LOCUS       NZ_CP015612            10846 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Stenotrophomonas maltophilia strain OUC_Est10 chromosome, complete
            genome.
ACCESSION   NZ_CP015612
VERSION     NZ_CP015612.1
KEYWORDS    RefSeq.
SOURCE      Stenotrophomonas maltophilia
  ORGANISM  Stenotrophomonas maltophilia
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas; Stenotrophomonas maltophilia
            group.
REFERENCE   1  (bases 1 to 4668743)
  AUTHORS   Dong,H., Rui,J., Xue,C., Li,X. and Mao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-MAY-2016) College of Food Science and Engineering,
            Ocean University of China, No. 5 Yushan Road, Shinan District,
            Qingdao, Shandong 266003, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP3 in SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 123x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002138415.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 21:48:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,285
            CDSs (total)                      :: 4,195
            Genes (coding)                    :: 4,163
            CDSs (with protein)               :: 4,163
            Genes (RNA)                       :: 90
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 32
            CDSs (without protein)            :: 32
            Pseudo Genes (ambiguous residues) :: 0 of 32
            Pseudo Genes (frameshifted)       :: 12 of 32
            Pseudo Genes (incomplete)         :: 20 of 32
            Pseudo Genes (internal stop)      :: 6 of 32
            Pseudo Genes (multiple problems)  :: 4 of 32
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:11:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1213010
            Orig. end                         :: 1223856
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015612.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Strain available from Biochemical Engineering Laboratory, College
            of Food Science and Engineering, Ocean University of China.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10846
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10846
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10846
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5846](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5846)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(56..70)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            459..683
                     /locus_tag="A7326_RS05565"
                     /old_locus_tag="A7326_05530"
     CDS             459..683
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012479411.1"
                     /locus_tag="A7326_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05530"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_088025031.1"
                     /transl_table=11
                     /translation="MAIVITLDRMLQERGMTLSELAGRIDITLANLSILKTGKARAIRF
                     STLDAICRELQCTPGDLLGHDPAKAQDAD"
     gene            727..2268
                     /locus_tag="A7326_RS05570"
                     /old_locus_tag="A7326_05535"
     CDS             727..2268
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014036331.1"
