LOCUS       NZ_CP015883            22982 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Enterococcus faecalis strain sorialis chromosome, complete genome.
ACCESSION   NZ_CP015883
VERSION     NZ_CP015883.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2873100)
  AUTHORS   Fouts,D., Sanka,R., Singh,I., Gill,J., Llorente,C. and Schnabl,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2016) JCVI, 9714 Medical Center Drive, Rockville,
            MD 20850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Assembly Name :: HGAP assembly of Enterococcus faecalis sorialis
            Expected Final Version            :: Yes
            Genome Coverage                   :: 10.44x
            Sequencing Technology             :: Pacbio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 02:48:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,936
            CDSs (total)                      :: 2,860
            Genes (coding)                    :: 2,801
            CDSs (with protein)               :: 2,801
            Genes (RNA)                       :: 76
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 35 of 59
            Pseudo Genes (incomplete)         :: 26 of 59
            Pseudo Genes (internal stop)      :: 18 of 59
            Pseudo Genes (multiple problems)  :: 14 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:14:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 200140
            Orig. end                         :: 223122
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015883.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22982
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22982
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22982
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12982](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12982)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(36..51)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.83"
                     /tool="antismash"
     gene            complement(1081..1536)
                     /gene="tnpA"
                     /locus_tag="A6B47_RS00830"
                     /old_locus_tag="A6B47_00795"
     CDS             complement(1081..1536)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002301718.1"
                     /locus_tag="A6B47_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00795"
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_087548478.1"
                     /transl_table=11
                     /translation="MSNDDKSLAHTRWNCKYHLVFTPKYRGKVIYGQLRRDIGKILRKL
                     CEMKEVEIIEAHAMPDHIHMLVRIPPKLSVSSFMGFLKGRSAVNIHERHTNLKYNYGNR
                     FFWSKGYYVSTVGLNQKTIAKYIREQEAEAQVKDSINKREYKDPFRK"
     gene            complement(<1710..>2585)
                     /locus_tag="A6B47_RS15560"
                     /pseudo=""
     CDS             complement(<1710..2585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340466.1"
                     /locus_tag="A6B47_RS15560"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKDKLNILEMKRKHLFLILAKQPFLLKQTWSMPIIISLKK"
     gene            complement(2629..2793)
                     /locus_tag="A6B47_RS00840"
                     /old_locus_tag="A6B47_00800"
     CDS             complement(2629..2793)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6B47_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6B47_00800"
                     /product="hypothetical protein"
                     /protein_id="WP_231399931.1"
                     /transl_table=11
                     /translation="MTDKLKDKAKEAAGDVTNDKETKTEVDQAVGKVKEITSDVKKGRS
                     SQRCKRKTR"
     gene            complement(<4588..>4969)
                     /locus_tag="A6B47_RS15565"
                     /pseudo=""
     CDS             complement(<4588..4969)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383787.1"
                     /locus_tag="A6B47_RS15565"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSIWPIMNYIRGKSVNWLSLIVLLIFLIYATNQKQMIVIMLVFLV
                     VLAGILYLSTQNILMTLPHILL"
     CDS             complement(5138..5308)
                     /gene="allorf_0205278_0205448"
                     /locus_tag="allorf_0205278_0205448"
                     /protein_id="allorf_0205278_0205448"
                     /tool="antismash"
                     /transl_table=1
                     /translation="METAHLKIHFVKGLSNSFGKNKNKNSTIKFVTASINNGCMWNTVF
                     RNIYRCLTPYK"
     CDS_motif       complement(5249..5308)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: METAHLKIHFVKGLSNSFGK"
                     /locus_tag="allorf_0205278_0205448_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5138..5248)
                     /prepeptide="core"
                     /locus_tag="allorf_0205278_0205448_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="4132.8"
                     /monoisotopic_mass="4130.1"
                     /core_sequence="NKNKNSTIKFVTASINNGCMWNTVFRNIYRCLTPYK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="METAHLKIHFVKGLSNSFGK"
                     /leader_location="[5248:5308](-)"
                     /alternative_weights="4150.8"
                     /alternative_weights="4168.8"
                     /alternative_weights="4186.8"
                     /alternative_weights="4204.8"
     gene            complement(5626..6609)
                     /locus_tag="A6B47_RS15570"
                     /old_locus_tag="A6B47_00810"
     CDS             complement(5626..6609)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358185.1"
                     /locus_tag="A6B47_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00810"
                     /product="site-2 protease family protein"
                     /protein_id="WP_087548480.1"
                     /transl_table=11
                     /translation="MKFISPMIFTLLLEIFTLVFELNLVSIAYFALLLSIFVHELGHLA
                     FGLFNKVRPESLIFGFIKLSWENQFKVRLNTQWGFFGGLFRYKPTTFNNKKILRLLTGG
                     PIFSLFFTLTFFIKIDFFQYFSLFNFSIFLITVVPFNFNGFMNDGYNIYKLVTKDYIFE
                     MYYIVSNSLLNKYNQSTFLNTNEVCKIIKKNKELPLYVLNTFLLYVIYEYLIDKNNRKL
                     KLIYPILSKEDKILNNKSYLQNFYLANLYMIEYILSVDNKQTFKKINLKILDSISRSRI
                     KYLNFKCSKSADDEISQSMTEFSNIIKNYPDQTSTMIIAEKRWVQN"
     gene            complement(6610..7848)
                     /locus_tag="A6B47_RS00860"
                     /old_locus_tag="A6B47_00815"
     CDS             complement(6610..7848)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358184.1"
                     /locus_tag="A6B47_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00815"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_087548481.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.3e-36, bitscore:
                     121.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRGLTYILISYIFFTLGTTGYASDLSNNISFFIDNSQTTAIEE
                     IESELSSEKVDYIQEIGLVSFKNLDDSDRKFIGKYFNVSEGKKLPDFKPEEVNSSILNI
