LOCUS       NZ_KZ195572            12853 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. CS057 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ195572
VERSION     NZ_KZ195572.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS057
  ORGANISM  Streptomyces sp. CS057
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Gonzalez-Montes,L., Perez-Victoria,I., Sialer,C.,
            Brana,A.F., Garcia Salcedo,R., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Searching for Glycosylated Natural Products in Actinomycetes and
            Identification of Novel Macrolactams and Angucyclines
  JOURNAL   Front Microbiol 9, 39 (2018)
   PUBMED   29441046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Searching for glycosylated natural products in actinomycetes
            isolated from leaf-cutting ants: activation of two silent clusters
            and identification of a novel macrolactam
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8333859)
  AUTHORS   Malmierca,M.G., Mendez,C., Olano,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2017) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 265.32x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002188345.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 02:40:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,152
            CDSs (total)                      :: 7,074
            Genes (coding)                    :: 6,991
            CDSs (with protein)               :: 6,991
            Genes (RNA)                       :: 78
            rRNAs                             :: 10, 6 (16S, 23S)
            complete rRNAs                    :: 10, 6 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 23 of 83
            Pseudo Genes (incomplete)         :: 71 of 83
            Pseudo Genes (internal stop)      :: 4 of 83
            Pseudo Genes (multiple problems)  :: 14 of 83
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:25:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1906370
            Orig. end                         :: 1919223
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ195572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Salas's laboratory, A.
            Microbiology, University of Oviedo, Spain.
FEATURES             Location/Qualifiers
     region          1..12853
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="15"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12853
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12853
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7853](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7853)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    complement(136..152)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    complement(138..148)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            181..891
                     /locus_tag="B9W61_RS07760"
                     /old_locus_tag="B9W61_07760"
     CDS             181..891
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128212.1"
                     /locus_tag="B9W61_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07760"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_047179242.1"
                     /transl_table=11
                     /translation="MSELKSRKLISVQEHLRDQVAGALRAALIAGELQPGVIYSAPTLA
                     AEYGVSATPVREAMLDLAREGLVEAVRNKGFRVTELSERDLDEYTEIRALIEIPTIGRV
                     TRTASREQLEAVRPVAEEIVTAAQGGDLIGYLESDRRFHLDLLALAGNARLVETVADLR
                     KRSRLYGLTDLSQEGSLVGSAREHTALLDIMIAGDAEGAEEHMRRHLAHVRTLWAARKR
                     EAERAAPSRKLGAR"
     gene            complement(1069..2010)
                     /locus_tag="B9W61_RS07765"
                     /old_locus_tag="B9W61_07765"
     CDS             complement(1069..2010)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957033.1"