                     /locus_tag="A7326_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05535"
                     /product="TerC family protein"
                     /protein_id="WP_088025033.1"
                     /transl_table=11
                     /translation="MEWLADPSIWMGLATLVVLEIVLGIDNLVFIAILADKLPPHQRDR
                     ARVIGLALALLMRLVLLAALAWIMKLTEPLLTLFDRSFSGRDLILLGGGLFLLFKGTME
                     LHERLEGREHHEDGKKVYASFAMVVAQIVVLDAVFSLDSVITAVGMVDNLGVMYAAVTI
                     AMALMLVASKPLTRFVNKHPTVVVLCLGFLLMIGFSLVAEGLGYKIPKGYLYAAIAFSI
                     LVEAFNQWVRFNRERNERRQPFRQRTADAVLRMLGARPANGHADESVDEQVDAEERLQP
                     AEHEMIRSVLGLADRPVSSVMTVRADVQWIDLARGQEDVVARLVASPHTRLLVGDGDLD
                     SLRGVVQSRDLLADLLQGKPLQLEGNLREPQYVLSSASALQALELIRQHPVPLAVAVDE
                     YGSVEGLVTANDLLAAIAGDLVDTQDERYGVVAQGEDCWEADGALTLDDLQRLAGVSLP
                     RSADYMTISGLVLERLGRLPDIGDAVEIADVRITVLAMEKRRIARLRVERIDGMA"
     gene            2390..3526
                     /locus_tag="A7326_RS05575"
                     /old_locus_tag="A7326_05540"
     CDS             2390..3526
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004147841.1"
                     /locus_tag="A7326_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05540"
                     /product="metallophosphoesterase"
                     /protein_id="WP_088025035.1"
                     /sec_met_domain="Metallophos_2 (E-value: 4.9e-09, bitscore:
                     34.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAVLSTIGLLMGLYVAWRLFWPLRMRIWMKVVLSLLLVGVAVQL
                     RIVATFWGTMASPEIPKLAIATLATGSTAVLVLALVMLVLDAGLLLSHLLRWPRAVAAL
                     RTRRLRPVAGLLALLVSGYGVSQGMAVPKPRQIKVSIVGLPAAFDGYRVLQLTDIHASR
                     LLTGDWVRRVVDESNALTPDLIVITGDLIDGSVEARRDDARPLADLRSPDGVIAITGNH
                     EYYAQYQAWMQAFRALHMQVLENSHLQVRRGDAALTIAGVTDPVAARYGLPLPDLETAL
                     AGADPTAPVILLDHRPRNAREAAARGVKLQLSGHTHGGQIIGMDQLVKRANGGYVSGRY
                     DVDGMTLYVSNGAGLWAGFPARIGVPSEITLVTLRRAP"
     gene            complement(3582..4220)
                     /locus_tag="A7326_RS05580"
                     /old_locus_tag="A7326_05545"
     CDS             complement(3582..4220)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408497.1"
                     /locus_tag="A7326_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05545"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_088025037.1"
                     /transl_table=11
                     /translation="MTISNTSFLHGWRLFVAIGVVLIAFALTAFALYPDAAEGSRAAIR
                     LTARTSFLLFLAAFTASSFATLLPGPFTHFLLRERRIIGLSFAFSHLLHAVAITSFGIL
                     NPAFWPARSALANLPGTVGYIAILALAITSHRGLARRMGPTAWRRLHVAGMWIIAAVFT
                     YSYFKRVPGNFWYAVPSALMFTAFVVRWIAKRAQALRRSAHARPPLRAA"
     gene            complement(4223..5008)
                     /locus_tag="A7326_RS05585"
                     /old_locus_tag="A7326_05550"
     CDS             complement(4223..5008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646320.1"
                     /locus_tag="A7326_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05550"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_088025038.1"
