LOCUS       NZ_MOOT01000060        25239 bp    DNA     linear   CON 20-MAY-2024
DEFINITION  Bacillus thuringiensis serovar dakota strain BGSC 4R1 contig000060,
            whole genome shotgun sequence.
ACCESSION   NZ_MOOT01000060
VERSION     NZ_MOOT01000060.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis serovar dakota
  ORGANISM  Bacillus thuringiensis serovar dakota
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 112951)
  AUTHORS   Zheng,J., Gao,Q., Liu,H., Peng,D., Ruan,L. and Sun,M.
  TITLE     Comparative genomics of Bacillus thuringiensis reveals a path to
            pathogens against multiple invertebrate hosts
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 112951)
  AUTHORS   Zheng,J., Gao,Q., Liu,H., Peng,D., Ruan,L. and Sun,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) State Key Laboratory of Agricultural
            Microbiology, Huazhong Agricultural University, 1st Shizishan,
            Wuhan, Hubei 430070, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 1.5.2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002148095.1-RS_2024_05_20
            Annotation Date                   :: 05/20/2024 01:21:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,175
            CDSs (total)                      :: 6,055
            Genes (coding)                    :: 5,836
            CDSs (with protein)               :: 5,836
            Genes (RNA)                       :: 120
            rRNAs                             :: 4, 7, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 7, 6 (5S, 16S, 23S)
            tRNAs                             :: 98
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 219
            CDSs (without protein)            :: 219
            Pseudo Genes (ambiguous residues) :: 0 of 219
            Pseudo Genes (frameshifted)       :: 88 of 219
            Pseudo Genes (incomplete)         :: 138 of 219
            Pseudo Genes (internal stop)      :: 66 of 219
            Pseudo Genes (multiple problems)  :: 56 of 219
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:21:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 71569
            Orig. end                         :: 96808
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MOOT01000060.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="2"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15239)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(357..1094)
                     /locus_tag="BK765_RS23390"
                     /old_locus_tag="BK765_22225"
     CDS             complement(357..1094)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="BK765_RS23390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22225"
                     /product="S-adenosylhomocysteine nucleosidase"
                     /protein_id="WP_140159747.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRLYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEYLIAFLRVYEINVVNNR"
     gene            complement(1091..>1396)
                     /locus_tag="BK765_RS32105"
                     /old_locus_tag="BK765_22230"
                     /pseudo=""
     CDS             complement(1091..>1396)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="BK765_RS32105"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22230"
                     /product="DUF3885 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYCTYQFSLKCLAEDIKYESLIQAANHEDFSVLYPRFGRKKEISY
                     PDVFLINATKDIVMFMYDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNLFK"
     misc_feature    complement(1456..1470)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    1458..1472
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     gene            complement(<1538..1909)
                     /locus_tag="BK765_RS23400"
                     /old_locus_tag="BK765_22235"
                     /pseudo=""
     CDS             complement(<1538..1909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002110027.1"
                     /locus_tag="BK765_RS23400"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22235"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLVPYLYSQWGNHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENTKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADL"
     gene            complement(1923..2531)
                     /gene="yqeK"
                     /locus_tag="BK765_RS23405"
                     /old_locus_tag="BK765_22240"
     CDS             complement(1923..2531)
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="BK765_RS23405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22240"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_086398381.1"
                     /transl_table=11
                     /translation="MLYNDIYSFAPTGKIDNDIKDFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIARYLHDISGIFPNEERIAVAEEFGVEIEGAERKFPMIIHQKLSRVI
                     AKEIFKVEDEDVLDAICCHTTLRKHPTKMDLVLFVADKIEWDQKGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWYLKRIVQ"
     gene            2724..3419
                     /locus_tag="BK765_RS23410"
                     /old_locus_tag="BK765_22245"
     CDS             2724..3419
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="BK765_RS23410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22245"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038808.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKFIHTV
                     WGVGYKIEK"
     gene            3409..4566
                     /locus_tag="BK765_RS23415"
                     /old_locus_tag="BK765_22250"
     CDS             3409..4566
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001243314.1"
                     /locus_tag="BK765_RS23415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22250"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243314.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGVKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYET
                     CIKKMIEEIRYIANGNFNHKVSVVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKG"
     gene            4742..5758
                     /locus_tag="BK765_RS23420"
                     /old_locus_tag="BK765_22255"
     CDS             4742..5758