                     /locus_tag="B9W61_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07765"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_087764624.1"
                     /transl_table=11
                     /translation="MTVTLDAADVFALGPAGAVAAVREALAGGLDPDGDVPRAVVPLAH
                     GQGLLMPSESGGWFGVKIATVAPGNAARGLRRINATYLLHDSATLTPVALLDGVALTTL
                     RTPAVSVAACLDRLRALAAVSGGLRLVVFGAGPQGEGHVAAVRAHVPVAAVTVVTRSEG
                     PVPGWADRRLAAADGEVAASVRRADVVVTATSARRPVVDGRLVRDGAVVLAVGSHEPDA
                     RELDSVLMGRATVVVESRATALREAGDVVLAIHEGSLDPDDLVTLADPTGSRGDVPADR
                     PLVVKTCGMGWQDLVVAVAAHRRKEATPAERS"
     gene            complement(2007..3083)
                     /locus_tag="B9W61_RS07770"
                     /old_locus_tag="B9W61_07770"
     CDS             complement(2007..3083)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454570.1"
                     /locus_tag="B9W61_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07770"
                     /product="proline racemase family protein"
                     /protein_id="WP_087764625.1"
                     /transl_table=11
                     /translation="MTTDPYAVPIGAAYTGPIDTVDWHTGGEPFRIVPASPPAVTGHGP
                     TVAERRTAAMADPGVQWTRALLCGEPRGHADMYGAFLVPPDDAGAHLGALFWHKDGFST
                     ACGHGTIALGAWAVATGLVPAPADGTTDVVIDVPSGRVTASVRTAGGRVADVTFVNVPG
                     HVHARGVEVATSLGTVTVDIAYGGAMYAVLPAHRLGLRVRPRDVTAIVAAGREIRDALN
                     AARAAEHPEDDRLSGVYGTVFTEEAGAPVERPDGTWLLHHRNVTVFADGQVDRSPCGSG
                     TAARVALLADAGELRLGDELRHESVVGSTFRARIERSSTVHGRPSVVPAVTGTAYATGT
                     SRFTVDPDDALVPGFVLR"
     gene            complement(3080..4081)
                     /locus_tag="B9W61_RS07775"
                     /old_locus_tag="B9W61_07775"
     CDS             complement(3080..4081)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378674.1"
                     /locus_tag="B9W61_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07775"
                     /product="proline racemase family protein"
                     /protein_id="WP_087764626.1"
                     /transl_table=11
                     /translation="MRSKVCYHAVDSHTEGMPTRVVTGGVGVLPGATMAERRQRFMAER
                     DGLRTLLMCEPRGHGAMSGAILQPPTRPDADFGVLFIEVSGCLPMCGHGTIGVATVLVE
                     TGMVEAVEPETLIRLDTPAGLVTARVAVRDGRAESVTLENVASYSHALDQVVDVEGFGP
                     VRYDMAYGGNFYAIVRTEDLGIPFDRAEKGRLLEAGLAVMGAINERNPVVHPENPAIDV
                     CHHVYLEAPGSTAEHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLKAGQDFVNES
                     FIGSRFTGRILGETTVGGRPAVLPSVTGRAWITGTAQYLLDPTDPYPTGFTV"
     gene            complement(4083..4991)
                     /locus_tag="B9W61_RS07780"
                     /old_locus_tag="B9W61_07780"
     CDS             complement(4083..4991)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454567.1"
                     /locus_tag="B9W61_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07780"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_047179238.1"
                     /transl_table=11
                     /translation="MDRTSLPARMPWHGVIVATSLPFDQDLAVDHGAFGENVAWLAEQG
                     LHGVAPNGSLGEYQTLTYEERDRVVETAVANAPEGFTVMPGVGAYGAIEARRHARFAKD
                     AGCQAVMCLPPNAYRADDRAVLEHYAMVASAGLPVTAYNNPIDTKVDLRPELLAKLHAE
                     GFIVGVKEFSGDVRRCYAINELAPGLDLIIGTDDTLLEVGVAGAKGWVAGYPQVFPRAC
                     LDLYNASLAGDLDTALPLYRQLHSVLRWDSRTEFVQAIKLGQDMIGRTGGVCRPPRQTL
                     DPETEAVVRAATQALIDAGVN"
     gene            complement(5001..6440)
                     /locus_tag="B9W61_RS37210"
                     /old_locus_tag="B9W61_07785"