                     /transl_table=11
                     /translation="MAESLATLQRRWADHVRDPSMAAPDGVEARRLAVYRRLCIDSLDT
                     LLAGTLPRLQHQLGTPRWRDTVEHYYASHTCRTPLFPQIAGEFAAWLAMQDALALPAWA
                     AELAHYESTQQSLHIEARAAGRSLHRVPVDSDVLAVSPLVRVLGYQWPVHVDEMLEPVL
                     DAAPTLLLMRRMPEFRLQVEELSPLAYAVLSAFGDDGTRVDDVLQTVAEAHGVAPDELR
                     AASIPVLRDLCTAAVLVASTDPRACRPTAGTAPSPFFEA"
     gene            complement(5001..5846)
                     /locus_tag="A7326_RS05590"
                     /old_locus_tag="A7326_05555"
     CDS             complement(5001..5846)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646321.1"
                     /locus_tag="A7326_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05555"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_088025040.1"
                     /sec_met_domain="DUF692 (E-value: 4e-117, bitscore: 388.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPLPSNAAGLGLRRGLIDELLAMPAGAIDFLEVSPDNWIGVGG
                     AHGTALRRLSERHRLTCHGLSLSLGGPDPLDRTLLAQTRAFLDLHQVQLYSEHLSYCVA
                     GGHVYDLLPLPFTAEAVHHVAGRIAQVQDMLGRRIAVENISYYAVAGAEMSEIDFINAV
                     LAEADCDLLLDVNNVFVNACNNGYDAFEFLARVPAQRVASLHVAGHFDEDDGFKIDTHG
                     APVKGVVWALLREAYARVGVRPTLLERDFNFPPLPELLAEVAQIRQAQAGAHWPEVAHG
                     "
     gene            complement(5903..6379)
                     /locus_tag="A7326_RS05595"
                     /old_locus_tag="A7326_05560"
     CDS             complement(5903..6379)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005412584.1"
                     /locus_tag="A7326_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05560"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_088025042.1"
                     /transl_table=11
                     /translation="MSVSTKTTPSSRLPRVGAIGIALAGGLLLAGQAAAIQPLAVSAMA
                     MSAAAEGKCGEGKCGANKTATGKPAGKAKVAEGQCGEGKCGDASFARTDRDHDGRVSRA
                     EFNAVAAKRAAEFDRIDTDHDGYISEQEAHDYLRSVYTANGKPMPKGLFSRVAD"
     gene            complement(6480..7124)
                     /locus_tag="A7326_RS05600"
                     /old_locus_tag="A7326_05565"
     CDS             complement(6480..7124)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012479418.1"
                     /locus_tag="A7326_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05565"
                     /product="DoxX family protein"
                     /protein_id="WP_088025044.1"
                     /transl_table=11
                     /translation="MISTASSVYTPRLDAVGRWLSPLALRTLLAWEFFESGREKLGGQN
                     WFADLEGRFPFPFSALPASLNWQLATWLELVGAVMLLLGLATRSVAYVFWVLTVVAIAA
                     VHWPDQWNGLGELWQGYAITDQGYGNFKLPLLFLAMLLPLILNGGGALSVDRLLAGSQH
                     APVGNDGLGWGVSLIALLLPVAALLPGIGFGGALLGGVLLVGYVLRRRRNA"
     misc_feature    complement(7228..7246)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            7467..8261
                     /locus_tag="A7326_RS05605"
                     /old_locus_tag="A7326_05570"
     CDS             7467..8261
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408502.1"
