ggagatcctc gacggaatcg aaccgacgac
     4981 ggccgagaac atccggcgca aggcccacgc cgcgcgcgcc ctgctgaact gaaccggccg
     5041 tccggcgggg aatcggcgga atcctgccct gccaccggct cttggccgcc cccgtggtgg
     5101 cgagacggat gggtccgtgg gcgatgtgcg ctcccgattt acatccgaac gcccccttcc
     5161 gcgcccaacg ggcgcggaat tcggcccgtt tgtcggcgta cgcgaatgcc catgcgctca
     5221 actggatacc cgtcaccgga tgcgtacagc ccgtcgcatt ccgcgtcggg cggaccggaa
     5281 gagaaaagct gagggcagac tgatgacaac cgtgctgctg gtccacaccg tgccgttgtg
     5341 gcgcgcatcg ctggcgtcgc tcctcggcac ggggcggggg atagaggtcc gcaccgccga
     5401 acacggtgcg atacgtgccg cgttgaacgg gccgtgtccc gatgtgctcc tcaccgacct
     5461 cgaatgtccg ggcgcgctgg acgtcctcga cgaggtgaag acggtgaccg caccgcacgg
     5521 cggaccgtgt ccgctcgccg tgctcacccg cagcgatcgg ccgagcggcc tgcggcgggc
     5581 gttcgaggcg ggggcgctcg gctacatcga caagtaccgt ccggtggacg acctttccga
     5641 ggtgatgcac aaactggcgg acggggggcg gcatatcgac gagtcgctgg ccttcagcct
     5701 cctccaggtg gccgacatgc cgttatcgcc gcgggaattg agtgtgctct cgatggccga
     5761 agggggtgac accgtggccg ggattgccgg tcggctgcac ctgacgccgg ggacggtccg
     5821 caactatctg gccgccgcca tacgcaagtc cggggcacgc aatcggctgg acgccatcag
     5881 acgggcgaag gaggcggggt ggatctgatg ccgcgcgctt gcccccgccc ggtaccgacg
     5941 gccccgcccg gtccctccgg ctcccccggt ccatcctgct cgcccgggcc ctccggctcc
     6001 cccgccgtcc ccggctcccc cgtggtctcc ggctcccaga ggccggccag gtcccggtag
     6061 agggcgcagg agcgcaggag ttcgtcgggg gtgccgcact gggtgcgcgg gccgtccatc
     6121 accaggatcc gtccggcgcg gcgcgccgag ctgagccggt gcgcgacgac gaccagcgcg
     6181 cccggcaggg ccccgagcgc cagctcggcg cgggtctcgg cggccgggtc gagccggctg
     6241 gtcgcctcgt cgaggatcag cagcggcgga gcggcgagaa aggcccggcc cagggcgacc
     6301 agctgccgtt cgccctggga gagccggtcc ggttcgacgg ccgcgtcgag ggaaccgagg
     6361 cgggagagca gcgcttccag gccgatcgcg tccgccatgg ccgcgatctc ccggtcgcgg
     6421 gcgtcggggc ggaggtagcg gaggttgtcg cgcagcgagc cgctgaacac ataggcgtgc
     6481 tggggcagca ggacgcgtac ggaggtggcg tcggccgggc gcaccgggcg cccccgccac
     6541 cgcaccgctc ccccggtggg ccgctcggtc ccggcgagga cggcggccag ggtcgacttg
     6601 ccgctgccgc tcgggccgac gaccgcgagg tgctcccccg ccccgaccgt cagggagagc
     6661 cggtccagga cgggatgggc gcccggcccg tacgcgaagc tgacctcgtg gagctcggcg
     6721 accggggttc cgcgcggcgg cggggcggtg tcccgggagg gcggcgggtc ctcggcgggc
     6781 gggggcggcg cgtcggtgaa ccggtccagg accacgacga gccggccccc ggcggtgccc
     6841 agcatggtca tcagcgcctg gacggcgggg gcgagcgcct gggtgaggta ggtcagcgcg
     6901 ccgaccagcg cgcccggcgt gagcccgttc cgcagcagcc agggcgctcc caggagcagc
     6961 aggagcgggg ggaaccggcc gcagacggcg agggccagca cccgtacgcc cgaccagcgg
     7021 gccagcgagc gggaggcggc gagctgctcc tcggcgaggg tccgggactc ggccaccgtc
     7081 cgctcggcgg ctccggcggc ggcgatgtcg cgtacggagg cggcgagccg gcccgcgtgg