                     NILNKDFKSFNWPYKKILSHIDPVKEQLGKDITIALIDSGIDRLHPNLQDNNLRLKNYV
                     NDIELDEYGHGTQVAGVIDTIAPRVNLNSYKVMDGTDGNSINMLKAIVDATNDQVDIIN
                     VSLGSYKNMEIDDERFTVEAFRKVVNYARKNNILIVASAGNESRDISTGNEKHIPGGLE
                     SVITVGATKKNGDIADYSNYGANVSIYGPAGGYGDNYKITGQIDAREMMMTYYPTSLVS
                     PLGKAADFPDGYTLSFGTSLATPEVSAALAAIMSKNVDNSKDSNEVLNTLFENADSFID
                     KNSMLKYKEVRIK"
     gene            complement(7845..9989)
                     /locus_tag="A6B47_RS00865"
                     /old_locus_tag="A6B47_00820"
     CDS             complement(7845..9989)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002415198.1"
                     /locus_tag="A6B47_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00820"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_087548482.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.5e-41, bitscore:
                     137.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKYVAQGEHSECALACITMLLNYYGNQSTLVELREKYGVPKG
                     GLTIKNIRTVFDEYGFDVSTFKSSFSNYLDLPTPVISYWNNQHFVIIEKIKKKKVLILD
                     PASNKRWIDISEFKKNFSNILIYAHKKKTKKEGKRKQFFLKSFIFTKFKRYFFSLIILS
                     FVSQLLLLLIPIATKYSIDNIRSFQEIPTYILLLILTSFFSVLYVVQYLKSSVVAEFQY
                     EFDFKLMFSYIDKLFSMPLMYFSNRSTGELVFRANLNIYIRQILSQKVITTLIDSLFLG
                     IYLFLMVNYSILLTIIALVLISLIAFLSIINSHTIKRFVDKEIMEQGNVQRIITEAIEG
                     IETIKSANAEKSFLLNWKNMFTSQLLITKNKNRYIAIFGILPEIIQSVMPALFLIIGIK
                     LIINNSLSLGSLIGFVSIVTMVMKPILSLVSSYNDFLLLNVYFQKLSEVLTYEEKNNFN
                     NKIGNAGKEEFIYRLNNVYYTISVFEKNILNGISFDIRKGDKVAIVGRSGSGKSTLLKL
                     LSGLLQPSNGEILYEGYPLSNNSNNRRNIFYVNQNAHIFNETIEKNISLEFKPNSSINE
                     KKRLKESMNKSKMDEVLLGIPQHEKTIVSENGNNFSGGQRQKIALARAFYSNVNTLLLD
                     EPTSAMDNISEFEVFSNLLDEKRTVITVAHRISTVKNFDKIILMDNGEIVCIGKHEDLI
                     ENSELYRSLYYKKQQFGGTK"
     gene            complement(10001..12982)
                     /locus_tag="A6B47_RS00870"
                     /old_locus_tag="A6B47_00825"
     CDS             complement(10001..12982)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368286.1"
                     /locus_tag="A6B47_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00825"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_087548483.1"
                     /sec_met_domain="DUF4135 (E-value: 2.8e-93, bitscore:
                     310.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.3e-50, bitscore:
                     166.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDNLINVLSINERCFLLKQSGNEKYDIKNLQAWKERKSVLKQDD
                     LDYLIKYKYESLDNFGLGITPIENFPDKEVAIQYIKDQSWYIFFESILDSYNDSEEQLL
                     EVDASYPFRYFLQYARLFLLDLNSELNICTKEFIINLLETLTQELIHLTSKTLVLDLHT
                     FKKNEPLKGNDSSKRFIYYLKKRFNSKKDIIAFYTCYPELMRITVVRMRYFLDNTKQML
                     IRVTEDLPSIQNCFNIQSSELNSISESQGDSHSRGNTVSTLTFSDGKKIVYKPKINSEN
                     KLSDLFEFLNKELEADIYIVKKVTRNTYFYEEYIDNIEINNTEEVKKYYERYGKLIGIA
                     FLFNVTDLHYENIIAHGEYPVIIDNETFFQQNIPIEFGNSATVDAKYKYLDSIMVTGLV
                     PYLAMKDKSDSKDEGVNLSALNFKEQSVPFKILKIKNTFTDEMRFEYQTHIMDTAKNTP
                     IMNNEKISFISYEKYIVTGMKSILMKAKDSKKKILAYINNNLQNLIVRNVIRPTQRYAD
                     MLEFSYHPNCFSNAIEREKVLHNMWAYPYKNKKVVHYEFSDLIDGDIPIFYNNISKTSL
                     IASDGCLVEDFYQESALNRCLNKINDLCDEDISIQTVWLEIALNIYNPYKYINDLKNQN
                     SNKYIYTGSELNSKIIQACQKIEKKIFKRAIFNKKTNTVNWIDIKLDQDWNVGILNNNM
                     YDGLPGIFVFYVALKYITKNHKYDYVIECIKNSIYTIPSEDILSAFFGKGSLIYPLLVD
                     YRLNNDINSLNVAVEIADMLIEKKSINNGELKNDWIHGHNSIIKVLLLLSEITEDEKYR
                     KFSLEIFEKLSEEPYFNFRGFGHGIYSYVHLLSKFNRIDKANSLLHKIKESYFEEEPKN
                     NSWCKGTVGELLATIELYDDNISNIDINKTMAYKNKDCLCHGNAGTLEGLIQLAKKDPE
                     TYQYKKNKLISYMLNDFEKNNTLKVAGSEYLESLGFFVGISGVGYELLRNLDSEIPNAL
                     LFEL"
     gene            complement(13043..13234)
                     /gene="cylL-S"
                     /locus_tag="A6B47_RS00875"
                     /old_locus_tag="A6B47_00830"
     CDS             complement(13043..13234)
                     /codon_start=1
                     /gene="cylL-S"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358181.1"
                     /locus_tag="A6B47_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00830"
                     /product="lanthipeptide cytolysin subunit CylL-S"
                     /protein_id="WP_002358181.1"
                     /transl_table=11
                     /translation="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGSGDVQAETTP
                     ACFTIGLGVGALFSAKFC"
     CDS_motif       complement(13127..13234)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /locus_tag="A6B47_RS00875_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13043..13126)
                     /prepeptide="core"
                     /locus_tag="A6B47_RS00875_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="2632.0"
                     /monoisotopic_mass="2630.3"
                     /core_sequence="GDVQAETTPACFTIGLGVGALFSAKFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /leader_location="[13126:13234](-)"
                     /alternative_weights="2650.0"
                     /alternative_weights="2668.0"
     gene            complement(13268..13474)
                     /gene="cylL-L"
                     /locus_tag="A6B47_RS00880"
                     /old_locus_tag="A6B47_00835"
     CDS             complement(13268..13474)
                     /codon_start=1
                     /gene="cylL-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358485.1"
                     /locus_tag="A6B47_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00835"
                     /product="lanthipeptide cytolysin subunit CylL-L"
                     /protein_id="WP_002358179.1"
                     /transl_table=11
                     /translation="MENLNVVPSFEELSVEEMEAIQGSGDVQAETTPVCAVAATAAASS
                     AACGWVGGGIFTGVTVVVSLKHC"
     CDS_motif       complement(13403..13474)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENLNVVPSFEELSVEEMEAIQGS"
                     /locus_tag="A6B47_RS00880_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13268..13402)
                     /prepeptide="core"
                     /locus_tag="A6B47_RS00880_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="4019.5"
                     /monoisotopic_mass="4017.0"
                     /core_sequence="GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKH
                     C"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENLNVVPSFEELSVEEMEAIQGS"
                     /leader_location="[13402:13474](-)"
                     /alternative_weights="4037.6"
                     /alternative_weights="4055.6"
                     /alternative_weights="4073.6"