                     /locus_tag="A7326_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05570"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_088025046.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.7e-15, bitscore:
                     53.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTTLLAAALALAGAAAPAFAAQVDAGAPPTIILVHGAFADGSS
                     WSKVISTLHDWKLPAVAVQNPLTSLADDVAATRRAIAAAPGKVVLVGHSWGGTVITEAG
                     NDPKVQALVYVAAFAPDAGQSSAQQGEGFPVGPGLTRLQQRDGYLTLPADAIAQDFAPD
                     VMKTSAALLYSTQVPLKASALGEVVNVAAWRSKPSWYVLSRDDRMLSPQLQAATAKRIG
                     AQLQSIGSSHVSLLSHPAQVADSILEAAGVKPAELPLAEQGG"
     gene            8265..8810
                     /locus_tag="A7326_RS05610"
                     /old_locus_tag="A7326_05575"
     CDS             8265..8810
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005415663.1"
                     /locus_tag="A7326_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05575"
                     /product="redoxin family protein"
                     /protein_id="WP_088025048.1"
                     /transl_table=11
                     /translation="MATLRGYALPLLLGLLGGAALLLAWPGADAGAQPLDAAPMAGFDG
                     GGPWHNSSPLTLKQVRGQVVLVEFWTYTCSNCLNVAPHVHQWHVRYASQGLKVIGVHTP
                     EFAYEGLPGNVRRAIARLDITWPVVQDNQYRIWNAWGNRFWPALYLLDRQGRVVYRHYG
                     EGDYAHTESQIQRLLASP"
     gene            8869..9609
                     /locus_tag="A7326_RS05615"
                     /old_locus_tag="A7326_05580"
     CDS             8869..9609
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019659345.1"
                     /locus_tag="A7326_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7326_05580"
                     /product="response regulator transcription factor"
                     /protein_id="WP_049443785.1"
                     /transl_table=11
                     /translation="MNPVPHILVVDDDSEIRQMLADYLQRNGLRVSQADGGRAMRALMD
                     THAVDLVVLDVMMPGEDGLSLCRNLRAGKHRAVPVVLLTARDDETDRIIGLEMGADDYV
                     TKPFSSRELLARINAVIRRTRMLPPNLQVSEAGRQLAFGAWRLDTTARHLLDAQDTAYP
                     LSGAEFRLLRVFLDHANRVLSRDQLLSLTQGRDAELFDRSIDLLVSRVRQRLGDDAREP
                     TYIKTVRSEGYVFSVPVQLLGPDE"
     misc_feature    complement(10698..10712)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.47"
                     /tool="antismash"
ORIGIN
        1 cgcactgctg gcggtgccac tggtcgccca cgaccgcagc tggctgctcg acagcatcca
       61 cgacgctgat gccgctgccg tgcatggcag cgacctgttc ctgcatttct acctgggcct
      121 gggtgccatc gtcgcgctgc tggtgctgtg cctggtgttc ctgcgccatt tgctgcggct
      181 gctgaagtcg gcggcgcgcg agcggccgtt cacccatgcc aatgcacagc gcctgcagcg
      241 catggcgtgg ctgatgctgt cgatggaggt gctgtcgatc ctgatcggcg cctacgccgc
      301 ctggatgggg ccggacttca cctggatgga ggtgggcggc ggcatgtcga tcaccggcct
      361 ggtcgcggtg ctgatgctgt tcgtgcttgc acgcgtgttt gccgtgggtg cggcgatgcg
      421 cgatgacctc gatggtctga tctgatgggc acgcgctgat ggcgatcgtc atcaccctgg
      481 accgcatgct gcaggaacgg ggcatgaccc tgtccgagct ggccgggcgc atcgacatca
      541 ccctggccaa cctgtcgatt ctgaaaaccg gcaaggcacg cgccatccgg ttttccacac
      601 ttgatgcgat ctgccgtgag ctgcagtgca cgcccggcga cctgctcggg catgacccgg