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="BK765_RS23420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22255"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_001160048.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSAALSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTVLMNKKAKELKLLQPSPFLNS
                     TGINNDTNKQSTTTAIDVAKLAARLIKDFPDVLNITKLTSYQFSFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLEDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(5820..>5909)
                     /locus_tag="BK765_RS32110"
                     /pseudo=""
     CDS             complement(5820..>5909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="BK765_RS32110"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEIHHIGQLSIWARQLNLQPVSANLIGRG"
     gene            6091..6228
                     /locus_tag="BK765_RS23425"
                     /old_locus_tag="BK765_22260"
     CDS             6091..6228
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="BK765_RS23425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22260"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     gene            6837..7445
                     /locus_tag="BK765_RS23430"
                     /old_locus_tag="BK765_22265"
     CDS             6837..7445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="BK765_RS23430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22265"
                     /product="hypothetical protein"
                     /protein_id="WP_000136050.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTNFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLPFECFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(7717..8250)
                     /locus_tag="BK765_RS23435"
                     /old_locus_tag="BK765_22270"
     CDS             complement(7717..8250)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="BK765_RS23435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22270"
                     /product="GNAT family protein"
                     /protein_id="WP_000990084.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLESFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEVTSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAIFCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     misc_feature    complement(8326..8341)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(8356..8712)
                     /locus_tag="BK765_RS23440"
                     /old_locus_tag="BK765_22275"
     CDS             complement(8356..8712)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="BK765_RS23440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22275"
                     /product="hypothetical protein"
                     /protein_id="WP_000535572.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDLVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     gene            9312..9683
                     /locus_tag="BK765_RS23445"
                     /old_locus_tag="BK765_22280"
     CDS             9312..9683
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BK765_RS23445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BK765_22280"
                     /product="hypothetical protein"
                     /protein_id="WP_042992790.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSIVMMIGGNLKKS
                     VIVTMIGGNLKKSVIVMMIGVLNEISVVVNVSLFVAIVKEKIGNFFNVNVKERIWLLEP
                     IGLFRKVNPTPTSLLSLNF"
     gene            complement(10001..11941)
                     /locus_tag="BK765_RS23450"
                     /old_locus_tag="BK765_22285"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 4e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_BK765_RS23450_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="BK765_RS23450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22285"
                     /product="AMP-binding protein"
                     /protein_id="WP_044784297.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-89, bitscore:
                     293.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYSWMKSLGYEDYETFYNKSIEETAWLW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BK765_RS23450_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="BK765_RS23450"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11644)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BK765_RS23450_AMP-binding.1"
                     /evalue="4.00E-82"
                     /label="BK765_RS23450_AMP-binding.1"
                     /locus_tag="BK765_RS23450"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BK765_RS23450_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="BK765_RS23450"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11991..13532)
                     /locus_tag="BK765_RS23455"
                     /old_locus_tag="BK765_22290"
     CDS             complement(11991..13532)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="BK765_RS23455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22290"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_086398382.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKALEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCNAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13535..14323)
                     /locus_tag="BK765_RS23460"
                     /old_locus_tag="BK765_22295"
     CDS             complement(13535..14323)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.6e-75. Score:
                     245.5. Matches aSDomain:
                     nrpspksdomains_BK765_RS23460_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="BK765_RS23460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22295"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939814.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLDELQTILTQI
                     SEDSNVRVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRIEGLQAFKEKRKPMYKGE"
     aSDomain        complement(13562..14281)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BK765_RS23460_ECH.1"
                     /evalue="1.60E-75"
                     /label="BK765_RS23460_ECH.1"
                     /locus_tag="BK765_RS23460"
                     /protein_end="254"
                     /protein_start="14"
                     /score="245.5"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLDELQTILTQISEDSNVRVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRIEGLQAFKEK"