     7141 gcggcgtacg cctcgtcggc ggcgaggtag tcgcgctggc gggcggccat cggcggcagc
     7201 gtgccgagga acagggcgga cccgaggacc agtgggggca gcacgatcag gaggagggcg
     7261 ggagacaggg ccagcaggcc ggtgacggcc ccggccaccg tgaacacgaa cgaccgcagg
     7321 gtcaggacga gtccggccca gccgtcgcgg gcgatctcac tctgatgagt gacctgtgac
     7381 agggaccggg tgctgacgtc gccggagcgg tcgagcgcgc cggacagcgc ccgggacacg
     7441 gcgcgccgga ccagtccgtc gcgcagcggt tccacgagat ccgcgagccg gccgaacacg
     7501 ccgcgggcgg cgggcacgga gggcagcacg gcggccgcgg cgacggccag ccagaggaga
     7561 ccggtcgacg gacgtccggc gaggaagccg tcgtcgagcg cgcgggcgac cccgaacccg
     7621 ccgaggaagg tctgggcgaa ctccagcagg gaccagccgc ccagccgtag caccgctccc
     7681 gtccgggccc gcaggaaggg ccgggcctcg cggccgaccc ggcgcagcga ggtgtcccgc
     7741 cgggagggag cctcaagctg ggcatcgcgc cgggggtggt cctcaagctg ggcgtcgcgc
     7801 cgggcgcgtg ccccgtgccg cgcttcgcgc ccggggagtg cgccgcactg ctgggcttcg
     7861 cgccgtgagg cagccccaag ctgggagtcg cgctgggcgt gcgccctgtc ctgcccgtcg
     7921 cgcccggcgt gagcctcatg cggcttctcg cgccgggggc gtgctccgtc ggccttcacc
     7981 gggcctccgc tccggcggcc ggcgcgacgg gcgtacggct cgcgggcacg gagccctcgg
     8041 cgggtacgtc cgtgcggaag accgcccggt agtccgggtc cgcccagagt tcgtcgtggc
     8101 ggcccgtcgc gcggatccgg ccgtcctcaa gccaggcgac ccggtccgcc cgcgcggccg
     8161 aggacagccg gtgggcgacg atgacccggg tgcagtgccc ggcccgctcg tcgagggcgc
     8221 gccggacgtg gtgctcggtg acggtgtcga ggctggacag cgcgtcgtcg aggatcatca
     8281 ggcggccggg gtgggcgaac gcgcgggcca ggccgaggcg ttggcgttcg ccgccggaga
     8341 gcggggcgtc gacgagcggg gtggcgtagc cgtacgggag cagcgcgagg aacttgtcgg
     8401 cgcgggcggc gcgagccgcg tcgcgtacgg cttcgggcga cgcggtccag ggcccgtagg
     8461 cgatcgtgtc ctcgacggtg gtgccggtca gggccgggcg ggcgaaggcg tacgccacct
     8521 cgcggcgcag ccgggccggt tccatgccgt ccatcgggac gccgtccagc agcacgcttc
     8581 cggtgtccgg gtcgagcagc cgcccggcga ccgcggcgag caccgacttg ccggagccgg
     8641 agcgcccgac gacggccagg gaggtgccgc cggggacggt caggtgcacg ccggtgagca
     8701 gcgggccgcc gtcctgttcg acgccgacgt cgcggagttc gaggtgtccg ggggcgtcgg
     8761 gcaccgggcc caggccgcgg tgcgggagcg gtgcgagggt caggaggggg tccaggctcc
     8821 gggcggcggc gcggctgcgg gcgagggcgc cgagcgcgcc ggtcagggcg ccgatgccga
     8881 cggcgaggct cgcgtagcgg gaggcggcga ccaggtcgcc gacgccgatc gcgcccgtgc
     8941 cgaggcgcag tccggcgacc gcgaggacca gcagcatgag caggggcagc aggaggccgc
     9001 tgcggccgac ggcccgcccg tacacggccc aggtgcgcct gccgtgttcg gcgagggcgt
     9061 tcaggggttc caggacacgg cggtgctcgc gggcgccggt gcgggcggcg cggatggtgt
     9121 cggcgccgtc gagcgcctcg gtcagccggt gggcgatgag cgactgggcg cgctggtagt
     9181 cggccccggc gtcggcggtc cggcgggtga aggcgcgcag cagcgcgacg aggaggggtg
     9241 cgcccaggag gagcgcggcg gccgtccaga catcgacgag gaggaggccg acgagcgcgc
     9301 cgagcgggag caggacgccc gcgacggctc ccgcggcggt gacgggcgcg gacgcggcgt