      661 cgaaggcgca ggacgctgac tgagtgcttt cccttttccc ttacctactg acgaaacgga
      721 cctgaaatgg aatggttggc tgacccctcg atatggatgg gccttgcaac cctggtcgtg
      781 ctggagatcg ttctcggcat cgacaacctg gtgttcatcg cgatccttgc cgacaaactg
      841 ccgccgcacc agcgtgaccg tgcgcgggtg atcggcctgg cgctggccct gctgatgcgg
      901 ctggtgctgc tggccgcgct ggcctggatc atgaaactga ccgagccgct gctgacgctg
      961 ttcgaccgca gcttctccgg gcgtgacctg atcctgctgg gcggtggcct gttcctgctg
     1021 ttcaagggca ccatggagct gcacgaacgg ctggaaggcc gcgagcacca cgaggatggc
     1081 aagaaggtct atgccagctt cgcgatggtg gtggcacaga tcgtggtgct cgatgcggtg
     1141 ttctcgctgg actcggtgat caccgcagtt ggtatggtcg acaacctggg cgtgatgtac
     1201 gccgcggtga ccatcgcgat ggcgctgatg ctggtggcca gcaagccgct gacccgcttc
     1261 gtcaacaagc atcccacggt ggtggtgctg tgcctgggct tcctgctgat gatcggtttc
     1321 agcctggtgg ccgaaggcct gggctacaag attccgaagg gctacctgta cgcggccatt
     1381 gccttctcga tcctggtcga ggcgttcaac cagtgggttc gcttcaatcg cgagcgcaac
     1441 gagcgtcgcc agccgttccg ccagcgcacg gccgatgccg tgttgcgcat gctgggcgcg
     1501 cgcccggcca acggccatgc cgacgaaagt gtggacgagc aggtggacgc cgaagagcgc
     1561 ctgcagccgg ccgaacacga gatgatccgc agcgtgctgg gcctggccga tcggccggtg
     1621 tcgagcgtga tgaccgtgcg tgccgacgtg cagtggatcg acctggcacg tgggcaggag
     1681 gacgtggtgg cgcgcctggt ggcatcgccg cacacccgcc tgctggtggg tgatggcgac
     1741 ctggacagcc tgcgcggcgt ggtgcagagc cgcgaccttc tggccgatct gctgcagggc
     1801 aagccgctac agctggaagg caatctgcgt gagccgcagt acgtgctgtc cagtgccagc
     1861 gcattgcagg cgctggaact gatccgccag cacccggtgc cgctggcggt ggcggtggac
     1921 gagtacggca gtgtggaagg cctggtgacc gccaacgacc tgctggcggc cattgccggt
     1981 gacctggtcg acacccagga cgaacgctat ggcgtggtcg cgcagggcga agattgctgg
     2041 gaggccgatg gcgcgctgac cctggacgac ctgcagcgcc tggccggcgt gtcgctgccg
     2101 cgcagtgccg actacatgac catctccggt ctggtgctgg agcgcctggg gcgcctgcca
     2161 gacattggtg acgcggtgga gattgcggat gtgcgcatca ccgtactggc gatggagaaa
     2221 cgtcgcatcg cccgcctgcg ggttgaacgc atcgacggaa tggcttgacc tacctgttgt
     2281 tgtagagccg agcccatgct cggctgcatt ttgagaaggc gagcgcaggc tcggctctac
     2341 acaacacctc tcgcaaccgt caccatggcc ggcccgtttt ctttccagga tggttgcagt
     2401 gctgagtacg atcggtttgt tgatgggcct gtatgtggcc tggcgcctgt tctggccact
     2461 gcgcatgcgc atctggatga aggtcgtgct gtcgctgttg ctggtgggcg ttgccgtgca
     2521 gttgcgcatc gtcgccacct tctggggcac gatggcgtcg ccggagatac cgaagctggc
     2581 catcgccacg ctggccaccg gctccaccgc cgtgttggtg ctggcgctgg tgatgctggt
     2641 gctggacgcc ggcctgctgc tgtcgcacct gctgcgctgg ccacgcgcgg tagccgcatt
     2701 gcgcacgcgg cgtctgcgac cggtggccgg cctgctggcc ctgttggtca gtggctacgg
     2761 cgtcagccag ggcatggcgg tacccaagcc tcggcagatc aaggtgagca tcgtcggatt
     2821 gccggccgcg ttcgacggct atcgcgtgct gcagttgacc gacatccatg ccagccgcct
     2881 gctgaccggc gactgggtgc gcagggtagt ggatgagagc aacgcactga cgccggacct
     2941 gatcgtgatc accggcgatc tgatcgacgg cagtgtcgag gcccgccgtg acgacgcgcg
     3001 tccactcgcg gacctgcggt caccggacgg tgtcatcgcc atcaccggca accacgagta
     3061 ttacgcgcag taccaggcgt ggatgcaggc gttccgcgcg ctgcacatgc aggtgctgga
     3121 gaacagccac ctgcaggtgc ggcgcggtga tgcggcgctg accatcgccg gcgtcaccga