                     /alternative_weights="4091.6"
                     /alternative_weights="4109.6"
     misc_feature    13877..13892
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.29"
                     /tool="antismash"
     gene            13878..14078
                     /gene="cylR2"
                     /locus_tag="A6B47_RS00890"
                     /old_locus_tag="A6B47_00845"
     CDS             13878..14078
                     /codon_start=1
                     /gene="cylR2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002370931.1"
                     /locus_tag="A6B47_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00845"
                     /product="cytolysin regulator CylR2"
                     /protein_id="WP_002358483.1"
                     /transl_table=11
                     /translation="MIINNLKLIREKKKISQSELAALLEVSRQTINGIEKNKYNPSLQL
                     ALKIAYYLNTPLEDIFQWQPE"
     gene            complement(14546..15858)
                     /locus_tag="A6B47_RS00895"
                     /old_locus_tag="A6B47_00850"
                     /pseudo=""
     CDS             complement(14546..15858)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383787.1"
                     /locus_tag="A6B47_RS00895"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A6B47_00850"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEDRSDIVTNKVEKIDILILSSFVFVVMLIYNFGIEQMEFGDDAF
                     FLKQFTHDFQSNYYEFLKFRYNEWTSRLVIEIALTQAVQHVFLWRILNAIAMSIVAIVP
                     ALLFNADNSRSGLIIGTGMSLLIPASMINNAGWIATTTNYVWVMAAALLSIWPIMNYIR
                     GKSVNWLSFILSLVFLIYATNQEQMVVIMLVSLLVLAGILYLSKMNILITLPHIAIVIA
                     SFVFILTCKGNAARNVQETKQWLPNFSSYSIFDKLQIGYSSTLKALFFEWSPLMLAFVL
                     LILTAGLVKNGTLVKKMISGIPLLTYLICTRFNTIINQTYDIASGKTYMSLVVLLTGLV
                     FFM"
     gene            complement(15848..15979)
                     /locus_tag="A6B47_RS15755"
     CDS             complement(15848..15979)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159353.1"
                     /locus_tag="A6B47_RS15755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002368288.1"
                     /transl_table=11
                     /translation="MTKEEKILLIVRNSDFTYEELEKLPMSSIDSIYRAHVLEKNGG"
     misc_feature    complement(16314..16323)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.05"
                     /tool="antismash"
     misc_feature    complement(16323..16342)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            complement(16542..17675)
                     /locus_tag="A6B47_RS00900"
                     /old_locus_tag="A6B47_00855"
     CDS             complement(16542..17675)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012372.4"
                     /locus_tag="A6B47_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00855"
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_231399933.1"
                     /transl_table=11
                     /translation="MCWLSPDCKHFSKAKGGTPVNKKIRGLAWIAVRWTATVKPRVIIL
                     ENVEEFKTWGPLIVTKDGPKPDPKKKGKTFQSFVRALERQDYHVEFKELRACDYGAPTT
                     RKRLFMIARRDHKPIVWPTPTHGSRESKEVAEGKYLPYQSAASCIDWSIPDNSIFGRKK
                     PLRPNTLKRIARGLNKFVLNTVDPYIVRIDQTSYGKVKRTNSIKEPLTTSTNKAEQLLL
                     SPIIGVNTTGHSGTKISAPLATITTSGHHMLISSFLAKNYGSDIGQHLNEPLHTIPTKD
                     RFGLVKVKGSAYRIVDITMRMLQPHELAKAQGVPDTYVLDKGKNGKKISKAKQVARIGN
                     MVVPNCAEALVRANLPELCCNQPFNEQVELLNEDFSW"
     gene            complement(17678..17884)
                     /locus_tag="A6B47_RS15575"
     CDS             complement(17678..17884)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6B47_RS15575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_231399935.1"
                     /transl_table=11
                     /translation="MKEIVVDNFAGGGGASTGTEHAIGRSVDVAINHDPDAIAMHEANH
                     PNTKHYCESVWESTREMLPMDGQ"
     CDS_motif       complement(17849..17884)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKEIVVDNFAGG"
                     /locus_tag="A6B47_RS15575_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17678..17848)
                     /prepeptide="core"
                     /locus_tag="A6B47_RS15575_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.80"
                     /molecular_weight="5928.4"
                     /monoisotopic_mass="5924.7"
                     /core_sequence="GGASTGTEHAIGRSVDVAINHDPDAIAMHEANHPNTKHYCESV
                     WESTREMLPMDGQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKEIVVDNFAGG"
                     /leader_location="[17848:17884](-)"
                     /alternative_weights="5946.4"
                     /alternative_weights="5964.4"
                     /alternative_weights="5982.4"
                     /alternative_weights="6000.5"
                     /alternative_weights="6018.5"
                     /alternative_weights="6036.5"
                     /alternative_weights="6054.5"
     gene            complement(18183..18419)
                     /locus_tag="A6B47_RS00905"
                     /old_locus_tag="A6B47_00860"
     CDS             complement(18183..18419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002393723.1"
                     /locus_tag="A6B47_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00860"
                     /product="hypothetical protein"
                     /protein_id="WP_087548484.1"
                     /transl_table=11
                     /translation="MGCKKNFVIKVSQNFGGGVEQWYYYSGTTYTVQGEVFGNFVDDIR
                     NAKDYTSKKRAENAMEKLKIKVGNWSNMMVIQK"
     gene            complement(18614..19167)
                     /locus_tag="A6B47_RS00910"
                     /old_locus_tag="A6B47_00865"
                     /pseudo=""
     CDS             complement(18614..19167)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402121.1"
                     /locus_tag="A6B47_RS00910"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00865"
                     /product="thermonuclease family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSHSLLLSGCTNVEQKAQDFVQDLEQDVYEGFFQTISNDQRIPAD
                     FVRHVDGDTTVLKIEDKEQKVRFLLIDTRRPSNQTQKFSRLA"
     gene            19359..19814
                     /gene="tnpA"
                     /locus_tag="A6B47_RS00915"
                     /old_locus_tag="A6B47_00870"
     CDS             19359..19814
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002301718.1"
                     /locus_tag="A6B47_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00870"
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_087548485.1"
                     /transl_table=11
                     /translation="MSNDDKSLAHTRWNCKYHLVFTPKYRRKVIYDQLRQDIGKILRKL
                     CEMKEVEIIEAHAMLDHIHMLVRIPPKLSVSGFMGLLKGRSAVIIHERHANLKYNYGNR
                     SFWSKGYYVSTVGLNQKTIAKYIREQEAEDRVRDSINKIEYRDPFSK"
     gene            complement(20001..20153)