     9361 cggcggtgcg ggcggtgagc cgggcggtga ggtcgccggt gggcagggcg agggcgcggc
     9421 ggggttcggc ggccaggacc cgggcggcgg tgcgggtgcg cagggacgcg gtgagccggg
     9481 cggtggtgct cgtgccggtc acggcggcgg ccgcgtcgaa cccggtctcg gtgagggtca
     9541 gggcggcgca gagcagcagc caggaccagg gcacggggcc gccggcgacg agccggtcga
     9601 cggtgtggcc gagggcggcg ggcagggcga gcgcggcgag cgccccgccg gtggaacaga
     9661 ggaggagccc gaggagggcc gccgggtgct gccgggcgag ccgccgggtg ccggactccg
     9721 cacccgggcg tgggtacagc cgcaaggggt ggcctttctg cccctggggg cacgtggccg
     9781 gccggcccac cggtggtgaa caccggtggg ccggccggtg cgggtcacgg ggtgcagagg
     9841 accacgctga gggagctgta ctcacagacc agcagcgaga cctggctgcc cgtggcgagc
     9901 tcgccgaagg agtcctcggc cggggtgtcc atcgcctgaa ggtcgagaag cgccatgatg
     9961 atgtcctttc ggggacgtag tggtgctgaa cggtgttgtg ctacgacccc tggtggggcc
    10021 ggtccgtggg gccgctcgcg cggccggggt gcgccgccgg ggcggcgggc aggaagggaa
    10081 gtccggtgga gccgccgagc gcggcgccca gggcgaggag ggcgccggcg gtcccggtgg
    10141 ccaggtccat cgacaggcgc atcaactgct cgccggggaa ggcgagtccg tctccgtacg
    10201 ccagggcgtg actgcccagc aggtcggtgt ggcgggcgat cgcgcgctgc cggtcggcct
    10261 cgtcgcacag cggagtggcg gcgaggtgca tgaggagtcc ggccgagccc cggagcagtc
    10321 cgggctggac gtagaaggcg gagagcgcgg ccggcaggag ggcgcggccc gccgcttcga
    10381 gcgcggggtc cgggcggtgg gccagatagg cgtcgatgac ggccgcgatg ccggcgctgc
    10441 ccgcaccgag gtacggcatc agccgcttgc cctcgacgac gaggagttcg ccgtcgtccc
    10501 cggcccggca gcgttccagg tcccggtgca gggcggtggc cgccaggtcg agcagggcgg
    10561 cgtccccggt ggtcgcgtac cggcgcacca gcagcagggc gatgccactc gcaccgtgca
    10621 acagtccggt gcggggcgac ggcgggccgt cgacgagcgc gcggacggcg agggcggtgc
    10681 agcgcgcggc cgctgcggag agcgccgggg cgtcggtggc ggaggccgag cgggccaggt
    10741 cgtcgagggc gaggccgatg cccgcgtacc cgttgtggag gccgggtgcg aggccctgca
    10801 agggctggtc gaggatgatc cggaggaggt cggcggcctc ggcggtgcgg ccgatccggt
    10861 gcagggtcca ggcgatgccg gtgagcccgt cgtagaagcc gagggggctg ccggacgccg
    10921 ggtccttggc gtgccgcagg agccagtcct cggcctcctc gcacggcggg gcgcccgtcg
    10981 cgtggagggc gtagagcact ccggccgccc cgtacgcgaa ggactggccg ccggtggcgg
    11041 tggcgaactg ggcgatgtcc ccggggaaac agcggtcctc gcgctccggt gtacaggagg
    11101 cggtgatggc ccgggccagc gcgtcacggc tgcgcggcca gtcgccgggg tcgggcagga
    11161 gcgcgggagc ggcggtggcg ccggccccgg gccgccccgt gtcgcgcagg atctccgcga
    11221 ccgcgggccg cagcgtctcc tcggtgaccg ggaagacgcg ggcgatgtcc cgggcgaggc
    11281 cggcggcctt ggtgcggtcg atgccgaaca gcgtggtgag cggcaggtac agggcgagcc
    11341 gcaggcaggc gagcgcgtag cggtcgatgt cggcgccgcg ccggtcgggc ggggcgacga
    11401 aggccgggtt ggcgacgatc tggcggcggt gttcggcggc cggggaggcc gcctcgaagt
    11461 cgagcaggac gatgcgcgcg ttctcctcgt cgaccatgac gttgctcatg tgcaggtcgc
    11521 tgatgacgat gccccggccg tgcaccgcct cgacggcgcg ctcgacctgc ccgtacaact