     3181 tccggtggcc gcacgctacg gcctgccgct gccggatctg gagaccgcgc tggctggcgc
     3241 cgatcccacc gcaccggtga tcctgctcga ccatcgcccg cgtaatgcac gcgaggcggc
     3301 cgcgcgtggc gtgaagctgc aattgtccgg gcatacccat ggcgggcaga tcatcggcat
     3361 ggaccagctg gtgaagcgtg ccaacggtgg ctatgtctcc ggtcgctacg acgtggatgg
     3421 catgaccctg tacgtgagca atggtgcagg cctgtgggcg ggttttccgg cgcgcatcgg
     3481 cgtaccgtcg gagatcaccc tggtgacgct gcgccgcgcg ccgtgaccgg aagtgggtca
     3541 gattcctgtc ccccgggggg aagtgatctg accccggccc gtcaggccgc ccgcagcggc
     3601 ggccgcgcat gcgcacttcg acgcagcgct tgtgcccgct tggcgatcca gcgcaccacg
     3661 aaggcggtaa acatcagcgc cgacggcacc gcataccaga agttgcccgg cacgcgcttg
     3721 aagtatgagt acgtaaacac cgccgcgatg atccacatgc cggcgacgtg caggcgacgc
     3781 caggcggtgg gtcccatgcg ccgggcgagc ccccggtgcg aggtgatggc cagcgccagg
     3841 atggcgatgt agcccaccgt gcccgggagg ttggccagcg ctgagcgtgc gggccagaac
     3901 gccgggttga gaatgccgaa actggtgatg gcgactgcgt gcagcaggtg cgagaacgcg
     3961 aaggacaggc cgatgatgcg ccgctcgcgc agcaggaaat gagtgaacgg gccgggcagc
     4021 agggtggcga aggaggatgc cgtgaatgcc gccaggaaca gcaggaacga tgtgcgggcg
     4081 gtgagccgga tcgccgcgcg gctgccttcg gctgcatcgg gatacagggc gaaggcggtc
     4141 agtgcgaacg cgatcaggac cacgccgatg gctacgaaca ggcgccagcc gtgcaggaag
     4201 gacgtgttgg aaatggtcat ggtcaggcct cgaaaaatgg agagggggca gtgccggccg
     4261 ttggccggca tgcccgggga tcagtcgacg caaccagaac ggctgctgtg cagaggtcac
     4321 gcagcactgg aatgctggcc gcacgcagtt catccggcgc gacaccatgg gcttcagcca
     4381 cggtctgcaa tacgtcatcc acacgtgtgc cgtcatcgcc gaaggccgac agcactgcat
     4441 aggccagcgg gctcagttcc tcgacctgca gtctgaattc aggcatgcgg cgcatcagca
     4501 gcagcgtggg agctgcatcc agcaccggct ccagcatctc gtccacatgt accggccact
     4561 ggtagccaag cacccgcacc agcggcgaga ccgccagcac atcactgtcc accggaacgc
     4621 ggtgcagcga acgcccggcg gcgcgcgctt caatgtgcag cgactgctgc gtgctctcgt
     4681 agtgcgccag ttccgctgcc caggccggca gtgccagcgc gtcctgcatc gccagccagg
     4741 ccgcgaattc gccagcgatc tgtgggaaca acggggtgcg gcaggtatgg ctggcgtagt
     4801 agtgctccac ggtgtcgcgc cagcgcggcg tgcccaactg gtgttgcagg cgtggcaggg
     4861 tgccagccag cagggtgtcc aggctgtcga tgcacaggcg gcggtacact gccagccggc
     4921 gcgcctcgac gccatcgggc gcggccattg atgggtcgcg cacatggtcg gcccaacgcc
     4981 gttgcagggt ggccagcgac tcagccatgg gccacctcgg gccaatgtgc cccggcctgt
     5041 gcctggcgga tctgcgcgac ctcggccagc aactcgggca gtggcgggaa gttgaagtcg
     5101 cgttcgagca gggtggggcg cacgcctacc cgcgcatagg cctcgcgcaa cagcgcccag
     5161 accacgcctt tcaccggcgc accgtgggtg tcgatcttga agccatcgtc ttcatcgaag
     5221 tggcccgcca catgcagcga ggcgacccgc tgggccggca cgcgggccag gaattcgaac
     5281 gcgtcgtagc cgttgttgca ggcattgacg aagacgttgt tgacgtccag cagcaggtcg
     5341 cagtccgcct cggcgagcac ggcattgatg aagtcgatct cgctcatttc cgcgccggca
     5401 acggcgtagt aggaaatgtt ctccacggcg atgcgtcggc ccagcatgtc ctgcacctgg
     5461 gcgatgcgcc cggcgacgtg atgcacggcc tcggcggtga acggcagcgg cagcaggtcg
     5521 tagacgtggc caccggcgac gcagtagctc aggtgttcgc tgtagagctg cacctggtgc
     5581 aggtcgagga aggcacgcgt ctgggccagc agggtgcggt ccagcggatc agggccgccc
     5641 agcgacagcg acaggccgtg gcaggtcagg cggtggcgtt cgctcaacct gcgcagcgct
     5701 gtaccgtgtg caccgccgac gccgatccag ttgtcgggcg agacttcgag gaagtcgatg