     CDS             complement(5001..6440)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891273.1"
                     /locus_tag="B9W61_RS37210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07785"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_087764627.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.3e-22, bitscore:
                     78.3, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 7.4e-11, bitscore:
                     41.0, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEAADLVVVGAGPAGMAAAATALDGGLRVVLVDSGAAPGGQFWR
                     HPPLPAREALPTADLHHGLNTYRALCATLSAHERTGRLTLLLNHHVWTTAREEDGFAVH
                     AVDRGRAPEERAVALRAPALLVATGAYDRQLPFPGWDLPGVLTAGGLQSLLKGGGVVAG
                     SRVVLGGTGPFLLPVAAALAARGAKVVAVCEAAAPSAWLRHPAALLRNPAKWAEGARYA
                     ATLARHRVPVRTRTAIVGAEGEGRVAVVRTAALDAAGRPLPGTERRIEADTVGVGWGFV
                     PQLDLLLPLGCDLADAGDGTVAAAVDDGQRTTVPGLYTAGETCGVGGAALAVSEGRVAA
                     VSVLTDLSAPARPGPRRPAAELRAVARHRAFARAMAQAHPLPPAWPAWLTDDTPVCRCE
                     EVTAGAVRAARADDAAADHRQVKQLTRAGMGWCQGRMCGPAVHCLVSARDQPYAPAERL
                     IATPVTLGALADSGEPTTDPS"
     gene            complement(6433..6696)
                     /locus_tag="B9W61_RS07790"
                     /old_locus_tag="B9W61_07790"
     CDS             complement(6433..6696)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454563.1"
                     /locus_tag="B9W61_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07790"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_007454563.1"
                     /sec_met_domain="Fer2_4 (E-value: 5.8e-24, bitscore: 82.7,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVTAFTVDGEPLPFVPGQTLAAALVASGRVAWRTTRGGQRPRG
                     IFCGIGVCYDCLVTVDGTGGQRACLVQARAGMAVTTGEGDDE"
     gene            complement(6693..7853)
                     /locus_tag="B9W61_RS07795"
                     /old_locus_tag="B9W61_07795"
     CDS             complement(6693..7853)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454561.1"
                     /locus_tag="B9W61_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07795"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_047179237.1"
                     /sec_met_domain="DAO (E-value: 3.4e-68, bitscore: 229.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 7.6e-05,
                     bitscore: 20.4, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVVVGAGIVGAACAFHAVAAGLDVTVLDRGPVGAGTTSRGEGN
                     ILLSDKEPGPELELARLSRDLWDEVGEELGPETVEFETKGGLVVASTPDALGALHAFAE
                     RQAAAGVRTEAVERVGELEPHVAPGLPGGVHYPQDAQVQPVLAAAGLLRAAVRRGARTH
                     TGEAVAAVTGTDGRITGVRTADGTVLPADAVVNAAGTWGGEVGRRLGAPVEILPRRGFV
                     LVTEPLPPMIRHKVYSADYVANVASSDEGLETSCVVEGTRAGTILIGASRERVGFDTSM
                     NPAVVATLAAQACRLFPFLRGVHLIRAYRGFRPYCPDHLPVIGPDPRVPGVVHACGHEG
                     AGIGLAPGTGALVTAQLLGRPWRGADPAAHTGLLPDRFLTTGGVPK"
     misc_feature    complement(7838..7852)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.01"
                     /tool="antismash"
     misc_feature    7863..7879
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.81"
                     /tool="antismash"
     misc_feature    7867..7877
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    7879..7899
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.93"
                     /tool="antismash"
     gene            7999..9669
                     /locus_tag="B9W61_RS07800"
                     /old_locus_tag="B9W61_07800"
     CDS             7999..9669
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454559.1"
                     /locus_tag="B9W61_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07800"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_087764628.1"