    11581 ccgatgccca ggccgcgtgt tcggcgagca gttcggggga cgggtgctgc cgggcgagcg
    11641 ggaagcggcg ggcgaagacg gtgttgaggg tggttccggg gatgtactgg aggaccagga
    11701 agtggtggtc gccgacctcg aacacgtccc ggacggccgg tacgcagtcc agcccggcca
    11761 gttgctccag ggcggtccgt tcgcgctcca gccgggccac ggcgtccgcc ccgtcggcgg
    11821 ccagacccgc gtacggccgc gcctccttga ggacgacctg ctcgccggtg cgggtgtcgc
    11881 ggccgaggta gaccccgccg ccgttggaga agtgcagcgc cttctccacg gtgtacggga
    11941 ggtcggccag gcccacggcg gcacgggctt cgaggtgcgg catcaggaag ccgggcgggg
    12001 tcacccagga ggggacgcgg aaggacgggc cccggtcgtc cgggacgagc cggccctgcg
    12061 gatcggcgac ggcgggcacg ggccgtccgt ccgggccgga gcagaagcgg gcggcgaacg
    12121 cgccgtaccg ggtgtgcacg gggccgttcc cgcaccgcag gtcgctgagg atgtacgggc
    12181 cgtgctcgcc ctccaggagc tgcatcaggg cggtgcacac ctcggggaac gcctcgtcgg
    12241 acggcgggta gacggtgatg aacttgccgc tgcccgcccg gtccgcgtac ttggcgttgc
    12301 ggaggcccaa cagccctgcg ttcggtacgc acttgaaggc cagccggtgt tccaggcagt
    12361 gggcgacgac ccgttccagc acggaggccg cgttgtcgag ggcggccgag acgtggatct
    12421 tccagccctg gggcggcagt cgcagcccgt cggggctgta cgcgagccag tcgccgcgcc
    12481 gggagcgggt ccagccgtcg ggtacggcgc cacggagcgg cgcgtagaac gagcgctcct
    12541 cgttggcggc tccgcccggt ccgggggaac ggtggggtgc gtcgtagaag cggcggtccg
    12601 cctggcagta cgcggcgtac tccggattca cgcacggtcc cctcgctcgg ttctttcgtg
    12661 gcgagagaga aattgtcaca acgacgcgtg gcgcccatag tcactgttgt cacgactcgt
    12721 acatgcgcgc caaccatgcg gagcgcaccg cgtactgatg ggtatccgct tgccgcccag
    12781 ccccgggcgg gtgcgggccg acggcgcgcg ggggcgcgcg aggggcgctc tcacgcccgc
    12841 tcagcccgcg ccgtgcacca ggacgtcccc cgcctccgta cggaaataga gcacggagcg
    12901 gcccgcgcgc cgacggcgga ccaggccggc ctccaggagg atccggagat ggcggcccac
    12961 cgagcccagc ccctggccgg tcagggcgac gagctgcgtc gtgctcagcg gagaggcgag
    13021 cagcagcagg acggccgccc gtgcggggcc gatcagcgct cccagggcgg cgggcacggg
    13081 gatgcgcgcg gcatcggcga gcgcgccgga gcacgggtac accagcccgt accggcgcgg
    13141 gatgtcccag cagacccagg actggtacgg ggtcacgggg acgaacagca gctgggcgcc
    13201 gtccagttcg cggggcgggt tgtcgtgggt gttgatctgg agccggctgt cgcccagcca
    13261 acggatgccg gggcgcatgc cgttcagcgc gtcgacccag ccaccgcggc ccaactgggc
    13321 cgaccgggcg atgacatcgg cctccaggat ccgccgccgt ctcggccagt cgggcagcac
    13381 ggtgtgcgtc cagacccact ccagggcgtc ggcggcacgc agggccaggt cgtcccggtc
    13441 cagcgcggcg ggcaacggcc cgcgcaccgc ctcggccagc tcggcgcggg cccggtcggg
    13501 cggggtggcc cggacgggcg tcagctcgtc ggcgaaggag ggcggggcct ggccgggcgg
    13561 ggcggggtcc ggcacgggga tgaggaagtc ggcgatccac cggggcgcga gagcggcgcc
    13621 gatcaccagc gcggagaccg ggtcgtcggc cttccaccgc cggtacgcgg gcaggtgggt
    13681 ctccagccag gcgcgctcac ccgggtgcgc ggcggtggcc cgctccagga ccagcaggct
    13741 cgcgacggcc tccgcgagcg gcgagacgac gaaccggctg ctcgcgagcg tgtccgcacc