     gene            complement(14328..15239)
                     /gene="mvaB"
                     /locus_tag="BK765_RS23465"
                     /old_locus_tag="BK765_22300"
     CDS             complement(14328..15239)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="BK765_RS23465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22300"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775435.1"
                     /sec_met_domain="HMGL-like (E-value: 5e-49, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15261..15476)
                     /locus_tag="BK765_RS23470"
                     /old_locus_tag="BK765_22305"
     CDS             complement(15261..15476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="BK765_RS23470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22305"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            complement(15503..16840)
                     /locus_tag="BK765_RS23475"
                     /old_locus_tag="BK765_22310"
     CDS             complement(15503..16840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="BK765_RS23475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22310"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486742.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 5.9e-12,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 7.9e-08, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 6.5e-08, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1e-10, bitscore: 34.3,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            complement(16856..18001)
                     /locus_tag="BK765_RS23480"
                     /old_locus_tag="BK765_22315"
     CDS             complement(16856..18001)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="BK765_RS23480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22315"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397282.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.9e-28, bitscore:
                     89.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.6e-58, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18218..19186)
                     /locus_tag="BK765_RS23485"
                     /old_locus_tag="BK765_22320"
     CDS             complement(18218..19186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="BK765_RS23485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22320"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_001248638.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKELVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            19420..19719
                     /locus_tag="BK765_RS23490"
                     /old_locus_tag="BK765_22325"
     CDS             19420..19719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="BK765_RS23490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22325"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728159.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLTLSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            complement(19841..20494)
                     /locus_tag="BK765_RS23495"
                     /old_locus_tag="BK765_22330"
     CDS             complement(19841..20494)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168192.1"
                     /locus_tag="BK765_RS23495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22330"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_001168192.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYEGLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRI"
     gene            complement(20519..21538)
                     /locus_tag="BK765_RS23500"
                     /old_locus_tag="BK765_22335"
     CDS             complement(20519..21538)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="BK765_RS23500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22335"
                     /product="ABC transporter permease"
                     /protein_id="WP_086398383.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKNQEASIYEYSKVNAISELEKQKVDAILQIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNFLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPIRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVVG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            complement(21535..22260)
                     /locus_tag="BK765_RS23505"
                     /old_locus_tag="BK765_22340"
     CDS             complement(21535..22260)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="BK765_RS23505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187075.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVSS"
     gene            complement(22449..22700)
                     /locus_tag="BK765_RS23510"
                     /old_locus_tag="BK765_22345"
     CDS             complement(22449..22700)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="BK765_RS23510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22345"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            complement(22916..23758)
                     /locus_tag="BK765_RS23515"
                     /old_locus_tag="BK765_22350"
     CDS             complement(22916..23758)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="BK765_RS23515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22350"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727189.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.8e-09, bitscore:
                     30.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            complement(24037..24963)
                     /gene="bla"
                     /locus_tag="BK765_RS23520"
                     /old_locus_tag="BK765_22355"
     CDS             complement(24037..24963)
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="BK765_RS23520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BK765_22355"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_002082757.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEASYDNQLIAEATEVIVKALR"
ORIGIN
        1 atcctttata ccacctaata ttacgccaac tgatttgtca ccgtctaaag caagaaaaga
       61 atgttctagc aaattacctt ctggtccaaa aaaacgttgt ataaaaccct cttttgaaac
      121 ttccatctta ataatataat cggaaaatcc atctttaaaa gcttcatata ctaaatcaat
      181 atttacttca ctacaccttt tatattgaat catataaaat tgccctccaa ttgcttgtat