     5761 gcaccggccg gcatggccag cagttcgtcg atcaggccac ggcgcaggcc aagaccggcg
     5821 gcattggaag gcaggggcag ggtcatgacg gatgctccag ggagagggcg ccgcctcgga
     5881 ggcggcgccg gttgaacgtc gatcaatcgg cgacgcggga gaacaggccc ttcggcatcg
     5941 gcttgccgtt ggcggtgtag acgctgcgca ggtagtcgtg tgcctcctgc tcgctgatgt
     6001 agccgtcgtg gtcggtgtcg atgcggtcga actcggcggc acgcttggcg gccacggcgt
     6061 tgaactcggc acgcgagacc cggccatcgt ggtcgcggtc ggtgcgggca aacgaggcgt
     6121 cgccgcattt gccttcgcca cactggccct cggccacctt ggccttgccg gcgggcttgc
     6181 cggtggcggt cttgttggct ccgcacttgc cttcaccgca cttgccttcg gcagcagcgc
     6241 tcatggccat ggcactgacc gccagcggct ggatcgccgc ggcctggccg gccagcagca
     6301 ggccaccggc cagggcgatg ccgatggcac cgacgcgcgg caggcgggag gagggggtgg
     6361 tcttggtcga gacggacatg gtggtgactc cttgggaatg cacgcggggc gtgcgggatg
     6421 gacgccgctt gacggcgacg gaaacgaagg gaagaagcgc ggtgaaggga cgaagcggat
     6481 caggcgttgc ggcgacggcg cagtacgtaa cccaccagca gcacaccgcc gagcagggcg
     6541 ccgccgaagc cgatgccggg cagcagcgcg gcaaccggca gcagcagggc gatgaggctg
     6601 acgccccaac ccaagccgtc attgccaacg ggggcgtgct gcgagccggc cagcagacgg
     6661 tcgacgctga gtgcgccacc gccgttgagg atcagtggca gcagcatggc caggaacagc
     6721 agcggcagct tgaagttgcc gtagccctgg tcggtgatcg catagccctg ccagagttcg
     6781 cccaggccgt tccattggtc gggccagtgc acggcggcga tggcgaccac ggtcagtacc
     6841 cagaacacat aagccaccga gcgcgtggcc aggccgagca gcagcatcac tgcacccacc
     6901 agttccagcc aggtggccag ctgccagttc agtgatgcgg gcagggcgga gaacgggaac
     6961 gggaagcgac cttccaggtc ggcgaaccag ttctggccgc ccagcttttc gcggccggat
     7021 tcaaagaact cccaggccag cagggtgcgc agcgccaatg gcgagagcca gcggccgacg
     7081 gcgtccaggc ggggggtata cacggaagag gcggtgctga tcatggtggt gtcctgcggg
     7141 ccagtggtcg atggaggcca tttcaggcgg cgcaggtatc ggcaacgtgt gccgttgccc
     7201 ggggatttgt cagcgactgt ggccgcggcc ggggtttcgt acagtcagat acaaagacga
     7261 tgcgttggtg cacatcgggg cgttgcgcgc ccgcgtgcgg ggagcgatat ccacccgtta
     7321 gcgcccagcc aggaccggcg cccgaatgta tcccactgta gaaacccgcc tgcgccctac
     7381 agtccggtac aactccgcgc cgcagagaaa cagcgccgat acaccggcag gcggaaatgg
     7441 ccgctcccaa caccggagtg ccacccatga tccgtaccac gttgcttgcc gccgctctcg
     7501 cccttgccgg cgccgccgcc ccggccttcg ctgcccaggt cgacgccggc gcgccgccca
     7561 ccatcatcct ggtgcacggc gccttcgccg atggctccag ctggagcaag gtcatcagca
     7621 ccctgcatga ctggaagctg cctgcggtgg ccgtgcagaa tccgctcacc tcgctggccg
     7681 acgatgttgc cgccacccgt cgtgcgattg ccgctgcgcc tggcaaggtg gtgctggtcg
     7741 gccacagctg gggtggcacg gtcatcaccg aagcgggcaa tgacccgaag gtacaggcgc
     7801 tggtgtacgt ggcggccttc gcaccggatg cagggcagtc ttcggcgcaa caaggcgaag
     7861 gttttccggt cggcccgggc ctgacccgcc tgcagcagag ggatggctac ctgaccttgc
     7921 cggccgatgc gattgctcag gacttcgcgc cggacgtgat gaagacgtcg gctgcgctgc
     7981 tgtacagcac ccaggtcccg ctgaaggcca gcgcgctggg cgaggtggtg aacgttgcgg
     8041 cgtggcgcag caagccgagc tggtacgtgc tcagccgtga cgatcgcatg ctgtcgccgc
     8101 agctgcaggc cgccaccgca aagcgcattg gcgcgcagct gcaatcgatc ggcagcagcc
     8161 atgtgtcgct gctttcgcat cctgcgcagg tggccgacag catcctggaa gcggcaggcg
     8221 tgaagcccgc cgaactgccg ttggccgagc aggggggctg agcgatggcc acactgcgag