    13801 gacctgccac catcccacgc gcccccgccc tcccgctctc cgccccggcc tgcccctgca
    13861 tggtcgcggc cagtcctccc tgccggtccg ccgcctgccc ggcctgcctg tccccgcctg
    13921 cctctgctcg cccctgcctg ccccggggct ttcgcgtccg cgcgaaacag taacggtccc
    13981 ggcggcggtg tccggagact ccaccccatg cgcacctacc gcgaactgtt ccggaccccg
    14041 gagttcaccc ccttcttcgc taccgtctcc gtgcagacgg ccgcccagac cgcgaccggc
    14101 ctggcactgg gcaccctcgt gtacacgcgg acgggctcgc ccctgctgtc ggccctggcg
    14161 atgttcggcc cgtcactggc ccaggtggcc ggggcgctca ccctgctgtc ggcggcggac
    14221 cggctgccgc cgcgcgccgc gctgaccgcc ctggcgctgc tctccgccgg ggccgcctgc
    14281 gtccaggccg ttcccgggct gccgctgtgg gccgcgttca ccgtcctgct ggcgtggggc
    14341 gcggcctcgt cacccggcgg gggcgtacgg tacgggctgc tcaacgagat cgttccgcgc
    14401 gagggattcc tgatcggtcg ctccgtgctg aacatgacgg gcggcgccat gcagatctgc
    14461 gggttcgcgg tgggcgggct gctggtggcg gtgttctcgg cgcgcggcac gctgctgatc
    14521 ggggcgggcc tgtacgtcgt cgcggcggcc gtgacccggt tcgggctgac cgcccggccg
    14581 ccccgggcca ccggccgccc gtcggtccgc gagacccggc ggacgaacgc gctgctctgg
    14641 tcgtccacgc cgcgccggta cgtgttcctg gcgctgtggg tgcccaacgg gctcgtcgtc
    14701 ggggccgagt ccctgtacgt cgcgtacgcg cccgggcacg ccgggctcct cttcgccggc
    14761 ggggccgtgg ggatgctggc cggggacacg ctggtcgggc ggttcgttgc cgtccggtgg
    14821 cgggcgcggc tcggggcccc gctccggctg ctgctcgccg cgccctacct gctcttcgcg
    14881 ctgcgcccgg ggctgcccct cgccctggcg ctggtcgtcg tggcaagcgt gggcttcgcc
    14941 gcgagtctgc tgctccagga acggctgatg gccctcaccc cgcaggagct gagcggccag
    15001 gcgctcgggc tcagctcctc ggggatgctc gcgatgcagg gtgtgggggc ggccgtggcg
    15061 ggcggtatcg cccagctgac ctcccctgcc acgggcatgg cggcggtcgc ggggctctcg
    15121 gtggcggtga cactggcgct ggccccggga ctgcgcgacc ggtccggggg cgtcgggggc
    15181 agactgccgg gagcggacgg atcaccccgg gcgtcccgta caccccacac ggaagagacc
    15241 acatgagcga caacgccagg cccagccaga aggaagccat gctctccggc gagctctaca
    15301 tcgccgacga ccccgaactg gcggcggacg cgcagcacgc ggccgtgctc agcgagcgtt
    15361 tcaacgccac ttcggccgcc gaccccgagg cccggcgcgc cgccctggcc gaactcctcg
    15421 gcgagctggg cgagggcgtg gaggtgcggc cgccgctgcg ggtcgactac ggctaccgga
    15481 cgaccatcgg cccccggacc ttcatcaact tcggcgcggt cctcctggac gtagcccgca
    15541 tcaccatcgg cgcggacgtc cagatgggcc cgaacgtcca gctgctcacc ccgacccacc
    15601 cgatcgaccc cgagccgcgc cgggccaagt gggaggccgc gcggccgatc accatcggcg
    15661 acaacgtctg gctgggcggc ggggtgatcg tctgccccgg ggtgaccatc ggcgagaaca
    15721 cggtggtcgg ggcgggggcg gtcgtcacga aggacctgcc ggcgaatgtg gtggcggtcg
    15781 gcaatccggc ccgggtgatc cggacgatcg gcgagccgga ggcgtgacac cccggggtcc
    15841 gcggcccgcc gacgcggcac cccggtttcc cgcggcccgc cccgcgcacc gcaccgcacc
    15901 gcaccgcacc gccgatacgc ggcccgcgct gcacgccccg cgctacgcgg cccgccaggc
    15961 gtcggtgacg cacgagacct cgaagtgcca ccagccctcg tcccggccgc gggcgagcag