                     /locus_tag="A6B47_RS00920"
                     /old_locus_tag="A6B47_00875"
     CDS             complement(20001..20153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401712.1"
                     /locus_tag="A6B47_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00875"
                     /product="hypothetical protein"
                     /protein_id="WP_087548486.1"
                     /transl_table=11
                     /translation="MGNENLQKIYADSTKKRTAQQTEWEQAVEGLTFDRLEKKKIEYSL
                     KRKKS"
     gene            complement(20167..20619)
                     /gene="ssb"
                     /locus_tag="A6B47_RS00925"
                     /old_locus_tag="A6B47_00880"
     CDS             complement(20167..20619)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ssb"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365876.1"
                     /locus_tag="A6B47_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00880"
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_087548487.1"
                     /transl_table=11
                     /translation="MINNVTLVGRLTKDCDLRYTSSGVAVAAFTLAVNRNFTNQNGERE
                     ADYIQCVIWRKPAEALANYTRKGTLIGLVGRLQTRNYENQQGQRIYVTEMVVESFQLLE
                     SKEVSQQRGVNASNPTPVGQQESNTQQPFPDLEGSSIEISDRDLPF"
     gene            complement(20685..20855)
                     /locus_tag="A6B47_RS00930"
                     /old_locus_tag="A6B47_00885"
     CDS             complement(20685..20855)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6B47_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6B47_00885"
                     /product="hypothetical protein"
                     /protein_id="WP_231399939.1"
                     /transl_table=11
                     /translation="MLYLFYISPYEEDWEMDHQSIVENYQYTYGLNETYPFLSEFGEIK
                     FKNMFGGLVKQ"
     CDS             complement(20881..20943)
                     /gene="allorf_0221021_0221083"
                     /locus_tag="allorf_0221021_0221083"
                     /protein_id="allorf_0221021_0221083"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRLMGIHEATIAQYTCILCD"
     CDS_motif       complement(20917..20943)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRLMGIHEA"
                     /locus_tag="allorf_0221021_0221083_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(20881..20916)
                     /prepeptide="core"
                     /locus_tag="allorf_0221021_0221083_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="1207.4"
                     /monoisotopic_mass="1206.6"
                     /core_sequence="TIAQYTCILCD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRLMGIHEA"
                     /leader_location="[20916:20943](-)"
     gene            21107..21361
                     /locus_tag="A6B47_RS00935"
                     /old_locus_tag="A6B47_00890"
     CDS             21107..21361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016614799.1"
                     /locus_tag="A6B47_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00890"
                     /product="hypothetical protein"
                     /protein_id="WP_087548488.1"
                     /transl_table=11
                     /translation="MNQLEFNELLDKNPQFLKAYLQENLLTKDEAPKYTKQTQAGFDQS
                     AKIGTTIQPFFSKQKNGRTTFKLYLKSEMIEYGKNKRNK"
     gene            complement(21502..21678)
                     /locus_tag="A6B47_RS00940"
                     /old_locus_tag="A6B47_00895"
     CDS             complement(21502..21678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016626329.1"
                     /locus_tag="A6B47_RS00940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00895"
                     /product="putative holin-like toxin"
                     /protein_id="WP_087548489.1"
                     /transl_table=11
                     /translation="MKVSTKIYERRSLLSIAEALALMISFGSLIASLIFGILSAVNNDK
                     KSNRSYLWLDNGY"
     gene            21826..22011
                     /locus_tag="A6B47_RS00945"
                     /old_locus_tag="A6B47_00900"
     CDS             21826..22011
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6B47_RS00945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6B47_00900"
                     /product="hypothetical protein"
                     /protein_id="WP_231399954.1"
                     /transl_table=11
                     /translation="MDTKTLEHYQKWCQENLLNRTEAMTITKQSKTAFAQSVYTKQLVP
                     FIEKKVTSHPELFVYF"
     misc_feature    complement(21852..21865)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.62"
                     /tool="antismash"
     gene            complement(22104..22229)
                     /locus_tag="A6B47_RS15760"
     CDS             complement(22104..22229)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6B47_RS15760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255321397.1"
                     /transl_table=11
                     /translation="MKKALQIKLNQEIQISLEQDKSKSTRKEQLIEQIDQVEIGY"
     gene            complement(22362..22973)
                     /locus_tag="A6B47_RS00950"
                     /old_locus_tag="A6B47_00905"
     CDS             complement(22362..22973)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016622192.1"
                     /locus_tag="A6B47_RS00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6B47_00905"
                     /product="hypothetical protein"
                     /protein_id="WP_231399956.1"
                     /transl_table=11
                     /translation="MTENNSRFDFSDFYEEGFEKTESFEQAIYVFQDGTLWSGYSEDGD
                     GYTRDVDHGSIEAFFKDISIDRYHPDFHSLKLEELIQIVPETRTVLTVMDNHYSQEQVE
                     VLKQLEEENFIIEQLENTLQVGTEKLNSEEYQEGGFEEQNSESYLYDIDIVEENEEIVQ
                     AYNHFLKNIEVDSLSKNNNQYKTKNKINENEQFNGISHDI"
ORIGIN
        1 tatcatttta ttacagatgg tattcctctt catccagggc caaatggtca agtgatgtta
       61 actaaacttt ttattgaatc actcggacta aaacagtatg gaggttatat tgaatcatta
      121 gattatgaat tgggatatgg aaaacaagac cttgaaatag aagcaccggt attttttgat
      181 atagataata acgtcgtttc gttagataaa gataaattga gagaattagt aaatgatgaa
      241 ttaagtgatg taacgttaat tgctaaggaa aaaaatacaa ataaggagta ttctatttgt
      301 gatgataaaa gaatgctttt attgggaggt ttagatgaaa ataaagagta tgagatttat
      361 ctttctgcta aaagtagcaa aaaaccaatt atatataatt gggaaaagca tgatttgata
      421 gttggggata ttacaaggaa tttatcaatt aagcatactg gaggttatgt gagtcgatat
      481 acaattactt gggaagaacc atatgaatca agttcaggag agattatcaa agaaaaaaaa
      541 caatggacag gaaatggtaa ggatatttta ctggggaatg tttcaaatat tgatatttca
      601 tcaaaagccc ggaacattca aatcaaaatc gaagaatgta caggtttggt atctgagtgg
      661 tggaaaacta tttttgataa agaatattca ctgttagatg atgacataac tattaatatt
      721 ggtggcacaa cattacaccc gaaagtaata gtaaataatc attgattctt tactattaaa
      781 aaattgctta caatagctaa taaaagaact atatgtagca aaaattattc aactgactat