                     /sec_met_domain="Aldedh (E-value: 5.3e-49, bitscore: 165.7,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTGNPAPPADSHPTGPTPLTEPTPLSGPTPLTGHSLLSGHSLL
                     AGREVPGTGDAWYAVAAATGEPFGPPHRDASAEQVAEAARLAAADARAFRALPPERRAA
                     FLDACAEEIEALGDALPALAARETGLPTARLNGERERTCGQLRLFAELVRDGGALGARI
                     DSGPSGTDVRLRRVPLGPVAVFGASNFPLAFSVAGGDTASALAAGCPVVVKAHPAHPGT
                     SEAVARAVTAAAARTGMPAGVFSLLVGRGHDVGLALVGDPRITAVGFTGSRAGGLALIA
                     AGRSRPVPVPVHAEMSAVNPVIMLDGALAEPEPAAASYVASLTAGAGQFCTNPGLLLLP
                     AGPAGDAFLSAAAQALKAAEGQVMLTPGIARAYSEGVRRWENVPGVREVARGAAGAGPY
                     APAPVVLACDAAVYTAHQELTGEVFGAAGLVVRWSDTGELLGLLAGLEGQLTATLHAAD
                     ADRATALELLPVLEERAGRVLWGGWPTGVEVCHAMVHGGPWPATSSPGTTSVGTLAVER
                     WLRPVCYQSFPDDLLPPELRDANPLRVPRQTGSGRTRGA"
     gene            complement(9977..12622)
                     /gene="alaS"
                     /locus_tag="B9W61_RS07805"
                     /old_locus_tag="B9W61_07805"
     CDS             complement(9977..12622)
                     /EC_number="6.1.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alaS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018099998.1"
                     /locus_tag="B9W61_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B9W61_07805"
                     /product="alanine--tRNA ligase"
                     /protein_id="WP_087764629.1"
                     /transl_table=11
                     /translation="MRTADIRQRFLDHFAARGHTVVPSAPLPTPDPTLLFVNAGMVPFQ
                     PYFTGEATPLWQRATSVQKCVRTLDIEEVGKTTRHGSFFQMNGNFSFGDYFKEEAIAFA
                     WDLSTKPQADGGYGLDPERIWVTVHHSDTESRGIWRAVAGLPDERIVERGDEDNFWSMG
                     VPGPCGPCSELYYDRGPALGREGGPAVDEDRYMEFWNLVFMQYERGEGPGKSGYPILGE
                     LPRRNIDTGMGLERMATLLQGKDNLYEIDETRPVLDRAAELAGVRYGADAESDVRLRVV
                     ADHVRTALMLLADGTAPGNEGRGYVLRRILRRSVRSMRQLGFHDPALPELLPVARDCMA
                     PSYPEVVESYARISDQAYGEEDAFRATLRQGTTVLDTAVAKVKDEGGRSLPGAKAFLLH
                     DTYGFPIDLTLEMAAEQGVEVDRDGFTALMNAQRERARADARARKSGGAADTAALRTVL
                     DSHGPTDWRAWSTLTTESRVLALLGTEGPVPVARTGDLVTVILDRTPFYAESGGQDSDA
                     GLLAGASVEAEVVDVQRPLPGLVAHQVRVTAGELAVDDTVHAAVDAEWRLGARQAHSGT
                     HVLHAALREILGPTALQSGSYNRPGYLRLDFPWRGALSPAVRSEVEEAANRALRRDLPV
                     GVRWMTLPEAKELGALALFDETYGEKVRVVEIGGAWSRELCGGTHVEHAAQIGTVALTA
                     ESSVGAGMRRLEAAVGIEGFGYLARERDLVARIAEQLNAPRAELPERIAGLLDRLKAAD
                     RENARLKQQATAARAAELAGGGVDVDGVRVVTATAGGGADEARALATAVRDRLPVGTPG
                     AVGIGTGTGVVVVALNKAAREAGLNAAALVKQLLGGRGGGSPELAQGGGLEADRLADTL
                     VELPRVIAGR"
ORIGIN
        1 acctggtgat cacggcggac ggggcgaagc tgctctccgg cgcgctgccc cgtacggtcg
       61 acggtgtcga ggggtggatg gcccgcctcc tggacagctg acagcaccgg ccttcgagcg
      121 atggggcacc gcgcaacgtg acattgtata gtgcggtgcc acatctttga aggggaatgc
      181 atgagtgagc tgaagtcccg caaactcatc tcggtgcagg agcatctgcg cgaccaggtg
      241 gcgggcgccc tgcgtgccgc gctgatcgcg ggggaactcc agcccggtgt gatctactcg
      301 gcgcccacgc tcgccgccga gtacggcgtc tccgccactc ccgtgcgcga ggccatgctg
      361 gatctggccc gcgagggcct ggtcgaggcc gtgcgcaaca agggtttccg cgtcaccgag
      421 ctctccgagc gcgacctgga cgagtacacc gagatccgcg ccctcatcga gatccccacc
      481 atcggccgcg tgacccgcac cgcctcccgc gagcagttgg aggcggtgcg tccggtggcc
      541 gaggagatcg tgaccgccgc gcagggcggc gacctgatcg gctacctgga gtcggaccgc
      601 cgcttccacc tcgacctgct cgccctcgcc gggaacgccc gcctcgtgga gaccgtggcc
      661 gacctgcgca agcgctcccg gctctacggg ctcaccgacc tgtcccagga ggggtcgctg
      721 gtgggttcgg cgcgcgagca caccgcgctc ctggacatca tgatcgcggg ggacgcggag
      781 ggggccgagg agcacatgcg ccgccatctc gcgcatgtgc ggaccctgtg ggcggcccgt