    16021 cgccttgacc ccgcgcaggt ccgcgccgcc cggcacggtc agggcgacca gcgggaactc
    16081 cgcgctgaag acctcgcccg tgagcccgaa gacggcgagc cgctcgtgca cggcacgggc
    16141 gtcgcgcccg agcggtccgt ccggcaacgg cagcacccgt accgtgcagt tgcccgagtc
    16201 ggccacgcgg ccgacggccc agtggacccc ttcgtcgtcc gtgcggaacc gtacggtctc
    16261 gccctcggcg accccgtcct ggaggaaggg cacgttgtcc acccgcgcgg tgtccgggcc
    16321 gagccgcgtc gcccacagcc cctcggtgtc gtagggcagc cacccctcgc gcgggacgaa
    16381 gcggaaccag accttgatct gatcggcttc gcggggcggg cgttccggac cggcggggga
    16441 actcatggcc ccatggtccc ccgcgcccgg cgcgcccgcc cgtccacctc cacgaccagg
    16501 cacgacgtca gcttctgaag ccaggggccg cccccaccac gccgcaaccg ccaattcccc
    16561 aacatttgcc accagttgtt ggattcagcg gcatcttccg aggctcctga cgcacacctc
    16621 ttgacgcgta caggcccacc ggggaaacat caccgttacg agagagcgct ctcccgatac
    16681 ctccccccaa agctctcccg tccgttcgtc gtgcacccgt accacgaccc aggagacgta
    16741 cctcatgcat gctcccccca ccgcaccacg cacccgccgc cgcacccggg ccctcggttt
    16801 cgccgcgctc gccgtggcga tgctcatgtc cgtacccacc gcgcagaccg ccttcggcga
    16861 ggaggtccgg gccgtgccgg gcggcggcga cctcggtccc aacgtccatg tcttcgaccc
    16921 gtcgacgccc gacatccagg gcaaggtgga cgagatcttc aagaagcagg agtccgcgca
    16981 gttcggcacc gaccgctacg cgctgatgtt caagccgggc acgtacgacg agatcaacgc
    17041 gcagatcggg ttctacacgc agatcgcggg tctcgggctg aacccgaacg acaccacgtt
    17101 caacggcgat gtgaccgtgg acgcgggctg gttcgacggg aacgccacac agaacttctg
    17161 gcgttcggcg gagaacctga ccctcaaccc ggtcaacggc accaaccggt gggcggtctc
    17221 ccaggcggcc ccgttccgcc ggatgcacgt caagggcggc ctcaacctcg cccccgacgg
    17281 ttacggctgg gccagcggcg gctacatcgc cgacagcaag atcgacggca ccgtgggacc
    17341 gtactcccag cagcagtggt acacccgcga cagctcggtg ggcggctggg gcaacggcgt
    17401 ctggaacatg accttctcgg gcgtcgaggg cgccccggcc aacagcttcc cggagccgcc
    17461 gtacaccacg ctggacacca ccccgatctc ccgcgagaag ccgttcctct acctcgacgg
    17521 cgacgcctac aaggtcttcg tcccggagaa gcgcgagaac gcgcgcggca tctcctgggg
    17581 caacgggacg ccggcgggcg agtcgattcc gctggaccgg ttctacgtcg tgaaggaggg
    17641 ggcggacgcc gccacgatca acgcggccgt ggagcagggc ctgcacctgc tcttcacgcc
    17701 cggcgtctac cacatcgacg agacgatcac catcgatcgc gcggacaccg tggccctcgg
    17761 cctcggcctg gccacgatca tcccggacaa cggggtgacc gcgatcaagg tcggtgacgt
    17821 ggacggggtg aagctcgcgg gcctcctggt cgacgcgggg ccggtgaact cggagactct
    17881 gatcgaggtc ggccccgaga acgcctcggc cgaccactcc gccaacccca cctccctgca
    17941 ggacgtgttc gtacggatcg gcggcgcggg tcccggaaag gcgaccacga gcatcgtcgt
    18001 caacagcgac gacacgatca tcgaccacac ctgggtgtgg cgtgcggacc acggtgaggg
    18061 ctggggctgg gagaccaacc gggccgacta cggggtccgc gtcaacggcg acgacgtgct
    18121 ggcgaccggc ctgttcgtcg agcacttcaa caagtacgac gtggagtggt acggcgagcg
    18181 cggccgcacg atcttcttcc agaacgagaa ggcctacgac gccccgaacc aggaggcgat