      841 tttataatat agagataaaa ggaacggtta attcttattt ataaaaatag attctccatt
      901 aaatcgtgtt ggtgaagaca aatttgaata aaacttagtt gatatgcggt gcgttctgtg
      961 cgcccgcata ttttttgatt tttaaagatt atcccttgtt gtaaataaat gcgtgctctg
     1021 aaatcgtaaa aattacgctc taaaaaagcc acccgctacc tttctattct tatctagttg
     1081 ttacttccta aatggatctt tatactctct tttgtttata ctatccttta cttgagcttc
     1141 tgcttcttgt tctcgtatat acttagctat cgttttttgg ttcagtccta cagtgcttac
     1201 ataatagcct tttgaccaaa agaatcgatt tccataattg tattttaaat ttgtatgacg
     1261 ttcatgaatg tttactgcac ttcttccttt taagaaaccc ataaaacttg atacactcaa
     1321 ctttggtgga attcttacca acatatggat atgatcgggc attgcatgcg cttcaatgat
     1381 ttcgacttct ttcatctcac acaattttct tagtattttc cctatatctc gcctcaattg
     1441 accatatatt acttttcctc tatattttgg tgtaaacaca agatgatact tacaattcca
     1501 acgagtatgt gctaaacttt tatcgtcgtt cgacattcaa aatccccttt cgatttgata
     1561 acggttggta gcctttatct attatatcga aaggagtttt tatcgctaaa gctctgactt
     1621 ccacgtgcag tacgcgtgtt tttttgtcga aatctcttta gagatttcaa ctgactaaag
     1681 tcattaatca aaagcgattt gtttaatcaa tatgggattt taaaggcatt ttgaatgcca
     1741 gaacgataac aagagaagat cttggatttt tttctaaaag cttgagggaa gacaggatat
     1801 atgtttttta gagtttcgtg aaagctttcg taattctttg gtatagatta ggagtttgta
     1861 gatgatcgta tgactgcttt ctttttttag ccgatgatgc tgtcgtttga gtgattctag
     1921 tttgtctgaa tttttgagta ttagcttcca atagcatttc agtttcaggt atttttttaa
     1981 tcttcggaac tataagcgtg aaagcgattt atgatttgaa cacggaattg attaaagcta
     2041 cgactgatgt gttacacaat attggaacca atctgtgaag atttctgcgt tgggaaatcc
     2101 ttttttcaac agttggttat agctggcatt catatccatc acaaggtatt tcacgttcaa
     2161 ttgtgttttt ctaggaaagc gtataaagta ttgtgcgagt ttgaataatc gctgatcttc
     2221 aaaaatcgtg aacagcatat tggtttatca catccacgaa aataaaactc atggctccag
     2281 cgatggattt catggattta aatttgttca tgcataaaca gaaggcaaat atttttaatt
     2341 cgtttggtaa tccttgggcg cttcgcataa gatacttgag attgttccat ccgaaataaa
     2401 ggactttttt gcgatcaatt tttgtgattg gttttcaaac agattcatga gtatcgcctg
     2461 tttcatttct ttagtgagat gataatgggc attgaccaag tttgtttgag tagaaaaggt
     2521 tgtttcgcaa gtatgagaaa gaggtgtttg cgtttcatct ctagaatatt cagcttgtct
     2581 ttgataattt gagcttgaaa atttttctac tttatagaca cttatttttt atctagtttt
     2641 tcttttacat ctttgactac ttcttccttt ttttacgtca gaggtaatct ctttgacttt
     2701 accaacagct tgatcaactt cagtttttgt ttctttatcg tttgtaacgt caccagcagc
     2761 ttcttttgct ttgtctttga gtttatctgt catttaaacc accttcttaa aaagaataat
     2821 ggtccttgta gggtctgaac ctgcgactgg atgggtatga gccgtctgtt ctaaccaatt
     2881 gagctaaaag tcttttattt taataaaact atatattact tgaaaaaacg aactggtaat
     2941 tataaaatat aattaggaac tgaaagtgtc actcctaaaa aaagggtaat agtttttatg
     3001 agcttgggga agtcttttat aaaaaactct tactcttttt atttttaatc atatcatact
     3061 attataaata attaagctgt ataaatgttt gattggtagt attttttaat tgatttatac
     3121 ttaatacttt ttattgaaaa aaagtgatgt ttgttataga atatagtcac cagtaggaca
     3181 ataatggatt attcagcttg cttatatttt ttagtggtgt ccttttttgg aggaatgtta
     3241 cgcttttatt gtatgttaga tttttaagtg aaataatcta tgatattaat tataaaatgt
     3301 aatcaatttg tgtttaaact ttgagagtgt aatccaaata ttttgtagag taagaagatt
     3361 ttagaaccta tatgtttgtt tttcatgatc aaaagggcta atagaatggg ttttctatcg
     3421 gttctttgtc aaataatgtt ggtaaagaga aattgtagaa tcgcgtcaag tccagaggag
     3481 aaaatcctct ggatttttta ttttgtcttg cttgtcctaa acgaaaatca taagtatttc
     3541 gctttagcac tttgatagga ttatttagat actccaactg tccactcgaa taagaataat
     3601 tcaatgcatg atgagtttat ttttggtatt tgttaaaggt tcgtaaggtg atttgataag
     3661 tagcagacaa gtgagatact ttgtgtaagt aagacattaa aatacgtttg ggttcgttta
     3721 tgaatagcat acaaaaagtc ttagtataac gaggagtttt atgttaactc aatactaaat
     3781 actataggaa agtagtctgt tcacaagctt tgtttcggtt aaataagttt taaacgaagg
     3841 gcgtcaacgt tggcttaaac tagcttgatt ttttgtaata gctttcaata ctttttaagt
     3901 tgcttacttt gttggttttc agccaaactt gaacttttta ataggcagtt tgtccaagtg
     3961 attcgatggt ttcgaaaggt tcgaccaaga tgataaacga tgagcttagc gttaggtcaa
     4021 catttcttca ctagacaaac ataaggtgcg tacatatcaa tggcaataaa ttggacgttt
     4081 tcccacacag acagtggaaa ataatgtttt aaatgtggat aaaggctctg acctgacact
     4141 aagaataatt ataaccaact atcaagtctg tataaaggtg aatactttat accgttaaat
     4201 aagtgtggct tctataacac ataaagaatt acttaaaggg aattttttat gttactctga
     4261 gcatagtgac ggtaagtttt ctgaaaagga tgtacagaat gtgaatgtta caatgtccgg
     4321 ttcaaaaatg ctggacagga gcgtatattt tttatccaca ttttctttca attgctatct
     4381 ctgctattaa cgtaaataaa cagtccgttt tactacaaat taaaaatatt aaaatgtatt
     4441 ggctaactaa cctaataaat atctaaaatt ttttgtagtt ttcactacag tatgccgaaa
     4501 tatgacataa tttcactgta gtagacttat ggttttaaag agtaagaggg ggaaatggaa
     4561 aaccggatta ctgatattaa aaaaaattag tgtcaaaata acaacccata ataacaggat
     4621 ggagaccact caaaaaaagc tttcaaagtg aacgaatacc ttatttgaaa cttatcaaaa
     4681 atattgtagt tagaaaaatt aggtagccat tatttcgttt tttgccacat ccccttatat
     4741 attaaaataa acacaaagtt aacgattata ataaaatatg aggtaaagtc atcaggatat
     4801 tttgagtaga cagatataga atacctgcca aaactactaa aaaaactaac ataattacta
     4861 tcatttgttt ttggtttgta gcataaatca agaatatcaa caatacaatt aaggatagcc
     4921 aatttacact ttttcctctt atatagttca taataggcca aatacttaga aatttctgac
     4981 ctgttttttt aggtaaaaat tacacaaact agcttgtgcc ttattcataa catagtattt
     5041 tattgcaaat ccaaagagcc gaatttttag tttcggctct tttttggatc tatttttctt
     5101 taactacttt gggacaagtt tgatccgtaa gggcgaatta tttataggga gttaaacacc
     5161 tataaatatt acgaaagacg gtgttccaca tgcatccatt attaattgaa gcagttacaa
     5221 atttaattgt tgagttctta ttcttgtttt tcccaaaaga gttcgataat cctttaacaa
     5281 aatggatttt caaatgggct gtttccaatt tgttaaagct aattttttac tacgtgaaaa
     5341 gaaaactgga ggaacacaga ttaaaatagc caacaacagg aaaaagggta taatttcctc
     5401 ttttctgttg aagtatgccc aacttgaatg tcctgctacg tatctaataa caatttgaac
     5461 atagaaaaga accaacaagg tataccctgt tgattctttt agttaatata ttttaataga
     5521 aaatttattt attacatcat gaaatactgt ataaaaatcg tagcaagcac acatcacttt
     5581 ttttagccta tcattttacg ttgacagtct agctggtttc ttatctcaat tttgaaccca
     5641 tcgtttttct gctataatca tagttgacgt ttgatctgga taatttttaa tgatattgct
     5701 aaattctgtc attgattgac ttatttcatc atcagcactt tttgagcatt taaaatttag
     5761 atatttaatt ctagatctac taattgagtc tagaattttt aaattaattt ttttaaaagt
     5821 ttgtttatta tctacagata agatatattc tatcatatac aaattagcta aataaaaatt
     5881 ctgtaaataa cttttattat tcagtatctt gtcttcttta ctaagtattg ggtatattag
     5941 ttttaatttc ctattatttt tgtctattaa atactcatat ataacataca gtaagaatgt
     6001 atttagcaca tataatggta attctttatt tttttttatt attttgcata cctcattggt
     6061 atttaagaaa gttgactgat tatatttatt aagtaagcta tttgatacaa tataatacat
     6121 ttcgaaaata taatccttag taactaattt atatatattg tatccatcat tcataaaccc
     6181 gttaaaatta aaaggaacta cagtaatcaa gaatattgaa aaattaaata aagaaaaata
     6241 ttgaaaaaag tcaattttta taaaaaaggt taatgtaaaa aaaagactaa atattggtcc
     6301 tccggttaac aacctcagaa ttttcttatt attaaacgta gttggcttat atctaaataa
     6361 tccaccaaaa aatccccact gtgtatttaa tctaacctta aattgatttt cccacgaaag