      841 aagcgcgaag ccgaacgcgc cgccccgtcc cgcaagctcg gcgcgcgctg acaccgaagt
      901 acgggcgggg cggcgcgcgt tgacaccgaa gtacgggcgg ggcggcgcgc gttgacgcgc
      961 cgaggccgcc ggctccgtgc cgtgcgccgg gaagtcgggg tggggcggag cgtgtcgacg
     1021 tgacggaccg ccggcgggcg cggtgtcgcg gcccgcttcg gcggacggtc agctccgctc
     1081 cgccggcgtc gcctccttcc gccggtgggc cgcgacggcg accaccaggt cctgccagcc
     1141 catcccgcac gtcttcacga ccagcggccg gtcggccggg acgtcccccc gcgaaccggt
     1201 cggatccgcc agggtgacga ggtcgtccgg gtcgagcgag ccctcgtgga tcgccaggac
     1261 gacgtcgccc gcctcgcgga gggcggtcgc ccggctctcc accacgacgg tggcacgccc
     1321 catcagcacg ctgtcgagct cccgcgcgtc cggctcgtgg gagccgaccg ccaggaccac
     1381 cgccccgtcc cgcaccagcc gcccgtcgac caccgggcgg cgcgcggacg tcgcggtgac
     1441 gacgacgtcc gcgcgccgca ccgaggccgc cacctccccg tcggccgccg ccaggcgacg
     1501 gtcggcccag ccgggcacgg gcccttcgct ccgggtgacg accgtgacgg cggccaccgg
     1561 tacatgggcc cgtacggcgg cgacgtgccc ctccccctgg gggcccgcgc cgaagaccac
     1621 caggcgcagc cccccgctaa cggcggccag cgcgcgcagc cggtccaggc aggccgcgac
     1681 cgagacggcg ggggtgcgca gggtcgtcag cgccaccccg tccagcaggg ccaccggcgt
     1741 cagggtcgcg ctgtcgtgca gcagatacgt ggcgttgatc cgccgcagcc cgcgcgcggc
     1801 gttgccgggc gcgacggtgg cgatcttcac gccgaaccag ccgccggact cggagggcat
     1861 gagcagcccc tgaccgtggg ccagcggcac gaccgccctc ggtacgtcgc cgtccgggtc
     1921 gagccccccg gccagcgcct cccggaccgc ggcgacggcc ccggccggac cgagcgcgaa
     1981 cacgtccgcg gcgtcgagcg tcaccgtcat cgcagcacga acccgggtac gagggcgtcg
     2041 tcggggtcga cggtgaagcg gctggttccc gtggcgtacg cggtgcccgt cacggccggg
     2101 acgaccgagg ggcgcccgtg gaccgtgctg gaccgctcga tccgggcgcg gaaggtggag
     2161 cccaccaccg actcgtgccg cagctcgtcg ccgaggcgca gttccccggc gtcggcgagg
     2221 agcgccaccc gggccgcggt gccggagccg cacggggagc ggtcgacctg gccgtccgcg
     2281 aacaccgtga cgttgcggtg gtgcagcagc caggtgccgt cgggccgttc gacgggggcg
     2341 ccggcctcct cggtgaacac ggtcccgtag acgccggaca gccggtcgtc ctcggggtgt
     2401 tcggcggcgc gggcggcatt cagcgcgtcg cggatctcgc ggccggccgc gacgatcgcg
     2461 gtgacgtcac gcggccggac ccgcaggccg agccggtgtg ccgggagaac ggcgtacatg
     2521 gcgcccccgt aggcgatgtc gacggtgacg gttcccagcg aggtggccac ctcgacgccg
     2581 cgcgcgtgga catggccggg gacgttgacg aacgtcacgt ccgcgacgcg gccgccggcc
     2641 gtgcgcacgc tcgccgtgac ccggccggag gggacgtcga tgacgacgtc cgtcgtgccg
     2701 tcggccgggg ccgggaccag gccggtggcg accgcccagg cgccgagggc gatcgtcccg
     2761 tggccgcagg ccgtggagaa gccgtccttg tgccagaaga gggccccgag gtgggccccc
     2821 gcgtcgtccg gcggcaccag gaaggccccg tacatgtcgg cgtggccgcg cggttcgccg
     2881 cacagcaggg cccgggtcca ctgcaccccg gggtcggcca tggcggccgt gcggcgctcg
     2941 gcgaccgtgg gcccgtgccc ggtcacggcc ggcggggacg cgggcacgat ccggaacggt
     3001 tcacccccgg tgtgccagtc gaccgtgtcg atcggcccgg tgtacgccgc cccgatcggc
     3061 acggcgtacg gatcggtcgt cataccgtga atcccgtcgg ataggggtcg gtggggtcga
     3121 gcaggtactg cgcggtcccg gtgatccagg cgcggccggt gaccgagggc agtacggcgg
     3181 gtcggccgcc gaccgtggtc tcgccgagga tgcggccggt gaagcgggag ccgatgaagg
     3241 actcgttgac gaagtcctgc ccggccttca gcagcccccg cgcgtgcagt tgggccatgc
     3301 gcgcgctggt tcccgtcccg cagggcgagc ggtcgaacca gccggggtgg atcgccatgg
     3361 cgtgccgcga gtgctcggcg gtcgagccgg gcgcctccag atagacgtgg tggcagacat
     3421 cgatcgcggg gttctccgga tgcaccaccg ggttccgctc gttgatcgcc cccatgacgg
     3481 ccaggcccgc ctccagcagc cgccccttct ccgcccggtc gaaggggatg ccgaggtcct
     3541 cggtgcgcac gatggcgtag aagttgccgc cgtacgccat gtcgtagcgg accgggccga
     3601 acccctcgac gtcgacgacc tggtccagcg cgtggctgta ggaggcgacg ttctccaggg
     3661 tgacggactc cgcgcggccg tcgcgcacgg cgacccgcgc cgtgacgagg ccggcggggg
     3721 tgtcgaggcg gatgagcgtc tccggttcga ccgcttcgac catgcccgtc tccacgagga
     3781 ccgtcgccac gccgatggtg ccgtggccgc acatgggcag acagccggag acctcgatga