      241 taatctcaac atgtacccat ataatatatt ccatctatta taaatttcag ctcttaattt
      301 gaaatgaacg gacatttccc tacatataac ttactattaa tttgttttat aacaaactat
      361 ctattattta ctacattaat ctcataaaca cgtaaaaaag caattaaata ctcacatgct
      421 ctttcgcatg ctagcatttt aaagattttt tgttcttctt tcgttttatc atttgcttga
      481 tctgaagcag cttttaaaca taaaaatggt tttttattta tttgacacac ataggcgaaa
      541 gctgctactt cttgatcaac tgccaatgct ccgtatacag tatgaagtaa atatctcatt
      601 tctgaactac gaatacgttg atctccagat aaaaatgtac cgaaatgtat cggatcatac
      661 aatcgtattt tttttattct tcttacaagt gattttgttg tttcaatagg tgctgttcta
      721 ccgttatata aattaaaaac atcttctcct gagccagcag cagtaacatc gtgttgtatt
      781 gcgtttagtg ctactacaat atgaccgttt ttcactttgt ttgataaact tccgcatatt
      841 cctgtcataa acaactcatc tggctgaaac tcactaatta acaattgtac acaactagcg
      901 cagcttactt taccgacacc agttacaact gatataattt ccagctcatt gatagtatga
      961 aaatgaaatt cccaagctgc tcttttttca acacgttcac tcggataatg ttgatgcaaa
     1021 tacgtcagtt ctggttccca tgcagataca attgcaatac gtttcattac acgcttcact
     1081 tcccctattg tcatttaaat aagttatcta tactttctcg ttcataatct ggaatccatt
     1141 ctttatattt cttatataaa tctcgtatta tttctttatt cttcgcaatt acttcacatc
     1201 ctctatcatc atacataaac atgacaatat ctttcgttgc atttatgaga aatacatctg
     1261 gataagaaat ttcttttttc cgtccaaatc gaggatacaa aacagagaaa tcctcatgat
     1321 tagcagcttg tataagcgat tcatatttaa tatcttccgc aagacatttt aaagaaaatt
     1381 gatatgtaca atataatgtg aaactttaat cagttcatcc cccactgatt atcagccctc
     1441 accaatcggg cttttagggg cagcccgccc cccacctacc ttctttgctt tcgctgaatt
     1501 ttgaggtggg ggtcttactg cccggcaaat agcgggataa atctgcctct tcatcttcaa
     1561 atagaaacgg taacgtttct tgtcttatat gaaatcttaa atctcttttc ttaatatatt
     1621 tattgtatac atttattttc tgtggagttt ttgtgttttc ctttttaaat ctataaacat
     1681 ttgtcactac aaacactaca tcttcttttg aaaatatgtc ttcaaataag aatttattat
     1741 atgtatacag ctgagaaaag tattccatat ttaaatcgtc ggttccttct acaatttgat
     1801 atttatcttt tccaaaatca aaatacaaat gatttcccca ctgagaatat aagtacggta
     1861 ctaatgtaac tcctggaaat gtttgattca tatattcttt taattgcatt tccttgtccc
     1921 ttctactgta caattctttt taaataccaa tatgcttctt ctagccacgg atgtataact
     1981 ttcaatgtat ctttcctttc ccacaaatat gaaatatata caaaagcagc tttttccaaa
     2041 gatttttcca atcctttttt tatttctatt aaatatggtg gtgtcccctt ttgatcccat
     2101 tctattttat ctgcaacaaa taaaactaaa tccatctttg ttgggtgttt acgcagtgta
     2161 gtatgacaac aaattgcatc taatacgtct tcatcttcta ctttaaatat ttcttttgcg
     2221 attactctcg atagtttttg atgaataatc ataggaaact ttctttctgc tccctctatt
     2281 tctaccccaa attcttcagc aactgcaatc cgctcctcat tcggaaaaat gccactaata
     2341 tcatgtaaat atcttgcaat tgctgctttt tctttatcta cgtgaaactt ttctgcaatc
     2401 ttttttgcct catttgccac acgaattgaa tgtttatatg taaactcttt attatatttt
     2461 agtagaaaat ctttaatatc attgtctatt tttccagttg gagcaaatga atatatatca
     2521 ttatataaca tagaaaatcc cccttataac taactttcag tataatgcag aatttaaata
     2581 tctttgttat tttatattcg ttattaatct ttttactcct ttttaatacg ttacatgaaa
     2641 ttttatacag aatcattgct acaagtacat aaatgtttga tattatagta atgttgatga
     2701 tttgtaagga aaggaactac aaaatgaata aaaacatatt aattattgat gatgataaag
     2761 aaattgttga attacttgct gtttatttgc gaaatgaagg ctataacatt tataaagctt
     2821 atgatggcga tgaagcattg cagaaggttt ctacatatga agttgacctt atgattttgg
     2881 atattatgat gccaaaacga aacggattag aagtttgtca ggaagtacgt gaaaataata
     2941 ctgtaccaat tctaatgctt agtgcaaaag cagaagatat ggataaaata ttaggtctta
     3001 tgacaggtgc cgatgattat atgatcaaac cattcaatcc attagaatta gtagctagag
     3061 tgaaagcttt attacgaaga tcatctttcc aaaatgctac ttcgcaaaag aatgaagatg
     3121 gtattattcg tattcgctct gttgaaatac acaaacataa tcatactgtt aaagtaaatg
     3181 gagagtatat taaactaacc tctattgaat tcgatatttt atatttactt gcgagtaata
     3241 caggaagagt atttagttca gaagaaattt tcgaacgcgt ttggaatgaa gatggttatg
     3301 gttcaaataa gacggtaatg gtccatatta gcaacttacg ggataaactt gaaacggtaa
     3361 tgaatggaga aaaatttatt cacactgttt ggggagttgg ctataaaatt gagaaatgaa
     3421 gcatttgata tattaaaaga tatccctaaa tggaaactta ttttttggct cttactagct
     3481 atcacactca ctcctattac tgaattaatt atttatcgcc tcgttacgag tgtaattgaa
     3541 agttcactta ctctaaccga gctcggtaaa gaattcattc gaatttttgg ttatgaaaag
     3601 tataaagggg ttaaagaatc tttatggatg atgattgttt cttatttgtt tttattttct
     3661 attttttcat cctatcttta cattttttat cgtcacgaga gaaaacttta ctatgaaact
     3721 tgtataaaaa aaatgataga agaaattcgt tacattgcaa atggaaactt caatcataaa
     3781 gtttctgttg taaatcataa ttatttggaa gagttagcaa tcggggtcaa tgaaattgtt
     3841 gaacaattaa aagtctcaat tgatgaagaa agacaagcgg aacaagcaaa gagtgaactt
     3901 attacaaatg tatcacatga tttacgtact ccccttactt ctatagttgg atacgtaaat
     3961 ttaattcatc atgataatta tagagatgaa gtggaattgc gatactatat tcaagtcatt
     4021 tatgataaag taactcgtct taatgcatta atgaatgact tgttcgaata tacacgtgtt
     4081 caaaataaag agttaagctt gtattctgtc cccattgata ttgtagagtt acttggacaa
     4141 ttaactgttc aattccgaat acaggttcaa gaagctaata tagaatgtag accttctttc
     4201 ccatctcaaa agctcatggt attagctgat ggtgacaaat tagtgcgtgt gtttgaaaat
     4261 cttattataa acgctatcgc ttatggaagc gaaggtcgct atattgacct tactgcttat
     4321 gaaagcaata atatgattac aattgatata acaaattacg gacaacctat tcctagtacg
     4381 gatttacctc atatttttga acgtttttat cgcgttgaaa aatcgcgctc tacaaacact
     4441 ggtggatctg gacttggatt agcaattgca aaaagtatag tcgaattgca taaaggaaca
     4501 attgaagtat atagtgatga cgaaaaaaca actttcactg taaaactact cccctacaaa
     4561 ggttaatatc acaaataaaa agttcaattt cttatcatat aagaaattga actttttcca
     4621 ttaattacaa aaaattaata atcctttata attctttaga aattctttac cttttctttc
     4681 ttcctaatta agcattcttt tttacaatac tattattgat gtcataatag gaggatcgct
     4741 tatgcaattc ttaaaaaaat tcgctatttt attattatct tttttcatta ctgcacttat
     4801 cgttttatat ttttaccttt atgtaaatgg tccgattatt caagctaaat cagctatctt
     4861 aataaatgct aattcaggtg aaattgttta taaaaaaaat gaagaaactc cagtacaatc
     4921 agctgcttta tctaaattaa tgacagaata tatcgtattg gagcaactaa atgatagaaa
     4981 aatacagtta gatgacttcg tacaaataag taacgaagta ttccgagtag aaacaagccc
     5041 tatacaagta acatcgaatg ataaaacaac ggttcgtgat ttacttcatg cattgctact
     5101 ggcagggaat aatcgttctg cactcgctct tgcagaacac attgctggaa atgaagataa
     5161 ctttacagta ttaatgaata aaaaagcaaa agaactaaag ttattacaac catctccatt