     6421 ttttataaaa ccaaatatta atgactctgg tctaacttta ttaaataatc caaaagctaa
     6481 atgacctaac tcatgtacaa agatagacaa taacaaggca aagtatgcta tagacactaa
     6541 atttaattca aaaacaagag taaagatttc gagaagtaac gtaaagatca tcggagatat
     6601 aaatttcatc tattttattc tcacctcttt gtatttaagc atgctatttt tatctataaa
     6661 agaatcagca ttttcaaata aagtatttaa tacttcattt gaatctttag aattatctac
     6721 attctttgac ataatagctg ctaaagctgc gcttacttct ggagttgcta aacttgttcc
     6781 aaaagaaagt gtataaccat ctggaaagtc agcagctttg cctagtggag aaactagcga
     6841 tgtagggtaa taagtcatca tcatttcacg agcatcaatt tgtcctgtta ttttgtaatt
     6901 gtcaccatat cctcccgcag gaccatatat agaaacatta gccccataat tagaatagtc
     6961 agcaatatca ccattctttt ttgtagctcc gacggtaatt acagactcta gtcctcctgg
     7021 tatatgtttt tcattaccag tgcttatatc ccgcgactca tttcctgctg atgcaacaat
     7081 tagaatgtta ttttttcttg catagttaac aacttttctg aatgcttcta cagtaaatct
     7141 ttcgtcatct atttccatat ttttatatga gccaagactc acatttatta tatctacttg
     7201 atcatttgta gcatcaacta tagctttaag catatttata gagtttccat ctgtcccatc
     7261 catcaccttg taagaattta aatttactct tggagcaatc gtgtctatta ctccagcaac
     7321 ttgtgtacca tgaccatatt catctaactc aatatcatta acatagtttt ttaatcttag
     7381 gttattgtct tgaagattag gatgaagcct atctatcccc gagtcaatta gagctatggt
     7441 tatatctttc cctagttgtt ctttcactgg atcaatatga gataaaattt ttttatatgg
     7501 ccaattaaaa gacttaaaat ctttgtttaa aatattaata tttaaaatag aactattaac
     7561 ttcttcaggt ttaaaatctg gtaatttttt cccttccgaa acattaaaat atttacctat
     7621 aaacttccta tcactatcat ccaagttttt aaaactaact aatcctattt cctgtatata
     7681 atctactttt tcagaagata attcagactc aatttcttct atagcagttg tttgcgaatt
     7741 atcaataaaa aatgaaatat tatttgagag atctgatgca taacctgttg ttcctaatgt
     7801 aaaaaaaata tatgagatta aaatataagt caatcctctt tttttcattt tgtacctcca
     7861 aattgttgtt ttttgtaata cagtgaacga tataactcac tattttcaat aagatcctca
     7921 tgctttccaa tacatactat ttcaccatta tccattaata taattttatc aaagtttttc
     7981 acggtactaa ttctgtgagc aacggtaata actgttcttt tctcatctaa taaattagaa
     8041 aaaacttcaa attctgaaat attatccatt gcagatgtag gctcatctaa aagtaatgta
     8101 ttcacattag aatagaacgc tctagctaaa gcaatctttt gcctttgacc accagagaaa
     8161 ttattaccat tttctgatac tatagttttc tcatgctgag gaattcctaa aagtacctca
     8221 tccatttttg atttattcat actttctttt agtctttttt tctcatttat agaagaattc
     8281 ggtttaaact ctaaagaaat atttttttcg atagtttcat taaaaatatg cgcattttga
     8341 ttaacataaa aaatgtttct tctattattg gagttgtttg ataaaggata gccttcatac
     8401 aatatttctc cattagaagg ttgtaacaat cccgacaata gttttagtaa agtagatttt
     8461 cctgacccac ttctcccaac aatagctact ttatcccctt ttcttatgtc gaaagaaata
     8521 ccatttaaaa tatttttttc aaaaacagat atagtatagt aaacattatt aagcctataa
     8581 ataaactctt cttttccagc atttcctatt ttattattaa aattattttt ttcttcataa
     8641 gttaaaactt cagataattt ttgaaaatat acatttaata gtagaaagtc attataagag
     8701 gaaaccaaac ttagaattgg cttcataacc attgttacta tagaaacaaa accaattagt
     8761 gatcctaatg acaaagaatt gttgattatt aattttatac ctattattaa aaatagagct
     8821 ggcattacac tttgtatgat ttctggtaat attccaaaaa tagctatata tctattttta
     8881 ttttttgtaa ttaatagttg agacgtaaac atgtttttcc aatttaacaa aaagctcttt
     8941 tctgcgttag cagatttaat tgtttcaatt ccttcaattg cttctgtaat aattctctgg
     9001 acgtttcctt gttccattat ttctttatct acaaatcttt ttattgtatg cgaatttata
     9061 atacttaaaa aagctattaa agagattaga acaagagcta ttattgtcag taaaatagaa
     9121 tagttaacca ttaaaaacaa atatatccct aaaaaaagac tatctattaa agttgttatg
     9181 accttttgag acaatatttg cctaatataa atatttaagt tcgctctaaa cactaattct
     9241 cctgttgatc tattactaaa atacattagt ggcatactaa aaagtttatc aatataagaa
     9301 aacattaatt taaaatcaaa ttcatactga aattctgcta ctacagagct ttttaagtat
     9361 tgaactacat ataaaacaga aaaaaaacta gttaatatta ataacagaat ataggtagga
     9421 atttcttgaa aagatctaat attatctatc gaatactttg ttgcaatagg aattaagagt
     9481 aataaaagtt gtgaaacaaa tgataatatt attagactaa agaaatatct tttgaatttt
     9541 gtaaaaataa atgactttaa aaaaaactgt ttccttttgc cttctttttt agtctttttc
     9601 ttatgtgcgt atattaatat atttgaaaaa ttttttttaa attctgaaat atcaatccag
     9661 cgtttattac ttgcaggatc taagattaat acttttttct tttttatttt ctctatgatc
     9721 acaaaatgtt gattattcca atagcttatt acaggagtcg gaagatctaa ataatttgaa
     9781 aaacttgatt taaatgtcga tacatcaaat ccatattcgt caaagacagt acgaatattt
     9841 ttgatagtta gtcctccttt gggcacccca tatttttccc ttagttctac tagtgtactt
     9901 tgattaccat aataattaag tagcatagtg atgcatgcta aagcacattc actatgctct
     9961 ccttgcgcaa catacttcaa tcttttcata attacacctc ttataactca aaaagtaatg
    10021 cattcggaat ttcagaatct aggtttctca atagttcata acccacacca ctgattccta
    10081 caaagaatcc tagtgattct aaatactcac ttccagcaac ctttagtgta ttattttttt
    10141 caaaatcatt tagcatatag ctaataagtt tatttttttt atactgataa gtttcaggat
    10201 cttttttagc taattgaatt agcccttcca aagtacctgc atttccatga cacagacaat
    10261 ctttattttt atatgccatg gttttattaa tatctatatt tgaaatgtta tcatcatata
    10321 attcaattgt cgctaaaagt tcacctacag ttcccttaca ccaactattg tttttaggtt
    10381 cttcttcaaa gtatgattct ttaattttat gaagtaaaga atttgcctta tctatcctat
    10441 tgaattttga tagaagatgg acatagctat atataccgtg tccgaatcct ctaaaattaa
    10501 aatagggttc ttcggataat ttttcaaaaa tttctaatga aaattttcta tacttttcat
    10561 cctctgttat ctcggataac aataataaaa cttttattat actattatgc ccgtggatcc
    10621 aatcattttt taactcgcca ttatttatcg atttcttttc aatcaacatg tctgcaattt
    10681 ctacggctac atttaaagag tttatatcat tatttaagcg gtaatctaca agtaaaggat
    10741 atattaaact tccttttcca aaaaaagctg acaatatatc ttcagatggt attgtataaa
    10801 ttgaattttt tatacattca attacatagt catatttatg attctttgta atgtatttaa
    10861 gagccacata aaatacgaat ataccaggca atccatcgta catattatta tttaggatgc
    10921 ccacattcca atcttgatcc aattttatgt caatccaatt tacagtattg gtttttttat
    10981 taaaaatagc tctcttgaaa atttttttct ctatcttctg acatgcttga ataattttac
    11041 tgtttagctc tgagccagta taaatatatt tatttgaatt ttgatttttc aaatcattaa
    11101 tatatttata tggattataa atattcaaag caatttctag ccaaacggtt tgaatagaaa
    11161 tatcttcatc acaaagatca tttattttat ttaggcatct attcaaagcg ctttcttgat
    11221 aaaaatcttc tactaagcac ccgtcactag ctattaatga tgtttttgag atattgttat
    11281 aaaaaatggg tatatctcca tctattaagt ctgaaaattc gtaatgaaca acctttttat
    11341 tcttatatgg ataggcccac atattatgaa gtactttttc tctctctatt gcattagaaa
    11401 agcaattagg atggtatgaa aattccaaca tatcagcata tctttgagtt ggtctgatta
    11461 catttctaac tataagattt tgtaaattat tattaatata tgccaatatt tttttcttag
    11521 aatcctttgc tttcattaaa atacttttca taccagtaac tatatatttt tcatagctga
    11581 taaaactaat tttttcatta ttcataattg gagtattttt tgcagtatcc ataatgtgtg
    11641 tttgatattc aaaacgcatt tcatcagtaa atgtattttt aatttttaat atcttgaacg
    11701 gtacgctttg ctctttaaag tttaacgcac taaggttaac cccttcatct ttcgaatctg
    11761 acttatcttt catcgctaaa tatggtacta gccctgtcac cattatagaa tctaaatatt
    11821 tatatttagc atctactgtt gcgctattac caaactctat aggaatattt tgttgaaaaa
    11881 aagtttcgtt atctatgata acagggtatt ctccatgagc gattatattc tcatagtgta