     8281 ggtatgcact gcccctgctg ctgggcctgc tgggtggagc ggcgttgttg ctggcatggc
     8341 ccggcgccga tgccggcgcg cagccgctcg acgcagcacc gatggcgggg ttcgacggtg
     8401 gcgggccatg gcacaacagc tccccgctca cactgaagca ggtgcggggg caggtggtgc
     8461 tggtcgagtt ctggacctac acctgcagca actgcctcaa cgtggcgccg catgtccacc
     8521 agtggcacgt acggtacgcg tcgcagggcc tgaaggtgat cggcgtgcat acgccggagt
     8581 tcgcctatga agggctgccc ggcaacgtgc gcagggccat cgcacggttg gatatcacct
     8641 ggccggtggt gcaggacaac cagtaccgga tctggaacgc ttggggcaac cgcttctggc
     8701 ccgcgctgta cctgctcgac cggcaggggc gggtggtcta ccgccattac ggcgagggcg
     8761 actacgcgca taccgaaagc cagatccagc gcctgctggc cagcccctga gccgcgctac
     8821 catggccgcg ccgcgcggcg ctgtccccct gccttcatcg agaacgcaat gaaccctgta
     8881 ccgcacatcc ttgtcgtcga cgatgacagt gagatccgcc agatgctggc tgactacctg
     8941 caacgcaacg gcctgcgcgt gagccaggcc gacggtggcc gggccatgcg cgcactgatg
     9001 gatacccatg cagtggacct ggtggtgctg gacgtgatga tgccgggcga ggacggcctg
     9061 agcctgtgcc gcaacctgcg tgccggcaag catcgtgcgg tgccggtggt gctgctgacc
     9121 gcacgcgacg acgagaccga ccgcatcatc ggcctggaaa tgggcgccga cgactacgtg
     9181 accaagccct tttcctcgcg cgaactgctg gcacgcatca acgcggtgat tcgccgcacc
     9241 cggatgctgc cgccgaacct gcaggtgagc gaagccggtc gccagctggc ctttggtgcc
     9301 tggcgcctgg ataccaccgc gcgccatctg ctggatgcgc aggacactgc gtatccgctc
     9361 agtggcgccg aattccgcct gttgcgcgtg ttcctcgatc acgccaatcg ggtgctcagc
     9421 cgcgaccagc tgctcagcct cacccagggc cgcgatgccg aactgttcga ccgctcgatc
     9481 gacctgctgg tcagccgcgt gcgccagcgc ctgggtgacg acgcacgcga gccgacctac
     9541 atcaagaccg tgcgcagcga gggctatgtg ttcagcgtgc cggtgcagtt gctggggccg
     9601 gacgaatgaa caccggcgca cgtcgtccac gctggccgcg cacgctgtcg gcgcggctgc
     9661 tgctggtgct gctgggtgga ctggccctgg cccacgcact gtctttcggc ctgctgttct
     9721 tcgaacgcta ccagtccacc cgcagcatga tgctgcgcaa cctcgacgag gacgtggcgg
     9781 tgagtgtcgc gctgctggag cacctgcccg cagaccagcg cgatgcctgg gtgccgcggc
     9841 tggagcggcg tacctaccgc tacctgctgc gcccggctgt ggccgggccg gggctgcaga
     9901 ccgatcgtgc acgccaggtc accgcgatca tcgacgacag cctgcagcat cgctatccgt
     9961 tgcaggcgcg ccaggtggct cgcctgccgg agcggttcga ggtggaactg cacctgcacg
    10021 acggcacgcc gttgaccatt gaagtcaccc cttcgggcct gccgctggcg cgctggctgc
    10081 ccgccgtgct gctggtgcag ctggcgctgt tgctggtgtg cgcatggctg gcggtgcgcc
    10141 tggccatgcg cccgctgcag cagctgtccc acgcggtgga acagctgcag ccgggcaagg
    10201 acgggccggt actgcctgaa gatggccctg cggaagtagg cggtgcggcg gccgcactca
    10261 acgcgctgca ggcacgcatt cgtggccatg tcagcgagcg cctgcagatc ctcgcagcga
    10321 tctcgcacga tctgcagacc cccatcacgc gcatgaagct tcgggtggag accctgcctg
    10381 aagacagcac ccagcagcga ctgctgtccg acctcgacca cttgggtcaa ctggtgcgtg
    10441 agggcgtggc ctatgcgcgc agcagccacg tcgccagtgg cgcgccggtg tcgatggacc
    10501 tgggcgcgtt cctggccagt gtggtcggcg attacgagga catgggcaag ccggtcagtg
    10561 gcggtgcgcc cgctggactg gtcgtgcaga catggccgca gccgctgcgc cgggtggtcg
    10621 gcaatctggt cgacaacgcg ttgcgctacg ccggtgccgc cgagatcgag gcgggccgcg
    10681 atgaggccgg aagggtgtgg atcggaattt ccgaccgtgg ccccggcatt cccgagggcc
    10741 agctgcaggc agtgctggcg ccgttccatc ggctggaaag ctcgcgcaac cgcgataccg
    10801 gcggcaccgg cctgggcctg gccatcgcgg tgcagctggc gcagtc
//