     5221 tctaaactct actggaatta ataatgatac aaataaacaa tcaactacaa cagcaataga
     5281 cgtagctaaa ttagcagcac gattaataaa agattttcca gatgtattga atattacgaa
     5341 actaacctct taccaatttt ccttcaaaga ttcccaggtt ttcaatacga ataaaatgat
     5401 atattccctt aatgaaaaca ttaaacttca aggtgttgat ggcttacaaa ctagtttttc
     5461 aactaatggt aattatagtt ttgtcagtac agcaaaactt gaagatacta gactaatttc
     5521 agtaatatta gatgcagatg aagaaaacat ttcatttatt gaaacaaaaa agttgctaca
     5581 gtatggtttt gatccttcct cgtactctgc actccaagct tttaaagaca cccttacatc
     5641 gtggacaata ttgcttcagt ttaaaaattt aattatacaa actataatga tttttttaat
     5701 cattaccacc ttaatgtttt tacatatacg tcagaaaaaa tccgaggatt tcaattaaga
     5761 aatcttctta tatataaaaa ccgacttgcg tttgagatgc aagtcggttt ttaattctat
     5821 tatcctcttc caattaaatt tgctgaaact ggttgcaagt ttaactgcct cgcccatata
     5881 gacagctgac caatatgatg aatttcatat cccatgtctt aaaacctatg tttttcgagg
     5941 catacaccca tctctgtttc cgttcattgt gttcgtttgt ttagtttaaa tgggttaatc
     6001 tattaattct attaaatcca acaatttaac tattacatat taaagttcta ttcatatact
     6061 atagtagatt actagaaagg aggcttaact atggatagtt gcgttgtatt tgtaaacgga
     6121 caaccttttt tagttctttc agtagctggt attgaaattg ctagattaga gatttccctt
     6181 caagtagcat tagctctaag agtgcttggg ataccaatct gtgattaatt accaaattaa
     6241 taaaaaaaga gggcattagc cctctttttt tattttcttc tcaccttttc ttaacaacaa
     6301 acaaaattca aatttgatta attataaaaa attaaagtac atgaacgtta catgaaacac
     6361 ttgttaagat cgctgtcctt cacactattt atttcgccga cattatataa tcaaagcaca
     6421 cgatgattaa ctttttatac ggcttatttt aagtgtgcta gccaatactt ttacttgtat
     6481 gttctataca ctcattctct acggtatact gataccaact tatatttttt gatgagagcc
     6541 catttcccta tatccctctt tattcccatg cacttttttc tcaaatccaa gctaaataat
     6601 ctatattgtt atcttttaaa ctcgcctcac tatccgatta tattaataac ctatcacctg
     6661 gtaaccatta tctaatttat cttcaattgg atggtccatc atttatactt acggattggc
     6721 tttcccgtat ctattgtgca tggacattag gttttctagc atctagctca tttctttaaa
     6781 aatgtagggt atttcgtcta ttattaaatg aataatgttt ggaagggtga tgtaatatga
     6841 cagaaattaa agtagggctt acacaatttt tagacttcac actgaaaggt agtacagcta
     6901 aaacaaactt tataaaaaat ctaaaatccc aacctgaata tcaaccagct tttgattact
     6961 ggaaacaatt acgagaaact gttattaaat ttcatcaaaa caaactacct tttgaatgtt
     7021 tcgaaacatt agtacaaacg gttgatcaga aaaaaaaaca aaactacatt gatgttataa
     7081 agcaatacaa aaaattcatt aaaaataaag acatctcctg gtttgatcca ggtaaatcac
     7141 attggaaatc agatgattta atcgtccgtt catcacctga acttggctta ttcattaata
     7201 atgagccaca tcttatcaaa ctgtttttca aaggaaaaaa agagcgaatt gataaataca
     7261 acattaactc gacacttaca ctattaaatg aatcaacatt ttcaaatgaa cgaaacgatg
     7321 tgaattatac ggtacttaac atccaaaaga acagaatgta tacgaataac tctattaata
     7381 ataatcattt agtagcgctt aaatcagaag ctaaccagtt ttgttacata tggaataatc
     7441 tgtaaagttt actattcatc cctttcaata ccttgttgat gcatacttta gttacaattt
     7501 ttacagattc attcagtttc gtttaattag ggctcaccct cttattcctc agaaacaatg
     7561 caggtgggcc tttttcaaaa atggtttctt tgtcagtttt aatatactag ctctccccct
     7621 gaaacagctg caattgaaat tatttttgtt ttattatcca ctatacccac caagcccctt
     7681 ttgttaacat aatataatta taaattacta ttgttgctac ttcttccatt catattctaa
     7741 catactcatt tcccataaat tccaatacgt ttctcctact ctttttgact ctcttaataa
     7801 gccttctttt acaaacccta ttttttcgta acagaaaatg gccgatgtat taaaatcgta
     7861 cacaccaaga gttaccctat gtagttttaa ttcgtcaaaa gcaatatgaa gtactgcttt
     7921 catcatatgt tttcctatag aacgtcctct catcttcgta ttaccaacta atacttttcc
     7981 aattctagcg gacttattaa tattatctat ttgcccaagc gaaatatgac caataacgtc
     8041 tgaagtcact tcatctacca ctttgaaagc gagtgtattt gcactttcta tatacttctc
     8101 taattgctgt tcgtctaaag ggaatgtgaa tgcatttcct gaccattgta ttagaaattc
     8161 ttcggagtta atccaattta ttaattgttt aaaatcagat ttcttaaagc tttctagttt
     8221 aatcacttcc ttgctccttt catacatcat gctttataac ctcaaactta tttctatata
     8281 aagaatatat tctcctttta tatgaaatta aaataaagcc attcatgtga atggctttac
     8341 aaaaaagcag cataattatg ctttgtttgc tacatcaata ccattaaaat caaagtcagc
     8401 agtaaccgtt gtaacaggtg ggaaaattgc ttcaatttta caaatggaaa taattactcc
     8461 aaccgatcca ggaatagccg caagcctaac tagatcacaa cttacagacg aaacagtacc
     8521 tacataagta cgtccctctg tattaatttg aactgttcga ttaattaatt tcttaagttc
     8581 atctctaatt ccttgtacac aagaattatc acatttctca tgctgttctt ttttacactc
     8641 ttcgaatact tcccaacaat catcttgttt acatgtacac ttctttttac aattattaaa
     8701 tcgagaaccc aatacctcac cccctaatcc tttctattag taaagtatgt ccactagctt
     8761 aaaagggtac gaggcaaaca cataaaaaga aaaaaaacaa acaattgtac tatactttct
     8821 tttcattatt cattataaaa acagacttct cctaattaaa agcttgttta atgagcggcc
     8881 gtgaatttag tcctactcca tttaatgttt agacaccact ttctaaaaca aatctttttt
     8941 cttttaaata agacgctcct taaaaacaca ctagattttt ccattaactc acatatacat
     9001 agactttatt tgtggatttt tcctttgtta ttgtgaaata tacatttaaa aaagcgtact
     9061 cgaaaataag atattatttg taatcagaac gctttcttca acaaatgttt attggaaaac
     9121 accataacta gtagtagttc tctccactat ctcttaaaaa ttagcatggt ttgtatgaac
     9181 tctatatcga gtagaaaaca ctctatcata taaagataaa atagtaggtt aataaacaag
     9241 ccattttttt attaaaacat agaataatat gaacactatt gaaaggaggt agaaatgaat
     9301 gtcttggaaa aatgattgct ggagttctca gaaaaagcat tgttgtgatg attggtggaa
     9361 atctaaagaa aagcatcatt gtgatgatga ttggagttct cagaaaaagc attgtaatga
     9421 tgattggtgg aaatctaaag aaaagtgtca tcgtgacgat gattggtgga aatctaaaga
     9481 aaagtgtcat cgtgatgatg attggggttc taaacgaaat aagtgtcgtt gtaaatgttt
     9541 ctttatttgt tgccattgta aaagaaaaaa ttggtaattt ttttaatgtc aacgtaaagg
     9601 aaagaatatg gcttttggaa ccaatcgggc ttttccggaa agttaatccc acacctactt
     9661 ccttactttc gctgaatttt taggtggggg cattactgcc cggcaaatag tgaaataaat
     9721 actagaatgt aatatataaa aagctgactg agtatagtca gctttttata tattaacacg
     9781 taaaagtttt aacagacata taaagcaggc acgctttgtt atcaccttgt tgtaaattag
     9841 tatttctcca ttgagtagac attccataat atcgtatttt gattaaaact ataaaacata
     9901 cttaacacta atagtagaat ttttcttcat caacttcact ttttctcttt ttataaacat
     9961 aagaaaggat ctctatttat atagagatcc tttcttatgt ttataattta ctagactgta
    10021 acccctgaat aaacggaact acttcaggat ttacaagtga agacaaatca cctaattctt
    10081 ttcctaaata agctgcttta ataacacggc gcatcacttt agaattacgt gttttcggca
    10141 aatcttctac aacgtggatg tctttaggac acaacgcttt tccgatatga gagtttacta
    10201 aactcattaa ttctttcttt aattctcctg tgaatgttac atggtctctt aatactacga