    11941 agtctgttac attaaataag aaagctattc cgattagttt accatacctt tcataatatt
    12001 tttttacttc ttctgtgtta tttatttcta tattatctat atattcttca tagaaatagg
    12061 tatttctagt aactttttta actatataaa tatctgcctc taactcttta tttaaaaatt
    12121 caaataaatc gcttaattta ttctcgctat taatctttgg cttgtatact atcttctttc
    12181 catcagaaaa agttagtgta gaaacagtat ttccgcgact atgagagtct ccctgtgatt
    12241 ctgatataga gttaagctct gaggattgta tgttaaaaca attttgtatg ctaggtaaat
    12301 cttcagtcac tcttataagc atttgtttag tattatctaa aaaatatctc attctaacaa
    12361 cagtaatacg catcaactca ggatagcatg tataaaaagc tattatatct tttttagagt
    12421 taaatctttt ttttagataa tagataaatc gcttgctact atcatttccc tttagaggtt
    12481 catttttttt aaaagtatgc aaatctagca ctaatgtttt gcttgtcaag tgaataagct
    12541 cttgtgttag agtttctaat aaattaataa tgaattcttt tgtacaaata tttaactctg
    12601 agtttaaatc aagtaaaaat aaacgagcat actgtaagaa atatctaaaa ggataactag
    12661 catctacttc taataattgc tcttcactat cattataaga atctaaaata gattcaaaaa
    12721 aaatatacca tgattgatct ttaatgtatt gaattgcaac ttctttatca ggaaagtttt
    12781 caataggtgt tattcctaat ccaaaattat ccagtgattc atatttatat ttaatcaagt
    12841 agtctaaatc atcttgttta agaacacttt ttctttcttt ccaagcttgt aaatttttaa
    12901 tgtcgtattt ctcgttacca ctttgcttta gtaaaaaaca tctttcattt atgcttaata
    12961 catttattaa attatcttcc atgtaagcac tcctttttta tgtataagag ggctagtgaa
    13021 actagccctc ttaatatata aattagcaaa atttagctga aaataatgca cctactccta
    13081 agcctatggt aaaacatgct ggagtagtct cagcctgaac atctccacta ccttgaatcg
    13141 cttccatttc ttctaaactt aactcttcaa aagaaggacc aacaagttct aatttattag
    13201 agtaatagtt ttcttgattt tccttattta gcactgtgct tcacctcact aagttttata
    13261 gtatatttta acaatgtttt aaagacacaa ctacagttac tccagtaaaa ataccgccac
    13321 caacccagcc acaagcagca ctacttgctg cagctgtcgc cgcaacagca cacaccggtg
    13381 ttgtctcagc ctgaacatct ccactacctt gaatcgcttc catttcctca acacttagtt
    13441 cttcaaaact aggaactaca tttaaatttt ccataattct taccctccat cataaaattg
    13501 ttgtatactg cataacataa tatgttacaa tttaatagta tagagctttt aatcttttgt
    13561 caagtggcac ttgacaaaaa ggaggaacca aaatggctat ttttattttt ttattggata
    13621 tcatttctgt agtctacttt gtttttaatc tgactgattc aaaaaaagat gagcgaattt
    13681 tatatacaat ttccttaaca tctacttaca tgtacttatt tattaacttt tccatactta
    13741 tagtaattgc tatttttctt ttactaccta atgttattac taaaaactat ctatttaatt
    13801 ttatctacta ttacttctct ctatcaatga tattgcactc tctgttacta ctttttttca
    13861 acaagaggac ttcataaatg ataatcaata acttaaaatt aattagagag aaaaaaaaaa
    13921 tcagccaaag tgaattagct gctttattag aagttagcag acaaactatt aatggtatag
    13981 aaaaaaataa atataaccct tctttacagt tagcattaaa aattgcttac tacctgaata
    14041 ctccactaga agatattttt caatggcaac ctgaataaaa gagattttta aatttcacca
    14101 cagaatattt aaattaaaag aaaggtgctt cgtatgaaga aaaagtttat atcccttctg
    14161 attttatttt taggaataat tgttggcata gtaacagttt atattttaaa gcataaataa
    14221 ttatgactgt tattttatac tttaatcata actgattttt taacagtaaa accctccctt
    14281 atgattacgt tcatttttat tcttatacag ctcatttaaa ataaaaacta ggctcaaatg
    14341 tataataaag actgtctctt ctggggtgga gacagtctct aaggttataa cttattttag
    14401 tctttcattt ctaacgaata ctcatagaac taaacgattg attcattcag tctgtaagaa
    14461 aatagttaaa tctgaagtga cttgtaatta ttctacagta tacacactat cctttcaaca
    14521 actgtcgaaa gtttagcaaa acattttaca atatttttgt atacatcatt attaataata
    14581 gagccaatac cagaaaatat ccgcatagca ctttaaaggt tctactttgg ttattttcag
    14641 gtagctgact tattaaataa acacctgaca tcattataag aacataagta aaatagtaag
    14701 tccttgatcc agatacccat atggtaggag agaaccccat cataatgcga cttcctacac
    14761 ccaaaataag aagaaaggta actgccaaaa attataaagg attattactt gccccaataa
    14821 tccctattac ataaaaaaaa ccaacccagt aagaagaact actagtgaca tatatgtttt
    14881 tcctgaagct atatcataag tttgattaat gatcgtatta aatcttgtac aaatcaaata
    14941 cgtcaatagc ggtattccac taatcatctt tttgactaat gttccatttt ttactagtcc
    15001 agcagtaaga attagcaata caaaagctaa catcaatgga gaccactcaa aaaataaagc
    15061 tttcaaagtg gacgaatacc ctatttgtaa cttatcaaaa atactgtagc tagaaaaatt
    15121 aggtaaccat tgtttcgttt cttggacgtt tcttgccgca ttccccttac atgttaaaat
    15181 aaacacaaag ctagcgatta caatagcaat atgaggtaaa gttatcaaga tattcatttt
    15241 agataaatat agaatacctg ccaaaactaa taaagaaact aacataatga ctaccatttg
    15301 ttcttgattt gtagcataaa tcaagaacac caacgataaa ataaaggata gccaatttac
    15361 actttttcct cttatatagt tcataatagg ccaaatactt aacaacgctg ctgccatgac
    15421 ccaaacataa tttgttgttg ttgctatcca tcctgcatta tttatcatcg aagcaggaat
    15481 taataatgac atgccagtac ctataattaa tccacttcga ctattatctg cgttaaacag
    15541 tagtgcaggg acaattgcca ctatagacat tgctatagca tttaaaatcc tccacaaaaa
    15601 tacgtgttgt accgcttgtg ttagagctat ttcaatcact aatcgggacg tccactcatt
    15661 gtatctaaac ttcaaaaatt cataatagtt actttgaaaa tcatgtgtaa actgctttaa
    15721 gaaaaacgca tcgtccccaa attccatttg ttcaatacca aaattgtaaa ttaacattac
    15781 cacaaaaaca aaactactga gaattaaaat atctatcttt tccactttat ttgtcactat
    15841 gtcactccta tcctccattt ttttcaagaa catgcgctct ataaatacta tcgatacttg
    15901 acattggaag cttttctagt tcttcatacg taaagtcact attacgtaca atcaatagta
    15961 tcttctcttc tttagtcata tatcttccct cactttcatt gttttatcta tttttttacc
    16021 ctctttataa ttgaacacaa tgtttagctg cactttgtat tcataaacat taaggcatta
    16081 atccattctt acgaaaaaat attccaattt ataaaggact ttatttaatt tgattttttt
    16141 cgtttctaat cagtttctca tagtactttt gcgctttttg attggtaaaa gcagtttatg
    16201 tctcccattt ttgggattat cttaacttcc attttcacct atctgaaagt tttcgtcaat
    16261 gtcaaagtta acgcttgacg tatagtcaag taaatgctcg cgattcacaa tcggttcccc
    16321 ttcaagggat ttaactcccc ataaatcgct ttgcttttct cacatggtaa tatctaaact
    16381 agattgtccg ttattaacat tcccaacgga ctttgaacta ctttttaagt caaggttaac
    16441 tacctaatta tattattcct aaccatatcc gggaacattc ttgttctttg atccatttgt
    16501 aaattagtat tcgactgctt cttttctgta ctagtcagtt gctaccagct aaaatcctca
    16561 tttaacaatt ctacttgctc attgaacggt tgattacaac ataattcagg taaatttgct
    16621 cttactaaag cctcagcgca atttggcaca accatgtttc ctattctagc cacctgttta
    16681 gccttactta ttttctttcc gttcttacct ttatctaata catatgtgtc tgggacacct
    16741 tgtgcttttg ctaattcatg aggttgaagc attcgcattg tgatatcaac gattctatag
    16801 gcacttcctt taacttttac taacccaaat cggtcttttg tagggatcgt atggagtggt
    16861 tcattcaaat gttgccctat gtcagatcca tagtttttcg caagaaaaga cgaaatcaac
    16921 atatggtgac cactagtagt gatagttgct aatggagcag atattttcgt tccagagtgt
    16981 cctgtagtat tcacacctat aattggactg agtagcagct gttctgcttt atttgtgctc
    17041 gtcgttaaag gctcctttat cgaatttgta cgtttaactt tcccataact agtttgatca
    17101 attctaacaa tatacggatc taccgtatta agtacaaact tgtttagtcc gcgagcaatt
    17161 cttttcaacg tattaggacg taaaggtttc ttacgaccaa aaatagaatt atctggtatt
    17221 gaccaatcaa tacaacttgc agctgattga taaggaaggt atttcccttc agcaacttct
    17281 ttactttctc ttgacccatg cgttggtgtt ggccaaacaa tcggtttatg atcccggcgt
    17341 gctatcataa ataaccgttt tcgtgtagta ggcgcaccat agtcacacgc acgtaactct
    17401 ttaaactcaa catgatagtc ttgacgttcc aatgctctca caaaggattg gaatgttttc