    18241 ccagaacggc gacacgaagg gctatgccgc ctaccgcgtc gacgactcgg tcgaacagca
    18301 cgagggctgg ggcatgggca gctactgcta ctacaacgtc gacccgacga tcatccagga
    18361 acacggtttc aaggccccgg tgaagcccgg cgtgaagttc cacagcctga tcgtggtctc
    18421 gctcggcggc aacggccagt acgagcacgt gatcaacgac gtcggatccc ccacgtccgg
    18481 cccggacacg atcccctccc aggtcgtgaa cttcccgtag ccccgacgcg ggagtcgtac
    18541 gggagcgggg cccggctgct gttgagcgcc gggccccgct ccgctgtcca ggacacttcc
    18601 taggtgtgca gcgccaccgc tccgcgcgcc gggaccgtga tcgtcgccgt gccgtcttcc
    18661 gcgaccgtgg ttccgtcgcc gtcgcaggag tcgggggccg aggtgaccac gttgcagtac
    18721 gtgcccgccg gcagcgtcgt cgtgaaggtg cggttcagct ccgcgtcgcc gttgttgacg
    18781 gcgacgaagc ccttgcccgc gcgggcgaag gcgagggcgg aggagccgtc gtcccaccag
    18841 tcggtcagct ccgcgcccgc gacggcgttg tggaagccga ccatgccggt gaccgcctgc
    18901 tgggcgtgcg tgcaggtcca cgcgccggag ccgcagtcgg ccgcgccgcc gttcggcggg
    18961 ccggcgtcct tgtcggtcca ggtgtagccg gagaagacgt tcggggagcc gtagggcgag
    19021 gccagcatga agacgttggc cagggtgtag gcggcgccgt ccttgtgggt gagggtggag
    19081 ccgttgcgct cggtgtccca gttgtcgacg aacgtacggg cggaggcgcc ggccagtttg
    19141 ccgtcggcga tcgacttcag gccgggcagg ccgccgccct ggaaggcgga cttgaggtgg
    19201 ccgccgtagc ggaactcgtc gacgtccccg atcgaggtgt actcctccgg ctggaccgcc
    19261 tctcccccgc cgtggatgac ctcggtgacc cagaatcccg ggtcgcccat cttccccttg
    19321 atcgcggcga cgtcgtcggc ggacatgtgc ttggcggcgt cgatgcggaa gccgtcgacg
    19381 cccagggagc ggaggtcgga gaggtaggcg gcgatcgtcg tgcgtacggt gtcgctgccg
    19441 gtgtccaggt ccgcgaggcc gaccagttcg cagttctgga cgtcgccgcg gtcgccgtag
    19501 ttcgcgatgt ccttgcggca ggtgtggaag tcctggtccc ggaacgtgcc ggggtagtcg
    19561 tacttggtgt acgacgtgcc gcccgtcccg gtgccggagc cggcggccat gtggttgatc
    19621 acggcgtcgg ccacgacctt gaccccggcc gagtggcagc tctccaccat cgcggcgaag
    19681 gagtcccggt caccgagacg gcccgcgatc cggtagctga ccggctggta cgaggtccac
    19741 cactggtcgc cctggatgtg ctcggtggcc ggggagacct cgacgtagcc gtagccggcc
    19801 gggcccaggg tgtcggtgca ggcggtggcc accgcgtcgt acttccactc gaagagggtg
    19861 gcggtgacgg tcttctcgcc cggtggggtc gcctgggagg gccagggggc gagaaccgtg
    19921 aggccaccgg cggcgagcag gcccgccagg gttgcgcgtg cggcgcggga actcaattgc
    19981 ggctccttcg gtcgcgggta cggggcggtc gcccgtgccc ggcgtgggca gccacgcgcc
    20041 tggctgccgt ggggggagtt cggagcctgc cgttcgagaa tggacacgtc aagatgtccg
    20101 caacggtttc caggttgttt ctgaaagttc ttacgagatg gggaagttgg ggagaactcc
    20161 cgcccggaac cggcgcgaat ccggcgcaga accggcgcgc atccggcccg gaacccgccc
    20221 ggaatccgcc cggaaccggc ccggacccgc ccgccgacgg ctccgccccc ggccggatgc
    20281 gttcccgggc gggggcggag gggtggagct gctgtccggt ccgggcgtca gccctggccg
    20341 gtcaggtcga tggtgaccgt gcgctcggcg ggggtcttcc cggccagggc ggtcttcatc