    10261 aacaatgaca aacttcacct tttacttcat caggtacacc aattgcagca gcttcgatta
    10321 catcgttatg tttcacaaga atagattcat attcagcagg tccaatacgt ttacctgcaa
    10381 tatttaacgt atcgtctgaa cgccctgtga tgatatattg ttcaccatcg taaatgaccc
    10441 agtcaccgtg gacccattta ttttcaaaac gcgaccaata tgtgtttacg taacgttcat
    10501 catcttccca gaagcttttc gtcataccta cccaaggttt ctctaagcat aattctccga
    10561 cttcatctcg aattggttta ccttgatcat ccagtacgac agctgccatt cctggtaaag
    10621 atgcattaaa actaatcggt gctattggct taataagaac attaccgaaa atcccaccag
    10681 agatttcagt tccacctgag tagttacaga ttggtacatt tccttttcca actgtttcaa
    10741 acagccacat ccatggatca ggattccaag gttctcctgt tgatgcaaat acttccaaac
    10801 tctttaaaga atgtttattg acatacttat caccttttgc cattaatgct cgtattaacg
    10861 ttggtgaaat acctagatga gtaatttcat atttatcaac tgtctcccat aaccggtctg
    10921 cttctgggaa gtctggaaca ccttcgtaca taaccatcgt tgctccatta atgagtgaac
    10981 cgaataatag aaatggcccc atcatccagc ccatatcagt tacccataat acacgatcac
    11041 cttgtttaat attcattcca aatcctgcat caaaagctgc tttcaaagga aatcctgcat
    11101 gcgtgtgtac tgttcctttc ggcttaccag tcgttcctga tgtataaatg agcattaatg
    11161 gatcatcact ttgcatttct tcggcatgta tgaatggttt ttctttttct agcgtactcc
    11221 acgaaaagtc atagttatgt ggtgtaaaat catttcctgc atgacgaacg attaccactt
    11281 tttcaacagt tgggcaatgt tcacaagctt tatctacttc atcttttaaa gaaacaattt
    11341 ttcctcggcg tgaaaatcca tctgcggtaa taatcatttt tgaacctgcc gcttgcacac
    11401 gtgtcatgac tgcatcagac gcaaagcctg agaatattgg tgaaataatt gctccaattt
    11461 tcattacagc tagcatcgca acaactgttt ctggaatcat cggcatataa attgttacac
    11521 ggtcaccttt ctcaataccc gcgtgtttca aaccattggc aacacggctt acccagttat
    11581 caagctcttc atatgtaaat gattttgaag ttccattttc tccttcgtac tgaagtgctg
    11641 gctgtattct tgtctcttca tccgcaagcc agcgggataa agctgattct acaacgttac
    11701 atgttccgcc attataccac tgtgcaaacg gtgtaccatt ttctaaatct aacacttctg
    11761 tataaggttt catccattga tagccaactg ctttttctgc ctctccccaa agccaagctg
    11821 tttcctcaat agatttatta taaaaagttt catagtcttc atatcccaat gatttcatcc
    11881 aactatataa acgtgttttt tccttgtact cttctgttgg aaaccaaact gcttgtttca
    11941 atgttttccc ctccttaact ttttgagcaa gaaagcccta aatagggctt ttaaactgga
    12001 tatacaggat gtttacgatc cgtgaatact tgatatttac tcatatacat ttcgaaacgt
    12061 ccttttaact cttcacgtaa attgtttgga tgaacaatac catcaatcac catctctgat
    12121 gctaaatgat aaatatcaat atctttctta tactcttcac gtttttcagc aatgaagcta
    12181 gcacgctctt cttctggtaa agctgcaatt ttatttgcat atacagcatt aaccgcagct
    12241 tctggaccca ttaccgcaat agaggctgtc ggtaatgcca aacagcaatc tggttcaaat
    12301 gctggacctg ccatcgcata taaaccagcg ccatatgctt tacgaacaac gatagaaatc
    12361 ttcggtacag tcgcttcact cattgcagaa atcatttttg caccgtggcg aataatacca
    12421 gcacgctcta cttttgtacc gatcataaat cctggtacat ccgcaaggaa taataatgga
    12481 atatgatatg cgttgcataa attaataaac ttagcagctt tatcagctga atcatggaat
    12541 aatacgccgc ccttcatacg cggctgattt gcaataatac caactggctt accatcaata
    12601 cgtgctaagc ctgtaattag ctcttgagca aataattttt ttacttcata gaatgaacct
    12661 tcatcaataa ctctattaat gagatctttc atattgaaag gagcattttg attttctgga
    12721 atgatttgtt ctaacgcttt atcgaattgt ttcggttctt ggggtgtaac caatggagtc
    12781 ttttctaagt agttatttgg aaaatatgaa atgtattgtc ttgcttgtgt aatcgcatct
    12841 tcttctgtct tacataaaac atctccgcat cctgatacag agcaatgcat acgagctccg
    12901 cccatctctt ctaaagttac cttctcaccg ataaccatct cagccatacg aggagatcct
    12961 aaatacatag atgcatttcc ttctaccatc attacaacgt cacaaaaggc tggaatatac
    13021 gcaccaccag ctgcagaagg tccaaataac aagcatactt gaggaacttt acctgataac
    13081 ttcacttgat tatagaagat tcttcctgca ccgcggcgcc ctgggaacat ttctacttga
    13141 tctgtaatac gtgctccagc agagtcgact aaataaaata acggaacacg tagtttttca
    13201 gctgtttctt gaatacgtaa aatcttttca actgtgcgtg atccccatga tccagctttt
    13261 acagtagaat cattggccat tacacacgca gtacgaccat gtattttacc cgttgccgtt
    13321 acaacgccat ccgcaggtaa gcctgtttgt tcacagttag caaataatgc atcttctaca
    13381 tattcgccat tatcaaatag aagcgctaaa cgatctcgaa caaataattt tccttttgct
    13441 ttattttgct catgatattt cggtgccccg ccttgtttaa ttgtttcaac tcgttcttca
    13501 aatgaattag attgttgttt ttggtctaac atatttactc ccccttatac atcggtttgc
    13561 gtttttcttt gaatgcctgt aatccttcta ttcgatcttt cgtatggatt acaccttcat
    13621 acgcttgttt ttccatttgt aatccggtat gtaaatcaac ttgaatacca tttgaaattg
    13681 cctcttttgc taatcgaaca gcaatcggtc cattactagc aattttctct gctatttcaa
    13741 tcgctttctc ttcaagtaaa ttagctggta caacaaattc tactaaaccg tattcttttg
    13801 cttcttgcgc tgaaatacgt ctacctgtat aaattaattc tttcgctcta ccaacaccaa
    13861 ttaatctcgg taagcgctgt gtaccacctg ctcctggtat aattgcaagt gtcgtttcag
    13921 taagaccaag acttgcagat tcagcagcaa ttctaaaatc acaagctaaa cttaattccg
    13981 taccaccacc aagtgcaatt ccatttatag cagcaataac tggctgtggt aattgttcaa
    14041 ccatctccat agtagtgcga atcatactaa cagcatggcg aacttgttct tcattcatat
    14101 cggcacgctc ttttaaatct gcaccagcac aaaatgcttt ttcaccagca ccagtcaaaa
    14161 taactacacg cacgtttgaa tcttcactta tttgagttaa tatagtttgt aattcatcta
    14221 ataatgctaa agataatgag tttgcttgtc tttcacgata taacgaaatc tttacaacgt
    14281 gaggtgttac ataatcaact gaaatgtttt gtaattgtag catcttctca cctacttatc
    14341 gttttatgtt gaagcgctct atacacatga ctcggtaatt ggatatttaa tttactttga
    14401 ataaattgac ttgctctcaa taacttctct tcatcaatat tcgtttggac tcctaactta
    14461 tggagcatat gtactaggtc atcagtagca acattacctg atgctcctgg tgcataaggg
    14521 cagcccccga gtccaccaca agaactatca aacgttttaa taccgtattc taatgattta
    14581 actacattcg ctagagccat tccatacgta ttatgaaaat gcattgcaaa ctgcgaagca
    14641 tcatacttct ttaatagatg ttctaatact tgttctactt gtaatggatt cgctacaccg
    14701 attgtatccc caagagaaac ttcataaatg ccgtatgaaa atagttgatt acataattcg
    14761 tcaactgctg tgacacttat atccccttca taaggacatc caaatacagt agaaacatag
    14821 cctcttacct ttttcccttc gaataatgcc tgttttgtta tatcttcaat tacaactaat
    14881 gcttctttaa tcgatttatt aatattactt ttattatgag attcacttgc tgataaaaaa
    14941 acattcacct catctacatt ttgcaaaaaa gctcgttcca aaccattttg attcggaaca
    15001 agcgcggcat atgtaacatt tggatccctt ttcagctcag aaaatacatc atttgcatct
    15061 gctaatgcag ggacccattt tgggtgaacg aatgaggaaa cttcaacata cgacaatcct
    15121 gcttctgtaa gtagttgaat ccattttact ttatcttttg tgccaacaat ctttttttca
    15181 ttttgtaagc catcacgtgg cccgacttct ttaatgacag caaaattagg tagtttcaat