     3841 acagcacgcc gaagtcggcg tcgggccggg tcgggggctg gaggatggct ccggacatgg
     3901 ccccgtgtcc gcgcggctcg cacatgagca gggtgcgcag cccgtcgcgc tccgccatga
     3961 accgctgccg tcgctcggcc atcgtggcgc cgggcaggac gcccaccccg ccggtgacga
     4021 cccgggtcgg catgccttcg gtgtgcgagt cgaccgcgtg gtaacagacc ttgctgcgca
     4081 cgtcagttca ccccggcgtc gatgagtgcc tgggtggcgg cgcggacgac ggcctcggtc
     4141 tccgggtcca gggtctgccg gggcgggcgg cagacgccgc cggtgcggcc gatcatgtcc
     4201 tggccgagct tgatggcctg gacgaactcg gtcctgctgt cccagcgcag tacggagtgg
     4261 agctgccggt agagcgggag cgcggtgtcg aggtcgccgg ccagcgaggc gttgtagagg
     4321 tcgaggcagg cgcgcgggaa gacctggggg tagccggcga cccagccctt ggcgccggcg
     4381 acgccgactt ccaggagggt gtcgtcggtg ccgatgatca ggtcgagtcc gggggcgagt
     4441 tcgttgatgg cgtagcaccg gcggacgtca ccggagaact ccttcacgcc cacgatgaat
     4501 ccctcggcgt gcagcttggc cagcagctcc gggcgcaggt cgaccttggt gtcgatgggg
     4561 ttgttgtagg cggtgacggg aagtccggcg gaggccacca tcgcgtagtg ctccaggacg
     4621 gcacggtcgt cggcccggta ggcgttgggc ggcaggcaca tgacggcctg gcagccggcg
     4681 tccttggcga accgcgcgtg ccgcctcgcc tcgatcgcgc cgtacgctcc gacgcccggc
     4741 atcacggtga agccctcggg ggcgttcgcg acggcggtct ccacgacgcg gtcgcgttcc
     4801 tcgtacgtca gggtctggta ctcgcccagc gagccgttcg gggcgacgcc gtgcaggccc
     4861 tgctcggcga gccaggcgac gttctcgccg aaggcgccgt ggtcgacggc gagatcctgg
     4921 tcgaagggga ggctcgtcgc gacgatgacg ccgtgccagg gcatgcgggc gggaagggag
     4981 gtgcggtcca tgggaactcc tcagctggga tcggtggtgg gctcgccgga atcggcgagc
     5041 gcaccgaggg tgacgggggt cgcgatcagc cgctcggcgg gtgcgtaggg ctggtcgcgg
     5101 gcggagacga ggcagtgcac ggcgggcccg cacatccggc cctggcacca gcccatgccg
     5161 gctctggtca gttgtttgac ctgtcggtgg tcggctgccg cgtcgtcggc gcgggcggcc
     5221 cggaccgccc ccgcggtgac ctcttcgcac cggcagaccg gtgtgtcgtc ggtcagccag
     5281 gcgggccagg ccgggggcag cgggtgtgcc tgtgccatcg cccgggcgaa ggcacggtgc
     5341 cgggccaccg cccggagctc cgcggccggg cggcgggggc cgggccgggc cggggcggag
     5401 aggtcggtga gcaccgagac ggcggcgacg cggccctcgc tcaccgcgag tgcggccccg
     5461 cccacgccgc aggtctcgcc cgccgtgtac agcccgggca ccgtggtgcg ctgtccgtcg
     5521 tcgacggcgg cggccacggt gccgtcgccg gcgtcggcga gatcgcagcc gagcgggaga
     5581 agcaggtcga gctgggggac gaagccccag ccgacgccca cggtgtcggc ctcgatccgg
     5641 cgctccgtgc ccgggagcgg gcgcccggcg gcgtccaggg cggcggtgcg cacgacggcg
     5701 acccgcccct ccccttcggc gccgacgatc gcggtgcggg tccggaccgg gacgcggtgc
     5761 cgggcgaggg tggccgcgta ccgggcgccc tcggcccact tggcggggtt gcgcagcagg
     5821 gccgcggggt ggcgcagcca ggccgagggc gcggccgcct cgcagacggc gacgaccttc
     5881 gccccgcgtg cggcgagggc ggcggcgacc ggcagcagga aggggccggt gccgccgagg
     5941 accacccggc tgcccgcgac gactcccccg cccttgagca gcgactggag cccgccggcg
     6001 gtgagcaccc cgggcaggtc ccagccgggg aaggggagtt ggcggtcgta ggcgccggtc
     6061 gccaccagca gggccggtgc ccgcagcgcg acggcccgct cctcgggcgc ccggccccgg
     6121 tccacggcgt ggacggcgaa gccgtcctcc tcgcgggccg tggtccacac atggtggttc
     6181 agcagcagcg tgagccgtcc ggtgcgctcg tgggcggaga gggtggcgca gagcgcccgg
     6241 taggtgttca gcccgtggtg cagatcggcg gtcggcaggg cctcgcgcgc ggggagcggg
     6301 gggtggcgcc agaactggcc gcccggggcg gcgcccgagt cgacgaggac gacccgcagc
     6361 ccgccgtcca gggcggtggc ggcggcggcc atgccggccg ggcccgcgcc caccaccacg
     6421 aggtcggcgg cctcactcat cgtcgccctc ccccgtcgtg acggccatgc ccgcgcgggc
     6481 ctgcaccagg caggcgcgct gcccgcccgt tccgtcgacg gtgaccaggc agtcgtaaca
     6541 gacgccgatc ccgcagaaga tcccccgggg ccgctgtccg ccccgggtgg tccgccaggc
     6601 gacccggccc gaggcgacga gcgcggcggc cagggtctgt cccggtacga acggcagcgg
     6661 ttcgccgtcc acggtgaacg cggtcactgc ggtcacttcg gcacacctcc ggtggtgagg
     6721 aatcggtcgg gcaggaggcc ggtgtgggcg gccggatcgg cgccgcgcca cgggcggccg
     6781 aggagttggg cggtgaccag ggcgccggtc ccgggggcga ggccgatgcc ggcgccctcg