    20401 gcctgggcca cgtcgtccgc gccgacctgg tgcttcttgc cgtcgccctt gaccgccatg
    20461 atgccgtcga agacgccgtc caggagcttg tcgatcgcct gcttgtcgta gacgtcgacc
    20521 agtcggccgt ccacgggctt catggagagg atctgcggca gcgaccgggc cgggccgaac
    20581 tggatctgct tgggaccggc cttgatggtg atcaggccgg acatcgcggg ctcggcgaac
    20641 tccttcatcg cccggtccag ttcggtcttg gtgatggtgg gctcgctggt ggtgacgggg
    20701 agttcgacca gccgggcctg cccggtctgc acctgggcgc ggtaggcgtc ccggaccgag
    20761 atcagggact ggccggcgtc cagcgtcttg cccggcttgc ccggcaccgc cacggccttg
    20821 ttcggctcga agcggatcgt gccgtcgttg gacgatccgg agacgcccgc caggtcggtc
    20881 agcgccacac cgagcttctc ctcgtcgacc gggatcaccg gatcggcggg acgctccccg
    20941 ccgaacagcg agccgatcac cgagacgggg ttgtagtcgc tgcccgccgc gccgcgcacg
    21001 gtctcctggc tgtccagggt gagaccggcc ttctcggggt cgagcttctc ctccttgccg
    21061 tcgaccgaca gcgtcagggg cgtcttggcc cgctccccga gggcggcttc gagcttggtg
    21121 acggcctcct ccttcgtgcc gccgccgatg tcgacgccga gcaccgtggt gcccttgggg
    21181 acctcggagt ggttcagcag gagacccgcc ccgtacgcga tgccgaccag cacgaccgcg
    21241 gccaccccga ggaggaccag cttggagcgg cccttcttcg cgggggcggc ggtcgcctgg
    21301 gacgcgggac gcggggcggc ggggccgggc gcgggaacgc cggggccacc cgggccgccg
    21361 gggccgccct ggggtccgcc ggccgccggg ccgccgggga tgccggagat cccggggccg
    21421 cccgggaacg cggcgcgggg ctcgctgggc accacgggga tgccgctggt cagcgtgtcg
    21481 cccgagacat ggccggaacc gggctcgggc gccggggcct gcggcgtgag gatcgcggtg
    21541 tcgtcggaca tccggggcgg tacggcgccg gggacgcccg ggaccatcgg cccggggccg
    21601 ccgaggccgg ggacgccgtc gaggttcggg gtcagcgagg agctgccggt gaccggtccc
    21661 gtggtggggc cggacggacc ggacgggccg ggcgggcgca ccccgaggcc gggggtggag
    21721 cgggggcctc cgccgggggg ctcggtgccg tagccgtcga gcgcgctgcg gccggggccg
    21781 ggcgtgcccg gtccgccacc ggactgcggg gcgtccgaga agtacggcag atcgggacgc
    21841 gagcggcccg catcgccgtc ggccccgcca ccgggaccgg cggaaccgtc cgcgctcggg
    21901 ccaccgggac cgccgggacc gcccgtgccg gggccctggg cgccgccgga accggaagga
    21961 gcgccgccgc cggaggcccc gggcgcaccg gcgccctggg cggctgttcc cggcccggtg
    22021 gccggggtct tgcgcggggc gaaccagtcg ctgccgctct tctcccggcc cggcttctcc
    22081 gcgggcgtcg ggtcggcggc cgggccgccg tccccgggcc ggtccgcggg cgccgcgccg
    22141 ttcgggcccg cggcgcggtc cgaagatccg gctccgggcg cgggcggcgg tgtgccgggg
    22201 cgcggggtgg cgccggtccg ctccgcgtcg gaacggccgc cggagatgtc gctctccgcc
    22261 atcggcgtac gcatcacgac cggcgggatg ggacgcgacc cggggatgtt gatccggatg
    22321 cgcgtcgtca gcgtcgtctc ggtcttcggt tcctcgggcc ggggcggagc caccgattcc
    22381 gggttctcgt cagagccgtc ctgcgacggg tggagcgacg gatactggcg ggatccgtac
    22441 ggcggcgtac ccgaggggta cgcggctccg ccgcggccct gggggccgga ggacgaactg
    22501 tcagtttcac gactcaaagc aggttctccc gattggctcc gccgcccgta cttcccccat
    22561 gccgcaggcc aggggacggc tcggcgcgcg caccaccata ctggccgccg ccgtcggaca
    22621 ctccgcgacc g
//