    15241 tcgcttcccc ctatatctcc ctattcaatt tctaataata catctccttc atttacaaaa
    15301 tcgccttctt gcacattaat tttcataact gtgccagctt cttctgaaat gattggaatt
    15361 tccattttca tagattccaa aatgacgaca tcctgctctt cctctactgt atctcctact
    15421 cctacaacaa tcttccaaac gtttcctgcc atcgatgcgt atactttcgt catcattttt
    15481 tcccccttaa tattgttaaa tcttattttt taacgagttg tttcgttaca aaccccgttg
    15541 tataaatacc ctctttgaac acttcgtcct ccaaaacttg cagtagcatt ggcgtgttcg
    15601 ttttaatacc ttctactttt aattcttcta gagcatcatg taatttcgaa attgcttctt
    15661 cacgagtctc gccatgtgca atgactttcg caatcattgg atcatagaaa ggtgtaatcg
    15721 ttacatgatt ttctaagaag tgatcaatcc gtacatttga cggtaatgtt aaatctgtaa
    15781 ttttcccagg tgatgggaag aatgttttcg gatcctctgc ataaatacga gcttcaatgg
    15841 catgaccact acgttttaca tcatcctgag taaatgatag tttctctcca cttgcgataa
    15901 ggagttgctg ttctacaagg tctaatcccg taatttcttc tgtcactgga tgctctactt
    15961 gtaatctcgt attcatctct aagaaataga agttcttctg atcatctaca agaaactcaa
    16021 ctgtacctgc atttgtatag ccaagtgctt tggcagcttg tacagcaact tctcccattg
    16081 cctttcgtgt accttcatct aaaaatggtg aaggtgcttc ttcgattact ttttgatttc
    16141 ggcgctgcac cgaacattca cgctcccata aatacactgt gttaccatgt gtatctgcta
    16201 aaagctgaat ttcaatatga tgcgcgtctg ctatatatcg ctctaaatac atttctccgt
    16261 taccaaaaaa gttttgcgct cttgttttat tactttcaaa cgctttggtg agcgtttgct
    16321 cagtttccat caactgcata ccaatgcctc cgccgcctgc ggatgcctta agcattaatg
    16381 gataaccaat ttgttttgca atttcaattg cttcttcagc agtttcaata ttcgtagtaa
    16441 tacctgggac tactgggaca tctgctgctt gcattgcgat acgtgattcg attttacttc
    16501 ccatcttcgt aatgatttct tctgaaggac cgataaatac gattccttct tctttgcaac
    16561 gaaccggaaa agacggattc tctgataata aaccataacc tggatgaatc gcttctgcat
    16621 ttgtcttctt agctatttca ataatttttt caaggtttaa ataactttct tgaacacgcg
    16681 gtccacctac taagtaagct tcatttgcca tcttcacatg aagggcattt tcatctgctt
    16741 cagaataaat agcaacagtg cgtatgccaa gtttttgaca agttttcata atacgaacag
    16801 caatttcccc gcgattcgca attaatattt tttgaaacat agtgattcct cccttttatc
    16861 tacatcctaa atgtctagca attacgagac gttgaatttc agaagttcct tcaccaattt
    16921 ctaatagttt cgcatcacga atatgtcgtt caacttcata ttcacgcata taaccatatc
    16981 caccatgaat ctgtactgct tgattcgcaa tacggcttgc tgcttccgat gcaaatagtt
    17041 ttgccattgc cgcttctttg ccgaaaggtt tatcgttatc ttttaaccaa gctgctttat
    17101 gtactaaatt gcgtgctagc tctacttcag tcgccatatc agctaattta aattgaatcg
    17161 cttggaaatt agagattgac tttccaaatt gttgacgttc tttcgcatat tgcaatgcac
    17221 gttcaaaggc tgattgcgca ataccaactg ccaatgctgc gattgaaata cgccctccat
    17281 caagtgtata taaaaattgt ttaaaacctt tatttacatc accaagaata ttttctttcg
    17341 gtacacgcac accatcaagt acgatttcac aagtattaga agcacgaaca cccatcttat
    17401 cgtatggact tgaaatcgtt aatccttcac tagtagtagg cacgataaat gcagaaatac
    17461 gttttctacc attctcttca acgccattga cagcggttac aataattgta tttgcatact
    17521 ctgcgtttgt aatccaacac ttctcaccac tgattacata ctcatcgcca tctaataccg
    17581 ctttcgtttg agtaccacct gcatcagatc cagcattcgg ctccgttaat ccgaaggcac
    17641 ctaatgtttt acctgacgcc attggaacta aatacttttg tttttgttct tctgtaccga
    17701 aataataaat tggagaagca cctaatgaaa ttgttgcagc atagcttaaa ccggtgccac
    17761 cacaagcgcg accaatttct tcaactgcta aagcatacga tactgtatcg ccacctgaac
    17821 ctccatactc ttctgggaat gggatgccta gtaatcctag ttcgcccatt ttttgaaatg
    17881 tttcatatgg aaactctgca gttttgtcat aatatacagc tttcggtgcg atttcctttt
    17941 cagcaaagtc acgtaccatt tctttaatca tttgtttttc gcgagttaga gtaaattcca
    18001 ttccgctaca caccccttat cgaatattga gtttcgacag cgtgcgagtt tctactacaa
    18061 acataacaac ttaaaagaca agaatattag ttagacaatt gctataattc tgtcataact
    18121 taattttaaa acagattctg tactaatgca caaaaaaatt cctacattgt tctacaacaa
    18181 cataggaggt tttgtgtcga attatgtaat ttattgttta ataatctcta ccttttccgg
    18241 aatcagaaat ttctactaat gcttcaggat atggttcgaa atatgtttgt cttaataaat
    18301 acttttcatc aaatcgaata gcccatgatt ttaaaattgt aagtaaacta ctaagtggta
    18361 ttttcttttc tgcatacttt tgtaacagtt ctataaaatg atctttttct tgttttttta
    18421 actttgtttt aaaatatcca aaaatgtgct cgcatacatt tacattcgat gtataacggg
    18481 gcgcacgcat aaataattca tataaagtct tctcatagtt ttcaaatacc acttcaatct
    18541 tttcattttt ttgatttgca attatacgac ctaattcctt ttgtttcacc tgattatatg
    18601 ccataaataa atatttatta tccgactgaa acgatacaag ttctttcata tttttattgt
    18661 gtttaatcat tttgtaatat gcgattgtaa atagccttgt aaagaaatgc tctctaataa
    18721 taaaattcga caatctacct tcctcttcaa taggaagatg cgaaaatttt tttactactg
    18781 ctccgccaaa taagccagct ccttttccct ttgctggcgc tttttcaaaa ccagaataaa
    18841 ttttcacatc acgcgtacca caacttggtg aacgattctt taaaataaaa ccatccacat
    18901 ccggtatcgt ttgtaaaaag tcatttgaaa actgctccat tttttcagtt acatcttctc
    18961 gtgtcgacgg ttgcacaagt ctattctcac cattttcttc tacaattcgt atcgtttcac
    19021 gaggagtccc caatccaatc tcgacttctg gacaaacagg tataaatgta acaaatggct
    19081 gcaaatttcg tattgttaca tctggaatca tctctccatt ataacgacaa gcatcaaatt
    19141 ctaaacattt acttacgacg attgtaggtt ttgcaaattg tcgcatctta ttacctcctt
    19201 attactagtc cgtataatat aaattgtact aagattaaca ttttaagcaa agtttgattc
    19261 agttattttt atgagaaata taaatccaat gatacattaa caatcattca actctatttt
    19321 ctataaatgt gcgccctatt aatgagggtt tagatattgt gaaatgaata atacacacat
    19381 gcttcggaga aattaatgat taagaaagga gggattgtta tgaaaaagaa attatcatct
    19441 attttaagtg ttttaacact atctattatg tttttaggta catctacgca agctgaatac
    19501 gatggaaata atatgaatag agttaataac actgatattt caactcgagt aaatgacaat
    19561 aacttagaca gagttaataa tgatgtaaga actcgaaatg taaatacaac aaatgattta
    19621 aatgataatc gtgataaaaa taataattgg gcttggcttg gtttattagg actagcagga
    19681 ttattaggtc ttagaagaag agacaaagaa acacgctgat ttagaatgtt tttagtaaac
    19741 aagcacttat ttatcaaaaa tatataatga aaataaatcg cctttttaaa ggcgatttat
    19801 ttttacttaa aagtaatgta tgtaattcac acttcaacga ttaaattcgt ggagttaatc
    19861 catacaatat aaattgaatc gtattttcaa tttccgcttc atcattccat ttttcttcag
    19921 gcaataataa aaatcgtgtt aataataaac ctaatacagc tgataaagta agacgtagta
    19981 cggaagatgg tggtatctca ataatttccc cttcttcttg aaatttcaca atcaactttt
    20041 tgaaatgtga aaacagttct gtttctacta attgctgtat ttcatttttc agttctggtt
    20101 ggaatggcac ctcttgaatt aatattttta tcataggaaa gtgtttttga gcaaatttaa
    20161 acctattatg aattacaacc cttaaaagtc cttcgtatga ttcatactcc gatttaaata