     6841 tggccgcacg cgtggacgac gccggggacg cgggggtccg ggccgatgac cggcagatgg
     6901 tccggacagt acggcctgaa cccccggtag gcgcggatca ggtggacgcc gcgcaggaac
     6961 gggaagaggc ggcatgcctg ggcggcgagc gtggccacca cggccgggtt catcgaggtg
     7021 tcgaagccga cgcgttcacg gctggcgccg atcaggatcg tgcccgcgcg ggtcccctcg
     7081 acgacgcacg aggtctccag accttcgtcg ctggaggcga cattggccac gtagtcggcg
     7141 gagtagacct tgtgccggat catcggcggc agcggctcgg tgacgaggac gaagccccgg
     7201 cggggcagga tctcgacggg ggcgccgagc cggcgaccga cctctccgcc ccaggttccg
     7261 gcggcgttga ccacggcgtc ggcgggcagc accgtgccgt cggcggtgcg cactccggtg
     7321 atcctgccgt cggtcccggt gaccgcggcc acggcctcgc cggtgtgcgt ccgggccccg
     7381 cgccggaccg cggcgcgcag cagtccggcc gccgcgagca cgggctgcac ctgggcgtcc
     7441 tgcgggtagt ggacgccgcc ggggaggccg ggcgcgacat ggggttcgag ttcgccgacg
     7501 cgctcgacgg cttcggtgcg gacgcccgcg gccgcctggc gctcggcgaa cgcgtgcagg
     7561 gccccgagcg cgtcgggggt gctcgcgacg acgaggccgc ccttggtctc gaactcgacg
     7621 gtctccggtc cgagttcctc gccgacctcg tcccagaggt cgcggctgag ccgggccagc
     7681 tccagttcgg ggccgggctc cttgtcggag agcaggatgt tgccctcccc ccggctggtc
     7741 gtgcccgcgc cgacgggacc acggtcgagg accgtgacgt cgagccccgc cgcgacggcg
     7801 tggaacgcgc acgcggcgcc cacgatgccc gctccgacga cgacgacttt catggccgct
     7861 ccctagtaca atgtcacatg ccattgctta ggctatacat ccggacggcc cgaggacaac
     7921 gccaccaccc cggtgacttt cacccgggca cccgacgacc gcgcgccgcc accggcgcgc
     7981 acagggagac gcatcgctgt gaacccgacc ggaaaccccg ctccgcccgc ggactcgcac
     8041 ccgaccggcc ccacccctct gaccgaaccc acccccctgt ccggacccac ccctctgacc
     8101 gggcactcac tcctgtccgg gcactcgctc ctggccggcc gcgaggtccc cggcaccggg
     8161 gacgcctggt acgcggtcgc cgccgcgacc ggcgaaccgt tcggcccccc gcaccgggac
     8221 gcctcggcgg aacaggtcgc cgaggcggcc cggctggccg cggcggacgc ccgcgccttc
     8281 cgcgccctgc cgcccgagcg gcgggcggcc ttcctcgacg cctgcgcgga ggagatcgag
     8341 gcgctcggcg acgccctgcc ggcactcgcg gcccgggaga ccgggctccc gacggcccgg
     8401 ctgaacggtg aacgggagcg cacctgcggg cagttgcgcc tcttcgccga gctcgtcagg
     8461 gacggcggcg ccctcggcgc ccggatcgac tccggcccct cgggcacgga cgtacggctc
     8521 cggcgggtgc ctctcggccc ggtggccgtg ttcggtgcga gcaacttccc gctggcgttc
     8581 tcggtcgcgg gcggcgacac ggcgtccgcg ctggccgccg gctgccccgt ggtggtcaag
     8641 gcccacccgg cgcacccggg cacctccgag gcggtggccc gcgccgtcac ggccgccgcc
     8701 gcgcgcaccg gcatgccggc gggcgtgttc tccctgctgg tgggccgggg ccacgacgtc
     8761 ggcctcgccc tggtcggcga tccgcggatc accgcggtgg ggttcaccgg ctcccgggcc
     8821 ggcgggctgg cgctgatcgc ggccggccgg tcgcgcccgg taccggtgcc ggtccacgcc
     8881 gagatgtccg cggtcaatcc cgtgatcatg ctcgacggtg cgctcgccga accggaaccc
     8941 gccgccgcct cgtacgtggc gtcgctgacg gccggcgcgg ggcagttctg cacgaacccc
     9001 ggcctcctgc tgctgccggc gggcccggcg ggcgacgcct ttctctccgc cgcggcccaa
     9061 gccctgaagg ccgcggaggg gcaggtcatg ctcaccccgg gcatcgcccg cgcgtactcc
     9121 gagggcgtac ggcgatggga gaacgtcccg ggcgtacggg aggtggcccg gggcgcggcc
     9181 ggggccggcc cgtacgcgcc ggcccccgtc gtcctggcgt gcgacgcggc cgtgtacacc
     9241 gcgcaccagg agctcaccgg cgaggtcttc ggcgccgccg ggctcgtcgt gcgctggtcg
     9301 gatacgggcg aactcctggg cctcctcgcg gggttggagg gccagttgac ggccacgctg
     9361 cacgcggcgg acgccgaccg ggcgacggcc ctggagctgc tgccggtact ggaggagcgg
     9421 gcgggccgcg tcctgtgggg cggctggccc accggcgtcg aggtctgcca cgcgatggtg
     9481 cacgggggcc cgtggcccgc gacgagttcg cccggcacga cgagtgtcgg caccctcgcc
     9541 gtcgaacgct ggctgcgccc ggtctgctac cagtccttcc ccgacgacct cctgcccccc
     9601 gaactccgcg acgccaaccc cctgcgggtc ccccgacaga cggggtccgg ccgcacacgg
     9661 ggagcctgaa ctccggcggc gcggggccgg ccggacggtc cgaccgcccc cgttccgtga
     9721 cccggagccg acacctccgc gccgtgaccc gaagccgacc gccccgggtc acgtaaggca
     9781 ccgaacggcg gttcccggaa cagccctcag gcccgggaag ccgtgcaccc gtacggcgaa