    17461 ccctttttct tgggatctgg ctttggacca tctttagtga caatcaaagg accccatgtc
    17521 ttaaattctt cgacattctc caaaataatg acacgtggtt taacagtagc tgtccaacga
    17581 acagcaatcc atgctaaccc tcgtatcttt ttatttacag gtgttcctcc ttttgcttta
    17641 gaaaagtgtt tacaatcagg gcttaaccaa cacaacgcta ctggccgtcc attggcaaca
    17701 tctctcgggt ggactcccaa acactttcac aatagtgttt tgtgtttggg tgattggctt
    17761 catgcatagc aattgcatca ggatcatgat taatggcaac atctaccgaa cgtcctattg
    17821 catgctctgt gcctgtgcta gcaccaccac cgcccgcaaa attatctaca acaatttcct
    17881 tcaaaaaatc accttcctaa cttaacctac attttttcat cctaaaatat gtcactttta
    17941 agctattctc caaatacctt tagtaactca tagcgacctc taatcaattt ttccattgtg
    18001 tgcgctggat aatatctttt cttattgtct gactagcttt tttcataaca gactatttct
    18061 tcccacattg tggcggcttc ttcagatact tcaaaataaa tcctcttctt ttgctgtgta
    18121 ccttacttat ttaggtgtgt acctgtcatg tcctcatctc tcttagaaac cgttatttta
    18181 aattattttt gtataaccat catgttactc cagtttccta cttttatttt caatttttcc
    18241 atcgcatttt cagctctctt ttttgacgtg tagtctttcg catttcttat atcgtccaca
    18301 aaattgccaa atacttctcc ttgaacagta tatgttgtgc ctgaatagta ataccattgt
    18361 tcaacaccac caccaaaatt ttgagaaact ttaattacaa aattcttttt acatcccatt
    18421 ttcctgtctc ccttttcaaa tttttttaga actaactctt atttttcttt agtcttttct
    18481 cttacttctc cgcgatactt tctcccttgt ggtgttttaa gaaaatcaac tagtttctcg
    18541 tttgattcaa actttttaat ttttcttgtc attttattgc tacatattca aattcagtca
    18601 taatcattct cccttattta aaccctttgt ctgtcacata gcctggtata ctccagattc
    18661 tgagtgattc actttttgcc tgttcttggg cttgctctag ttctgacaaa tacttagtgt
    18721 taggttcttt gacataagct acacgtgcta atccctctct cacaagtgtt ttttgtagta
    18781 atgttccatc tacaaaaata taacccaacg ctctaccgta acgatctttt ttattccctt
    18841 gatcatattc aaaagtaatt tctgaagtag tagacaaaag ctcttttgta cgtttgctag
    18901 cttctaagcc aaacggctga acttttgtgt ttggtttgac ggtctccgtg tatcgattaa
    18961 taaaaagcgt actttctgtt ctttgtcttc aatcttcaaa accgttgtgt caccgtctac
    19021 gtgacgaaca aaatcagctg gtatacgttg atcatttgaa atagtttgaa aaaagccttc
    19081 ataaacatct tgttctaggt cttgaacaaa atcttgtgct ttttgttcaa catttgtaca
    19141 acctgataat agaagagaat gggacaataa tcagaaaaaa atctgattat tgtctcattt
    19201 ttttgattaa tgactttagt cagtcgaaat ctctaaagag atttcgacaa aaaaaccacg
    19261 cgtactgcgc gtggaggaac tagctttagc gataaaaact cctttcgata taatagataa
    19321 aggctaccaa ccgttatcta atcgaaagga gtttttgtat gtcgaacgac gataaaagtt
    19381 tagcacatac tcgttggaat tgtaagtacc atcttgtatt tacaccaaaa tatagaagaa
    19441 aagtaatcta tgatcagtta aggcaggata ttggaaaaat actgagaaaa ttgtgtgaaa
    19501 tgaaagaagt cgaaatcatt gaagctcatg caatgcttga ccatatccat atgttggtaa
    19561 gaatcccgcc gaagttgagt gtatcaggat tcatgggttt gttaaaagga agaagtgcag
    19621 taatcattca tgaacgtcat gcgaatttaa aatataatta tgggaatcga tcattttggt
    19681 caaaaggcta ttatgtgagt actgtaggtc tgaaccaaaa aacgatagct aagtatatac
    19741 gagaacaaga agcagaagat cgagtaagag atagtataaa caaaatagag tatagagatc
    19801 catttagtaa gtaacaacta gttaatgata gaaaggtagc ggttggcgat ctattaaaaa
    19861 agctccctta aagggagcgg caggtagcga gcccttctag ggctattaaa aagccacccg
    19921 ctatgcgggt ggatatttac ttggagaaag gactattgtc ccacgctctt ttccaataaa
    19981 tagtttcatt ttctaactcc ttaacttttt ttccgtttta aagaatactc aattttcttt
    20041 ttttctaacc tatcaaacgt taatccttca acagcttgtt cccattctgt ttgttgtgct
    20101 gtacgtttct ttgtactgtc tgcatatatt ttttgtaaat tttcattacc catgaatcaa
    20161 tcctccttaa aacggtaagt cacgatctga aatctcaata gaactacctt ctaaatctgg
    20221 aaagggttgt tgcgtattgc tttcctgctg tccaactggt gtaggattag aagcgttaac
    20281 accacgttgt tgactaactt cttttgactc taacaattgg aagctttcta caaccatttc
    20341 tgtcacataa atacgttgtc cttgttgatt ctcatagtta cgtgtttgaa gtctacccac
    20401 aagaccaatc aatgttcctt ttcgtgtata gtttgctaaa gcttctgcag gtttacgcca
    20461 aatcacacac tgaatatagt ctgcttcacg ttcaccattt tgatttgtaa aatttcggtt
    20521 aactgctagt gtaaaagctg caacagctac accacttgac gtataacgca aatcacagtc
    20581 ttttgtaagt cttcctacta aagtcacatt attaatcatt taaaaaacct ctttctatta
    20641 tttttttaga agtgatagca actagtacta tcacttctaa atatttactg ttttactaaa
    20701 ccaccaaaca tatttttaaa cttgatttca ccaaactctg aaaggaacgg atacgtttcg
    20761 tttaagccgt aagtgtattg gtaattctct acaatacttt gatggtccat ttcccagtcc
    20821 tcttcatacg gagatatata aaacaagtac aacatcgtta taccccccat atacttttgt
    20881 tcaatcgcat agtatacaag tatattgtgc aatcgtcgct tcatgtattc ccattaatcg
    20941 cattcttttt agtgcttctt ctttttttca ttattcattt tgttccctcc atctcttaac
    21001 cttatatcta tatcatactt tataatgtgt actttataaa gtattgtatt gtattttttt
    21061 actttataag gtatacttta tatatcaata aagaggaggg ataacattga atcaactaga
    21121 gttcaatgag ctattagaca aaaatcctca atttttaaag gcttatctac aagaaaattt
    21181 gttaactaaa gacgaagcac ctaaatatac gaagcaaaca caggccggct ttgatcaatc
    21241 tgcaaaaatc ggaacaacta tccaaccatt tttttctaaa caaaaaaacg gccgcaccac
    21301 atttaagtta tatctaaagt ctgaaatgat agaatatgga aaaaacaaaa gaaataaata
    21361 aaaagaccac ctaaaaatca ggaagtcttt cactagtatt tcagcacccc ttgtgctaat
    21421 atataaatga aaagagagct gtgcgctaac acaactctct ggtgtagaac cgtttaagac
    21481 ggtagcagat ttaattacag attagtaacc gttatctagc caaagatatg aacggttact
    21541 ttttttgtcg ttgtttacag cgctcaagat tccaaagatt aagcttgcga ttaaagaacc
    21601 gaaactaatc atcagagcta aggcttctgc gatagacaaa aggcttctcc tttcatagat
    21661 tttagtactt actttcataa gcaccaccac ctctcggaag atgccaccgc cataactttt
    21721 ctacttactt agtataccac aaaacagata gttcttcctt acatacttat tgcgcgagac
    21781 atgttcttta agctatgata aaaaaacaat gaaagggctg ataatttgga tactaaaaca
    21841 cttgaacact atcaaaaatg gtgccaagaa aacttactca atcgaacaga agcaatgacc
    21901 atcacgaaac aaagcaaaac agcgtttgca caatctgttt atacaaaaca gttagtaccg
    21961 tttattgaaa aaaaggtgac aagccatccg gaactgttcg tttattttta aaacaagacg
    22021 tagaagcata cgcaataaga atacagaaca gacaacagaa tcaaccaaca aaaaagccat
    22081 cacaataact gggatggctt tttttagtaa ccaatctcta cctggtctat ttgttctatc
    22141 aattgctctt ttcttgtaga ttttgattta tcttgttcta aacttatttg tatttcttga
    22201 ttcaatttga tttgtaatgc ttttttcatt caactctttt tcctgtggga aagttcctgc
    22261 ttgtcgcttc aggggtcaac tttatcttcc tttcattccc cctcacgcca atcatatcta
    22321 attagatatg attggccaag taaggcgata acgtatttta tttaaatatc atgactaatt
    22381 ccgttaaatt gttcattttc atttatttta tttttcgttt tgtactgatt attgtttttt
    22441 gacaaggagt ctacttctat attttttaaa aagtgattat atgcttgaac tatttcttcg
    22501 ttttcttcga caatatcaat atcataaaga taactttcag agttttgttc ctcaaaaccg
    22561 ccttcttgat attcttctga attgagcttt tcagttccca cttgtagagt attttccaac
    22621 tgttcaataa taaaattctc ctcctctaac tgcttcaata cctcaacttg ttcttgtgaa
    22681 taatgattat ccatcactgt taatactgta cgtgtttcag gaacaatctg aattaattct
    22741 tctaacttta atgaatgaaa gtcagggtga taccgatcaa tagaaatatc tttaaaaaaa
    22801 gcttcaatag atccatgatc aacatctctc gtgtaaccat ctccgtcttc tgaatagcca
    22861 ctccataaag tcccatcttg aaaaacataa atggcttgtt caaagctttc tgtcttttcg
    22921 aaaccttctt cataaaaatc tgagaagtca aacctagaat tattttctgt cattttccat
    22981 cc
//