    20221 tttcttttgc aaaggtttgt acgaaaaatg gtgcagcgaa cttagttaaa gttggcatta
    20281 cgaccgctag taataaatct tttttcgtct tatagtagcg gaagattgtt ccttccgcta
    20341 caccagcccg ttttgcaatt tcacttgttg aagttgaagc gtatcctttt tctccaaaca
    20401 tatcaacagc cgcctctaat attcgcattt gacgttcatt tcgtttatcc gtattagttg
    20461 cagctattaa ttcctccagc caatccttct gcatttataa agctcctttt tgtcattatt
    20521 atattttgcg atgtttcttt aaagcaaata catttcctac tgcaaataat attgaaaaaa
    20581 gtaataatac agtaagatct aatgcaatct ctgtaaaccc ttgattccga atcatcactt
    20641 gtctcattgc gtcagcgccg tatgtgagtg gaaatacttt ccctaacatt tgtagccact
    20701 tgttcataga ttccattgga aacaatccag aaaagaagat ttgtggcaca ataacaagcg
    20761 gtataaattg aatcatttga aattcattat ttgcgtatgc cgataaaaac gtacctaatg
    20821 ttagtgcagt taaagagagc atacatgtaa taagtagcgt tagccatata gagccaacta
    20881 cgtataaatc taaaatataa acggaaaaac ttacgataat aatggattgt ataaaggcaa
    20941 agattccaaa accaataata taacctgcga ctatttccca tcttcttatt ggggtggata
    21001 ataacctttc tagcgtacca cttaaacgtt ctcttacgaa ggatacacct gataatataa
    21061 atacaaagaa aaatgtaaag aaaccaatta atacaggacc aagcccatca aacatcgtaa
    21121 agtctttaga gccatgtaaa aaattcactt caggtttcat aatcgataca tcattcttct
    21181 ctgtgctttt ttgcaatact tgaagtacag cacgattttt tgacgaatca ctaccttcca
    21241 acagaagttt catttttcca ttctctattt gaagtattgc atctaccttt tgtttttcta
    21301 actcagaaat cgcgtttact ttactgtatt cataaattga cgcttcttga tttttcatca
    21361 cttttactat ttgagcgggc atatcaacaa cagcaatttg cggtatatag tctttttgtg
    21421 taaacactag cgataatagc caaagtaata acattggtgc cccaaacatc atcgctaacg
    21481 aacgcttatc tcgaaaaaat tggcgaataa tacgaatgat tacaccagta actctcatga
    21541 tgacaccacc tcttccaaca aaaagacatc ttcaatccgt ccagatgaca cgcgtttttt
    21601 caattcttca gttgttccaa ccgcaactag tttcccttct ctaattaatc ctagacgctc
    21661 acaaaattca gcttcatcca taatgtgcgt cgttacaata atcgttgtgc ctttcttttt
    21721 aagatcataa aatttttccc aaatcgtttt cctaagaagc ggatctatcc ccactgtagg
    21781 ctcatctaaa attaatattt ctggttcatg gaggagtgct attgctaatg ataagcgttt
    21841 tttcattcca cctgaaaatt gttgtacttg ctttttcata tactgtgaca attgtacaag
    21901 ttcaaaaacc tctgcaattc ttgtcttttt actttttccc tttaatccat acatcgttgc
    21961 tataaaatct gcattttcat atgctgacaa ttcttcatat aatgcatccg cctgggccat
    22021 ataaccaatt cgtttcattt catttaaatt aggcatatta gtattattaa caagcacttc
    22081 acctttcgtt gcctcattaa tacctgcaat cattttaatg agcgttgttt tccccgatcc
    22141 agaaggtcca acaaaaccaa aaatctctgc tttttcaact tgcaatgaaa gattgtgtaa
    22201 cacttctttt tttccaaaac tttttgatac agtccgtaaa ataattgaag gttgttgcac
    22261 gtttcatcgt ccttttccaa taaaaatgag tgagtactca cttttatttt actcttgctt
    22321 aattatatgt caaacttcgt tgattagtat gtatgttcaa tcaccgatat taaaaaatga
    22381 aacagagtcg acattagaat ttcatttcct aaagtcgact ctggttcatt taaactataa
    22441 atttcacttt acgtttttaa attcatatac ttccgaattc tagcaacgtc taaagaatat
    22501 tcgataacta attgctgtaa cggtaaaata actgtgtcag gatataaatg tgcatattgt
    22561 aatgtttctg catatttttc taaccttttt tctaaatact ttattatttg atcaggatga
    22621 cttactaata aacatttaca ataataatgg atttgttcct caatcgccgt gtattcttca
    22681 atttcatatt ctttatgcat gtgtacaccc ctttaagttt tttatatgaa ttacttatca
    22741 caattttcac tcgacaaatt ttaagttttt tgattattta cactataaca aacactgagg
    22801 gtcaaatttt gttactttat gtaacgtaga aaatttttaa caaaattgta atgtttactc
    22861 ctgcaaaata cagaaagccc ctttactcat ttttgtataa aaaaaatcgt acagcttaat
    22921 ttagctgcac gactacaatt tctggcctat tcaaaatcct ttgcggaatg atactatttc
    22981 ctaatcctct actcactacc attgatgtat tttgttctac atataaaccc gctgtatatt
    23041 taggtaaaac accttgattt ggcgcaacta atcctccgat aaatggcaat ctaacttgcc
    23101 ctccatgagc atgtcccgat aaaaccaaat ccaacctctc attcgtatat tcctttataa
    23161 attcaggccg atgggataat aatacattat atttatctgg ctgcatttca attttcgctt
    23221 ttttaatttc atctattata atatttcctt catcacggtt tccagtaaca aactctggat
    23281 catcaatacc tagcaagttt atttcttgct caccctttcg aatgcctaca tgttcattcc
    23341 ttaaaacatt gacatcatat ttcttcaact ctttttctaa attgttatac tttccagacc
    23401 attgttcatg gtttcctgtc acaaaatata caggatattt ctttacaatt tctcgtatta
    23461 attgcatact aacttctgca tcgtatgatt tactgtcaat taaatcaccc gtaatcgcaa
    23521 taatatctgg gtctatactt tttatttttt gaattaacac atcttgatta tcgccaaatt
    23581 ttttattgtg taagtctgaa atttgtagaa ttttataccc tttaaaagag gatggtattt
    23641 tactagaggt tattttaacc tcagttatac ttattaaatt gttctgtaaa tataaaaaga
    23701 ttgtaaaacc tactaatata caaataatca ttacgattct attaatcttt tttttcatat
    23761 tttctccttt atattctcat caaacacttc tatatgctaa ctgaattata ttatactttc
    23821 ttgaaattta tttaaattaa taaaataata cagtacagaa aatttcatat gagatacgtc
    23881 atatatattc gttatatttt tacttttacc tttttaataa taagaacaca aaaacgactc
    23941 ttatcacacg aaaagagtcg ttttctaact ttatactttt aatactttta atacttttaa
    24001 tacttttatg ttaaaaatgc gaaaactaaa atactattac ctaagagcct taactataac
    24061 ttccgttgcc tctgcaatga gttgattatc atagctagcc tctttctcat ctttactaga
    24121 taaaattgcg atgataattg gtgctctatt cggaggccaa acgatagcaa tatcatttct
    24181 tgttccgtaa ctgccagcac ctgatttatc tccaactacc cagtcagttg gtacgcctgc
    24241 acgaataagt ttgtcccctg tagcatttcc tttcatccac tctgtaagaa ttttacgttt
    24301 ttcagctgga agtgcatttc cgaccgtaaa agctttaaga ttcgtagcaa ttgctttcgc
    24361 tgtactagtg tcacgaatgt ctcctggaat agcttcgttt aattctgttt caaagcgatc
    24421 agacatagta acccgatccc ccatctttct aagcgctttt tcatatcctt taggtccgcc
    24481 tattttatta aataaaatgt tccctgcagt attatcactt gaacgaacag cagcctcagc
    24541 aatttctcct agtttcattc cagtatctac atgtttctct gtaacaggtg aataatccac
    24601 taagtcttct ttcgtaaatg tgattacttc atttaatgta tcaattgagt tttgctgtag
    24661 taatactcct gctgctaaag ccttgtaggt tgatgcgaag gcaaatcttt cgttagatcg
    24721 ataagaaatt gtttgatttg taccagtatc aatcgcatat acacctactc gagcatcaaa
    24781 ttttttctca agttgagaga actctttatg cgtcgcctga tttttatgtt tcacttgtcc
    24841 agtcttttct ttcgcttcaa cttgcagtgc ccctcctgta aaagcttcta ggcttgtaat
    24901 acttaaacct aatataccaa cgcatattcc tatttttagc atcctcttat ttttcaaaat
    24961 catcattcct tccaaatttt tagcaccttt ttatacgtac acataataga caatcaccga
    25021 accaaatttg ttccataaac taaaaaaatt atagctagta tgagagttat taacaaaata
    25081 agagatagta gctacgacgc ctctatctcc tatttcatat ttcatttttt tacttataaa
    25141 tggctttata tgaacaggtt ctttccctga gaaaagtact ctaattttgc ttagaactac
    25201 ctgtactagt agcttcacca tgtatacgtt gctgtttta
//