     9841 ggcgcatgtg cagagcggcg gtgaacccgg ccgtcaccgc cgcccgcatc ggctcggccc
     9901 gggtcatcgg gccggtccgg gcgaagcact cgtggggagg gcctggcggt tcagccatgc
     9961 ccccgacgca acgcgattat cggcctgcga tcacgcgagg cagttccacc agagtgtcgg
    10021 cgaggcggtc ggcctccagg ccgccgccct gggccagctc cggggagccg ccgccgcgtc
    10081 cgccgaggag ctgcttgacc agcgcggccg cgttcaggcc cgcctcgcgg gcggccttgt
    10141 tcagcgcgac gacgaccacg cccgtgcccg taccgatacc gacggcgccg ggcgtgccga
    10201 cgggaaggcg gtcacggacg gcggtggcca gggcccgggc ctcgtccgcg ccgcctccgg
    10261 cggtggcggt gacgacccgg acgccgtcca cgtccacgcc gccaccggcc agctcggcag
    10321 cgcgggcggc ggtcgcctgc tgcttgaggc gggcgttctc ccggtcggcc gccttgaggc
    10381 ggtcgaggag accggcgatc cgctcgggaa gttcggcgcg gggcgcgttc agctgctcgg
    10441 cgatgcgggc gacgaggtcg cgctcgcggg ccaggtagcc gaacccctcg atgccgaccg
    10501 ccgcctcgag tcggcgcatg cccgcgccga cggaggactc cgcggtgagg gcgacggtgc
    10561 cgatctgcgc ggcgtgctcg acgtgggtac cgccgcagag ctcgcgggac caggccccgc
    10621 cgatctcgac gacccggacc ttctcgccgt acgtctcgtc gaagagggcc agcgcgccca
    10681 gttccttggc ctcggggagg gtcatccacc ggacgccgac cgggaggtcg cggcgcaggg
    10741 cgcggttggc ggcctcctcc acctcggagc ggacggccgg ggagagagct ccgcgccagg
    10801 ggaagtccag gcggaggtat ccggggcggt tgtaggagcc ggactggagg gcggtcgggc
    10861 cgaggatctc ccggagggcg gcgtgcagga cgtgggtacc ggagtgggcc tggcgggccc
    10921 cgagccgcca ctcggcgtcg acggcggcgt gaacggtgtc gtccacggcc agttcgcccg
    10981 ccgtgacccg cacctggtgg gcgaccaggc cgggcagggg ccgctggacg tcgacgacct
    11041 cggcctccac cgaggccccg gcgagcaggc cggcgtcgct gtcctggccg ccggactcgg
    11101 cgtagaaggg cgtgcggtcc aggatcacgg tgacgaggtc gccggtgcgg gccaccggga
    11161 ccggcccctc ggtgccgagg agcgcgagga cgcgggactc ggtggtgagc gtggaccagg
    11221 cccgccagtc cgtcggtccg tgggagtcga gcacggtgcg gagggccgcg gtgtcggccg
    11281 ctccaccgga cttgcgggcg cgggcgtcgg cgcgggcccg ctcccgctgg gcgttcatca
    11341 gggcggtgaa gccgtcgcgg tcgacctcga caccctgctc ggcagccatc tccagggtga
    11401 ggtcgatcgg gaagccgtat gtgtcgtgga gcaggaacgc cttcgcgccg ggcagcgaac
    11461 gcccgccctc gtccttgacc ttggcgacgg cggtgtccag gacggtggtg ccctgccgga
    11521 gggtggcgcg gaaggcgtcc tcctcgccgt acgcctggtc ggaaatgcgc gcgtacgact
    11581 ccacgacctc cgggtaggag ggggccatgc agtcgcgggc gacgggcagc agctcgggga
    11641 gcgccgggtc gtggaagccg agctggcgca tggagcggac ggagcggcgc aggatccggc
    11701 gcaggacgta gccgcggccc tcgttcccgg gggcggtgcc gtcggcgagg agcatgaggg
    11761 cggtgcggac atggtcggcg acgacccgga gccgtacgtc ggactcggcg tcggccccgt
    11821 accgcacgcc cgccagctcg gcggcccggt ccaggaccgg acgcgtctcg tcgatctcgt
    11881 agaggttgtc cttgccctgc aggagggtcg ccatgcgctc caggcccatg ccggtgtcga
    11941 tgttgcggcg gggcagttcg ccgaggatcg ggtagccgga cttgccgggg ccctcgccgc
    12001 gttcgtactg catgaagacg aggttccaga actccatgta ccggtcctcg tcgaccgcgg
    12061 ggccgccctc gcggccgagg gccgggcccc ggtcgtagta cagctcggag caggggccac
    12121 aggggccggg gacgcccatg gaccagaagt tgtcctcgtc gccgcgctcc acgatccgct
    12181 cgtcgggcag cccggcgacc gcgcgccaga tgccgcggga ctcggtgtcg gagtggtgga
    12241 ccgtcaccca gatccgctcc gggtcgaggc cgtaaccgcc gtccgcctgc ggcttcgtgg
    12301 acaggtccca ggcgaaggcg atggcctctt ccttgaagta gtccccgaag gagaagttgc
    12361 cgttcatctg gaagaacgag ccgtgccggg tggtcttgcc gacctcctcg atgtccaggg
    12421 tccgcacgca cttctgcacg ctggtggccc gctgccacaa gggggtggcc tcgccggtga
    12481 agtacggctg gaacggcacc atccccgcgt tgacgaacag cagcgtcgga tcgggcgtgg
    12541 gcagtggggc gctggggacg acggtgtggc cgcgggcggc gaagtggtcg aggaagcgct
    12601 ggcggatgtc ggcggtacgc aagggtctca ctgctccggt cgaaggatct cggggccctg
    12661 gggctccagg gcggggagcc gaacgcgtcc gcgtacacga cacgtcagcc gtccgtggac
    12721 gcgggcaggc aggcggcgcc cggaaccgag gtgggcgagg gcggtcatca ggcggctctc
    12781 accgaggacg cgggcagcgg ggtcagggag gcgtactcca gcggcgccga cggatcgatc
    12841 gacacctcca gcg
//
